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Macrobid Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Macrolid

Macrobid

Uses

This medication is an antibiotic used to treat bladder infections (acute cystitis). It works by stopping the growth of bacteria.

This antibiotic treats only bacterial infections. It will not work for viral infections (e. g. common cold. flu ). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

This medication should not be used in infants younger than 1 month old (see also Precautions section). This drug should not be used to treat infections outside the bladder (e. g. kidney infections such as pyelonephritis or perinephric abscesses).

How to use Macrobid

Take this medication by mouth with food, usually twice daily in the morning and evening or as directed by your doctor. Swallow the medication whole for best results.

Do not use magnesium trisilicate-containing antacids while taking this medication. These antacids can bind with nitrofurantoin. preventing its full absorption into your system.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.

Inform your doctor if your condition persists or worsens.

Side Effects

Nausea. headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may cause your urine to turn dark yellow or brown in color. This is usually a harmless, temporary effect and will disappear when the medication is stopped. However, dark brown urine can also be a sign of rare side effects (liver problems or anemia ). Therefore, seek immediate medical attention if you notice dark urine along with any of the following symptoms: persistent nausea/vomiting. stomach /abdominal pain. yellowing eyes /skin. tiredness, fast/pounding heartbeat.

Tell your doctor right away if any of these rare but very serious side effects occur: eye pain. vision changes, mental/mood changes, persistent/severe headaches. new signs of infection (e. g. fever, persistent sore throat ), easy bruising/bleeding.

Seek immediate medical attention if you develop the following rare but very serious side effects: numbness/tingling of the hands/feet, unusual muscle weakness .

This medication may rarely cause very serious (possibly fatal) lung problems. Lung problems may occur within the first month of treatment or after long-term use of nitrofurantoin (generally for 6 months or longer). Get medical help right away if you develop symptoms of lung problems, including: persistent cough. chest pain. shortness of breath/trouble breathing. joint/muscle pain. bluish/purplish skin.

This medication may rarely cause a severe intestinal condition (Clostridium difficile - associated diarrhea ) due to a resistant bacteria. This condition may occur during treatment or even weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood /mucus in your stool.

Use of nitrofurantoin for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth. a change in vaginal discharge. or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking nitrofurantoin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: kidney disease (e. g. little or no urine output), a certain genetic condition (G-6-PD deficiency), a history of liver problems due to nitrofurantoin use in the past.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, lung disease, numbness/tingling of the arms/legs, vitamin B deficiency, mineral imbalance, blood disorders (e. g. anemia), diabetes, persistent weakness due to long-term disease, certain eye disorders (e. g. optic neuritis ).

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, older adults may be at a greater risk for side effects while using this drug, especially nerve, liver or lung problems (see Side Effects section).

During pregnancy, this medication should be used only when clearly needed. It must not be used if you are near the end of your pregnancy (38-42 weeks), or at the time of labor and delivery. Doing so may cause a certain blood disorder (hemolytic anemia) in your baby. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on nursing infants younger than 1 month old or those with a certain genetic condition (G-6-PD deficiency). Consult your doctor before breast-feeding.

Interactions

(See also How to Use section).

Your healthcare professionals (e. g. doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially: certain drugs to treat gout (uricosuric drugs such as sulfinpyrazone).

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

This medication may interfere with certain laboratory tests (certain urine glucose tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in those cases.

Laboratory and/or medical tests (e. g. kidney/liver function, blood counts/CBC, bacterial culture) should be performed periodically to monitor your progress or check for side effects. Lung function tests should be performed if you are prescribed nitrofurantoin products for extended treatment (several months or more). Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Nevirapine Advanced Patient Information, Ritvir

nevirapine (Oral route)

Oral route(Tablet;Tablet, Extended Release;Suspension)

Severe, life-threatening, in some cases fatal, hepatotoxicity and skin reactions (eg, Stevens-Johnson syndrome; toxic epidermal necrolysis; and hypersensitivity reactions characterized by rash, constitutional findings, and organ dysfunction) have been reported. Women, including pregnant women, and/or patients with higher CD4+ cell counts are at higher risk of hepatotoxicity. Permanently discontinue nevirapine following severe hepatic, skin, or hypersensitivity reactions. Monitor patients intensively during the first 18 weeks of therapy with nevirapine to detect potentially life-threatening hepatotoxicity or skin reactions. Strictly follow the 14-day lead-in period with immediate-release nevirapine 200 mg daily dosing .

Commonly used brand name(s)

Available Dosage Forms:

Therapeutic Class: Antiretroviral Agent

Pharmacologic Class: Non-Nucleoside Reverse Transcriptase Inhibitor

Uses For nevirapine

Nevirapine is used in combination with other medicines for the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS).

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It works by lowering the amount of HIV in the blood.

Nevirapine will not cure HIV infection or AIDS; however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of problems that usually result from AIDS or HIV disease. Nevirapine will not keep you from spreading HIV to other people. People who receive nevirapine may continue to have some of the problems usually related to AIDS or HIV disease.

nevirapine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, nevirapine is used in certain patients with the following medical condition:

Mother-to-child transmission of HIV during labor and at birth (prevention).

Before Using nevirapine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nevirapine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to nevirapine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of nevirapine suspension or tablets in children. However, safety and efficacy have not been established in infants younger than 15 days of age.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of nevirapine extended-release tablets in children 6 to 17 years of age. However, use is not recommended in children younger than 6 years of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nevirapine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require caution and an adjustment in the dose for patients receiving nevirapine.

Pregnancy

Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking nevirapine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using nevirapine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using nevirapine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amprenavir

Apixaban

Artemether

Avanafil

Boceprevir

Bosutinib

Clozapine

Cobicistat

Cyclophosphamide

Daclatasvir

Darunavir

Delavirdine

Dexamethasone

Dolutegravir

Donepezil

Doxorubicin

Doxorubicin Hydrochloride Liposome

Efavirenz

Eliglustat

Elvitegravir

Enzalutamide

Etravirine

Fluconazole

Fosamprenavir

Hydrocodone

Ifosfamide

Itraconazole

Ivabradine

Ketoconazole

Nifedipine

Olaparib

Palbociclib

Piperaquine

Quinine

Rifampin

Rifapentine

Rilpivirine

Simeprevir

St John's Wort

Telaprevir

Tolvaptan

Voriconazole

Using nevirapine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amiodarone

Caspofungin

Cisapride

Clarithromycin

Clonazepam

Cyclosporine

Dalfopristin

Diltiazem

Disopyramide

Ergotamine

Ethosuximide

Fentanyl

Indinavir

Lopinavir

Methadone

Nelfinavir

Ospemifene

Quinupristin

Rifabutin

Saquinavir

Sirolimus

Tacrolimus

Verapamil

Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of nevirapine. Make sure you tell your doctor if you have any other medical problems, especially:

Hepatitis B or

Hepatitis C—Use with caution. May cause side effects to become worse.

Liver disease, moderate or severe—Should not be used in patients with this conditions.

Proper Use of nevirapine

Take nevirapine exactly as directed by your doctor . Do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not change the dose or stop using nevirapine without checking first with your doctor. When your supply of nevirapine is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of nevirapine.

nevirapine comes with a Medication Guide. Read and follow these instructions carefully before starting nevirapine treatment and each time you refill your prescription. Ask your doctor if you have any questions.

Nevirapine may be taken with or without food, and with water, milk, or soda.

If you or your child are taking the oral liquid . shake it gently before use. Use an oral dosing syringe or dosing cup to measure the right dose. After drinking the medicine, rinse the dosing cup with water and drink the water to make sure you get all of the medicine. If your dose is less than 5 mL (one teaspoonful), use the dosing syringe.

Swallow the extended-release tablet whole. Do not crush, break, or chew it.

Keep taking nevirapine for the full time of treatment . even if you or your child begin to feel better.

It is important to take nevirapine as part of a combination treatment. Take all other medicines your doctor has prescribed at the right time of the day. This will make your medicines work better.

nevirapine works best when there is a constant amount in the blood. To help keep blood levels constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times during the day . For example, if you or your child are taking one dose per day, try to take it at the same time each day. If you are taking two doses per day, the doses should be spaced about 12 hours apart. If you need help planning the best times to take your medicine, check with your doctor.

