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Dexacort Phosphate In Turbinaire Medical Facts From, Dexacort

Dexacort Phosphate in Turbinaire

Dexamethasone nasal was withdrawn from the U. S. market in 1998.

Dexamethasone is a steroid. It prevents the release of substances in the body that cause inflammation.

Dexamethasone nasal is used to treat the nasal symptoms of allergies and other seasonal reactions.

Dexamethasone nasal is also used to treat some types of nasal polyps.

Dexamethasone nasal may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Dexacort Phosphate in Turbinaire (dexamethasone nasal)?

Dexamethasone nasal was withdrawn from the U. S. market in 1998.

Do not use more of this medication than is prescribed for you. Too much may cause serious side effects.

Use dexamethasone nasal on a regular basis for best results. It may take several weeks to get the maximum effect of this medication.

Who should not use Dexacort Phosphate in Turbinaire (dexamethasone nasal)?

Before taking this medication, tell your doctor if you have a viral, bacterial, or fungal infection of any kind. The absorption of this drug into your system can inhibit your body's ability to fight off infections. You may not be able to use dexamethasone nasal if you have an infection.

Dexamethasone nasal is in the FDA pregnancy category C. This means that it is not known whether dexamethasone nasal will harm an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant.

Dexamethasone passes into breast milk and may harm a nursing baby. Do not use dexamethasone nasal without first talking to your doctor if you are breast-feeding a baby.

Dexamethasone nasal is not approved for use in children younger than 6 years of age.

How should I use Dexacort Phosphate in Turbinaire (dexamethasone nasal)?

Use dexamethasone nasal spray exactly as directed by your doctor. Read the information insert included with your medication. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Shake the medication well before each dose.

If your nose is congested, try to clear it before using your medication to be sure that the medicine gets into your nasal passages. If you are also using a decongestant spray, use it to open up your nasal passages before using dexamethasone. However, do not use a decongestant spray unless your doctor approves.

Do not use more of this medication than is prescribed for you. Never use more than 12 sprays (1,008 micrograms) per day. It may take a few weeks to see the effects of dexamethasone nasal. Talk to your doctor if your symptoms do not improve or if they get worse.

Store dexamethasone nasal at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and use the next one as directed. Do not use a double dose of this medication.

What happens if I overdose?

An overdose of this medication is not likely to occur. If you do think that an overdose has occurred, call an emergency room or poison control center .

What should I avoid while using Dexacort Phosphate in Turbinaire (dexamethasone nasal)?

Avoid items or activities that you know are allergens for you if they make your symptoms worse. Clean areas where dust or pet fur may aggravate your condition.

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Dexacort Phosphate in Turbinaire (dexamethasone nasal) side effects

Serious side effects from dexamethasone nasal are not likely to occur. Stop using dexamethasone nasal and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

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stinging or burning of the nose;

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Hotel Playa Cambutal (Panama) - 2016 Hotel Reviews, Combutol

I am originally from Panama, and my mom is from this area of the country (Azuero). I had heard many nice things of this hotel and wanted to treat my mom, cousin and his wife to a few days away, and of course myself. The rooms were reasonably priced and the hotel didn't disappoint. The staff made it even better. Breakfast was included and the beach is just right in front of you. This was one of the best holidays i have had in a long time and my family enjoyed it as well.

“ Beautiful beachfront boutique hotel ”

Maite B (12 reviews)

Panama City, Panama

I went with friends to spend the end of eater week and our main goal was to relax as much as possible and I have to say: Mission accomlished. This hotel was what we need it. In front of the beach, with and amazing pool and porch to relax and watch the sunset and a super friendly staff.

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Diclofenac - Woman S Health, Sorelmon

Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis. Diclofenac may also be used for purposes other than those listed in this medication guide.

Use Diclofenac as directed by your doctor.

Take Diclofenac by mouth with or without food. Ask your health care provider any questions you may have about how to use Diclofenac.

Drug Class and Mechanism

Diclofenac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

If you miss a dose of Diclofenac, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Store Diclofenac at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do not use Diclofenac if:

you are allergic to any ingredient in Diclofenac; you have had a severe allergic reaction (e. g. severe rash, hives, breathing difficulties, dizziness) to another NSAID (e. g. ibuprofen, naproxen, celecoxib) or aspirin. Contact your doctor or health care provider right away if any of these apply to you.

Important : Diclofenac may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Before you start any new medicine, check the label to see if it has Sorelmon or another nonsteroidal anti-inflammatory drug (NSAID) medicine in it too. If it does or if you are not sure, check with your doctor or pharmacist. Diclofenac should not be used in children; safety and effectiveness in children have not been confirmed. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breast-feed while using Diclofenac.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

burning or stinging; discharge; eye redness, irritation, or itching. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred or distorted vision; eye infection; eyelid swelling or redness; sensitivity to glare or light.

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Anti Fungal - Vagiclot (Brand name: mycelex-g)

Mycelex-G (Clotrimazole) is an antifungal medication. It prevents fungus from growing.

Clotrimazole vaginal is used to treat vaginal candida (yeast) infections.

Clotrimazole vaginal may also be used for purposes other than those listed in this medication guide.

Use Mycelex-G exactly as directed by your doctor, or follow the directions that accompany the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using this medication.

Insert the tablet, suppository, or cream into the vagina using the applicator as directed.

Use this medication continuously for the prescribed amount of time, even during your menstrual period.

You can use a sanitary napkin to prevent the medication from staining your clothing but do not use a tampon.

If the infection does not clear up after you have finished one course of therapy, or if it appears to get worse, see your doctor. You may have another type of infection.

Avoid getting this medication in your eyes, nose, or mouth. Store clotrimazole vaginal at room temperature away from moisture and heat.

Active ingredient: Clotrimazole

Clotrimazole is an antifungal medication. It prevents fungus from growing.

Clotrimazole vaginal is used to treat vaginal candida (yeast) infections.

It also may be used for purposes other than those listed in this medication guide.

Do not use clotrimazole vaginal if you have ever had an allergic reaction to it.

If this is the first time that you have ever had symptoms of a vaginal yeast infection, consult your doctor before using this medication.

Do not use clotrimazole vaginal if you have a fever, abdominal pain, foul-smelling discharge, diabetes, HIV, or AIDS. Consult your doctor. Do not use this medication without first talking to your doctor if you are pregnant. Do not use clotrimazole vaginal without first talking to your doctor if you are breast-feeding a baby. Do not use this medication if you are younger than 12 years of age.

Important safety information

Use this medication for the full amount of time prescribed by your doctor or recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.

Avoid wearing tight-fitting, synthetic clothing (e. g. panty hose) that does not allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed. Avoid getting this medication in your eyes, nose, or mouth.

Stop using clotrimazole vaginal and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

Other, less serious side effects may be more likely to occur. These include burning, itching, irritation of the skin, and an increased need to urinate.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Avoid using other vaginal creams or douches at the same time as clotrimazole unless your doctor approves.

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Paracetamol Side Effects In Detail, Revanin

Paracetamol Side Effects

Note: This page contains side effects data for the generic drug acetaminophen. It is possible that some of the dosage forms included below may not apply to the brand name Paracetamol.

For the Consumer

Applies to acetaminophen: capsule, capsule liquid filled, elixir, liquid, powder, powder for solution, solution, suppository, suspension, syrup, tablet, tablet chewable, tablet disintegrating, tablet effervescent, tablet extended release

Other dosage forms:

As well as its needed effects, acetaminophen (the active ingredient contained in Paracetamol) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking acetaminophen, check with your doctor immediately:

Rare

Bloody or black, tarry stools

bloody or cloudy urine

fever with or without chills (not present before treatment and not caused by the condition being treated)

pain in the lower back and/or side (severe and/or sharp)

pinpoint red spots on the skin

skin rash, hives, or itching

sore throat (not present before treatment and not caused by the condition being treated)

sores, ulcers, or white spots on the lips or in the mouth

sudden decrease in the amount of urine

unusual bleeding or bruising

unusual tiredness or weakness

yellow eyes or skin

If any of the following symptoms of overdose occur while taking acetaminophen, get emergency help immediately:

Symptoms of overdose:

Diarrhea

increased sweating

loss of appetite

nausea or vomiting

stomach cramps or pain

swelling, pain, or tenderness in the upper abdomen or stomach area

For Healthcare Professionals

Applies to acetaminophen: compounding powder, intravenous solution, oral capsule, oral granule effervescent, oral liquid, oral powder for reconstitution, oral suspension, oral tablet, oral tablet chewable, oral tablet disintegrating, oral tablet extended release, rectal suppository

General

In general, acetaminophen (the active ingredient contained in Paracetamol) is well-tolerated when administered in therapeutic doses. The most commonly reported adverse reactions have included nausea, vomiting, constipation. Injection site pain and injection site reaction have been reported with the IV product. [Ref ]

Hepatic

Common (1% to 10%): Increased aspartate aminotransferase Rare (less than 0.1%): Increased hepatic transaminases Frequency not reported: Liver failure [Ref ]

Gastrointestinal

Very common (10% or more): Nausea (up to 34%), Vomiting (up to 15%) Common (1% to 10%): Abdominal pain, diarrhea, constipation, dyspepsia, enlarged abdomen Frequency not reported: Dry mouth [Ref ]

Hypersensitivity

Postmarketing reports: Anaphylaxis, hypersensitivity reactions [Ref ]

Hematologic

Common (1% to 10%): Anemia, postoperative hemorrhage Very rare (less than 0.01%): Thrombocytopenia, leucopenia, neutropenia [Ref ]

Dermatologic

Common (1% to 10%): Rash, pruritus Rare (less than 0.1%): Serious skin reactions such as acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, and toxic epidermal necrolysis Very rare (less than 0.01%): Pemphigoid reaction, pustular rash, Lyell syndrome : [Ref ]

Respiratory

Common (1% to 10%): Dyspnea, abnormal breath sounds, pulmonary edema, hypoxia, pleural effusion, stridor, wheezing, coughing [Ref ]

Cardiovascular

Common (1% to 10%): Peripheral edema, hypertension, hypotension, tachycardia, chest pain [Ref ]

Metabolic

Common (1% to 10%): Hypokalemia, hyperglycemia [Ref ]

Nervous system

Common (1% to 10%): Headache, dizziness Frequency not reported: Dystonia

Musculoskeletal

Common (1% to 10%): Muscle spasms, trismus

Psychiatric

Common (1% to 10%): Insomnia, anxiety

Genitourinary

Common (1% to 10%): Oliguria

Local

Common (1% to 10%): Infusion site pain, injection site reactions

Ocular

Common (1% to 10%): Periorbital edema

Other

Common (1% to 10%): Pyrexia, fatigue Rare (0.01% to 0.1%): Malaise

References

1. "Multum Information Services, Inc. Expert Review Panel"

2. Zimmerman HJ, Maddrey WC "Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure." Hepatology 22 (1995): 767-73

3. Vitols S "Paracetamol hepatotoxicity at therapeutic doses." J Intern Med 253 (2003): 95-8

4. Gursoy M, Haznedaroglu IC, Celik I, Sayinalp N, Ozcebe OI, Dundar SV "Agranulocytosis, plasmacytosis, and thrombocytosis followed by a leukemoid reaction due to acute acetaminophen toxicity." Ann Pharmacother 30 (1996): 762-5

5. Kurtovic J, Riordan SM "Paracetamol-induced hepatotoxicity at recommended dosage." J Intern Med 253 (2003): 240-3

6. Cheung L, Meyer KC "Acetaminophen poisoning and liver function." N Engl J Med 331 (1994): 1311-2

7. McJunkin B, Barwick KW, Little WC, Winfield JB "Fatal massive hepatic necrosis following acetaminophen overdose." JAMA 236 (1976): 1874-5

8. Rumore MM, Blaiklock RG "Influence of age-dependent pharmacokinetics and metabolism on acetaminophen hepatotoxicity." J Pharm Sci 81 (1992): 203-7

9. Kumar S, Rex DK "Failure of physicians to recognize acetaminophen hepatotoxicity in chronic alcoholics." Arch Intern Med 151 (1991): 1189-91

10. Minton NA, Henry JA, Frankel RJ "Fatal paracetamol poisoning in an epileptic." Hum Toxicol 7 (1988): 33-4

11. Whitcomb DC, Block GD "Association of acetaminopphen hepatotoxicity with fasting and ethanol use." JAMA 272 (1994): 1845-50

12. Block R, Jankowski JA, Lacoux P, Pennington CR "Does hypothermia protect against the development of hepatitis in paracetamol overdose?" Anaesthesia 47 (1992): 789-91

13. Hartleb M "Do thyroid hormones promote hepatotoxicity to acetaminophen?" Am J Gastroenterol 89 (1994): 1269-70

14. Lee WM "Acute liver failure." Am J Med 96 (1994): 3-9

15. Singer AJ, Carracio TR, Mofenson HC "The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction." Ann Emerg Med 26 (1995): 49-53

16. Kaysen GA, Pond SM, Roper MH, Menke DJ, Marrama MA "Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen." Arch Intern Med 145 (1985): 2019-23

17. Bonkovsky HL "Acetaminophen hepatotoxicity, fasting, and ethanol." JAMA 274 (1995): 301

18. Mofenson HC, Caraccio TR, Nawaz H, Steckler G "Acetaminophen induced pancreatitis." Clin Toxicol 29 (1991): 223-30

19. Keays R, Harrison PM, Wendon JA, et al "Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial." BMJ 303 (1991): 1026-9

20. Brotodihardjo AE, Batey RG, Farrell GC, Byth K "Hepatotoxicity from paracetamol self-poisoning in Western Sydney: a continuing challenge." Med J Aust 157 (1992): 382-5

21. Keaton MR "Acute renal failure in an alcoholic during therapeutic acetaminophen ingestion." South Med J 81 (1988): 1163-6

22. Lee WM "Medical progress: drug-induced hepatotoxicity." N Engl J Med 333 (1995): 1118-27

23. Johnson GK, Tolman KG "Chronic liver disease and acetaminophen." Ann Intern Med 87 (1977): 302-4

24. Smilkstein MJ, Douglas Dr, Daya MR "Acetaminophen poisoning and liver function." N Engl J Med 331 (1994): 1310-1

25. Shriner K, Goetz MB "Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine." Am J Med 93 (1992): 94-6

26. Cheung L, Potts RG, Meyer KC "Acetaminophen treatment nomogram." N Engl J Med 330 (1994): 1907-8

27. Whitcomb DC "Acetaminophen poisoning and liver function." N Engl J Med 331 (1994): 1311

28. Bonkovsky HL, Kane RE, Jones DP, Galinsky RE, Banner B "Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition - evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency." Hepatology 19 (1994): 1141-8

29. Seeff LB, Cuccherini BA, Zimmerman HJ, Adler E, Benjamin SB "Acetaminophen hepatotoxicity in alcoholics." Ann Intern Med 104 (1986): 399-404

30. O'Dell JR, Zetterman RK, Burnett DA "Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic." JAMA 255 (1986): 2636-7

31. Block R "Liver failure induced by paracetamol." BMJ 306 (1993): 457

32. Bray GP "Liver failure induced by paracetamol." BMJ 306 (1993): 157-8

33. Wong V, Daly M, Boon A, Heatley V "Paracetamol and acute biliary pain with cholestasis." Lancet 342 (1993): 869

34. Nelson EB, Temple AR "Acetaminophen hepatotoxicity, fasting, and ethanol." JAMA 274 (1995): 301

35. Halevi A, BenAmitai D, Garty BZ "Toxic epidermal necrolysis associated with acetaminophen ingestion." Ann Pharmacother 34 (2000): 32-4

36. Settipane RA, Stevenson DD "Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma." J Allergy Clin Immunol 84 (1989): 26-33

37. Kalyoncu AF "Acetaminophen hypersensitivity and other analgesics." Ann Allergy 72 (1994): 285

38. Doan T "Acetaminophen hypersensitivity and other analgesics - response." Ann Allergy 72 (1994): 285

39. Doan T, Greenberger PA "Nearly fatal episodes of hypotension, flushing, and dyspnea in a 47- year-old woman." Ann Allergy 70 (1993): 439-44

40. Leung R, Plomley R, Czarny D "Paracetamol anaphylaxis." Clin Exp Allergy 22 (1992): 831-3

41. Van Diem L, Grilliat JP "Anaphylactic shock induced by paracetamol." Eur J Clin Pharmacol 38 (1990): 389-90

42. Kawada A, Hiruma M, Noguchi H, Ishibashi A "Fixed drug eruption induced by acetaminophen in a 12-year-old girl." Int J Dermatol 35 (1996): 148-9

43. Bougie DW, Benito AI, Sanchez-Abarca LI, Torres R, Birenbaum J, Aster RH "Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen." Blood 109 (2007): 3608-9

44. Shoenfeld Y, Shaklai M, Livni E, Pinkhas J "Thrombocytopenia from acetaminophen." N Engl J Med 303 (1980): 47

45. Guccione JL, Zemtsov A, Cobos E, Neldner KH "Acquired purpura fulminans induced by alcohol and acetaminophen - successful treatment with heparin and vitamin-k." Arch Dermatol 129 (1993): 1267-9

46. Thomas RH, Munro DD "Fixed drug eruption due to paracetamol." Br J Dermatol 115 (1986): 357-9

47. Filipe PL, Freitas JP, Decastro JC, Silva R "Drug eruption induced by acetaminophen in infectious mononucleosis." Int J Dermatol 34 (1995): 220-1

48. Kondo K, Inoue Y, Hamada H, Yokoyama A, Kohno N, Hiwada K "Acetaminophen-induced eosinophilic pneumonia." Chest 104 (1993): 291-2

49. Brown G "Acetaminophen-induced hypotension." Heart Lung 25 (1996): 137-40

50. Koulouris Z, Tierney MG, Jones G "Metabolic acidosis and coma following a severe acetaminophen overdose." Ann Pharmacother 33 (1999): 1191-4

It is possible that some side effects of Paracetamol may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.



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Contraindications For Sterapred Oral, Sterapred

contraindications

Who should not take Sterapred?

Check with your physician if you have any of the following:

Conditions:

Muscle Problems, Increased Pressure in the Eye, Wide-Angle Glaucoma, Cataracts, Broken Bone due to Disease or Illness, Avascular Necrosis of Bone, Malaria Affecting the Brain, Muscle Wasting, Hyperammonemia associated with N-acetylglutamate synthase deficiency, Untreated Systemic Fungal Infection, High Blood Pressure, Chronic Heart Failure, Herpes Simplex Infection of the Eye, Herpes Simplex Infection, Ulcer from Stomach Acid, Burning Stomach, Diverticulitis, Surgical Joining of Two Parts of the Intestine, Hardening of the Liver, Rupture of a Tendon, Osteoporosis, Decreased Calcification or Density of Bone, Seizures, Visible Water Retention, High Blood Sugar, Intestinal Infection caused by the Roundworm Strongyloides, Active, Untreated Tuberculosis, Inactive Tuberculosis, Underactive Thyroid, Inherited Deficiency of Arginosuccinate Lyase, Inherited Deficiency of Carbamyl Phosphate Synthetase, Citrullinemia, Diabetes, Insufficiency of the Hypothalamus and Pituitary Gland, Infection caused by the Varicella Zoster Virus, Measles, Ornithine Carbamoyltransferase Deficiency, Arginase Deficiency, High Cholesterol, Low Amount of Potassium in the Blood, Reduction in the Body's Resistance to Infection, Exposure to the Measles, Exposure to the Chickenpox, Mental Disorder with Loss of Normal Personality & Reality, Muscle Pain or Tenderness with Increase Creatine Kinase

Allergies:

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Kao-Tin (Bismuth Subsalicylate) Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing,

Kao-Tin (bismuth subsalicylate)

GENERIC NAME(S): BISMUTH SUBSALICYLATE

Uses

This medication is used to treat occasional upset stomach. heartburn. and nausea. It is also used to treat diarrhea and help prevent travelers' diarrhea. It works by helping to slow the growth of bacteria that might be causing the diarrhea. This product should not be used to self-treat diarrhea if you also have a fever or blood /mucus in the stools. These could be signs of a serious health condition. Consult your doctor promptly for proper evaluation and treatment if you have these symptoms.

This medication is used under a doctor's direction with other medication to treat stomach ulcers caused by a certain bacteria (Helicobacter pylori ). Do not use this medication to self-treat ulcers. Bismuth subsalicylate is a salicylate. Salicylates can cause serious bleeding problems when used alone in patients with ulcers.

Check the ingredients on the label even if you have used the product before. The manufacturer may have changed the ingredients. Also, products with similar names may contain different ingredients meant for different purposes. Taking the wrong product could harm you.

How to use Kao-Tin (bismuth subsalicylate)

Take this medication by mouth. usually as needed, as directed by the product package or as directed by your doctor. The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take more of this medication than recommended for your age. There are many brands and forms of bismuth subsalicylate available. Read the dosing instructions carefully for each product because the dosing directions may be different between products.

If you are using the chewable tablets, chew each tablet well and swallow. If you are using the liquid form of this medication, shake the bottle well before each dose. Measure the dose carefully using a special measuring device/cup. Do not use a household spoon because you may not get the correct dose.

This medication may react with other medications (such as tetracycline antibiotics. chloroquine), preventing them from being fully absorbed by your body. Talk with your doctor or pharmacist about how to schedule your medications to prevent this problem.

If your doctor has directed you to use this medication daily, use it regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

Tell your doctor if your condition persists or worsens. If you are taking this medication for diarrhea, tell your doctor if your diarrhea lasts more than 2 days.

Side Effects

Side effects from this medication are rare. The most common side effects are darkening of the stools and/or tongue. These effects are harmless and will disappear when you stop the medication.

If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Persistent vomiting/diarrhea may result in a serious loss of body water (dehydration ). Contact your doctor promptly if you notice any symptoms of dehydration. such as unusual decreased urination, unusual dry mouth /thirst, fast heartbeat, or dizziness /lightheadedness

Tell your doctor right away if any of these unlikely but serious side effects occur: ringing ears, hearing loss .

This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. If you notice any of the following unlikely but serious side effects, stop taking this medication and consult your doctor or pharmacist right away: vomit that looks like coffee grounds, black/tarry/bloody stools, persistent stomach/abdominal pain .

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

See also Uses section.

Before taking bismuth subsalicylate, tell your doctor or pharmacist if you are allergic to it; or if you are allergic to aspirin. to salicylates (such as salsalate), or to NSAIDs (such as ibuprofen. naproxen. celecoxib ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: bleeding problems (such as hemophilia ), bloody/black/tarry stools.

If you have any of the following health problems, consult your doctor or pharmacist before using this medication gout .

This medication may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine ), consult your doctor or pharmacist about using this medication safely.

Before having surgery, tell your doctors or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This drug contains an aspirin - like product (salicylate). Children and teenagers should not take this product if they have chickenpox, flu. or any undiagnosed illness or if they have recently received a vaccine. In these cases, taking aspirin or aspirin-like products increases the risk of Reye's syndrome. a rare but serious illness.

During the first 6 months of pregnancy. this medication should be used only when clearly needed because of the salicylate. It is not recommended for use during the last 3 months of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. However, similar drugs pass into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: valproic acid. carbonic anhydrase inhibitors (such as acetazolamide ), corticosteroids (such as prednisone), methotrexate.

This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others.

Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, or naproxen) that are similar to this drug and, if taken together, may increase your risk for side effects. Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day). Consult your doctor or pharmacist for more details.

This medication may interfere with certain radiology exams (x-rays of the intestines using contrast dye), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: ringing ears, hearing loss.

Notes

If your doctor prescribes this medication for you, do not share it with others.

If you are taking this medication for diarrhea, drink plenty of water to decrease the risk of a severe loss of body water (dehydration). Consult your doctor or pharmacist for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not freeze. Do not store in the bathroom.

Different products may have different storage needs. Refer to storage information printed on the package. If you have any questions about storage, ask your pharmacist. Keep all medications and herbal products away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Cenestin (Oral) Medical Facts From, Cenestin

Cenestin

What are Cenestin (conjugated estrogens)?

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Conjugated estrogens are a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Conjugated estrogens are sometimes used as part of cancer treatment in women and men.

Conjugated estrogens may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Cenestin (conjugated estrogens)?

You should not use this medicine if you have any of the following conditions: a bleeding or blood-clotting disorder, liver disease, abnormal vaginal bleeding, history of an allergic reaction to estrogens, a hormone-related cancer such as breast or uterine cancer, or a history of heart attack, stroke, or blood clot.

Do not use if you are pregnant.

Conjugated estrogens may increase your risk of developing a condition that may lead to uterine cancer. Call your doctor at once if you have any unusual vaginal bleeding while using this medicine.

Conjugated estrogens should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions. Long-term use may also increase your risk of breast cancer or blood clot.

What should I discuss with my healthcare provider before taking Cenestin (conjugated estrogens)?

You should not use conjugated estrogens if you have:

a history of heart attack, stroke, or blood clot (especially in your lung or your lower body);

abnormal vaginal bleeding that has not been checked by a doctor;

any type of breast, uterine, or hormone-dependent cancer.

a bleeding or blood-clotting disorder;

if you are pregnant or may become pregnant; or

if you have ever had an allergic reaction to estrogens.

Conjugated estrogens will not prevent heart disease, heart attack, stroke, breast cancer, or dementia, and may actually increase your risk of developing these conditions. Long-term use may also increase your risk of breast cancer or blood clot. Talk with your doctor about your individual risks.

To make sure conjugated estrogens are safe for you, tell your doctor if you have:

unusual vaginal bleeding;

epilepsy or other seizure disorder;

liver or kidney disease;

a thyroid disorder;

high levels of calcium in your blood (hypercalcemia);

gallbladder disease; or

risk factors for coronary artery disease (such as diabetes, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40, or if you have had a hysterectomy).

Do not use conjugated estrogens if you are pregnant. Use effective birth control, and tell your doctor right away if you become pregnant while you are using this medicine.

Conjugated estrogens can pass into breast milk and may harm a nursing baby. This medicine may also slow breast milk production. Do not use if you are breast-feeding a baby.

How should I take Cenestin (conjugated estrogens)?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Conjugated estrogens may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using conjugated estrogens, to help lower this risk. Report any unusual vaginal bleeding right away.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Conjugated estrogens are sometimes taken on a daily basis. For certain conditions, the medicine is given in a cycle, such as 3 weeks on followed by 1 week off. Follow your doctor's instructions.

