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Buconif werken door middel van kalmerende bloedbaan (bijvoorbeeld omdat bloedvaten evenals slagaders), dat maakt het eenvoudiger voor uw cardiovasculaire om evenals functioneren vermindert de werklast.

Buconif kan ook worden aangeduid als Nifedipine, Nicardia, Nifedical, Procardia.

General titel geassocieerd met Buconif is eigenlijk Nifedipine.

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Veel minder typische en ernstige nadelige gevolgen voor de hele behulp Buconif: allergische reactie reacties (urticaria, en uitademen problemen, allergie alsmede uitbarsting)

Negatieve effecten indicaties zijn afhankelijk medicijnen gebruikt u mogelijk maar bovendien vertrouwen op je welzijn conditie en andere aspecten.

Buconif (Adalat) Contra-indicaties

Meestal niet Buconif te krijgen in het geval u gevoelig om elementen Buconif zijn.

Meestal niet krijgen Buconif als je anders je van plan bent om een ??kind te bezitten verwacht worden, anders wordt je echt een medische moeder. Buconif beschadigt uw kind.

Meestal heb Buconif niet te gebruiken in combinatie met natrium alternatieven of zelfs kalium voedingssupplementen.

Wilt u beste resultaten te bereiken met geen negatieve effecten is het raadzaam om alcoholische dranken te voorkomen.

Voorkom grapefruit vruchtensap tijdens de behandeling samen met Buconif.

Speel de rol van voorzichtige gebruik te maken van Buconif in het geval u worden getroffen door renale ziekte, ziekten in de lever, ziekten van het hart - of zelfs bloedbaan (zieke neus syndroom), aortastenose, cardiovasculair falen, lagere lage bloeddruk druk, of zelfs hart.

Meestal niet stoppen met het gebruik van Buconif ineens.

Buconif (Adalat) Veelgestelde vragen

Queen: Precies wat doet Buconif impliceren?

De: Buconif is echt een uitstekend geneesmiddel dat wordt verbruikt bij het verhelpen van een hoge bloeddruk of zelfs hypertensie, keelontstekingen of zelfs hart problems. A

Queen: Wat zijn precies merknaam als alsmede algemene merken geassocieerd met Buconif?

De: General titel geassocieerd met Buconif is eigenlijk Nifedipine. Merken geassocieerd met Buconif neiging om Buconif gesloten circuit, Procardia, Procardia XL. A

Queen: Wat is essentieel om te voorkomen dat precies?

De: Meestal heb Buconif niet te gebruiken in combinatie met natrium alternatieven of zelfs kalium voedingssupplementen. Wilt u het beste resultaat te bereiken, zonder negatieve effecten is het raadzaam om alcoholische dranken te voorkomen. Voorkomen grapefruit vruchtensap tijdens de behandeling samen met Buconif. A

Queen: Hoe kan echt Buconif lopen?

De: Buconif werkt door middel van kalmerende bloedbaan (bijvoorbeeld omdat bloedvaten evenals slagaders), dat maakt het eenvoudiger voor uw cardiovasculaire om evenals functioneren vermindert het werk load. A

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The Original Method for Atlas Realignment

The atlas is the first cervical vertebra, and along with the second vertebra, the axis forms the joint connecting the skull and the spine.

The atlas (C1) not only carries the skull, but is also responsible for the suspension, equilibrium and management of the spine and human skeleton.

AtlasPROfilax® is a neuromuscular massage technique that focuses on the short muscles of the neck - the suboccipital muscles - that surround and stabilize the head joints (base of the skull, atlas and axis vertebras).

Correction and Self Healing

Rene C. Schumperli developed a revolutionary method that successful aligns the atlas vertebra without cracking, rough handling or traction, in only one session. After the vibrational massage of the short muscles of the neck, the atlas can move in its natural position.

The release of muscular tension in the neck corrects ligamentous and muscular compression on the atlas vertebra, producing a positive effect on the body and stimulating the healing capacity.

AtlasPROfilax® is a safe, effective, one-time application and does not pose any health risk.

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Cyproheptadine - Side Effects, Dosage, Interactions, Pronicy

Cyproheptadine

Cyproheptadine is a prescription medication used to relieve allergy symptoms, itching, and to increase appetite.

Cyproheptadine belongs to group of drugs known as first-generation antihistamines.

It works by blocking the release of histamine, a chemical in the body that causes allergic responses such as a runny nose, watery eyes, sneezing, and itching.

Cyproheptadine was originally approved by the Food and Drug Administration (FDA) under the brand name Periactin in 1961 and was manufactured by Merck Pharmaceuticals.

Periactin is no longer on the market, and the only form currently available is generic cyproheptadine.

Cyproheptadine Warnings

You should not take cyproheptadine if:

You are allergic to cyproheptadine, any similar drugs, or any other ingredients found in the drug

You live in a place where the weather is very hot most of the time

You have a blockage in the opening of your bladder

You are breastfeeding

You have glaucoma (especially if it is angle-closure glaucoma)

You have ulcers

You are 65 years of age or older

It's not recommended that newborn babies, premature babies, or children under the age of 2 take cyproheptadine.

Also, cyproheptadine can cause some very dangerous side effects in people who are 65 years of age or older, like confusion, drowsiness, and dizziness, which can make them more susceptible to falls and other serious accidents.

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Pregnancy and Cyproheptadine

Cyproheptadine falls under the FDA's Pregnancy Category B, which means that harm to a developing fetus is unlikely.

Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

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It's always important to tell your doctor and pharmacist all of the medications you are taking.

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Klor-Con (potassium chloride)

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Some other medications that have serious interactions with cyproheptadine include:

Monoamine oxidase inhibitors (MAOIs) like Marplan (isocarboxazid), Nardil (phenelzine), and Matulane (procarbazine)

Symlin (pramlinitide)

Parkinson's disease medications like Azilect (rasagiline), Zelapar or Eldepryl (selegeline and selegeline transdermal), and tranylcypromine

Benzodiazepines like Xanax (alprazolam), Klonopin (clonazepam), and Ativan (lorazepam)

Opiates like Zohydro and Zotripro (hydrocodone), Dilaudid (hydromorphone), and Avinza, Astromorph, MS Contin, and Kadian (morphine)

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Cyproheptadine and Alcohol

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Cyproheptadine and Grapefruit Juice

Avoid eating grapefruit and drinking grapefruit juice while taking cyproheptadine.

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EMEP History and Structure

The Convention on Long-range Transboundary Air Pollution (LRTAP). signed in 1979, is one of the central means for protection of our environment. It establishes a broad framework for co-operative action on reducing the impact of air pollution and sets up a process for negotiating concrete measures to control emissions of air pollutants through legally binding protocols. In this process, the main objective of the EMEP programme (Co-operative Programme for Monitoring and Evaluation of the Long-range Transmission of Air Pollutants in Europe) is to regularly provide governments and subsidiary bodies under the LRTAP Convention with qualified scientific information to support the development and further evaluation of the international protocols on emission reductions negotiated within the Convention.

Initially, the EMEP programme focused on assessing the transboundary transport of acidification and eutrophication. Later, the scope of the programme has widened to address the formation of ground level ozone and, more recently, of persistent organic pollutants (POPs). heavy metals and particulate matter.

The EMEP programme relies on three main elements: (1) collection of emission data, (2) measurements of air and precipitation quality and (3) modelling of atmospheric transport and deposition of air pollutions. Through the combination of these three elements, EMEP fulfils its required assessment and regularly reports on emissions, concentrations and depositions of air pollutants, the quantity and significance of transboundary fluxes and related exceedances to critical loads and threshold levels. The combination of these components provides also a good basis for the evaluation and qualification of the EMEP estimates.

The EMEP programme is carried out in collaboration with a broad network of scientists and national experts that contribute to the systematic collection, analysis and reporting of emission data, measurement data and integrated assessment results. Four different Task Forces within EMEP provide a fora for discussion and scientific exchange. These are the following: the Task Force on Meaurements and Modelling (TFMM ), the Task Force on Emission Inventories and Projections (TFEIP ). the Task Force on Integrated Assessment Modellling (TFIAM ) and Task Force on Hemispheric Transport of Air Pollutants (TFHTAP).

The co-ordination and intercalibration of chemical air quality and precipitation measurements are carried out at the Chemical Coordinating Centre (CCC). The Meteorological Synthesizing Centre - West (MSC-W) is responsible for the modelling assessment of sulphur, nitrogen photooxidant pollutants and atmospheric particles. The modelling development for heavy metals and POPs is the responsibility of the Meteorological Synthesizing Centre - East (MSC-E). In 1999 the Executive Body of the Convention decided to include integrated assessment into the core activities of EMEP and to establish a Center for Integrated Assessment Modelling (CIAM) building on past modelling work, in particular the RAINS model. The EMEP Centre on Emission Inventories and Projections (CEIP) has the task to collect emissions and projections of acidifying air pollutants, heavy metals, particulate matter and photochemical oxidants.

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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Prospecto De Medicamentos Prareduct 20 Mg Comprimidos, 28 Comprimidos, Prareduct

PRAREDUCT® 20 mg comprimidos

2. COMPOSICION CUALITATIVA Y CUANTITATIVA

Cada comprimido contiene 20 mg de pravastatina sodica.

Lista de excipientes, ver apartado 6.1.

3. FORMA FARMACEUTICA

Comprimido ranurado, amarillo, biconvexo, oblongo y con el numero "20" grabado en una cara.

4. DATOS CLINICOS

4.1 Indicaciones terapeuticas

Hipercolesterolemia Tratamiento de la hipercolesterolemia primaria o dislipemia mixta, junto con la dieta, cuando la respuesta a la dieta y a otros tratamientos no farmacologicos (p. ej. ejercicio, reduccion de peso) es inadecuada.

Prevencion primaria Reduccion de la mortalidad y morbilidad cardiovascular en pacientes con hipercolesterolemia moderada o grave y con riesgo elevado de un primer episodio cardiovascular, como tratamiento adicional a la dieta (ver apartado 5.1).

Prevencion secundaria Reduccion de la mortalidad y la morbilidad cardiovascular en pacientes con antecedentes de infarto de miocardio o angina de pecho inestable y con niveles normales o elevados de colesterol, junto a la correccion de otros factores de riesgo (ver apartado 5.1).

Postrasplante Reduccion de la hiperlipidemia postrasplante en pacientes que reciben tratamiento inmunosupresor despues de trasplante de organos solidos. (ver apartados 4.2, 4.5 y 5.1).

4.2 Posologia y forma de administracion

Antes de iniciar el tratamiento con PRAREDUCT, deben descartarse causas secundarias de hipercolesterolemia y los pacientes deben someterse a una dieta estandar hipolipemiante, que debera mantenerse durante el tratamiento.

PRAREDUCT se administra por via oral una vez al dia, preferiblemente por la noche, sin tener en cuenta la ingesta de alimentos.

Hipercolesterolemia: El intervalo de dosis recomendado es de 10 mg a 40 mg una vez al dia. La respuesta terapeutica se evidencia en una semana y la respuesta maxima a una dosis determinada se alcanza transcurridas cuatro semanas, por lo que deben realizarse determinaciones periodicas de los lipidos y se debe ajustar la dosis en consecuencia. La dosis maxima es de 40 mg al dia.

Prevencion cardiovascular: En todos los estudios de morbi-mortalidad, la unica dosis de inicio y mantenimiento estudiada fue de 40 mg al dia.

Posologia despues de trasplantes: Despues de un trasplante de organo, se recomienda una dosis inicial de 20 mg al dia en los pacientes que reciben tratamiento inmunosupresor (ver apartado 4.5). Dependiendo de la respuesta de los parametros lipidicos, la dosis puede ajustarse hasta 40 mg bajo estrecha supervision medica (ver apartado 4.5).

Ninos y adolescentes (8-18 anos) con hipercolesterolemia familiar heterocigotica: El rango de dosis recomendado para ninos y adolescentes entre 8 y 13 anos es de 10 mg a 20 mg una vez al dia, ya que no se han estudiado dosis mayores de 20 mg en esta poblacion. Para los adolescentes entre 14 y 18 anos el rango de dosis recomendado es de 10 mg a 40 mg una vez al dia (en el caso de las ninas y las adolescentes en edad fertil, ver apartado 4.6; resultados del estudio clinico, ver apartado 5.1).

Pacientes ancianos: No es necesario ajustar la dosis en estos pacientes a menos que haya factores de riesgo predisponentes (ver apartado 4.4).

Insuficiencia renal o hepatica: En pacientes con alteracion moderada o grave de la funcion renal o con alteracion hepatica significativa se recomienda administrar una dosis inicial de 10 mg al dia. La dosis debe ajustarse segun la respuesta de los parametros lipidicos y bajo supervision medica.

Tratamiento concomitante: El efecto hipolipemiante de PRAREDUCT sobre el colesterol total y el colesterol-LDL aumenta cuando se asocia con una resina secuestradora de acidos biliares (p. ej. colestiramina, colestipol). PRAREDUCT debe administrarse una hora antes o, al menos, cuatro horas despues de la resina (ver apartado 4.5). Los pacientes en tratamiento con ciclosporina con o sin otros medicamentos inmunosupresores, deben iniciar la terapia con 20 mg de pravastatina una vez al dia y el ajuste de la dosis a 40 mg debe hacerse con precaucion (ver apartado 4.5).