Do not take more than one dosage form of nevirapine at the same time. Talk to your doctor if you have any questions.

If you stop taking nevirapine for more than 7 days, ask your doctor how much to use before you start taking it again.

Dosing

The dose of nevirapine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of nevirapine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of HIV infection:

For oral dosage form (extended-release tablets):

Adults—At first, one 200 milligrams (mg) Viramune® immediate-release tablet once a day for 2 weeks. This is followed by one 400 mg Viramune® XR® once a day, together with other HIV medicines.

Children 6 to 17 years of age—Dose is based on body size and must be determined by your doctor. The starting dose is 150 milligrams (mg) per square meter (m[2]) of Viramune® oral suspension or tablets for the first 2 weeks. This is followed by 200 to 400 mg of Viramune® XR® once a day, together with other HIV medicines.

Children younger than 6 years of age—Use is not recommended.

For oral dosage forms (suspension or tablets):

Adults—200 milligrams (mg) once a day for 2 weeks, followed by 200 mg two times per day, together with other medicines.

Children and infants 15 days of age and older—Dose is based on body size and must be determined by your doctor.

Infants younger than 15 days of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of nevirapine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using nevirapine

It is very important that your doctor check the progress of you or your child at regular visits to make sure that nevirapine is working properly. Blood tests may be needed to check for unwanted effects.

Liver problems may occur while you are using nevirapine. Check with your doctor right away if you or your child are having more than one of these symptoms: abdominal pain or tenderness; clay-colored stools, dark urine, a fever, a headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, or yellow eyes or skin.

Tell your doctor if you or your child get any type of skin rash, even a mild rash. Stop using nevirapine and call your doctor right away if you or your child have a rash with blisters, a fever, mouth sores, red or irritated eyes, swelling of the face, muscle or joint pain, or muscle weakness.

Your immune system may get stronger, when you start taking HIV medicines. Tell your doctor right away if you or your child notice any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia, herpes, or tuberculosis. Autoimmune disorders (such as Graves' disease, polymyositis, and Guillain-Barré syndrome) may also occur.

nevirapine may cause you to have excess body fat. Tell your doctor if you or your child notice changes in your body shape, including an increased amount of body fat in your neck or upper back, face, around your chest, or stomach area. You might also lose fat from your legs, arms, or face.

nevirapine may decrease the effects of some birth control pills. To avoid getting pregnant, use an additional form of birth control along with your pills. Other forms of birth control include a condom, a diaphragm, contraceptive foam or jelly.

nevirapine does not decrease the risk of transmitting the HIV infection to others through sexual contact or by contaminated blood. Make sure you understand and practice safe sex, even if your partner also has HIV. Avoid sharing needles with anyone.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e. g. St. John's wort) or vitamin supplements.

nevirapine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Black, tarry stools

blistering, peeling, or loosening of the skin

chills

clay-colored stools

cough

dark urine

diarrhea

fever

general tiredness and weakness

itching

joint or muscle pain

light-colored stools

lower back or side pain

nausea and vomiting

painful or difficult urination

pale skin

red, irritated eyes

red skin lesions, often with a purple center

shortness of breath

skin rash

sore throat

sores, ulcers, or white spots in the mouth or on the lips

troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

upper right abdominal or stomach pain

yellow eyes and skin

Less common

Decreased appetite

hives

loss of appetite

swelling of the feet or lower legs

Rare

Abdominal or stomach pain

pain, numbness, or tingling of the hands, arms, legs, or feet

sleepiness or unusual drowsiness

tingling, burning, or prickly sensations

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Chest pain

cough

decrease in weight

dizziness or lightheadedness

feeling of constant movement of self or surroundings

headache

pain in the ankles or knees

painful, red lumps under the skin, mostly on the legs

sensation of spinning

trouble sleeping

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Difficulty with moving

muscle pain or stiffness

pain in the joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Truven Health Micromedex products as delivered by Drugs. com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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Men S Jewelry - Cool Men S Necklaces, Bracelets, Rings, Nackless

Men’s Jewelry

Shop Tribal Hollywood For

Cool Mens Jewelry

Find the coolest men's jewelry at Tribal Hollywood. We sell online the most unique selection of celebrity style mens necklaces, bracelets, and rings including biker, motorcycle, rocker, red carpet, and night club styles for men. Our VIP collection includes men's necklaces and pendants, men's rings, leather, bead, and silver mens bracelets, skull jewelry, silver chains, and dog tags. Choose from a variety of materials, including sterling silver, stainless steel, leather, and cobalt. You'll even find men's cufflinks, keychains, beaded rosaries, Celtic jewelry, and sunglasses. For divers, military, surfers, emergency responders, and other active men, we carry superior sports watches for men from Reactor Watches. The 316L stainless steel solid construction men's watches from Reactor come in chronograph, diver, military, waterproof, large face, sport, and rubber strap styles.

Our designer mens jewelry brands include King Baby jewelry and Scott Kay jewelry for men. Our King Baby line offers you superior craftsmanship and the tradition of biker and rocker jewelry, including rosary beads and crosses, skulls and more. The Scott Kay collection represents the art of wearable sculpture in truly unique and inspirational designs and features men's necklaces, bracelets, dog tags, rings and men's wedding bands. These designer collections also feature the best materials including 925 sterling silver, 18K gold, genuine black leather, black onyx stones, sapphires and more. Instantly get that edgy, rocker style your looking for with the high quality of fine men's jewelry engraved with a tough, bold look.

Tribal Hollywood showcases Bico Australia jewelry with special meanings, including astrology and zodiac designs, strength pendants, and popular styles under $20. Find Bico pendants meaning energy and wisdom, luck and good fortune and inspiration, and wear them with the popular tribal and warrior men's leather necklaces. Our MMA fans will appreciate Tribal Hollywood's original fight symbol necklaces MMA jewelry for ultimate fighters and ultimate fighting fans that sport mixed martial arts fashion. We also carry a large selection of bracelets and cuffs in stainless steel, leather, and sterling silver. Explore our large selection of men's jewelry and let your true rocker and celebrity tough guy style be front and center.

How To: A Men's Jewelry Guide

A Guide to Men's Jewelry

Becoming a jewelry clad man is a choice that dances a fine line between too much and not enough. If a man alters his basic traditional appearance to Mr. T, questions will be asked and stares will be cast in his direction. So how should a masculine figure complement his style with men's bracelets, or men's necklaces?

Men are stereotypically seen as the more rugged gender - tough skin, hardened eyes, and overall bigger bodies. So when it comes to choosing a piece of jewelry as a man, make sure to think about how YOU look in the piece and not that jacked model in the picture your girlfriend is ogling. Creating this image of "manly-man" requires selection of darker, hefty metals and materials.

In regards to metals, cobalt, sterling silver and titanium provide a touch of style while not being too sparkly or feminine. These metals are given an extra boost of allure when finishing styles are adjacently contrasted like with the DALTON Black Metal Titanium Mens Bracelet, or the BIBLE STUDY Titanium Mens Cross Bracelet. In addition to this, stainless steel is widely available in similar finishes, if you're not looking to break the bank. This braided coil men's bracelet from Hi-FI, is a great lower cost alternative to the Dalton bracelet, with many more stainless men's necklaces and bracelets in the store!

If looking for something non-metallic, then leather, dark stones, and naturally darker woods or with a dark stain should be the focus point. Women have white silk and shimmering gemstones to accent their dainty features, men's jewelry should be heartier and robust to enhance their masculine image. This can be achieved through something as simple as a leather cuff like the Ethereal Leather Cuff or a combination of multiple materials like Scott Kay's Black Onyx with Blue Apatite Bead Bracelet.

Style of Men's Jewelry

Once you've decided between leather, stone, and metal, style of the accessory is the most important factor to be able to wear men's jewelry successfully. If you are a small featured man, bulk up your features by going with a robust leather cuff, or a combined selection of men's bracelets that hang loosely from the hand. What we mean by this is that a small men's bracelet on a small wrist does not exude an air of masculinity. While on the other side of the scale, a thicker man needs to complement his already imposing stature with a small selection of hefty pieces. Basically, small bracelets and thin chains make it seem as though you are wearing your mom's jewelry. Pick your jewelry the way you make your chili; hearty.