If you see what looks like part of a conjugated estrogen tablet in your stool, talk with your doctor.

Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms.

If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using conjugated estrogens.

Store at room temperature away from moisture and heat. Keep the medicine container tightly closed.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, or vaginal bleeding.

What should I avoid while taking Cenestin (conjugated estrogens)?

Do not smoke while using this medication. Smoking can increase your risk of blood clots, stroke, or heart attack caused by conjugated estrogens.

Cenestin (conjugated estrogens) side effects

Get emergency medical help if you have signs of an allergic reaction . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

abnormal vaginal bleeding;

a lump in your breast;

confusion, problems with memory or concentration;

heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or

signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs.

Common side effects may include:

breast pain or tenderness;

swelling in your hands or feet;

vaginal itching or discharge, changes in your menstrual periods, light vaginal bleeding or spotting;

nausea, vomiting, bloating, stomach cramps.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Cenestin (conjugated estrogens)?

Other drugs may interact with conjugated estrogens, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

More about Cenestin (conjugated estrogens)

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about conjugated estrogens.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 10.01. Revision Date: 2015-06-30, 8:10:05 AM.

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Sea-Band Anti-Nausea Ginger Gum, Travel-Gum

Sea-Band Anti-Nausea Ginger Gum 24.0ea

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What is a Flexible Spending Account (FSA)?

A Flexible Spending Account (FSA) allows consumers to deduct pre-tax dollars from their paychecks and deposit those funds in employer-sponsored accounts to pay for medical expenses. Consumers then submit expense receipts to healthcare administrators for reimbursement.

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These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Store in cool, dry place.

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Shipping Weight (in lbs): 0.1 Product in inches (LxWxH): 0.65x 2.3x 5.3 Item Code: 514281

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Warnings

Warnings Consult your physician before use if you are pregnant, nursing or before giving to children.

Warnings for self serve

Ingredients

Ingredients: Gum Base, Corn Syrup, Natural Sugar, Soya lecithin, Menthol, Color (Titanium Dioxide), Glazing Agent, Copernicia Cerifera (Carnauba) Wax, Natural Ginger Oil



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We are a free monitoring service designed for patients like you who want to be in the driver seat of your medical treatment. We have a community of more than 2.6 million members and offer the services below.

Medication Information Personalized Risk Rating Easy to understand overview Serious Side Effects Printable Medication List

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Rhinolast

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The risk of serious side effects for taking this medicine can be different if you take other medicines or if you suffer from a condition. Get your Risk Rating by creating a profile in a few steps.

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We monitor your health and alert you to any safety updates and recalls.

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Share your story! Tell us how MediGuard has helped you or someone you love. Download the MediGuard Mobile App to manage your prescription and over-the-counter medications, for free. Taking multiple medications puts you at risk for possible drug-drug interactions Monitor the medical treatment of you and your loved ones.

DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

© Quintiles 2016

Product Description Common use Astelin is an antihistamine nasal spray which is used to treat allergy symptoms such as sneezing and itchy, runny nose. This medication works by blocking the action of histamine, which reduces allergy symptoms. Also Astelin is used for treating such symptoms as runny nose or stuffy nose, and postnasal drip.

Dosage and direction

Astelin should be used for nose only, so please avoid contacting with eyes. Blow your nose before using this medication. The recommended starting dose is 4 sprays a day. After three days the recommended dose is 2 sprays a day. Note: this instruction is presented here just for a review. It's very necessary to consult your doctor before using. It will help you to get best results.

Precautions Use with cautions if your medical history include: allergies, heart disease, kidney problems, high blood pressure, liver problems. Using Astelin with alcohol or CNS depressants can increase side effects. Astelin should not be used during pregnancy, lactation or when becoming pregnant. Do not use Astelin before breast-feeding without a doctor's permission.

Astelin is not allowed to people with: allergy to any antihistamines; narrow angle glaucoma; bladder neck obstruction; symptomatic prostatic hypertrophy; asthmatic attack; stenosing peptic ulcer; pyloroduodenal obstruction. Atelin should not be used in neonates (possible association with SIDS)

Possible side effect

They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: bronchospasm (shortness of breath, tightness in chest, wheezing); fast or uneven heartbeats. Less serious include: a bitter taste in your mouth; headache; drowsiness or dizziness; dry mouth, sore throat; burning in your nose; weight gain; nausea; nosebleed; cough, sneezing, runny nose, cold symptoms; or eye redness. If you experience one of them stop using Astelin and tell your doctor as soon as possible. Also consult your doctor about any side effect that seems unusual.

Astelin interact with such medication as: cimetidine, sleep medicines, sedatives, tranquilizers, drugs for anxiety, narcotic pain relievers, antidepressants or other psychiatric drugs, other antihistamines. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the effect of drugs, so consult your doctor about how these interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usual dose next day at the same regularly time.

Overdose Symptoms of an Astelin overdose are unknown, but possibly may include extreme sleepiness. If you experience one of them or if you experience any unusual symptom call your doctor immediately.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Store away from heat, moisture, and light. Do not store in the bathroom. Keep the bottle upright with the pump tightly closed. Protect from freezing. Keep out of the reach of children.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Product Description Common use Astelin is an antihistamine nasal spray which is used to treat allergy symptoms such as sneezing and itchy, runny nose. This medication works by blocking the action of histamine, which reduces allergy symptoms. Also Astelin is used for treating such symptoms as runny nose or stuffy nose, and postnasal drip.

Dosage and direction

Astelin should be used for nose only, so please avoid contacting with eyes. Blow your nose before using this medication. The recommended starting dose is 4 sprays a day. After three days the recommended dose is 2 sprays a day. Note: this instruction is presented here just for a review. It's very necessary to consult your doctor before using. It will help you to get best results.

Precautions Use with cautions if your medical history include: allergies, heart disease, kidney problems, high blood pressure, liver problems. Using Astelin with alcohol or CNS depressants can increase side effects. Astelin should not be used during pregnancy, lactation or when becoming pregnant. Do not use Astelin before breast-feeding without a doctor's permission.

Astelin is not allowed to people with: allergy to any antihistamines; narrow angle glaucoma; bladder neck obstruction; symptomatic prostatic hypertrophy; asthmatic attack; stenosing peptic ulcer; pyloroduodenal obstruction. Atelin should not be used in neonates (possible association with SIDS)

Possible side effect

They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: bronchospasm (shortness of breath, tightness in chest, wheezing); fast or uneven heartbeats. Less serious include: a bitter taste in your mouth; headache; drowsiness or dizziness; dry mouth, sore throat; burning in your nose; weight gain; nausea; nosebleed; cough, sneezing, runny nose, cold symptoms; or eye redness. If you experience one of them stop using Astelin and tell your doctor as soon as possible. Also consult your doctor about any side effect that seems unusual.

Astelin interact with such medication as: cimetidine, sleep medicines, sedatives, tranquilizers, drugs for anxiety, narcotic pain relievers, antidepressants or other psychiatric drugs, other antihistamines. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the effect of drugs, so consult your doctor about how these interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usual dose next day at the same regularly time.

Overdose Symptoms of an Astelin overdose are unknown, but possibly may include extreme sleepiness. If you experience one of them or if you experience any unusual symptom call your doctor immediately.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Store away from heat, moisture, and light. Do not store in the bathroom. Keep the bottle upright with the pump tightly closed. Protect from freezing. Keep out of the reach of children.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Product Description Common use Astelin is an antihistamine nasal spray which is used to treat allergy symptoms such as sneezing and itchy, runny nose. This medication works by blocking the action of histamine, which reduces allergy symptoms. Also Astelin is used for treating such symptoms as runny nose or stuffy nose, and postnasal drip.

Dosage and direction

Astelin should be used for nose only, so please avoid contacting with eyes. Blow your nose before using this medication. The recommended starting dose is 4 sprays a day. After three days the recommended dose is 2 sprays a day. Note: this instruction is presented here just for a review. It's very necessary to consult your doctor before using. It will help you to get best results.

Precautions Use with cautions if your medical history include: allergies, heart disease, kidney problems, high blood pressure, liver problems. Using Astelin with alcohol or CNS depressants can increase side effects. Astelin should not be used during pregnancy, lactation or when becoming pregnant. Do not use Astelin before breast-feeding without a doctor's permission.

Astelin is not allowed to people with: allergy to any antihistamines; narrow angle glaucoma; bladder neck obstruction; symptomatic prostatic hypertrophy; asthmatic attack; stenosing peptic ulcer; pyloroduodenal obstruction. Atelin should not be used in neonates (possible association with SIDS)

Possible side effect

They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: bronchospasm (shortness of breath, tightness in chest, wheezing); fast or uneven heartbeats. Less serious include: a bitter taste in your mouth; headache; drowsiness or dizziness; dry mouth, sore throat; burning in your nose; weight gain; nausea; nosebleed; cough, sneezing, runny nose, cold symptoms; or eye redness. If you experience one of them stop using Astelin and tell your doctor as soon as possible. Also consult your doctor about any side effect that seems unusual.

Astelin interact with such medication as: cimetidine, sleep medicines, sedatives, tranquilizers, drugs for anxiety, narcotic pain relievers, antidepressants or other psychiatric drugs, other antihistamines. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the effect of drugs, so consult your doctor about how these interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usual dose next day at the same regularly time.

Overdose Symptoms of an Astelin overdose are unknown, but possibly may include extreme sleepiness. If you experience one of them or if you experience any unusual symptom call your doctor immediately.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Store away from heat, moisture, and light. Do not store in the bathroom. Keep the bottle upright with the pump tightly closed. Protect from freezing. Keep out of the reach of children.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.



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Malarone Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Malafene

Malarone

Uses

This medication contains 2 medicines: atovaquone and proguanil. It is used to prevent and treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites. and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells and other tissues. In some cases, you may need to take a different medication (such as primaquine ) to complete your treatment. Both medications may be needed for a complete cure and to prevent the return of infection (relapse). Atovaquone/proguanil belongs to a class of drugs known as antimalarials.

The United States Centers for Disease Control provide updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Discuss the most recent information with your doctor before traveling to areas where malaria occurs.

How to use Malarone

Read the Patient Information Leaflet if available from your pharmacist before you start taking this medication, and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist.

Take this medication by mouth with food or a milky drink (such as whole milk, milkshake) that contains fat. If you vomit within 1 hour of taking a dose, repeat the dose. If you have persistent vomiting after taking atovaquone/proguanil, contact a doctor right away. You may need another medication to prevent vomiting or a different malaria medication.

Swallow the tablet whole because of its bitter taste. Do not chew. If you have trouble swallowing tablets, this medication may be crushed and mixed with condensed milk. Take the entire mixture right away. Do not save for future use.

Dosage is based on your medical condition, on whether you are preventing or treating the illness, and your response to treatment. Dosage in children is also based on weight .

To prevent illness, take atovaquone/proguanil usually once daily at the same time each day, or as directed by your doctor. Start this medication 1-2 days before you enter the malarious area; continue while in the area and for 7 days after leaving.

If needed, primaquine can be taken for 14 days starting during the last week of treatment with atovaquone/proguanil or starting immediately after you have finished treatment.

To treat malaria, take this medication usually once daily for 3 days. Follow your doctor's instructions.

It is very important to continue taking this medication exactly as prescribed by your doctor. To help you remember, take it at the same time each day for the entire prescribed time.

Do not take more or less of this drug than prescribed. Do not stop taking this drug before completing the full treatment unless directed to do so by your doctor, even if you feel better or do not feel sick. Skipping or changing your dose without approval from your doctor may cause prevention/treatment to be ineffective, cause the amount of parasite to increase, make the infection more difficult to treat (resistant), or worsen side effects.

It is important to prevent mosquito bites (such as by using appropriate insect repellents, wearing clothes that cover most of the body, remaining in air-conditioned or well-screened areas, using mosquito nets and insect-killing sprays). Buy insect repellent before traveling. The most effective insect repellents contain diethyltoluamide (DEET). Ask your doctor or pharmacist to recommend the appropriate strengths of mosquito repellent for you/your children.

No drug treatment is completely effective in preventing malaria. Seek immediate medical attention if you develop symptoms of malaria (such as fever, chills, headache. other flu - like symptoms). Malaria can return, even months after completing this prescription. Quick treatment of malaria infection is needed to prevent serious, possibly fatal, outcomes.

When using atovaquone/proguanil for treatment, tell your doctor if your condition persists or worsens.

Side Effects

See also How to Use section.

Side effects may include nausea, vomiting, abdominal pain. headache. diarrhea. weakness. loss of appetite, and dizziness. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these rare but very serious side effects occur: signs of serious liver problems (such as persistent/severe nausea and vomiting, abdominal pain, unexplained tiredness, dark urine, yellowing eyes /skin ), signs of anemia (such as worsening tiredness, rapid breathing, pale skin/lips/nails, fast heartbeat while resting), signs of severe infection (such as high fever. severe chills, body aches, sore throat ).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking atovaquone/proguanil, tell your doctor or pharmacist if you are allergic to either atovaquone or proguanil; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: current diarrhea, current vomiting, kidney problems, liver problems, mental/mood problems, seizures .

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy. this medication should be used only when clearly needed. While you are pregnant, traveling to an area with malaria places you and your infant at a much higher risk for death and other problems. Discuss the risks and benefits of malaria prevention with your doctor.

It is not known if atovaquone passes into breast milk and may have undesirable effects on a nursing infant. The proguanil in this medication passes into breast milk and the effects of this medication on a nursing infant are not known. The CDC recommends against using this product for malaria prevention if you are breastfeeding an infant weighing less than 11 pounds (5 kilograms). Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: penicillamine, "blood thinners" (such as warfarin), metoclopramide .

Other medications can affect the removal of atovaquone/proguanil from your body, which may affect how atovaquone/proguanil works. Examples include efavirenz, rifampin, rifabutin, tetracycline, among others.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as blood cell counts, liver tests) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised February 2016. Copyright(c) 2016 First Databank, Inc.

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Bactelan - ?Tu Colega Siempre En Linea, Bactelan

BACTELAN

BACTELAN TABLETAS Antibiotico de amplio espectro QUIMICA Y FARMACIA, S. A. de C. V.

- DENOMINACION GENERICA - FORMA FARMACEUTICA Y FORMULACION - INDICACIONES TERAPEUTICAS - FARMACOCINETICA Y FARMACODINAMIA EN HUMANOS - CONTRAINDICACIONES - PRECAUCIONES GENERALES - RESTRICCIONES DE USO DURANTE EL EMBARAZO Y LA LACTANCIA - REACCIONES SECUNDARIAS Y ADVERSAS - INTERACCIONES MEDICAMENTOSAS Y DE OTRO GENERO - ALTERACIONES EN LOS RESULTADOS DE PRUEBAS DE LABORATORIO - PRECAUCIONES EN RELACION CON EFECTOS DE CARCINOGENESIS, MUTAGENESIS, TERATOGENESIS Y SOBRE LA FERTILIDAD - DOSIS Y VIA DE ADMINISTRACION - MANIFESTACIONES Y MANEJO DE LA SOBREDOSIFICACION O INGESTA ACCIDENTAL - PRESENTACIONES - RECOMENDACIONES SOBRE ALMACENAMIENTO - LEYENDAS DE PROTECCION - LABORATORIO Y DIRECCION - NUMERO DE REGISTRO Y CLAVE IPPA

Trimetoprim y sulfametoxazol.

FORMA FARMACEUTICA Y FORMULACION:

Cada tableta contiene:

Trimetoprim. 80 y 160 mg

Sulfametoxazol. 400 y 800 mg

Excipiente, cbp. 1 tableta

· Antimicrobiano (sulfamidoterapia) para infecciones ocasionadas por germenes sensibles.

· Infecciones de vias respiratorias superiores o inferiores: Rinitis, sinusitis, faringitis, amigdalitis, traqueitis, bronquitis aguda o cronica, neumonia y bronconeumonia.

· Infecciones genitourinarias: Cistitis aguda o cronica, pielocistitis, pielonefritis, uretritis gonococicas.

· Infecciones del aparato digestivo: Paratifoidea, tifoidea, gastroenteritis y disenteria bacilar.

· Infecciones de la piel: Piodermias, furunculos, abscesos y heridas infectadas.

· Oculares: Conjuntivitis, blefaritis y sepsis neonatal, septicemias y peritonitis.

FARMACOCINETICA Y FARMACODINAMIA EN HUMANOS:

BACTELAN es un medicamento a base de una asociacion sinergica de trimetoprim y sulfametoxazol. Cuando el medicamento se administra por via oral, las concentraciones plasmaticas de trimetoprim y sufametoxazol estan generalmente en una proporcion 1:20. En la orina, esta relacion puede variar de 1:1 a 1:15 dependiendo del pH. Cerca de 50% de trimetoprim y de 50% de sulfametoxazol administrados se excretan en la orina en 24 horas.

El trimetoprim y el sulfametoxazol se absorben en forma rapida y casi completa de la porcion superior del tracto gastrointestinal tras la administracion oral.

El sulfametoxazol se absorbe mas lentamente que el trimetoprim y se distribuye ampliamente en tejidos y liquidos, incluyendo el pleural, peritoneal, sinovial y ocular. Atraviesa facilmente la barrera placentaria.

La union a proteinas es variable, menor en pacientes con disfuncion renal severa.

Los principales metabolitos de trimetoprim son 1- y 3-oxidos y los derivados 3- y 4-hidroxi; algunos metabolitos son microbiologicamente activos. El sulfametoxazol se metaboliza en el higado, predominantemente por acetilacion N4 y en menor grado por conjucion de glucuronidos.

En humanos se ha detectado trimetoprim y sulfametoxazol en tejidos fetales (placenta, higado, pulmon), en la sangre del cordon umbilical y en el fluido amniotico, indicando la transferencia placentaria de ambos farmacos. En general, las concentraciones fetales de trimetoprim son similares a las maternas y las de sulfametoxazol son menores.

La vida media es de 6 a 12 horas, de 20 a 50 horas en el estadio final de la insuficiencia renal.

La concentracion plasmatica maxima se alcanza en 2 a 4 horas. Ambas sustancias, asi como sus metabolitos, se eliminan por filtracion glomerular y secrecion tubular, dando concentraciones en la orina de ambas sustancias activas considerablemente mayores que las concentraciones en la sangre. La excrecion aumenta en la orina alcalina.

Se excretan pequenas cantidades en las heces, leche materna, bilis y otras secreciones corporales.

Mecanismo de accion: Los 2 componentes interfieren con la sintesis bacteriana de acido tetrahidrofolico. Intermediario esencial para la produccion de acidos nucleicos.

Las bacterias sensibles son las que requieren sintetizar el acido p-aminobenzoico (PABA). La accion de las sulfas es antagonizada por el PABA y las sustancias similares, procaina y tetraciclina.

En las afecciones graves del parenquima hepatico, discrasias sanguineas, y en la insuficiencia renal grave, cuando se pueden determinar regularmente las concentraciones plasmaticas.

No debera administrarse a pacientes con antecedentes de hipersensibilidad a las sulfamidas o a trimetoprim, pacientes con anemia megaloblastica.

Ya que trimetoprim y sulfametoxazol pueden encontrarse en la leche materna y representaria un riesgo insignificante para el lactante, no se administre durante el embarazo, la lactancia ni en ninos menores de tres meses.

· Visitar regularmente al medico para comprobar el progreso experimentado con el tratamiento a largo plazo o con el tratamiento a dosis elevadas.

· Consultar con el medico si no se notara mejoria en unos dias.

· Precaucion si se precisa cirugia con anestesia general.

· Usar los cepillos, seda y palillos dentales con precaucion; retrasar el trabajo odontologico hasta que los recuentos sanguineos vuelvan a los valores normales; consultar con el medico o dentista en relacion con la higiene oral adecuada.

· Es posible que se produzcan reacciones de fotosensibilidad.

· No se administre en ninos menores de 3 meses de edad.

· Debera suspenderse inmediatamente el tratamiento a la primera aparicion de erupcion cutanea o cualquier otra reaccion adversa grave.

· En caso de insuficiencia renal debera ajustarse la dosis de acuerdo con las instrucciones especiales de administracion.

· BACTELAN debera administrarse con cuidado en pacientes con historia de alergias graves y asma bronquial.

· Existe un riesgo aumentado de efectos adversos en pacientes ancianos o cuando existen otras complicaciones, como funcion hepatica y/o renal disminuida o el uso concomitante de otros farmacos (en cuyo caso el riesgo podra estar relacionado a la dosis y duracion del tratamiento).

· Para minimizar el riesgo de reacciones adversas, la duracion del tratamiento con BACTELAN debera ser tan corta como sea posible, especialmente en pacientes ancianos.

· Si se administra BACTELAN durante periodos prolongados, se requiere de conteos sanguineos prolongados. Si se detecta una reduccion significativa en la cuenta de cualquier elemento sanguineo formado, debera suspenderse el tratamiento. A menos que se trate de un caso excepcional, no se debera administrar este farmaco en pacientes con desordenes hematologicos serios.

RESTRICCIONES DE USO DURANTE EL EMBARAZO Y LA LACTANCIA:

Embarazo: No se administre durante el embarazo ni la lactancia. Las sulfamidas y trimetoprim atraviesan la barrera placentaria. Normalmente no se produce kernicterus o hiperbilirrubinemia significativa en el recien nacido, debido a que la bilirrubina se conjuga en el higado de la madre.

Durante la ultima fase del embarazo, debera evitarse este farmaco tanto como sea posible, debido al riesgo de kernicterus en el neonato.

Lactancia: El sulfametoxazol y trimetoprim se excretan en la leche materna, solo aparece en la leche 1% de la dosis materna de sulfametoxazol y 0.2% de trimetoprim.

Las sulfamidas pueden producir anemia hemolitica en neonatos con deficiencia de glucosa-6-fosfato deshidrogenasa (G6PD), por lo tanto, no se debe administrar en el periodo de lactancia.

La asociacion de sulfametoxazol y trimetoprim en proporcion (1:5) es inadecuada en neonatos y lactantes mayores, debido a la disposicion alterada del sulfametoxazol y de trimetoprim en estos pacientes.

REACCIONES SECUNDARIAS Y ADVERSAS:

Siguiendo la posologia recomendada, BACTELAN es bien tolerado; sin embargo, como todas las sulfamidas, pueden presentarse nauseas, vomitos, exantemas, sindrome de Stevens-Johnson (eritema multiforme buloso), granulocitopenia, trombocitopenia, leucopenia y sindrome de Lyell (necrolisis epidermica toxica). Purpura, neutropenia, raramente agranulocitosis.

Estas reacciones son mas frecuentes en ancianos, en insuficiencia renal y en el empleo concomitante de otros farmacos (tiazidas, pirimetamina, etc.).

Se puede requerir ajuste de la dosis de anticoagulantes warfarinicos, fenitoina, metotrexato, hipoglucemiantes orales, etc. administrados concomitantemente.

INTERACCIONES MEDICAMENTOSAS Y DE OTRO GENERO:

En pacientes ancianos puede ocurrir una elevacion en los niveles en sangre de la digoxina.

Puede aumentar el efecto hipotrombotico de los anticoagulantes warfarinicos. Potencia el efecto de los hipoglucemiantes orales.

BACTELAN puede disminuir la eficacia de los antidepresivos triciclicos. El sulfametoxazol compite con la union a proteinas del metotrexato. La eficacia de los antidepresivos triciclicos puede disminuir cuando se administran conjuntamente con BACTELAN.

ALTERACIONES EN LOS RESULTADOS DE PRUEBAS DE LABORATORIO:

Se pueden producir falsas-positivas en la deteccion de glucosa en orina con el reactivo de Benedic, determinacion de proteinas en orina con la prueba del acido sulfosalicilico.

BACTELAN interfiere con la medicion de las concentraciones plasmaticas de la urea.

El trimetoprim puede interferir con un ensayo de metotrexato sodico que utiliza la tecnica de union competitiva a las proteinas cuando se utiliza dihidrofolato reductasa bacteriana, como la proteina de union. La presencia de trimetoprim y sulfametoxazol puede tambien interferir con la reaccion de picrato alcalino de Jaffe para la creatinina, provocando que los valores normales aumenten aproximadamente en 10%.

PRECAUCIONES EN RELACION CON EFECTOS DE CARCINOGENESIS, MUTAGENESIS, TERATOGENESIS Y SOBRE LA FERTILIDAD:

Carcinogenesis: Estudios a largo plazo para evaluar el potencial carcinogenico en animales no han sido llevados a cabo.

Mutagenesis: Estudios para evaluar la mutagenicidad bacteriana no han sido llevados a cabo con sulfametoxazol y trimetoprim en combinacion. El trimetoprim ha demostrado ser no mutagenico en los estudios realizados.

Las observaciones realizadas en leucocitos de pacientes tratados con BACTELAN no han revelado ninguna anormalidad cromosomica.

Fertilidad: No se han observado efectos sobre la fertilidad o capacidad reproductiva en ratas a dosis tan altas como 70 mg/kg/dia de trimetoprim mas 300 mg/kg/dia de sulfametoxazol.

Estudios realizados en mujeres embarazadas han revelado anormalidades congenitas en un porcentaje de 4.5% cuando la paciente recibio trimetoprim-sulfametoxazol durante el primer trimestre del embarazo.

DOSIS Y VIA DE ADMINISTRACION:

La dosificacion es cada 12 horas.

Tabletas 80 mg/400 g

Tabletas 160 mg/800 mg



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Your tax-deductible gift will fund critical diabetes research, education and awareness programs that will improve the lives of those with diabetes. Your gift includes the choice of an email or print announcement card for your gift recipient.

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This special matching gift offer is brought to you by our campaign sponsor, Amaranth Diabetes Foundation. We are grateful for their support of the American Diabetes Association and people with diabetes. Donations to this matching gift campaign will be directed 100% to Association-funded diabetes research. Donations or contributions to Step Out: Walk to Stop Diabetes®, Tour de Cure®, or other special event fundraising campaigns do not qualify for this matching gift offer.

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Help give the gift of diabetes summer camp to a child like yours.