- Hipersensibilidad al principio activo o a alguno de los excipientes.

- Enfermedad hepatica activa, incluyendo elevaciones persistentes e inexplicables de las transaminasas sericas cuando su limite se encuentre 3 veces por encima del limite superior de la normalidad (ver apartado 4.4).

- Embarazo y lactancia (ver apartado 4.6). 4.4 Advertencias y precauciones especiales de empleo

No se ha evaluado la eficacia de pravastatina en pacientes con hipercolesterolemia familiar homocigotica. El tratamiento no es adecuado cuando la hipercolesterolemia se debe a una elevacion del colesterol-HDL. Como sucede con otros inhibidores de la HMG-CoA reductasa, no se recomienda la combinacion de pravastatina con fibratos. En ninos en edad prepuberal, antes de iniciar el tratamiento el medico debe valorar cuidadosamente la relacion beneficio/riesgo del mismo.

Trastornos hepaticos: Al igual que con otros agentes reductores del colesterol, se han observado incrementos moderados de los niveles de transaminasas hepaticas. En la mayoria de los casos, los niveles de transaminasas hepaticas han vuelto a su nivel pretratamiento sin necesidad de suspender el tratamiento. Debe prestarse atencion especial a los pacientes que presenten un incremento de los niveles de transaminasas y el tratamiento debe suspenderse si se presentan elevaciones de alanin-aminotransferasa (ALT) y de aspartato - aminotransferasa (AST) que excedan tres veces el limite superior de la normalidad y se mantengan.

Pravastatina debe administrarse con precaucion a pacientes con antecedentes de enfermedad hepatica o que consuman una gran cantidad de alcohol.

Trastornos musculares: Al igual que con otros inhibidores de la HMG-CoA reductasa (estatinas), pravastatina se ha asociado a la aparicion de mialgia, miopatia y, muy raramente, rabdomiolisis. La posibilidad de miopatia debe valorarse en cualquier paciente que se encuentre en tratamiento con estatinas y que presente sintomas musculares inexplicados como dolor o sensibilidad, debilidad muscular o calambres musculares. En estos casos, se deben determinar los niveles de creatina-cinasa (CK) (ver a continuacion). El tratamiento con estatinas debe interrumpirse temporalmente cuando los niveles de CK se encuentren 5 veces por encima del limite superior de la normalidad o cuando aparezcan sintomas clinicos severos. La aparicion de rabdomiolisis, con o sin fallo renal secundario, ocurre muy raramente (aproximadamente 1 caso entre 100.000 pacientes/ano). La rabdomiolisis es un trastorno agudo del musculo esqueletico potencialmente mortal que puede desarrollarse en cualquier momento durante el tratamiento y que se caracteriza por una destruccion masiva de musculo asociada a un aumento importante de la CK (normalmente entre 30 o 40 veces por encima del limite superior de la normalidad) seguida de mioglobinuria. Parece que el riesgo de aparicion de miopatia asociado al tratamiento con estatinas es dependiente de la exposicion y, por tanto, puede variar con cada farmaco (debido a diferencias en la lipofilia y la farmacocinetica), incluyendo su posologia y su capacidad para tener interacciones medicamentosas. Aunque no hay una contraindicacion muscular para la prescripcion de una estatina, determinados factores pueden aumentar el riesgo de toxicidad muscular y, por tanto, justificar una evaluacion cuidadosa de la relacion beneficio/riesgo y un control medico especial. En estos pacientes esta indicada la determinacion de los niveles de CK antes de comenzar el tratamiento con estatinas (ver a continuacion).

El riesgo y la intensidad de los trastornos musculares durante el tratamiento con estatinas aumentan con la administracion concomitante de medicamentos que interaccionan. El uso de fibratos solos se asocia ocasionalmente a miopatia. En general, debe evitarse la administracion conjunta de una estatina y fibratos. La coadministracion de estatinas y acido nicotinico tambien debe administrarse con precaucion. Se ha descrito tambien un aumento de la incidencia de miopatia en pacientes que reciben otras estatinas en combinacion con inhibidores del metabolismo del citocromo P450. Esto podria deberse a interacciones farmacocineticas que no se han documentado para pravastatina (ver apartado 4.5). Cuando los sintomas musculares se asocian a tratamiento con estatinas, normalmente suelen resolverse despues de la suspension del tratamiento.

MINISTERIO Determinacion de la creatina-cinasa e interpretacion:

En pacientes asintomaticos en tratamiento con estatinas no se recomienda realizar determinaciones rutinarias de la creatina-cinasa (CK) o de los niveles de otras enzimas musculares. Sin embargo, se recomienda la determinacion de los niveles de CK antes de comenzar el tratamiento en pacientes que presenten factores de predisposicion especiales y en pacientes que desarrollen sintomas musculares durante el tratamiento con estatinas, tal y como se describe a continuacion. Si los niveles basales de CK estan significativamente elevados (5 veces por encima del limite superior de la normalidad), la determinacion debera repetirse a los 5-7 dias posteriores para confirmar estos resultados. La determinacion de los niveles de CK se debe interpretar en el contexto de otros posibles factores que pueden producir lesion muscular transitoria, como el ejercicio fisico intenso o traumatismo muscular.

Antes del inicio del tratamiento: Se debe tener precaucion en pacientes que presenten factores de predisposicion como insuficiencia renal, hipotiroidismo, historia previa de toxicidad muscular por una estatina o un fibrato, historia personal o familiar de enfermedades musculares hereditarias o abuso de alcohol. En estos casos, se deben determinar los niveles de CK antes de comenzar el tratamiento. Tambien se debe valorar la determinacion de los niveles de CK antes de comenzar el tratamiento en personas mayores de 70 anos, especialmente en aquellos que presenten otros factores de predisposicion. Si los niveles basales de CK estan significativamente elevados (5 veces por encima del limite superior de la normalidad), el tratamiento no debera instaurarse y los resultados se deben volver a determinar a los 5 - 7 dias posteriores. Los niveles basales de CK tambien pueden servir de referencia en caso de un incremento posterior durante el tratamiento con estatinas.

Durante el tratamiento: Debe aconsejarse a los pacientes que comuniquen rapidamente cualquier dolor muscular, sensibilidad, debilidad o calambres musculares inexplicados. En estos casos, se deben determinar los niveles de CK. Si se detecta un nivel de CK significativamente elevado (5 veces por encima del limite superior de la normalidad), el tratamiento con estatina se debe interrumpir. Tambien se debe valorar la interrupcion del tratamiento si los sintomas musculares son severos y causan malestar continuo, incluso si los niveles de CK permanecen igual o por debajo de 5 veces el limite superior de la normalidad. Si los sintomas desaparecen y los niveles de CK se normalizan, se puede considerar la reintroduccion de la estatina a la dosis mas baja y bajo una estrecha vigilancia del paciente. Si se sospecha una enfermedad muscular hereditaria en dicho paciente, no se recomienda reiniciar el tratamiento con estatinas.

Lactosa: Este medicamento contiene lactosa. Los pacientes con intolerancia hereditaria a galactosa, insuficiencia de lactasa de Lapp o malabsorcion de glucosa-galactosa, no deben tomar este medicamento.

4.5 Interaccion con otros medicamentos y otras formas de interaccion

Fibratos: El uso de fibratos solos se asocia ocasionalmente a la aparicion de miopatia. Se ha notificado un aumento del riesgo de reacciones adversas musculares, incluyendo rabdomiolisis, cuando los fibratos se administran conjuntamente con otras estatinas. Ya que estas reacciones adversas no se pueden descartar con pravastatina debe evitarse, generalmente, el uso combinado de pravastatina y fibratos (p. ej. gemfibrozilo, fenofibrato) (ver apartado 4.4). Si esta combinacion fuera necesaria, hay que realizar un cuidadoso control clinico y de los niveles de CK en los pacientes que se encuentren en tratamiento con esta combinacion. Colestiramina/Colestipol: La administracion concomitante origino un descenso de, aproximadamente, el 40% al 50% de la biodisponibilidad de pravastatina. Cuando pravastatina se administro una hora antes o cuatro horas despues de colestiramina o una hora antes que colestipol y una comida estandar, no se observo una disminucion clinicamente significativa en la biodisponibilidad o en el efecto terapeutico (ver apartado 4.2).

Ciclosporina: La administracion concomitante de pravastatina y ciclosporina produce un incremento, aproximadamente, de 4 veces la exposicion sistemica a pravastatina. Sin embargo, en algunos pacientes, el incremento de la exposicion a pravastatina puede ser mayor. Se recomienda un control clinico y bioquimico de los pacientes que esten recibiendo esta combinacion (ver apartado 4.2). Warfarina y otros anticoagulantes orales: La biodisponibilidad de pravastatina en el estado de equilibrio no se altero despues de su administracion con warfarina. La administracion cronica de los dos productos no produjo ningun cambio en el efecto anticoagulante de la warfarina.

Productos metabolizados por el citocromo P450: Pravastatina no se metaboliza de manera clinicamente significativa por el sistema del citocromo P450. Por esta razon, los productos que se metabolizan por, o que inhiben el sistema del citocromo P450 se pueden anadir a un regimen de tratamiento estable con pravastatina sin producir cambios significativos en los niveles plasmaticos de pravastatina, a diferencia de lo observado con otras estatinas. Se ha demostrado especificamente la ausencia de interacciones farmacocineticas significativas con pravastatina y otros productos, especialmente aquellos que son sustratos/inhibidores de CYP3A4, tales como diltiazem, verapamilo, itraconazol, ketoconazol, inhibidores de la proteasa, zumo de pomelo e inhibidores de CYP2C9 (por ejemplo, fluconazol).

En uno de los dos estudios de interaccion con pravastatina y eritromicina, se observo un incremento estadisticamente significativo del AUC (70%) y la Cmax (121%) de pravastatina. En un estudio similar con claritromicina, se observo un incremento estadisticamente significativo del AUC (110%) y la Cmax (127%). Aunque no fueron modificaciones relevantes, se debe tener precaucion especial cuando se administra pravastatina con eritromicina o claritromicina.

Otros productos: No se observaron diferencias estadisticamente significativas en la biodisponibilidad cuando se administro pravastatina en estudios de interaccion con acido acetilsalicilico, antiacidos (una hora antes de pravastatina), acido nicotinico o probucol.

4.6 Embarazo y lactancia

Embarazo: Pravastatina esta contraindicada durante el embarazo y solo debe administrarse a mujeres en edad fertil cuando sea poco probable que esas pacientes se queden embarazadas y hayan sido informadas del posible riesgo. Se recomienda tener especial cuidado con las adolescentes en edad fertil para estar seguros de que entienden el posible riesgo que se asocia al tratamiento con pravastatina durante el embarazo. Si una paciente tiene previsto quedarse embarazada o se queda embarazada, debe informar al medico inmediatamente y debe interrumpir el tratamiento con pravastatina, debido al posible riesgo para el feto.

Lactancia: En la leche humana se excreta una pequena cantidad de pravastatina, por lo tanto pravastatina esta contraindicada durante la lactancia (ver apartado 4.3). 4.7 Efectos sobre la capacidad para conducir y utilizar maquinas

Pravastatina no tiene o tiene una influencia insignificante sobre la capacidad de conducir y utilizar maquinas. Sin embargo, cuando se conduzca o se utilicen maquinas, se debe tener en cuenta que puede ocurrir mareo durante el tratamiento.

4.8 Reacciones adversas

Las reacciones adversas mencionadas a continuacion se encuentran agrupadas, segun su frecuencia, en: muy frecuentes ( 1/10); frecuentes ( 1/100,



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Tefanyl, Tefanyl

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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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TEFABLOC

LARGE SPECTRUM OF FEATURES

The TEFABLOC TM range combines the most extreme properties to meet all types of specifications:

Ultra soft to semi-rigid

Higher UV resistance than most other TPEs

Elastic Memory

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Matt to glossy surface appearance

Flame retardant

etc.

WIDE PROCESSING WINDOW

Beyond the expected properties, TEFABLOC TM formulations are always prepared to offer a wide processing window in order to fit with the most sophisticated injection concepts. The consistency in rheology and the high standard of appearance also characterize the TEFABLOC TM, also for the extrusion of complex profiles.

NON-TOXIC

For applications such like toy, skin contact, contact with food, specific formulations have been developed. Contact us.

Main properties

Product series

The semi-dynamic sealing system is intended for use with moving windows and comprises the following

The lowest TEFABLOC TM TPE density combined with its compatibility with PP, which means the steel can be replaced with stiffeners, allow for a decrease of up to 30% in weight.

Static sealing prevents air and dirt from working its way in between the components of the bodywork, thus ensuring acoustic comfort and improving the cleanliness of certain parts of the vehicle which may come into contact with clothing.

Furthermore, in certain highly-exposed areas, such as the windscreen contour, the uniformity of the colouring, the matt finish and UV ageing-resistance are all key parts of the aesthetics of the vehicle.

The range also offers an extensive choice of materials for the production of water-tight seals for doors and windows, some approved by the major European bodies (CSTB, SKZ and BSI), adapted to suit various types of technology, including PVC, wood and aluminium applications.

