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Tamoxifen is the most commonly used hormone therapy for the treatment of breast cancer.

Many women have breast cancer that tests positive for estrogen receptors (ER+). This means that estrogen promotes the growth of the breast cancer cells. Tamoxifen blocks the effects of estrogen on these cells. It is often called an "anti-estrogen."

Tamoxifen slows or stops the growth of cancer cells that are already present in the body. It helps keep the original breast cancer from coming back and helps prevent new cancer in the opposite breast. It also reduces the risk of breast cancer in women who have a high risk for this disease.

In rare cases, tamoxifen is used to treat breast pain (mastalgia), because it reduces estrogen levels that cause breast swelling. This is an unlabeled use.

The drug is technically an estrogen agonist/antagonist, which competitively binds to estrogen receptors in various target tissues. With the tamoxifen molecule bound to this receptor, estrogen is blocked from exerting any action, and an antiestrogenic effect is achieved. Since many forms of breast cancer are responsive to estrogen, the ability of tamoxifen citrate to block its action in such cells has proven to be a very effective treatment.

It is also utilized successfully as a preventative measure, taken by people with an extremely high familial tendency for breast cancer.

Clinical Usagee

Males : an enzyme in the male body (aromatase) is capable of altering testosterone to form estradiol. The structure of estrogen is actually quite similar to testosterone, so its presence in the male body is not all that remarkable. Since this same enzyme can also aromatize endogenous testosterone. the buildup of estrogens can be an important concern.

High levels can cause a number of unwanted side effects, a primary worry being gynecomastia or the development of female breast tissue in men.

Females : Tamoxifen is highly effective in lowering the risk of breast cancer recurrence. In women who have already had breast cancer, tamoxifen also lowers the risk of breast cancer in the opposite breast (contralateral).

For postmenopausal women, a two-stage treatment using tamoxifen and then an aromatase inhibitor, such as anastrozole (Arimidex), exemestane (Aromasin), or letrozole (Femara) may work better than only taking tamoxifen.

Recreational usage

Males : To counter estrogenic side-effects caused by certain androgenic-anabolic Steroids

Dosage

Therapeutic Dosage: Males. 10 mg everyday Female. 20-30 mg everyday with varying stages of Cancer and frequency of menses

Recreational Dosage: Males. 20 mg everyday Female. N/A

Side Effects

Hot flashes, nausea, leg cramps, muscle aches, hair thinning, headache, and numb/tingling skin may occur.

A loss of sexual ability/interest may occur in men. If these effects persist or worsen, notify your doctor promptly. This is not a complete list of possible side effects.

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Preventing and treating symptoms and blockage of airway due to asthma or other lung diseases (eg, emphysema, bronchitis). It may also be used for other conditions as determined by your doctor.

Quibron-T is a xanthine derivative. It works by relaxing the muscle around the airways in the lungs, which allows them to widen and makes breathing easier. It also improves contraction of the diaphragm (the major breathing muscle) and decreases the response of the airways to irritants.

Use Quibron-T as directed by your doctor. Check the label on the medicine for exact dosing instructions. This medicine may be taken on an empty stomach or with food. Try to take this medicine every day at evenly spaced times. If you have questions about the best time to take it, ask your pharmacist.

Some foods may change the effectiveness or increase the side effects of Quibron-T. Talk to your doctor about how you should take Quibron-T with regard to food. Do not suddenly change your diet or eating habits without first checking with your doctor. Take Quibron-T at evenly spaced times throughout the day. Taking Quibron-T at the same time each day will help you remember to take it. Contact your doctor with any questions or concerns about the best way to take Quibron-T. If you miss a dose of Quibron-T, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Quibron-T.

Use Quibron-T as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Store at room temperature away from sunlight and moisture.

Active Ingredient: Theophylline

Do NOT use Quibron-T if:

you are allergic to any ingredient in Quibron-T, similar medicines (eg, aminophylline), or xanthines (eg, caffeine, chocolate)

you are using large amounts of other products that contain xanthine (such as chocolate or caffeinated drinks)

you are taking dipyridamole intravenously (IV), febuxostat, halothane, or St. John's wort

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Quibron-T. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of heart problems (eg, congestive heart failure, cor pulmonale), an irregular heartbeat, liver problems (eg, cirrhosis, hepatitis), viral infection, thyroid problems, increased acid levels in the body, brain or nerve problems, or seizures (eg, epilepsy)

if you are in shock or have a fever, an ulcer, a severe infection, cystic fibrosis, or fluid in the lungs (pulmonary edema)

if you smoke, are stopping or starting smoking, or are exposed to the smoke from cigarettes or marijuana

if you are in the last 3 months of pregnancy

Important safety information:

Drinking alcohol may increase the risk of side effects of Quibron-T. Talk to your doctor before drinking alcohol while you are taking Quibron-T.

Tell your doctor or dentist that you take Quibron-T before you receive any medical or dental care, emergency care, or surgery.

Do not take more than the recommended dose or use more often than prescribed without checking with your doctor. If your symptoms become worse, contact your doctor.

Carry an ID card at all times that says you take Quibron-T.

Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate).

Notify your doctor if you develop a new illness, especially if it is accompanied by fever; if a chronic illness becomes worse; or if you start or stop smoking cigarettes or marijuana.

Tell your doctor if another doctor prescribes a new medicine or tells you to stop using a medicine that you have already been taking. Tell your doctor if you start or stop any medicine, either prescription or over the counter.

Quibron-T will not stop an asthma attack once one has started. Be sure to always carry appropriate rescue medicine (eg, bronchodilator inhaler) with you in case of an asthma attack.

If you have more than one doctor, be sure to tell each of your doctors that you are taking Quibron-T.

Diabetes patients - Quibron-T may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Quibron-T may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Quibron-T.

Lab tests, including blood theophylline levels, may be performed while you use Quibron-T. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Quibron-T with caution in the ELDERLY; they may be more sensitive to its effects.

Caution is advised when using Quibron-T in CHILDREN, especially children younger than 1 year old; they may be more sensitive to its effects. Children may be more likely to experience mild, temporary behavior changes.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor.

You will need to discuss the benefits and risks of using Quibron-T while you are pregnant. Quibron-T is found in breast milk. If you are or will be breast-feeding while you use Quibron-T, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Irritability; mild, temporary caffeine-like effects (eg, headache, nausea, diarrhea, trouble sleeping); mild, temporary changes in behavior; restlessness; temporary increased urination.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dizziness; fast breathing; fast or irregular heartbeat; heart rhythm problems; seizures; severe or persistent nausea, diarrhea, or headache; sleeplessness; tremors; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

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FORMA FARMACEUTICA Y FORMULACION :

Cada capsula contiene:

Amoxicilina trihidratada equivalente a. 250 y 500 mg de amoxicilina

Excipiente, c. b.p. 1 capsula

Hecha la mezcla, cada 5 ml de suspension contienen:

Amoxicilina trihidratada equivalente a. 250 y 500 mg de amoxicilina

Vehiculo, c. b.p. 5 ml

INDICACIONES TERAPEUTICAS : La amoxicilina esta indicada para el tratamiento de infecciones agudas y cronicas de las vias respiratorias superiores e inferiores; para meningitis, infecciones genitourinarias, de la piel y tejidos blandos, gastrointestinales, biliares y en general para el tratamiento de padecimientos causados por bacterias sensibles.

Las bacterias que mas frecuentemente presentan sensibilidad a la amoxicilina son: Haemophilus influenzae. Escherichia coli. Salmonella spp y Typha, Proteus mirabilis. Staphylococcus aureus y epidermidis. Streptococcus faecalis. Neisseria gonorrhoeae. Staphylococcus pneumoniae. Staphylococcus viridans. Peptococcus spp. Peptostreptococcus spp. Helicobacter pylori y estreptococos de los grupos A y B.

FARMACOCINETICA Y FARMACODINAMIA EN HUMANOS : La amoxicilina es una aminopenicilina semisintetica del grupo de los ? - lactamicos. por tanto, es susceptible a la accion de las ? - lactamasas ; posee un amplio espectro contra microorganismos grampositivos.

La amoxicilina desarrolla un efecto bactericida debido a que interfiere con la sintesis de la pared bacteriana, motivando una estructura defectuosa que finalmente se rompe para causar la muerte de la bacteria.

La amoxicilina es estable en un medio acido gastrico y presenta una absorcion oral cercana a 90%; es estable en el medio acido gastrico y la presencia de alimentos no altera su absorcion.

En neonatos su absorcion y eliminacion disminuyen considerablemente.

Se une poco a las proteinas plasmaticas (17 a 20%). Se distribuye ampliamente hacia los liquidos, tejidos y secreciones corporales, como secreciones bronquiales, paranasales. saliva, humor acuoso, liquido cerebroespinal (los niveles de amoxicilina en liquido cefalorraquideo son bajos, excepto cuando las meninges estan inflamadas), liquidos serosos y en el oido medio. Su volumen de distribucion es de 0.2 l/ kg. Atraviesa la barrrera placentaria, se excreta en la leche materna.

Tiene vida media de aproximadamente 60 a 90 minutos; en caso de insuficiencia renal, la eliminacion se reduce, pudiendo alargarse hasta 6 y 18 horas, dependiendo del grado de reduccion de la filtracion glomerular. Su aclaracion plasmatica es de 2.6 mg / min / kg ; su eliminacion tubular puede ser reducida por probenecid. lo que aumenta en 60% sus niveles plasmaticos y se reduce su eliminacion 20%.

Posteriormente, se elimina casi 80% a traves de la via renal sin cambios, activa, durante las seis horas posteriores a su administracion; solo 20 a 30% se metaboliza y forma el acido peniciloico que es inactivo.

CONTRAINDICACIONES : Esta contraindicado su uso en pacientes con hipersensibilidad a las penicilinas o a las cefalosporinas y en infecciones causadas por bacterias productoras de ? - lactamasas.

PRECAUCIONES GENERALES : Cuando se utilice la amoxicilina por periodos prolongados se debera considerar la posibilidad de que aparezcan infecciones agregadas por agentes micoticos o bacterianos como: Candida , Pseudomonas o Enterobacter . Cuando exista sospecha de infecciones agregadas, se debera suspender de inmediato la amoxicilina y se tendra que valorar la posibilidad de realizar un tratamiento adecuado.

Al igual que con otras penicilinas, se tendra que tomar en cuenta el riesgo de reacciones de hipersensibilidad que pueden ir de leves a graves, como la anafilaxia.

Aunque generalmente estas reacciones ocurren en pacientes con antecedentes de hipersensibilidad a las penicilinas, alergenos o cefalosporinas. podrian aparecer tambien en ausencia de exposicion previa conocida. Si llegaran a ocurrir reacciones de hipersensibilidad, la amoxicilina se suspendera de inmediato y se debera instaurar una terapia apropiada.

Las reacciones anafilacticas severas requieren manejo inmediato, con oxigeno, epinefrina, esteroides intravenosos, vias aereas permeables e inclusive entubacion endotraqueal.

PRECAUCIONES O RESTRICCIONES DE USO DURANTE EL EMBARAZO O LA LACTANCIA : Los estudios realizados con amoxicilina no han demostrado accion teratogenica ; no obstante, la seguridad de su uso durante el embarazo aun no ha sido establecida.

La amoxicilina es excretada por la leche materna por lo que su uso durante el periodo de lactancia queda restringido a casos donde los beneficios superen los riesgos, dado que el infante puede desarrollar una hipersensibilidad a la amoxicilina.

REACCIONES SECUNDARIAS Y ADVERSAS :

Pueden presentarse con el uso de la amoxicilina.

Gastrointestinales: Nauseas, vomito, diarrea y, en raras ocasiones colitis seudomembranosa. Ademas, puede presentarse una elevacion serica de la TGO y TGP, si bien no se ha establecido su repercusion clinica.

Reacciones de hipersensibilidad: Eritema maculopapular. eritema multiforme, sindrome de Stevens - Johnson. urticaria y casos severos de anafilaxia.

Sistema hemolinfatico : Anemia, trombocitopenia. purpura trombocitopenica. eosinofilia. leucopenia y agranulocitopenia.

Sistema nervioso central: Hiperactividad, agitacion, ansiedad, insomnio, confusion y cambios en la conducta.

INTERACCIONES MEDICAMENTOSAS Y DE OTRO GENERO : La administracion conjunta con probenecid puede aumentar el tiempo de excrecion de la amoxicilina. La administracion de alopurinol y amoxicilina puede desencadenar reacciones cutaneas.

La cimetidina puede aumentar la absorcion de la amoxicilina. Debe evitarse el consumo de alcohol, ya que se puede presentar una reaccion toxica llamada disulfiramica.

ALTERACIONES DE PRUEBAS DE LABORATORIO : Los resultados obtenidos en pruebas de laboratorio mediante metodos colorimetricos se pueden ver afectados, tal es el caso de glucemia, glucosuria, ya que pueden presentarse falsos positivos en las determinaciones de glucosa en orina al utilizar sulfato de cobre como reactivo. Ademas, altera pruebas colorimetricas de proteinas y produce falsos positivos en la prueba de Cooms. Y eleva de manera moderada las TGO y TGP.

PRECAUCIONES Y RELACION CON EFECTOS DE CARCINOGENESIS MUTAGENESIS TERATOGENESIS Y SOBRE LA FERTILIDAD : Los estudios desarrollados con amoxicilina no han demostrado efectos de carcinogenesis. mutagenesis. teratogenesis ni alteraciones sobre la fertilidad.

DOSIS Y VIA DE ADMINISTRACION :

Adultos: De 500 mg a 1 g cada 8 horas por via oral. La dosis puede calcularse a razon de 50 a 100 mg / kg de peso/dia.

Ninos: De 250 a 500 mg cada 8 horas por via oral.

El calculo con base en el peso corporal debera hacerse de 20 a 40 mg / kg /dia.

El tratamiento debera continuar por lo menos hasta despues de 72 horas de haber desaparecido los sintomas y la negativizacion de los cultivos.

SOBREDOSIFICACION O INGESTA ACCIDENTAL: MANIFESTACIONES Y MANEJO (ANTIDOTOS) : La amoxicilina. aunque resulta bien tolerada y no presenta efectos toxicos, en los casos de sobredosis puede presentarse diarrea, lo cual generalmente desaparece al retirar la administracion. En su caso, se deberan tratar los sintomas, ya sean leves como mareo, nauseas y vomito, que incluso pueden requerir la administracion oral de carbon activado y en caso de ingesta accidental por personas alergicas a este medicamento, el tratamiento incluye la administracion de antihistaminicos, corticosteroides y terapia de apoyo; si se presentara choque anafilactico, se debera administrar adrenalina 1:1, 000 (0.5 ml y 0.5 ml S. C .) a juicio del medico.

Caja con 10 capsulas de 250 mg.

Caja con 12 o 15 capsulas de 500 mg.

Caja con frasco con polvo para reconstituir a 75 ml (250 mg /5 ml )

Caja con frasco con polvo para reconstituir a 75 ml (500 mg /5 ml ).

RECOMENDACIONES PARA ALMACENAMIENTO : La suspension debera conservarse a temperatura ambiente a no mas de 30 ?C en un lugar seco. Hecha la mezcla, el producto se conserva durante 7 dias a temperatura ambiente a no mas de 30 ?C o 14 dias en refrigeracion entre 2 a 8 ?C. Las tabletas bastara que se conserven en lugar fresco (entre 8 y 15 °C ) y seco.

LEYENDAS DE PROTECCION : Su venta requiere receta medica. No se deje al alcance de los ninos. Literatura exclusiva para medicos.

NOMBRE DEL LABORATORIO Y DIRECCION : Hecho en Mexico por: ANTIBIOTICOS DE MEXICO, S. A. de C. V. Las Flores No. 56 Colonia La Candelaria 04380 Mexico, D. F . * Marca registrada

NUMERO DE REGISTRO DEL MEDICAMENTO : Regs. Nums. 362M2000 y 233M2002, S. S.A. IV IEAR-206929/R2000 y GEAR-04361203270/RM2004/IPPA

Publicado en: Farmacos

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The LINX System is a small flexible band of interlinked titanium beads with magnetic cores. The magnetic attraction between the beads helps the LES resist opening to gastric pressures, preventing reflux from the stomach into the esophagus. (See Fig. 1) Swallowing forces temporarily break the magnetic bond, allowing food and liquid to pass normally into the stomach. (See Fig. 2) Magnetic attraction closes the LES immediately after swallowing, restoring the body's natural barrier to reflux. (See Fig. 3).

Figure 1: The LINX System is designed to help the LES resist opening to gastric pressures.

Figure 1: The LINX System helps the LES resist opening to gastric pressures.

Figure 2: The LINX System is designed to expand to allow for normal swallowing.

Figure 2: The LINX System expands to allow for normal swallowing.