How to Wear Men's Jewelry

Selecting men's jewelry can be a daunting task without the proper guide, but following these simple suggestions will give you the ability to round out whatever clothes you put on next! So the most important points to keep in mind and ask yourself when deciding to advance your appearance are as follows:

1. Start with one piece and build a collection

2. Make sure that the design is not too flashy

3. Does the design fit both your physical appearance and lifestyle?

4. Can your girlfriend make it look sexy?

Finding the right men’s jewelry can be tricky, but it really comes down to individual style and what you’re comfortable in. The perfect bracelet or necklace can be a worn accessory for many years and become a piece of identity.

Tribal Hollywood Reviews

Men’s Jewelry

Shop Tribal Hollywood For

Cool Mens Jewelry

Find the coolest men's jewelry at Tribal Hollywood. We sell online the most unique selection of celebrity style mens necklaces, bracelets, and rings including biker, motorcycle, rocker, red carpet, and night club styles for men. Our VIP collection includes men's necklaces and pendants, men's rings, leather, bead, and silver mens bracelets, skull jewelry, silver chains, and dog tags. Choose from a variety of materials, including sterling silver, stainless steel, leather, and cobalt. You'll even find men's cufflinks, keychains, beaded rosaries, Celtic jewelry, and sunglasses. For divers, military, surfers, emergency responders, and other active men, we carry superior sports watches for men from Reactor Watches. The 316L stainless steel solid construction men's watches from Reactor come in chronograph, diver, military, waterproof, large face, sport, and rubber strap styles.

Our designer mens jewelry brands include King Baby jewelry and Scott Kay jewelry for men. Our King Baby line offers you superior craftsmanship and the tradition of biker and rocker jewelry, including rosary beads and crosses, skulls and more. The Scott Kay collection represents the art of wearable sculpture in truly unique and inspirational designs and features men's necklaces, bracelets, dog tags, rings and men's wedding bands. These designer collections also feature the best materials including 925 sterling silver, 18K gold, genuine black leather, black onyx stones, sapphires and more. Instantly get that edgy, rocker style your looking for with the high quality of fine men's jewelry engraved with a tough, bold look.

Tribal Hollywood showcases Bico Australia jewelry with special meanings, including astrology and zodiac designs, strength pendants, and popular styles under $20. Find Bico pendants meaning energy and wisdom, luck and good fortune and inspiration, and wear them with the popular tribal and warrior men's leather necklaces. Our MMA fans will appreciate Tribal Hollywood's original fight symbol necklaces MMA jewelry for ultimate fighters and ultimate fighting fans that sport mixed martial arts fashion. We also carry a large selection of bracelets and cuffs in stainless steel, leather, and sterling silver. Explore our large selection of men's jewelry and let your true rocker and celebrity tough guy style be front and center.

How To: A Men's Jewelry Guide

A Guide to Men's Jewelry

Becoming a jewelry clad man is a choice that dances a fine line between too much and not enough. If a man alters his basic traditional appearance to Mr. T, questions will be asked and stares will be cast in his direction. So how should a masculine figure complement his style with men's bracelets, or men's necklaces?

Men are stereotypically seen as the more rugged gender - tough skin, hardened eyes, and overall bigger bodies. So when it comes to choosing a piece of jewelry as a man, make sure to think about how YOU look in the piece and not that jacked model in the picture your girlfriend is ogling. Creating this image of "manly-man" requires selection of darker, hefty metals and materials.

In regards to metals, cobalt, sterling silver and titanium provide a touch of style while not being too sparkly or feminine. These metals are given an extra boost of allure when finishing styles are adjacently contrasted like with the DALTON Black Metal Titanium Mens Bracelet, or the BIBLE STUDY Titanium Mens Cross Bracelet. In addition to this, stainless steel is widely available in similar finishes, if you're not looking to break the bank. This braided coil men's bracelet from Hi-FI, is a great lower cost alternative to the Dalton bracelet, with many more stainless men's necklaces and bracelets in the store!

If looking for something non-metallic, then leather, dark stones, and naturally darker woods or with a dark stain should be the focus point. Women have white silk and shimmering gemstones to accent their dainty features, men's jewelry should be heartier and robust to enhance their masculine image. This can be achieved through something as simple as a leather cuff like the Ethereal Leather Cuff or a combination of multiple materials like Scott Kay's Black Onyx with Blue Apatite Bead Bracelet.

Style of Men's Jewelry

Once you've decided between leather, stone, and metal, style of the accessory is the most important factor to be able to wear men's jewelry successfully. If you are a small featured man, bulk up your features by going with a robust leather cuff, or a combined selection of men's bracelets that hang loosely from the hand. What we mean by this is that a small men's bracelet on a small wrist does not exude an air of masculinity. While on the other side of the scale, a thicker man needs to complement his already imposing stature with a small selection of hefty pieces. Basically, small bracelets and thin chains make it seem as though you are wearing your mom's jewelry. Pick your jewelry the way you make your chili; hearty.

How to Wear Men's Jewelry

Selecting men's jewelry can be a daunting task without the proper guide, but following these simple suggestions will give you the ability to round out whatever clothes you put on next! So the most important points to keep in mind and ask yourself when deciding to advance your appearance are as follows:

1. Start with one piece and build a collection

2. Make sure that the design is not too flashy

3. Does the design fit both your physical appearance and lifestyle?

4. Can your girlfriend make it look sexy?

Finding the right men’s jewelry can be tricky, but it really comes down to individual style and what you’re comfortable in. The perfect bracelet or necklace can be a worn accessory for many years and become a piece of identity.

Tribal Hollywood Reviews



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Adipine Mr 10, Adipine

ADIPINE MR 10

Responses to RFI

Package leaflet: Information for the user TM

Adipine MR 10 and Adipine MR 20 modified release tablets Nifedipine

Adipine MR RET GEN UK GI / PIL

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor or pharmacist. • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

What is in this leaflet 1. What Adipine™ MR is and what it is used for 2. What you need to know before you take Adipine™ MR 3. How to take Adipine™ MR 4. Possible side effects 5. How to store Adipine™ MR 6. Contents of the pack and other information

1. What Adipine™ MR is and what it is used for Adipine™ MR contains the active substance nifedipine, which belongs to a group of medicines called calcium antagonists. Adipine™ MR is used to treat high blood pressure or angina (chest pain). For high blood pressure: Adipine™ MR works by relaxing and expanding the blood vessels. This makes the blood flow more easily and lowers blood pressure. Lower blood pressure reduces the strain on your heart. For angina: Adipine™ MR works by relaxing and expanding the arteries supplying the heart. This allows more blood and oxygen to reach the heart and decreases the strain on it. Your angina attacks will be less severe and less frequent if there is less strain on the heart.

2. What you need to know before you take Adipine™ MR Do NOT take Adipine™ MR • if you are allergic to the active substance, to any other similar medicines (known as dihydropyridines) or to any of the other ingredients of this medicine (listed in section 6). • if you have had a heart attack within the last month. • if you get a sudden angina attack. Adipine™ MR will not help relieve symptoms of angina quickly. • if you have unstable angina. • if you are taking rifampicin, an antibiotic. • if you have been told that you have a narrowing of the aortic heart valve (stenosis). • if you have ever had a collapse caused by a heart problem (cardiogenic shock), during which you became breathless, pale and had a cold sweat and dry mouth. • if your blood pressure continues to rise despite treatment (malignant hypertension). • If you have been told to avoid lactose, that you have a hereditary condition called Lapp lactase deficiency or glucose-galactose malabsorption. Warnings and precautions Talk to your doctor or pharmacist before taking Adipine™ MR. Your doctor will take special care: • If you have low blood pressure and you were prescribed Adipine™ MR for your angina. Your blood pressure may be decreased further by this treatment. • If you have a heart condition where your heart cannot cope with increased strain (poor cardiac reserve). • If you are pregnant. • If you are breastfeeding. If you need to take Adipine™ MR, you should stop breastfeeding before you start to take this medicine. • If you are a diabetic. The treatment for your diabetes may need to be adjusted. If you have any questions about this, ask your doctor. • If you are on kidney dialysis. If you have a very high blood pressure and a low blood volume, you might experience a sudden drop in blood pressure when you take Adipine™ MR. • If your liver is not working properly. Your doctor may need to do some blood tests. You may also be given a lower dose of Adipine™ MR. Tell your doctor: • If your chest pain (angina) gets worse (comes on more often or more severely) over a matter of hours or days. You may be advised not to take Adipine™ MR. • If you have chest pains after taking your first dose of Adipine™ MR. Your doctor may wish to change your treatment. • If you notice increased breathlessness. • If you notice swelling of the ankles. Tell your doctor before you take the next dose if any of these apply to you.