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Research participation Option to participate in medical surveys & studies*

Tefanyl (Ketotifen)

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DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

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Becloforte (Discontinued In The Uk - June 2007), Becloforte

Becloforte (discontinued in the UK - June 2007)

What is it used for?

How does it work?

Becloforte inhaler contains the active ingredient beclometasone dipropionate (previously spelt beclomethasone in the UK), which is a type of medicine known as a corticosteroid. (NB. Beclometasone inhalers are also available without a brand name, ie as the generic medicine.)

Corticosteroids are hormones that are produced naturally by the adrenal glands. They have many important functions, including control of inflammatory responses. Beclometasone is a synthetic corticosteroid and is used to decrease inflammation in the lungs. (NB. Corticosteroids are often simply called steroids, but it should be noted that they are very different from another group of steroids, called anabolic steroids, which have gained notoriety because of their abuse by some athletes and body builders.)

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When beclometasone is inhaled into the lungs it is absorbed into the cells of the lungs and airways. Here it works by preventing the release of certain chemicals from the cells. These chemicals are important in the immune system and are normally involved in producing immune and allergic responses that result in inflammation. By decreasing the release of these chemicals in the lungs and airways, inflammation is reduced.

In asthma, the airways tighten due to inflammation and can also be blocked by mucus. This makes it difficult for air to get in and out of the lungs. By preventing the inflammation and excess mucus formation, beclometasone makes it easier to breathe and helps prevent asthma attacks.

Beclometasone is taken using an inhaler device to treat asthma. Inhaling the medicine allows it to act directly in the lungs where it is needed most. It also reduces the potential for side effects occurring in other parts of the body, as the amount absorbed into the blood through the lungs is lower than if it is taken by mouth.

Beclometasone taken by inhaler is known as a preventer. This is because it is taken regularly to reduce the inflammation in the lungs and prevent asthma attacks. Symptoms usually start to get better between three to seven days after starting treatment. However, it is important to continue using this medicine regularly, even after your asthma symptoms have improved, in order to prevent them coming back.

Warning!

This medicine is known as a preventer and it should be taken regularly to prevent asthma attacks. It should not be used to relieve an asthma attack, as it will not work for this purpose. An asthma attack needs to be treated with a medicine that quickly opens the airways, such as salbutamol or terbutaline. These are known as relievers, and you should make sure you carry your reliever inhaler with you at all times to relieve an asthma attack if it happens. Consult your doctor if you need to use your reliever more frequently than normal, or if it becomes less effective at treating attacks, as this may indicate that your asthma is getting worse and your doctor may need to prescribe you another medicine.

Do not exceed the dose of this medicine that your doctor has prescribed for you.

You should not suddenly stop taking this medicine unless your doctor tells you otherwise, as your asthma symptoms are likely to return.

Inhalers may cause an unexpected increase in wheezing and difficulty breathing (paradoxical bronchospasm) straight after using them. If this happens, don't use the inhaler again, use your reliever inhaler to open your airways and consult your doctor immediately.

Inhaled corticosteroids can sometimes cause a fungal infection in the mouth called oral thrush. To minimise the chances of this you should rinse your mouth with water or clean your teeth after inhaling each dose. Using a spacer device can also help avoid this problem.

Inhaled corticosteroids have considerably fewer side effects than steroids taken by mouth. However, when taken for long periods of time at high doses, inhaled steroids do have the potential to cause side effects such as glaucoma. cataracts. thinning of the bones (osteoporosis ), slowed growth in children and adolescents, and to suppress the functioning of the adrenal glands (glands that produce natural steroid hormones). For this reason your doctor will prescribe the lowest effective dose to control your symptoms, and monitor for these side effects. Do not exceed the dose of this medicine that your doctor has prescribed for you. It is recommended that children receiving long-term treatment with corticosteroids have their growth monitored. If a child's growth appears to be slowed your doctor may refer them to a paediatrician. For further information talk to your doctor or pharmacist.

People with severe asthma should have regular blood tests to monitor the amount of potassium in their blood. This is because low oxygen levels in the blood (hypoxia) and various asthma medicines can lower blood potassium levels.

Use with caution in

Not to be used in

Known sensitivity or allergy to any ingredient.

Becloforte inhaler is not recommended for children.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine should be used with caution during pregnancy. However, it is important that asthma is well controlled in pregnant women. Wherever possible, asthma medications should be taken by inhaler, as this minimises the amount of medicine that enters the bloodstream and crosses the placenta to the baby. Seek medical advice from your doctor.

In general, the amount of corticosteroid that passes into the breast milk after using an inhaler is negligable and probably too small to be harmful to the baby. However, you should seek medical advice from your doctor before breastfeeding while using this medicine.

Label warnings

Do not stop taking this medication except on your doctor's advice.

Follow the printed instructions you have been given with this medication.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Yeast infection of the mouth (oral thrush)

Throat irritation

Hoarseness

Cough (if this inhaler makes you cough, using your reliever inhaler before using this one may help)

Unexpected narrowing of the airways (paradoxical bronchospasm)

Systemic effects (eg, Cushing's syndrome, adrenal suppression, slowed growth in children and adolescents, decreased bone mineral density, cataract and glaucoma) may occur after high doses for prolonged periods - see warning above.

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

Tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe .

Beclometasone may potentially decrease the amount of potassium in the blood. If it is taken in combination with any of the following medicines, which can also lower potassium in the blood, the risk of a low blood potassium level (hypokalaemia) is increased:

xanthine derivates, such as theophylline or aminophylline

oral corticosteroids, such as prednisolone

beta 2 agonists, such as salbutamol, salmeterol

diuretics, such as bendroflumethiazide and furosemide.

A low blood potassium level can have serious effects, which is why people with severe asthma, who may be taking several of these medicines, should have their blood potassium level monitored regularly.

Other medicines containing the same active ingredient

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Algopain-Eze 140 Mg Medicated Plaster, Dolostrip

ALGOPAIN-EZE 140 MG MEDICATED PLASTER

Transcript

PACKAGE LEAFLET: INFORMATION FOR THE USER ALGOPAIN-Eze 140 mg medicated plaster (Diclofenac Sodium)

Read all of this leaflet carefully before you start using this medicine. This medicine is available without prescription. However, you still need to use ALGOPAIN-Eze 140 mg medicated plaster carefully to get the best results from it. • Keep this leaflet. You may need to read it again. • Ask your pharmacist if you need more information or advice. • You must contact a doctor if your symptoms worsen or do not improve after 3 days. • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section4. In this leaflet: 1. What ALGOPAIN-Eze 140 mg medicated plaster is and what it is used for 2. Before you use ALGOPAIN-Eze 140 mg medicated plaster 3. How to use ALGOPAIN-Eze 140 mg medicated plaster 4. Possible side effects 5. How to store ALGOPAIN-Eze 140 mg medicated plaster 6. Further information 1.

What ALGOPAIN-Eze 140 mg medicated plaster is and what it is used for

Diclofenac sodium is a medicine that reduces pain. It belongs to the non-steroidal anti-inflammatory drug (NSAID) group. For adults and adolescents aged 16 years and over: ALGOPAIN-Eze 140 mg medicated plaster is used for short-term treatment in the local symptomatic treatment of pain associated with acute strains, sprains or bruises on the arms and legs as a result of injuries, e. g. sports injuries.

Before you use ALGOPAIN-Eze 140 mg medicated plaster

Do not use this medicine • if you are hypersensitive (allergic) to diclofenac, propylene glycol, butylhydroxytoluene or any of the other ingredients of ALGOPAIN-Eze 140 mg medicated plaster. (See section 6 for a comprehensive list of ingredients). • if you are hypersensitive (allergic) to any other non-steroidal anti-inflammatory drug (NSAID, e. g. aspirin, ibuprofen). • if you developed asthma, swelling of the skin or swelling and irritation inside the nose after taking aspirin or other NSAIDs. • if you are suffering from an active peptic ulcer • on injured skin (e. g. skin abrasions, cuts, burns), infected skin or eczema • during the last three months of pregnancy • in children and adolescents less than 16 years old

Take special care with this medicine • if you suffer or have previously suffered from bronchial asthma or allergies, you may experience a bronchial muscle cramp (bronchospasm), which makes breathing difficult. • if you get a skin rash, remove the medicated plaster immediately and stop the treatment. • if you have kidney, heart or liver problems, or if you suffer or have previously suffered from a gastrointestinal ulcer, intestinal inflammation or a tendency to bleeding. Side effects can be reduced by using the lowest effective dose for the shortest possible time. IMPORTANT precautions: • if symptoms persist for longer than 3 days or worsen. you should talk to a doctor. • do not use the medicated plaster on the eyes or internal body surfaces (e. g. nostrils, airways, ear canals) or allow it to come into contact with them. • elderly patients should use this medicine with caution, as they are more likely to experience side effects. • do not use if you are applying or taking other medicines containing diclofenac. • do not use if you are applying or taking other NSAID painkillers or aspirin. After taking off the medicated plaster avoid exposing the treated area to direct and solarium sunlight for about one day in order to reduce the risk of sensitivity to light.

Children and adolescents This medicine should not be used in children and adolescents aged 16 or below. Using with other medicines Please tell your doctor or pharmacist if you are taking/using or have recently taken/used any other medicines, including medicines obtained without a prescription. Provided that this medicine is used correctly, very little diclofenac is absorbed into the body, reducing the risk of interactions with other medicines. Pregnancy and breast-feeding Ask your doctor or pharmacist for advice before using any medicine. During the first six months of pregnancy, you should only use this medicine after speaking to your doctor. During the last three months of pregnancy, do not use this medicine, as there is an increased risk of complications for mother and baby (see “Do not use this medicine”). Very small quantities of diclofenac pass into the breast milk. As no adverse effects are known for the baby, there is no need to stop breast-feeding during short-term use of this medicine. However, this medicine should not be directly applied onto the breast area. Driving and using machines This medicine does not affect your ability to drive and use machines. Important information about some of the ingredients of this medicine Propylene glycol may cause skin irritation. Butylhydroxytoluene can cause local skin reactions (e. g. contact dermatitis), or irritation of the eyes and internal body surfaces (e. g. nostrils, airways, ear canals). 3.

How to use ALGOPAIN-Eze 140 mg medicated plaster

Always use this medicine exactly as your doctor or pharmacist has told you to or according to this Package Leaflet. You should check with your doctor or pharmacist if you are not sure. The usual dose is:

Attach one medicated plaster to the painful area twice daily, in the morning and the evening. The maximum total daily dose is 2 medicated plasters, even if there is more than one injured area to be treated. Treat only one painful area at once. Children and adolescents There are insufficient data on efficacy and safety for children and adolescents below 16 years of age.

Method of use For application to the skin only. Do not take orally!

1. Cut open the bag containing the medicated plaster along the marking. 2. Take out one medicated plaster and carefully reseal the bag by pressing on the closure. 3. Remove the protective film from the adhesive surface of the medicated plaster. 4. Now apply the medicated plaster to the painful area. If necessary, the medicated plaster can be held in place using an elastic net bandage. Do not use the medicated plaster together with an air-tight (occlusive) bandage. You should not cut the medicated plaster. Used plasters should be folded in half, with the sticky side inwards. Duration of use Do not use this medicine for longer than 3 days without your doctor’s advice. The use of this medicine for a longer time must be discussed with a doctor and should not exceed 7 days. If you have the impression that the effect of this medicine is too strong or too weak, please talk to your doctor or pharmacist. If you use more ALGOPAIN-Eze 140 mg medicated plaster than you should Please tell your doctor if marked side effects occur after incorrect use of this medicine or accidental overdose (e. g. in children). They will be able to advise you of any further measures which may be necessary, depending on the severity of poisoning. If you forget to use ALGOPAIN-Eze 140 mg medicated plaster Do not use a double dose to make up for a forgotten dose. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. 4.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. The following frequency conventions are used in the evaluation of side effects: Tell your doctor immediately and stop using the plaster, if you notice any of the following: • sudden itchy rash (hives); • swelling of the hands, feet, ankles, face, lips, mouth or throat; • difficulty breathing;

• drop in blood pressure or weakness. You may experience the following side effects: Common (less than 1 in 10 persons treated): Local skin reactions, such as skin reddening, a burning sensation, itching, inflamed skin redness, skin rash, sometimes with pustules or wheals. Uncommon (less than 1 in 100 persons treated): Hypersensitivity reactions or local allergic reactions (contact dermatitis). In patients who have applied active substances to the skin belonging to the same drug class as diclofenac, there have been isolated reports of generalised skin rash, hypersensitivity reactions, such as swelling of the skin and mucous membranes and anaphylactic-type reactions with acute circulatory regulation disorders and sensitivity to light. Absorption of diclofenac into the body via the skin is very low compared with the concentration of the active substance in the blood following oral intake of diclofenac. The probability of side effects occurring in the body as a whole (such as gastrointestinal or kidney disturbances or breathing difficulties) is therefore very low. But if you do get these or if any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard By reporting side effects you can help provide more information on the safety of this medicine. 5.