Figure 3: Magnetic attraction of the device is designed to close the LES immediately after swallowing.

Figure 3: Magnetic attraction closes the LES immediately after swallowing.

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Figure 1: A precision sizing tool is used to determine the appropriate size LINX System.

Figure 2: The LINX System is positioned around the LES using suture tails.

Figure 3: The ends of the LINX System are aligned and joined for secure closure.

Patients are placed under general anesthesia during the procedure. The LINX System does not require any anatomic alteration of the stomach. Most patients go home the day after surgery and resume a normal diet.

Patients are placed under general anesthesia during the procedure, which generally lasts less than an hour. Unlike other surgical treatments for GERD, the LINX System does not require any anatomic alteration of the stomach. Most patients go home the day after surgery and resume a normal diet.

Torax ® Medical, LINX ® Reflux Management System and FENIX ® Continence Restoration System are registered trademarks of Torax Medical, Inc. © 2016 Torax® Medical, Inc. All rights reserved.

Board of Directors

Timothy Mills, Ph. D. Managing Director

Sanderling Ventures

Dr. Mills has over twenty-five years of experience in biomedical research, corporate management and venture investing. Dr. Mills joined Sanderling as an Operating Partner in July 1998, and was promoted to Managing Director in 2000. At Sanderling, Dr. Mills has focused on early stage investments in Medical Devices, Biotherapeutics, and i-Health. He has served Sanderling's portfolio companies as Chairman, Chief Executive Officer, Director, and/or management team member. Portfolio companies served include Stereotaxis (NASDAQ: STXS) and Stentor, acquired by Royal Philips Electronics (NYSE: PHG, AEX: PHI). Currently, his services include Chairman of Torax Medical, Taligen Therapeutics, Pulsar Vascular, Theregen and Director for CardioNet, Novostent, InfraReDx, TriageWireless and others.

Prior to joining Sanderling, Dr. Mills served as the Corporate Vice President of New Business Development and Chief Scientific Officer of Target Therapeutics, a medical device company that was acquired by Boston Scientific (NYSE: BSX) in 1997. From July 1994 to July 1997, he was a director for Prograft Medical, a Target affiliate that was acquired by W. L Gore & Associates.

Prior to joining Target in 1994, Dr. Mills served as Director of Business Development and Advanced Research & Development in the Interventional Cardiology Division of Baxter Healthcare, now Edwards Life Science (NYSE: EW). Dr. Mills' previous academic appointments included service as the Director of the Artificial Heart Program at the University of California, Irvine Medical Center and membership in the University of California, San Francisco Radiology Department.

Dr. Mills received his Ph. D. in Bioengineering from the University of California, Berkeley & San Francisco School of Medicine, his M. S. in Electrical Engineering & Computer Science from the University of California, Berkeley, and his B. S. in Electrical Engineering from the University of Colorado, Boulder.

James E. Thomas, Partner

Thomas, McNerney & Partners

Mr. Thomas is a co-founder of Thomas, McNerney & Partners and has been investing in health care companies since 1992. Mr. Thomas previously headed Warburg Pincus LLC's medical technology private equity practice, where he had responsibility for investments in biotechnology, pharmaceutical, medical device and diagnostic companies. Prior to joining Warburg, Mr. Thomas was a Vice President at Goldman Sachs International in London. He is currently a board member of CAS Medical Systems, Inc. (CASM), Clarus Therapeutics, Inc. Galil Medical Ltd. Keystone Dental, Inc. and Torax Medical, Inc. Historical investments include: American Medical Systems Holdings, Inc. (AMMD), Coley Pharmaceutical Group, Inc. (COLY sold to Pfizer), The Medicines Company (MDCO), NeXagen, Inc. (NXGN/NXTR sold to Gilead Sciences, Inc.),OsteoBiologics, Inc. (sold to Smith & Nephew plc), Oxford GlycoSciences, plc (OGSI sold to Celltech Group plc), Transkaryotic Therapies, Inc. (TKTX sold to Shire Pharmaceuticals Group plc), Visible Genetics, Inc. (VGIN sold to Bayer Corporation), Wright Medical Group, Inc. (WMGI), and Xomed Surgical Products, Inc. (XOMD sold to Medtronic, Inc.). Mr. Thomas graduated magna cum laude with a B. S. in Economics from the Wharton School at the University of Pennsylvania and received an M. Sc. in Economics from the London School of Economics.

Charles E. Larsen, Managing Director

Accuitive Medical Ventures

As a co-founder of Accuitive Medical Ventures, Charlie brings over 35 years of operating experience, as well as expansive technical understanding and experience in the medical device industry. Charlie was a co-founder of Novoste Corporation with Tom Weldon where his efforts as a director and executive were critical to its ultimate success. Charlie co-founded The Innovation Factory and serves as its Vice Chairman. Through his role at The Innovation Factory, he is co-founder of AcuFocus, LipoSonix, Cerebral Vascular Applications (CVA), NeoVista, Neuronetics, Cellutions, OsteoLign, AqueSys and Halscion. He holds over 20 issued U. S. patents on medical devices.

Before joining Novoste, Charlie held positions with Novoste Puerto Rico, Cordis Corporation, Key Pharmaceuticals and Parke-Davis/Warner Lambert in executive, senior engineering and project management roles. Charlie received a B. S. in Mechanical Engineering from the New Jersey Institute of Technology.

Charlie currently serves on the boards of Inogen and CardioFocus.

Chris Grant, Senior Vice-President and Managing Director

Kaiser Permanente Ventures

Mr. Grant is Senior Vice President and Managing Director of Kaiser Permanente's venture capital and corporate development group. He oversees Kaiser Permanente's venture investment strategy which is designed to support the company's healthcare mission while generating venture capital rates of return. Additionally, he oversees corporate development and merger and acquisitions company-wide. Mr. Grant is a Director or has observation rights to the board of numerous portfolio companies. Prior to the formation of the venture fund in 2000, Mr. Grant was responsible for creating, developing and managing a portfolio of new products and business lines for the organization. Before joining Kaiser Permanente in 1995, Mr. Grant held several positions on the Business Development and Financial Management Team of Rockwell International Corp. Additionally, Mr. Grant serves on the Board of Trustees of the Public School District and two charitable funds.

Mr. Grant has a Bachelor's degree in Business from the University of California, Santa Barbara and has completed executive management programs at Kenaan Flagler School of Business (UNC at Chapel Hill) as well as Venture Capital Institute Graduate and Undergraduate programs.

Todd Berg, Co–Founder, President and CEO

Torax Medical

Mr. Berg brings over fifteen years of experience with pioneering technologies and a proven track record in funding and marketing early stage start-ups to the Venture Capital and clinical community.

Prior to Torax Medical, Mr. Berg was with St. Jude Medical where he was the Vice President of Emerging Technology.

Prior positions at St. Jude Medical included General Manager of the Anastomotic Technology Group and Vice President of Research and Development for the Cardiac Surgery Division. He joined St. Jude Medical through the acquisition of Vascular Science in 1999 where he was the Vice President of Research and Development. Prior to Vascular Science he was with SciMed Life Systems and Boston Scientific.

Mr. Berg holds over sixty patents in the area of medical technology and has published numerous articles in professional journals. He has a Bachelor of Science degree in Mechanical Engineering from the University of Minnesota.

Torax ® Medical, LINX ® Reflux Management System and FENIX ® Continence Restoration System are registered trademarks of Torax Medical, Inc. © 2016 Torax® Medical, Inc. All rights reserved.



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Remind Synonyms, Remind Antonyms, Remid

remind

Example Sentences for remind

Shall I complain, or only remind you how all right and wrong is confused?

I wish I could have foreseen then how soon I might remind you of this.

I know that several of my readers may remind me of Sir Boyle Roche, whose bulls have become not only notorious, but proverbial.

You reproved me for my fear and mistrust then; and I must beg leave to remind you of what you then said.

But I venture to remind you, also, of some other words I used at that time, and which I ask permission to read to you.

In Sweden there is a story that may remind us of the Sutherlandshire legend.

My stomach was beginning to remind me that I had given it nothing for twelve hours or so, while I had worked my legs hard.

I must remind you again, Bradish, that you were talking to me in pretty lively style.

And that leads me to say that men often remind me of pears in their way of coming to maturity.

I should remind you that we have well over two thousand inmates here.

remind

Example Sentences for remind

Shall I complain, or only remind you how all right and wrong is confused?

I wish I could have foreseen then how soon I might remind you of this.

I know that several of my readers may remind me of Sir Boyle Roche, whose bulls have become not only notorious, but proverbial.

You reproved me for my fear and mistrust then; and I must beg leave to remind you of what you then said.

But I venture to remind you, also, of some other words I used at that time, and which I ask permission to read to you.

In Sweden there is a story that may remind us of the Sutherlandshire legend.

My stomach was beginning to remind me that I had given it nothing for twelve hours or so, while I had worked my legs hard.

I must remind you again, Bradish, that you were talking to me in pretty lively style.

And that leads me to say that men often remind me of pears in their way of coming to maturity.

I should remind you that we have well over two thousand inmates here.



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A Patient S Guide To Taking Warfarin, Fargem

A Patient's Guide to Taking Warfarin

Warfarin (brand names Coumadin and Jantoven) is a prescription medication used to prevent harmful blood clots from forming or growing larger. Beneficial blood clots prevent or stop bleeding, but harmful blood clots can cause a heart attack. stroke. deep vein thrombosis or pulmonary embolism. Because warfarin interferes with the formation of blood clots, it is called an anticoagulant. Many people refer to anticoagulants as “blood thinners”; however, warfarin does not thin the blood but instead causes the blood to take longer to form a clot.

How Does Warfarin Work? The formation of a clot in the body is a complex process that involves multiple substances called clotting factors. Warfarin decreases the body’s ability to form blood clots by blocking the formation of vitamin K–dependent clotting factors. Vitamin K is needed to make clotting factors and prevent bleeding. Therefore, by giving a medication that blocks the clotting factors, your body can stop harmful clots from forming and prevent clots from getting larger.

Monitoring and Dosing Tips The goal of warfarin therapy is to decrease the clotting tendency of blood, not to prevent clotting completely. Therefore, the effect of warfarin must be monitored carefully with blood testing. On the basis of the results of the blood test, your daily dose of warfarin will be adjusted to keep your clotting time within a target range. The blood test used to measure the time it takes for blood to clot is referred to as a prothrombin time test, or protime (PT). The PT is reported as the International Normalized Ratio (INR).

The INR is a standardized way of expressing the PT value. The INR ensures that PT results obtained by different laboratories can be compared. It is important to monitor the INR (at least once a month and sometimes as often as twice weekly) to make sure that the level of warfarin remains in the effective range. If the INR is too low, blood clots will not be prevented, but if the INR is too high, there is an increased risk of bleeding. This is why those who take warfarin must have their blood tested so frequently.

Unlike most medications that are administered as a fixed dose, warfarin dosing is adjusted according to the INR blood test results; therefore, the dose usually changes over time. Coumadin/ warfarin pills come in different colors, and each color corresponds to a different dose (Figure).

Difference Between Brand-Name and Generic Medications Generic drugs are supposed to have the same dosage, therapeutic effects, route of administration, side effects, and strength as the original drug. The U. S. Food and Drug Administration requires that all generic drugs be as safe and effective as brand-name drugs.

Generic drugs are often less expensive than their brand-name counterparts, because the generic manufacturers have not incurred the expenses of developing and marketing a new drug. In the United States, trademark laws do not allow generic drugs to look exactly like the brand-name drug; however, the generic drug must have the same active ingredients. In the case of Coumadin (a brand-name product) and warfarin (a generic product), the manufacturers attempted to keep the colors consistent with the strength of the pills. The goal is to allow the patient to identify the color-coded dose and prevent mix-ups or errors. Therefore, if the color or dose of the dispensed tablet appears different from the pill taken previously, the patient should immediately notify the dispensing pharmacist or healthcare provider.

In 2006, the Food and Drug Administration issued a public health advisory to healthcare professionals and consumers that U. S. prescriptions filled abroad may give patients the wrong active ingredient for treating their health condition. Some FDA–approved products have the same brand names as drug products marketed outside the United States but contain completely different active ingredients. Therefore, patients who fill U. S. prescriptions abroad, either when traveling or online, need to maintain caution and vigilance. We advise U. S. residents against purchasing drugs at foreign Internet pharmacies. Foreign drugs may use identical or potentially confusing brand names for products with active ingredients that differ from U. S. drugs. Warfarin has many foreign brand names (Table 1). Patients who do fill prescriptions abroad should ensure the accuracy and quality of the medication dispensed.

Warfarin must be taken exactly as prescribed . Never increase or decrease your dose unless instructed to do so by your healthcare provider. If a dose is missed or forgotten, call your healthcare provider for advice.

Table 1. Foreign Brand Names for Warfarin

Foreign Brand Name for Warfarin

Side Effects The major complications associated with warfarin are clotting due to underdosing or bleeding due to excessive anticoagulation. The most serious bleeding is gastrointestinal or intracerebral. Excessive bleeding can occur in any area of the body, and patients taking warfarin should report any falls or accidents, as well as signs or symptoms of bleeding or unusual bruising, to their healthcare provider.

Signs of unusual bleeding include:

bleeding from the gums,

blood in the urine,

bloody or dark stool,

a nosebleed, or

vomiting blood.

An unusual headache or a headache that is more severe than usual may signal intracerebral bleeding.

When to Call Your Healthcare Provider If you experience the following signs of bleeding, you should call 9-1-1 or your healthcare provider immediately:

Severe headache, confusion, weakness or numbness

Coughing up large amounts of bright red blood

Vomiting blood

Bleeding that will not stop

Bright red blood in stool

Fall or injury to the head

Headache that is severe or unusual

Some simple changes to decrease the risk of bleeding while taking warfarin include the following:

Use a soft-bristle toothbrush

Floss with waxed floss rather than unwaxed floss

Shave with an electric razor rather than a blade

Take care when using sharp objects, such as knives and scissors

Avoid activities that have a risk of falling or injury (e. g. contact sports)

Warfarin and Lifestyle Changes in daily living can affect the INR. It is important to know common do’s and don’ts for warfarin therapy.

Pregnancy Warfarin is not recommended during pregnancy. A woman who becomes pregnant or plans to become pregnant while undergoing warfarin therapy should notify her healthcare provider immediately.

Surgery/Dental and Other Medical Procedures It is important to tell all your healthcare providers that you are taking warfarin. If you are having surgery, dental work, or other medical procedures, you may need to stop taking warfarin.

Travel Check with your healthcare provider if you expect to travel. While traveling, it is important to carry your medication with you at all times. Do not put medication into checked baggage.

Common Do’s and Don’ts

Do watch for signs and symptoms of bleeding.

Never double a dose because you missed a dose.

Do tell your healthcare provider when you get sick or hurt.

Don’t start new medications, herbals, or supplements without talking to your healthcare provider.

Do take warfarin exactly as prescribed.

Don’t make changes to your warfarin dose without talking to your healthcare provider.

Do tell anyone giving you medical or dental care that you are taking warfarin.

Do keep appointments for blood tests.

Warfarin Interacts With Other Medications Patients who take warfarin should consult with their healthcare provider before taking any new medication, including over-the-counter (nonprescription) drugs, herbal medicines, vitamins or any other products. Many medications can alter the effectiveness of warfarin, resulting in an INR that is either too high or too low. Some of the most common over-the-counter aspirin, such as: ibuprofen (brand name Advil) and naproxen (brand name Aleve), enhance the anticoagulant effects of warfarin and increase the likelihood of harmful bleeding. Warfarin Interacts With Alcohol and With Certain Foods

Alcohol - Alcohol intake can affect how the body metabolizes warfarin. Patients undergoing warfarin therapy should avoid drinking alcohol on a daily basis. Alcohol should be limited to no more than 1 to 2 servings of alcohol occasionally. The antiplatelet effect of alcohol increases the risk of major bleeding, even if the INR remains within the target range.

Foods - Some foods can interfere with the effectiveness of warfarin. The most important point to remember is to eat what you normally eat and not to make any major changes in your diet without contacting your healthcare provider.

Vitamin K - Eating an increased amount of foods rich in vitamin K can lower the PT and INR, making warfarin less effective and potentially increasing the risk of blood clots. Patients who take warfarin should aim to eat a relatively similar amount of vitamin K each week. The highest amount of vitamin K is found in green and leafy vegetables such as broccoli, lettuce, and spinach. It is not necessary to avoid these foods; however, it is important to try to keep the amount of vitamin K you eat consistent. Download our quick reference guide to foods that are high and low in Vitamin K.

Wear Medical Identification Those who require long-term warfarin should wear a medical alert bracelet, necklace, or similar alert tag at all times. If an accident occurs and the person is too ill to communicate, a medical alert tag will help responders provide appropriate care. The alert should include a list of major medical conditions and the reason warfarin is needed, as well as the name and phone number of an emergency contact.