Also tell your doctor: • If you are giving a urine sample. Adipine™ MR may interfere with the results of certain urine tests. • If you are a man who has been unable to father a child by in vitro fertilisation. Drugs like Adipine™ MR have been shown to impair sperm function. Children and adolescents Adipine™ MR. is not recommended for use in children and adolescents below 18 years of age, because there are only limited data on the safety and efficacy in this population. Other medicines and Adipine™ MR Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Some medicines may affect the way Adipine™ MR works. Tell your doctor if you are taking: • Other medicines to treat high blood pressure. • Rifampicin (an antibiotic). • Cimetidine (to treat stomach ulcers). • Digoxin, diltiazem, quinidine or beta-blockers (to treat heart conditions). • Quinupristin/dalfopristin (a combination antibiotic). • Phenytoin, carbamazepine or valproic acid (to treat epilepsy). • Cisapride (to treat reduced movements of the gullet and stomach). • Magnesium sulphate injections during pregnancy (may cause a severe fall in blood pressure). • Erythromycin (an antibiotic). • Ketoconazole, itraconazole or fluconazole (anti-fungal medicines). • Indinavir, nelfinavir, ritonavir, saquinavir or amprenavir (to treat HIV). • Fluoxetine or nefazodone (to treat depression). • Tacrolimus (to prevent the rejection of transplanted organs). • Phenobarbital (usually used to treat insomnia or anxiety). Adipine™ MR with food and drink You can take Adipine™ MR with or without food. Do not drink grapefruit juice or eat grapefruit while taking Adipine™ MR. Do not start taking Adipine™ MR within 3 days of drinking grapefruit juice or eating grapefruit. Tell your doctor if you have had grapefruit or grapefruit juice in this time. Also, do not drink grapefruit juice or eat grapefruit whilst taking Adipine™ MR. Grapefruit juice is known to increase the blood levels of the active ingredient, nifedipine. This effect can last for at least 3 days. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. You may be able to use Adipine™ MR, but only after special consideration and agreement by your doctor. Do not take Adipine™ MR if you are breastfeeding. If you need to take Adipine™ MR, you should stop breastfeeding before you start taking the tablets. Driving and using machines Adipine™ MR, may make you feel dizzy, faint, extremely tired or have visual disturbances. Do not drive or operate machinery if you are affected in this way. This may be more likely when you first start treatment, if you change tablets, or if you have drunk alcohol. Adipine™ MR contains milk sugar (lactose) If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.

154 x 420 mm 6, 9, 10, 16 pt

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3. How to take Adipine™ MR Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. Adults Unless otherwise specified, the recommended starting dose is 10 mg Adipine™ MR every 12 hours. This may be increased to the maximum dose of 40 mg every 12 hours if necessary. Your doctor may increase or decrease the dose

Adipine_MR_RET_GEN_UK_GI_154x420_Mock-up_1507.qxp_1 05.10.15 08:23 Seite 2

Nifedipine 10 / 20 mg depending on how well your blood pressure or angina is being controlled. Older people Lower doses may be prescribed for older people. Hepatic impairment If you have problems with your liver your doctor will monitor you carefully. A reduction in your nifedipine dose may be required Use in children and adolescents Adipine™ MR is not recommended for use in children and adolescents below 18 years of age, because there are only limited data on the safety and efficacy in this population. Method of administration Swallow the tablets whole with a little water. You can take Adipine™ MR either with or without food. Do not take them with grapefruit juice. Duration of treatment Continue to take the tablets for as long as your doctor has told you to. If you take more Adipine™ MR than you should Get medical help immediately. If possible, take your tablets or the box with you to show the doctor. Taking too many tablets may cause your blood pressure to become too low and your heartbeats to speed up or slow down. It may also lead to an increase in your blood sugar level or an increase in the acidity of your blood, swelling in the lungs, low blood oxygen levels and disturbances in consciousness, possibly leading to unconsciousness. If you forget to take Adipine™ MR Take your normal dose immediately and continue taking your tablets as prescribed, waiting 12 hours before taking your next dose. Do not take a double dose to make up for the missed dose. If you stop taking Adipine™ MR High blood pressure and angina pectoris require longterm treatment. Your doctor will monitor your progress and determine the duration of your treatment. If you wish to stop taking these tablets temporarily or permanently, you should consult your doctor. It is important to reduce the dose gradually, especially if you have been taking high doses. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects Like all medicines, this medicine can cause side effects, although not everybody gets them. For the assessment of the side effects the following frequency rating was used: Serious side effects If you notice: • Severe, sudden generalised allergic reaction including very rarely life-threatening shock (e. g. difficulty in breathing, drop of blood pressure, fast pulse), swelling (including potentially lifethreatening swelling of the airway) • other allergic reactions causing swelling under the skin (possibly severe and including swelling of the larynx that may result in a life-threatening outcome) • fast heart beat (tachycardia) • shortness of breath or difficulty breathing • mild to moderate allergic reactions • itching (possibly severe), a rash or hives Contact your doctor immediately and do not take the next dose as these may be the first signs of allergic reaction which may become severe. If you develop: a skin reaction or blistering / peeling of the skin and/or mucosal reactions (in the mouth/nose or at the penis/vagina) (Toxic Epidermal Necrolysis). Contact your doctor immediately before you continue treatment as these may be signs of a severe reaction. Less serious side effects Apart from the side effects listed above, these are the other side effects of Nifedipine, starting with the more common ones: Common (may affect up to 1 in 10 people): • headache • flushing • general feeling of being unwell • constipation • swelling, particularly of the ankles and legs Uncommon (may affect up to 1 in 100 people): • stomach pain (abdominal pain) • unspecific pain • chills • low blood pressure when standing up (symptoms include fainting, dizziness, light headedness, occasional palpitations, blurred vision and sometimes confusion) • fainting • irregular heartbeat (palpitations) • dry mouth • indigestion or upset stomach • wind (flatulence) • feeling sick (nausea) • muscle cramps • joint swelling

Responses to RFI

• sleep disorders • anxiety or nervousness • reddening of the skin • nose bleeds • nasal congestion • sensation of spinning or whirling motion (vertigo) • migraine • dizziness • trembling • increase in the need to pass water (urinate) • painful or difficult urination • inability to achieve or maintain an erection (impotence) • blurred vision • temporary increase in certain liver enzymes Rare (may affect up to 1 in 1,000 people): • pins and needles • inflammation of the gums, tender or swollen gums, bleeding gums Not known (frequency cannot be estimated from the available data): • vomiting • a reduction in the number of white blood cells (leucopenia) • a more severe decrease in a specific class of white blood cell (agranulocytosis) • increased blood sugar (hyperglycaemia) • decreased skin sensitivity (hypoaesthesia) • drowsiness (somnolence) • eye pain • chest pain (angina pectoris) • heartburn or indigestion (gastroesophageal sphincter insufficiency) • yellowing of the whites of the eyes or skin (jaundice) • sensitivity to light (photosensitivity allergic reaction) • small, raised areas of bleeding in the skin (palpable purpura) • joint pain • muscle pain All of these symptoms usually go away when treatment with Adipine™ MR is stopped. Reporting of side effects If you get any side effects talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the YellowCard Scheme at www. mhra. gov. uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.