How to store ALGOPAIN-Eze 140 mg medicated plaster

Keep out of the reach and sight of children. Do not use this medicine after the expiry date which is stated on the outer carton and the bag after EXP. The expiry date refers to the last day of that month. Do not store above 25 ?C. Store in the original package in order to prevent the patches from drying out and to protect them from light. Keep the bag tightly closed in order to prevent the patches from drying out. Can be stored for 4 months after first opening of a bag. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment. 6.

What ALGOPAIN-Eze 140 mg medicated plaster contains The active substance is diclofenac sodium. Each medicated plaster contains 140 mg diclofenac sodium. The other ingredients are glycerol; propylene glycol (E1520); diisopropyl adipate; sorbitol, liquid (crystallising) (E420); carmellose sodium; polyacrylic acid sodium salt; basic butylated methacrylate copolymer; disodium edetate; sodium sulphite, anhydrous (E221); butylhydroxytoluene (E321); aluminium-potassium-bis(sulphate); silica, colloidal anhydrous; light kaolin (natural); macrogol lauryl ether (9 EO units); levomenthol; tartaric acid; purified water; unwoven polyester support; polypropylene protective film.

What ALGOPAIN-Eze 140 mg medicated plaster looks like and contents of the pack ALGOPAIN-Eze 140 mg medicated plaster is a 10 x 14 cm medicated plaster with a white to light brown paste spread as an even layer onto unwoven support and with a detachable protective film. ALGOPAIN-Eze 140 mg medicated plaster is available in packs with 2, 5, 10 or 14 medicated plasters in resealable bags each containing 2 or 5 medicated plasters. Not all pack sizes may be marketed. Marketing Authorisation Holder and Manufacturer Marketing Authorisation Holder: ratiopharm GmbH, Graf-Arco-Strasse 3, D-89079 Ulm, Germany. Manufacturer: Merckle GmbH, Ludwig-Merckle-Stra?e 3, 89143 Blaubeuren, Germany. This medicinal product is authorised in the Member States of the EEA under the following names: Austria: Dolostrip 140 mg wirkstoffhaltiges Pflaster Belgium: Kinespir Patch 140 mg pleister Czech Republic: Olfen 140 mg lecive naplasti Germany: Diclofenac-ratiopharm Schmerzpflaster Hungary: Algoplast-ratiopharm 140 mg gyogyszeres tapasz Italy: Diclofenac Pharmentis 140 mg cerotti medicati Slovakia: Diclobene 140 mg Spain: DICLODOLOR 140 mg APOSITO ADHESIVO MEDICAMENTOSO United Kingdom: ALGOPAIN-Eze 140 mg medicated plaster For a large print, audio, Braille or CD-rom version of this patient information leaflet, phone 02392 313592. This leaflet was last revised in March 2015.

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



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Effexor Xr, Venlafab

What is this medicine?

VENLAFAXINE is used to treat depression, anxiety and panic disorder.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: anorexia or weight loss glaucoma high blood pressure, heart problems or a recent heart attack high cholesterol levels or receiving treatment for high cholesterol kidney or liver disease mania or bipolar disorder seizures (convulsions) suicidal thoughts or a previous suicide attempt thyroid problems an unusual or allergic reaction to venlafaxine, other medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding

How should I take this medicine?

Take this medicine by mouth with a full glass of water. Do not cut, crush or chew this medicine. Take it with food. Try to take your medicine at about the same time each day. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following: duloxetine medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl medicines for weight control or appetite nefazodone procarbazine St. John's wort, Hypericum perforatum tryptophan

This medicine may also interact with the following: amphetamine or dextroamphetamine aspirin and aspirin-like medicines cimetidine clozapine linezolid medicines for heart rhythm or blood pressure medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin NSAIDS, medicines for pain and inflammation, like ibuprofen or naproxen other medicines for depression, anxiety, or psychotic disturbances ritonavir tramadol

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while taking this medicine?

Visit your doctor or health care professional for regular checks on your progress. You may have to take this medicine for 4 weeks before you feel better. If you have been taking this medicine for some time, do not suddenly stop taking it. You must gradually reduce the dose to avoid side effects. Ask your doctor or health care professional for advice.

Patients and their families should watch out for depression or thoughts of suicide that get worse. Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

This medicine can cause an increase in blood pressure or a faster heart beat. Check with your doctor or health care professional.

You may get drowsy, dizzy or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may increase dizziness or drowsiness. Avoid alcoholic drinks.

This medicine can make your mouth dry. Chewing sugarless gum, sucking hard candy and drinking plenty of water will help.

Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Some ingredients may increase possible side effects.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue breathing problems changes in vision hallucination, loss of contact with reality seizures suicidal thoughts or other mood changes trouble passing urine or change in the amount of urine unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): change in sex drive or performance constipation increased sweating loss of appetite nausea tremors weight loss

This list may not describe all possible side effects.

Where can I keep my medicine?

Keep out of the reach of children.

Store at a controlled temperature between 20 and 25 degrees C (68 degrees and 77 degrees F), in a dry place. Throw away any unused medicine after the expiration date.

What is this medicine?

VENLAFAXINE is used to treat depression, anxiety and panic disorder.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: anorexia or weight loss glaucoma high blood pressure, heart problems or a recent heart attack high cholesterol levels or receiving treatment for high cholesterol kidney or liver disease mania or bipolar disorder seizures (convulsions) suicidal thoughts or a previous suicide attempt thyroid problems an unusual or allergic reaction to venlafaxine, other medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding

How should I take this medicine?

Take this medicine by mouth with a full glass of water. Do not cut, crush or chew this medicine. Take it with food. Try to take your medicine at about the same time each day. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following: duloxetine medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl medicines for weight control or appetite nefazodone procarbazine St. John's wort, Hypericum perforatum tryptophan

This medicine may also interact with the following: amphetamine or dextroamphetamine aspirin and aspirin-like medicines cimetidine clozapine linezolid medicines for heart rhythm or blood pressure medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin NSAIDS, medicines for pain and inflammation, like ibuprofen or naproxen other medicines for depression, anxiety, or psychotic disturbances ritonavir tramadol

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while taking this medicine?

Visit your doctor or health care professional for regular checks on your progress. You may have to take this medicine for 4 weeks before you feel better. If you have been taking this medicine for some time, do not suddenly stop taking it. You must gradually reduce the dose to avoid side effects. Ask your doctor or health care professional for advice.

Patients and their families should watch out for depression or thoughts of suicide that get worse. Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

This medicine can cause an increase in blood pressure or a faster heart beat. Check with your doctor or health care professional.

You may get drowsy, dizzy or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may increase dizziness or drowsiness. Avoid alcoholic drinks.

This medicine can make your mouth dry. Chewing sugarless gum, sucking hard candy and drinking plenty of water will help.

Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Some ingredients may increase possible side effects.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue breathing problems changes in vision hallucination, loss of contact with reality seizures suicidal thoughts or other mood changes trouble passing urine or change in the amount of urine unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): change in sex drive or performance constipation increased sweating loss of appetite nausea tremors weight loss

This list may not describe all possible side effects.

Where can I keep my medicine?

Keep out of the reach of children.

Store at a controlled temperature between 20 and 25 degrees C (68 degrees and 77 degrees F), in a dry place. Throw away any unused medicine after the expiration date.



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Axoven

AXOVEN The specifics

box of 120 capsules

Dietary supplement herbal. vitamins and selenium

THE BENEFICIAL EFFECTS

Vitamin C helps to normal collagen formation for the normal function of blood vessels . Vitamin E and vitamin C can help protect cells against oxidative stress . Selenium and vitamin E help protect cells against oxidative stress. AXOVEN is also composed of:

Redbush dry extract ( daily intake. 400mg) Horse chestnut dry extract ( daily intake. 300mg) Lemon dry extract ( daily intake. 143mg ) green tea dry extract ( daily intake. 125mg) Beta-carotene ( retinol equivalent )

AXOVEN is a dietary supplement does not replace a varied and balanced diet and a healthy lifestyle.

Keep out of reach of young children. Pregnant women. do not exceed the recommended amount for vitamin A ( provided in the form of beta - carotene).

2 capsules per day with a glass of water (125ml). Do not overtake the recommended dosis.

Redbush dry extract (Vitis vinifera), Horse chesnut dry extract (Aesculus hippocastanum), coating: white capsule (hydroxypropylmethyl cellulose, thickener: gellan gum E418, colouring: titanium dioxide E171), Lemon dry extract (Citrus limon), green tea dry extract (Camellia sinensis), Vitamin C, agent: microcristalline cellulose E460, Beta-carotene, anti-caking agent: magnesium stearate E470b, selenium yeast.



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PROFUNGAL TAB 200MG

Komposisi : Tiap tablet salut selaput mengandung ketokonazol. 200 mg

Farmakologi : PROFUNGAL merupakan anti jamur golongan imidazol pertama yang dapat diberikan per oral. Seperti imidazol lainnya, PROFUNGAL mempunyai spektrum dan aktivitas anti jamur yang luas dan tinggi. PROFUNGAL dengan efektivitas oral, mewakili suatu terobosan baru dalam bidang pengobatan infeksi-infeksi jamur. Imidazol mengganggu biosintesa ergosterol, yang merupakan komponen vital dari membran sel jamur, mengakibatkan permeabilitas sellular meningkat, kerusakan sel & kematian sel. Ketokonazol terutama bersifat fungistatik pada konsentrasi yang dicapai dengan dosis terapeutik yang lazim, dan Iebihefektif bila sel-sel jamur sedang bertumbuh dengan aktif.

PROFUNGAL, aktif terhadap berbagai mikosis sistemik dan mukokutaneus yang disebabkan oleh Blastomyces dermatitidis, Histoplasma capsulatum, Coccidioides immitis, Paracoccidioides brasiliensis, Cryptococcus neoformans, Candida spp, Dermatophytes, dan Malassezia furfur. Sampai saat ini belum pernah dilaporkan berkembangnya resistensi terhadap ketokonazol. PROFUNGAL dengan dosis oral 200 mg pada waktu makan menghasilkan kadar puncak plasma 2-5 ug/ml dalam 1-2 jam. Dengan dosis 400 mg, sekitar 5-9 ug/ml dalam 2 jam. Lebih dari 90 % obat terikat pada protein plasma, terutama albumin. Jumlah yang dapat mencapai cairan serebrospinal relatif dapat diabaikan.

PROFUNGAL didegradasi secara ekstensif di hati, menjadi beberapa metabolit yang tidak aktif. Kirakira 13 % dari dosis diekskresi melalui urin, dimana 2-4 % dalam bentuk utuh. Jalan ekskresi utama adalah bersama cairan empedu ke saluran cerna. Kecepatan eliminasinya bersifat "dose-dependent", waktu paruh plasma lebih kurang 90 menit pada dosis 200 mg, tetapi meningkat sampai hampir 4 jam jika diberi pada 800 mg.

Indikasi : 1. Pengobatan infeksi jamur sistemik (mikosis profunda), misal : - histoplasmosis pada paru-paru, tulang & sendi, jaringan, "disseminated disease". - blastomikosis. - parakokidioidomikosis (bentuk tertentu). - kokidioidomikosis (bentuk tertentu). - kandidiasis sistemik. 2. Kandidiasis mukokutaneus kronik (vaginal, oral, gastrointestinal), yang tidak responsif terhadap nistatin dan obat-obat lain.

Kontra indikasi : Hipersensitif terhadap ketokonazol.

Peringatan dan perhatian : 1. Ketokonazol mempunyai beberapa limitasi : a. Absorpsi per oral mungkin tidak menentu. b. Respon terhadap pengobatan lambat. Oleh karena itu ketokonazol kurang bermanfaat pada infeksi jamur berat yang akut, tetapi berguna untuk pengobatan supresi kronik. c. Untuk infeksi saluran kemih manfaatnya terbatas, karena telah dimetabolisme secara ekstensif sebelum diekskresi. d. Jangan digunakan untuk meningitis karena penetrasi ke cairan serebrospinal buruk. e. Tes kepekaan isolat secara invitro sering tidak berguna untuk memperkirakan respons klinis.

2. Ketokonazol dapat menyebabkan hepatotoksisitas, terutama tipe hepatoselular, tetapi dapat pula tipe kolestatik dan kombinasi dari keduanya. Insiden yang pernah dilaporkan adalah 1 dalam 10.000 pasien yang diobati. Kerusakan hati bersifat sementara, bila diketahui dini dan obat dihentikan. Nekrosis hati disusul koma dan kematian terjadi pada 2 pasien, dimana obat tetap diteruskan setelah muncul gejala-gejala. Hepatotoksisitas ini diduga suatu reaksi idiosinkrasi, tidak berkaitan dengan dosis perhari, dosis kumulatif atau lamanya terapi. Tes fungsi hati (misal. SGPT, SGOT, GAMMAGT, alkali fosfatase dan bilirubin) sebaiknya diperiksa sebelum terapi dan pada interval tertentu (tiap bulan atau lebih sering) selama terapi, khususnya pada pasien-pasien yang memerlukan terapi jangka panjang, dengan riwayat penyakit hati atau sedang diobati pula dengan obat-obat lain yang berpotensi hepatotoksik. Pasien sebaiknya diberitahu untuk melaporkan setiap tanda dan gejala yang mengesankan disfungsi hati (ikterus dengan jaundice, urin berwarna gelap dan faeces pucat atau anikterik dengan gejala-gejala hepatitis seperti demam, lemah, lelah, malaise, anoreksia, mual dan atau muntah), sehingga tes biokimia yang lazim dapat dilakukan. Hentikan obat bila tes fungsi hati menunjukkan abnormalitas (bahkan minor) yang menetap, memburuk, atau disertai gejala-gejala kerusakan hati. Kenaikan sementara kadar enzim hati tanpa tanda-tanda klinis atau gejala-gejala kelainan hati terjadi pada kira-kira 5-10 % pasien, yang akan normal kembali tanpa menghentikan pengobatan.