Where to Get More Information Your healthcare provider is the best source of information for questions and concerns related to your medical problem. Because no 2 patients are exactly alike, and recommendations can vary from 1 person to another, it is important to seek guidance from a provider who is familiar with your individual condition.

This content was last reviewed on 10/23/2014.

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Em Kit - Digital Dowsing, Emkit

EM Kit

Product Description

EM Kit Overview

Get started now with investigating Electromagnetic Fields (EMF) and Electromagnetic (EM) Activity! The EM Kit Includes:

The Rechargeable EM Pump creates an EMF Siren by oscillating the field. Just like an audio siren is easy for the human ears to detect, the EM Pump will act as a beacon within the Electromagnetic Fields.

The Rechargeable EM White Noise functions as an amplifier for magnetic fields within the range of human speech. Based on wave propagation, the EM white noise sweeps at 300 – 1.1khz.

The EVP Mic allows you to record any Electromagnetic activity that occur and translate it into Audio Waves. This inductive mic will not pick up your voice! Only Electromagnetic Energy!

Carrying Case with custom cut foam and engraved kit name.

USB to USB Mini charging cable

Experiment and investigate EMF today!

The EM Kit Carrying Case

Charging your EM-PUMP and White Noise EM

Charge the EM Pump and White Noise EM with the provided USB to USB Mini cable. The USB Mini side of the cable will plug into the bottom of the unit. Plug the standard sized end of the USB cable into any USB port on a computer or spare cell phone charger. Charging may vary from 30 minutes to 2.5 hours. During operation the light next to the ON/OFF switch will not be illuminated, only while charging. Run time on a fully charged unit ranges from 6-7 hours. For best results we recommend charging prior to each investigation. Please note that the cable provided with the unit is a USB to USB Mini and many cell phone charging cables will not work as most phones come with a USB Micro . Depicted is a the slightly larger USB Mini end on the left versus the smaller USB Micro on the right.

Investigation Sheet for EM Kit

Gradient Directions:

Orient the Gradient to the cardinal directions and fill out the sheet.

Set your equipment on the circles.



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Mevinolin Advanced Patient Information, Mevinolin

HMG-COA REDUCTASE INHIBITORS (Systemic)

Category

Antihyperlipidemic —Atorvastatin; Cerivastatin# ; Fluvastatin; Lovastatin; Pravastatin; Simvastatin

HMG-CoA reductase inhibitor —Atorvastatin; Cerivastatin# ; Fluvastatin; Lovastatin; Pravastatin; Simvastatin

Description

Atorvastatin, cerivastatin#. fluvastatin, lovastatin, pravastatin, and simvastatin are used to lower levels of cholesterol and other fats in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels.

These medicines belong to the group of medicines called 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. They work by blocking an enzyme that is needed by the body to make cholesterol. Thus, less cholesterol is made.

HMG-CoA reductase inhibitors are available only with your doctor's prescription, in the following dosage forms:

# Removed from the market by Bayer in August 2001.

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For HMG-CoA reductase inhibitors, the following should be considered:

Allergies— Tell your doctor if you have ever had any unusual or allergic reaction to HMG-CoA reductase inhibitors. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Diet— Before prescribing medicines to lower your cholesterol, your doctor will probably try to control your condition by prescribing a personal diet for you. Such a diet will be lower in total fat, particularly saturated fat, and dietary cholesterol. Many people are able to control their condition by carefully following their doctor's orders for proper diet and exercise. Medicine is prescribed only when additional help is needed and is effective only when a schedule of diet and exercise is properly followed.

Also, this medicine is less effective if you are greatly overweight. It may be very important for you to go on a reducing diet. However, check with your doctor before going on any diet.

Pregnancy— HMG-CoA reductase inhibitors should not be used during pregnancy or by women who plan to become pregnant in the near future. These medicines block formation of cholesterol, which is necessary for the fetus to develop properly. HMG-CoA reductase inhibitors may cause birth defects or other problems in the baby if taken during pregnancy. An effective form of birth control should be used during treatment with these medicines. Check with your doctor immediately if you think you have become pregnant while taking this medicine . Be sure you have discussed this with your doctor.

Breast-feeding— These medicines are not recommended for use during breast-feeding because they may cause unwanted effects in nursing babies.

Children— Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of HMG-CoA reductase inhibitors in children with use in other age groups. However, atorvastatin, lovastatin, and simvastatin have been used in a limited number of children under 18 years of age. Early information seems to show that these medicines may be effective in children, but their long-term safety has not been studied.

Older adults— This medicine has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines— Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking HMG-CoA reductase inhibitors, it is especially important that your health care professional know if you are taking any of the following:

Cyclosporine (e. g. Sandimmune) or

Gemfibrozil (e. g. Lopid) or

Clofibrate (e. g. Atromid-S) or

Fenofibrate (e. g. Tricor) or

Niacin—Use of these medicines with an HMG-CoA reductase inhibitor may increase the risk of developing muscle problems and kidney failure

Digoxin (e. g. Lanoxin)—Use with atorvastatin, fluvastatin, or simvastatin may increase blood levels of digoxin, increasing the risk of side effects

Oral contraceptives, (birth control tablets)—Atorvastatin may increase the blood levels of the birth control hormones, increasing the risk of side effects

HIV protease inhibitors (Amprenavir [e. g. Agenerase], Indinavir [e. g. Crixivan], Nelfinavir [e. g. Viracept], Ritonavir [e. g. Norvir], Saquinavir [e. g. Fortovase, Invirase]) or

Nefazodone (e. g. Serzone)—Use with simvastatin may increase the risk of developing muscle problems and kidney failure

Verapamil (e. g. Calan, Isoptin)—Use with simvastatin may increase the risk of muscle problems

Other medical problems— The presence of other medical problems may affect the use of HMG-CoA reductase inhibitors. Make sure you tell your doctor if you have any other medical problems, especially:

Alcohol abuse (or history of) or

Liver disease—Use of this medicine may make liver problems worse

Convulsions (seizures), not well-controlled, or

Organ transplant with therapy to prevent transplant rejection or

If you have recently had major surgery—Patients with these conditions may be at risk of developing problems that may lead to kidney failure

Proper Use of This Medicine

Use this medicine only as directed by your doctor . Do not use more or less of it, and do not use it more often or for a longer time than your doctor ordered.

Remember that this medicine will not cure your condition but it does help control it. Therefore, you must continue to take it as directed if you expect to keep your cholesterol levels down.

Follow carefully the special diet your doctor gave you . This is the most important part of controlling your condition, and is necessary if the medicine is to work properly.

For patients taking atorvastatin and simvastatin :

Do not take these medicines with large amounts of grapefruit juice

For patients taking lovastatin :

For extended-release tablets: This medicine works better when it is taken at bedtime. The extended-release tablets should be swallowed whole. They should not be chewed, crushed, or cut.

For tablets: This medicine works better when it is taken with food. If you are taking this medicine once a day, take it with the evening meal. If you are taking more than one dose a day, take each dose with a meal or snack.

Dosing— The dose of these medicines will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The number of capsules or tablets that you take depends on the strength of the medicine.

For atorvastatin

For oral dosage form (tablets):

For high cholesterol:

Adults—10 to 80 milligrams (mg) once a day.

Children 10 to 17 years of age—10 to 20 milligrams (mg) once a day.

Childrenyounger than 10 years of age—Use and dose must be determined by your doctor.

For cerivastatin

For oral dosage form.

Removed from the market by Bayer in August 2001

For fluvastatin

For oral dosage form (capsules):

For high cholesterol:

Adults—20 to 40 milligrams (mg) once a day in the evening.

Children—Use and dose must be determined by your doctor.

For lovastatin

For oral dosage form (extended-release tablets):

For high cholesterol:

Adults—10 to 60 milligrams (mg) once a day at bedtime.

Children—Use and dose must be determined by your doctor.

For oral dosage form (tablets):

For high cholesterol:

Adults— 20 to 80 milligrams (mg) a day taken as a single dose or divided into smaller doses. Take with evening meals.

Children—Use and dose must be determined by your doctor.

For pravastatin

For oral dosage form (tablets):

For high cholesterol:

Adults—10 to 40 mg once a day at bedtime.

Children—Use and dose must be determined by your doctor.

For simvastatin

For oral dosage form (tablets):

For high cholesterol:

Adults—5 to 80 mg a day.

Children—Use and dose must be determined by your doctor.

Missed dose— If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage— To store this medicine:

Keep out of the reach of children.

Store away from heat and direct light.

Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.

Keep the medicine from freezing. Do not refrigerate.

Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

It is very important that your doctor check your progress at regular visits . This will allow your doctor to see if the medicine is working properly to lower your cholesterol levels and that it does not cause unwanted effects.

Check with your doctor immediately if you think that you may be pregnant . HMG-CoA reductase inhibitors may cause birth defects or other problems in the baby if taken during pregnancy. Your doctor may recommend an appropriate method of birth control to prevent adolescent girls and women of child bearing potential from getting pregnant.

Do not stop taking this medicine without first checking with your doctor . When you stop taking this medicine, your blood cholesterol levels may increase again. Your doctor may want you to follow a special diet to help prevent this from happening.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine .

Check with your doctor immediately if you have unexplained muscle pain, tenderness, or weakness .

Side Effects of This Medicine

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

Fever; muscle aches or cramps; severe stomach pain; unusual tiredness or weakness

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; skin rash; stomach pain



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Alfuzosin - Side Effects, Dosage, Interactions, Alfuzosinum

Alfuzosin

Alfuzosin is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blocker. Alfuzosin helps relax the muscles in the prostate and bladder neck, making it easier to urinate.

Alfuzosin is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate).

Alfuzosin may also be used for purposes not listed in this medication guide.

You should not take alfuzosin if you have moderate to severe liver disease.

There are many other drugs that can interact with alfuzosin. Tell your doctor about all medications you use.

You should not take alfuzosin if you are allergic to it, or if you have:

moderate to severe liver disease.

Some medicines can interact with alfuzosin and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs:

imatinib;

isoniazid;

nefazodone;

an antibiotic--clarithromycin, telithromycin;

antifungal medicine--itraconazole, ketoconazole, posaconazole, voriconazole;

heart medication--nicardipine, quinidine;

antiviral medicine to treat hepatitis C or HIV/AIDS--atazanavir, boceprevir, cobicistat, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, telaprevir; or

medicines similar to alfuzosin--doxazosin, prazosin, silodosin, tamsulosin, or terazosin.

To make sure alfuzosin is safe for you, tell your doctor if you have:

low blood pressure, or a history of low blood pressure caused by taking medications;

kidney disease;

a personal or family history of long QT syndrome;

heart disease, angina (chest pain), high blood pressure;

coronary artery disease (hardened arteries);

a history of prostate cancer; or

a condition for which you take a nitrate medication (such as nitroglycerin).

Alfuzosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medicine.

Although alfuzosin is not for use in women, this medicine is not expected to harm an unborn baby or a nursing baby. If you are a woman and you take alfuzosin, tell your doctor if you are pregnant or breast-feeding.

Alfuzosin is not approved for use by anyone younger than 18 years old.

Alfuzosin Side Effects

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol with this medicine can cause side effects.

Many drugs can interact with alfuzosin, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with alfuzosin. Give a list of all your medicines to any healthcare provider who treats you.

Alfuzosin Dosage

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Alfuzosin is usually taken once daily just after a meal. Do not take alfuzosin on an empty stomach. Take the medicine at the same time each day.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Alfuzosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it. You may feel very dizzy when you first wake up. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

While using alfuzosin, your blood pressure and prostate will need to be checked often.

Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, or heavy sweating. Call your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Store at room temperature away from moisture, heat, and light.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Copyright 1996-2016 Cerner Multum, Inc.

Latest Update: 5/16/2016, Version: 8.02



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Altizem

Recognized by the pharmaceutical industry for the quality of our services, we seek for the development of our company. a Data Manager

You have a scientific background (BAC +5, MASTER/DESS/DEA) and you have one to two years experience in a pharmaceutical company or in a CRO ideally on Data Management tool (CT4, Oracle Clinical. ). The practice of Pl/Sql language would be an advantage.

You speak English well, you have good communication skills, you are organized, rigorous and you would like to join a company in expansion which will be able to answer your needs of career advancement.

altizem is a dynamic and innovative CRO, close to its professionals.

Recognized by the pharmaceutical industry for the quality of our services, we seek for the development of our company. a Biostatistician

You have a higher degree in Statistics (ENSAI, ISUP, DEA, DESS, MASTER) and you have one to two years experience in a pharmaceutical company or in a CRO. A good knowledge of SAS (bases, macro and stat) is necessary.

You speak English well, you have good communication skills, you are organized, rigorous and you would like to join a company in expansion which will be able to answer your needs of career advancement.

altizem is a dynamic and innovative CRO, close to its professionals.

Recognized by the pharmaceutical industry for the quality of our services, we seek for the development of our company. a SAS Programmer

You have a scientific background (BAC+3 to BAC +5) and you have one to two years experience in a pharmaceutical company or in a CRO. You have a good knowledge of SAS (bases, macro and stat).

You speak English well, you have good communication skills, you are organized, rigorous and you would like to join a company in expansion which will be able to answer your needs of career advancement.



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Prostacin, Prostacin

ProstaScint

The only approved imaging agent that specifically targets prostate cancer.

ProstaScint is the only commercially available diagnostic imaging agent approved by the FDA that specifically targets prostate cancer cells that have spread to tissue outside of the prostate gland. It consists of a novel murine monoclonal antibody that, when conjugated to a linker-chelator and radiolabeled, binds distinctly to Prostate Specific Membrane Antigen (PSMA). PSMA is a glycoprotein expressed by prostate epithelium, which is up regulated in prostate cancer. PSMA is expressed on metastatic prostate cancer tissue. Combined with a CT or MRI scan, this fusion imaging study helps to determine the location and extent of metastatic lymph node disease. Knowing whether the prostate cancer is confined to the gland or has spread to the lymph nodes helps physicians determine appropriate patient management.

Product Attributes

The only imaging agent that specifically targets prostate cancer cells

Approved by the US FDA in both newly diagnosed, high risk patients, and patients suspected of having recurrent disease

American Cancer Society specifically recognizes ProstaScint in current prostate cancer diagnosis guidelines

Physician Partners Program

The Physician Partners Program was created to support your needs, by offering a number of benefits, including Physician Imager Training . Overread Service . Reimbursement . and Customer Support .

Scroll down to read Full Indications for Use

ProstaScint Indications for Use: Indium In 111 ProstaScint (Capromab Pendetide) is indicated as a diagnostic imaging agent in newly-diagnosed patients with biopsy-proven prostate cancer, thought to be clinically-localized after standard diagnostic evaluation (eg chest x-ray, bone scan, CT scan, or MRI), who are at high-risk for pelvic lymph node metastases. It is not indicated for patients who are not at high risk. ProstaScint Indications for Use:

Indium In 111 ProstaScint (Capromab Pendetide) is indicated as a diagnostic imaging agent in newly-diagnosed patients with biopsy-proven prostate cancer, thought to be clinically-localized after standard diagnostic evaluation (eg chest x-ray, bone scan, CT scan, or MRI), who are at high-risk for pelvic lymph node metastases. It is not indicated for patients who are not at high risk.

Indium In 111 ProstaScint is also indicated as a diagnostic imaging agent in post-prostatectomy patients with a rising PSA and a negative or equivocal standard metastatic evaluation in whom there is a high clinical suspicion of occult metastatic disease. The imaging performance of Indium In 111 ProstaScint following radiation therapy has not been studied.

The information provided by Indium In 111 ProstaScint imaging should be considered in conjunction with other diagnostic information. Scans that are positive for metastatic disease should be confirmed histologically in patients who are otherwise candidates for surgery or radiation therapy unless medically contraindicated. Scans that are negative for metastatic disease should not be used in lieu of histological confirmation.

ProstaScint is not indicated as a screening tool for carcinoma of the prostate nor for readministration for the purpose of assessment in response to therapy.

Contraindications: Indium In 111 ProstaScint should not be used in patients who are hypersensitive to this or any other product of murine origin or to Indium In 111 chloride.

Warnings: Patient management should not be based on Indium In 111 ProstaScint (Capromab Pendetide) scan results without appropriate confirmatory studies since in the pivotal trials, there was a high rate of false positive and false negative image interpretations (See PRECAUTIONS).

Indium In 111 ProstaScint images should be interpreted only by physicians who have had specific training in Indium In 111 ProstaScint image interpretation (see PRECAUTIONS, IMAGING PRECAUTIONS).

Allergic reactions, including anaphylaxis, can occur in patients who receive murine antibodies. Although serious reactions of this type have not been observed in clinical trials after Indium In 111 ProstaScint administration, medications for the treatment of hypersensitivity reactions should be available during administration of this agent.