5. How to store Adipine™ MR Keep this medicine out of sight and reach of children. Do not take this medicine after the expiry date which is stated on the carton and blister after “EXP”. The expiry date refers to the last day of that month. Store in the original package in a cool, dry place below 25°C. Nifedipine is light-sensitive. Once you remove the tablets from the packaging, you should not expose them to intensive light for prolonged periods of time. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

6. Contents of the pack and other information What Adipine™ MR contains • The active substance is nifedipine. Each Adipine™ MR 10 tablet contains 10 mg of nifedipine. Each Adipine™ MR 20 tablet contains 20 mg of nifedipine. • The other ingredients are lactose, microcrystalline cellulose, macrogol 6000, magnesium stearate, maize starch, hydroxypropylmethyl cellulose, polysorbate 80 (tween 80), talc, titanium dioxide (E171), red iron oxide (E172). What Adipine™ MR looks like and contents of the pack Adipine™ MR 10 and Adipine™ MR 20 modified release tablets are pink-coated round, slightly biconvex tablets with smooth surface. Adipine™ MR 10 and Adipine™ MR 20 are available in packs containing 10, 20, 30, 50, 56, 60 or 100 tablets. Blister packages are made of aluminium foil and PVC film. Not all packaging sizes may be marketed. Marketing Authorisation Holder and Manufacturer STADA Arzneimittel AG, Stadastrasse 2–18, 61118 Bad Vilbel, Germany Tel: +49 6101 603 0, fax: +49 6101 603 259, website: www. stada. de Distributor Chiesi Limited, 333 Styal Road, Manchester, M22 5LG, UK. This leaflet was last revised in July 2015. CP0031/3 1507 UK

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



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Lad1 - Ladinin-1 - Homo Sapiens (Human) - Lad1 Gene - Protein, Ladinin

Ladinin-1

Homo sapiens (Human)

Reviewed - Annotation score: <p>Annotation score: 4 out of 5</p> <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome.</p><p><a href='../manual/annotation_score' target='_top'>More. </a></p> Annotation score: 4 out of 5 - Experimental evidence at protein level i <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.</p><p><a href='../manual/protein_existence' target='_top'>More. </a></p>

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More. </a></p> Function i

Anchoring filament protein which is a component of the basement membrane zone. By similarity

<p>The <a href="http://www. geneontology. org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More. </a></p> GO - Molecular function i

<p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology. org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assay i

25468996

<p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology. org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statement i

9119369

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More. </a></p> Names & Taxonomy i

<p>Provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.</p><p><a href='../manual/protein_names' target='_top'>More. </a></p> Protein names i

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More. </a></p> Interaction i

<p>The <a href="http://www. geneontology. org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More. </a></p> GO - Molecular function i

<p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology. org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assay i

25468996

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)<br/><a href='/database/184'>More..</a> BioGrid i

Protein interaction database and analysis system<br/><a href='/database/51'>More..</a> IntAct i

Last modified: September 23, 2008 - v2

<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W. H. Flannery B. P. Teukolsky S. A. and Vetterling W. T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www. nrbook. com/b/bookcpdf. php">Numerical recipes in C 2nd ed. pp896-902, Cambridge University Press (1993)</a>)</p> Checksum: i 622E81B9412A924B

<p>Reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.</p><p><a href='../manual/sequence_caution' target='_top'>More. </a></p> Sequence caution i

The sequence AAD10849 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

<p>Describes natural variant(s) of the protein sequence.</p><p><a href='../manual/variant' target='_top'>More. </a></p> Natural variant i



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receipt

Did You Know?

These days it may seem odd to speak of "grandma's cookie receipt," but at one time the only meaning of "receipt" was "recipe." The first recorded use of "receipt" is a reference to a medicinal preparation in Chaucer's Canterbury Tales (c. 1386). "Recipe" didn't arrive until the 1500s, and it was also first used to describe medicine. Both words began to be applied to cooking only in the 18th century, after which "recipe" slowly became the preferred word. "Receipt" acquired its currently more familiar sense of "a written statement saying that money or goods have been received" in the 17th century. Both "receipt" and "recipe" are thought to be ultimately derived from Latin recipere ("to receive"), making them probable relatives as well as synonyms.

Origin and Etymology of receipt

Middle English receite, from Anglo-French, from Medieval Latin recepta, probably from Latin, neuter plural of receptus, past participle of recipere to receive

First Known Use: 14th century

Recit

recit , ( French: “narrative” or “account”) a brief novel, usually with a simple narrative line. One of the writers who consciously used the form was Andre Gide. Both L’Immoraliste (1902; The Immoralist ) and La Porte etroite (1909; Strait Is the Gate ) are examples of the recit . Both are studiedly simple but deeply ironic tales in which the first-person narrator reveals the inherent moral ambiguities of life by means of seemingly innocuous reminiscences. Another example of a recit is Albert Camus ’s La Chute (1956; The Fall ).

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Buy Online Recit, Recit

Mefloquine Side Effects In Detail, Mefloquina

Mefloquine Side Effects

For the Consumer

Applies to mefloquine: oral tablet

In addition to its needed effects, some unwanted effects may be caused by mefloquine. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking mefloquine:

Rare

Aching joints and muscles

anxiety

blistering, loosening, peeling, or redness of the skin

chest pain or discomfort

chills

confusion

convulsions (seizures)

cough or hoarseness

dizziness

fainting

fever

hallucinations (seeing, hearing, or feeling things that are not there)

irregular, pounding, slow, or fast heartbeat or pulse

irritability

lightheadedness

lower back or side pain

mental depression

painful or difficult urination

pinpoint red spots on the skin

red or irritated eye

restlessness

sore throat

sores, ulcers, or white spots in the mouth or on the lips

stiff neck

swelling of the ankles, feet, or lower legs

unusual bleeding or bruising

unusual tiredness or weakness

vomiting

Incidence not known:

Blurred or loss of vision

continuing ringing or buzzing or other unexplained noise in the ears

disturbed color perception

double vision

feeling of constant movement of self or surroundings

halos around lights

hearing loss

hearing problems

loss of balance

loss of bladder control

muscle spasm or jerking of all extremities

night blindness

overbright appearance of lights

sensation of spinning

severe or continuing headache

sudden loss of consciousness

trouble sleeping

troubled breathing

tunnel vision

Minor Side Effects

Some of the side effects that can occur with mefloquine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

Diarrhea

emotional problems

nausea

stomach pain

Less common:

Abnormal dreams

loss of appetite

skin rash

Rare

Loss of hair

Incidence not known:

Acid or sour stomach

belching

flushing or redness of the skin

heartburn

indigestion

skin rash with a general disease

stomach discomfort, upset, or pain

swelling

unusually warm skin

For Healthcare Professionals

Applies to mefloquine: oral tablet

General

At the doses used for treatment of acute malaria infections, the side effects possibly associated with mefloquine cannot be distinguished from the side effects usually associated with the disease. The most common side effects reported during treatment included dizziness, myalgia, nausea, fever, headache, vomiting, chills, diarrhea, skin rash, abdominal pain, fatigue, loss of appetite, and tinnitus.

The most common side effects reported during malaria prophylaxis included vomiting (3%).