3. Gunakan ketokonazol dengan hati-hati pada penderita dengan kegagalan hati ; pantau kadar plasma dari obat ini.

4. Anafilaksis pernah dilaporkan setelah pemberian dosis pertama, walaupun jarang sekali.

5. Interaksi obat : a. "Coumarin-like anticoagulant". pantau efek antikoagulasi, karena efek ini dapat ditingkatkan oleh ketokonazol. b. Rifampisin. jangan digunakan bersamaan (rifampisin menyebabkan induksi enzym, yang mempercepat metabolisme ketokonazol). c. Siklosporin. pantau kadar plasma obat (ketokonazol berkompetisi dengan siklosporin pada metabolisme hepatis, dan peningkatan kadar plasma siklosporin meningkatkan potensi nefrotoksiknya). d. Fenitoin. pantau kadar plasma keduanya. e. Obat-obat hipoglikemik oral. dapat menyebabkan hipoglikemia berat. f. Amfoterisin B. jangan gunakan dalam kombinasi dengan ketokonazol (dapat terjadi antagonisme).

6. Kehamilan. ketokonazol teratogenik (sindaktilia dan oligodaktilia) pada tikus dengan dosis 80 mg/kg/hari (10 kali dosis maksimum yang dianjurkan pada manusia). Juga embriotoksik pada tikus dengan dosis lebih dari 80 mg/kg. Tambahan, ketokonazol pada dosis lebih tinggi dari 10 mg/kg, (1,25 kali dosis maksimum manusia) dapat menyebabkan distosia (partus sulit) bila diberikan selama trimester pertama kehamilan. Pada wanita hamil, belum ada penelitian yang adekuat dan disertai kontrol. Oleh karena itu PROFUNGAL selayaknya digunakan pada kehamilan hanya jika pertimbangan manfaat melampaui resiko terhadap janin.

7. Laktasi. hentikan menyusui selama menggunakan obat ini (diekskresi pada air susu).

8. Anak-anak. keamanan penggunaan pada anak-anak di bawah 2 tahun belum terbukti.

Efek samping : 1. Paling sering. mual dan/atau muntah (3 %), nyeri abdominal (1,2 %) dan pruritus (1,5 %). Pada kurang dari 1 % pasien. sakit kepala, pusing, konstipasi, diare, demam & menggigil, fotofobi, parestesia, gusi berdarah, dan trombositopenia. Reaksi-reaksi ini kebanyakan ringan dan sementara, jarang memerlukan penghentian obat.

2. Sedikit kasus anafilaksis setelah dosis pertama dan beberapa kasus reaksi hipersensitivitas termasuk urtikaria pernah dilaporkan.

3. Reaksi efek samping yang serius adalah toksisitas hati, yang jarang terjadi tetapi membutuhkan perhatian khusus (Iihat peringatan & perhatian), dan efek endokrin termasuk ginekomastia dan impotensi. Ketokonazol menghambat efek stimulasi gonadotropin pada testis dan mengakibatkan depresi sintesa testosteron. Dosis 200 mg sekali sehari menyebabkan penurunan ringan dan sementara dari kadar serum testosteron. Ginekomastia jarang terjadi, terutama dengan dosis relatif tinggi. Ketokonazol dosis tinggi dapat menyebabkan menurunnya libido pada sejumlah pasien.

Dosis dan cara pemberian : Dewasa. Dosis yang dianjurkan adalah 200 mg (satu tablet) sekali sehari. Pada infeksi berat atau bila respons kurang didalam waktu yang diharapkan, dosis dapat ditingkatkan menjadi 400 mg (2 tablet) sekali sehari. Anak-anak lebih dari 2 tahun: 3,3 - 6,6 mg/kg/hari sebagai dosis tunggal. 0 - 15 kg. sehari 3 kali 20 mg. 15 - 30 kg. sehari 1 kali 100 mg. lebih dari 30 kg. sehari 1 kali 200 mg. Anak-anak 2 tahun atau kurang dari 2 tahun: Dosis belum dapat ditentukan.

Lama pengobatan : Pengobatan sebaiknya dilanjutkan sampai semua hasil klinis dan laboratoris menunjukkan telah meredanya infeksi aktif. Periode pengobatan yang tidak tepat dapat memberikan hasil buruk dan mengawali suatu kekambuhan. - Kandidiasis vaginal. 2 tablet (400 mg) dosis tunggal selama 5 hari. - Kandidiasis oral. 10 hari. - Kandidiasis sistemik. 1-2 bulan. - Parakokidioidomikosis. 2-6 bulan. - Histoplasmosis. paling kurang 6 bulan. - Mikosis sistemik lainnya. paling kurang 6 bulan. - Kandidiasis mukokutaneus kronik. 2-18 bulan. Untuk absorpsi dan disolusi ketokonazol dibutuhkan lingkungan asam, oleh karena itu : a. Pasien dengan aklorhidria harus melarutkan tiap tablet dalam 4 ml larutan HCI 0,2 N, hisaplah larutan ini dengan sedotan (untuk menghindari kontak dengan gigi) dan kemudian minumlah segelas air. b. Obat-obat yang mengurangi keasaman lambung (mis. antasid, H2-blocker, antikolinergik), jika dibutuhkan pada saat yang sama, harus diberikan paling sedikit 2 jam setelah pemberian ketokonazol. Pengaruh dari makanan terhadap absorpsi ketokonazol masih kontroversial. Pemberian bersama makanan dapat mengurangi efek samping dari obat ini.

Kemasan : Dos berisi 5 strip @ 10 tablet. Reg. No. DKL9104408217A1 Dos berisi 10 strip @ 10 tablet. Reg. No. DKL9104408217A2

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rekao sam doktorici da mi se ponekad povraпїЅa, valjda kad imam tremu(niпїЅta straпїЅno),neznam ni ja zasto, vjerojatno je problem psihicke prirode, ali je rekla da me nece nigdje slati, niti mi nije nista htjela dati vec je glumila psihologa i govorila mi kako se rijesiti toga. zatim sam joj stalno napominjao da cu na izlet, pa mi je na kraju dala reglan, tablete za smirenje zeluca. i jos mi je rekla da se ne moraju piti redovito, vec kad mi zatreba.

procitao sam onaj papir koji se dobije s tabletama i tamo samo pise da se ne koristi s alkoholom jer moze doci do pospanosti. ako se dobro sjecam nista drugo nije pisalo vezano za alkohol.

pa me zanima da li se reglan moze popiti prije nego odem negdje piti alkohol i koliko alkohola mogu popiti nakon tih tableta?

Malo vas neпїЅe ubiti npr. jedna piva.

Registracija: Aug 2010.

Lokacija: ispred kompjutera

Malo vas neпїЅe ubiti npr. jedna piva.

znam, da, tako male kolicine sam vec isprobao i nije mi bilo nista, vec mene zanima za vece kolicine (recimo 4-5 ili vise casa mjesavine).

evo imam jedno pitanje, u petak je jedna zabava koju nebi smio prpoustit(bratiпїЅev roпїЅendan)ali imam jedan problem, pijem neke tablete jer imam facijalis parezu, tablete su medrol, virolex, b-komplex i controloc(пїЅeludac)

ja nebi smio ni primirisat alkohol. jeli tako?

JoпїЅ i pitaпїЅ.

Ne kortiпїЅi (medrol) i alkohol nisu baпїЅ najsretnija kombinacija. A i buduпїЅi da pijeпїЅ i controloc (pretpostavljam zbog medrola) nije ti pametno ni пїЅeludac optereпїЅivati, uz naravno veпїЅ optereпїЅenu jetru.

__________________ Ljubav je pobjeda maпїЅte nad inteligencijom. H. L. Menken . previпїЅe ljudi traпїЅi pravu osobu, umjesto da sami pokuпїЅaju biti prava osoba.

Matko, ne znam пїЅto su toпїЅno te tablete koje uzimaпїЅ, ali situacija je slijedeпїЅa: U svakom lijeku kojemu alkohol moпїЅe пїЅkoditi - takva informacija je NAPISANA! Dakle, ako u lijeku napisano da se ne smije piti uz njega, onda ti je svakako bolje drпїЅati se te preporuke. MeпїЅutim, ako u uputama tog lijeka NE piпїЅe da se alkohol ne smije uпїЅivati - u tom sluпїЅaju vrijedi ono: "пїЅto nije zabranjeno - dozvoljeno je!" InaпїЅe, znam da mnogo ljudi puno preuveliпїЅava moguпїЅu interakciju antibiotika s alkoholom. Ako pogledate u upute veпїЅine antibiotika, pa i onih penicilinskih, u njima neпїЅete naпїЅi napisano niпїЅta oko toga da se eventualno ne bi smio piti alkohol uz njih! I to zbog toga jer jednostavno jedno s drugim nema nikakve veze! DapaпїЅe, пїЅuo sam jednom na radiju u jednoj ozbiljnoj emisiji o zdravlju da alkoholna piпїЅa пїЅak pospjeпїЅuju adsorpciju antibiotika! Uz razne psihogene lijekove je doista opasno piti, jer moпїЅe doпїЅi do vrlo ozbiljnih, neugodnih, pa i opasnih interakcija, ali s antibioticima to stvarno NEMA veze. I da iznesem jedno svoje iskustvo: baпїЅ sam jednom kad sam iпїЅao na jednu veliku feпїЅtu bio bolestan i uzimao klavocin (penicilinski antibiotik). I tamo sam se prvo bojao bilo пїЅto popiti. Tamo je u druпїЅtvu bio jedan doktor, pa sam ga pitao za savjet i on se joпїЅ smijao da se ja bez veze bojim i da jedno s drugim nema veze. I tad sam se ohrabrio i popio sam to veпїЅe jedno tri пїЅaпїЅe vina i doista - baпїЅ mi NIпїЅTA nije naпїЅkodilo! Istina, nisam пїЅelio pretjerati ni puno popiti, ali to ni inaпїЅe ionako nije dobro ni pametno prema tome ako netko hoпїЅe popiti "пїЅaпїЅicu-dvije", a uzima antibiotik - to mu stvarno ne bi trebalo naпїЅkoditi niti predstavljati ikakav problem!

pazi gle. proпїЅitao sam za neke lijekove i nisam naпїЅao da je alkohol пїЅtetan, ali ja trenutno pijem 4 vrste lijekova pa me svejedno strah naget пїЅaпїЅicu. ALI zabava bi bila naveпїЅer a ja te lijekove pijem samo ujutro, osim virolexa kojeg moram 5 puta na dan..ali na njemu ne piпїЅe niпїЅta u vezi alkohola. jeli proпїЅlo dovoljno vremena od jutra do veпїЅeri, stim da bi se prvo najeo neпїЅega pa dalje. najviпїЅe me strah medrola kojeg ujutro pijem a kolega iznat je rekao da nije najsretnijja kombinacija

EDIT: alkohol inaпїЅe pijem samo u takvim posebnim prigodama, nikad ne pretjeram, ali ako nije sigurno raпїЅe пїЅu se suzdrпїЅat te veпїЅeri i piti juice

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If an attack occurs, use your quick-relief inhaler as prescribed. Qvar belongs to a class of drugs known as corticosteroids. Qvar does not work immediately and should not be prescribed to relieve an asthma attack. Qvar is prescribed for the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older. Qvar is prescribed regularly to prevent breathing problems (attacks of wheezing/shortness of breath). Qvar is prescribed to prevent and control symptoms (wheezing and shortness of breath) caused by asthma. Qvar works directly in the lungs to make breathing easier by reducing the irritation and swelling of the airways. Qvar-Inhaler is prescribed to treat asthma. This kind of condition is characterized by tightening of the breathing air passages caused by an inflammation or mucus accumulation. By reducing the risk of inflammation and the buildup of mucus, Qvar-Inhaler helps prevent asthma attacks. However, it is very important not to use the drug to treat an asthma attack which has already begun.