Indium In 111 ProstaScint may induce human anti-mouse antibodies which may interfere with some immunoassays, including those used to assay PSA and digoxin (see PRECAUTIONS, DRUG/LABORATORY TEST INTERACTIONS).



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Tpms Sensors, Tmps

TPMS Sensors

Finally, a true 2 sensor TPMS solution. For years, tire stores have asked for a simple solution to solve stocking and servicing over 200 OE TPMS sensors in use. These blank sensors, combined with our P220 tool which holds sensor protocols for over 90% of all sensors on the road today, are the what make […]

Finally, a true 2 sensor TPMS solution. For years, tire stores have asked for a simple solution to solve stocking and servicing over 200 OE TPMS sensors in use. These blank sensors, combined with our P220 tool which holds sensor protocols for over 90% of all sensors on the road today, are the what make […]

You asked for it…. A rubber snap sensor solution. We tried to adopt a snap sensor to our standard sensor housing but it was to heavy and failed the “Smithers Testing”. So we designed a light weight sensor housing that fits all our tools and new programming modules. It has all the same features as […]

You asked for it…. A rubber snap sensor solution. We tried to adopt a snap sensor to our standard sensor housing but it was to heavy and failed the “Smithers Testing”. So we designed a light weight sensor housing that fits all our tools and new programming modules. It has all the same features as […]

About Us

PILOT AUTOMOTIVE is one of the largest providers of aftermarket and commerical auto parts in the united states. For over 30 years, we have provided quality products and built strong partner relationships with companies like AutoZone, Pep Boys, Or'ileys. NAPA, Walmart, Costco and hundreds more.

Commitment To Our Social Communities

We not only get it, we have embrassed it. Through our social communities we hope to help you contribute to and improve not just your PilotTPMS experience but others who are just beginning and need some help. We are committed to offering social platforms to educate, train, overcome problems and listen. A great product is nothing without you.

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Comprar Zorstat (Zocor) Sin Receta, Zorstat

compra Zorstat (Zocor) en linea sin receta

Zorstat (Zocor) Explicacion

Zorstat es definitivamente un inhibidor de la HMG-CoA reductasa.

Zorstat se utiliza con el fin de: la lentitud en la probabilidad de infarto de miocardio, ataque al corazon, asi como la desaparicion a causa de enfermedades del corazon; la lentitud en la probabilidad de infarto de miocardio, ataque al corazon, la congestion del barco torrente sanguineo, o incluso problemas cardiacos provocados por anginas; problemas cardiacos inferiores, asi como los trigliceridos; mejorar las lipoproteinas de alta densidad (HDL, "bueno") cantidades de colesterol.

Zorstat tambien puede ser referido como Imvastatin, Simlup, Simcardis, Ranzolont, Simvador.

Zorstat funciones por la disminucion de la fabricacion de ingredientes grasos especificos en su cuerpo, como el colesterol.

titulo general asociada con Zorstat es en realidad estatinas.

Marca asociada con Zorstat Zorstat es en realidad.

Zorstat (Zocor) Dosis

Zorstat viene en:

5mg Baja Dosis material de friccion

20 mg Mejora Dosis material de friccion class = id "alternar-dosis" = "d40mg">40 mg maximo del material de friccion Dosis

Obtenga Zorstat por via oral.

Obtener Zorstat sin o con las comidas.

Por lo general, no utilizan el pomelo o incluso jugo de frutas de pomelo durante el uso de Zorstat. El consumo de toronja o incluso el consumo de zumo de frutas de pomelo puede aumentar la cantidad de Zorstat en el torrente sanguineo, exactamente lo que podria aumentar los efectos negativos severos.

Si usted desea lograr mejores resultados por lo general no dejar de usar Zorstat, de repente.

Zorstat (Zocor) Careciendo asocia con dosis

Por lo general, no reciben doble dosis. En caso de que salte la dosis que necesita para llevar una vez se tiene en cuenta en lo que respecta a su deficiente. Cuando es hora de la dosis que necesita para llevar a cabo su propia rutina de dosificacion normal.

Zorstat (Zocor)

En el caso de que una sobredosis de Zorstat y que tambien se evita gran usted necesita comprobar hacia fuera su medico o incluso el medico de inmediato.

Zorstat (Zocor) Espacio de almacenamiento

Tienda en temperaturas por debajo de los treinta niveles espaciales D (86 niveles F) de humedad, asi como la temperatura. Mantener cuadro de texto firmemente cerrada. Fortalecer cualquier tipo de medicamento sin tocar a partir del dia de vencimiento. Mantener desde el lograr de los ninos.

Zorstat (Zocor) Efectos negativos

Zorstat ofrece los efectos negativos. El mas tipico tienden a ser:

Material de problemas cardiacos friccion

material de friccion pis oscuro

masa muscular material de friccion molestias

material de friccion dolor

un poco de material de friccion debilidad

heces material de friccion de luz

amarilleamiento asociado con el ojo, asi como los poros y material de friccion de la piel

Mucho menos tipicos y graves efectos negativos en todo el uso de Zorstat: respuestas de reaccion alergica (urticaria, inhalando y exhalando, cuestiones de alergia, asi como la erupcion).

Los efectos negativos son indicaciones se basan en la medicacion que pueda estar utilizando, sino que ademas dependen de su estado de bienestar y otros aspectos.

Zorstat (Zocor) Contraindicaciones

Por lo general no reciben Zorstat si usted es sensible a fin de elementos Zorstat.

Tenga cuidado junto con Zorstat si usted esta esperando otra manera tiene la intencion de tener un hijo. Por lo general, no utilizan una mama medica de alta level00.

Tenga cuidado junto con Zorstat en caso de que se ven afectados por la presion baja arterial baja, problemas renales. contaminacion severa diabetica, problemas en los procesos metabolicos, problemas de basura.

Por lo general, no utilizan suplementos dieteticos de potasio o incluso alternativas de sodio.

Evitar consumir pomelo o incluso el consumo de zumo de frutas de pomelo durante el uso de Zorstat.

Mientras que el uso de Zorstat, es posible realizar evaluaciones de laboratorio (cantidades de colesterol en sangre, evaluaciones de funcionalidad de organos del higado, niveles de creatina fosfoquinasa del torrente sanguineo) para la salud de su bienestar.

Si usted desea lograr mejores resultados, sin efectos negativos, es aconsejable evitar las bebidas alcoholicas.

Hacerse cauteloso si usted esta viajando dispositivo.

Por lo general, no dejar de fumar usando Zorstat, de repente.

Zorstat (Zocor) Preguntas comunes

Queen: ?Que es exactamente Zorstat?

El: Zorstat es definitivamente un inhibidor de la HMG-CoA reductasa. Zorstat se utiliza para disminuir la posibilidad de infarto de miocardio, ataque al corazon, asi como la desaparicion a causa de enfermedades del corazon. Ademas, disminuye el riesgo de infarto de miocardio, ataque al corazon, la congestion del barco torrente sanguineo, o incluso los problemas del corazon provocada por anginas, estos niveles de problemas del corazon, asi como los trigliceridos, asi como aumenta la lipoproteina de alta densidad (HDL, "colesterol bueno") amounts. A

Reina: ?Como puede realmente hace la funcion Zorstat?

El: Zorstat funciones por la disminucion de la fabricacion de ingredientes grasos especificos en su cuerpo, como cholesterol. A

Reina: ?El acceso general?

El: De hecho, en general se puede obtener. Titulo general asociada con Zorstat es en realidad Statins. A

Reina: ?Puedo mezclar bebidas alcoholicas junto con pastillas Zorstat?

El: Numero Normalmente no utilizan bebidas alcoholicas durante el uso Zorstat. A

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The Effect Of Ns-0200 Versus Placebo On Hepatic Fat Content In Patients With Non Alcoholic Fatty Liv

The Effect Of NS-0200 Versus Placebo On Hepatic Fat Content In Patients With Non Alcoholic Fatty Liver Disease

Further study details as provided by NuSirt Biopharma:

Primary Outcome Measures:

Change in hepatic fat [ Time Frame: Baseline, Day 112 ] [ Designated as safety issue: No ]

• To evaluate the change in hepatic fat content assessed by proton-density-fat-fraction (PDFF) employing magnetic resonance imaging (MRI)

Secondary Outcome Measures:

Change in serum alanine aminotransferase (ALT) [ Time Frame: Baseline, Day 112 ] [ Designated as safety issue: No ]

ALT will be examined through standard blood chemistry

Change in circulating cytokeratin 18 [ Time Frame: Baseline, Day 112 ] [ Designated as safety issue: No ]

K18 will be examined through standard blood chemistry

Change in HbA1c [ Time Frame: Baseline, Day 112 ] [ Designated as safety issue: No ]

HbA1c will be examined through standard blood chemistry

Change in fasting glucose [ Time Frame: Baseline, Day 112 ] [ Designated as safety issue: No ]

Fasting glucose will be examined through standard fasting blood chemistry

Change in insulin and insulin sensitivity [ Time Frame: Baseline, Day 112 ] [ Designated as safety issue: No ]

insulin levels will be examined through standard blood chemistry

Change in blood lipids [ Time Frame: Baseline, Day 112 ] [ Designated as safety issue: No ]

Lipid levels such as cholesterol LDL, HDL, triglycerides will be examined by standard blood chemistry

Change in C-reactive protein [ Time Frame: Baseline, Day 112 ] [ Designated as safety issue: No ]

CRP levels will be examined by standard blood chemistry

Number of participants with treatment related adverse events [ Time Frame: Baseline, Day 112 ] [ Designated as safety issue: No ]

Patients will be monitored and asked about any adverse events or problems they encounter as a result of the study drug

Age 18-75 at study entry.

Is male, or female and, if female, meets all of the following criteria:

Not breastfeeding

Post-menopausal or negative serum pregnancy test result (human chorionic gonadotropin, beta subunit [β-hCG]) at Screening /Visit 1 (Day-14/Week-2) (not required for hysterectomized females)

If of childbearing potential (including peri-menopausal women who have had a menstrual period within one year) must practice and be willing to continue to practice appropriate birth control (defined as a method which results in a low failure rate, i. e. less than 1% per year, when used consistently and correctly, such as double barrier methods [male condom with spermicide, with or without cervical cap or diaphragm], implants, injectables, oral contraceptives [must have been using for at least the last 3 months], some intrauterine contraceptive devices, tubal ligation, or in an established relationship with a vasectomized partner) during the entire duration of the study.

Has been diagnosed with NAFLD via CT (positive for excess liver fat), ultrasound (positive for excess liver fat), MRI (PDFF showing > 15% liver fat) or via biopsy (showing >33% fat) within the past six months. If diagnosis was between 3 and 6 months prior to Screening, an ultrasound (positive for excess liver fat) is required prior to the Screening /Visit 1 (Day-14/Week-2) MRI.

Has liver fat (as measured by PDFF via MRI) greater than 15% at Screening/Visit 2 (Day-7/Week-1)

Has had ALT levels >30 U/L for men, >19 U/L for women measured within 8 weeks of enrollment

Has an HbA1c equal to or less than 9% at Screening /Visit 1 (Day-14/Week-2)

Has a BMI between 25kg/m2 and 40 kg/m2

Otherwise stable health for preceding twelve weeks

Clinical laboratory tests (hematology, clinical chemistry, and urinalysis) either normal or with abnormalities consistent with NAFLD.

Is able to read, understand, and sign the informed consent forms (ICF) and, when applicable, an authorization to use and disclose protected health information form (consistent with Health Insurance Portability and Accountability Act of 1996 [HIPAA] legislation), communicate with the investigator, and understand and comply with protocol requirements.

Clinically significant renal dysfunction defined as a serum creatinine concentration >1.4 mg/dL (females) or >1.6 mg/dL (males) or a blood urea nitrogen concentration >45 mg/dL at screening.

Use of any of the following medications:

Metformin

Combination drugs that include Metformin

Sildenafil

Tadalafil

Vardenafil

Pioglitazone

Rosiglitazone

Short acting insulins

An alpha blocker

Oral nitrates

Medications associated with increased hepatic steatosis

Insulins

OCT2/MATE inhibitors (e. g. cimetidine, quinidine, and pyrimethamine)

Methotrexate

Tamoxifen

Corticosteroids (Nasal steroids are allowed if the subject has been on a stable dose for the past 12 weeks and the dose employed does not exceed the maximal recommended dose.)

Estrogens

Amiodarone

Valproic acid

Coumadin

Isoniazide

Nucleoside analogues used for the treatment of HIV infections

Any dietary supplement other than multi-vitamins

Evidence of significant alcohol consumption (defined as >7 drinks/week for females and >14 drinks/week for males) within 6 months prior to randomization or presence or suspicion of other forms of chronic liver disease (e. g. cirrhosis, autoimmune hepatitis (>1:160 ANA), Wilson's disease, Hemochromatosis (Ferritin >1000 ug/L and percent iron saturation >45%), hepatitis A, B or C)

Has a clinically significant medical condition that could potentially affect study participation and/or personal well-being, as judged by the investigator, including but not limited to the following conditions:

Unable to undergo MRI or contraindications for MRI procedure

History of cardio - or cerebro-vascular disease event within the previous 6 months

Requires anti-coagulation therapy

Gastrointestinal disorders including, but not limited to, the following: pancreatitis, inflammatory bowel disease, or other diseases associated with malabsorption or persistent abdominal discomfort

Endocrine disorders other than type 2 diabetes and hypothyroidism on stable replacement therapy

Chronic infection (e. g. tuberculosis, human immunodeficiency virus infection, hepatitis A virus, hepatitis B virus, or hepatitis C virus)

Neurological or psychiatric diseases that preclude valid execution of informed consent or may interfere with the subject's compliance with study procedures (e. g. major depressive disorder within the last 2 years, a history of suicidal behavior in the last 3 months)

History of other psychiatric disorders including schizophrenia and bipolar disorder)

Participation in a weight loss program within the past 3 months.

Weight change ≥5% during the past month.

History of substance abuse (including alcohol abuse as defined above) in the past 3 months or a positive screen for drugs of abuse or alcohol at screening.

Has received any investigational drug within 3 months of Screening.

Has donated blood within 3 months before Screening or is planning to donate blood during the study.

Has had a serious infection, such as pneumonia in the previous 12 weeks

Has known allergies or hypersensitivity to metformin, sildenafil or leucine

Is an immediate family member (spouse, parent, child, or sibling; biological or legally adopted) of personnel directly affiliated with the study at the clinical study site, or NuSirt Biopharma.

Is employed by NuSirt Biopharma (defined as an employee, temporary contract worker, or designee responsible for the conduct of the study).

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials. gov identifier: NCT02546609



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Cumar - Building Supplies - 69 Norman St, Everett, Ma - Phone Number, Cumar

Cumar

STAY AWAY FROM THIS COMPANY.

DO NOT BE FOOLED by their beautiful show room and large variety of stone options. In comparison to the other… Read More

STAY AWAY FROM THIS COMPANY.

DO NOT BE FOOLED by their beautiful show room and large variety of stone options. In comparison to the other options in the area, they are fantastic when it comes to communication -- they return your calls/emails in a timely fashion and they answer your questions. BUT they don't stand behind their work and take responsibility when they make mistakes.

I hired them to do a small project in my bathroom (it involved cutting four pieces from the same slab to match each other). The afternoon before my scheduled installation I received a call because my pieces were not going to be ready on time. I asked when we could reschedule the installation, and they called me back to let me know someone would stay late to finish the piece on time.

The countertop came out beautiful BUT the sink was installed very slightly off-center. It's admittedly pretty slight, but for such an expensive project, it should be PERFECT!

The shelves were supposed to be polished on the top and the bottom, but instead were only polished on one side and honed on the other -- I never got a response from them when I asked about it.