Give a child living with diabetes the life-changing experience of spending a whole week having fun and learning how to better manage this tough disease with other kids who all have diabetes, too.

It's tough to feel like you're the only person in the world who has to deal with diabetes, but then you go to camp. Camp is a place where I feel safe and people understand what I'm going through. When I'm there, everyone gets it, no one stares and there's no explanation necessary.

Nearly 30 million battle diabetes.

Today, 1 in 11 Americans is living with diabetes. Millions more are at high risk of developing diabetes. We must take bold action and increase our investment in diabetes research now to turn this tide. But with your support today, we can continue to fight back.

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Please use our Memorial Donation Form or Honor Donation Form to make a donation to honor someone you love or remember someone you've lost. You can also make your donation by phone at 1-800-DIABETES (1-800-342-2383) or by mail .

Nearly 30 million battle diabetes.

Today, 1 in 11 Americans is living with diabetes. Millions more are at high risk of developing diabetes. We must take bold action and increase our investment in diabetes research now to turn this tide. But with your support today, we can continue to fight back.

Today, 1 in 11 Americans is living with diabetes. Millions more are at high risk of developing diabetes. We must take bold action and increase our investment in diabetes research now to turn this tide.

Please use our Memorial Donation Form or Honor Donation Form to make a donation to honor someone you love or remember someone you've lost. You can also make your donation by phone at 1-800-DIABETES (1-800-342-2383) or by mail .

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Please use our Memorial Donation Form or Honor Donation Form to make a donation to honor someone you love or remember someone you've lost. You can also make your donation by phone at 1-800-DIABETES (1-800-342-2383) or by mail .

Why Camp Matters

A Chance to be a Kid

At camp, kids get to be kids. For many kids it’s the first time they aren’t the kid with diabetes. They can talk openly and freely about their struggles and everyone understands. They build friendships that last a lifetime.

Empowerment to Manage Diabetes

Camp teaches kids valuable lessons on how to manage diabetes. They check their sugar levels before and after activities, count carbohydrates at each meal and snack, and many are learn how to figure out the correct insulin dose and give themselves their first insulin injection or move their insulin pump site for the first time.

Build Confidence & Independence

For many kids, camp is the first time they have been away from their parents who help them manage their diabetes. Being away from home and tackling intimidating diabetes management challenges, campers gain self-confidence. They make new friends and try new sports and activities - all help build campers’ confidence and become more independent.

Please take a few moments to watch a short video about our camp program that serves 6,000 children every summer. Our campers have FUN while connecting with other kids like them, sharing their highs and lows and learning how to better manage their diabetes all in a safe environment surrounded by trained staff and medical professionals.

Providing a wonderful summer camp experience for children with diabetes is just one of the ways we serve the diabetes community. By donating today, you will also help us advance diabetes research to find new treatments and ultimately cure and improve the lives of everyone affected by diabetes.

Providing a wonderful summer camp experience for children with diabetes is just one of the ways we serve the diabetes community. By donating today, you will also help us advance diabetes research to find new treatments and ultimately cure and improve the lives of everyone affected by diabetes.

Please use our Memorial Donation Form or Honor Donation Form to make a donation to honor someone you love or remember someone you've lost. You can also make your donation by phone at 1-800-DIABETES (1-800-342-2383) or by mail .

In the next 48 hours, 7,670 Americans will be diagnosed with diabetes, changing their lives forever. There's no sugarcoating it– diabetes is bad news . It makes everything harder—from eating a meal to staying healthy to being treated fairly at work and school and so much more.

That's why we want to show these people that they're not alone during what is probably a very tough time in their lives. Show them that you stand with them by making a gift to help fight this devastating disease. No matter how much you’re able to give, your tax-deductible gift will help speed the search for a cure and improve care for people living with diabetes, as well as prevent more Americans from developing this deadly disease. #GiveForDiabetes

In the next 48 hours, 7,670 Americans will be diagnosed with diabetes, changing their lives forever. There's no sugarcoating it– diabetes is bad news . It makes everything harder—from eating a meal to staying healthy to being treated fairly at work and school and so much more.

Please use our Memorial Donation Form or Honor Donation Form to make a donation to honor someone you love or remember someone you've lost. You can also make your donation by phone at 1-800-DIABETES (1-800-342-2383) or by mail .

STANDING TOGETHER – OUR WONDERFUL SUPPORTERS

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American Diabetes Association 1701 North Beauregard Street Alexandria, VA 22311 1-800-DIABETES(800-342-2383)

Copyright 1995-. American Diabetes Association. All rights reserved. Use of this website constitutes acceptance of our Terms of Use and Privacy Policy .

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Akbeta Ophthalmic Drug Information On Uses, Side Effects, Interactions, And User Reviews On Rxlist,

AKBeta ophthalmic

AKBeta ophthalmic Uses

This medication is used alone or with other medications to treat high pressure inside the eye due to glaucoma (open-angle type) or other eye diseases (e. g. ocular hypertension). Lowering high pressure inside the eye helps to prevent blindness. Levobunolol belongs to a class of drugs known as beta blockers and works by decreasing the amount of fluid production within the eye.

How to use AKBeta ophthalmic

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

If you are wearing contact lenses, remove them before using eye drops. Wait at least 15 minutes before replacing your contact lenses.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch, usually once or twice daily or as directed by your doctor. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed or if your dose is for more than 1 drop.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e. g. drops or ointments), wait at least 5 to 10 minutes before using the other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day. It is important to continue using this medication even if you feel well. Most people with glaucoma or high pressure in the eyes do not feel sick.

AKBeta ophthalmic Side Effects

Temporary burning/stinging of the eye, itchy/red eyes, headache, or dizziness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: eye pain/swelling/discharge, reduced feeling in eye, slow/irregular heartbeat, muscle weakness, hair loss, mental/mood changes, vision changes, tiredness, swelling of the ankles/feet, sudden/unexplained weight gain.

Seek immediate medical attention if any of these rare but very serious side effects occur: trouble breathing, chest pain, weakness on one side of the body, slurred speech, confusion.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

AKBeta ophthalmic Precautions

Before using levobunolol, tell your doctor or pharmacist if you are allergic to it; or to other beta-blockers (e. g. timolol, metipranolol); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride, sulfites), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problems (e. g. asthma or a history of asthma, chronic obstructive pulmonary disease-COPD), certain types of heart rhythm problems (e. g. sinus bradycardia, second - or third-degree atrioventricular block), certain serious heart conditions (e. g. cardiogenic shock, severe heart failure).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease (e. g. bronchitis, emphysema), diabetes, heart failure (treated, stable type), blood circulation problems (e. g. cerebrovascular insufficiency), overactive thyroid (hyperthyroidism), muscle weakness disorders (e. g. myasthenia gravis).

Before having surgery, tell your doctor or dentist that you are using this medication.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

If you have diabetes, this product may mask the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of a low blood sugar level, such as dizziness/sweating, are unaffected by this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

AKBeta ophthalmic Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: digoxin, drugs for high blood pressure (e. g. clonidine, reserpine, oral beta blockers such as propranolol, calcium channel blockers such as diltiazem), epinephrine, fingolimod, phenothiazines (e. g. prochlorperazine).

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

AKBeta ophthalmic Overdose

This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. If this product is accidentally swallowed, you may experience symptoms such as trouble breathing, slow/irregular heartbeat.

Do not share this medication with others.

Laboratory and/or medical tests (e. g. eye exams) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.



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Lakemedel Normorix Mite Tablett 2, 5 Mg, Normorix

Las noga igenom denna bipacksedel innan du borjar anvanda detta lakemedel. - Spara denna bipacksedel, du kan behova lasa om den.

- Om du har ytterligare fragor vand dig till din lakare eller farmaceut.

- Detta lakemedel har ordinerats at dig personligen. Du bor inte ge det vidare till andra. Det kan skada dem, aven om de uppvisar symptom som liknar dina.

I denna bipacksedel finner du information om: 1. Vad Normorix och Normorix mite ar och vad det anvands for 2. Innan du anvander Normorix och Normorix mite 3. Hur du anvander Normorix och Normorix mite 4. Eventuella biverkningar 5. Hur Normorix och Normorix mite ska forvaras 6. Ovriga upplysningar

1. VAD NORMORIX OCH NORMORIX MITE AR OCH VAD DET ANVANDS FOR

Normorix och Normorix mite ar urindrivande och blodtryckssankande medel. De bada verksamma amnena kompletterar varandra pa sa satt att hydroklortiazid ar urindrivande och blodtryckssankande medan amiloridhydroklorid ar kaliumsparande och motverkar de kaliumforluster som kan orsakas av urindrivande medel. Amiloridhydroklorid har dessutom en mild urindrivande och blodtryckssankande effekt och forstarker darmed effekten av hydroklortiazid.

Den okade urinutsondringen borjar inom 1-2 timmar efter intag, ar som storst efter ungefar

4 timmar och varar ca 12 timmar.

Normorix och Normorix mite anvands for behandling av hogt blodtryck eller vatskeansamling i vavnaderna (odem) beroende pa hjartsvikt, skrumplever med vatskeansamling i bukhalan.

Amiloridhydroklorid och hydroklortiazid som finns i Normorix och Normorix mite kan ocksa vara godkanda for att behandla andra sjukdomar som inte namns i denna bipacksedel. Fraga lakare, apotekspersonal eller annan halso - och sjukvardspersonal om du har ytterligare fragor och folj alltid deras instruktion.

2. INNAN DU ANVANDER NORMORIX OCH NORMORIX MITE Anvand inte Normorix och Normorix mite •om du ar allergisk (overkanslig) mot hydroklortiazid eller amiloridhydroklorid eller mot nagot av ovriga innehallsamnen i Normorix eller Normorix mite. Detta galler aven om du ar allergisk mot amnen som ar narbeslaktade till de aktiva substanserna, t ex sa kallade tiazider (urindrivande medel) eller sulfonamider (t ex vissa diabetesmedel som tas via munnen).

•om du har kraftigt forsamrad njurfunktion, har forhojd halt kalium i blodet eller om du anvander andra kaliumsparande medel (t ex spironolakton) eller kaliumtillagg.

•om du inte har nagon urinutsondring

•om du har paverkat medvetande som en foljd av skrumplever.

•om du har gikt.

Var sarskilt forsiktig med Normorix och Normorix mite •vid foljande tillstand bor du radgora med lakaren innan behandling med Normorix eller Normorix mite paborjas: hog alder, nedsatt njurfunktion, diabetes, forhojd kaliumhalt i blodet, lupus erytematosus (SLE), hjart-lungsjukdomar, leverproblem samt om du skall gora ett glukostoleranstest.

•infor kirurgiska ingrepp med narkos (galler aven hos tandlakaren) bor lakaren/tandlakaren kanna till att du behandlas med Normorix eller Normorix mite, eftersom risk finns att blodtrycket kan sjunka plotsligt.

•Normorix/Normorix mite kan i sallsynta fall paverka de vita blodkropparna sa att infektionsforsvaret forsamras. Om du far en infektion med symtom sasom feber med kraftigt forsamrat allmantillstand eller feber med lokala infektionssymtom sasom exempelvis ont i halsen/svalget/munnen eller vattenkastningsbesvar, ska du snarast uppsoka lakare sa att man via blodprov kan utesluta en brist pa vita blodkroppar (agranulocytos). Det ar viktigt att du da informerar om din medicinering.

•om du har avflodeshinder i urinvagarna.

Anvandning av andra lakemedel Effekten av behandlingen kan paverkas om Normorix eller Normorix mite tas samtidigt med vissa andra lakemedel. Tala om for lakare eller apotekspersonal om du tar eller nyligen har tagit andra lakemedel, aven receptfria sadana. Detta galler framforallt:

•andra kaliumsparande medel eller kaliumtillagg

•andra blodtryckssankande medel (ACE-hammare)

•insulin och diabetesmedel

•vissa blodfettsankande medel (kolestyramin, kolestipol)

•hjartmedicin (digitalis, sotalol, epinefrin)

•vissa medel mot smarta/inflammation (t ex acetylsalicylsyra och ibuprofen)

•vissa medel mot depression (litium)

•vissa lakemedel som sanker immunforsvaret (ciklosporin och takrolimus)

•vissa medel mot stord kalciumomsattning (kalcitriol)

•vissa medel mot epilepsi (karbamazepin, topiramat)

•vissa medel mot cancer (cyklofosfamid)

•kalciuminnehallande medel, t ex kalciumtillagg och vissa medel mot sur mage (sa kallade antacida)

Alkohol och vissa lugnande mediciner kan oka den blodtryckssankande effekten hos Normorix och Normorix mite.

Intag av Normorix och Normorix mite med mat och dryck Du bor undvika intag av stora mangder mejeriprodukter eller andra kalciuminnehallande livsmedel.

Graviditet och amning Radfraga lakare eller apotekspersonal innan du tar nagot lakemedel.

Graviditet: Risk finns att fostret paverkas. Radgor darfor alltid med lakare fore anvandning av Normorix eller Normorix mite under graviditet.

Amning: Barn som ammas paverkas formodligen inte. Normorix och Normorix mite rekommenderas ej under den forsta manadens amning, eftersom mjolkavsondringen kan hammas.

Korformaga och anvandning av maskiner Biverkningar sasom yrsel och trotthet kan forekomma. Under dessa forhallanden kan reaktionsformagan och omdomesformagan minska och detta bor observeras t ex vid bilkorning och precisionsbetonat arbete. Du ar sjalv ansvarig for att bedoma om du ar i kondition att framfora motorfordon eller utfora arbete som kraver skarpt uppmarksamhet. En av faktorerna som kan paverka din formaga i dessa avseenden ar anvandning av lakemedel pa grund av deras effekter och/eller biverkningar. Beskrivning av dessa effekter och biverkningar finns i andra avsnitt. Las darfor all information i denna bipacksedel for vagledning. Diskutera med din lakare eller apotekspersonal om du ar osaker.

Viktig information om nagot(ra) innehallsamne(n) i Normorix och Normorix mite Normorix och Normorix mite innehaller laktos. Om du inte tal vissa sockerarter, bor du kontakta din lakare innan du tar denna medicin.

3. HUR DU ANVANDER NORMORIX OCH NORMORIX MITE

Anvand alltid Normorix och Normorix mite enligt lakarens anvisningar. Radfraga lakare eller apotekspersonal om du ar osaker. Dosen bestams av lakaren, som avpassar den individuellt for dig. Vanlig dos ar 1 tablett dagligen. Andra inte doseringen utan att radgora med din lakare.

Om du anvant for stor mangd av Normorix och Normorix mite Om du fatt i dig for stor mangd lakemedel eller om t ex ett barn fatt i sig lakemedlet av misstag kontakta lakare, sjukhus eller Giftinformationscentralen (tel. 112) for bedomning av risken samt radgivning.

Om du har glomt att ta Normorix och Normorix mite Ta inte dubbel dos for att kompensera for glomd tablett Aterga till det vanliga schemat nastfoljande dag.

Om du har ytterligare fragor om detta lakemedel kontakta lakare eller apotekspersonal.

4. EVENTUELLA BIVERKNINGAR Liksom alla lakemedel kan Normorix och Normorix mite orsaka biverkningar men alla anvandare behover inte fa dem.

Vanliga (forekommer hos fler an 1 patient av 100):

Trotthet, svaghet, aptitloshet, huvudvark och yrsel.

Illamaende, diarre och matsmaltningsbesvar.

Hudutslag, klada, vark i ben och armar, andnod, hosta och oregelbunden hjartrytm.

Forhojda blodsockervarden, forhojda eller sankta (vid langtidsanvandning) kaliumnivaer i blodet. Sankta magnesiumnivaer i blodet. Okad mangd urinsyra i blodet.

Mindre vanliga (forekommer hos fler an 1 patient av 1 000, men farre an 1 av 100):

Krakningar, forstoppning, gasbildning, hicka, muntorrhet och torst.

Somnloshet, nervositet, depression, sankt vakenhetsgrad och forvirring.

Yrsel pa grund av blodtrycksfall da man hastigt reser sig upp, svindel, snabb puls, karlkramp, myrkrypningar, domningar, muskelkramper, ledvark, brost - och ryggsmartor, urineringsbesvar och inkontinens, impotens, synstorningar.

Sallsynta (forekommer hos fler an 1 patient av 10 000, men farre an 1 patient av 1 000):

Overkanslighetsreaktion med feber, hudutslag, svullnad och ibland blodtrycksfall, hudreaktion i samband med solbestralning, svimning, forsamrad njurfunktion, magtarmblodning, karlvaggsinflammation, inflammation i bukspottskorteln, gulsot. Sankta natriumnivaer i blodet. Blodbrist och andra forandringar i blodbilden t ex brist pa vita blodkroppar, sa kallad agranulocytos, se aven Var sarskilt forsiktig med Normorix och Normorix mite.

Mycket sallsynta (forekommer hos farre an 1 patient av 10 000):

Vatska i lungorna, buksmartor, hud - och slemhinneforandringar (ibland allvarliga).

Om nagra biverkningar blir varre eller om du marker nagra biverkningar som inte namns i denna information, kontakta lakare eller apotekspersonal.

5. HUR NORMORIX OCH NORMORIX MITE SKA FORVARAS Forvaras utom syn - och rackhall for barn.

Forvaras vid hogst 25°C.

Anvands fore utgangsdatum som anges pa etiketten efter Utg. dat. Utgangsdatumet ar den sista dagen i angiven manad.

Medicinen ska inte kastas i avloppet eller bland hushallsavfall. Fraga apotekspersonalen hur man gor med mediciner som inte langre anvands. Dessa atgarder ar till for att skydda miljon.

6. OVRIGA UPPLYSNINGAR Innehallsdeklaration - De aktiva substanserna ar amiloridklorid och hydroklortiazid.

- Normorix 5 mg/50 mg innehaller 5 mg amiloridhydroklorid i form av amiloridhydrokloriddihydrat och 50 mg hydroklortiazid.

- Normorix mite 2,5 mg/25 mg innehaller 2,5 mg amiloridhydroklorid i form av amiloridhydrokloriddihydrat och 25 mg hydroklortiazid.

- Ovriga innehallsamnen ar laktosmonohydrat 60 mg (Normorix) respektive 30 mg (Normorix mite), magnesiumstearat, povidon, mikrokristallin cellulosa, talk och risstarkelse.

Lakemedlets utseende och forpackningsstorlekar Normorix 5 mg/50 mg ar en vit till gulaktig, rund tablett med diameter 8 mm. Tabletten har brytskara och ar praglad med AB 71.

Normorix mite 2,5 mg/25 mg ar en vit till gulaktig, rund tablett med diameter 6 mm. Tabletten ar svagt konkav och ar praglad med AB 73.

30 respektive 100 tabletter i plastburk.

98 x 1 tabletter (endos) i blisterforpackning.

Eventuellt kommer inte alla forpackningsstorlekar att marknadsforas.

Innehavare av godkannande for forsaljning och tillverkare Nycomed AB

102 53 Stockholm

tel 08-731 28 00



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Zactos, Zactos

Zapdos is a legendary bird Pokemon that has the ability to control electricity. It usually lives in thunderclouds. The Pokemon gains power if it is stricken by lightning bolts.

Zapdos is a legendary bird Pokemon that has the ability to control electricity. It usually lives in thunderclouds. The Pokemon gains power if it is stricken by lightning bolts.

Versions:

Height 5' 03"

Weight 116.0 lbs

Gender Unknown

Close Ability Info

Pressure

The Pokemon raises opposing Pokemon's PP usage.

Type

Weaknesses

Evolutions

This Pokemon does not evolve.

Zapdos #145

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Zapdos's Pokémon TV Episodes

S11 | Episode 42

S19 | Episode 17

An Electrifying Rage!

S5 | Episode 33

As Clear as Crystal

S13 | Episode 16

Dealing with a Fierce Double Ditto Drama!

S1 | Episode 17

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Diclofenac - Woman S Health, Fenaren

Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis. Diclofenac may also be used for purposes other than those listed in this medication guide.

Use Diclofenac as directed by your doctor.

Take Diclofenac by mouth with or without food. Ask your health care provider any questions you may have about how to use Diclofenac.

Drug Class and Mechanism

Diclofenac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

If you miss a dose of Diclofenac, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Store Diclofenac at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do not use Diclofenac if:

you are allergic to any ingredient in Diclofenac; you have had a severe allergic reaction (e. g. severe rash, hives, breathing difficulties, dizziness) to another NSAID (e. g. ibuprofen, naproxen, celecoxib) or aspirin. Contact your doctor or health care provider right away if any of these apply to you.

Important : Diclofenac may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Before you start any new medicine, check the label to see if it has diclofenac or another nonsteroidal anti-inflammatory drug (NSAID) medicine in it too. If it does or if you are not sure, check with your doctor or pharmacist. Diclofenac should not be used in children; safety and effectiveness in children have not been confirmed. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breast-feed while using Diclofenac.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

burning or stinging; discharge; eye redness, irritation, or itching. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred or distorted vision; eye infection; eyelid swelling or redness; sensitivity to glare or light.

Diclofenac is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.



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Matlab Central - Matlab M-File, Lamdra

Matlab M-file

Walter Roberson <roberson@hushmail. com> wrote in message <7i4el.100418$zJ2.96015@newsfe23.iad>. > Matlab virgin Please help. -( wrote: > > xn+1=f(xn)=lamdra xn (1-xn) Please help me, I need the code for the m-file for the above equation, > > What is lamdra. Did you happen to mean the Greek character lambda, which usually > represents a constant? > > What is your initial condition? If x0 is 0 or 1, then xn would always be 0. > > If the task is to find the lambda that gives you the steady state, then the > answer is lambda = 1/(1-x0). lambda less than 2 decays to 0 over time, lambda > greater than 4 grows without bound over time, and values from 2 to 4 can > lead to infinite oscillations depending upon x0.

Thank you Walter, yes I meant Lambda, and that is the formula xn+1=f(xn)=lamdra xn (1-xn)

Where the function f(x) = lambda x (1-x) is the logistical mapping. Lamdra represents the effective growth rate with a restricted between 0:4

xn represents the population size using xn + 1 at the n^th year using (n+1)^th between 0:1

Should I go on? Or should I just give up? I am finding this really difficult but if I don't ask I will not learn or even understand, sorry to be a pain. x

> > -- >.signature note: I am now avoiding replying to unclear or ambiguous postings. > Please review questions before posting them. Be specific. Use examples of what you mean, > of what you don't mean. Specify boundary conditions, and data classes and value > relationships -- what if we scrambled your data or used - Inf, NaN, or complex(rand, rand)?

Matlab virgin Please help. -( wrote: > yes I meant Lambda, and that is the formula > xn+1=f(xn)=lamdra xn (1-xn)

Lambda = 2.81743; InitialPopulation = 0.139; NumRuns = 1000; xn = zeros(1,NumRuns); xn(1) = InitialPopulation; for K=2:length(xn); xn(K) = Lambda * xn(K-1) * (1-xn(K-1)); end; plot(xn);

--.signature note: I am now avoiding replying to unclear or ambiguous postings. Please review questions before posting them. Be specific. Use examples of what you mean, of what you don't mean. Specify boundary conditions, and data classes and value relationships -- what if we scrambled your data or used - Inf, NaN, or complex(rand, rand)?

"Matlab virgin Please help. -(" <kymberly2000@hotmail. co. uk> wrote in message news:glal0s$5qa$1@fred. mathworks. com. > Walter Roberson <roberson@hushmail. com> wrote in message > <7i4el.100418$zJ2.96015@newsfe23.iad>. >> Matlab virgin Please help. -( wrote: >> > xn+1=f(xn)=lamdra xn (1-xn) Please help me, I need the code for the >> > m-file for the above equation, >> >> What is lamdra. Did you happen to mean the Greek character lambda, which >> usually >> represents a constant? >> >> What is your initial condition? If x0 is 0 or 1, then xn would always be >> 0. >> >> If the task is to find the lambda that gives you the steady state, then >> the >> answer is lambda = 1/(1-x0). lambda less than 2 decays to 0 over time, >> lambda >> greater than 4 grows without bound over time, and values from 2 to 4 can >> lead to infinite oscillations depending upon x0. > > Thank you Walter, yes I meant Lambda, and that is the formula > xn+1=f(xn)=lamdra xn (1-xn) > > Where the function f(x) = lambda x (1-x) is the logistical mapping. Lamdra > represents the effective growth rate with a restricted between 0:4 > > xn represents the population size using xn + 1 at the n^th year using > (n+1)^th between 0:1 > > Should I go on? Or should I just give up? I am finding this really > difficult but if I don't ask I will not learn or even understand, sorry to > be a pain. x

Stop for a minute and take a deep breath.

Start at the beginning, not the middle or end.

As a first step, read through the entire Getting Started section of the documentation.

Yes, I know you have a specific task you want to accomplish. Yes, I know (or suspect) you're on a deadline. Yes, I know you want to jump right in and work on that task. But you need to get the basics down first. You wouldn't start building a house without taking the time to make sure the foundation is set, would you?

Read through the Getting Started guide (if you're not going to be writing GUIs or MEX-files right now, you can skip the "Creating Graphical User Interfaces" and "External Interfaces" sections until you do) and anywhere you see code, execute it and make sure you understand what it's doing. It probably won't take you that long.

Now you should have basic knowledge of how to:

1) Create a function M-file. 2) Create a matrix and populate it.

which are the skills you'll need to accomplish your specific task. Once you've gone through Getting Started and tried to create your function, if you have specific questions show your function and ask for help on it and you'll be much more likely to receive specific help.

-- Steve Lord slord@mathworks. com

Walter Roberson <roberson@hushmail. com> wrote in message <Yb5el.123883$H12.119488@newsfe12.iad>. > Matlab virgin Please help. -( wrote: > > yes I meant Lambda, and that is the formula > > xn+1=f(xn)=lamdra xn (1-xn) > > Trivial. > > Lambda = 2.81743; InitialPopulation = 0.139; NumRuns = 1000; > xn = zeros(1,NumRuns); xn(1) = InitialPopulation; > for K=2:length(xn); xn(K) = Lambda * xn(K-1) * (1-xn(K-1)); end; > plot(xn); > > > -- >.signature note: I am now avoiding replying to unclear or ambiguous postings. > Please review questions before posting them. Be specific. Use examples of what you mean, > of what you don't mean. Specify boundary conditions, and data classes and value > relationships -- what if we scrambled your data or used - Inf, NaN, or complex(rand, rand)?