Side Effects

Qvar side effects that you should report to your health care professional or doctor as soon as possible: - Abad taste in the mouth; - Agitation; - Allergic reactions such as swelling of the lips; - Cough and hoarseness; - Depression; - Dry/sore throat; - Easy bruising/bleeding; - Headache; - Hoarseness; - Itching/swelling (especially of the face/tongue/throat); - Mental/mood changes; - Mood swings; - Muscle weakness/pain; - Narrowing of the breathing passages; - Puffy face; - Rash; - Severe dizziness; - Skin rash; - Slow wound healing; - Thinning skin; - Throat irritation; - Tongue or throat; - Trouble breathing; - Unusual hair growth; - Unusual tiredness; - Vision problems; - Voice changes; - Yeast infection of the oral cavity;

Contraindications

Qvar is contraindicated if you have any of the following conditions: - if you are allergic to Qvar; - if you have any other allergies; - if you have bleeding problems; - if you have bone loss (osteoporosis); - if you have current/past infections (tuberculosis, positive tuberculosis test, herpes, fungal); - if you have diabetes; - if you have eye disease (cataracts, glaucoma); - if you have liver disease; - if you have mental/mood conditions (psychosis, anxiety, depression); - if you have stomach/intestinal problems (diverticulitis, ulcer); - if you have thyroid problems;

Interactions

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Other Brand Names

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Clinical Studies

In a randomized, double-masked, multicenter clinical trial, Ocuflox ® ophthalmic solution was superior to its vehicle after 2 days of treatment in patients with conjunctivitis and positive conjunctival cultures. Clinical outcomes for the trial demonstrated a clinical improvement rate of 86% (54/63) for the ofloxacin treated group versus 72% (48/67) for the placebo treated group after 2 days of therapy. Microbiological outcomes for the same clinical trial demonstrated an eradication rate for causative pathogens of 65% (41/63) for the ofloxacin treated group versus 25% (17/67) for the vehicle treated group after 2 days of therapy. Please note that microbiologic eradication does not always correlate with clinical outcome in anti-infective trials.

In a randomized, double-masked, multi-center clinical trial of 140 subjects with positive cultures, Ocuflox ® ophthalmic solution treated subjects had an overall clinical success rate (complete re-epithelialization and no progression of the infiltrate for two consecutive visits) of 82% (61/74) compared to 80% (53/66) for the fortified antibiotic group, consisting of 1.5% tobramycin and 10% cefazolin solutions. The median time to clinical success was 11 days for the ofloxacin treated group and 10 days for the fortified treatment group.

INDICATIONS AND USAGE

Ocuflox ® ophthalmic solution is indicated for the treatment of infections caused by susceptible strains of the following bacteria in the conditions listed below:

CONTRAINDICATIONS

Ocuflox ® solution is contraindicated in patients with a history of hypersensitivity to ofloxacin, to other quinolones, or to any of the components in this medication.

WARNINGS

NOT FOR INJECTION.

Ocuflox ® solution should not be injected subconjunctivally, nor should it be introduced directly into the anterior chamber of the eye.

Serious and occasionally fatal hypersensitivity (anaphylactic) reactions, some following the first dose, have been reported in patients receiving systemic quinolones, including ofloxacin. Some reactions were accompanied by cardiovascular collapse, loss of consciousness, angioedema (including laryngeal, pharyngeal or facial edema), airway obstruction, dyspnea, urticaria, and itching. A rare occurrence of Stevens-Johnson syndrome, which progressed to toxic epidermal necrolysis, has been reported in a patient who was receiving topical ophthalmic ofloxacin. If an allergic reaction to ofloxacin occurs, discontinue the drug. Serious acute hypersensitivity reactions may require immediate emergency treatment. Oxygen and airway management, including intubation should be administered as clinically indicated.

PRECAUTIONS

General

As with other anti-infectives, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, fluorescein staining. Ofloxacin should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity reaction.

The systemic administration of quinolones, including ofloxacin, has led to lesions or erosions of the cartilage in weight-bearing joints and other signs of arthropathy in immature animals of various species. Ofloxacin, administered systemically at 10 mg/kg/day in young dogs (equivalent to 110 times the maximum recommended daily adult ophthalmic dose) has been associated with these types of effects.

Information for Patients

Avoid contaminating the applicator tip with material from the eye, fingers or other source.

Systemic quinolones, including ofloxacin, have been associated with hypersensitivity reactions, even following a single dose. Discontinue use immediately and contact your physician at the first sign of a rash or allergic reaction.

Drug Interactions

Specific drug interaction studies have not been conducted with Ocuflox ® ophthalmic solution. However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhance the effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long term studies to determine the carcinogenic potential of ofloxacin have not been conducted.

Ofloxacin was not mutagenic in the Ames test, in vitro and in vivo cytogenic assay, sister chromatid exchange assay (Chinese hamster and human cell lines), unscheduled DNA synthesis (UDS) assay using human fibroblasts, the dominant lethal assay, or mouse micronucleus assay. Ofloxacin was positive in the UDS test using rat hepatocyte, and in the mouse lymphoma assay.

In fertility studies in rats, ofloxacin did not affect male or female fertility or morphological or reproductive performance at oral dosing up to 360 mg/kg/day (equivalent to 4000 times the maximum recommended daily ophthalmic dose).

Pregnancy

Teratogenic Effects. Pregnancy Category C

Ofloxacin has been shown to have an embryocidal effect in rats and in rabbits when given in doses of 810 mg/kg/day (equivalent to 9000 times the maximum recommended daily ophthalmic dose) and 160 mg/kg/day (equivalent to 1800 times the maximum recommended daily ophthalmic dose). These dosages resulted in decreased fetal body weight and increased fetal mortality in rats and rabbits, respectively. Minor fetal skeletal variations were reported in rats receiving doses of 810 mg/kg/day. Ofloxacin has not been shown to be teratogenic at doses as high as 810 mg/kg/day and 160 mg/kg/day when administered to pregnant rats and rabbits, respectively.

Additional studies in rats with doses up to 360 mg/kg/day during late gestation showed no adverse effect on late fetal development, labor, delivery, lactation, neonatal viability, or growth of the newborn.

There are, however, no adequate and well-controlled studies in pregnant women. Ocuflox ® solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers

In nursing women a single 200 mg oral dose resulted in concentrations of ofloxacin in milk which were similar to those found in plasma. It is not known whether ofloxacin is excreted in human milk following topical ophthalmic administration. Because of the potential for serious adverse reactions from ofloxacin in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use

Safety and effectiveness in infants below the age of one year have not been established.

Quinolones, including ofloxacin, have been shown to cause arthropathy in immature animals after oral administration; however, topical ocular administration of ofloxacin to immature animals has not shown any arthropathy. There is no evidence that the ophthalmic dosage form of ofloxacin has any effect on weight bearing joints.

Geriatric Use

No overall differences in safety or effectiveness have been observed between elderly and younger patients.

Adverse Reactions

The most frequently reported drug-related adverse reaction was transient ocular burning or discomfort. Other reported reactions include stinging, redness, itching, chemical conjunctivitis/keratitis, ocular/periocular/facial edema, foreign body sensation, photophobia, blurred vision, tearing, dryness, and eye pain. Rare reports of dizziness and nausea have been received.

DOSAGE AND ADMINISTRATION

The recommended dosage regimen for the treatment of bacterial conjunctivitis is:



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AZELASTINE EYE DROPS

Transcript

Package Leaflet: Information for the patient

Azelastine 0.5 mg/ml Eye Drops, Solution Azelastine hydrochloride

Read all of this leaflet carefully before you start using this medicine because it contains important information for you. • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor or pharmacist. • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. • In this leaflet Azelastine 0.5 mg/ml Eye Drops, Solution is called Azelastine. What is in this leaflet 1. What Azelastine is and what it is used for 2. What you need to know before you use Azelastine 3. How to use Azelastine 4. Possible side effects 5. How to store Azelastine 6. Contents of the pack and other information. 1. What Azelastine is and what it is used for Azelastine contains the active substance azelastine hydrochloride, which belongs to a group of medicines called antiallergics (antihistamines). Antihistamines work by preventing the effects of substances such as histamine that the body produces as part of an allergic reaction. Azelastine has been shown to reduce inflammation of the eye. Azelastine can be used to treat and prevent eye disorders which you get with hayfever (seasonal allergic conjunctivitis) in adults and children aged 4 years and above.

- if you wear contact lenses. Children and adolescents For the treatment of eye disorders caused by hayfever (seasonal allergic conjunctivitis): Do not give this medicine to children below 4 years of age, because safety and efficacy have not been established. For the treatment of eye disorders caused by an allergy (non-seasonal (perennial) allergic conjunctivitis): Do not give this medicine to children below 12 years of age, because safety and efficacy have not been established. Other medicines and Azelastine Although Azelastine is not known to be affected by other medicines, tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

You must talk to a doctor if you do not feel better or if you feel worse after 2 days. Azelastine is not suitable for treating eye infections.

2. What you need to know before you use Azelastine Do not use Azelastine: • if you are allergic to azelastine hydrochloride or any of the other ingredients of this medicine (listed in section 6). Warnings and precautions Talk to your doctor or pharmacist before using Azelastine: - if you are not sure whether your eye disorders are caused by an allergy. In particular if only one eye is affected; if your vision is impaired; or the eye hurts and you do not have any symptoms in your nose, you may have an infection rather than an allergy - if the complaints worsen or last longer than 48 hours without remarkable improvement despite the use of Azelastine

provide more information on the safety of this medicine.

1. Wash your hands. 2. Gently wipe around your eyes with a tissues to remove any moisture (Diagram 1). 3. Unscrew the top of the bottle and check that the dropper is clean. 4. Gently pull your lower eye lid down (Diagram 2). 5. Carefully place the drop inside the middle of your lower eyelid (Diagram 3). Take care not to let the dropper touch your eye. 6. Release your lower eye lid and gently press on the inner corner of your eye against the bridge of your nose (Diagram 4). Keeping your finger pressed against your nose, slowly blink your eyes a few times to spread the drop across the surface of your eye. 7. Blot away any excess medicine with a tissue. 8. Repeat this for your other eye.

Keep this medicine out of the sight and reach of children.

Duration of treatment If possible, you should use Azelastine regularly until your symptoms have disappeared. Do not take Azelastine for more than 6 weeks.

Driving and using machines Your sight may become blurred for a short time after you use Azelastine. If this happens, wait until your sight clears before you drive or use machinery.

If you use more Azelastine than you should If you put too much Azelastine into your eyes you are unlikely to have any problems. If you are worried, contact your doctor. If you accidentally swallow Azelastine, contact your doctor or nearest hospital casualty department as soon as possible.

Azelastine contains benzalkonium chloride Azelastine contains the preservative benzalkonium chloride, which is known to discolour soft contact lenses. Avoid contact with soft contact lenses. Remove contact lenses prior to application and wait at least 15 minutes before reinsertion.

If you forget to use Azelastine Use your eye drops as soon as you remember, then take the next dose at the usual time. Do not take a double dose to make up for a missed dose.

Benzalkonium chloride may cause an allergic reaction (eye irritation).

Azelastine can be used for eye disorders caused by an allergy to substances such as house dust mites or animal hair (perennial allergic conjunctivitis) in adults and children aged 12 years and above.

Putting in your Azelastine eye drops To help you put in your eye drops correctly, you may find it useful to sit in front of a mirror so you can see what you are doing for the first few times.

Always use this medicine exactly as your doctor has told you. Check with your doctor if you are not sure. Remember: • Azelastine should only be applied to the eyes. The recommended dose is: Eye disorders caused by hayfever (seasonal allergic conjunctivitis) • Use in adults and children aged 4 years and above • The usual dose is one drop in each eye in the morning and evening.

6. Contents of the pack and other information What Azelastine contains The active substance is azelastine hydrochloride 0.05% (0.5 mg/ml). Each drop contains 0.015 mg azelastine hydrochloride. The other ingredients are benzalkonium chloride, disodium edetate, hypromellose, liquid sorbitol (crystallising) (E420i), sodium hydroxide (E524) and water for injections. What Azelastine looks like and contents of the pack Azelastine is a clear, colourless solution. Azelastine comes in a plastic bottle with a dropper attachment. One bottle contains either 6, 8 or 10 ml eye drops, solution. Not all pack sizes may be marketed. Marketing Authorisation Holder Meda Pharmaceuticals Limited Skyway House Parsonage Road Takeley Bishop’s Stortford CM22 6PU

4. Possible side effects

This medicinal product is authorised in the Member States of the EEA under the following names:

These effects include: • Common (may affect up to 1 in 10 people): Slight irritation (burning, itching, watering) in the eyes after putting in Azelastine. This should not last long. • Uncommon (may affect up to 1 in 100 people): A bitter taste in your mouth. This should quickly disappear especially if you have a soft drink. • Very rare (may affect up to 1 in 10,000 people): An allergic reaction (such as rash and itching).

Eye disorders caused by an allergy (non-seasonal (perennial) allergic conjunctivitis) • Use in adults and children aged 12 years and above • The usual dose is one drop in each eye in the morning and evening.

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Like all medicines, this medicine can cause side effects, although not everybody gets them.

If you anticipate contact with pollen, the usual dose of Azelastine may be taken as a preventive measure before going outside.

Do not use this medicine after the expiry date which is stated on the bottle label and the outer carton. The expiry date refers to the last day of that month. Once opened: Do not use this medicine if the bottle has been open for longer than 4 weeks. This medicine does not require any special storage conditions.

Manufacturer MEDA Pharma GmbH & Co. KG Benzstrasse 1 61352 Bad Homburg Germany Tel: +49 (0) 6172 888 - 01 fax: +49 (0) 6172 888 - 2740 e-mail: medinfo@medapharma. de

If you stop using Azelastine If you interrupt the use of Azelastine your symptoms are likely to return.