There were very serious issues concerning the final piece. During the templating, they damanged my wood window sill I was replacing (I had initially planned to repurpose this piece. ). Upon mentioning this to the salesman, he said "it's difficult to make a template." If it's too difficult for them to do their job without damaging my personal property, perhaps they should not be in this business? The sill template they made was not shaped properly to fit where it needed to be installed. The template had multiple irregular non-straight lines and small perpendicular cuts where there should not have been and it wasn't even symmetrical. It looked like a child had made it. When I requested that these extraneous cuts be omitted when cutting the marble I was told that the template was made by a professional, which I am not, so we should not change it. He said that the template may not necessarily be an exact match to the space because they need to account for some small amount of space in order for it to fit in the spot. I, naively, listened. (In speaking with other experts later, I learned that this explanation was completely bogus and incorrect: the template should be an EXACT match to the space and that this is why they come and measure it prior to cutting the stone. And that's why the template work itself is not cheap!) I discovered a large crack through the slab (front to back) during the layout. To assuage my concerns that my pieces would be cut through the crack, the salesman marked it with X's. Ultimately, the piece was cut about a foot from where I agreed during the layout. It included the crack and excluded a dark, beautiful portion of the veins in the natural stone. Their excuse was that the layout was done incorrectly and that in order to fit the piece on the slab, it had to be moved over. They passed off the supposedly erroneous layout as an error made on my own behalf eventhough the layout was based on the template they made and the outline was drawn by their salesman -- I only told him where to draw. Furthermore, this is no excuse to include a portion of the stone which is SPECIFICALLY marked to be EXCLUDED. If there was a problem with the layout, it needed to be communicated to me prior to cutting the stone. Finally, the sill did not fit where it needed to be installed because of the sloppy, irregular shape (which, they were proud to point out, was the same shape as the template). Cumar promised to fix the problem and made a proposal which would have somewhat improved the situation, but at an additional cost to me. I informed them that this proposal was a start for them to amend the situation, eventhough I found it grossly inappropriate that their errors would be at my expense. (At this point I just wanted it to be done and done well!) They got back to me to inform me they will do no further business with me (including this botched, outstanding project I had hired them to complete). They demanded that I pay them for the charge for the windowsill template which was used to exactly cut the sill that does not fit in my wall.

GO ELSEWHERE TO GET YOUR STONE WORK DONE IF YOU WANT IT DONE RIGHT ANDY BY A COMPANY WHO WILL STAND BEHIND THIER WORK!

I have since hired an expert to determine if the sill piece can be salvaged. He had a solution for the crack, but in order for the piece to fit, portions would need to be trimmed, and large gaps would need to be filled with grout -- completely unacceptable!

In talking to other people in the stone business, I've discovered that this project is not the only example in which Cumar failed to properly template their pieces and in which they did not stand behind their work.

See all 4 reviews in the app!

D K.

STAY AWAY FROM THIS COMPANY.

DO NOT BE FOOLED by their beautiful show room and large variety of stone options. In comparison to the other options in the area, they are fantastic when it comes to communication -- they return your calls/emails in a timely fashion and they answer your questions. BUT they don't stand behind their work and take responsibility when they make mistakes.

I hired them to do a small project in my bathroom (it involved cutting four pieces from the same slab to match each other). The afternoon before my scheduled installation I received a call because my pieces were not going to be ready on time. I asked when we could reschedule the installation, and they called me back to let me know someone would stay late to finish the piece on time.

The countertop came out beautiful BUT the sink was installed very slightly off-center. It's admittedly pretty slight, but for such an expensive project, it should be PERFECT!

The shelves were supposed to be polished on the top and the bottom, but instead were only polished on one side and honed on the other -- I never got a response from them when I asked about it.

There were very serious issues concerning the final piece. During the templating, they damanged my wood window sill I was replacing (I had initially planned to repurpose this piece. ). Upon mentioning this to the salesman, he said "it's difficult to make a template." If it's too difficult for them to do their job without damaging my personal property, perhaps they should not be in this business? The sill template they made was not shaped properly to fit where it needed to be installed. The template had multiple irregular non-straight lines and small perpendicular cuts where there should not have been and it wasn't even symmetrical. It looked like a child had made it. When I requested that these extraneous cuts be omitted when cutting the marble I was told that the template was made by a professional, which I am not, so we should not change it. He said that the template may not necessarily be an exact match to the space because they need to account for some small amount of space in order for it to fit in the spot. I, naively, listened. (In speaking with other experts later, I learned that this explanation was completely bogus and incorrect: the template should be an EXACT match to the space and that this is why they come and measure it prior to cutting the stone. And that's why the template work itself is not cheap!) I discovered a large crack through the slab (front to back) during the layout. To assuage my concerns that my pieces would be cut through the crack, the salesman marked it with X's. Ultimately, the piece was cut about a foot from where I agreed during the layout. It included the crack and excluded a dark, beautiful portion of the veins in the natural stone. Their excuse was that the layout was done incorrectly and that in order to fit the piece on the slab, it had to be moved over. They passed off the supposedly erroneous layout as an error made on my own behalf eventhough the layout was based on the template they made and the outline was drawn by their salesman -- I only told him where to draw. Furthermore, this is no excuse to include a portion of the stone which is SPECIFICALLY marked to be EXCLUDED. If there was a problem with the layout, it needed to be communicated to me prior to cutting the stone. Finally, the sill did not fit where it needed to be installed because of the sloppy, irregular shape (which, they were proud to point out, was the same shape as the template). Cumar promised to fix the problem and made a proposal which would have somewhat improved the situation, but at an additional cost to me. I informed them that this proposal was a start for them to amend the situation, eventhough I found it grossly inappropriate that their errors would be at my expense. (At this point I just wanted it to be done and done well!) They got back to me to inform me they will do no further business with me (including this botched, outstanding project I had hired them to complete). They demanded that I pay them for the charge for the windowsill template which was used to exactly cut the sill that does not fit in my wall.

GO ELSEWHERE TO GET YOUR STONE WORK DONE IF YOU WANT IT DONE RIGHT ANDY BY A COMPANY WHO WILL STAND BEHIND THIER WORK!

I have since hired an expert to determine if the sill piece can be salvaged. He had a solution for the crack, but in order for the piece to fit, portions would need to be trimmed, and large gaps would need to be filled with grout -- completely unacceptable!

In talking to other people in the stone business, I've discovered that this project is not the only example in which Cumar failed to properly template their pieces and in which they did not stand behind their work.

Kris M.

Short Answer: Do not go here for your Granite counter tops.

We went here, and at first, everyone seemed quite nice. Jared, our sales rep, was a little slow to get back to us on things, but the price beat everyone else's. That was for a reason.

When our counter top FINALLY came (it took hassling them to get templating done, then they have about a 4 week lead time until the granite is cut and can be installed) it didn't fit properly. There were huge, ugly seams, as well as half inch by inch gaps at the edges near the front of the counter that they filled with NEON green putty (our granite was green).

We called Jared the next morning and emailed him pictures of the horrendous counter, and even he acknowledged it was cut wrong. He said they would cut new pieces and come back to fix the work. That was two and a half months ago, and we haven't been able to get him on the phone since. Our $10,000 counter top is ugly, and it seems we have no recourse but to complain on Yelp. Do not believe them when they tell you "We are not done until you are fully satisfied with your new project."

Kerry R.

I would go back to Cumar in a heartbeat! I also went through Jared for the counters in our Penthouse apartment. We needed a top quality product and look, and that's just what he delivered. I NEVER HAD A PROBLEM REACHING JARED. EVER!!

4 weeks lead time is pretty reasonable. scheduling a template can be difficult when you are dealing with people's work schedules and seams are to be expected if you don't SPECIFICALLY ask for one solid piece like we did.

I have referred many friends to him, and they all are very happy with the end results. Thank you Jared. and Cumar.

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Example: There are a few times in life when a meal is so expertly crafted and planned that it is nothing short of genius. Last night, I had one of those meals - the Mahi Mahi.

The dish was excellently prepared. Grilled, juicy, and fresh without a hint of fishiness. A glaze of tangerine sauce brought a hint of tart sweetness. The fish was placed on a mound of sweet plantain rice. The combination of the fish and rice alone was to die for!

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Cumar Marble and Granite Stones for Countertops, Granite Counters, Vanity Counters, Vanity Countertops, Stone Fireplace, Kitchens, Bathrooms, Showers, Stone Sinks

History

Established in 1992.

Cumar, Inc. founded in 1992, has a staff with experience and knowledge well beyond their eighteen years in business.

Cumar opened the present facility in 1994 on Norman Street in Everett, Massachusetts and has expanded the warehouse, workshop, office and showroom areas to become one of the largest stone fabrication shops in New England.

Owner, Angelo "Ivo" Cubi, born and raised in Italy, learned first hand what it means to work with marble. "For seven generations, my family has been in the marble business," he says.

Building on this experience, Ivo founded his own company, Cumar, Inc, located in Everett, MA. With Cumar, Ivo has made strides in bringing the highest quality in marble, granite and many other fine stones from around the world to both commercial and residential clients.

Each year Ivo travels extensively throughout the world to hand select the product for Cumar. Together with our professional stone cutters and detailers, we can do most any project you can dream of. Ampl

Meet the Manager: Dave C.

Dave Connor is the current General Manager at CUMAR, Inc.



Buy Online Cumar - Building Supplies - 69 Norman St, Everett, Ma - Phone Number, Cumar

Buy Gelbiotic - Fusidic - Online Without Prescriptions, Gelbiotic

Fucidin (Gelbiotic)

Fucidin cream is used to treat skin infections such as impetigo, infected eczema or infected wounds or cuts. It works by killing the organisms that have caused the infection.

Use Fucidin cream as directed by your doctor.

Fucidin cream is for use on the skin only. Do not get it in your eyes.

Wash your hands with soap and water before and after using this medicine.

Apply a thin layer of this medicine to the affected area of the skin 3 or 4 times daily until the infection has cleared. Rub it in gently.

Do not use cosmetics or other skin care products on the treated areas.

Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.

If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.

If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

If you miss a dose of Fucidin cream, skip the missed dose and go back to your regular dosing schedule. Do not apply a double dose to make up for a missed one.

Ask your health care provider any questions you may have about how to use Fucidin cream.

Store Fucidin cream at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Fucidin cream out of the reach of children and away from pets.

Active Ingredient: Fusidic acid.

Other Ingredients: White soft paraffin, Liquid paraffin, Butylated hydroxyanisole, Cetanol, Glycerol, Potassium sorbate, Purified water, Polysorbate 60.

Fusidic acid belongs to a class of medications known as antibiotics.

you are allergic to any ingredient in Fucidin cream.

Some medical conditions may interact with Fucidin cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances.

Some medicines may interact with Fucidin cream. There are no known important interactions between Fucidin cream and other medicines. If you experience any unusual symptoms while using Fucidin cream and other medicines you should tell your health care provider.

Pregnancy : This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication may pass into breast milk. If you are a breast-feeding mother and are using fusidic acid, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

All medicines may cause side effects, but many people have no, or minor, side effects.

Everyone's reaction to a medicine is different. It is difficult to predict which side effects

you will have from taking a particular medicine, or whether you will have any side effects

at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

Uncommon: More than 1 in 1000 people who use Fucidin cream:

Dermatitis (skin sensitivity reactions may occur if Fucidin cream is used for long

periods of time), irritation at the site of application (reactions include pain, redness of the skin, stinging, and burning sensations), itching, skin rash or rashes.

Rare: More than 1 in 10,000 people who use Fucidin cream:

Eye or eyesight problems, hypersensitivity reactions.

The frequency of these sideeffects is unknown:

Angioedema, antibiotic resistance to fusidic acid (this may happen if Fucidin cream is used for long periods of time), eczema, oedema around the eyes, urticaria.

If you feel unwell or if you have concerns about a side effect, you will need to seek advice. If you feel very ill, get medical help straight away.

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Somac Heartburn Relief Tablets, Somac

Somac® Heartburn Relief Tablets

Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about Somac Heartburn Relief.

It does not contain all the available information. It does not take the place of talking to your pharmacist or doctor.

The information in this leaflet was last updated on the date listed on the final page. More recent information on the medicine may be available.

You should ensure that you speak to your pharmacist or doctor to obtain the most up to date information on this medicine.

Those updates may contain important information about the medicine and its use of which you should be aware.

If you have any concerns about taking this medicine, ask your pharmacist or doctor.

Keep this leaflet with the medicine. You may need to read it again.

What Somac Heartburn Relief is used for

Somac Heartburn Relief is used for lasting symptomatic relief of frequent heartburn and stomach acid complaints due to gastro-oesophageal reflux disease (GORD).

These symptoms can be caused by “washing back” (reflux) of food and acid from the stomach into the food pipe, also known as the oesophagus.

Reflux can cause a burning sensation in the chest rising up to the throat, also known as heartburn.

Frequent heartburn is when you have heartburn for two or more days a week. Heartburn that occurs frequently is a typical symptom of GORD.

Somac Heartburn Relief is not the right medicine for you if you suffer heartburn only occasionally (one episode of heartburn a week or less), or if you want immediate relief of heartburn.

Somac Heartburn Relief will start to suppress acid within a few hours, however it is not intended to provide instant symptom relief. For effective, lasting relief, you should take a full course of Somac Heartburn Relief (see ‘How to take Somac Heartburn Relief’ below).

Somac Heartburn Relief belongs to a group of medicines called proton pump inhibitors (PPIs). This medicine works by decreasing the amount of acid the stomach makes to give relief from the symptoms.

Somac Heartburn Relief is not addictive.

Somac Heartburn Relief is for use by adults over 18 years of age.

Do not give Somac Heartburn Relief to children or adolescents under 18 years of age.

Before you start to take Somac Heartburn Relief

When you must not take it

Do not take Somac Heartburn Relief if you:

have an allergy to pantoprazole, any other PPI (such as omeprazole, rabeprazole or lansoprazole) or any of the ingredients listed at the end of this leaflet. Some symptoms of an allergic reaction include skin rash, itching, shortness of breath or swelling of the face, lips or tongue, which may cause difficulty in swallowing or breathing.

have severe liver disease or cirrhosis

have recently had trouble swallowing, pain when swallowing, persistent vomiting or experienced unintended weight loss

have recently vomited blood, had black stools or notice blood in your stools

are taking atazanavir or nelfinavir (anti-viral medications)

are pregnant, intend to become pregnant, are breast-feeding or wish to start breast-feeding.

Do not take it after the expiry date (EXP) printed on the pack or if the packaging is damaged or shows signs of tampering. If it has expired or is damaged return it to your pharmacist for disposal.

Before you start to take it

Tell your pharmacist or doctor if you have:

jaundice, liver problems or anaemia

a feeling of weakness or you look pale

previously taken heartburn / indigestion medications continuously for 4 or more weeks

persisting heartburn symptoms despite taking Somac Heartburn Relief (or other similar medicines) continuously for 2 weeks, or your symptoms have recently changed

been told by your doctor that you have a stomach ulcer, or gastrointestinal surgery is planned

heartburn/ indigestion symptoms for the first time and you are over 40 years of age

a scheduled endoscopy (investigation of your stomach lining performed by a specialist)

any allergies to any medicines or other substances, such as foods, preservatives or dyes.

Your pharmacist or doctor can provide specific advice on whether you should take Somac Heartburn Relief.

Tell your pharmacist or doctor if you have or have had any other medical conditions, or you are pregnant, intend to become pregnant, are breast-feeding or wish to start breast-feeding.

Taking other medicines

Tell your pharmacist or doctor if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines and Somac Heartburn Relief may interfere with each other. These include:

warfarin, phenprocoumon - medicines used to prevent blood clots (blood thinners)

atazanavir, nelfinavir - medicines used to treat viral infections such as HIV

ketoconazole, itraconazole, posaconazole - medicines used to treat fungal infections

methotrexate - a medicine used to treat arthritis and some types of cancer

erlotinib or related medicines used to treat cancer

tacrolimus, mycophenolate mofetil - medicines used to suppress the immune system

fluvoxamine - a medicine used to treat anxiety and depression

These medicines may be affected by Somac Heartburn Relief, or may affect how well it works. You may need to use different amounts of your medicine, or take different medicines.

Your pharmacist or doctor has more information on medicines to be careful with or to avoid while taking Somac Heartburn Relief.

How to take Somac Heartburn Relief

The directions for use are included on the Medicine Information panel on the pack.

If you do not understand the instructions on the pack, ask your pharmacist or doctor for help.

Follow all directions given to you by your pharmacist or doctor. They may differ from the information contained in this leaflet.

How to take it

Take one Somac Heartburn Relief tablet every day (once every 24 hours).

Swallow your tablets whole with a little water, with or without food.

Do not crush or chew the tablets. Somac Heartburn Relief tablets have a special coating to protect them from the acid contents of your stomach. For Somac Heartburn Relief to work effectively, this coating must not be broken.

How long to take it

For effective, lasting relief, take Somac Heartburn Relief strictly according to the directions on your pack.

Somac Heartburn Relief tablets should be taken for at least seven days, and up to 14 days.

If you purchased the pack containing 7 days’ supply and you need to take it for longer than 7 days, ask your pharmacist for advice.

Do not take beyond 14 days without consulting your doctor.

Somac Heartburn Relief is not intended to provide instant relief from your heartburn/ indigestion symptoms.

If you are not sure, ask your pharmacist or doctor how to take your medicine.

If you forget to take it

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Otherwise, take it as soon as you remember, and then go back to taking it as you would normally.

Do not take a double dose to make up for the dose that you missed. This may increase the chance of you getting an unwanted side effect.

If you are not sure what to do, ask your pharmacist or doctor.

If you have trouble remembering to take your medicine, ask your pharmacist for some hints.