Due to the long half-life of mefloquine, side effects may occur and persist up to several weeks after drug discontinuation. [Ref ]

Psychiatric

Psychiatric side effects have included emotional problems and transient emotional disturbances. Behavioral changes, strange or vivid dreams, mania, nightmares, delusions, tension, anger, organic psychosis, and dysphoria have been reported. Sleep disorders (abnormal dreams), anxiety, depression, mood swings, panic attacks, aggression, psychotic or paranoid reactions, suicidal ideation, and suicide have been reported during postmarketing experience. [Ref ]

Gastrointestinal

Gastrointestinal side effects have included vomiting, nausea, diarrhea, abdominal pain, and loss of appetite. Mouth ulcers and anorexia have been reported. Nausea, vomiting, abdominal pain, loose stools or diarrhea, dyspepsia, and loss of appetite have been reported during postmarketing experience. [Ref ]

Nervous system

Nervous system side effects have included dizziness, syncope, headache, tinnitus, and seizures. Encephalopathy of unknown etiology was reported during prophylactic mefloquine administration; however, the relationship to drug administration could not be established. Weakness and myoclonus have been reported. Dizziness or vertigo, headache, loss of balance, somnolence, sleep disorders (insomnia), sensory and motor neuropathies (including paresthesia, tremor, ataxia), convulsions, agitation or restlessness, memory impairment, confusion, hallucinations, and encephalopathy, and vestibular disorders (including tinnitus and hearing impairment) have been reported during postmarketing experience. [Ref ]

Cardiovascular

Cardiovascular side effects have included extrasystoles and bradycardia. Cardiopulmonary arrest was reported in one patient after a single prophylactic dose while concomitantly using propranolol. Transitory and clinically silent electrocardiograph alterations (including sinus bradycardia, sinus arrhythmia, first degree atrioventricular block, prolongation of the QTc interval, and abnormal T waves) and atrial flutter have been reported. Circulatory disturbances (hypotension, hypertension, flushing, syncope), chest pain, tachycardia or palpitation, bradycardia, irregular heart rate, extrasystoles, atrioventricular block, and other transient cardiac conduction alterations have been reported during postmarketing experience. [Ref ]

Hematologic

A 56-year-old male experienced thrombotic thrombocytopenic purpura (TTP) coincident with mefloquine therapy. One week before admission, the patient developed weakness, followed some days later by anorexia, myalgia, and lethargy, and, finally, by fever, confusion, and blurred vision. A central venous catheter was placed in the right jugular vein and two plasmapheresis sessions (12 units of fresh frozen plasma) were conducted in the first 24 hours. Neurological status improved after the first plasmapheresis; hematological abnormalities disappeared in the first few days of therapy. For this patient, the presence of severe neurological symptoms together with fever, thrombocytopenia, and microangiopathic anemia suggested a more complex hematological abnormality, such as TTP. The causal relation between drug and disease is supported by the temporal relation of drug intake with the onset of the clinical symptoms and laboratory abnormalities, as well as by their prompt improvement after the aphaeretic therapy and drug withdrawal. [Ref ]

Hematologic side effects have included decreased hematocrit, leukopenia, leukocytosis, and thrombocytopenia. Anemia, at least 8 cases of isolated thrombocytopenia, at least five cases of hemolytic anemia, and at least one case of thrombotic thrombocytopenic purpura have been reported. Agranulocytosis and aplastic anemia have been reported during postmarketing experience. [Ref ]

Dermatologic

Dermatologic side effects have included skin rash, hair loss, pruritus, and telogen effluvium. Itching and cutaneous vasculitis have been reported. Rash, exanthema, erythema, urticaria, pruritus, hair loss, hyperhidrosis, erythema multiforme, and Stevens-Johnson syndrome have been reported during postmarketing experience. [Ref ]

Other

Other side effects have included asthenia, fatigue, fever, and chills. Asthenia, edema, malaise, fatigue, fever, and chills have also been reported during postmarketing experience. [Ref ]

Musculoskeletal

Musculoskeletal side effects have included myalgia. Moderately severe arthralgias and myalgias have been reported. Muscle weakness, muscle cramps, myalgia, and arthralgia have been reported during postmarketing experience. [Ref ]

Hypersensitivity

Hypersensitivity side effects have included hypersensitivity reactions ranging from mild cutaneous events to anaphylaxis. [Ref ]

Respiratory

Respiratory side effects have included dyspnea and pneumonitis of possible allergic etiology during postmarketing experience. At least one case of eosinophilic pneumonia has been reported. [Ref ]

A 67-year-old female with a history of pityriasis versicolor experienced eosinophilic pneumonia coincident with infliximab therapy. She was admitted because she had experienced high-grade fever (39 degrees Celsius), malaise, productive cough, and dyspnea on exertion during the previous week. She had traveled to South Africa for 8 weeks and had taken oral mefloquine 250 mg once every week as malaria prophylaxis. The therapy was continued for 4 weeks after she returned home. A thorough workup led to the diagnosis of eosinophilic pneumonia due to the mefloquine therapy. Her condition improved after the drug was withdrawn. [Ref ]

Hepatic

Hepatic side effects have included transient elevation of transaminases. Drug-related hepatic disorders from asymptomatic transient transaminase elevations to hepatic failure have been reported during postmarketing experience.

Ocular

Ocular side effects have included visual disturbances during postmarketing experience. [Ref ]

References

1. "Mefloquine for malaria." Med Lett Drugs Ther 31 (1990): 13-4

2. Winstanley P "Malaria: treatment." J R Coll Physicians Lond 32 (1998): 203-7

3. Jimenez-Huete A, Gil-Nagel A, Franch O "Multifocal myoclonus associated with mefloquine chemoprophylaxis." Clin Neuropharmacol 25 (2002): 243

4. Harinasuta T, Bunnag D, Wernsdorfer WH "A phase II clinical trial of mefloquine in patients with chloroquine-resistant falciparum malaria in thailand." Bull World Health Organ 61 (1983): 299-305

5. Bjorkman A "Acute psychosis following mefloquine prophylaxis." Lancet 2 (1989): 865

6. Speich r, Haller A "Central anticholinergic syndrome with the antimalarial drug mefloquine." N Engl J Med 331 (1994): 57-8

7. Meszaros K "Acute psychosis caused by mefloquine prophylaxis?" Can J Psychiatry 41 (1996): 196

8. Overbosch D, Schilthuis H, Bienzle U, et al. "Atovaquone-Proguanil versus Mefloquine for Malaria Prophylaxis in Nonimmune Travelers: Results from a Randomized, Double-Blind Study." Clin Infect Dis 33 (2001): 1015-21

9. Stuiver PC, Ligthelm RJ, Goud TJ "Acute psychosis after mefloquine." Lancet 2 (1989): 282

10. Eaton L "Mefloquine has more adverse effects than other drugs for malaria prophylaxis." BMJ 339 (2009): b4167

11. Croft AMJ, World MJ "Neuropsychiatric reactions with mefloquine chemoprophylaxis." Lancet 347 (1996): 326

12. Freedman DO "Clinical practice. Malaria prevention in short-term travelers." N Engl J Med 359 (2008): 603-12

13. Caillon E, Schmitt L, Moron P "Acute depressive symptoms after mefloquine treatment." Am J Psychiatry 149 (1992): 712

14. White NJ "Mefloquine." Br Med J 308 (1994): 286-7

15. Hennequin C, Bouree P, Bazin N, Bisaro F, Feline A "Severe psychiatric side effects observed during prophylaxis and treatment with mefloquine." Arch Intern Med 154 (1994): 2360-2

16. Van Riemsdijk MM, Ditters JM, Sturkenboom MC, et al. "Neuropsychiatric events during prophylactic use of mefloquine before travelling." Eur J Clin Pharmacol 58 (2002): 441-5

17. Rouveix B, Bricaire F, Michon C, et al "Mefloquine and an acute brain syndrome." Ann Intern Med 110 (1989): 577-8

18. White NJ, Pukrittayakamee S "Clinical malaria in the tropics." Med J Aust 159 (1993): 197-203

19. Weinke T, Trautmann M, Held T, et al "Neuropsychiatric side effects after the use of mefloquine." Am J Trop Med Hyg 45 (1991): 86-91

20. "Product Information. Lariam (mefloquine)." Roche Laboratories, Nutley, NJ.