3. How to use Azelastine

5. How to store Azelastine

United Kingdom: Ireland: Italy: Austria, Denmark, Finland, Portugal, Sweden, The Netherlands: Spain: Germany:

Relief of symptoms of allergic conjunctivitis should be noticed after 15-30 minutes.

PRODUCT: Insert Azelastine (UK) MEASURE: 120 x 295 mm (120 x 25 mm) COLOURS:

EXTRA: Deca code

NOTE: www. effe5grafica. it Tel. (+39) 06 9326.0017 postmaster@effe5grafica. it

TEXT SIZE: 8 pt / Helvetica Family

Oculastin Corifina Allergodil akut Augentropfen Allergodil Augentropfen

This leaflet was last revised in June 2015.

Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard By reporting side effects you can help

If your symptoms are severe, your doctor may increase your dose to one drop in each eye, up to four times a day.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



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DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

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Sulfatrim Ds Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Alfatrim

Sulfatrim DS

Uses

This medication is a combination of two antibiotics. sulfamethoxazole and trimethoprim. It is used to treat a wide variety of bacterial infections (such as middle ear, urine, respiratory, and intestinal infections). It is also used to prevent and treat a certain type of pneumonia (pneumocystis-type).

This medication should not be used in children less than 2 months of age due to the risk of serious side effects.

This medication treats only certain types of infections. It will not work for viral infections (such as flu ). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

How to use Sulfatrim DS

Take this medication by mouth. as directed by your doctor, with a full glass of water (8 ounces / 240 milliliters). If stomach upset occurs, take with food or milk. Drink plenty of fluids while taking this medication to lower the unlikely risk of kidney stones forming, unless your doctor advises you otherwise. Dosage is based on your medical condition and response to treatment.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping it too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Tell your doctor if your condition persists or worsens.

Side Effects

Nausea. vomiting. diarrhea. and loss of appetite may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: muscle weakness. mental/mood changes, signs of kidney problems (such as change in the amount of urine, blood in the urine ), extreme drowsiness, signs of low blood sugar (such as nervousness, shakiness, sweating. hunger ).

Get medical help right away if you have any very serious side effects, including: persistent headache. neck stiffness, seizures. slow/irregular heartbeat .

This medication may rarely cause serious (possibly fatal) allergic reactions and other side effects such as a severe peeling skin rash (such as Stevens-Johnson syndrome), blood disorders (such as agranulocytosis. aplastic anemia ), liver damage, or lung injury. If you notice any of the following, get medical help right away: skin rash /blisters. itching /swelling (especially of the face/tongue /throat), persistent sore throat or fever, paleness, joint pain /aches, persistent cough. trouble breathing. easy bleeding/bruising, yellowing eyes or skin. persistent nausea/vomiting, unusual fatigue. dark urine.

This medication may rarely cause a severe intestinal condition (Clostridium difficile - associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain /cramping, blood /mucus in your stool.

Do not use anti-diarrhea products or narcotic pain medications if you have any of these symptoms because these products may make them worse.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth. a change in vaginal discharge. or other new symptoms.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking sulfamethoxazole with trimethoprim, tell your doctor or pharmacist if you are allergic to sulfa medications or trimethoprim; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, certain blood disorders (such as porphyria, anemia due to folate vitamin deficiency), history of blood disorders caused by trimethoprim or sulfa medications, vitamin deficiency (folate or folic acid), severe allergies, asthma, decreased bone marrow function (bone marrow suppression), a certain metabolic disorder (G6PD deficiency), underactive thyroid, mineral imbalances (such as high level of potassium or low level of sodium in the blood).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths or sunlamps. Use a sunscreen and wear protective clothing when outdoors.

If you have diabetes, this product may affect your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor right away if you have symptoms of low blood sugar (see Side Effects section). Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Older adults may be more sensitive to the side effects of this drug, especially skin reactions, blood disorders, easy bleeding/bruising, and a high potassium blood level.

Patients with AIDS may be more sensitive to the side effects of this drug, especially skin reactions, fever, and blood disorders.

This medication is not recommended for use during pregnancy especially near the expected delivery date because of possible harm to the unborn baby. Consult your doctor for more details.

This drug passes into breast milk. While there have been no reports of harm to healthy infants, this drug may have undesirable effects on infants who are ill or premature or have certain disorders (jaundice, high blood levels of bilirubin, G6PD deficiency). Therefore, breast-feeding is not recommended for infants with these conditions. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: "blood thinners" (such as warfarin), dofetilide, hydantoins (such as phenytoin), live vaccines, methenamine, methotrexate.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

This product may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this product.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe nausea/vomiting/diarrhea, severe dizziness or drowsiness, mental/mood changes.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in that case.

If taking this medication for an extended period, laboratory and/or medical tests (such as complete blood count, kidney function tests, potassium blood level, cultures) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Drugbank Mexiletine, Mobalen

For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.

Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Mexiletine has fast onset and offset kinetics, meaning that they have little or no effect at slower heart rates, and more effects at faster heart rates. It shortens the action potential duration, reduces refractoriness, and decreases Vmax in partially depolarized cells with fast response action potentials. Mexiletine either does not change the action potential duration, or decreases the action potential duration.

Mechanism of action

Mexiletine, like lidocaine, inhibits the inward sodium current required for the initiation and conduction of impulses, thus reducing the rate of rise of the action potential, Phase 0. It achieves this reduced sodium current by inhibiting sodium channels. Mexiletine decreases the effective refractory period (ERP) in Purkinje fibers in the heart. The decrease in ERP is of lesser magnitude than the decrease in action potential duration (APD), which results in an increase in the ERP/APD ratio. It does not significantly affect resting membrane potential or sinus node automaticity, left ventricular function, systolic arterial blood pressure, atrioventricular (AV) conduction velocity, or QRS or QT intervals

Targets

Kind Protein Organism Human Pharmacological action yes Actions inhibitor General Function: Voltage-gated sodium channel activity involved in sa node cell action potential Specific Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is respon. Gene Name: SCN5A Uniprot ID: Q14524 Molecular Weight: 226937.475 Da

References

Valdivia CR, Ackerman MJ, Tester DJ, Wada T, McCormack J, Ye B, Makielski JC: A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine. Cardiovasc Res. 2002 Aug 1;55(2):279-89. [PubMed:12123767 ]

Chinushi M, Tagawa M, Sugiura H, Komura S, Hosaka Y, Washizuka T, Aizawa Y: Ventricular tachyarrhythmias in a canine model of LQT3: arrhythmogenic effects of sympathetic activity and therapeutic effects of mexiletine. Circ J. 2003 Mar;67(3):263-8. [PubMed:12604879 ]

Fabritz L, Kirchhof P, Franz MR, Nuyens D, Rossenbacker T, Ottenhof A, Haverkamp W, Breithardt G, Carmeliet E, Carmeliet P: Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice. Cardiovasc Res. 2003 Mar 15;57(4):1085-93. [PubMed:12650887 ]

Wang HW, Zheng YQ, Yang ZF, Li CZ, Liu YM: Effect of mexiletine on long QT syndrome model. Acta Pharmacol Sin. 2003 Apr;24(4):316-20. [PubMed:12676070 ]

Napolitano C, Bloise R, Priori SG: Gene-specific therapy for inherited arrhythmogenic diseases. Pharmacol Ther. 2006 Apr;110(1):1-13. Epub 2005 Sep 15. [PubMed:16168489 ]

Shimizu W, Antzelevitch C, Suyama K, Kurita T, Taguchi A, Aihara N, Takaki H, Sunagawa K, Kamakura S: Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec;11(12):1320-9. [PubMed:11196553 ]

Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Kind Protein Organism Human Pharmacological action unknown Actions agonist General Function: Transcription regulatory region dna binding Specific Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and matu. Gene Name: AHR Uniprot ID: P35869 Molecular Weight: 96146.705 Da

References

Hu W, Sorrentino C, Denison MS, Kolaja K, Fielden MR: Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Mol Pharmacol. 2007 Jun;71(6):1475-86. Epub 2007 Feb 27. [PubMed:17327465 ]

Enzymes

Kind Protein Organism Human Pharmacological action unknown Actions substrate inhibitor General Function: Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Specific Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N. Gene Name: CYP1A2 Uniprot ID: P05177 Molecular Weight: 58293.76 Da

References

Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Nakajima M, Kobayashi K, Shimada N, Tokudome S, Yamamoto T, Kuroiwa Y: Involvement of CYP1A2 in mexiletine metabolism. Br J Clin Pharmacol. 1998 Jul;46(1):55-62. [PubMed:9690950 ]

Drug Interactions: Cytochrome P450 Drug Interaction Table [Link ]

Kind Protein Organism Human Pharmacological action unknown Actions substrate General Function: Steroid hydroxylase activity Specific Function: Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. Gene Name: CYP2D6 Uniprot ID: P10635 Molecular Weight: 55768.94 Da

References

Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Nakajima M, Kobayashi K, Shimada N, Tokudome S, Yamamoto T, Kuroiwa Y: Involvement of CYP1A2 in mexiletine metabolism. Br J Clin Pharmacol. 1998 Jul;46(1):55-62. [PubMed:9690950 ]

Drug Interactions: Cytochrome P450 Drug Interaction Table [Link ]

Kind Protein Organism Human Pharmacological action unknown Actions substrate General Function: Steroid hydroxylase activity Specific Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. Gene Name: CYP2B6 Uniprot ID: P20813 Molecular Weight: 56277.81 Da

References

Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Kind Protein Organism Human Pharmacological action unknown Actions substrate General Function: Steroid hydroxylase activity Specific Function: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms. Gene Name: CYP2E1 Uniprot ID: P05181 Molecular Weight: 56848.42 Da

References

Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Kind Protein Organism Human Pharmacological action unknown Actions substrate General Function: Vitamin d3 25-hydroxylase activity Specific Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e. g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot. Gene Name: CYP3A4 Uniprot ID: P08684 Molecular Weight: 57342.67 Da

References

Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions. and by The Metabolomics Innovation Centre (TMIC). a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta. Genome British Columbia. and Genome Canada. a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc.



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surpass

1. To do more than or be superior to: surpassed her classmates in academic honors. See Synonyms at excel .

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To do the best that one ever has done at a given activity.

[French surpasser . from Old French, to transgress . sur - . sur - + passer . pass ; see pass .]

surpass

1. to be greater than in degree, extent, etc

2. to be superior to in achievement or excellence

3. to overstep the limit or range of: the theory surpasses my comprehension.

[C16: from French surpasser, from sur - 1 + passer to pass]

sur•pass

1. to go beyond in amount, extent, or degree; be greater than; exceed.

2. to go beyond in excellence or achievement; be superior to; excel.

3. to be beyond the range or capacity of; transcend: misery that surpasses description.

[1545–55; < Middle French surpasser = sur - sur - 1 + passer to pass ]

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I have a few treasures there that photography is not likely to surpass for some time yet.

She tried to surpass all that she had done till then; and she succeeded.

Thus also, those ancient cities which, from being at first only villages, have become, in course of time, large towns, are usually but ill laid out compared with the regularity constructed towns which a professional architect has freely planned on an open plain; so that although the several buildings of the former may often equal or surpass in beauty those of the latter, yet when one observes their indiscriminate juxtaposition, there a large one and here a small, and the consequent crookedness and irregularity of the streets, one is disposed to allege that chance rather than any human will guided by reason must have led to such an arrangement.

He strove to collect a band of followers, and followed the footsteps of Decesaris and Gasperone, whom he hoped to surpass .

So he at once said, "Aldermen and town councillors of the Phaeacians, we have had enough now, both of the feast, and of the minstrelsy that is its due accompaniment; let us proceed therefore to the athletic sports, so that our guest on his return home may be able to tell his friends how much we surpass all other nations as boxers, wrestlers, jumpers, and runners.

They came prancing along in gallant style, with many wild and dexterous evolutions, for none can surpass them in horsemanship; and their bright colors, and flaunting and fantastic embellishments, glaring and sparkling in the morning sunshine, gave them really a striking appearance.

Two persons whose desires are moderate may live well enough in Brussels on an income which would scarcely afford a respectable maintenance for one in London: and that, not because the necessaries of life are so much dearer in the latter capital, or taxes so much higher than in the former, but because the English surpass in folly all the nations on God's earth, and are more abject slaves to custom, to opinion, to the desire to keep up a certain appearance, than the Italians are to priestcraft, the French to vain-glory, the Russians to their Czar, or the Germans to black beer.



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Betnovate (Corsaderm)

Betnovate is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid (cortisone-like medicine or steroid).

Use Betnovate as directed by your doctor.

Betnovate is for use on the skin only. Do not get it in your eyes.

Wash your hands with soap and water before and after using this medicine.

Apply a thin layer of this medicine to the affected area of the skin. Rub it in gently.

Do not use cosmetics or other skin care products on the treated areas.

Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.

If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.

If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems.

If you miss a dose of Betnovate, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For redness, itching, and swelling of the skin:

Adults: Apply to the affected area of the skin one to three times per day.

Children: Use and dose must be determined by your doctor.

Ask your health care provider any questions you may have about how to use Betnovate.