Thank you Walter x

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Buy Online Matlab Central - Matlab M-File, Lamdra

Pioglitazone Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Nor Glitazon

pioglitazone

Warnings

Pioglitazone may rarely cause or worsen a certain heart problem (congestive heart failure ). Tell your doctor right away if you notice any symptoms of heart failure. including: swelling of the hands/feet, unusual/sudden weight gain. trouble breathing. unusual tiredness.

This medication is not recommended for people with certain types of heart failure. Before using this medication, tell your doctor if you have heart failure .

Uses

Pioglitazone is an anti-diabetic drug (thiazolidinedione-type, also called "glitazones") used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. It works by helping to restore your body's proper response to insulin. thereby lowering your blood sugar .

Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke .

Pioglitazone is used either alone or in combination with other anti-diabetic medications (such as metformin or a sulfonylurea such as glyburide ).

Talk to your doctor about the risks and benefits of pioglitazone.

How to use pioglitazone

Read the Medication Guide provided by your pharmacist before you start using pioglitazone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily. Dosage is based on your medical condition, response to treatment, and if you are taking other anti-diabetic drugs. Your doctor will adjust your dose based on your blood sugar levels to find the best dose for you. Follow your doctor's directions carefully.

Take this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day.

If you are already taking another anti-diabetic drug (such as metformin or a sulfonylurea), follow your doctor's directions carefully for stopping/continuing the old drug and starting this medication. Carefully follow the medication treatment plan, meal plan, and exercise program your doctor has recommended.

Check your blood sugar regularly as directed by your doctor. Keep track of the results, and share them with your doctor. Tell your doctor if your blood sugar measurements are too high or too low. Your dosage/treatment may need to be changed. It may take up to 2 to 3 months before the full benefit of this drug takes effect.

Side Effects

See also Warning section.

Sore throat. muscle pain. weight gain, or tooth problems may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: new/worsening vision problems (such as blurred vision ), bone fracture, reddish-colored urine, urgent need to urinate, pain while urinating.

Pioglitazone may rarely cause liver disease. Tell your doctor right away if you develop symptoms of liver disease, including: dark urine, yellowing of eyes /skin. persistent nausea /vomiting. stomach /abdominal pain .

Pioglitazone does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if this drug is prescribed with other anti-diabetic medications (such as insulin or a sulfonylurea). Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise. or do not consume enough calories from food. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.

Symptoms of low blood sugar include sudden sweating. shaking, fast heartbeat, hunger. blurred vision. dizziness. or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product.

Symptoms of high blood sugar (hyperglycemia ) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor right away. Your dosage may need to be increased.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking pioglitazone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (such as congestive heart failure, chest pain), liver disease, fluid in your lungs, swelling (edema), anemia, a certain eye problem (macular edema), bladder cancer.

You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

Limit alcohol while taking this medication because it can increase the risk of developing low blood sugar.

It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Consult your doctor because increased stress may require a change in your treatment plan, medications, or blood sugar testing.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Pioglitazone may increase the risk of bone fracture in women (usually in the upper arm, hand, or foot). See also Notes section.

Pioglitazone can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Consult your doctor or pharmacist about the use of reliable birth control while using this medication.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Your doctor may substitute insulin for this drug during your pregnancy. Follow all instructions carefully.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Other medications can affect the removal of pioglitazone from your body, which may affect how pioglitazone works. Examples include gemfibrozil, rifamycins including rifampin, among others.

Beta-blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are unaffected by these drugs.

Many drugs can affect your blood sugar levels, making it more difficult to control your blood sugar. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor about the results and of any symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your anti-diabetic medication, exercise program, or diet.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

You should attend a diabetes education program to learn more about diabetes and all the important aspects of its treatment, including meals/diet, exercise, personal hygiene, medications, and getting regular eye/foot/medical exams.

Lifestyle changes that help promote healthy bones include increasing weight-bearing exercise, eating well-balanced meals containing adequate calcium and vitamin D, stopping smoking, and limiting alcohol. Consult your doctor to see if you need to take calcium/vitamin D supplements and discuss lifestyle changes that might benefit you.

Keep all medical appointments. Laboratory and/or medical tests (such as liver function tests, blood glucose, hemoglobin A1c, complete blood counts, eye exams) should be performed periodically to check for side effects and monitor your response to treatment. Check your blood sugar levels regularly as directed.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Buy Online Pioglitazone Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Nor Glitazon

Tatig 50mg Tablets, Tatig

TATIG 50MG TABLETS

Transcript

(sertraline hydrochloride) Patient Information Leaflet Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. * Keep this leaflet. You may need to read it again. * If you have any further questions, ask your doctor or pharmacist. * This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. * If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. Your medicine is called Lustral 50mg Tablets but will be referred to as Lustral throughout this Patient Information Leaflet. Please note that the leaflet also contains information about other strengths of the medicine, Lustral 100mg. What is in this leaflet: 1 What Lustral is and what it is used for 2 What you need to know before you take Lustral 3 How to take Lustral 4 Possible side effects 5 How to store Lustral 6 Contents of the pack and other information

What Lustral is and what it is used for

Lustral contains the active substance sertraline. Sertraline is one of a group of medicines called Selective Serotonin Re-uptake Inhibitors (SSRIs); these medicines are used to treat depression and/or anxiety disorders. Lustral can be used to treat: * Depression and prevention of recurrence of depression (in adults). * Social anxiety disorder (in adults). * Post traumatic stress disorder (PTSD) (in adults). * Panic disorder (in adults). * Obsessive compulsive disorder (OCD) (in adults and children and adolescents aged 6-17 years old). Depression is a clinical illness with symptoms like feeling sad, unable to sleep properly or to enjoy life as you used to. OCD and Panic disorders are illnesses linked to anxiety with symptoms like being constantly troubled by persistent ideas (obsessions) that make you carry out repetitive rituals (compulsions). PTSD is a condition that can occur after a very emotionally traumatic experience, and has some symptoms that are similar to depression and anxiety. Social anxiety disorder (social phobia) is an illness linked to anxiety. It is characterised by feelings of intense anxiety or distress in social situations (for example: talking to strangers, speaking in front of groups of people, eating or drinking in front of others or worrying that you might behave in an embarrassing manner). Your doctor has decided that this medicine is suitable for treating your illness. You should ask your doctor if you are unsure why you have been given Lustral.

What you need to know before you take Lustral

Do not take Lustral: * If you are allergic to sertraline or any of the other ingredients of this medicine (listed in section 6). * If you are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs such as selegiline, moclobemide) or MAOI like drugs (such as linezolid). If you stop treatment with sertraline, you must wait until at least one week before you start treatment with a MAOI. After stopping treatment with a MAOI, you must wait at least 2 weeks before you can start treatment with sertraline. * If you are taking another medicine called pimozide (a medicine for mental disorders such as psychosis). Warnings and precautions Talk to your doctor or pharmacist before taking Lustral. Medicines are not always suitable for everyone. Tell your doctor before you take Lustral, if you suffer from or have suffered in the past from any of the following conditions: * If you have epilepsy (fit) or a history of seizures. If you have a fit (seizure), contact your doctor immediately. * If you have suffered from manic depressive illness (bipolar disorder) or schizophrenia. If you have a manic episode, contact your doctor immediately. * If you have or have previously had thoughts of harming or killing yourself (see below-Thoughts of suicide and worsening of your depression or anxiety disorder). * If you have Serotonin Syndrome. In rare cases this syndrome may occur when you are taking certain medicines at the same time as sertraline. (For symptoms, see section 4. Possible Side Effects). Your doctor will have told you whether you have suffered from this in the past. * If you have low sodium level in your blood, since this can occur as a result of treatment with Lustral. You should also tell your doctor if you are taking certain medicines for hypertension, since these medicines may also alter the sodium level in your blood. * If you are elderly as you may be more at risk of having low sodium level in your blood (see above). * If you have liver disease; your doctor may decide that you should have a lower dose of Lustral. * If you have diabetes; your blood glucose levels may be altered due to Lustral and your diabetes medicines may need to be adjusted. * If you have suffered from bleeding disorders or have been taking medicines which thin the blood (e. g. acetylsalicyclic acid (aspirin), or warfarin) or may increase the risk of bleeding. * If you are a child or adolescent under 18 years old. Lustral should only be used to treat children and adolescents aged 6-17 years old, suffering from obsessive compulsive disorder (OCD). If you are being treated for this disorder, your doctor will want to monitor you closely (see belowChildren and adolescents). * If you are having electro-convulsive therapy (ECT). * If you have eye problems, such as certain kinds of glaucoma (increased pressure in the eye). * If you have been told that you have an abnormality of your heart tracing after an electrocardiogram (ECG) known as prolonged QT interval. Restlessness/Akathisia: The use of sertraline has been linked to a distressing restlessness and need to move, often being unable to sit or stand still (akathisia). This is most likely to occur during the first few weeks of treatment. Increasing the dose may be harmful so if you develop such symptoms you should talk to your doctor. Withdrawal reactions: Side effects relating to stopping treatment (withdrawal reactions) are common, particularly if the treatment is stopped suddenly (see section 3 If you stop taking Lustral and section 4 Possible side effects). The risk of withdrawal symptoms depends on the length of treatment, dosage, and the rate at which the dose is reduced. Generally, such symptoms are mild to moderate. However, they can be serious in some patients. They normally occur within the first few days after stopping treatment. In general, such symptoms disappear on their own and wear off within 2 weeks. In some patients they may last longer (2-3 months or more). When stopping treatment with sertraline it is recommended to reduce the dose gradually over a period of several weeks or months, and you should always discuss the best way of stopping treatment with your doctor.

Thoughts of suicide and worsening of your depression or anxiety disorder: If you are depressed and/or have anxiety disorders you can sometimes have thoughts of harming or killing yourself. These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer. You may be more likely to think like this: * If you have previously had thoughts about killing or harming yourself. * If you are a young adult. Information from clinical trials has shown an increased risk of suicidal behaviour in adults aged less than 25 years with psychiatric conditions who were treated with an antidepressant. If you have thoughts of harming or killing yourself at any time, contact your doctor or go to a hospital straight away. You may find it helpful to tell a relative or close friend that you are depressed or have an anxiety disorder, and ask them to read this leaflet. You might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behaviour. Children and adolescents: Sertraline should not usually be used in children and adolescents less than 18 years old, except for patients with Obsessive Compulsive Disorder (OCD). Patients under 18 have an increased risk of undesirable effects, such as suicide attempt, thoughts of harming or killing themselves (suicidal thoughts) and hostility (mainly aggressiveness, oppositional behaviour and anger) when they are treated with this class of medicines. Nevertheless, it is possible that your doctor decides to prescribe Lustral to a patient under 18 if it is in the patient’s interest. If your doctor has prescribed Lustral to you and you are less than 18 years old and you want to discuss this, please contact him/her. Furthermore, if any of the symptoms listed above appear or worsen while you are taking Lustral, you should inform your doctor. Also, the longterm safety of Lustral in regard to growth, maturation and learning (cognitive) and behavioural development in this age group has not yet been demonstrated. Other medicines and Lustral: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Some medicines can affect the way Lustral works, or Lustral itself can reduce the effectiveness of other medicines taken at the same time. Taking Lustral together with the following medicines may cause serious side effects: * Medicines called monoamine oxidase inhibitors (MAOIs), like moclobemide (to treat depression) and selegiline (to treat Parkinson’s disease), the antibiotic linezolid and methylene blue (to treat high levels of methaemoglobin in the blood). Do not use Lustral together with these medicines. * Medicines to treat mental disorders such as psychosis (pimozide). Do not use Lustral together with pimozide. Talk to your doctor if you are taking the following medicines: * Herbal medicine containing St. John’s Wort (Hypericum perforatum). The effects of St. John’s Wort may last for 1-2 weeks. * Products containing the amino acid tryptophan. * Medicines to treat severe pain (e. g. tramadol). * Medicines used in anaesthesia or to treat chronic pain (fentanyl, mivacurium and suxamethonium). * Medicines to treat migraines (e. g. sumatriptan). * Blood thinning medicine (warfarin). * Medicines to treat pain/arthritis (Non steroidal anti-inflammatory drug (NSAID) such as ibuprofen, acetylsalicylic acid (aspirin)). * Sedatives (diazepam). * Diuretics (also called ‘water’ tablets). * Medicines to treat epilepsy (phenytoin, phenobarbital, carbamazepine). * Medicines to treat diabetes (tolbutamide). * Medicines to treat excessive stomach acid, ulcers and heartburn (cimetidine, omeprazole, lanzoprazole, pantoprazole, rabeprazole). * Medicines to treat mania and depression (lithium). * Other medicines to treat depression (such as amitriptyline, nortriptyline, nefazodone, fluoxetine, fluvoxamine). * Medicines to treat schizophrenia and other mental disorders (such as perphenazine, levomepromazine and olanzapine). * Medicines used to treat high blood pressure, chest pain or regulate the rate and rhythm of the heart (such as verapamil, diltiazem, flecainide, propafenone). * Medicines used to treat bacterial infections (such as rifampicin, clarithromycin, telithromycin, erythromycin). * Medicines used to treat fungal infections (such as ketoconazole, itraconazole, posaconazole, voriconazole, fluconazole). * Medicines used to treat HIV/AIDS and Hepatitis C (protease inhibitors such as ritonavir, telaprevir). * Medicines used to prevent nausea and vomiting after an operation or chemotherapy (aprepitant). * Medicines known to increase the risk of changes in the electrical activity of the heart (e. g. some antipsychotics and antibiotics). Lustral with food, drink and alcohol: Lustral tablets can be taken with or without food. Alcohol should be avoided whilst taking Lustral. Sertraline should not be taken in combination with grapefruit juice, as this may increase the level of sertraline in your body. Pregnancy, breast-feeding and fertility: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. The safety of sertraline has not fully been established in pregnant women. Sertraline will only be given to you when pregnant if your doctor considers that the benefit for you is greater than any possible risk to the developing baby. If you are a woman capable of having children you should use a reliable method of contraception (such as the contraceptive pill), when taking sertraline. Make sure your midwife and/or doctor know you are on Lustral. When taken during pregnancy, particularly in the last 3 months of pregnancy, medicines like Lustral may increase the risk of a serious condition in babies, called persistent pulmonary hypertension of the newborn (PPHN), making the baby breathe faster and appear bluish. These symptoms usually begin during the first 24 hours after the baby is born. If this happens to your baby you should contact your midwife and/or doctor immediately. Your newborn baby might also have other conditions, which usually begin during the first 24 hours after birth. Symptoms include: * trouble with breathing, * a blueish skin or being too hot or cold, * blue lips, * vomiting or not feeding properly, * being very tired, not able to sleep or crying a lot, * stiff or floppy muscles, * tremors, jitters or fits, * increased reflex reactions, * irritability, * low blood sugar. If your baby has any of these symptoms when it is born, or you are concerned about your baby’s health, contact your doctor or midwife who will be able to advise you. There is evidence that sertraline passes into human breast milk. Sertraline should only be used in women during breast-feeding, if your doctor considers that the benefit exceeds any possible risk to the baby. Some medicines like sertraline may reduce the quality of sperm in animal studies. Theoretically, this could affect fertility, but impact on human fertility has not been observed as yet. Driving and using machines: Psychotropic drugs such as sertraline may influence your ability to drive or use machines. You should therefore not drive or operate machinery, until you know how this medication affects your ability to perform these activities.

Lustral 50mg Tablets ®

(sertraline hydrochloride) 3

How to take Lustral

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. The recommended dose is: Adults: Depression and Obssessive Compulsive Disorder For depression and OCD, the usual effective dose is 50 mg/day. The daily dose may be increased in 50 mg increments and at intervals of at least one week over a period of weeks. The maximum recommended dose is 200 mg/day. Panic disorder, Social anxiety disorder and Post Traumatic Stress Disorder: For panic disorder, social anxiety disorder and post traumatic stress disorder, treatment should be started at 25 mg/day, and increased to 50 mg/day after one week. The daily dose then may be increased in 50 mg increments over a period of weeks. The maximum recommended dose is 200 mg/day. Use in children and adolescents: Lustral must only be used to treat children and adolescents suffering from OCD aged 6-17 years old. Obsessive Compulsive Disorder: Children aged 6 to 12: the recommended starting dose is 25 mg daily. After one week, your doctor may increase this to 50 mg daily. The maximum dose is 200 mg daily. Adolescents aged 13 to 17: the recommended starting dose is 50 mg daily. The maximum dose is 200 mg daily. If you have liver or kidney problems, please tell your doctor and follow the doctor’s instructions. Method of administration: Lustral tablets may be taken with or without food. Take your medication once daily either in the morning or evening. Your doctor will advise you on how long to take this medication for. This will depend on the nature of your illness and how well you are responding to the treatment. It may take several weeks before your symptoms begin to improve. Treatment of depression should usually continue for 6 months after improvement. If you take more Lustral than you should: If you accidentally take too much Lustral contact your doctor at once or go to the nearest hospital casualty department. Always take the labelled medicine package with you, whether there is any medication left or not. Symptoms of overdose may include drowsiness, nausea and vomiting, rapid heart rate, shaking, agitation, dizziness and in rare cases unconsciousness. If you forget to take Lustral: Do not take a double dose to make up for a forgotten dose. If you forget to take a dose, do not take the missed dose. Just take the next dose at the right time. If you stop taking Lustral: Do not stop taking Lustral unless your doctor tells you to. Your doctor will want to gradually reduce your dose of Lustral over several weeks, before you finally stop taking this medicine. If you suddenly stop taking this medicine you may experience side effects such as dizziness, numbness, sleep disturbances, agitation or anxiety, headaches, feeling sick, being sick and shaking. If you experience any of these side effects, or any other side effects whilst stopping taking Lustral, please speak to your doctor. If you have any further questions on the use of this product, ask your doctor or pharmacist.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Nausea is the most common side effect. The side effects depend on the dose and often disappear or lessen with continued treatment. Tell your doctor immediately: If you experience any of the following symptoms after taking this medicine, these symptoms can be serious. you develop a severe skin rash that causes blistering (erythema * Ifmultiforme), (this can affect the mouth and tongue). These may be signs of a condition known as Stevens Johnson Syndrome, or Toxic Epidermal Necrolysis (TEN). Your doctor will stop your treatment in these cases. Allergic reaction or allergy, which may include symptoms such as an itchy * skin rash, breathing problems, wheezing, swollen eyelids, face or lips. you experience agitation, confusion, diarrhoea, high temperature and * Ifblood pressure, excessive sweating and rapid heartbeat. These are symptoms of Serotonin Syndrome. In rare cases this syndrome may occur when you are taking certain medicines at the same time as sertraline. Your doctor may wish to stop your treatment. develop yellow skin and eyes which may mean liver damage. * IfIf you you experience depressive symptoms with ideas of harming or killing * yourself (suicidal thoughts). start to get feelings of restlessness and are not able to sit or stand * Ifstillyouafter you start to take Lustral. You should tell your doctor if you start to feel restless. have a fit (seizure). * IfIf you * you have a manic episode (see section 2 “Warnings and precautions”). The following side effects were seen in clinical trials in adults. Very common (may affect more than 1 in 10 people): Insomnia, dizziness, sleepiness, headache, diarrhoea, feeling sick, dry mouth, ejaculation failure, fatigue. Common (may affect up to 1 in 10 people): throat, anorexia, increased appetite, * Sore feeling strange, nightmare, anxiety, agitation, nervousness, * depression, decreased sexual interest, teeth grinding, and tingling, shaking, muscle tense, abnormal taste, lack of * numbness attention, disturbance, ringing in ears, * visual hot flush, yawning, * palpitations, pain, vomiting, constipation, upset stomach, gas, * abdominal increased sweating, muscle pain, erectile dysfunction, chest pain * rash, pain, * joint * malaise. Uncommon (may affect up to 1 in 100 people): cold, runny nose, * Chest * hypersensitivity, thyroid hormones, * low feeling too happy, lack of caring, thinking abnormal, * hallucination, aggression, involuntary muscle contractions, abnormal coordination, * convulsion, moving a lot, amnesia, decreased feeling, speech disorder, dizziness while standing up, passing out, migraine, pupils, * enlarged pain, fast heartbeat, high blood pressure, flushing, * ear difficulty, possible wheezing, shortness of breath, nose bleed, * breathing of the oesophagus, difficulty swallowing, haemorrhoids, * inflammation increased saliva, tongue disorder, burping, swelling, purple spots on skin, face oedema, hair loss, cold sweat, dry * eye skin, hives, itching, muscular weakness, back pain, muscle twitching, * osteoarthritis, urination, unable to urinate, increase in urination, increase in * nighttime frequency of urination, problem urinating, urinary incontinence,

haemorrhage, sexual dysfunction, female sexual dysfunction, * vaginal menstrual irregularities, swelling in legs, chills, fever, weakness, thirst, increase in liver enzyme levels, weight decreased, weight increased. Rare (may affect up to 1 in 1,000 people): problem, ear infection, cancer, swollen glands, high cholesterol, * Intestine low blood sugar, symptoms due to stress or emotions, drug dependence, psychotic * physical disorder, paranoia, suicidal thoughts, sleep walking, premature ejaculation, allergic reaction, * severe abnormal movements, difficulty moving, increased sensation, * coma, sensory disturbance, tear problem, spots in front of eyes, double vision, light * glaucoma, hurts eye, blood in the eye, problems controlling blood sugar levels (diabetes), * heart attack, slow heart beat, heart problem, poor circulation of arms and * legs, closing up of throat, breathing fast, breathing slow, difficulty talking, hiccups, in stool, sore mouth, tongue ulceration, tooth disorder, tongue * blood problem, mouth ulceration, problems with liver function, problem with blisters, hair rash, hair texture abnormal, skin odour * skin abnormal, bone disorder, urination, urinary hesitation, blood in urine, * decreased vaginal bleeding, dry vaginal area, red painful penis and * excessive foreskin, genital discharge, prolonged erection, breast discharge, hernia, tolerance decreased, difficulty walking, semen abnormal, * increasedrug in blood cholesterol levels, injury, relaxation of blood vessels procedure, of suicidal ideation and suicidal behaviours have been * Cases reported during sertraline therapy or early after treatment discontinuation (see section 2). After marketing sertraline, the following side effects have been reported: in white blood cells, decrease in clotting cells, endocrine * Decrease problem, low blood salt, increase in blood sugar levels, abnormal dreams, suicidal behaviour, * terrifying muscular movement problems (such as moving a lot, tense muscles, * difficulty walking and stiffness, spasms and involuntary movements of muscles), sudden severe headache (which may be a sign of a serious condition known as Reversible Cerebral Vasoconstriction Syndrome (RCVS)), abnormal, unequal sized pupils, bleeding problems (such as * vision stomach bleeding), progressive scarring of lung tissue (Interstitial Lung Disease), pancreatitis, serious liver function problems, yellow skin and eyes (jaundice), oedema, skin reaction to sun, muscle cramps, breast enlargement, * skin problems with clotting, abnormal laboratory tests, bedwetting. fainting, or chest discomfort which could be signs * Light-headedness, of changes in the electrical activity (seen on electrocardiogram) or abnormal rhythm of the heart. Additional side effects in children and adolescents In clinical trials with children and adolescents, the side effects were generally similar to adults (see above). The most common side effects in children and adolescents were headache, insomnia, diarrhoea and feeling sick. Symptoms that can occur when treatment is discontinued If you suddenly stop taking this medicine you may experience side effects such as dizziness, numbness, sleep disturbances, agitation or anxiety, headaches, feeling sick, being sick and shaking (see section 3. “If you stop taking Lustral”). An increased risk of bone fractures has been observed in patients taking this type of medicines. Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly (see details below). By reporting side effects you can help provide more information on the safety of this medicine. United Kingdom Yellow Card Scheme website: www. mhra. gov. uk/yellowcard 5

How to store Lustral

Expiry date Do not use this medicine after the expiry date shown on the carton label or blister strip. If your doctor tells you to stop taking this medicine, return any unused tablets to your pharmacist for safe disposal. Only keep this medicine, if your doctor tells you to. If your tablets become discoloured or show any other signs of deterioration, consult your pharmacist who will tell you what to do. Storing your medicine OUT OF THE SIGHT AND REACH OF CHILDERN * KEEP not take your tablets out of the blister strip until it is time to take your * Do dose. Important Remember this medicine is for you. Only a doctor can prescribe it. Never give your medicine to other people. It may harm them, even if their symptoms are the same as yours. This leaflet does not tell you everything about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist. He/she will have additional information about this medicine and will be able to advise you.

Contents of the pack and other information

What Lustral contains Each tablet contains sertraline hydrochloride equivalent to 50mg sertraline as the active ingredient. Other ingredients: calcium hydrogen phosphate, microcrystalline cellulose, hydroxypropylcellulose, sodium starch glycollate, magnesium stearate, titanium dioxide (E171), macrogol 400, macrogol 6000, polysorbate-80, hypromellose E3, hypromellose E5. What Lustral looks like and contents of the pack Lustral are white, capsular shaped film-coated scored tablets coded with ‘ZLT-50’ on one side and ‘PFIZER’ on the other side. Each blister pack contains 15 tablets and comes in boxes of 30 tablets. Manufacturer and Licence Holder The tablets are manufactured by Haupt Pharma Latina S. r.l. S. S. 156, Km 47, 600, Borgo San Michele, 04100 Latina, Italy and are procured from within the EU and repackaged by the Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE. If you have any questions or are not sure about anything, ask your doctor or pharmacist. They will have additional information about this medicine and will be able to advise you.

Lustral is a registered trademark of Pfizer Products Inc. Revision date: 15/07/16

Blind or partially sighted? Is this leaflet hard to see or read? Phone Lexon (UK) Limited, Tel: 01527 505414 for help.