If you take too much (overdose)

Immediately telephone your doctor or Poisons Information Centre for advice (telephone Australia 13 11 26 or New Zealand 0800 764 766), go to Accident and Emergency at your nearest hospital, if you or anyone else may have taken too much Somac Heartburn Relief. Do this even if there are no signs of discomfort or poisoning. Urgent medical attention may be needed.

While you are taking Somac Heartburn Relief

Things you must do

Tell any other doctors, dentists and pharmacists who treat you that you are taking this medicine.

If you are going to have surgery or an endoscopy, tell your doctor that you are taking Somac Heartburn Relief.

If you become pregnant while you are taking this medicine, tell your doctor or pharmacist immediately.

Tell your doctor or pharmacist if you do not feel better while taking Somac Heartburn Relief. If your symptoms recur within 2 weeks of completing your course, consult your doctor. Further investigation may be recommended.

If you are about to have any blood tests, tell your doctor that you are taking this medicine. It may interfere with the results of some tests.

Things you must not do

Somac Heartburn Relief may cause dizziness and visual disturbances. If affected, do not drive or operate machinery.

Things that may help your condition

Some self-help measures suggested below may help your condition. Your pharmacist or doctor can provide more information about these measures.

Alcohol - you may be advised to limit your alcohol intake.

Aspirin and many other medicines used to treat arthritis, period pain, headaches - these medicines may irritate the stomach and may make your heartburn/ indigestion symptoms worse. Your pharmacist or doctor may suggest other medicines you can take.

Caffeine - you may be advised to limit the number of drinks which contain caffeine, such as coffee, tea, cocoa and cola drinks, because they contain ingredients that may irritate your stomach.

Eating habits - eat smaller, more frequent meals. Eat slowly and chew your food carefully. Try not to rush at meal times.

Smoking - it is advisable for you to stop smoking or at least cut down.

Weight - you may be advised that losing some weight will help your reflux/ indigestion symptoms.

Side effects

All medicines have some unwanted side effects. Sometimes they are serious, but most of the time they are not.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

Tell your pharmacist or doctor if you notice any of the following while taking Somac Heartburn Relief and they worry you:

headache or dizziness

diarrhoea, constipation, nausea or vomiting

pain, discomfort or excessive gas in the stomach or bowel

indigestion

mild weakness, tiredness or sleep disturbances

increased sweating or body temperature

blurred vision, dry mouth

metallic taste

mild skin reactions such as itchiness and rash

These are the more common side effects of Somac Heartburn Relief. It helps most people with heartburn/ indigestion, but it has been uncommonly associated with such unwanted side effects.

See your pharmacist or doctor immediately if you notice any of the following:

unusual tiredness, weakness, dizziness or fainting

chest pain, fast heartbeat, shortness of breath

loss of appetite, feeling generally unwell, fever, itching, yellowing of the skin and eyes, and dark coloured urine or bowel movements

blood in the urine

increased or decreased need to urinate

bleeding or bruising more easily than normal

skin problems such as itchiness and rash or swelling, blistering or peeling of the skin

swelling of the face, lips, mouth, tongue or throat which may cause difficulty in swallowing or breathing

frequent symptoms of infections such as fever, severe chills, sore throat or mouth ulcers

high blood pressure

water retention, swelling

depression, confusion or anxiety

bone fracture of the hip, wrist or spine (mainly a risk in people who take high doses of PPIs or use them long term (a year or longer))

symptoms such as seizures, abnormal or fast heartbeat or jerking/shaking movements. These can be a sign of low magnesium levels in your blood

severe and/or persistent diarrhoea, because this medicine has been associated with a small increase in infectious diarrhoea

The above list includes serious side effects that may require medical attention. Serious side effects are rare or very rare.

Tell your pharmacist or doctor if you notice anything else that is making you feel unwell. Other side effects not listed above may occur in some people.

Ask your pharmacist or doctor if you do not understand some of the information in this list.

After taking Somac Heartburn Relief

Storage

Keep your tablets in their blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep the medicine in a cool dry place where the temperature stays below 30°C.

Do not store it or any other medicines in the bathroom, near a sink or windowsill. Do not leave it in the car. Heat and dampness can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground, is a good place to store medicines.

Disposal

If you stop taking this medicine or if the tablets have passed their expiry date, ask your pharmacist what to do with any tablets that are left over.

Product description

What it looks like

Somac Heartburn Relief is available as a 20 mg tablet. The tablets have an acid-resistant coating called an enteric coating.

The tablets are yellow and oval shaped, marked with ‘P20’ on one side.

Somac Heartburn Relief tablets are available in blister packs containing 7 and 14 tablets.

Ingredients

Somac Heartburn Relief tablets contain the equivalent of 20 mg pantoprazole.

Somac Heartburn Relief tablets also contain:

sodium carbonate anhydrous

mannitol

crospovidone

povidone

calcium stearate

hypromellose

titanium dioxide

iron oxide yellow

propylene glycol

methacrylic acid copolymer

polysorbate 80

sodium lauryl sulfate

triethyl citrate

opacode monogramming ink S-1-16530 Brown

Somac Heartburn Relief tablets do not contain gluten, lactose, sucrose, tartrazine or other azo dyes.

Supplier

Somac Heartburn Relief tablets are supplied in Australia by: Takeda Pharmaceuticals Australia Pty Ltd 2-4 Lyonpark Road Macquarie Park NSW 2113 Ph: 1800 675 957

Australian Registration Numbers Pharmacy Only Medicine (7 tablets) - AUST R 234279 Pharmacist Only Medicine (14 tablets) - AUST R 154252

®Registered trademark of Takeda.

This leaflet was prepared in May 2015.

Published by MIMS September 2016

Consumers should be aware that the information provided by the Consumer Medicines Information (CMI) search (CMI Search) is for information purposes only and consumers should continue to obtain professional advice from a qualified healthcare professional regarding any condition for which they have searched for CMI. CMIs are provided by MIMS Australia. CMI is supplied by the relevant pharmaceutical company for each consumer medical product. All copyright and responsibility for CMI is that of the relevant pharmaceutical company. MIMS Australia uses its best endeavours to ensure that at the time of publishing, as indicated on the publishing date for each resource (e. g. Published by MIMS/myDr January 2007), the CMI provided was complete to the best of MIMS Australia's knowledge. The CMI and the CMI Search are not intended to be used by consumers to diagnose, treat, cure or prevent any disease or for any therapeutic purpose. Cirrus Media Pty Limited, its servants and agents shall not be responsible for the continued currency of the CMI, or for any errors, omissions or inaccuracies in the CMI and/or the CMI Search whether arising from negligence or otherwise or from any other consequence arising there from.

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Claribiot

CLARIBIOT Polvo para suspensi?n Tabletas CLARITROMICINA

COMPOSICIÓN TABLETAS Cada tableta contiene: Claritromicina 500 mg Excipientes, c. s. POLVO PARA SUSPENSIÓN ORAL Cada 100 mL de suspensión reconstituida contienen: 250 mg/5 mL 125 mg/5 mL Claritromicina microencapsulada* equivalente a claritromicina base 5000 mg 2500 mg Excipientes, c. s. c. s. Cada 5 mL de suspensión reconstituida contienen: 250 mg/5 mL 125 mg/5 mL Claritromicina microencapsulada* equivalente a claritromicina base 250 mg 125 mg Excipientes, c. s. c. s.

ACCIÓN FARMACOLÓGICA CLARIBIOT® cuyo principio activo es la claritromicina es un antibiótico macrólido con una actividad in vitro frente a muchos organismos aerobios y anaerobios grampositivos y gramnegativos. Las concentraciones inhibitorias mínimas (CMI) de la claritromicina son generalmente de 2 a 4 partes menores que las CMI de eritromicina contra las bacterias grampositivas, así como contra la mayor parte de especies de estreptococos y Staphylococcus aureus meticilinosensibles. Claritromicina es bactericida contra S. pyogenes y S. pneumoniae . La actividad de la eritromicina es dos veces mayor que de la claritromicina frente a Haemophilus influenzae ; sin embargo el metabolito activo de la claritromicina, 14-hidroxiclaritromicina, es más activo que la eritromicina. Cuando claritromicina y 14-hidroxiclaritromicina se combinan, sus CMI son de 2 a 4 partes menores que de la eritromicina, sugiriéndose una actividad in vitro o sinérgica frente a Haemophilus influenzae . Claritromicina se une a la subunidad ribosomal 50S del ribosoma de organismos susceptibles; de ese modo inhibe la síntesis proteica. Claritromicina se absorbe muy bien en el tracto gastrointestinal; es estable en ácido gástrico, su biodisponibilidad es aproximadamente 55% en voluntarios sanos. En adultos la biodisponibilidad de la suspensión oral es similar a la de las tabletas. Se distribuye ampliamente en tejidos y fluidos. Presenta un metabolismo hepático. Aproximadamente, 30% de la dosis de 500 mg en tabletas, dada 2 veces al día, es excretada en la orina en forma inalterada y un 40% de la dosis de 250 mg suspensión oral, dada 2 veces al día, es excretada en la orina como claritromicina.

INDICACIONES: CLARIBIOT® está indicado en el tratamiento de las siguientes infecciones cuando son causadas por organismos susceptibles: • En el tratamiento de bronquitis, exacerbaciones bacterianas de la misma. • Tratamiento de otitis media aguda. • Tratamiento de faringitis estreptocócica. • Tratamiento de neumonía causada por micoplasmas. • Tratamiento de neumonía estreptocócica. • Tratamiento de sinusitis maxilar aguda. • Tratamiento de infecciones de la piel y tejidos blandos, claritromicina está indicada en el tratamiento de estos casos cuando son causados por organismos susceptibles. • La claritromicina tiene una actividad in vitro frente a Legionella pneumophila . Moraxella (Branhamella) catarrhalis . Chlamydia trachomatis y Ureaplasma urealyticum . Claritromicina también tiene una buena actividad in vitro frente a Helicobacter pylori y ha sido clínicamente efectivo, en el tratamiento de úlcera duodenal cuando es combinado con omeprazol.

INTERACCIONES CON OTROS MEDICAMENTOS Y CON ALIMENTOS: Las siguientes interacciones y/o problemas relacionados han sido seleccionadas en base a su significancia clínica potencial: Carbamazepina: La administración de carbamazepina con claritromicina ha presentado un incremento significativo de la concentración plasmática de carbamazepina; deberán ser monitorizados los niveles séricos de carbamazepina. Digoxina: La administración simultánea de digoxina con claritromicina ha presentado un incremento de las concentraciones séricas de digoxina; es recomendable la monitorización de los niveles séricos de digoxina en los pacientes que reciben simultáneamente claritromicina y digoxina. Rifampicina: El uso simultáneo de rifampicina y claritromicina disminuye la concentración sérica de claritromicina en menos del 50%. Terfenadina: El uso simultáneo de claritromicina y terfenadina, puede incrementar la concentración plasmática de terfenadina y de su metabolito activo en 2 ó 3 veces; debería ser evitado su uso simultáneo. Teofilina: La administración simultánea con claritromicina ha incrementado el área bajo la curva de concentración plasmática-tiempo (AUC) de teofilina en un 17%; la monitorización de los niveles séricos de teofilina es recomendable en pacientes que estén recibiendo altas dosis de teofilina o en pacientes con niveles séricos de teofilina con el más alto rango terapéutico. Warfarina: La administración simultánea con claritromicina ha evidenciado potenciar los efectos de warfarina, deberá monitorizarse el tiempo de protrombina. Zidovudina: Dosis de zidovudina y claritromicina deberían ser tomadas por separado en un lapso de por lo menos 4 horas.

CONTRAINDICACIONES Está contraindicado en pacientes con hipersensibilidad a eritromicina o a otros macrólidos.

PRECAUCIONES • Pacientes quienes presentan hipersensibilidad a la eritromicina u otros macrólidos pueden también presentar hipersensibilidad a la claritromicina. • Carcinogenicidad/Mutagenicidad: No se ha establecido. • Embarazo/Reproducción: Estudios adecuados y bien controlados no han sido realizados en humanos. • Lactancia: La claritromicina y su metabolito activo son distribuidos en la leche materna. • Pediatría: Estudios adecuados de la relación de la edad y los efectos de la claritromicina no han sido realizados en niños hasta 6 meses de edad. La claritromicina en suspensión oral ha sido estudiada en niños de 6 meses a 12 años de edad y parece ser bien tolerada. • Geriatría: En un estudio realizado en sujetos ancianos sanos, determinaron que no hubo un incremento de efectos colaterales en comparación con sujetos más jóvenes. Los pacientes ancianos con disfunción renal severa pueden requerir una disminución de la dosis.

INCOMPATIBILIDADES: No se conocen reportes de incompatibilidades.

REACCIONES ADVERSAS Las siguientes reacciones adversas han sido seleccionadas teniendo como base su significancia clínica potencial. Requieren atención médica: • Incidencia rara: – Colitis por Clostridium difficile . Calambres estomacales o abdominales severos y dolor; distensión abdominal; diarrea líquida severa, la cual puede ser también sanguinolenta; fiebre. – Hepatotoxicidad: Fiebre; náuseas y vómitos; piel u ojos amarillos. – Hipersensibilidad: Respiración dificultosa; rash cutáneo y picazón. – Trombocitopenia. Requieren atención médica solamente si persisten o son molestos: • Incidencia menos frecuente: – Alteración del gusto: 3%. – Molestias abdominales como malestar abdominal o dolor, diarrea, náuseas, vómitos: De 2 a 3%. – Dolor de cabeza.

ADVERTENCIAS La relación riesgo-beneficio debe ser considerada cuando existan las siguientes situaciones clínicas: Deterioro severo de la función renal: La eliminación de claritromicina está reducida en pacientes con deterioro de la función renal; especialmente aquellos con una depuración de creatinina menor a 30 mL/min; puede ser necesario un ajuste en la dosis en pacientes con una depuración de creatinina menor de 30 mL/min. Deterioro de la función hepática: Se altera la farmacocinética de la claritromicina, disminuyendo la cantidad de metabolitos formados e incrementando la eliminación renal de la droga origen. Sin embargo, en condiciones de concentraciones uniformes en pacientes con deterioro leve a severo de la función hepática no difieren de los pacientes con una función hepática normal, a menos que hubiere también concomitante deterioro severo de la función renal. Este medicamento no debe estar al alcance de los niños.

DOSIS Y VÍA DE ADMINISTRACIÓN Vía de administración: Oral. Tabletas y polvo para suspensión oral • Dosis usual para adultos y adolescentes Antibacteriano: – Bronquitis, exacerbaciones bacterianas de la misma por H. influenzae: Oral, 500 mg, cada 12 horas durante 7 a 14 días. – Bronquitis, exacerbaciones bacterianas de la misma por otros organismos: Oral, 250 mg, cada 12 horas durante 7 a 14 días. – Faringitis estreptocócica: Oral, 250 mg, cada 12 horas durante 10 días. – Neumonía producida por S. pneumoniae o M. pneumoniae . Oral, 250 mg, cada 12 horas durante 7 a 14 días. – Sinusitis maxilar aguda: Oral, 500 mg, cada 12 horas durante 14 días. – Infecciones de piel y tejidos blandos: Oral, 250 mg, cada 12 horas durante 7 a 14 días. Nota: Estas dosis de claritromicina deberían ser ajustadas en pacientes con deterioro severo de la función renal (depuración de creatinina [CrCl] <30 mL/min). Las siguientes pautas de dosaje son sugeridas:

Dosis por CrCl de >30 mL/min (0,50 mL/sec)

Ajuste de dosis por CrCl de <30 mL/min (0,50 mL/sec)



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Mirtazapine Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Mirtabene

mirtazapine

GENERIC NAME(S): MIRTAZAPINE

Warnings

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression. other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition.

Tell the doctor right away if you notice worsening depression /other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety. panic attacks. trouble sleeping. irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.

Uses

Mirtazapine is used to treat depression. It improves mood and feelings of well-being. Mirtazapine is an antidepressant that works by restoring the balance of natural chemicals (neurotransmitters) in the brain .

How to use mirtazapine

Read the Medication Guide provided by your pharmacist before you start using mirtazapine and each time you get a refill because new information may be available. If you have any questions regarding the information, consult your doctor or pharmacist.

Take this medication by mouth. with or without food, usually once daily at bedtime or as directed by your doctor. The dosage is based on your medical condition and response to therapy, but should not exceed 45 milligrams per day.

Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day. It may take between 1-4 weeks to notice improvement in your symptoms. Therefore, do not increase your dose or take it more often than prescribed.

It is important to continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is abruptly stopped. Your dose may need to be gradually decreased.

Inform your doctor if your condition persists or worsens.

Side Effects

See also the Warning section.

Dizziness. drowsiness, lightheadedness, increased appetite, weight gain, dry mouth. or constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To relieve dry mouth. suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water or use a saliva substitute.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: swelling of the hands/feet, shaking (tremor), confusion, signs of infection (e. g. fever, persistent sore throat ).