Store Betnovate at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Betnovate out of the reach of children and away from pets.

Active Ingredient: Betamethasone.

Do NOT use Betnovate if:

you are allergic to any ingredient in Betnovate

you are taking mifepristone

you have a systemic fungal infection

you are scheduled to have a smallpox vaccine

you have a certain bleeding disorder (idiopathic thrombocytopenic purpura).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Betnovate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of bleeding problems, heart problems (eg, congestive heart failure [CHF]), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, any mental or mood problems, or low blood potassium levels

if you have or have recently had a bacterial, fungal, malarial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; shingles; or a head or brain injury

if you have HIV infection or tuberculosis (TB), or if you have ever had a positive TB skin test

if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, infection, unexplained diarrhea, diverticulitis, ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus

if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)

if you have had any recent vaccinations (eg, smallpox)

if you have a history of joint surgery or any joint problems (eg, fracture, infection).

Some medicines may interact with Betnovate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aprepitant, clarithromycin, cyclosporine, diltiazem, erythromycin, itraconazole, ketoconazole, or troleandomycin because side effects, such as adrenal gland or nervous system problems (eg, seizures), may occur

Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), lithium, or rifampin because they may decrease Betnovate's effectiveness

Aspirin, live vaccines, mifepristone, or ritodrine because the risk of their side effects may be increased by Betnovate.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Betnovate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Betnovate may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

Tell your doctor or dentist that you take Betnovate before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Betnovate may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If you use Betnovate for an extended period of time, your body may not produce enough natural steroids for up to several months after you stop using it. Severe symptoms may occur if you experience injury, surgery, infection, or loss of blood electrolytes. Contact your doctor immediately if you experience any of these events. You may need to begin taking additional corticosteroids.

If you have had Betnovate injected into a joint and you experience increased pain along with swelling, decreased joint movement, fever, and general feeling of being unwell, contact your doctor.

Talk with your doctor before you receive any vaccine while you are using Betnovate.

Lab tests, including adrenal function tests and blood pressure monitoring, may be performed while you use Betnovate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Betnovate may have benzyl alcohol in it. Do not use it in newborns or infants. It may cause serious and sometimes fatal nervous system problems and other side effects.

Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Betnovate.

Betnovate should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Betnovate while you are pregnant. Betnovate is found in breast milk. If you are or will be breast-feeding while you use Betnovate, check with your doctor. Discuss any possible risks to your baby.

If you suddenly stop taking Betnovate, you may have withdrawal symptoms, These may include unbalanced hormones (in both men and women).

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; clumsiness; dizziness; facial flushing; general body discomfort; headache; increased appetite; increased sweating; lightheadedness; nausea; nervousness; sleeplessness; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual periods; changes in skin color; chest pain; easy bruising or bleeding; irregular heartbeat; mental or mood changes (eg, depression); muscle pain, wasting, or weakness; seizures; severe nausea or vomiting; sudden severe dizziness or headache; swelling of feet or legs; symptoms of infection (eg, chills, fever, sore throat); tendon or bone pain; thinning of the skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Valeclor, Valeclor

Cefaclor

Chemical Name

5-tia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(aminophenylacetyl)amino]-3-chloro-8-oxo-, [6R-[6?,7?(R*)]]-

Foreign Names

Cefaclorum (Latin)

Cefaclor (German)

Cefaclor (French)

Cefaclor (Spanish)

Generic Names

Cefaclor (OS: USAN, JAN, BAN)

Cefacloro (OS: DCIT)

Cefeaclor (OS: DCF)

Cephaclor (IS)

Compound 99638 (IS: Lilly)

Cefaclor (PH: JP XVI, USP 38)

Cephaclor-1-Wasser (IS)

S 6472 (IS)

Cefaclor (PH: BP 2016, Ph. Eur. 8, USP 38)

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Cefaclor-Monohydrat (PH: Ph. Eur. 8)

Cefaclorum (PH: Ph. Eur. 8)

Brand Names



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Redomex Generic Name Amitriptyline Online, Redomex

Redomex General Information

Redomex - Pharmacology:

Redomex is metabolized to nortriptyline which inhibits the reuptake of norepinephrine and serotonin almost equally. Redomex inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. Pharmacologically this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating transmitting activity. This interference with the reuptake of norepinephrine and/or serotonin is believed by some to underlie the antidepressant activity of amitriptyline.

Redomex for patients

While on therapy with amitriptyline HCl, patients should be advised as to the possible impairment of mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle.

This description is suitable for active ingredient Amitriptyline

Redomex Interactions

Drugs Metabolized by P450 2D6 - The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7-10% of caucasians are so called "poor metabolizers"); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA).

In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble poor metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the coadministration of TCAs with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary).

Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from co-therapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be coadministered with another drug known to be an inhibitor of P450 2D6.

Monoamine Oxidase Inhibitors: Guanethidine or similarly acting compounds; thyroid medication; alcohol, barbiturates and other CNS depressants; and disulfiram

When amitriptyline HCl is given with anticholinergic agents or sympathomimetic drugs, including epinephrine combined with local anesthetics, close supervision and careful adjustment of dosages are required.

Hyperpyrexia has been reported when amitriptyline HCl is administered with anticholinergic agents or with neuroleptic drugs, particularly during hot weather.

Paralytic ileus may occur in patients taking tricyclic antidepressants in combination with anticholinergic-type drugs.

Cimetidine is reported to reduce hepatic metabolism of certain tricyclic antidepressants, thereby delaying elimination and increasing steady-state concentrations of these drugs. Clinically significant effects have been reported with the tricyclic antidepressants when used concomitantly with cimetidine. Increases in plasma levels of tricyclic antidepressants, and in the frequency and severity of side effects, particularly anticholinergic, have been reported when cimetidine was added to the drug regimen. Discontinuation of cimetidine in well-controlled patients receiving tricyclic antidepressants and cimetidine may decrease the plasma levels and efficacy of the antidepressants.

Caution is advised if patients receive large doses of ethchlorvynol concurrently. Transient delirium has been reported in patients who were treated with one gram of ethchlorvynol and 75 - 150 mg of amitriptyline HCl.

Redomex Contraindications

Redomex HCl is contraindicated in patients who have shown prior hypersensitivity to it.

It should not be given concomitantly with monoamine oxidase inhibitors. Hyperpyretic crises, severe convulsions, and deaths have occurred in patients receiving tricyclic antidepressant and monoamine oxidase inhibiting drugs simultaneously. When it is desired to replace a monoamine oxidase inhibitor with amitriptyline HCl, a minimum of 14 days should be allowed to elapse after the former is discontinued. Redomex HCl should then be initiated cautiously with gradual increase in dosage until optimum response is achieved.

This drug is not recommended for use during the acute recovery phase following myocardial infarction.

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Lisinopril Medlineplus Drug Information, Linipril

Lisinopril

Lisinopril is used alone or in combination with other medications to treat high blood pressure. It is used in combination with other medications to treat heart failure. Lisinopril is also used to improve survival after a heart attack. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

How should this medicine be used?

Lisinopril comes as a tablet to take by mouth. It is usually taken once a day. To help you remember to take lisinopril, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lisinopril exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of lisinopril and gradually increase your dose.

Lisinopril controls high blood pressure and heart failure but does not cure them. Continue to take lisinopril even if you feel well. Do not stop taking lisinopril without talking to your doctor.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking lisinopril,

tell your doctor and pharmacist if you are allergic to lisinopril; other ACE inhibitors such as enalapril (Vasotec, in Vaseretic), benazepril (Lotensin, in Lotrel), captopril (Capoten), fosinopril (Monopril), moexipril (Univasc, in Uniretic), perindopril (Aceon), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); any other medications; or any ingredients in lisinopril tablets. Ask your pharmacist for a list of the ingredients.

tell your doctor if you have diabetes and you are taking aliskiren (Tekturna, in Amturnide, Tekamlo, Tekturna HCT). Your doctor will probably tell you not to take lisinopril if you have diabetes and you are also taking aliskiren.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin (Indocin, Tivorbex); diuretics ('water pills'); lithium (Lithobid); and potassium supplements. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you have or have ever had heart or kidney disease; diabetes; lupus; scleroderma (a condition in which extra tissue grows on the skin and some organs); or angioedema (a condition that causes difficulty swallowing or breathing and painful swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs).

tell your doctor if you are breastfeeding.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking lisinopril.

you should know that diarrhea, vomiting, not drinking enough fluids, and sweating a lot can cause a drop in blood pressure, which may cause lightheadedness and fainting.

What special dietary instructions should I follow?

Talk to your doctor before using salt substitutes containing potassium. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Lisinopril may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

cough

dizziness

headache

excessive tiredness

nausea

diarrhea

weakness

sneezing

runny nose

decrease in sexual ability

rash

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

hoarseness

difficulty breathing or swallowing

fever, sore throat, chills, and other signs of infection

yellowing of the skin or eyes

lightheadedness

fainting

chest pain

Lisinopril may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include the following:



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Limbitrol (Chlordiazepoxide Amitriptyline Ds Tablets) Drug Information Indications, Dosage And How S

INDICATIONS

LIMBITROL is indicated for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.

The therapeutic response to LIMBITROL occurs earlier and with fewer treatment failures than when either amitriptyline or chlordiazepoxide is used alone.

Symptoms likely to respond in the first week of treatment include: insomnia, feelings of guilt or worthlessness, agitation, psychic and somatic anxiety, suicidal ideation and anorexia .

DOSAGE AND ADMINISTRATION

Optimum dosage varies with the severity of the symptoms and the response of the individual patient. When a satisfactory response is obtained, dosage should be reduced to the smallest amount needed to maintain the remission. The larger portion of the total daily dose may be taken at bedtime. In some patients, a single dose at bedtime may be sufficient. In general, lower dosages are recommended for elderly patients.

LIMBITROL DS (double strength) Tablets are recommended in an initial dosage of 3 or 4 tablets daily in divided doses; this may be increased to 6 tablets daily as required. Some patients respond to smaller doses and can be maintained on 2 tablets daily.

LIMBITROL Tablets in an initial dosage of 3 or 4 tablets daily in divided doses may be satisfactory in patients who do not tolerate higher doses.

HOW SUPPLIED

LIMBITROL DS (double strength) Tablets are available as white, film-coated, biconvex tablets containing 10 mg chlordiazepoxide and 25 mg amitriptyline (as the hydrochloride salt) in bottles of 100 ( NDC 0187-3806-10). Each tablet is engraved “V 3806” on one side.

LIMBITROL Tablets are available as blue, film-coated, biconvex tablets containing 5 mg chlordiazepoxide and 12.5 mg amitriptyline (as the hydrochloride salt) in bottles of 100 ( NDC 0187-3805-10). Each tablet is engraved “V 3805” on one side.

Store at 25°C (77°F); excursions permitted to 15°C – 30°C (59°F – 86°F). Store in a dry place.

Manufactured for: Heritage Pharmaceuticals Inc. Eatontown, NJ 07724 1.866.901. Revised: Apr 2016

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 5/5/2016



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Infliximab, Remicade Side Effects & Dosing, Remicard

infliximab, Remicade

BRAND NAME: Remicade

GENERIC AVAILABLE: No

USES: Infliximab is approved for use alone or combined with methotrexate (Rheumatrex. Trexall ) for treating moderate to severe rheumatoid arthritis.

Infliximab is used for reducing the signs and symptoms of inflammation in moderate to severe Crohn's disease and Crohn's disease in which there are fistulas (passageways created when the inflammation penetrates beyond the wall of the intestine).

It also has been found to be helpful in treating the inflammation of uveitis and sarcoidosis that is not responding to traditional therapies.

Infliximab is approved for use in pediatric patients with moderately to severely active Crohn's disease who have had an inadequate response to conventional therapy.

SIDE EFFECTS: The most common side effects of infliximab include:

Other important side effects include:

Reactions listed above could indicate an allergy to the infliximab. They are more common among patients who develop antibodies to infliximab and are less likely to occur in patients who are taking drugs that suppress the immune system. such as methotrexate.

Infliximab should be discontinued if serious reactions occur. Serious infections have been reported with other drugs that block TNF - alpha, and infections have been reported during treatment with infliximab. Therefore, infliximab should not be used in patients with serious infections. Moreover, infliximab should be discontinued if a serious infection develops during treatment. Testing for tuberculosis (PPD tests for TB ) should be doneprior to treatment with infliximab because of reports of reactivation of tuberculosis in patients taking infliximab. Such patients should be treated for tuberculosis.

Decreased white and red blood cell and decreased platelet counts have been reported with infliximab. Vasculitis (inflammation of the arteries) also has been reported.

Patients with Crohn's disease or rheumatoid arthritis. particularly patients with highly active disease and/or chronic exposure to immunosuppressant therapies, may be at a higher risk (up to several fold) than the general population for the development of malignant lymphoma. More malignancies have been observed in open-label, uncontrolled clinical studies at a rate several-fold higher than expected in the general population. In controlled studies of TNF-alpha blocking agents, including infliximab, more cases of lymphoma and other malignancies have been observed among patients receiving the agents than among control group patients.

Medically Reviewed by a Doctor on 6/30/2016

Quick Guide Rheumatoid Arthritis Symptoms and Treatment

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.



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