(sertraline hydrochloride) Patient Information Leaflet Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. * Keep this leaflet. You may need to read it again. * If you have any further questions, ask your doctor or pharmacist. * This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. * If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. Your medicine is called Tatig 50mg Tablets but will be referred to as Tatig throughout this Patient Information Leaflet. Please note that the leaflet also contains information about other strengths of the medicine, Tatig 100mg. What is in this leaflet: 1 What Tatig is and what it is used for 2 What you need to know before you take Tatig 3 How to take Tatig 4 Possible side effects 5 How to store Tatig 6 Contents of the pack and other information

What Tatig is and what it is used for

Tatig contains the active substance sertraline. Sertraline is one of a group of medicines called Selective Serotonin Re-uptake Inhibitors (SSRIs); these medicines are used to treat depression and/or anxiety disorders. Tatig can be used to treat: * Depression and prevention of recurrence of depression (in adults). * Social anxiety disorder (in adults). * Post traumatic stress disorder (PTSD) (in adults). * Panic disorder (in adults). * Obsessive compulsive disorder (OCD) (in adults and children and adolescents aged 6-17 years old). Depression is a clinical illness with symptoms like feeling sad, unable to sleep properly or to enjoy life as you used to. OCD and Panic disorders are illnesses linked to anxiety with symptoms like being constantly troubled by persistent ideas (obsessions) that make you carry out repetitive rituals (compulsions). PTSD is a condition that can occur after a very emotionally traumatic experience, and has some symptoms that are similar to depression and anxiety. Social anxiety disorder (social phobia) is an illness linked to anxiety. It is characterised by feelings of intense anxiety or distress in social situations (for example: talking to strangers, speaking in front of groups of people, eating or drinking in front of others or worrying that you might behave in an embarrassing manner). Your doctor has decided that this medicine is suitable for treating your illness. You should ask your doctor if you are unsure why you have been given Tatig.

What you need to know before you take Tatig

Do not take Tatig: * If you are allergic to sertraline or any of the other ingredients of this medicine (listed in section 6). * If you are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs such as selegiline, moclobemide) or MAOI like drugs (such as linezolid). If you stop treatment with sertraline, you must wait until at least one week before you start treatment with a MAOI. After stopping treatment with a MAOI, you must wait at least 2 weeks before you can start treatment with sertraline. * If you are taking another medicine called pimozide (a medicine for mental disorders such as psychosis). Warnings and precautions Talk to your doctor or pharmacist before taking Tatig. Medicines are not always suitable for everyone. Tell your doctor before you take Tatig, if you suffer from or have suffered in the past from any of the following conditions: * If you have epilepsy (fit) or a history of seizures. If you have a fit (seizure), contact your doctor immediately. * If you have suffered from manic depressive illness (bipolar disorder) or schizophrenia. If you have a manic episode, contact your doctor immediately. * If you have or have previously had thoughts of harming or killing yourself (see below-Thoughts of suicide and worsening of your depression or anxiety disorder). * If you have Serotonin Syndrome. In rare cases this syndrome may occur when you are taking certain medicines at the same time as sertraline. (For symptoms, see section 4. Possible Side Effects). Your doctor will have told you whether you have suffered from this in the past. * If you have low sodium level in your blood, since this can occur as a result of treatment with Tatig. You should also tell your doctor if you are taking certain medicines for hypertension, since these medicines may also alter the sodium level in your blood. * If you are elderly as you may be more at risk of having low sodium level in your blood (see above). * If you have liver disease; your doctor may decide that you should have a lower dose of Tatig. * If you have diabetes; your blood glucose levels may be altered due to Tatig and your diabetes medicines may need to be adjusted. * If you have suffered from bleeding disorders or have been taking medicines which thin the blood (e. g. acetylsalicyclic acid (aspirin), or warfarin) or may increase the risk of bleeding. * If you are a child or adolescent under 18 years old. Tatig should only be used to treat children and adolescents aged 6-17 years old, suffering from obsessive compulsive disorder (OCD). If you are being treated for this disorder, your doctor will want to monitor you closely (see belowChildren and adolescents). * If you are having electro-convulsive therapy (ECT). * If you have eye problems, such as certain kinds of glaucoma (increased pressure in the eye). * If you have been told that you have an abnormality of your heart tracing after an electrocardiogram (ECG) known as prolonged QT interval. Restlessness/Akathisia: The use of sertraline has been linked to a distressing restlessness and need to move, often being unable to sit or stand still (akathisia). This is most likely to occur during the first few weeks of treatment. Increasing the dose may be harmful so if you develop such symptoms you should talk to your doctor. Withdrawal reactions: Side effects relating to stopping treatment (withdrawal reactions) are common, particularly if the treatment is stopped suddenly (see section 3 If you stop taking Tatig and section 4 Possible side effects). The risk of withdrawal symptoms depends on the length of treatment, dosage, and the rate at which the dose is reduced. Generally, such symptoms are mild to moderate. However, they can be serious in some patients. They normally occur within the first few days after stopping treatment. In general, such symptoms disappear on their own and wear off within 2 weeks. In some patients they may last longer (2-3 months or more). When stopping treatment with sertraline it is recommended to reduce the dose gradually over a period of several weeks or months, and you should always discuss the best way of stopping treatment with your doctor.

Thoughts of suicide and worsening of your depression or anxiety disorder: If you are depressed and/or have anxiety disorders you can sometimes have thoughts of harming or killing yourself. These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer. You may be more likely to think like this: * If you have previously had thoughts about killing or harming yourself. * If you are a young adult. Information from clinical trials has shown an increased risk of suicidal behaviour in adults aged less than 25 years with psychiatric conditions who were treated with an antidepressant. If you have thoughts of harming or killing yourself at any time, contact your doctor or go to a hospital straight away. You may find it helpful to tell a relative or close friend that you are depressed or have an anxiety disorder, and ask them to read this leaflet. You might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behaviour. Children and adolescents: Sertraline should not usually be used in children and adolescents less than 18 years old, except for patients with Obsessive Compulsive Disorder (OCD). Patients under 18 have an increased risk of undesirable effects, such as suicide attempt, thoughts of harming or killing themselves (suicidal thoughts) and hostility (mainly aggressiveness, oppositional behaviour and anger) when they are treated with this class of medicines. Nevertheless, it is possible that your doctor decides to prescribe Tatig to a patient under 18 if it is in the patient’s interest. If your doctor has prescribed Tatig to you and you are less than 18 years old and you want to discuss this, please contact him/her. Furthermore, if any of the symptoms listed above appear or worsen while you are taking Tatig, you should inform your doctor. Also, the long-term safety of Tatig in regard to growth, maturation and learning (cognitive) and behavioural development in this age group has not yet been demonstrated. Other medicines and Tatig: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Some medicines can affect the way Tatig works, or Tatig itself can reduce the effectiveness of other medicines taken at the same time. Taking Tatig together with the following medicines may cause serious side effects: * Medicines called monoamine oxidase inhibitors (MAOIs), like moclobemide (to treat depression) and selegiline (to treat Parkinson’s disease), the antibiotic linezolid and methylene blue (to treat high levels of methaemoglobin in the blood). Do not use Tatig together with these medicines. * Medicines to treat mental disorders such as psychosis (pimozide). Do not use Tatig together with pimozide. Talk to your doctor if you are taking the following medicines: * Herbal medicine containing St. John’s Wort (Hypericum perforatum). The effects of St. John’s Wort may last for 1-2 weeks. * Products containing the amino acid tryptophan. * Medicines to treat severe pain (e. g. tramadol). * Medicines used in anaesthesia or to treat chronic pain (fentanyl, mivacurium and suxamethonium). * Medicines to treat migraines (e. g. sumatriptan). * Blood thinning medicine (warfarin). * Medicines to treat pain/arthritis (Non steroidal anti-inflammatory drug (NSAID) such as ibuprofen, acetylsalicylic acid (aspirin)). * Sedatives (diazepam). * Diuretics (also called ‘water’ tablets). * Medicines to treat epilepsy (phenytoin, phenobarbital, carbamazepine). * Medicines to treat diabetes (tolbutamide). * Medicines to treat excessive stomach acid, ulcers and heartburn (cimetidine, omeprazole, lanzoprazole, pantoprazole, rabeprazole). * Medicines to treat mania and depression (lithium). * Other medicines to treat depression (such as amitriptyline, nortriptyline, nefazodone, fluoxetine, fluvoxamine). Medicines to treat schizophrenia and other mental disorders (such as * perphenazine, levomepromazine and olanzapine). * Medicines used to treat high blood pressure, chest pain or regulate the rate and rhythm of the heart (such as verapamil, diltiazem, flecainide, propafenone). * Medicines used to treat bacterial infections (such as rifampicin, clarithromycin, telithromycin, erythromycin). * Medicines used to treat fungal infections (such as ketoconazole, itraconazole, posaconazole, voriconazole, fluconazole). * Medicines used to treat HIV/AIDS and Hepatitis C (protease inhibitors such as ritonavir, telaprevir). * Medicines used to prevent nausea and vomiting after an operation or chemotherapy (aprepitant). * Medicines known to increase the risk of changes in the electrical activity of the heart (e. g. some antipsychotics and antibiotics). Tatig with food, drink and alcohol: Tatig tablets can be taken with or without food. Alcohol should be avoided whilst taking Tatig. Sertraline should not be taken in combination with grapefruit juice, as this may increase the level of sertraline in your body. Pregnancy, breast-feeding and fertility: If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. The safety of sertraline has not fully been established in pregnant women. Sertraline will only be given to you when pregnant if your doctor considers that the benefit for you is greater than any possible risk to the developing baby. If you are a woman capable of having children you should use a reliable method of contraception (such as the contraceptive pill), when taking sertraline. Make sure your midwife and/or doctor know you are on Tatig. When taken during pregnancy, particularly in the last 3 months of pregnancy, medicines like Tatig may increase the risk of a serious condition in babies, called persistent pulmonary hypertension of the newborn (PPHN), making the baby breathe faster and appear bluish. These symptoms usually begin during the first 24 hours after the baby is born. If this happens to your baby you should contact your midwife and/or doctor immediately. Your newborn baby might also have other conditions, which usually begin during the first 24 hours after birth. Symptoms include: * trouble with breathing, * a blueish skin or being too hot or cold, * blue lips, * vomiting or not feeding properly, * being very tired, not able to sleep or crying a lot, * stiff or floppy muscles, * tremors, jitters or fits, * increased reflex reactions, * irritability, * low blood sugar. If your baby has any of these symptoms when it is born, or you are concerned about your baby’s health, contact your doctor or midwife who will be able to advise you. There is evidence that sertraline passes into human breast milk. Sertraline should only be used in women during breast-feeding, if your doctor considers that the benefit exceeds any possible risk to the baby. Some medicines like sertraline may reduce the quality of sperm in animal studies. Theoretically, this could affect fertility, but impact on human fertility has not been observed as yet. Driving and using machines: Psychotropic drugs such as sertraline may influence your ability to drive or use machines. You should therefore not drive or operate machinery, until you know how this medication affects your ability to perform these activities.

(sertraline hydrochloride) 3

How to take Tatig

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. The recommended dose is: Adults: Depression and Obssessive Compulsive Disorder For depression and OCD, the usual effective dose is 50 mg/day. The daily dose may be increased in 50 mg increments and at intervals of at least one week over a period of weeks. The maximum recommended dose is 200 mg/day. Panic disorder, Social anxiety disorder and Post Traumatic Stress Disorder: For panic disorder, social anxiety disorder and post traumatic stress disorder, treatment should be started at 25 mg/day, and increased to 50 mg/day after one week. The daily dose then may be increased in 50 mg increments over a period of weeks. The maximum recommended dose is 200 mg/day. Use in children and adolescents: Tatig must only be used to treat children and adolescents suffering from OCD aged 6-17 years old. Obsessive Compulsive Disorder: Children aged 6 to 12: the recommended starting dose is 25 mg daily. After one week, your doctor may increase this to 50 mg daily. The maximum dose is 200 mg daily. Adolescents aged 13 to 17: the recommended starting dose is 50 mg daily. The maximum dose is 200 mg daily. If you have liver or kidney problems, please tell your doctor and follow the doctor’s instructions. Method of administration: Tatig tablets may be taken with or without food. Take your medication once daily either in the morning or evening. Your doctor will advise you on how long to take this medication for. This will depend on the nature of your illness and how well you are responding to the treatment. It may take several weeks before your symptoms begin to improve. Treatment of depression should usually continue for 6 months after improvement. If you take more Tatig than you should: If you accidentally take too much Tatig contact your doctor at once or go to the nearest hospital casualty department. Always take the labelled medicine package with you, whether there is any medication left or not. Symptoms of overdose may include drowsiness, nausea and vomiting, rapid heart rate, shaking, agitation, dizziness and in rare cases unconsciousness. If you forget to take Tatig: Do not take a double dose to make up for a forgotten dose. If you forget to take a dose, do not take the missed dose. Just take the next dose at the right time. If you stop taking Tatig: Do not stop taking Tatig unless your doctor tells you to. Your doctor will want to gradually reduce your dose of Tatig over several weeks, before you finally stop taking this medicine. If you suddenly stop taking this medicine you may experience side effects such as dizziness, numbness, sleep disturbances, agitation or anxiety, headaches, feeling sick, being sick and shaking. If you experience any of these side effects, or any other side effects whilst stopping taking Tatig, please speak to your doctor. If you have any further questions on the use of this product, ask your doctor or pharmacist.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Nausea is the most common side effect. The side effects depend on the dose and often disappear or lessen with continued treatment. Tell your doctor immediately: If you experience any of the following symptoms after taking this medicine, these symptoms can be serious. you develop a severe skin rash that causes blistering (erythema * Ifmultiforme), (this can affect the mouth and tongue). These may be signs of a condition known as Stevens Johnson Syndrome, or Toxic Epidermal Necrolysis (TEN). Your doctor will stop your treatment in these cases. Allergic reaction or allergy, which may include symptoms such as an itchy * skin rash, breathing problems, wheezing, swollen eyelids, face or lips. you experience agitation, confusion, diarrhoea, high temperature and * Ifblood pressure, excessive sweating and rapid heartbeat. These are symptoms of Serotonin Syndrome. In rare cases this syndrome may occur when you are taking certain medicines at the same time as sertraline. Your doctor may wish to stop your treatment. develop yellow skin and eyes which may mean liver damage. * IfIf you you experience depressive symptoms with ideas of harming or killing * yourself (suicidal thoughts). start to get feelings of restlessness and are not able to sit or stand * Ifstillyouafter you start to take Tatig. You should tell your doctor if you start to feel restless. have a fit (seizure). * IfIf you * you have a manic episode (see section 2 “Warnings and precautions”). The following side effects were seen in clinical trials in adults. Very common (may affect more than 1 in 10 people): Insomnia, dizziness, sleepiness, headache, diarrhoea, feeling sick, dry mouth, ejaculation failure, fatigue. Common (may affect up to 1 in 10 people): throat, anorexia, increased appetite, * Sore feeling strange, nightmare, anxiety, agitation, nervousness, * depression, decreased sexual interest, teeth grinding, and tingling, shaking, muscle tense, abnormal taste, lack of * numbness attention, disturbance, ringing in ears, * visual hot flush, yawning, * palpitations, pain, vomiting, constipation, upset stomach, gas, * abdominal increased sweating, muscle pain, erectile dysfunction, chest pain * rash, pain, * joint * malaise. Uncommon (may affect up to 1 in 100 people): cold, runny nose, * Chest * hypersensitivity, thyroid hormones, * low feeling too happy, lack of caring, thinking abnormal, * hallucination, aggression, involuntary muscle contractions, abnormal coordination, * convulsion, moving a lot, amnesia, decreased feeling, speech disorder, dizziness while standing up, passing out, migraine, pupils, * enlarged pain, fast heartbeat, high blood pressure, flushing, * ear difficulty, possible wheezing, shortness of breath, nose bleed, * breathing of the oesophagus, difficulty swallowing, haemorrhoids, * inflammation increased saliva, tongue disorder, burping, swelling, purple spots on skin, face oedema, hair loss, cold sweat, dry * eye skin, hives, itching, muscular weakness, back pain, muscle twitching, * osteoarthritis, urination, unable to urinate, increase in urination, increase in * nighttime frequency of urination, problem urinating, urinary incontinence,

haemorrhage, sexual dysfunction, female sexual dysfunction, * vaginal menstrual irregularities, swelling in legs, chills, fever, weakness, thirst, increase in liver enzyme levels, weight decreased, weight increased. Rare (may affect up to 1 in 1,000 people): problem, ear infection, cancer, swollen glands, high cholesterol, * Intestine low blood sugar, symptoms due to stress or emotions, drug dependence, psychotic * physical disorder, paranoia, suicidal thoughts, sleep walking, premature ejaculation, allergic reaction, * severe abnormal movements, difficulty moving, increased sensation, * coma, sensory disturbance, tear problem, spots in front of eyes, double vision, light * glaucoma, hurts eye, blood in the eye, problems controlling blood sugar levels (diabetes), * heart attack, slow heart beat, heart problem, poor circulation of arms and * legs, closing up of throat, breathing fast, breathing slow, difficulty talking, hiccups, in stool, sore mouth, tongue ulceration, tooth disorder, tongue * blood problem, mouth ulceration, problems with liver function, problem with blisters, hair rash, hair texture abnormal, skin odour * skin abnormal, bone disorder, urination, urinary hesitation, blood in urine, * decreased vaginal bleeding, dry vaginal area, red painful penis and * excessive foreskin, genital discharge, prolonged erection, breast discharge, hernia, tolerance decreased, difficulty walking, semen abnormal, * increasedrug in blood cholesterol levels, injury, relaxation of blood vessels procedure, of suicidal ideation and suicidal behaviours have been * Cases reported during sertraline therapy or early after treatment discontinuation (see section 2). After marketing sertraline, the following side effects have been reported: in white blood cells, decrease in clotting cells, endocrine * Decrease problem, low blood salt, increase in blood sugar levels, abnormal dreams, suicidal behaviour, * terrifying muscular movement problems (such as moving a lot, tense muscles, * difficulty walking and stiffness, spasms and involuntary movements of muscles), sudden severe headache (which may be a sign of a serious condition known as Reversible Cerebral Vasoconstriction Syndrome (RCVS)), abnormal, unequal sized pupils, bleeding problems (such as * vision stomach bleeding), progressive scarring of lung tissue (Interstitial Lung Disease), pancreatitis, serious liver function problems, yellow skin and eyes (jaundice), oedema, skin reaction to sun, muscle cramps, breast enlargement, * skin problems with clotting, abnormal laboratory tests, bedwetting. fainting, or chest discomfort which could be signs * Light-headedness, of changes in the electrical activity (seen on electrocardiogram) or abnormal rhythm of the heart. Additional side effects in children and adolescents In clinical trials with children and adolescents, the side effects were generally similar to adults (see above). The most common side effects in children and adolescents were headache, insomnia, diarrhoea and feeling sick. Symptoms that can occur when treatment is discontinued If you suddenly stop taking this medicine you may experience side effects such as dizziness, numbness, sleep disturbances, agitation or anxiety, headaches, feeling sick, being sick and shaking (see section 3. “If you stop taking Tatig”). An increased risk of bone fractures has been observed in patients taking this type of medicines. Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly (see details below). By reporting side effects you can help provide more information on the safety of this medicine. United Kingdom Yellow Card Scheme website: www. mhra. gov. uk/yellowcard 5

How to store Tatig

Expiry date Do not use this medicine after the expiry date shown on the carton label or blister strip. If your doctor tells you to stop taking this medicine, return any unused tablets to your pharmacist for safe disposal. Only keep this medicine, if your doctor tells you to. If your tablets become discoloured or show any other signs of deterioration, consult your pharmacist who will tell you what to do. Storing your medicine OUT OF THE SIGHT AND REACH OF CHILDERN * KEEP not take your tablets out of the blister strip until it is time to take your * Do dose. Important Remember this medicine is for you. Only a doctor can prescribe it. Never give your medicine to other people. It may harm them, even if their symptoms are the same as yours. This leaflet does not tell you everything about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist. He/she will have additional information about this medicine and will be able to advise you.

Contents of the pack and other information

What Tatig contains Each tablet contains sertraline hydrochloride equivalent to 50mg sertraline as the active ingredient. Other ingredients: calcium hydrogen phosphate, microcrystalline cellulose, hydroxypropylcellulose, sodium starch glycollate, magnesium stearate, titanium dioxide (E171), macrogol 400, macrogol 6000, polysorbate-80, hypromellose E3, hypromellose E5. What Tatig looks like and contents of the pack Tatig are white, capsular shaped film-coated scored tablets coded with ‘ZLT-50’ on one side and ‘PFIZER’ on the other side. Each blister pack contains 15 tablets and comes in boxes of 30 tablets. Manufacturer and Licence Holder The tablets are manufactured by Haupt Pharma Latina S. r.l. S. S. 156, Km 47, 600, Borgo San Michele, 04100 Latina, Italy and are procured from within the EU and repackaged by the Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE. If you have any questions or are not sure about anything, ask your doctor or pharmacist. They will have additional information about this medicine and will be able to advise you.

Tatig is a registered trademark of Pfizer Products Inc. Revision date: 15/07/16

Blind or partially sighted? Is this leaflet hard to see or read? Phone Lexon (UK) Limited, Tel: 01527 505414 for help.

Sertraline ® 50mg Tablets

(sertraline hydrochloride) Patient Information Leaflet Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. * Keep this leaflet. You may need to read it again. * If you have any further questions, ask your doctor or pharmacist. * This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. * If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. Your medicine is called Sertraline 50mg Tablets but will be referred to as Sertraline throughout this Patient Information Leaflet. Please note that the leaflet also contains information about other strengths of the medicine, Sertraline 100mg. What is in this leaflet 1 What Sertraline is and what it is used for 2 What you need to know before you take Sertraline 3 How to take Sertraline 4 Possible side effects 5 How to store Sertraline 6 Contents of the pack and other information

What Sertraline is and what it is used for

Sertraline contains the active substance sertraline. Sertraline is one of a group of medicines called Selective Serotonin Re-uptake Inhibitors (SSRIs); these medicines are used to treat depression and/or anxiety disorders. Sertraline can be used to treat: * Depression and prevention of recurrence of depression (in adults). * Social anxiety disorder (in adults). * Post traumatic stress disorder (PTSD) (in adults). * Panic disorder (in adults). * Obsessive compulsive disorder (OCD) (in adults and children and adolescents aged 6-17 years old). Depression is a clinical illness with symptoms like feeling sad, unable to sleep properly or to enjoy life as you used to. OCD and Panic disorders are illnesses linked to anxiety with symptoms like being constantly troubled by persistent ideas (obsessions) that make you carry out repetitive rituals (compulsions). PTSD is a condition that can occur after a very emotionally traumatic experience, and has some symptoms that are similar to depression and anxiety. Social anxiety disorder (social phobia) is an illness linked to anxiety. It is characterised by feelings of intense anxiety or distress in social situations (for example: talking to strangers, speaking in front of groups of people, eating or drinking in front of others or worrying that you might behave in an embarrassing manner). Your doctor has decided that this medicine is suitable for treating your illness. You should ask your doctor if you are unsure why you have been given Sertraline.

What you need to know before you take Sertraline

Do not take Sertraline: * If you are allergic to sertraline or any of the other ingredients of this medicine (listed in section 6). * If you are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs such as selegiline, moclobemide) or MAOI like drugs (such as linezolid). If you stop treatment with sertraline, you must wait until at least one week before you start treatment with a MAOI. After stopping treatment with a MAOI, you must wait at least 2 weeks before you can start treatment with sertraline. * If you are taking another medicine called pimozide (a medicine for mental disorders such as psychosis). Warnings and precautions Talk to your doctor or pharmacist before taking Sertraline. Medicines are not always suitable for everyone. Tell your doctor before you take Sertraline, if you suffer from or have suffered in the past from any of the following conditions: * If you have epilepsy (fit) or a history of seizures. If you have a fit (seizure), contact your doctor immediately. * If you have suffered from manic depressive illness (bipolar disorder) or schizophrenia. If you have a manic episode, contact your doctor immediately. * If you have or have previously had thoughts of harming or killing yourself (see below-Thoughts of suicide and worsening of your depression or anxiety disorder). * If you have Serotonin Syndrome. In rare cases this syndrome may occur when you are taking certain medicines at the same time as sertraline. (For symptoms, see section 4. Possible Side Effects). Your doctor will have told you whether you have suffered from this in the past. * If you have low sodium level in your blood, since this can occur as a result of treatment with Sertraline. You should also tell your doctor if you are taking certain medicines for hypertension, since these medicines may also alter the sodium level in your blood. * If you are elderly as you may be more at risk of having low sodium level in your blood (see above). * If you have liver disease; your doctor may decide that you should have a lower dose of Sertraline. * If you have diabetes; your blood glucose levels may be altered due to Sertraline and your diabetes medicines may need to be adjusted. * If you have suffered from bleeding disorders or have been taking medicines which thin the blood (e. g. acetylsalicyclic acid (aspirin), or warfarin) or may increase the risk of bleeding. * If you are a child or adolescent under 18 years old. Sertraline should only be used to treat children and adolescents aged 6-17 years old, suffering from obsessive compulsive disorder (OCD). If you are being treated for this disorder, your doctor will want to monitor you closely (see belowChildren and adolescents). * If you are having electro-convulsive therapy (ECT). * If you have eye problems, such as certain kinds of glaucoma (increased pressure in the eye). * If you have been told that you have an abnormality of your heart tracing after an electrocardiogram (ECG) known as prolonged QT interval. Restlessness/Akathisia: The use of sertraline has been linked to a distressing restlessness and need to move, often being unable to sit or stand still (akathisia). This is most likely to occur during the first few weeks of treatment. Increasing the dose may be harmful so if you develop such symptoms you should talk to your doctor. Withdrawal reactions: Side effects relating to stopping treatment (withdrawal reactions) are common, particularly if the treatment is stopped suddenly (see section 3 If you stop taking Sertraline and section 4 Possible side effects). The risk of withdrawal symptoms depends on the length of treatment, dosage, and the rate at which the dose is reduced. Generally, such symptoms are mild to moderate. However, they can be serious in some patients. They normally occur within the first few days after stopping treatment. In general, such symptoms disappear on their own and wear off within 2 weeks. In some patients they may last longer (2-3 months or more). When stopping treatment with sertraline it is recommended to reduce the dose gradually over a period of several weeks or months, and you should always discuss the best way of stopping treatment with your doctor.