Get medical help right away if you have any very serious side effects, including: fast/irregular heartbeat. severe dizziness, fainting. eye pain /swelling/redness, vision changes (such as seeing rainbows around lights at night, blurred vision ).

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome /toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations. loss of coordination, severe dizziness, severe nausea /vomiting /diarrhea. twitching muscles, unexplained fever. unusual agitation/restlessness.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to it, or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history or family history of psychiatric disorders (e. g. bipolar/manic-depressive disorder), history or family history of suicide attempts, liver disease, kidney disease. seizures, high blood cholesterol or triglyceride levels. heart disease (e. g. recent heart attack. angina), stroke, severe loss of body fluids (dehydration), low blood pressure. personal or family history of glaucoma (angle-closure type).

Mirtazapine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using mirtazapine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using mirtazapine safely.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness and QT prolongation (see above).

This medication should be used only when clearly needed during pregnancy. If this medication is used during the last 3 months of pregnancy, infrequently your newborn may develop symptoms including feeding or breathing difficulties, seizures, muscle stiffness, jitteriness or constant crying. Report any such symptoms to your doctor promptly. However, since untreated mental/mood disorders (such as depression) can be a serious condition, do not stop taking this medication unless your doctor directs you to do so. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication.

The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), tryptophan, among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), and narcotic pain relievers (such as codeine, hydrocodone ).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: very fast/irregular heartbeat, severe dizziness, fainting.

Notes

Psychiatric/medical checkups (and possibly laboratory tests) must be done periodically to monitor your progress and check for side effects. Consult your doctor for more details.

Do not share this medication with others.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Description

Allopurinol (brand names include: Zyloprim / Allohexal / Allosig / Progout / Zyloric / Puricos) belongs to a group of medicines called anti-uricaemics.

These medicines work by reducing the formation and accumulation of uric acid in the body. Excess amounts of uric acid in the blood may lead to the development of crystals which deposit in the joints, causing pain, swelling and tenderness.

Allopurinol is used in the treatment of:

gout or gouty arthritis (a condition of painful swollen joints caused by uric acid crystals); kidney stones (uric acid crystals in the kidney); skin tophi (uric acid crystals beneath the skin); other rare conditions where high levels of uric acid occur in the blood (eg. Lesch-Nyhan syndrome).

Your doctor may have prescribed Allopurinol for another reason.

Full product description

Recommendations

Follow the directions for using this medicine provided by your doctor. Take Allopurinol exactly as directed.

The dose varies from person to person. Your doctor will tell you how many tablets you need to take each day.

In adults, the usual dose is 100 mg to 200 mg daily for mild conditions, 300 mg to 600 mg daily for moderately severe conditions and 700 mg to 900 mg daily for severe conditions.

Elderly people over 65 years of age and those with kidney or liver problems may need smaller doses.

For children under 15 years of age the dose is calculated according to body weight. The maximum dose used in children is usually 400 mg daily.

Your doctor may advise you to take a different dose. This depends on your condition and whether or not you are taking any other medicines.

Swallow the tablets with a glass of water. It is important to drink at least 2 litres of fluid each day when you have high levels of uric acid in the blood.

Take Allopurinol during or immediately after a meal.

Allopurinol is usually taken once a day. However, if your dose is higher than 300 mg a day, your doctor may advise you to take it morning and night.

Precautions

Tell your doctor before taking Allopurinol, if:

you are allergic to any medicines; you or a member of your immediate family have haemochromatosis; you are having an acute attack of gout; you are pregnant or breast-feeding.

Ingredients

Active ingredient: allopurinol.

Testimonials

Allopurinol was very very effective for me. Gout attacks made me nearly powerless but this medication changed things for the better. It noticed only one side effect, it was excessive sweating. Just a couple of quick steps can make me all wet. It is not very pleasant but it is definitely less confusing than having a gout attack.

I first started having attacks of gout when I was 31. My doctor failed to diagnose me in the right way, so in a couple of month I addressed a rheumatologist, who prescribed me with Allopurinol. The worst thing is that I've heard people who take these pills can no longer deal without them. But having to choose between gout and pills till the end of the life, I chose Allopurinol

For me Allopurinol is a lifesaver! I have been using the pills for about the past 15 years. I am now 76. Since I remember myself I've been leading an active way of life, I do exercises and go in for sports. With such lifestyle gout attacks make my life stop. That's why allopurinol pills naturally bring me back alive and I have never had any side effects from them.

M. J. Nilsson, Mass

About 12 years ago my doctor found out that the level of uric acid in my blood was above normal. Soon afterwards I started having gout attacks and felt myself an old helpless ass. But my doc, a nice young lady, prescribed me with Allopurinol. It has been 10 years since I started taking the pills and I'm still damn grateful to my wonderful doctor!

Zackary Reed, NY

I know what Allopurinol is, I use it for 5 years now. What I have to say is that Allopurinol is only effective after regular use for a few months. It can not cure your gout or stop an attack that has already started. But it brings you back the control over your life. For me it is exactly what I need.

Mary Jane Lopez, Texas

I am not an old crack but from time to time I suffer from attacks of gout. When it makes me feel really miserable I take allopurinol, but I do not observe any regimen. May be if I would, the attacks would step away. I'll try it next month!

Milton Brown, Canada

Guys, avoid making the same mistakes as I do. Take your allopurinol regularly if you want to keep away from gout attacks. If you happen to miss a dose of this medicine, take it as soon as you remember. If I understand it right, regular doses of the med help your body maintain the normal level of uric acid in your blood.



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COMPOSICIÓN Cada mL contiene: Diclofenaco potásico 15 mg (Como diclofenaco resinato extrafino) Excipientes c. s.p 1 mL

ACCIÓN FARMACOLÓGICA: DOLO LIVIOLEX® 1,5% gotas contiene diclofenaco resinato, una sustancia no esteroide con acusadas propiedades analgésicas, antiinflamatorias y antipiréticas. Se considera importante para su mecanismo de acción la inhibición de la biosíntesis de las prostaglandinas, según se ha demostrado de forma experimental. Las prostaglandinas desempeñan un papel primordial en la aparición de la inflamación, el dolor y la fiebre. In vitro, el diclofenaco no suprime la biosíntesis de proteoglicanos en el cartílago a concentraciones equivalentes a las alcanzadas en seres humanos. Se ha demostrado que DOLO LIVIOLEX® 1,5% Suspensión - gotas ejerce un acusado efecto analgésico en los casos de dolor de moderado a severo. Asimismo, en los casos de inflamación, p. ej. traumática u otra como una intervención quirúrgica, alivia rápidamente el dolor espontaneo, el dolor al hacer movimientos y reduce la tumefacción inflamatoria y el edema traumático. Absorción: El diclofenaco contenido en la suspensión del resinato se absorbe completamente. La absorción se instaura inmediatamente después de la administración. Tras la administración de una cantidad de gotas equivalente a 50 mg de diclofenaco potásico, se obtiene un pico de las concentraciones en plasma de unos 0,9 mcg/mL (2,75 mcg/mol/l) en un intervalo de una hora. La cantidad absorbida es directamente proporcional al volumen de la dosis. Dado que aproximadamente la mitad del diclofenaco se metaboliza durante su primer paso a través del hígado (efecto de “primer paso”), el área bajo la curva de concentración (ABC) tras la administración oral o rectal es aproximadamente la mitad de la obtenida tras una dosis parenteral equivalente. El comportamiento farmacocinético no varia tras la administración repetida. No se produce acumulación si se respetan los intervalos recomendados entre las dosis. Distribución: El diclofenaco se fija en un 99,7% a las proteínas sericas, sobre todo a la albúmina (99,4%).El volumen aparente de distribución calculado es de 0,12-0,17 l/kg. El diclofenaco pasa al líquido sinovial, donde las concentraciones máximas se miden en un intervalo de 2 a 4 horas después de haber alcanzado el pico de los valores en plasma. La vida media aparente de eliminación en el liquido sinovial es de 3 a 6 horas. Dos horas después de haber alcanzado el pico de los niveles en plasma, las concentraciones de la sustancia activa son ya más altas en el liquido sinovial que en el plasma permaneciendo mayores durante un intervalo de hasta 12 horas. Biotransformación: La biotransformación del diclofenaco se efectúa por glucurodinación de la molécula intacta, pero ante todo por hidroxilación simple y múltiple y metoxilación que producen varios metabolitos fenólicos (3-hidroxi-,4-hidroxi-,5-hidroxi-,4-5 dihidroxi - y 3´-hidroxi-4´-hidroxi-,5´-hidroxi-,4´-5-dihidroxi– y 3´ - hidroxi-4´-metoxi-diclofenaco), la mayoria convertidos en conjugados glucorónidos. Dos de estos metabolitos fenólicos son biológicamente activos, aunque en mucho menor grado que el diclofenaco. Eliminación: El aclaramiento sistémico total del diclofenaco en plasma es de 263 ± 56 mL/min (valor medio ± DT). La vida media terminal en plasma es de 1 a 2 horas. Cuatro de los metabolitos, inclusive los dos activos, tienen también vidas medias cortas en plasma de una a tres horas. Un metabolito, el 3’hidroxi-4 metoxi-diclofenaco, tiene una vida media en plasma mucho mayor. Sin embargo, este metabolito es virtualmente inactivo. Alrededor del 60% de la dosis administrada se excreta con la orina en forma de conjugado glucurónido de la molécula intacta y como metabolitos convertidos también en su mayor parte en conjugados glucurónidos. Menos del 1% se excreta como sustancia inalterada. El resto de la dosis se elimina como metabolitos por la bilis en las heces. Características de los pacientes: No se han registrado diferencias relevantes en la absorción, el metabolismo y la excreción del fármaco debidas a la edad del paciente. Con la aplicación del esquema posológico normal en pacientes con la función renal limitada no se ha podido observar una acumulación de la sustancia activa inalterada a partir de la cinética de la dosis única. Dado un aclaramiento de creatinina menor a 10 ml/min, los niveles en plasma de los hidroximetabolitos en el estado estacionario son unas cuatro veces mayor que en los sujetos sanos. No obstante, los metabolitos se excretan finalmente por la bilis. La cinética y el metabolismo del diclofenaco en pacientes con hepatitis crónica o cirrosis sin descompensación discurren igual que en los pacientes con hígado sano.

INDICACIONES Tratamiento breve de las afecciones agudas citadas a continuación: Dolor postraumático y posoperatorio, inflamación y tumefacción, p. ej. tras una intervención quirúrgica dental u ortopédica. Como coadyugante en las infecciones inflamatorias dolorosas graves del oído, nariz o garganta, p. ej. faringoamigdalitis, otitis. Con el fin de seguir los principios terapéuticos generales, la afección subyacente se tratará con una terapia básica. La fiebre no es considerada una indicación.

INTERACCIONES MEDICAMENTOSAS Litio, digoxina: DOLO LIVIOLEX® 1,5% Suspensión-gotas puede provocar un aumento de las concentraciones en plasma de litio y digoxina. Diuréticos: Como otros AINE DOLO LIVIOLEX® 1,5% Suspensión-gotas puede inhibir la actividad de los diuréticos, el tratamiento concomitante con diuréticos que ahorren potasio puede estar relacionado con un aumento de los niveles de potasio en suero haciendo, pues, necesario su control periódico. Anticoagulantes: Aunque los estudios clínicos parecen indicar que el DOLO LIVIOLEX® 1,5% Suspensión-gotas no influye sobre la acción de los anticoagulantes, existen informes aislados sobre un mayor riesgo de hemorragia en los pacientes sometidos a un tratamiento concomitante con DOLO LIVIOLEX® 1,5% Suspensión-gotas y anticoagulantes. Por lo tanto se recomienda vigilar estrechamente a tales pacientes. Antidiabéticos: Los estudios clínicos han mostrado que DOLO LIVIOLEX® 1,5% gotas puede administrarse junto con antidiabéticos orales sin que influya sobre su efecto clínico. No obstante, existen informes aislados sobre la aparición de efectos tanto hipoglicémicos como hiperglicémicos durante el tratamiento con DOLO LIVIOLEX® 1,5% Suspensión-gotas, que exigen modificar la dosificación del hipoglicemiante. Metotrexato: Se recomienda tener precaución cuando se empleen los AINE menos de 24 horas antes o después de un tratamiento con metotrexato, ya que pueden elevar las concentraciones en sangre del metotrexato y aumentar la toxicidad del mismo. Ciclosporina: La nefrotoxicidad de la ciclosporina puede aumentar debido a los efectos de los AINE sobre las prostaglandinas renales. Quinolonas antibacterianas: Existen informes aislados sobre convulsiones debidas posiblemente al empleo concomitante de quinolonas y AINE.

CONTRAINDICACIONES: Úlcera gástrica o intestinal. Hipersensibilidad conocida a la sustancia activa o a los excipientes. Al igual que otros fármacos antiinflamatorios no esteroides (AINE), DOLO LIVIOLEX® 1,5% gotas está también contraindicado en pacientes que sufren ataques de asma, urticaria o rinitis aguda tras la administración de ácido acetilsalicílico u otros fármacos inhibidores de la actividad de las prostaglandinas sintetasa.

PRECAUCIONES: Es imprescindible una estricta vigilancia médica de los pacientes con síntomas indicadores de transtornos gastrointestinales o con historial que sugiere la presencia de úlcera gástrica o intestinal, pacientes con colitis ulcerosa o enfermedad de Crohn, así como en pacientes con menoscabo de la función hepática. Como ocurre con otros AINE pueden aumentar los valores de una o varias enzimas hepáticas. A titulo preventivo se recomienda el control de la función hepática durante el tratamiento prolongado con el DOLO LIVIOLEX® 1,5% Suspensión-gotas. No obstante deberá de tenerse en cuenta que solo se recomienda el tratamiento breve con DOLO LIVIOLEX® 1,5% Suspensión-gotas. Si las pruebas de la función hepática siguen mostrando resultados anormales o empeoran, si aparecen síntomas o signos clínicos típicos del inicio de una enfermedad hepática o si se muestran otros fenómenos (p. ej. eosinofilia, exantema, etc.) se interrumpirá la medicación con el DOLO LIVIOLEX® 1,5% Suspensión gotas. La hepatitis puede sobrevenir sin síntomas prodrómicos. Se tendrá precaución al administrar DOLO LIVIOLEX® 1,5% Suspensión-gotas en pacientes con porfiria hepática, ya que DOLO LIVIOLEX® 1,5% Suspensión-gotas puede precipitar un ataque. Dada la importancia de las prostaglandinas en el mantenimiento de la irrigación renal, se tendrá especial cuidado en los pacientes con menoscabo de la función renal o cardiaca, las personas de edad avanzada, los pacientes tratados con diuréticos y aquellos con una depleción sustancial del volumen extracelular por alguna causa p. ej. antes o después de una intervención quirúrgica mayor. A título preventivo, se recomienda el control de la función renal durante la administración de DOLO LIVIOLEX® 1,5% Suspensión-gotas en tales casos a la interrupción del tratamiento suele seguir la recuperación hasta el estado anterior a la terapéutica. La duración del tratamiento con DOLO LIVIOLEX® 1,5% Suspensión-gotas en las indicaciones mencionadas anteriormente suele ser tan solo de varios días. No está recomendado el uso de DOLO LIVIOLEX® 1,5% Suspensión - gotas en forma prolongada por el riesgo de producir frenación medular. No obstante y al igual que con otros AINE en los caos que sea necesario administrar DOLO LIVIOLEX® 1,5% Suspensión-gotas durante un tiempo mayor al recomendado, es decir, si se administra durante un periodo más prolongado, se recomienda la realización de hemacitometrías. Al igual que con otros AINE, DOLO LIVIOLEX® 1,5% Suspensión-gotas puede inhibir temporalmente la agregación plaquetaria. Los pacientes con transtorno de hemostasis deberán ser controlados cuidadosamente. Por razones médicas de índole básicas, se recomienda especial precaución en los pacientes de edad avanzada. En particular, se recomienda emplear la dosis eficaz mínima en los pacientes ancianos débiles o en los que tengan poco peso corporal. Embarazo y lactancia • Embarazo: DOLO LIVIOLEX® 1,5% Suspensión-gotas solo se administrará durante el embarazo en casos extremos y utilizando únicamente la dosis eficaz mínima. Al igual que en los casos de los otros inhibidores de las prostanglandinas-sintetasa, lo presente rige sobre todo durante los tres últimos meses de gestación (debido a la posibilidad que se produzca inercia uterina y/o un cierre prematuro del ductus arteriosus ). • Lactancia: Tras la administración cada 8 horas de la dosis oral de 50 mg, la sustancia activa pasa a la leche materna, aunque en cantidades tan ínfimas que normalmente no se producen efectos no deseados en los niños. Efectos sobre la capacidad para conducir vehículos y utilizar maquinaria: Los pacientes que experimenten mareos u otros trastornos del Sistema Nervioso Central, inclusive trastornos de la visión, no deberán conducir vehículos ni manejar maquinaria.