21. Phillips M "Adverse events associated with mefloquine - women may be more susceptible to adverse events." BMJ 313 (1996): 1552-3

22. Brumbaugh M, Price P, Fagan N, Hsieh H "Psychotic mania associated with mefloquine in a bipolar patient." South Med J 101 (2008): 550-1

23. Piening RB, Young SA "Mefloquine-induced psychosis." Ann Emerg Med 27 (1996): 792-3

24. Bem JL, Kerr L, Stuerchler D "Mefloquine prophylaxis: an overview of spontaneous reports of severe psychiatric reactions and convulsions." J Trop Med Hyg 95 (1992): 167-79

25. Yelmo S, Morera-Fumero AL, Henry M, Renshaw A, Gracia-Marco R "Mania associated with mefloquine prophylaxis." J Clin Psychopharmacol 30 (2010): 339-41

26. Bakshi R, Hermeling-Fritz I, Gathmann I, Alteri E "An integrated assessment of the clinical safety of artemether-lumefantrine: a new oral fixed-dose combination antimalarial drug." Trans R Soc Trop Med Hyg 94 (2000): 419-24

27. ter Kuile FO, Nosten F, Thieren M, et al "High-dose mefloquine in the treatment of multidrug-resistant falciparum malaria." J Infect Dis 166 (1992): 1393-400

28. Lobel HO, Bernard KW, Williams SL, et al "Effectiveness and tolerance of long-term malaria prophylaxis with mefloquine: need for a better dosing regimen." JAMA 265 (1991): 361-4

29. Held T, Trautmann M, Weinke T, Mravak S "A prospective clinical trial of the treatment of falciparum malaria with mefloquine, with special reference to neuro-psychiatric side effects." Trans R Soc Trop Med Hyg 85 (1991): 444-5

30. Terkuile FO, Nosten F, Luxemburger C, Kyle D, Tejaisavatharm P, Phaipun L, Price R, Chongsuphajaisiddhi T, White NJ "Mefloquine treatment of acute falciparum malaria: a prospective study of non-serious adverse effects in 3673 patients." Bull World Health Organ 73 (1995): 631-42

31. Ekue JM, Ulrich A-M, Rwabwogo-Atenyi J, Sheth UK "A double-blind comparative clinical trial of mefloquine and chloroquine in symptomatic falciparum malaria." Bull World Health Organ 61 (1983): 713-8

32. De Souza J-M "A phase I clinical trial of mefloquine in brazilian male subjects." Bull World Health Organ 61 (1983): 809-14

33. Choo V "Uncertainty about mefloquine will take time to resolve." Lancet 347 (1996): 891

34. Olson PE, Kennedy CA, Morte PD "Paresthesias and mefloquine prophylaxis." Ann Intern Med 117 (1992): 1058-9

35. Singh K, Shanks GD, Wilde H "Seizures after mefloquine." Ann Intern Med 114 (1991): 994

36. Gullahorn GM, Bohman HR, Wallace MR "Anaesthesia emergence delirium after mefloquine prophylaxis." Lancet 341 (1993): 632

37. Ruff TA, Sherwen SJ, Donnan GA "Seizure associated with mefloquine for malaria prophylaxis." Med J Aust 161 (1994): 453

38. Jallon P "Use of mefloquine in epileptic patients." J Neurol Neurosurg Psychiatry 51 (1988): 732

39. Terkuile FO, Luxemburger C, Nosten F, Thwai KL, Chongsuphajaisiddhi T, White NJ "Predictors of mefloquine treatment failure: a prospective study of 1590 patients with uncomplicated falciparum malaria." Trans R Soc Trop Med Hyg 89 (1995): 660-4

40. Lench P "Malaria prophylaxis - psychological problems after mefloquine and chloroquine." BMJ 311 (1995): 192

41. Nosten F, ter Kuile FO, Luxemburger C, et al "Cardiac effects of antimalarial treatment with halofantrine." Lancet 341 (1993): 1054-6

42. Fonteyne W, Bauwens A, Jordaens L "Atrial flutter with 1:1 conduction after administration of the antimalarial drug mefloquine." Clin Cardiol 19 (1996): 967-8

43. Kozarsky P, Eaton M "Use of mefloquine for malarial chemoprophylaxis in its first year of availability in the United States." Clin Infect Dis 16 (1993): 185-6

44. Stracher AR, Stoeckle MY, Giordano HF "Aplastic anemia during malarial prophylaxis with mefloquine." Clin Infect Dis 18 (1994): 263-4

45. Fiaccadori E, Maggiore U, Rotelli C, et al. "Thrombotic-thrombocytopenic purpura following malaria prophylaxis with mefloquine." J Antimicrob Chemother 57 (2005): 160-1

46. Martin GJ, Malone JL, Ross EV "Exfoliative dermatitis during malarial prophylaxis with mefloquine." Clin Infect Dis 16 (1993): 341-2

47. Scerri L, Pace JL "Mefloquine-associated cutaneous vasculitis." Int J Dermatol 32 (1993): 517-8

48. Van Den Eden E, Van Gompel A, Colebunders R, Van Den Ende J "Mefloquine-induced Stevens-Johnson syndrome." Lancet 337 (1991): 683

49. White AC "Cutaneous vasculitis associated with mefloquine." Ann Intern Med 123 (1995): 894

50. Shlim DR "Severe facial rash associated with mefloquine." JAMA 266 (1991): 2560

51. Katsenos S, Psathakis K, Nikolopoulou MI, Constantopoulos SH "Mefloquine-induced eosinophilic pneumonia." Pharmacotherapy 27 (2007): 1767-71

Not all side effects for mefloquine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .



Buy Online Mefloquine Side Effects In Detail, Mefloquina

Tamoxen Side Effects In Detail, Tamoxen

Tamoxen Side Effects

For the Consumer

Applies to tamoxifen: oral solution, oral tablet

Because of the way this medicine acts on the body, there is a chance that it might cause unwanted effects that may not occur until months or years after the medicine is used. Tamoxifen increases the chance of cancer of the uterus (womb) in some women taking it. Tamoxifen may cause blockages to form in a vein, lung, or brain. In women, tamoxifen (the active ingredient contained in Tamoxen) may cause cancer or other problems of the uterus (womb). It also causes liver cancer in rats. In addition, tamoxifen has been reported to cause cataracts and other eye problems. Discuss these possible effects with your doctor.

As well as its needed effects, tamoxifen may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking tamoxifen, check with your doctor immediately:

Less common or rare:

Anxiety

blistering, peeling, or loosening of the skin and mucous membranes

blurred vision

cataracts in the eyes or other eye problems

change in vaginal discharge

chest pain

chills

confusion

cough

dizziness

fainting

fast heartbeat

fever

hoarseness

lightheadedness

lower back or side pain

pain or feeling of pressure in the pelvis

pain or swelling in the legs

pain, redness, or swelling in your arm or leg

painful or difficult urination

rapid shallow breathing

shortness of breath or trouble with breathing

skin rash or itching over the entire body

sweating

weakness or sleepiness

wheezing

vaginal bleeding

yellow eyes or skin

Incidence not known:

Bloating

constipation

darkened urine

diarrhea

difficulty with breathing

indigestion

itching

joint or muscle pain

large, hard skin blisters

large hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs

loss of appetite

nausea

pain in the stomach or side, possibly radiating to the back

red, irritated eyes

red skin lesions, often with a purple center

sore throat

sores, ulcers or white spots in the mouth or on the lips

unusual tiredness or weakness

vomiting

Minor Side Effects

Some tamoxifen side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:

Absent, missed, or irregular periods

decrease in the amount of urine

feeling of warmth

menstrual changes

noisy, rattling breathing

redness of the face, neck, arms and occasionally, upper chest

skin changes

stopping of menstrual bleeding

swelling of the fingers, hands, feet, or lower legs

troubled breathing at rest

weight gain or loss

white or brownish vaginal discharge

Less common or rare:

Abdominal or stomach cramps

black, tarry stools

bleeding gums

blood in the urine or stools

bluish color changes in skin color

bone pain

decreased interest in sexual intercourse

discouragement

feeling sad or empty

hair loss or thinning of the hair

headache

inability to have or keep an erection

irritability

itching in the genital area

loss of interest or pleasure

loss in sexual ability, desire, drive, or performance

nausea or vomiting (mild)

pain

pinpoint red spots on the skin

skin rash or dryness

stomach or pelvic discomfort, aching, or heaviness

swelling

trouble concentrating

trouble with sleeping

unusual bleeding or bruising

For Healthcare Professionals

Applies to tamoxifen: compounding powder, oral solution, oral tablet

General

In general, hot flashes, nausea, and vomiting have been the most commonly reported adverse effects, occurring in up to 25% of patients. [Ref ]

Oncologic

Oncologic side effects including numerous endometrial abnormalities have been reported with tamoxifen (the active ingredient contained in Tamoxen) use. These have included both endometrial adenocarcinoma (incidence rate per 1,000 women-years of 2.20 for tamoxifen versus 0.71 for placebo) and uterine sarcoma (incidence rate per 1,000 women-years of 0.17 for tamoxifen versus 0.04 for placebo). In most women treated with tamoxifen, the endometrium remains atrophic. However, hyperplasia, metaplasia, atypical hyperplasia, and endometrial polyps have also been reported. [Ref ]

The National Surgical Adjuvant Breast and Bowel Cancer (NSABP) B-14 trial evaluated the incidence of endometrial cancer in women with node-negative, estrogen receptor-positive, invasive breast cancer randomized to receive either placebo or tamoxifen 20 mg per day for five years after undergoing primary therapy. Compared with the placebo group, the relative risk of endometrial cancer among tamoxifen-treated women was 7.5.