Thoughts of suicide and worsening of your depression or anxiety disorder: If you are depressed and/or have anxiety disorders you can sometimes have thoughts of harming or killing yourself. These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer. You may be more likely to think like this: * If you have previously had thoughts about killing or harming yourself. * If you are a young adult. Information from clinical trials has shown an increased risk of suicidal behaviour in adults aged less than 25 years with psychiatric conditions who were treated with an antidepressant. If you have thoughts of harming or killing yourself at any time, contact your doctor or go to a hospital straight away. You may find it helpful to tell a relative or close friend that you are depressed or have an anxiety disorder, and ask them to read this leaflet. You might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behaviour. Children and adolescents: Sertraline should not usually be used in children and adolescents less than 18 years old, except for patients with Obsessive Compulsive Disorder (OCD). Patients under 18 have an increased risk of undesirable effects, such as suicide attempt, thoughts of harming or killing themselves (suicidal thoughts) and hostility (mainly aggressiveness, oppositional behaviour and anger) when they are treated with this class of medicines. Nevertheless, it is possible that your doctor decides to prescribe Sertraline to a patient under 18 if it is in the patient’s interest. If your doctor has prescribed Sertraline to you and you are less than 18 years old and you want to discuss this, please contact him/her. Furthermore, if any of the symptoms listed above appear or worsen while you are taking Sertraline, you should inform your doctor. Also, the long-term safety of Sertraline in regard to growth, maturation and learning (cognitive) and behavioural development in this age group has not yet been demonstrated. Other medicines and Sertraline: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Some medicines can affect the way Sertraline works, or Sertraline itself can reduce the effectiveness of other medicines taken at the same time. Taking Sertraline together with the following medicines may cause serious side effects: * Medicines called monoamine oxidase inhibitors (MAOIs), like moclobemide (to treat depression) and selegiline (to treat Parkinson’s disease), the antibiotic linezolid and methylene blue (to treat high levels of methaemoglobin in the blood). Do not use Sertraline together with these medicines. * Medicines to treat mental disorders such as psychosis (pimozide). Do not use Sertraline together with pimozide. Talk to your doctor if you are taking the following medicines: * Herbal medicine containing St. John’s Wort (Hypericum perforatum). The effects of St. John’s Wort may last for 1-2 weeks. * Products containing the amino acid tryptophan. * Medicines to treat severe pain (e. g. tramadol). * Medicines used in anaesthesia or to treat chronic pain (fentanyl, mivacurium and suxamethonium). * Medicines to treat migraines (e. g. sumatriptan). * Blood thinning medicine (warfarin). * Medicines to treat pain/arthritis (Non steroidal anti-inflammatory drug (NSAID) such as ibuprofen, acetylsalicylic acid (aspirin)). * Sedatives (diazepam). * Diuretics (also called ‘water’ tablets). * Medicines to treat epilepsy (phenytoin, phenobarbital, carbamazepine). * Medicines to treat diabetes (tolbutamide). * Medicines to treat excessive stomach acid, ulcers and heartburn (cimetidine, omeprazole, lanzoprazole, pantoprazole, rabeprazole). * Medicines to treat mania and depression (lithium). * Other medicines to treat depression (such as amitriptyline, nortriptyline, nefazodone, fluoxetine, fluvoxamine). Medicines to treat schizophrenia and other mental disorders (such as * perphenazine, levomepromazine and olanzapine). * Medicines used to treat high blood pressure, chest pain or regulate the rate and rhythm of the heart (such as verapamil, diltiazem, flecainide, propafenone). * Medicines used to treat bacterial infections (such as rifampicin, clarithromycin, telithromycin, erythromycin). * Medicines used to treat fungal infections (such as ketoconazole, itraconazole, posaconazole, voriconazole, fluconazole). * Medicines used to treat HIV/AIDS and Hepatitis C (protease inhibitors such as ritonavir, telaprevir). * Medicines used to prevent nausea

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Apo-Propranolol - Uses, Side Effects, Interactions, Apo-Propranolol

Apo-Propranolol

How does this medication work? What will it do for me?

Propranolol belongs to the class of medications called beta-blockers . It is used to treat high blood pressure . It is also used to prevent angina (chest pain), to reduce the risk of more heart problems after a heart attack (myocardial infarction), to manage certain heart conditions, and to treat certain types of abnormal heart rhythms. Propranolol works by relaxing blood vessels and reducing the demands on the heart.

Propranolol is also used for the prevention of migraines and the treatment of essential tremor.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

10 mg Each round, orange, biconvex tablet, scored and identified "APO" over "10" on one side, contains propranolol HCl 10 mg. Nonmedicinal ingredients: cornstarch, D&C Yellow No. 10 Aluminum Lake, FD&C Yellow No. 6, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.

20 mg Each hexagonal, blue, biconvex tablet, scored and identified "APO" over "20" on one side, contains propranolol HCl 20 mg. Nonmedicinal ingredients: cornstarch, FD&C Blue No. 1 Aluminum Lake, FD&C Blue No. 2 Aluminum Lake, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.

40 mg Each round, green, biconvex tablet, scored and identified "APO" over "40" on one side, contains propranolol HCl 40 mg. Nonmedicinal ingredients: cornstarch, croscarmellose sodium, D&C Yellow No. 10 Aluminum Lake, FD&C Blue No. 2 Aluminum Lake, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.

80 mg Each round, yellow, biconvex tablet, scored and identified "APO" over "80" on one side, contains propranolol HCl 80 mg. Nonmedicinal ingredients: colloidal silicon dioxide, cornstarch, croscarmellose sodium, D&C Yellow No. 10 Aluminum Lake, FD&C Yellow No. 6, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.

120 mg Each round, deep rose, biconvex tablet, scored and identified "APO" over "120" on one side, contains propranolol HCl 120 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and red ferric oxide.

How should I use this medication?

The recommended adult dose of propranolol varies widely according to the condition being treated and circumstances of the person taking the medication. Propranolol may be taken with or without food. Do not stop taking this medication suddenly unless you have talked with your doctor first.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"

Do not dispose of medications in wastewater (e. g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Propranolol should not be taken by anyone who:

is allergic to propranolol or to any of the ingredients of the medication

is in cardiogenic shock

has a severely slow heart rate

has allergic rhinitis during the pollen season

has asthma or severe chronic obstructive respiratory diseases (e. g. emphysema, chronic bronchitis)

has overt heart failure

has right ventricular failure secondary to pulmonary hypertension (excessive blood pressure in the lungs)

has serious heart block (second - and third-degree AV block)

has severe circulatory disorders

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

dizziness or lightheadedness

drowsiness (slight)

hives

itching of skin

skin rash

unusual tiredness or weakness

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

back or joint pain

breathing difficulty or wheezing

chest pain

cold hands and feet

confusion

depression

dizziness upon arising (orthostatic hypotension)

fever and sore throat

hallucinations

irregular heartbeat

red, scaling, or crusted skin

shortness of breath

slow heartbeat (especially less than 50 beats per minute)

skin rash

swelling of ankles, feet, or lower legs

unusual bleeding or bruising

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Breathing problems: People with asthma and certain other breathing problems should not take propranolol.

Congestive heart failure: People with congestive heart failure should not take propranolol.

Diabetes: The signs of low blood sugar may not be as noticeable when taking propranolol. People with diabetes who take insulin or other medications that work by reducing the sugar in the blood should be cautious and monitor blood sugar carefully while taking this medication.

Dizziness: Move slowly when moving from a lying down or sitting position to a standing position as dizziness may occur, especially when this medication is first being started.

Hyperthyroidism (high level of thyroid hormones): People with hyperthyroidism should be cautious while taking propranolol as it may reduce the symptoms of this condition giving a false impression of improvement. Stopping the medication suddenly could worsen this condition.

Severe allergies: People with allergies severe enough to cause anaphylaxis (a severe allergic reaction where swelling of the face, lips, and throat make it difficult to breathe) should talk to their doctor about what to do if they have an allergic reaction. Propranolol may make it more difficult to treat their allergic reaction with epinephrine.

Stopping medication: Propranolol should not be stopped suddenly by people who are taking it to treat angina. There have been reports of severe worsening of angina and of heart attack or abnormal heart rhythms occurring for people with angina pectoris who have stopped the medication abruptly.

Surgery: If you are scheduled for surgery, inform all doctors involved in your care that you take propranolol.

Pregnancy: Not enough information exists on the safe use of propranolol by pregnant women. Propranolol should be used during pregnancy only if the potential benefits justify the potential risks.

Breast-feeding: Propranolol passes into breast milk. Talk to your doctor about the risks and benefits of using this medication while breast-feeding.

Children: There is limited experience in the use of propranolol by children. Caution is advised with its use by this age group.

What other drugs could interact with this medication?

There may be an interaction between propranolol and any of the following:

amiodarone

antiarrhythmic medications

antidiabetes medications (e. g. insulin)

asthma medications (e. g. salbutamol, salmeterol)

calcium channel blockers (e. g. nifedipine, verapamil)

chlorpromazine

cimetidine

clonidine

digoxin

diltiazem

disopyramide

dong quai

epinephrine

ergot alkaloids (e. g. dihydroergotamine, methysergide)

fentanyl

haloperidol

hydralazine

lidocaine

medications that reduce blood pressure

mefloquine

methimazole

methyldopa

nonsteroidal anti-inflammatory drugs (NSAIDs; e. g. ibuprofen, naproxen)

prazosin

propafenone

quinidine

ranitidine

selective serotonin reuptake inhibitors(SSRIs; e. g. citalopram, fluoxetine, fluvoxamine paroxetine, sertraline)

St. John's wort

theophyllines (e. g. theophylline, aminophylline, oxtriphylline)

thioridazine

verapamil

warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,

change one of the medications to another,

change how you are taking one or both of the medications, or

leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.



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Deoxys - Pokemon Wiki, Dioxis

Deoxys

Another Deoxys appeared in the episode "Cheers On Castaways Island! ", where it transformed into a stone after struck by a thunderbolt. Near the end, it transformed back into Deoxys and protected Ash, Brock, Dawn, the Corphish and the Mantyke from the meteors that dropped down as it attacked Jessie's Yanmega.

Movies

Deoxys appeared in the movie Destiny Deoxys where the purple one tried to free the green egg trapped on the meteorite, however it was attacked by Rayquaza after being mistaken as an intruder for trespassing in its territory. They eventually had a duel somewhere in the arctic where a group of researchers witness the fierce battle between the two, as Deoxys was about to attack, the electrical surge shielded Rayquaza from its vision, giving Rayquaza the opportunity to regain strength, finally Rayquaza manage to defeat Deoxys and fly back into space, while the green egg in the meteorite was brought along by the researchers.

Four years later, the purple Deoxys had fully healed and track down its friend to LaRousse City, it causes a blackout to the entire city and remove all of the city's inhabitants in order to fulfill its search for its friend, however Rayquaza sensed its presence and headed to LaRousse City, Deoxys created a shield around the city, but Rayquaza found a way in and defeated all of the Deoxys clones. Ash and the others were able to provide enough amount of energy to revive the green egg, which hatched into the green Deoxys. The green Deoxys tried to stop the conflict, however the city's security system became haywire and attacked Rayquaza, the two Deoxys helped to defend Rayquaza, however they were overrun by the security robots, luckily Ash was able to deactivate the robot leader using the ID card, Rayquaza now convinced that they weren't intruders flies back to space, the Deoxys bids a farewell to everyone and leaves for space.

Trivia

Deoxys is one of the only Pokemon to have nearly identical Pokedex entries in every game in which it appears.

It is one of the strongest Pokemon, having the 504+ of Speed (As Speed Form), Attack, and Special Attack (as Attack Form), and is capable of overwhelming many Pokemon.

Deoxys' speed form was called Flight Form when it was first released.

Deoxys' speed form was not originally intended to be released and was only a last-minute addition for Emerald. This is evident by the fact that its original three forms (Defense, Normal, and Attack) can be put into order so that the first letter of each form can spell out DNA, which Deoxys is based off. But there is also a hint with the Speed Form. The "S" in Speed also refers to the S at the end of Deoxys, because DNA spells out Deoxy ribonucleic acid, where the "S" comes after Deoxy.

Although Deoxys was first obtainable in FireRed and LeafGreen. it is the last Pokemon in the Hoenn Pokedex.

Any part of Deoxys which is damaged will regenerate, as seen in the movie.

Deoxys appears in a Pokemon Dream World minigame; going into space high enough will cause Deoxys to appear out of nowhere and disappear.

Deoxys is the first and only Mythical and Event-exclusive Pokemon to be caught without the need of and event item (in Omega Ruby and Alpha Sapphire only). This makes it lose it's status as an Event-exclusive Pokemon.

Prior to Generation VI, it was an event-exclusive Pokemon, and could not be legitimately encountered in any of the main series games otherwise.

During the events of the Delta Episode of Omega Ruby and Alpha Sapphire. Deoxys intentionally changes the direction of the meteor it is traveling on midflight, and sets a new course for the Hoenn Region, thus prompting Zinnia to seek the help of Rayquaza. Its reasons for changing its course are unclear, but it is later speculated by a scientist in Mossdeep City that it was not out of ill intent on Deoxys' part.

Deoxys was given out in the U. S. Japan and Europe as movie event Pokemon, as well as a Gamestop event Pokemon in the U. S. Deoxys can also learn most of the TM moves, making it one of the most powerful Legendary Pokemon to date. It is a versatile, powerful Pokemon, learning a vast variety of moves specializing in all kinds of stats.

A glitch will occur if using a Gameshark to capture Deoxys past the event - when going to catch it a Missingno will pop up, but will have the cry of a Deoxys, as proven in Pokemon Emerald.

Wild Deoxys are always in the Normal Forme.

In Omega Ruby/Alpha Sapphire if you go to Fallarbor and enter the house of the Scientist with Deoxys in your party you can change the form by bringing it closer to the meteorite it will change forms to become the Attack Form, Defensive Form, Speed Form and back to normal again.

Eytmology

The name is derived from the D in D NA ( Deoxy ribonucleic Acid), to which Deoxys looks like a strand of DNA, has an unusual capability to regenerate its damaged parts and it can multiply itself like a strand of DNA.

Gallery



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American Century Strat Allc Agrsv Fd (Astax), Astax

American Century Strat Allc: Agrsv Fd

About ASTAX

The investment seeks the highest level of total return consistent with its asset mix. The fund's asset allocation strategy diversifies investments among equity securities, bonds and money market instruments. It usually invests 79% of its assets in stocks, 20% of its assets in bonds, and 1% of its assets in cash equivalents. The fund also invests in a variety of debt securities payable in U. S. and foreign currencies. It may invest in any type of U. S. or foreign equity security that meets certain fundamental and technical standards. The fund may invest up to 10% of its assets in below investment-grade securities.

Rankings

U. S. News evaluated 438 Allocation--70% to 85% Equity Funds. Our list highlights the top-rated funds for long-term investors based on the ratings of leading fund industry researchers.

Scorecard

Trailing Total Returns Monthly

Morningstar Mod Tgt Risk TR USD

Performance

The fund has returned -3.30 percent over the past year, 5.43 percent over the past three years, 5.59 percent over the past five years, and 4.83 percent over the past decade.

Fees

Fees are Above Average compared to funds in the same category. American Century Strat Allc: Agrsv Fd has an expense ratio of 2.13 percent.

Net Expense Ratio



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Buspar Side Effects, Ratings, And Patient Comments, Brispar

Drug Ratings for BUSPAR

Took 71/2 mgs for years dr upped it to 30 mg. insomnia 3 days. Sweating. Tight neck aching shoulders terrible anxiety heart pounding tingling. in hand. My guess is he upped it too fast. Decreased it to 5 mg in the morning. I feel the dr wasn't thinking when he upped it so fast. Was on the higher dose one week at the higher dose then all these symptoms started happening.

Feel better with the lower dose as it leaves your system fadt

Anxiety and withdrawal from ativan

Slight dizziness, mild sleepiness, mild headache. But no more obsessive thoughts. I was obsessing about obsessing!

I would very much appreciate it if reviews include your dosage. Thanks.

Yellow watery diarrhea, undigested food in stool, nausea, increased weight gain, loss of appetite, increased hunger, malnutrition, edema legs arms back shoulders, stiff tight muscles, fatigue, vision loss / degradation of visual focus acuity, mild dizziness.

Now, I know some of you will read my side effects and say, "Wow, what an idiot! Why didn't she stop taking the meds. " Because onset was slow, and vaguely noticeable until I ran out of metamucil. Heh? See? Yep, missed the early signs until it was too late. 2 weeks after stopping buspar, am on blood pressure meds to induce excretion of liquid buildup/edema in muscles. I can move again and have energy. My anxiety is a little worse, but frankly I would rather be tightly wound and cognizant, than fatigued and apathetic. May work for some, not for me. Will be sticking to Wellbutrin until my current psych prescribes me something more effective.

5 months 10mg 2/d

Anxiety/Panic add on to SSRI

Dry throat, ringing in ears, severe neck stiffness like your head feels like a bowling ball, headaches brain zaps, teeth clenching

I have been on benzos before and this was an add on to 25mg Zoloft and to .5 klonopin. As soon as I went down to 5mg the headaches eased up, I can still crack my neck daily, i am only one week off of 2.5mg and am having withdrawals, heart palps and diarrhea. I came looking for others in my situation. For me it was merely a pill I was taking that gave side effects. Now to push through it leaving.

No side effects

Never did I imagine that Buspar would work so well. I have tried many things for my panic attacks, which was a daily battle. Buspar was added partly to boost the lexpro I had been on for a few years and partly the hope of relieving panic/worry. It made such an incredible difference I was really in shock. Everything I read made is seem like it wouldn't do much. But for me it was a miracle.

1 years 10 mg 2X D

I was taking Buspar for anxiety. My anxiety is cause by bipolar disorder. I had bad reaction to it. I an adverse reaction to it. I was pacing back and forth for no reason. I was extremely emotional. I started to go into hypomania. This medicine does help allot people. But if you have bipolar disorder. It may trigger manic episodes. Please keep in touch with your doctor while taking it? It doesn't have adverse affects to all bipolar disorder. But in some cases it does. I know the feeling I had was horrible.

2 months 30mg a day

Increased anxiety, extreme restlessness, rapid heartbeat, insomnia, head/body tingles, flu like symptoms, chills

I hate it. Be warned this stuff isn't as innocuous as doctors make it out to be. And you absolutely CAN have withdrawal symptoms, so watch out for that.

Anxiety from synthyroid medication

Have been chomping my teeth stopped day 2 days ago and still doing it. I was not sleeping but couple hours a night, throat was swelling it was hard to swallow food and throat had gotten sore.

I am taking hydroxyzine 25mg there times a day. How long will these side effects last?

Extreme munchies and calming effect after 30 mintues of taking. Last maybe and hour. But I love this medicine. It's changed my life. I can actually enjoy it. I have extreme depression and anxiety. I have tried lots of other depression medicine. This one is the best.

Worsened depression and anxietySleepiness, headaches, fatigue, nausea, I NEEDED to be around people all the time (I became extremely clingy to everyone around me)

I was told that I wouldn't experience symptoms yet I did. It made my anxiety and depression so much worse and improved absolutely nothing. I was supposed to take 2 pills a day but they always made me pass out an hour after taking it. I had to constantly be around people (I'm naturally a loner) so I would go to public place just to be around people even though I didn't know them. I am underweight, so maybe I should have stuck with a smaller dose of this medication.

For 1 week when I first started taking it: insomnia For 1 month when I first started taking it: dizziness Side effects now: intensifies effect of caffeine

I love buspar - it reduces my anxiety without making me feel different in any way. No side effects whatsoever after the first month, except that if I drink coffee within 1 hour of taking a pill, it makes the coffee stronger - like I just had 2 cups instead of 1 cup.

Very fatigued, very increased blood pressure, nausea, neck pain, anxiety, depression and flu like symptoms.

Very bad side effects. Gave it a shot for 3 weeks but finally couldn't take it anymore. Actually I thought it would get a little better with each passing day but it got worse each day. It may work well for somebody else but this drug really stinks as far as I'm concerned. 2 days off and feeling a little more normal. The GAD is still here but the side effects of this drug make my GAD look like a walk in the park on a sunny day vs. the bad side effects of this drug.

3 weeks 15MG 3X D

Anxiety & panic attacks

I didn't have any until Dec 2015.I was having more nervous problems, sweating, headaches, nausea, etc. the more I took it. Been off of it for a week. Having withdrawal symptoms. Don't know what I can take in place of it. Sleeping problems r worse.

Anxiety, bad thoughts, trouble sleeping

At first I felt good and I didn't know if it was the Medline just knowing there was something on board that calmed me but I had trouble sleeping and anxiety as I kept taking it. Then I had a bad thought about hurting my husband and immediately stopped taking it. I have never been so scared of a thought in my life it sent me into a full blown body shaking anxiety attack. Ugh I hate this

9 days 5mg 2x a d

Irritabity, anxiety from Wellbutrin

Increased anxiety, near panic attacks, overly sensitive/emotional

Definitely made a bad decision to start this medication before taking a vacation. Ruined what should have been a relaxing trip..turned into me feeling very anxious and emotional

Blood pressure dropped to dangerously low level. Felt extremely dizzy and irritable. Also had rigidity of muscles in my neck along with feelings of detached emotional state.

Although I was on very low dose side effects nearly disabling.

I have had heart palpitations feeling anxious and irritable but because of some of the post that I've seen on here that I need to give it longer

I would really like to see the people put the manufacturer on here mine is Mylan. I had took buspar before for one week and couldn't even tell that I was taking anything it was a different manufacturer I can't remember the name but this one I could tell the same day big difference between the two manufacturers so I might try to call pharmacy to find out manufacture of the one I took before to see if that help if I took it for about a monththere's a lot of difference in the manufacture

9 days 5 milligra

Bloating, stomach pain, paranoia and agoraphobia. Dizzyness, disorientation, light sensitivity. Nausea before and after meals.

I started on five mg twice a day. I had some side effects but the only one that bothered me was shaking and nervousness as each dose wore off. Once I increased to ten mg the shaking stopped but I became increasingly paranoid and my stomach started to react to everything I ate. I went back and forth between diahrea and constipation, sometimes in the same day. The bloating and acid reflux were the worst. It made me look like I was pregnant. All in all it does not work for me. I have historically had bad reactions to medications like this and so I was really hoping this would work for me. But it doesn't. I am stepping down on my own before my check up appointment because it is effecting my ability to do my job. I also am a very physically active person and I haven't been able to run for three weeks because my discomfort is so great. I expect based on other reviews that it will take about a month to really reverse all of my symptoms while I step down gradually as is recommended. Note, I do not recommend stepping down on your own, unless you know how to do so safely, and seeing a doctor as soon as possible once you choose to do so is highly recommended.

4 weeks 10 mg x2

Rapid heart beat increase of panic attacks an change in blood pressure

Would like to kno how long it takes these side effects to wear off after only taking it once

panic attacks, general anxiety

It took a few days to get used to. I felt a little lightheaded/nervous for maybe 4 or 5 days. I recently started having some dry mouth. Least amount of symptoms I've had for an anxiety drug.

I've always had anxiety, and I've taken medication in the past, however, I hadn't been on medication for 4 or 5 years because I had my anxiety under control, until a few months ago. I started developing panic attacks and my anxiety in general got worse. Buspar has helped a lot after just 3 weeks. I no longer get shaky or irregular heart palpitations during the day. I'm feeling more positive overall. Good first impression.

3 weeks 10 MG 2X D



Buy Online Buspar Side Effects, Ratings, And Patient Comments, Brispar

Motrin - Pain Relief, Rimofen

Motrin is used for treating rheumatoid arthritis, osteoarthritis, menstrual cramps, or mild to moderate pain. Motrin is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Motrin as directed by your doctor.

Take Motrin by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Motrin with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Motrin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Motrin .

Store Motrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Motrin out of the reach of children and away from pets.

Active Ingredient: Ibuprofen.

Do NOT use Motrin if:

you are allergic to any ingredient in Motrin

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Motrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, lupus, asthma, or growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse.

Some medicines may interact with Motrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Probenecid because it may increase the risk of Motrin 's side effects

Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Motrin

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Motrin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Motrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Motrin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Motrin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Motrin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Motrin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Motrin has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Motrin unless your doctor tells you to.

Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Use Motrin with caution in the elderly; they may be more sensitive to its effects, including stomach bleeding and kidney problems.

Motrin should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Motrin may cause harm to the fetus. Do not take it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Motrin while you are pregnant. It is not known if Motrin is found in breast milk. Do not breastfeed while taking Motrin .

All medicines can cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Motrin is used for treating rheumatoid arthritis, osteoarthritis, menstrual cramps, or mild to moderate pain. Motrin is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Motrin as directed by your doctor.

Take Motrin by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Motrin with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Motrin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Motrin .

Store Motrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Motrin out of the reach of children and away from pets.

Active Ingredient: Ibuprofen.

Do NOT use Motrin if:

you are allergic to any ingredient in Motrin

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Motrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, lupus, asthma, or growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse.

Some medicines may interact with Motrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Probenecid because it may increase the risk of Motrin 's side effects

Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Motrin

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Motrin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Motrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Motrin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Motrin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Motrin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Motrin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Motrin has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Motrin unless your doctor tells you to.

Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Use Motrin with caution in the elderly; they may be more sensitive to its effects, including stomach bleeding and kidney problems.

Motrin should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Motrin may cause harm to the fetus. Do not take it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Motrin while you are pregnant. It is not known if Motrin is found in breast milk. Do not breastfeed while taking Motrin .

All medicines can cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Motrin is used for treating rheumatoid arthritis, osteoarthritis, menstrual cramps, or mild to moderate pain. Motrin is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Motrin as directed by your doctor.

Take Motrin by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Motrin with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Motrin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Motrin .

Store Motrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Motrin out of the reach of children and away from pets.

Active Ingredient: Ibuprofen.

Do NOT use Motrin if:

you are allergic to any ingredient in Motrin

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Motrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, lupus, asthma, or growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse.

Some medicines may interact with Motrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Probenecid because it may increase the risk of Motrin 's side effects

Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Motrin

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Motrin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Motrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Motrin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Motrin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Motrin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Motrin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Motrin has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Motrin unless your doctor tells you to.

Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Use Motrin with caution in the elderly; they may be more sensitive to its effects, including stomach bleeding and kidney problems.

Motrin should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Motrin may cause harm to the fetus. Do not take it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Motrin while you are pregnant. It is not known if Motrin is found in breast milk. Do not breastfeed while taking Motrin .

All medicines can cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



Buy Online Motrin - Pain Relief, Rimofen

Lyrinel Xl 5mg Prolonged-Release Tablets, Lyrinel

LYRINEL XL 5MG PROLONGED-RELEASE TABLETS

Transcript

THE COLOURS SHOWN ON THIS PROOF ARE FOR GENERAL REPRESENTATION PURPOSES ONLY. THEY ARE NOT ACCURATE AND MUST NOT BE USED AS A COLOUR MATCH FOR THE FINISHED JOB. PLEASE REFER TO THE PANTONE COLOUR GUIDES FOR ACCURATE COLOUR REFERENCES.

This product is known as the above name but will be referred to as Lyrinel XL throughout this leaflet. Other strengths (10mg and 15mg) are also available. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor, pharmacist or nurse. • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4. What is in this leaflet: 1. What Lyrinel XL is and what it is used for 2. What you need to know before you take Lyrinel XL 3. How to take Lyrinel XL 4. Possible side effects 5. How to store Lyrinel XL 6. Contents of the pack and other information

ARIAL REGULAR FONT SIZE 8 ARIAL BOLD FONT SIZE 8 BRIDGED TO CRESTOR 6464/2069 2070

Lyrinel XL works by relaxing your bladder muscles. It also stops bladder contractions and delays the desire to pass urine (water). Your tablets are made in a 'prolonged release' form. The tablets are coated with a ‘special membrane’, which slowly release the medicine. This membrane may pass through your body unchanged. This does not affect the way the medicine works. Lyrinel XL can be used: • To help adults control when and how often they pass urine • In children 5 years or older to treat: - Loss of control in passing urine (urinary incontinence) - Increased need or urgency to pass urine - Night time bedwetting, when other treatments have not worked. If your symptoms do not improve after 7 days talk to your doctor. You must talk to a doctor if at any time your symptoms worsen.

Warnings and precautions Talk to your doctor, pharmacist or nurse before taking Lyrinel XL • if you are elderly and frail (weak or in poor health) as you may be more sensitive to Lyrinel XL • if you have a problem with your gut (stomach or intestine) • if you have hiatal hernia, reflux disease (GERD) or heart burn • if you at taking medicines to treat osteoporosis (drugs known as bisphosphonates) • if you have kidney or liver problems • if you have a problem called ‘bladder outflow obstruction’ which makes it difficult to pass urine • if you have a urinary tract infection • if you have an overactive thyroid • if you have heart problems • if you have high blood pressure • if you have prostate problems • if you have something called ‘dementia’ (memory loss and confusion) and are being treated for it with a certain type of medicine, such as donepezil, rivastigmine, galantamine or tacrine • if you have Parkinson’s disease If you are not sure if any of the above apply to you, talk to your doctor, nurse or pharmacist before taking Lyrinel XL.

Hot weather or fever Care must be taken when using Lyrinel XL in hot weather or in people with a fever. This is because Lyrinel XL reduces the amount a person sweats. This can lead to heat exhaustion and heat stroke.

UK PIL DATED APRIL 2014 REPORTING OF SIDE EFFECTS

28/10/14 DATE OF PROOF:

ARTWORKER: Lyrinel XL 5mg tabs

Other medicines and Lyrinel XL Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes medicines obtained without a prescription, and herbal therapies. This is because Lyrinel XL can affect the way some other medicines work. Also, some other medicines can affect the way Lyrinel XL works.

Children Lyrinel XL is not recommended in children under 5 years of age.

2. What you need to know before you take Lyrinel XL Do not take Lyrinel XL: • If you are allergic to oxybutynin hydrochloride or any of the other ingredients of this medicine (listed in section 6). • If you have raised pressure in your eye (glaucoma) • If you have a muscle weakness problem called ‘myasthenia gravis’ • If you have a feeling of incomplete emptying of the bladder (urinary retention) • If you have a problem with your gut (stomach or intestine) called ‘toxic megacolon’, ‘paralytic ileus’ or ‘intestinal atony’. These are when your gut is blocked, perforated or not working properly • If you have a severe form of condition known as ‘ulcerative colitis’. This is a disease that causes frequent diarrhoea • If you have heart or kidney failure and need to pass urine more often than usual, especially at night • If you have a blood problem called ‘porphyria’. Do not use Lyrinel XL if any of the above apply to you. If you are not sure, talk to your doctor, nurse or pharmacist before taking Lyrinel XL.

PROOF HISTORY: v.1 - waymade - 28/10/14

Leaflet Flat Size = 180 x 429

1. What Lyrinel XL is and what it is used for Lyrinel XL contains a medicine called oxybutynin hydrochloride. This belongs to a group of medicines called ‘anticholinergics’ or ‘antispasmodics’.

In particular, tell your doctor, nurse or pharmacist if you are taking any of the following medicines: • For mental problems such as phenothiazines or butyrophenones and clozapine • For depression called ‘tricyclic antidepressants’ (such as amitriptyline or desipramine) • For Parkinson’s disease such as amantadine or levodopa • For allergy called ‘antihistamines’ (such as chlorphenamine or diphenhydramine) • For heart problems such as quinidine or digitalis • For treating or preventing muscle spasms (antispasmodics such as diazepam) • Used to thin your blood called dipyridamole • Other anticholinergic medicines such as atropine for glaucoma or hyoscine for nausea • For dementia such as donepezil, rivastigmine, galantamine or tacrine • Placed under the tongue to treat angina (sublingual nitrates) • For fungal infections such as ketoconazole, itraconazole and fluconazole • Antibiotics called ‘macrolides’ (such as erythromycin) • Domperidone and metoclopramide – used to stop you feeling sick (nausea) or being sick (vomiting). • Medicines used to help empty the stomach and move foods through the gut (such as domperidone). If you are not sure if any of the above apply to you, talk to your doctor, nurse or pharmacist before taking this medicine. Do not drink alcohol while taking this medicine. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Driving and using machines There have been reports of dizziness and blurred vision with the use of Lyrinel XL. You should therefore be careful when driving, using machinery or performing other tasks that need full attention. Lyrinel XL contains lactose Lyrinel XL tablets contain lactose (0.03 mg), a type of sugar. If you have been told by your doctor that you cannot tolerate or digest some sugars, talk to your doctor before taking this medicine. 3. How to take Lyrinel XL Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. • • • • •

Lyrinel XL should be taken once daily Take your medicine at the same time each day Swallow the tablet whole with a glass of water Do not chew, break or crush the tablet You can take your medicine with food or in between meals.

How much to take Your doctor will decide what dose of medicine is best for you.

LYRINEL® XL 5mg PROLONGED RELEASE TABLETS (oxybutynin hydrochloride) Patient Information Leaflet

WE CANNOT ACCEPT RESPONSIBILITY FOR ANY ERRORS IN THIS PROOF AFTER APPROVAL. THE ARTWORK RECEIVED HAS BEEN SIGNIFICANTLY ADJUSTED, REVISED OR RESET BY US FROM DISK OR HARD COPY. WHILST WE TAKE EXTREME CARE AT ALL TIMES TO ENSURE ACCURACY, THE FINAL RESPONSIBILITY MUST BE TAKEN BY OUR CUSTOMER. IF YOU SIGN THIS PROOF YOU ARE SIGNIFYING FULL APPROVAL OF DESIGN AND TEXT.

THE COLOURS SHOWN ON THIS PROOF ARE FOR GENERAL REPRESENTATION PURPOSES ONLY. THEY ARE NOT ACCURATE AND MUST NOT BE USED AS A COLOUR MATCH FOR THE FINISHED JOB. PLEASE REFER TO THE PANTONE COLOUR GUIDES FOR ACCURATE COLOUR REFERENCES.

Use in adults • The starting dose is normally one 5 mg tablet each day • After at least one week, your doctor may increase your dose to 10 mg each day • Your doctor may increase this to a maximum of 20 mg each day • Your doctor will leave a gap of at least one week between changing the dose. Use in children (over 5 years) • The starting dose is normally one 5 mg tablet each day • Your child’s doctor may increase the dose to a maximum of 15 mg each day. If you take more Lyrinel XL than you should If you think that you have taken too many tablets, tell a doctor or go to the nearest hospital casualty department straight away. Take the medicine pack with you. This is so the doctor knows what you have taken. You may experience symptoms starting as restlessness and excitement, and worsening to circulation changes such as flushing or drop in blood pressure, difficulty breathing, being unable to move your body and losing consciousness. If you forget to take Lyrinel XL • Do not take a double dose to make up for a forgotten dose. • If you forget a dose, do not worry. Just skip that dose and take your next dose at the regular time. If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days: Very common (affects 1 in 10 people or more) • Dry mouth This is more common at doses of more than 10 mg once a day and may lead to tooth decay, gum disease or fungal infection. This may also prevent medicines you put under your tongue dissolving properly (such as angina medicines).

DATE: 28/10/14 06464/2993F CODE:

ARTWORKER: Lyrinel XL 5mg tabs

Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. In the UK, you can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard

Additional side effects in children Constipation is a very common side effect in children. The following are common side effects in children: Loss of appetite, diarrhoea, headache, problems sleeping, rash or itching, flushing.

In Ireland, you can also report side effects directly via: IMB Pharmacovigilance Earlsfort Terrace IRL - Dublin 2 Tel: +353 1 6764971 Fax: +353 1 6762517 Website: www. imb. ie e-mail: imbpharmacovigilance@imb. ie UK PIL DATED APRIL 2014 REPORTING OF SIDE EFFECTS

Other side effects: • Difficulty breathing due to a serious allergic reaction • Psychological problems • Difficulty getting or keeping an erection • Anxiety • Nightmares • Paranoia • Difficulty thinking, remembering information, or solving problems • Dilated pupils • High eye pressure • Lack of sweating • Heat stroke.

CUSTOMER APPROVED: Q. A. APPROVED:

Uncommon (affects less than 1 in 100 people) • Seeing or hearing things that are not there (hallucinations) • Psychological problems, feeling agitated or confused, difficulty remembering • Allergic reaction including hives or swelling of the face, lips, tongue or throat • Difficulty swallowing • Thirst • Loss of appetite, vomiting, frequent bowel movements • High pressure and pain in the eyes (glaucoma), unable to tolerate light • Nasal congestion, impairment of the voice, such as hoarseness • Irregular heartbeat, racing heart • High blood pressure • Chest discomfort • Retaining water • Convulsions • Flushing • Falling • Rash.

Common (affects less than 1 in 10 people) • Abnormal awareness of your heartbeat (palpitations) • Blurred eyesight, dry eyes • Constipation, diarrhoea, nausea, indigestion, stomach pain, change in the way things taste, feeling bloated (flatulence) or heartburn • Feeling tired • Dry skin or itching • Feeling dizzy or sleepy, having a headache, problems sleeping • Pain passing urine, delay when starting to pass urine, feeling of incomplete emptying of your bladder, urinary tract infection • Dry nose, dry or sore throat, cough.

By reporting side effects you can help provide more information on the safety of this medicine. • • • • • • • •

5. How to store Lyrinel XL Keep out of the sight and reach of children Do not store above 25°C. Keep the container tightly closed to protect from moisture. Do not use after the expiry date which is stated on the labelling. The expiry date refers to the last day of that month. Do not remove or swallow the sachet of granules in the bottle. This contains desiccant, which keeps your tablets dry. If your tablets show any signs of discolouration or deterioration consult your pharmacist for advice. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. Contents of the pack and other information What Lyrinel XL contains The active substance is oxybutynin hydrochloride. Each prolonged-release tablet contains 5mg of oxybutynin hydrochloride. Each round, yellow-coloured tablet is printed ‘5 XL’ with black ink and plain on the reverse. Also contains: Butyhydroxytoluene (E321), cellulose acetate, hypromellose, macrogol 3350, magnesium stearate, polyethylene oxide, sodium chloride, black iron oxide (E172), ferric oxide yellow (E172), macrogol 400, polysorbate 80, titanium dioxide (E171), propylene glycol and lactose anhydrous. Available in bottles containing 30 tablets. POM

PL No: 06464/2993

Manufactured by Alza Corporation, Mountain View, California, USA or Alza Corporation, Vacaville, California, USA. And procured from within the EU and repackaged by the Product Licence holder: Waymade plc, Miles Gray Road, Basildon, Essex SS14 3FR Leaflet revision and issue date (Ref.) 28.10.2014 Lyrinel is a registered trademark of Johnson & Johnson.

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Stop taking Lyrinel XL and see a doctor or go to a hospital straight away if: • You have an allergic reaction. The signs may include: a rash, hives (also known as nettle rash or urticaria), difficulty swallowing or breathing, swelling of your lips, face, throat or tongue • You have central nervous system (CNS) effects (changes in thinking or emotions) such as anxiety, nervousness, seeing or hearing things that are not actually there, and trouble thinking clearly or making decisions. Watch for these signs, particularly in the first few months after you start taking your medicine or after an increase in dose. • You have a sudden change in the clearness of your eyesight.

PROOF HISTORY: v.1 - waymade - 28/10/14

Leaflet Flat Size = 180 x 429

4. Possible side effects Like all medicines, this medicine can cause side effects, although not everybody gets them.

WE CANNOT ACCEPT RESPONSIBILITY FOR ANY ERRORS IN THIS PROOF AFTER APPROVAL. THE ARTWORK RECEIVED HAS BEEN SIGNIFICANTLY ADJUSTED, REVISED OR RESET BY US FROM DISK OR HARD COPY. WHILST WE TAKE EXTREME CARE AT ALL TIMES TO ENSURE ACCURACY, THE FINAL RESPONSIBILITY MUST BE TAKEN BY OUR CUSTOMER. IF YOU SIGN THIS PROOF YOU ARE SIGNIFYING FULL APPROVAL OF DESIGN AND TEXT.

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



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Deti a dospievajuci:

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Udrziavacia davka je ? pociatocnej davky. Deti vo veku 5 az 10 rokov: Odporucana davka je ? tablety denne. Deti vo veku 10 az 14 rokov: Odporucana davka je 1 tableta denne.

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Aerosol nasal de budesonida

?Para cuales condiciones o enfermedades se prescribe este medicamento?

El aerosol nasal de budesonida se usa para aliviar los estornudos, la secrecion nasal, la congestion nasal o la comezon en la nariz causada por la fiebre del heno u otras alergias (provocadas por una alergia al polen, al moho, al polvo o a las mascotas). El aerosol nasal de budesonida no se debe usar para tratar sintomas (por ejemplo, estornudos, nariz congestionada, secrecion nasal, comezon en la nariz) provocados por el resfriado comun. El aerosol nasal de budesonida se encuentra en una clase de medicamentos llamados corticoesteroides. Funciona al bloquear la liberacion de ciertas sustancias naturales que causan sintomas de alergia.

?Como se debe usar este medicamento?

La presentacion de la budesonida es en forma de suspension (liquido) (con y sin receta medica) para rociar en la nariz. El aerosol nasal de budesonida usualmente se rocia en cada fosa nasal una vez al dia. Si usted es un adulto, comenzara el tratamiento con una dosis mas alta de aerosol nasal de budesonida y luego reducira la dosis cuando mejoren los sintomas. Si le esta administrando el aerosol nasal de budesonida a un nino, comenzara el tratamiento con una dosis mas baja del medicamento y aumentara la dosis si los sintomas del nino no mejoran. Disminuya la dosis cuando mejoren los sintomas del nino. Siga atentamente las instrucciones que se encuentran en la etiqueta de su receta medica y pida a su medico o farmaceutico que le explique cualquier parte que no comprenda. Use la budesonida exactamente como se indica. No use una cantidad mayor ni menor del medicamento, ni lo use con mas frecuencia de lo que su medico le indique.

Un adulto debe ayudar a los ninos menores de 12 anos a usar el aerosol nasal de budesonida. Los ninos menores de 6 anos de edad no deben usar este medicamento.

El aerosol nasal de budesonida es para usarlo unicamente en la nariz. No se trague el aerosol nasal y tenga cuidado de no rociarlo en los ojos o la boca.

Solo una persona debe usar cada frasco de aerosol nasal de budesonida. No comparta el aerosol nasal de budesonida, ya que esto puede propagar los germenes.

El aerosol nasal de budesonida controla los sintomas de la fiebre del heno o las alergias, pero no cura estas condiciones. Sus sintomas podrian empezar a mejorar 1 a 2 dias despues del primer uso de budesonida, pero podria tomar hasta 2 semanas antes que sienta el beneficio completo de la budesonida. La budesonida funciona mejor cuando se usa de manera regular. Use budesonida en un horario regular a menos que su medico le haya indicado que lo use segun sea necesario. Llame a su medico si los sintomas empeoran o no mejoran despues de usar el aerosol nasal de budesonida todos los dias durante 2 semanas.

El aerosol nasal de budesonida esta disenado para proporcionar cierta cantidad de aplicaciones. Despues de haber usado el numero de aplicaciones marcado, las aplicaciones que quedan en el frasco podrian no contener la cantidad correcta de medicamento. Debe llevar un registro del numero de aplicaciones que ha usado y tirar el frasco a la basura despues de haber usado el numero de aplicaciones marcado, incluso si aun contiene algo de liquido.

Antes de aplicarse el aerosol nasal de budesonida por primera vez, lea las instrucciones escritas que vienen en el empaque. Siga estos pasos:

Agite el frasco suavemente antes de cada uso.

Retire la tapa.

Si va a usar la bomba por primera vez o no la ha usado durante 2 o mas dias seguidos, debe prepararla siguiendo los pasos 4 a 5 a continuacion. Si ha usado la bomba antes y no ha dejado de usarla durante 2 dias seguidos de medicamento, vaya al paso 6.

Sostenga la bomba con el aplicador entre su dedo indice y el dedo medio con la parte de abajo del frasco apoyada sobre su pulgar. Apunte el aplicador lejos de su cara.

Si esta utilizando la bomba por primera vez, presione y libere la bomba ocho veces. Si ha usado la bomba antes, pero no dentro de los ultimos 2 dias, presione y libere la bomba una vez hasta que vea un aerosol fino. Si no ha usado la bomba durante mas de 14 dias, enjuague la punta del aplicador y preparela con dos o mas aplicaciones hasta que vea un aerosol fino.

Limpiese la nariz hasta que las fosas esten despejadas.

Mantenga una fosa nasal cerrada con el dedo.

Incline la cabeza ligeramente hacia adelante y coloque cuidadosamente la punta del aplicador nasal en la otra fosa nasal. Asegurese de mantener el frasco en posicion vertical.

Sostenga la bomba con el aplicador entre su dedo indice y el dedo medio con la parte de abajo apoyada sobre su pulgar.

Comience a inhalar por la nariz.

Mientras respira, use su dedo indice y el medio para presionar el aplicador firmemente hacia abajo y liberar el aerosol.

Incline su cabeza hacia atras y aspire lentamente por la fosa nasal y exhale por la boca.

Si su medico le indico que use aplicaciones adicionales en esa fosa nasal, repita los pasos 6 al 12.

Repita los pasos 6 al 13 en la otra fosa nasal.

No se suene la nariz durante 15 minutos despues de usar el aerosol nasal.

Limpie el aplicador con un pano limpio y tapelo con la cubierta de plastico.

Pida a su farmaceutico o medico una copia de la informacion del fabricante para el paciente.

?Que otro uso se le da a este medicamento?

Este medicamento se puede recetar para otros usos; para obtener mas informacion pregunte a su medico o farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes de usar el aerosol nasal de budesonida,

informe a su medico y farmaceutico si es alergico a la budesonida, a cualquier otro medicamento o a alguno de los ingredientes que contiene el aerosol nasal de budesonida. Revise la etiqueta del empaque para ver la lista de los ingredientes.

Informe a su medico y farmaceutico que medicamentos con y sin receta medica, vitaminas, suplementos nutricionales y productos a base de hierbas esta tomando o tiene planificado tomar. Asegurese de mencionar cualquiera de los siguientes: claritromicina (Biaxin, en Prevpac); inhibidores de la proteasa del VIH como atazanavir (Reyataz, en Evotaz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, en Kaletra, en Technivie), o saquinavir (Invirase); itraconazol (Onmel, Sporanox); ketoconazol (Extina, Nizoral, Xolegel); nefazodona; telitromicina (Ketek). Tambien informe a su medico o farmaceutico si esta utilizando medicamentos esteroides como la dexametasona, metilprednisolona (Medrol) y prednisona (Rayos) para el asma, alergias o una erupcion cutanea. Es posible que su medico deba cambiar las dosis de sus medicamentos o monitorearle atentamente para saber si sufre efectos secundarios.

Informe a su medico si le realizaron una cirugia de nariz recientemente, si se ha golpeado la nariz de alguna manera o si tiene alguna lesion en la nariz. Tambien informe a su medico si tiene o alguna vez ha tenido cataratas (empanamiento del lente del ojo), glaucoma (una enfermedad de los ojos), asma (episodios repentinos de jadeo, falta de aliento y dificultad para respirar), cualquier tipo de infeccion, una infeccion por herpes en el ojo (una infeccion que causa un dolor en el parpado o la superficie del ojo) o enfermedad hepatica. Informe a su medico si tuvo varicela, paperas o tuberculosis (TB; un tipo de infeccion pulmonar) o si ha estado cerca de alguien que tenga una de estas condiciones.

Informe a su medico si esta embarazada, tiene planificado embarazarse o esta amamantando. Llame a su medico si queda embarazada mientras usa budesonida.

?Que tengo que hacer si me olvido de tomar una dosis?

Use la dosis que omitio tan pronto como lo recuerde. Sin embargo, si ya casi es hora de la proxima dosis, omita la dosis que le falto y continue con su programa regular de dosificacion. No duplique la dosis para compensar la dosis omitida.

?Cuales son los efectos secundarios que podria provocar este medicamento?

El aerosol nasal de budesonida puede ocasionar efectos secundarios. Informe a su medico si cualquiera de estos sintomas es intenso o no desaparece:

resequedad, escozor, ardor o irritacion en la nariz

cansancio

debilidad

vomitos

nauseas

dolor de articulaciones o musculos

sangrado de nariz

Algunos efectos secundarios pueden ser graves. Si experimenta algunos de los siguientes sintomas, deje de usar el aerosol nasal de budesonida y llame a su medico de inmediato o busque tratamiento medico de emergencia:

problemas de la vista

fiebre, dolor de garganta, escalofrios, tos y otras senales de infeccion

sonido de silbido de la nariz

urticaria

sarpullido

picazon

inflamacion del rostro, garganta, lengua, labios, ojos, manos, pies, tobillos o parte inferior de las piernas

ronquera

sibilancia

opresion del pecho

dificultad para respirar o tragar

parches blancos en su garganta, en su boca o nariz

Debe saber que este medicamento puede ocasionar que los ninos crezcan despacio. Hable con el medico de su hijo si necesita usar este medicamento durante mas de 2 meses al ano.

El aerosol nasal de budesonida puede causar otros efectos secundarios. Llame a su medico si tiene algun problema inusual mientras usa este medicamento.

Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgacion de efectos adversos 'MedWatch' de la Administracion de Alimentos y Medicamentos (FDA, por su sigla en ingles) en la pagina de Internet (http://www. fda. gov/Safety/MedWatch ) o por telefono al 1-800-332-1088.

?Como debo almacenar o desechar este medicamento?

Mantenga este medicamento en su envase original, cerrado hermeticamente y fuera del alcance de los ninos. Almacenelo a temperatura ambiente y lejos de la luz, del exceso de calor y de la humedad (no en el bano). No lo congele.

Los medicamentos que ya no son necesarios se deben desechar de una manera apropiada para asegurarse de que las mascotas, los ninos y otras personas no puedan consumirlos. Sin embargo, no debe desechar estos medicamentos por el inodoro. En su lugar, la mejor manera de deshacerse de sus medicamentos es a traves de un programa de devolucion de medicamentos. Hable con su farmaceutico o pongase en contacto con su departamento de basura/reciclaje local para conocer acerca de los programas de devolucion de medicamentos de su comunidad. Consulte el sitio web de la Administracion de Medicamentos y Alimentos (FDA), (http://goo. gl/c4Rm4p ) para obtener mas informacion de como desechar de forma segura los medicamentos, si no tiene acceso al programa de devolucion de medicamentos.

?Que otra informacion de importancia deberia saber?

Debe limpiar el aplicador de aerosol nasal periodicamente. Tendra que quitar la tapa de plastico y luego tirar suavemente del aplicador para extraerlo del frasco. Lave la tapa de plastico y el aplicador con agua tibia y enjuaguelo con agua fria, deje secar a temperatura ambiente y luego vuelva a ponerlos en el frasco.

Si la punta del aerosol esta tapada, lavela con agua tibia y luego enjuaguela con agua fria y sequela. No utilice alfileres u otros objetos afilados para eliminar la obstruccion.

Haga a su farmaceutico cualquier pregunta que tenga sobre el aerosol nasal de budesonida.

Es importante que Ud. mantenga una lista escrita de todas las medicinas que Ud. esta tomando, incluyendo las que recibio con receta medica y las que Ud. compro sin receta, incluyendo vitaminas y suplementos de dieta. Ud. debe tener la lista cada vez que visita su medico o cuando es admitido a un hospital. Tambien es una informacion importante en casos de emergencia.

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BACTRIM is contraindicated in pediatric patients less than 2 months of age.

Urinary Tract Infections and Shigellosis in Adults and Pediatric Patients, and Acute Otitis Media in Children:

Adults: The usual adult dosage in the treatment of urinary tract infections is 1 BACTRIM DS (double strength) tablet or 2 BACTRIM tablets every 12 hours for 10 to 14 days. An identical daily dosage is used for 5 days in the treatment of shigellosis.

Children: The recommended dose for children with urinary tract infections or acute otitis media is 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim per 24 hours, given in two divided doses every 12 hours for 10 days. An identical daily dosage is used for 5 days in the treatment of shigellosis. The following table is a guideline for the attainment of this dosage:

Children 2 months of age or older:

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Theo Galavan - Villains Wiki, Theo

Theo Galavan

Theo Galavan after being ultimately defeated and facing death

Theodore "Theo" Dumas (later Galavan) is the main antagonist in the Rise of the Villains arc and a supporting antagonist in the Wrath of the Villains arc of the second season in the TV series Gotham . who made his debut at the beginning of the season alongside his sister Tabitha. After arriving at Gotham City, he quickly manages to become the city's mayor through manipulation, deception and blackmail.