INCOMPATIBILIDADES Ninguna conocida hasta la fecha.

REACCIONES ADVERSAS Tracto gastrointestinal • Ocasionales: Dolor epigástrico y otros trastornos gastrointestinales como náusea, vómito, diarrea, calambres abdominales, dispepsias, flatulencias, anorexia. • Raros: Hemorragia gastrointestinal (hematemesis, melena, diarrea sanguinolenta), úlcera gástrica o intestinal con o sin hemorragia o perforación. • Casos aislados: Estomatitis aftosa, glositis, lesiones esofágicas, estenosis intestinal por formación de “diafragmas”, trastornos intestinales bajos como colitis hemorrágica no especifica y exacerbación de la colitis ulcerosa o enfermedad de Crohn, estreñimiento, pancreatitis. Sistema Nervioso Central: • Ocasionales: Cefaleas, mareos, vértigo. • Raros: Somnolencia. • Casos aislados: Trastornos de la sensibilidad, inclusive perestesias, trastornos de la memoria, desorientación, insomnio, inestabilidad, convulsiones, depresión, ansiedad, pesadillas, temblor, reacciones psicóticas, meningitis aséptica. Sentidos especiales • Casos aislados: Trastornos de la visión (visión borrosa, diplopia), pérdida del oido, tinnitus, alteraciones del gusto. Piel • Ocasionales: Exantemas o erupciones cutáneas. • Raros: Urticaria. Casos aislados: erupciones bulosas, eccema, eritema multiforme, sindrome de Stevens-Johnson, síndrome de Lyell (epidemólisis tóxica aguda), eritrodermia (dermatitis exfoliativa), caída del cabello, reacciones de fotosensibilidad, púrpura, inclusive púrpura alérgica. Riñones • Raros: Edema. • Casos aislados: insuficiencia renal aguda, alteraciones urinarias como hematuria y proteinuria, nefritis intersticial, síndrome nefrótico, necrosis papilar. Hígado • Ocasionales: Incremento de los valores de las aminotransferasas en suero. • Raros: Hepatitis con o sin ictericia. • Casos aislados: hepatitis fulminante. Sangre • Casos aislados: Trombocitopenia, leucopenia, anemia hemolítica, anemia aplasica, agranulocitosis. Hipersensibilidad • Raros: Reacciones de hipersensibilidad tales como asma, reacciones sistémicas anaflácticas–anafilactoides inclusive hipotensión. • Casos aislados: Vasculitis. pneumonitis. Sistema cardiovascular • Casos aislados: Palpitaciones, dolor torácico, hipertensión, insuficiencia cardiaca congestiva.

ADVERTENCIAS: Por falta de experiencia en el uso en niños menores de 1 año, se recomienda administrar solo en mayores de dicha edad. En cualquier momento durante el tratamiento puede producirse hemorragia gastrointestinal o úlcera/perforación con o sin síntomas prodrómicos o historial previo. Generalmente las consecuencias son más graves en los pacientes de edad avanzada. DOLO LIVIOLEX® 1,5% Suspensión-gotas se retirará en aquellos casos excepcionales en los que se produzca hemorragia gastrointestinal o úlcera. Como sucede con otros AINE, en raras ocasiones pueden producirse reacciones alérgicas, inclusive anafilácticas anafilactoides, sin exposición previa al fármaco. Al igual que otro AINEs, DOLO LIVIOLEX® 1,5% Suspensión - gotas puede enmascarar los signos y síntomas de la infección debido a sus propiedades farmacodinámicas.

DOSIS Y VÍA DE ADMINISTRACIÓN: DOLO LIVIOLEX® 1,5% Suspensión - gotas está especialmente indicado para su empleo en pediatría, dado que es posible adaptar la dosis de forma individual según el peso corporal de cada niño y de acuerdo al esquema posológico recomendado para ellos (1 gota: 0,5 mg). Niños: En niños a partir de un año de edad se administrarán de 0,5 mg a 2 mg/kg de peso corporal al día, según la gravedad que revista la afección. La dosis diaria se dividirá normalmente en 2 ó 3 tomas separadas. Nota: Agitar el frasco que contiene la suspensión antes de administrar las gotas.

TRATAMIENTO EN CASO DE SOBREDOSIS: El tratamiento de la intoxicación aguda por AINEs consiste principalmente en medidas de apoyo y sintomáticas. No se conoce un cuadro clínico típico asociado con la sobredosificación con diclofenaco. Las medidas terapéuticas a tomar en caso de sobredosificación son las siguientes: Prescripción de un tratamiento de apoyo y sintomático contra complicaciones tales como hipotensión, insuficiencia renal, convulsiones, irritación gastrointestinal y depresión respiratoria. Los tratamientos específicos como diúresis forzada, diálisis o hemoperfusión son probablemente poco útiles para acelerar la eliminación de los AINEs a causa de su elevada tasa de fijación proteica y su metabolismo extenso.

PRESENTACIÓN DOLO LIVIOLEX® Gotas orales: Caja x 1 frasco x 20 mL.

MAGMA Una División de: CORPORACIÓN INFARMASA S. A. Av. Juan Pablo Fernandini 1140, Pueblo Libre Telfs. 424-0333, 424-0314 Lima-Perú



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Acidrine In The Management Of Gastritis And Duodenitis, Acidrine

Acidrine in the management of gastritis and duodenitis. A double-blind placebo controlled clinical trial

[Show abstract] [Hide abstract] ABSTRACT: A double-blind, placebo-controlled study was carried out in 40 out-patients with endoscopically confirmed hypertrophic or erosive gastritis, without ulcer, to assess the effectiveness and tolerance of treatment with equine antisera (antidiencephalon and anti-stomach tissue). Patients were assigned at random to receive a single dose in suppository form on 2 days a week for 6 weeks of both antisera (anti-diencephalon on Days 1 and 4, anti-stomach tissue on Days 2 and 5) or placebo (saline solution). No other anti-ulcer treatment was allowed except standard antacid tablets, the consumption of which was recorded and used as an evaluation parameter. Endoscopy, haematology and haematochemistry were performed before and after treatment; symptoms (daytime and night-time pain, heartburn and dyspepsia) and possible adverse reactions were scored 0 to 4 in order of increasing severity before treatment and after 1, 2, 4 and 6 weeks. Five patients in the placebo group had to be withdrawn from the trial at the second week because of therapeutic failure. This proportion was significantly in favour of the antisera group, as was the proportion of patients endoscopically healed and the extent and rate of symptomatic improvement. Concomitant antacid consumption rapidly and significantly decreased in the antisera but not in the placebo group. Signs of intolerance were not observed with either treatment, nor were there any significant alterations in haematology or haematochemistry. In particular, the immune titre of patients did not increase after treatment, thus indicating that the administered heterologous proteins did not elicit an immunization of the patients against horse protein.(ABSTRACT TRUNCATED AT 250 WORDS)

Full-text · Article · Feb 1985



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Lactulose Medlineplus Drug Information, Lactulos

Lactulose

Lactulose is a synthetic sugar used to treat constipation. It is broken down in the colon into products that pull water out from the body and into the colon. This water softens stools. Lactulose is also used to reduce the amount of ammonia in the blood of patients with liver disease. It works by drawing ammonia from the blood into the colon where it is removed from the body.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Lactulose comes as liquid to take by mouth. It usually is taken once a day for treatment of constipation and three or four times a day for liver disease. Your prescription label tells you how much medicine to take at each dose. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lactulose exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

What special precautions should I follow?

Before taking lactulose,

tell your doctor and pharmacist if you are allergic to lactulose or any other drugs.

tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antacids, antibiotics including neomycin (Mycifradin), and other laxatives.

tell your doctor if you have diabetes or require a low-lactose diet.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking lactulose, call your doctor.

if you are having surgery or tests on your colon or rectum, tell the doctor that you are taking lactulose.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Lactulose may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

If you have any of the following symptoms, stop taking lactulose and call your doctor immediately:

stomach pain or cramps

vomiting

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What other information should I know?

Keep all appointments with your doctor.

To improve the taste of lactulose, mix your dose with one-half glass of water, milk, or fruit juice.

Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

¶ This branded product is no longer on the market. Generic alternatives may be available.

Last Reviewed - 09/01/2010

American Society of Health-System Pharmacists, Inc. Disclaimer

AHFS ® Patient Medication Information. © Copyright, 2016. The American Society of Health-System Pharmacists, Inc. 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.



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Ethionamide Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Aethionamidum

ethionamide

Uses

Ethionamide is used with other medications to treat tuberculosis (TB). Ethionamide is an antibiotic and works by stopping the growth of bacteria.

This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold. flu ). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This drug may also be used with other medications to help treat a certain serious infection (Mycobacterium avium complex-MAC).

How to use ethionamide

Take this medication by mouth with or without food, usually once daily or as directed by your doctor. If this medication causes stomach upset or nausea /vomiting. take this medication with meals. Also, discuss with your doctor if it may be helpful to divide your daily dose into smaller doses to be taken several times a day. Follow your doctor's instructions carefully.

The dosage is based on your age, weight. medical condition, and response to treatment.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. To help you remember, take it at the same time(s) each day.

Continue to take this medication (and other TB medications) until the full prescribed amount is finished, even if symptoms disappear. Stopping the medication too early or skipping doses may allow the bacteria to continue to grow, which may result in a return of the infection and cause the infection to be more difficult to treat (resistant).

Your doctor may also direct you to take vitamin B6 (pyridoxine) to help prevent certain side effects (such as nerve problems) from ethionamide. Follow your doctor's instructions carefully.

Tell your doctor if your condition persists or worsens.

Side Effects

Nausea, vomiting, diarrhea. abdominal/stomach pain. increased saliva. strange metallic taste in the mouth. loss of appetite, or sores in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication may develop serious side effects, but with frequent visits to your doctor, this risk can be minimized.

Tell your doctor right away if any of these unlikely but serious side effects occur: unusual hunger. unusual sweating. shakiness, persistent nausea/vomiting, unusual tiredness/weakness. yellowing eyes /skin. dark urine, joint pain /swelling, slow heartbeat, mental/mood changes (such as nervousness, restlessness, depression ).

Tell your doctor right away if any of these rare but serious side effects occur: vision changes (such as blurred/decreased/double vision. color blindness ), eye pain. numbness/tingling of arms/legs.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking ethionamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Alcohol may increase the risk of liver disease or mental/mood changes. Avoid alcoholic beverages while using this medication.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

If you have diabetes, this product may make it harder to control your blood sugar levels (cause low blood sugar). Check your blood sugar levels regularly as directed by your doctor. Tell your doctor right away if you have symptoms of low blood sugar, such as shakiness, unusual hunger, or unusual sweating. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Keep a list of all the products you use. Share the list with your doctor and pharmacist to reduce your risk for serious medication problems.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as sputum test, eye/vision exams, liver/thyroid function, blood glucose, complete blood count) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to take each scheduled dose of this medication as directed. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Clindamycin (Cleocin T, Clinda-Derm) Side Effects & Uses, Clidacin-T

clindamycin, Cleocin T, Clinda-Derm

BRAND NAME: Cleocin T, Clindagel, ClindaDerm, Clindets, Evoclin

GENERIC AVAILABLE: Yes

PRESCRIBED FOR: Clindamycin topical (for application to the skin) is available as gels, foam, lotion, solution, and swab for treating acne.

SIDE EFFECTS: The most common side effects of topical clindamycin are:

Some clindamycin topical solutions contain an alcohol base which will cause burning and irritation in the eye.

Possible serious side effects of clindamycin include:

Stomach pain and folliculitis (inflammation of the tissue surrounding the base of hairs) may occur during treatment with topical clindamycin.

Orally administered and injected clindamycin may cause severe colitis. Topical formulations of clindamycin may be absorbed from the skin surface, and diarrhea. bloody diarrhea. and colitis (including pseudomembranous colitis) have been reported with the use of topical clindamycin.

PREPARATIONS: Gel, foam, lotion, solution, swab: 1%

DRUG INTERACTIONS: Clindamycin given orally may act as a neuromuscular blocker. This means it can increase the action of neuromuscular blocking drugs (for example, pancuronium and vecuronium) that block the contraction of muscles. Less clindamycin is absorbed into the blood stream when given topically so the likelihood of this drug interaction is less likely.

PREGNANCY AND BREASTFEEDING SAFETY: The frequency of congenital abnormalities was not increased when pregnant women used clindamycin during the second and third trimesters. Clindamycin has not been properly evaluated during the first trimester of pregnancy. It should only be used during the first trimester of pregnancy if it is clearly needed. Oral clindamycin is excreted in breast milk and either should not be used by nursing mothers or nursing should be stopped. It is not known whether clindamycin given topically is excreted in breast milk.

Medically Reviewed by a Doctor on 2/13/2016

Quick Guide Adult Acne (Pimples) Causes, Solutions and Treatments

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.



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Ciplox (Ciprofur)

Ciplox is used to treat different types of bacterial infections. It may also be used to prevent or slow anthrax after exposure.

Take Cipro exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take Cipro with a full glass of water (8 ounces). Drink several extra glasses of fluid each day while you are taking this medicine. Cipro may be taken with or without food, but take it at the same time each day. Shake the oral suspension (liquid) for at least 15 seconds just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

When taking the Cipro oral liquid, swallow it without chewing the medicine beads you may notice in the liquid.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time. Do not take Cipro with dairy products such as milk or yogurt, or with calcium-fortified juice. You may eat or drink these products as part of a regular meal, but do not use them alone when taking Cipro. They could make the medication less effective.

Take Cipro for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cipro will not treat a viral infection such as the common cold or flu.

Store Cipro at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

If you missed a dose - take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Take exactly as prescribed by your Health Provider.

Store this medicine at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

You should not use Ciplox if you are taking tizanidine (Zanaflex), if you have a history of myasthenia gravis, or if you are allergic to ciprofloxacin or similar antibiotics such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), and others.

Before taking Ciplox, tell your doctor if you have a heart rhythm disorder, kidney or liver disease, joint problems, diabetes, muscle weakness or trouble breathing, a condition called pseudotumor cerebri, a history of seizures, a history of head injury or brain tumor, low levels of potassium in your blood, a personal or family history of Long QT syndrome, or if you have ever had an allergic reaction to an antibiotic.

Do not take Ciplox with dairy products such as milk or yogurt, or with calcium-fortified juice. Avoid taking antacids, vitamin or mineral supplements, sucralfate (Carafate), or didanosine (Videx) powder or chewable tablets within 6 hours before or 2 hours after you take Ciplox. Ciprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. Stop taking Ciplox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions.

You should NOT take Ciplox if:

you are also taking tizanidine (Zanaflex);

you have a history of myasthenia gravis; or

you are allergic to ciprofloxacin or similar medications such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), ofloxacin (Floxin), norfloxacin (Noroxin), and others.

To make sure you can safely take Ciplox, tell your doctor if you have any of these other conditions:

heart rhythm disorder, especially if you take quinidine (Quin-G), disopyramide (Norpace), bretylium (Bretylol), procainamide (Pronestyl, Procan SR), amiodarone (Cordarone, Pacerone), or sotalol (Betapace);

a history of head injury or brain tumor;

a condition called pseudotumor cerebri (high pressure inside the skull that may cause headaches, vision loss, or other symptoms);

a history of allergic reaction to an antibiotic;

joint problems;

kidney or liver disease;

epilepsy or seizures;

diabetes;

muscle weakness or trouble breathing;

low levels of potassium in your blood (hypokalemia); or

a personal or family history of Long QT syndrome.

FDA pregnancy category C. It is not known whether Ciplox will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using it. Ciprofloxacin passes into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Ciplox may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking Ciplox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions. Do not share Ciplox with another person (especially a child), even if they have the same symptoms you have.

Get emergency medical help if you have any of these signs of an allergic reaction to Ciplox: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Ciplox and call your doctor at once if you have a serious side effect such as:

severe dizziness, fainting, fast or pounding heartbeats;

sudden pain, snapping or popping sound, bruising, swelling, tenderness, stiffness, or loss of movement in any of your joints;

diarrhea that is watery or bloody;

confusion, hallucinations, depression, unusual thoughts or behavior;

seizure (convulsions);

severe headache, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;

pale or yellowed skin, dark colored urine, fever, weakness;

urinating less than usual or not at all;

easy bruising or bleeding;

numbness, tingling, or unusual pain anywhere in your body;

the first sign of any skin rash, no matter how mild; or

severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects:

nausea, vomiting;

dizziness or drowsiness;

blurred vision;

feeling nervous, anxious, or agitated; or

sleep problems (insomnia or nightmares).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

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