While seen as a savior in the eyes of the public, he in truth plans to destroy the Wayne Family and their legacy, as his ancestors were driven out of the city by them two centuries ago. His actions eventually bring Jim Gordon and Penguin to combine forces which leads to Galavan's death by the hands of Gordon. Galavan's body is delivered to Indian Hill, a research facility led by Professor Strange.

Theo's body is experimented on and eventually, Strange manages to successfully reanimate him. Despite showing enhanced physical abilities, Theo's mind seems to have suffered a great deal during the reanimation. After a conversation with Edward Nygma, Hugo Strange finds a new way to put Theo to use by giving him a new persona. Strange manages to convince the fragmented, confused and extremely dangerous Theo that he is his father and that his name is Azrael . a knight of the Sacred Order of the Saint of Dumas to be used as an "instrument to enforce God's will." During this mission, parts of Theo resurface in Azrael and he sets out to fulfil his original mission - killing Bruce Wayne. During a showdown at Wayne Manor, he is ultimately killed by the combined efforts of Bruce, Alfred, Gordon, Penguin and Butch.

He is played by James Frain who also played Franklin Mott, Eric Renard and Reyes.

Contents

Biography

Past

Together with his sister Tabitha, Theo grew up at an estate near the shore. The two grew up happy until Theo was indoctrinated into the Order of Saint Dumas.

Bettering his appearance

Theo begins his conquest of Gotham by intoxicating Zaardon. one of his underlings, with a knock out gas. After Zaardon is imprisoned in Arkham Asylum, Galavan uses him to break six inmates out of the Asylum, including Jerome Valeska. Barbara Kean and Richard Sionis. He offers each of them to partake in his plans. When Sionis denies him, he has him killed by his sister Tabitha. During the breakout in Arkham, Galavan is present at the retirement ceremony of Commissioner Gillian Loeb. where he holds a speach for the mayor who is said to be otherwise occupied. However, it is revealed that Galavan kidnapped the mayor, forcing him to call his secretary and tell her that he run off with a woman.

He then meets with his Maniax. telling them that they now have the attention of Gotham and will be on TV soon. When it is clear that Jerome and Greenwood don't get along, Theo states that this problem must be solved immediately. He draws a gun and removes all but one bullet, telling them to play a game of Russian Roulette. Greenwood shoots at himself but nothing happens. When Jerome does that not once but thrice, Galavan makes him the leader of the Maniax, sensing that Jerome's charisma and madness makes him perfect for the leading role of the Maniax.

The day after the shooting at the police precinct, Theo walks in on his sister and Barbara making out. He doesn't mind, but tells Tabitha to go entertain Jerome while he has to talk to Barbara. Tabitha leaves, not before kissing Barbara. After Tabitha is gone, Theo tells Barbara that he is glad that he and Tabitha get along so well because Tabitha needs a friend. He then congratulates her for her role in the attack on the GCPD. He also tells Barbara that his forefathers built Gotham and that they were betrayed. He plans to retake Gotham and tells her that the Maniax were only part one of his undertaking. He offers Barbara to help her destroy Jim Gordon after he has outlived his usefulness in the plan.

Theo kills Jerome

He visits the benefit gala at the Children's hospital together with Tabitha. When Barbara asks Theo if he wants to share his plans for the evening with her, he replies that he will give Gotham a hero. At the gala, he talks to Deputy Mayor Kane who wants to wrinkle out some secrets about him out of him. When Kane tells Tabitha jokingly that the "appearance of a handsome billionaire out of nothing" raises questions, Tabitha replies that her brother is a "monster in a sack" which leads to an uncomfortable silence. Tabitha then asks the Deputy Mayor if there are any news on Mayor James. After taking their leave from Kane, Tabitha tells her brother that everything is ready and tells him that she will see him at home. When Jerome's show starts Theo's men lock the doors, trapping the guests inside the room with his assets Jerome and Barbara.

When Jerome, disguised as the magician, kills the Deputy Mayor and takes the guests hostage, Theo stands up, calling Jerome a small vicious man with a pathetic need for attention. Jerome replies that he will shoot him in the head if he does not step down. As all of this is broadcasted on live television, it seems to the public that Theo is risking his life for the guests inside. On the stage, Theo seemingly tries to reason with Jerome only to be knocked out by Barbara. With Alfred's help, Gordon is able to kill all of Jerome's henchman and both of them corner Jerome on the stage. Jerome has taken Bruce as a hostage so the men cannot risk shooting at him. The situation is deescalated when Theo gets up behind Jerome and stabs him in the neck. He quietly apologizes to Jerome, acknowledging his talent but tells him that Theo himself will now enter the stage - as the hero. After the mess is cleared, Alfred introduces himself to Theo and thanks him for saving Bruce's life to which Theo replies that the only did what every citizen should have done. Theo then shakes Gordon's hand, telling him that he can always ask if he needs anything, given that they are in this together.

The whole situation gives Theo a huge image boost. Upon Barbaras return to Theo's home he watches the news reporting of Jerome's death.

Using Penguin

Theo sends out Tabitha to invite Penguin to discuss business. During this meeting Tabitha calls Penguin the "King of Garbage". Theo then intervenes and tells Penguin that while his sister is blunt, she is also honest. He then shows Penguin his plans for the city, giant futuristic skyscrapers. When Penguin states that thousands of homes have to be destroyed to allow the building of the skyscrapers Tabitha replies: "Yeah, so?", which deeply annoys Penguin.

Theo watches the news about his heroic deed

Theo tells Penguin that as the city's hero he can not destroy so many homes but remarks that Penguin has the flair for such a task. He then calls Penguin his "destroyer". Penguin denies Galavan's offer, calling himself a "builder" rather than a destroyer and remarks that Galavan would need the support of hundreds of city officials. Theo then reveals that as mayor he would have the power to do so, stating that he will be candidate soon by "popular demand". As some of the other candidates have a chance to defeat him, he has Tabitha give Penguin a list of people he needs to see dead as well as a failed attempt on Theo himself. When Penguin tells him to search the phone book under " A" for "Assassin" and prepares to leave, Tabitha turns on the TV. To his horror, Penguin sees that Galavan has kidnapped his mother and is forced to agree. For his bravery at the hostage situation at the gala Theo is publically awarded the Medal of Valor and Bravery. During the ceremony, one of Penguin's thugs drives by and shoots at Theo, missing him with every shot. Using the opportunity, Theo states that he will not bow down to those who try to destroy Gotham. He announces his candidature for mayor which is greeted with applause.

At a dinner between Bruce and Theo, Bruce asks Theo for saving his life. Theo acts humble, saying that he did not know what came over him. Theo then reveals that he wanted to talk with Bruce, saying that he finds it shocking that the police did not find any clues on the murderer of Bruce's parents. He then introduces Bruce to his ward Silver St. Cloud. the daughter of Theo's deceased step-brother to whom Bruce takes a liking.

Feud with Penguin

Later, Theo reveals to Tabitha that while the GCPD hunts down the Penguin he will steal the job of the mayor right from under their noses. As well as Mayor James, Theo has his sister kidnap Sid Bunderslaw. He orders Tabitha to gouge out one of Bunderslaw's eyes. After Penguin killed Janice Caulfield and failed to kill Hobbs, he returns to Galavan and asks for his mother's release, stating that he would still do Galavans bidding. Theo denies and tells him to leave. Penguin is now determined to take down Galavan and get revenge on him. His right hand Butch Gilzean advises him to kidnap Tabitha and trade her for Cobblepots mother but Penguin doubts that Theo loves Tabitha as much as Penguin loves his mother. Theo later sends Tabitha to Cobblepot to give him a list of multiple buildings owned by Wayne Enterprises which Theo wants burned down. Theo also wants Cobblepot to steal an old knife out of a safe in one of the building. He arranges for Cobblepot to receive Bunderslaws eye which is needed to open the safe.

Penguin is able to get the knife and burn down the buildings. However, as he plans to find out what drives Theo in order to destroy him Penguin meets Edwige, an old associate of Butch to find out the history of the knife. Edwige tells him that the knife is the Wayne Family Crest which was used 200 years ago by an ancestor of Bruce Wayne to cut off the hand of Caleb Dumas after the latter was accused of raping Celestine Wayne. The angered Waynes forced Dumas and his entire family into exile where the Dumas changed their name to Galavan. Penguin learns that Theo is a descendant of the Dumas and wants revenge on the Waynes. Penguin is glad because this means Theo is driven by emotion and thereby vulnerable. He then plans for Butch to seemingly change sides, claiming that Cobblepot is too mad to serve, and get into Galavan's business, but in reality plans for Butch to search for Oswald's mother. To not give Theo the opportunity to doubt Butch's story, Penguin cuts off one of his hands.

Theo indeed accepts Butch in his service but later reveals that he knows that Butch is loyal to Penguin. When he asks Butch how Penguin has convinced him to cut off his hand, Butch reveals that he was brainwashed and has to obey Penguin, whatever he is tasked with. Theo then calls Tabitha and orders her to free Butch's mind. He then leaves the room, leaving Tabitha and Butch alone. Later he has dinner with Silver, Tabitha and Bruce. After the dinner he talks to Bruce, telling him that Sid Bunderslaw is missing and that he is watching Wayne Enterprises closely because although Bruce's father was a good man the company was still corrupted.

Making enemies

After Butch, now free from Penguin's influence, leads Penguin to the warehouse his mother is imprisoned at Theo and Tabitha arrive, with Theo holding the key to Gertrude's cell. Penguin, who has arrived with Butch and two henchmen, orders Butch to shoot both Theo and Tabitha in the head. However, Butch shoots Penguins men instead, thereby revealing that he is free from Penguin's influence. Outnumbered and alone, Penguin begs Theo to spare his mother. Theo indeed seems to give in when he hands Tabitha the key to the cell, but this changes immediately when Tabitha frees Gertrud and stabs her in the back moments later. While Oswald comforts his dying mother, Theo orders Butch to kill Penguin but Penguin, who states that Theo does not have the guts to do it himself and that his family was banished because they come from a line of cowards.

Gordon faces Theo

Theo then takes the gun and sadistically asks if Penguin has any last words to which Penguin answers: "I'm gonna kill you" and slices into his neck with the knife Tabitha used to kill his mother. Penguin jumps out of a window and escapes.

The next day, Theo, who has been voted to become mayor, visits the police department and claims that Penguin arrived at his house and proposed an alliance, only to attack and stab Theo when he declined. Commissioner Nathaniel Barnes states that he will do everything possible to bring Penguin behind bars. Theo states that once he is mayor he will give the GCPD additional powers to make it easier to capture Penguin. Gordon is concerned, but Theo reminds him that Gordon came to him for help. Later, Gordon confides into Bullock that he doesn't believe Galavan's story and starts linking the events of the last months to Galavan.

When Tabitha tells Theo that Penguin will now have been gone underground, impossible to find, Theo replies that his hate will could his better judgment and that he will deliver himself.

On the victory celebration party for Theo, Penguins men crash the party. Gordon plans to bring Galavan out into safety, however they are ambushed by Penguin who plans to kill Theo. This leads to a standoff between Gordon and Penguin. While Theo orders Gordon to shoot Penguin, Penguin tells Gordon that Theo killed his mother. While Gordon tries to talk Penguin out of shooting, Tabitha uses a sniper rifle to shoot Penguin in the shoulder. Penguin manages to escape. Later, Gordon confronts Theo, stating that he plans to take him out. Theo replies that this is a dangerous thing to say to someone who now controls the city.

Chase of Bruce Wayne

Theo plans on getting hold of Wayne Enterprises and makes a proposition to Bruce that if he signs over his share Theo will give him a file containing the identity of his parent's killer. Bruce is tempted, however he later turns down Theo's deal. During this James Gordon arrives to arrest Theo after they managed to find Aubrey James. Before being arrested Theo quickly tosses the file into a nearby fireplace, much to Bruce's devastation.

Days later, Edward Nygma reveals to Penguin that Galavan was sent to Blackgate Prison.

After Eduardo Flamingo failed to kill James Gordon, Tabitha visits Theo at Blackgate where he can't believe that she sent hitmen after James Gordon. He tells her that Bruce Wayne will die soon and that the prophecy will be fulfilled imminently and that he will cut Tabitha's throat if she threatens that once again.

Gordon as Theo's prisoner

When Aubrey James is supposed to give the testimony that will lead to Theo's incarceration, James instead tells the judge that Penguin kidnapped him and forced him to lie. Due to lack of evidence, Theo is cleared from all charges. He then addresses the crowd, telling them that he is not angry with Gordon or the GCPD as they only did their job. He tells Gordon that he hopes that the two of them can continue saving the city, to which Gordon replies by striking him in the face. Gordon tries to continue beating Galavan but is subdued by two of Galavan's henchmen who are disguised as policemen. They bring Gordon outside and there, out of sight, taser him.

When he regains consciousness, Gordon is strapped upon a table in a warehouse. Galavan walks towards him, remarking how many things can change in just one day, with Theo being a free man and Gordon being the prisoner. He reveals himself as Theo Dumas and tells Gordon that the Order od St. Dumas helped him obtaining his power. In the conversation, Gordon realizes that Theo plans to murder Bruce Wayne. He tells his men to shoot Gordon but changes his mind, ordering them to cut Gordon lose. When Gordon is free, Theo tells him to give it his best shot to save Gotham. Gordon attacks Theo but is easily defeated by him. Theo leaves the almost unconscious Gordon on the ground and tells his men to kill him, but slowly. He then leaves the warehouse and heads for Wayne Manor, where he faces Bruce and draws his knife, revealing to Bruce that he plans to kill him.

Death to the Son of Gotham

Galavan at the "Death to the Son of Gotham" ceremony

After confronting Bruce Wayne and imprisoning him in a cell in the cellars of his penthouse, he is approached by Silver who tells him that she thinks that she has a cold and wonders if she could miss the ceremony. Theo quickly sees through that and deduces that Silver still has feelings for Bruce, which Silver denies. Tabitha tries to come to Silver's aid but is talked down by Theo. To prove her worth to the family, Theo puts Silver to a test, ordering her to make Bruce Wayne fall in love with her again. Not planning to give Theo a reason to kill Silver, Bruce later kisses Silver while Theo watches, much to the latter's delight. However, while Bruce is to be executed Silver stops the ceremony and a shocked Theo realizes that she has betrayed him. A combined force of Gordon, Penguin. Alfred and Selina Kyle then interrupt the ceremony and attack the members of the order. During the fight, Theo manages to retreat with Tabitha and Silver while Bruce Wayne is saved and the members of the order, including their leader Creel, are killed. After ensuring that Bruce is well, Gordon continues his hunt for Galavan.

Death and resurrection

Kill me, please. Please.

Strange made Theo believed that he was Azreal reborn

Although Theo has returned from the dead, his psyche has suffered enormously. Strange and Peabody watch Theo in his cell, displaying paranoia as well as rage. Depite Theo's meltdown, Strange is fascinated with his new subject. Also, Strange recognizes that everything Theo babbles comes from the book 'The Will and Order of Saint Dumas'. Strange eventually realises how he can solve his problem with Galavan. Much to the horror of Peabody, Strange enters Theo's cell and is immediately attacked by Galavan. Strange tells Galavan that he is his father and that demons took him to the lands of death. Theo is not convinced, remembering things of his past including that he has a sister and the face-off with Gordon at the tower. Strange tells him that these memories are false. By quoting the book of Dumas, Strange eventually convinces Theo who recognizes Strange as 'Lord Dumas', offering him his service.

Azrael attacks Gordon

Strange then brainwashes Theo into completely adapting the identity of Azrael. He then decides to test whether the procedure has been a success. He has Aaron Helzinger brought into Theo's cell and provides Theo with a case containing the 'Sword of Sin'. He tells Theo that Helzinger is a demon and that the case contains everything Theo needs to destroy him. Despite his expectations, Theo simply uses the case to knock out Helzinger. Satisfied enough with the outcome, Strange sends Azrael into Gotham to kill Gordon.

Azrael later tracks down Gordon who is talking to Barnes. He reveals that he has come to kill Gordon. Both men draw their weapons and order Azrael to drop his sword but Azrael instead flees into the shadows. Using the shadows as an advantage, eventually striking and knocking Barnes into a pile of pallets. He briefly attacks Gordon who evades every blow. When Bullock and the rest of the police forces arrive they open fire at Azrael who is forced to flee. Despite the heavy gunfire, Azrael uses his agility skills to dodge the bullets - those who hit him are caught by his heavy armor - and climing the nearby building, eventually escaping into the night. On his way out, Azrael walks past a poster for Theo Galavan's mayoral candidature which triggers flashbacks from the past - including that Gordon killed him.

Azrael's identity is revealed

According to his mission, Azrael attacks the GCPD after creating an energy blackout. Blasting through the precinct's window he immediately hides in the shadow, claiming that he has come to vanquish the evil that is Jim Gordon. Barnes shouts that Azrael can die trying. Azrael offers then offers Barnes - whom he identifies as the one to 'lead these men' - to parlay. He offers that they will live should they give him Gordon but Barnes tells him to go to hell. He then grabs a police officer, vanishing in the darkness before killing the man. He then kills off the policemen one by one, using the dark precinct to disguise his moves. Eventually, Barnes fires an entire magazine into Azrael which leaves him motionless on the ground. However, Azrael rises again. Realizing that mere bullets will not stop Azrael, Barnes lures him to the roof while Gordon searches for a bigger weapon. Azrael tracks Barnes down to the roof where Barnes uses a crowbar to fend off Azrael. The crowbar eventually shatters the sword, leaving Azrael utterly shocked. Barnes uses the opportunity to knock down Azrael with the crowbar. A crowbar blast knocks the mask off of Azrael's face, revealing to Barnes that Azrael is Galavan. Azrael uses the opportunity to fatally stab Barnes with the remainders of the blade. Gordon arrives and uses a shotgun to blast Azrael off the roof. Azrael lands on top of a van and right in front of a TV crew reporting of the shooting at the precinct. As a result, all of Gotham is aware that Galavan is still alive.

Memories Restored and Final Death

Bruce Wayne. We were sent to kill him. He dishonored our family name! Death to the Son of Gotham! Thank you for reminding me, traitor.

Theo stabs his sister.

Instead of returning to Strange, Azrael instead enters a church in search for the true Sword of Sin. When he is discovered by a priest, the man attempts to throw him out, claiming the church is no homeless shelter. However, once Azrael looks up to reveal his mask, the priest backs off frightened. Azrael demands a weapon to fulfil his destiny from the priest and after the man told him that there were no weapons at the church, breaks the priests neck before leaving.

Azrael meets Tabitha.

Azrael eventually finds out that the sword is located at the Dumas Crypt. He watches as Gordon and Bullock, led by his sister Tabitha open the tomb and take the sword. He then attacks Bullock, knocking him out while dodging Gordon's gunfire. He advances onto Gordon and throws him through a door but before he can follow the way is blocked by Tabitha. Azrael, not recognizing her, tells Tabitha to step aside but Tabitha tries to remind him of his true identity. She succeeds, but Theo also remembers that the two of them tried to kill Bruce Wayne and that Tabitha betrayed him. For her betrayal, Theo impales her on the Sword before escaping from the church. He sets off to continue his true task - killing Bruce Wayne. Before leaving the area he slashes the tires of Gordon's car.

He then heads to Wayne Manor where Alfred and Bruce are already preparing for his attack. He infiltrates the mansion, eventually facing Alfred. He demands that Alfred leads him to Bruce but Alfred refuses. A sword fight between Alfred and Theo ensues which is disturbed when Bruce enters the room. Theo attempts to kill Bruce, giving Alfred a brief advantage. However, Theo regains the upper hand and throws Alfred out of the window. Bruce flees from the room and hides in the garage of Wayne Manor where Theo eventually tracks him down. Theo claims that the Waynes were a blight onto Gotham. By further insulting the honor of the Wayne Family, Theo tries to lure Bruce out of his cover. However, Bruce uses the time this gained him to set a trap for Galavan. Believing to see Bruce hiding behind a car, Theo heads in that direction but finds that Bruce only left his shoes there for Theo to find. Bruce then drives another car into Theo and breaks through the garage doors. Believing to be rid of Theo, Bruce stops the car outside Wayne Manor and steps out only to be attacked by Theo once again. Theo strangles Bruce with Tabitha's whip but then removes the rope in order to execute him properly.

Theo faces death.

However, before he can strike he is shot multiple times by Gordon who arrives just in time. Believing Theo to be dead, Gordon and Alfred rush to Bruce's side but Theo gets up once more. Furthermore, Gordon had already emptied his entire magazine into Theo. When realising that, Theo smiles but is disturbed when he hears Penguin's voice behind him. The baffled Galavan turns to see Cobblepot standing near the gates of Wayne Manor, casually telling Jim that bullets won't kill Theo. He then moves aside to make room for Butch who carries a rocket launcher. Butch fires the launcher directly at Theo who, realizing that he can't escape the blast, merely closes his eyes as he is hit by the rocket.

Powers and Abilities

Resurrection Enhancements . He was artificially resurrected by Hugo Strange, thereby coming back to life, but with a fractured mind & a delusional personality.

Enhanced Strength . After his resurrection, Hugo Strange notes that Theo was as strong as an ox. He was able to toss strong orderlies around with just a push of his hand.

Enhanced Speed . After his resurrection, Hugo notes that Theo was as fast as a snake. He is able to move & react faster than shotgun rounds.

Enhanced Healing . After his resurrection, his bullet wound disappeared without even a scar. Even after receiving major physical traumas, he is still able to continue fighting.

Hand-to-Hand Combatant . Theo was shown to have advanced martial arts skills as seen when he manages to best Jim Gordon in hand-to-hand combat, with little effort. This combined with his enhanced physical abilities, make him a very powerful fighting machine.

Guerrilla Warfare . He is able to use predatory techniques and disappear into the shadows, something which mirror's Batman's predatory techniques in the DC Comics.

Appearances

Appearances for Theo Galavan

Gotham

Season 2

2x01: "Rise of the Villains: Damned If You Do. "

2x02: "Rise of the Villains: Knock, Knock"

2x03: "Rise of the Villains: The Last Laugh"

2x04: "Rise of the Villains: Strike Force"

2x05: "Rise of the Villains: Scarification"

2x06: "Rise of the Villains: By Fire"

2x07: "Rise of the Villains: Mommy's Little Monster"

2x08: "Rise of the Villains: Tonight’s the Night"

2x09: "Rise of the Villains: A Bitter Pill to Swallow"

2x10: "Rise of the Villains: The Son of Gotham"

2x11: "Rise of the Villains: Worse Than A Crime"

2x12: "Wrath of the Villains: Mr. Freeze" (flashback)

2x13: "Wrath of the Villains: A Dead Man Feels No Cold" (corpse)

2x18: "Wrath of the Villains: Pinewood"

2x19: "Wrath of the Villains: Azrael"

2x20: "Wrath of the Villains: Unleashed"

Gotham Stories

"Chapter 3: Can Gordon and Bullock Help Oswald?"

Gallery

As Theo Galavan



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NAME OF THE MEDICINAL PRODUCT Fludex 1.5 mg SR Tablets

QUALITATIVE AND QUANTITATIVE COMPOSITION One prolonged-release film-coated tablet contains 1.5 mg indapamide. Excipient with known effect: 124.5 mg lactose monohydrate For the full list of excipients, see section 6.1.

Prolonged-release tablet. White, round, film-coated tablet.

CLINICAL PARTICULARS Therapeutic indications Fludex 1.5 mg SR is indicated in essential hypertension in adults.

Posology and method of administration Posology One tablet per 24 hours, preferably in the morning, to be swallowed whole with water and not chewed. At higher doses the antihypertensive action of indapamide is not enhanced but the saluretic effect is increased. Special populations Renal impairment (see sections 4.3 and 4.4): In severe renal failure (creatinine clearance below 30 ml/min), treatment is contraindicated. Thiazide and related diuretics are fully effective only when renal function is normal or only minimally impaired. Hepatic impairment (see sections 4.3 and 4.4): In severe hepatic impairment, treatment is contraindicated. Elderly (see section 4.4): In the elderly, the plasma creatinine must be adjusted in relation to age, weight and gender. Elderly patients can be treated with Fludex 1.5mg SR Tablets when renal function is normal or only minimally impaired.

Paediatric population: The safety and efficacy of Indapamide Arrow 1.5 mg in children and adolescents have not been established. No data are available. Method of administration Oral use.

Contraindications - Hypersensitivity to the active substance, to other sulfonamides or to any of the excipients listed in section 6.1. - Severe renal failure. - Hepatic encephalopathy or severe impairment of liver function. - Hypokalaemia.

Special warnings and precautions for use Special warnings When liver function is impaired, thiazide-related diuretics may cause hepatic encephalopathy, particularly in case of electrolyte imbalance. Administration of the diuretic must be stopped immediately if this occurs. Photosensitivity: Cases of photosensitivity reactions have been reported with thiazides and thiaziderelated diuretics (see section 4.8). If photosensitivity reaction occurs during treatment, it is recommended to stop the treatment. If a re-administration of the diuretic is deemed necessary, it is recommended to protect exposed areas to the sun or to artificial UVA. Excipients: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Special precautions for use - Water and electrolyte balance: • Plasma sodium: This must be measured before starting treatment, then at regular intervals subsequently. The fall in plasma sodium may be asymptomatic initially and regular monitoring is therefore essential, and should be even more frequent in the elderly and cirrhotic patients (see sections 4.8 and 4.9). Any diuretic treatment may cause hyponatraemia, sometimes with very serious consequences. Hyponatraemia with hypovolaemia may be responsible of dehydration and orthostatic hypotension. Concomitant loss of chloride ions may lead to secondary compensatory metabolic alkalosis: the incidence and degree of this effect are slight. • Plasma potassium: Potassium depletion with hypokalaemia is the major risk of thiazide and related diuretics. The risk of onset of hypokalaemia ( Yes No

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