In general, patients should be examined for preexisting endometrial lesions prior to starting tamoxifen therapy. The benefits and timing of routine endometrial screening, after initial scrounge, have yet to be defined. However, any postmenopausal bleeding or abnormal bleeding in premenopausal women should prompt a gynecological evaluation. [Ref ]

Genitourinary

Genitourinary side effects including endometriosis, vaginal bleeding, vaginal discharge, amenorrhea, altered menses, and oligomenorrhea have been reported in up to 24% of patients. However, these effects have rarely necessitated dosage reduction or drug withdrawal. Recurrent vulvovaginal candidiasis in postmenopausal women has been associated with long term treatment. Priapism and suppression of spermatogenesis have been reported in male patients treated with tamoxifen (the active ingredient contained in Tamoxen) [Ref ]

Musculoskeletal

Musculoskeletal side effects including pain and bone pain or bone "flare" have been reported in some patients following onset of tamoxifen (the active ingredient contained in Tamoxen) therapy and generally subside rapidly. Severe hypercalcemia or pancytopenia may occur in conjunction with these symptoms. In addition, patients with soft tissue disease may experience an initial increase in lesion size as well as local erythema during initiation of therapy. Other rheumatologic side effects have included a report of an acute, symmetrical inflammatory polyarthropathy. [Ref ]

Metabolic

Metabolic side effects have included severe hypercalcemia. Severe hypertriglyceridemia has been reported in one patient. The drug has been shown to inhibit bone turnover in women over 70 years old. [Ref ]

Life-threatening hypercalcemia may occur during initial therapy with tamoxifen in patients with bone metastases. Monitoring of serum calcium levels during early therapy is recommended for patients in whom bone metastases are present or are suspected. In cases of severe hypercalcemia, discontinuation of tamoxifen may be warranted, with reinstitution at a lower dose once calcium levels have normalized.

Bone mineral density studies have failed to find evidence of increased risk of osteoporosis in women treated with tamoxifen. One study noted a significant reduction in serum osteocalcin and alkaline phosphatase, indicating that tamoxifen may actually decrease the rate of trabecular bone resorption. [Ref ]

Hepatic

Hepatic side effects have included elevation in liver function tests, jaundice, peliosis hepatitis, steatohepatitis, cholestasis, and massive hepatic necrosis. While severe hepatic effects are rare, fatalities have been reported. [Ref ]

Hematologic

Hematologic side effects have been uncommon and have included thrombocytopenia (1%), leukopenia, and agranulocytosis. Two cases of cerebral sinus thrombosis have also been reported. Small, but clinically insignificant, decreases in antithrombin III and fibrinogen have been reported. [Ref ]

Ocular

A prospective study involving 63 patients evaluated the risk of ocular toxicity due to tamoxifen (the active ingredient contained in Tamoxen) 20 mg daily for a mean duration of 25 months (range: 6 to 51 months). Ocular toxicity, characterized by decreased visual acuity and retinopathy, occurred in 4 (6.3%) patients. Irreversible subepithelial corneal opacities were noted in one patient. Earlier reports suggested ocular toxicity was only associated with high-dose (>180 mg per day) therapy. However, this study and other recent case reports support a risk with currently accepted dosage regimens. [Ref ]

Ocular side effects including bilateral optic neuritis, retinopathy, and subepithelial opacities have been reported. Several cases of keratopathy have also been reported. [Ref ]

Cardiovascular

Several studies evaluating the effect of tamoxifen (the active ingredient contained in Tamoxen) on antithrombin III, fibrinogen, and platelets have been unable to provide clarification of thromboembolic risk in tamoxifen treated patients. In addition, despite its antiestrogenic activity, evidence is lacking to support a tamoxifen-associated increase in cardiovascular risk. One study concluded that tamoxifen and prior surgery, fracture, or immobilization were associated with a significantly increased risk of developing a venous thromboembolism. Another study found a decreased risk of myocardial infarction.

In one study of 8 premenopausal and 46 postmenopausal women with advanced breast cancer, tamoxifen 10 mg three times daily produced no effect on total cholesterol, triglycerides, or free fatty acids. A significant increase in HDL and subsequent increase in HDL/total cholesterol ratio were noted in addition to a significant reduction in LDL cholesterol. Overall, tamoxifen appeared to exert a favorable effect on the lipid profile.

One five year study has reported total serum cholesterol, LDL cholesterol, and lipoprotein to be significantly lower and apolipoprotein A1 levels significantly higher in 30 tamoxifen recipients compared with the 32 patients who did not receive tamoxifen. Apolipoprotein B levels were reported to have increased to a greater extent in the group which did not receive tamoxifen. After five years, fibrinogen level decreases and triglyceride level increases in the tamoxifen group were of borderline statistical significance. In general, the favorable changes in the lipid, lipoprotein, and fibrinogen levels seen early in tamoxifen therapy in postmenopausal women were reported to have continued to be seen five years into the treatment regimen. [Ref ]

Cardiovascular side effects including stroke (incidence rate per 1,000 women years was 1.43 for tamoxifen versus 1.00 for placebo) have been reported. Hot flushes (which may be severe in up to 22.7% of patients), edema (25%), phlebitis (1%), and thromboembolism have also been reported. [Ref ]

Respiratory

Respiratory side effects including pulmonary embolism (incidence rate per 1,000 women-years was 0.75 for tamoxifen (the active ingredient contained in Tamoxen) versus 0.25 for placebo) have been reported. Cough as well as a case of exacerbation of asthma have also been reported. [Ref ]

Endocrine

Endocrine side effects have included elevations in T4 in the absence of clinical hyperthyroidism. This may be due to tamoxifen-induced elevations in circulating thyroid binding globulin. In addition, tamoxifen (the active ingredient contained in Tamoxen) suppresses prolactin release in response to breast stimulation in puerperal women. Up to 30% of male breast cancer patients may experience a decrease in libido when treated with tamoxifen. [Ref ]

Psychiatric

Psychiatric side effects including depression and delusional syndromes have been reported rarely. [Ref ]

Immunologic

Immunologic side effects have included a case report of purpuric vasculitis. [Ref ]

Rechallenge with tamoxifen resulted in reappearance of lesions. [Ref ]

Other

Other side effects have included radiation recall and anorexia. [Ref ]

Tamoxifen-induced anorexia has been associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA. [Ref ]

Dermatologic

Dermatologic side effects including four cases of hair loss have been reported. One of those cases involved tamoxifen-induced total alopecia. A case of repigmentation following graying of the hair in a 68-year-old patient has also been reported. [Ref ]

Nervous system

One study has reported that when compared to healthy controls who were not using the drug, tamoxifen (the active ingredient contained in Tamoxen) users exhibited significantly worse performance on visual memory, word fluency, immediate verbal memory, visuo-spatial ability, and processing speed tasks. [Ref ]

Nervous system side effects including adverse cognitive effects have been reported. [Ref ]

References

1. Jaiyesimi IA, Buzdar AU, Decker DA, Hortobagyi GN "Use of tamoxifen for breast cancer: twenty-eight years later." J Clin Oncol 13 (1995): 513-29

2. Ellis PM, Tattersall MHN "Tamoxifen flare - an unusual case of hypercalcaemia and transient rapidly progressive pancytopenia." Aust N Z J Med 25 (1995): 375-6

3. "Product Information. Nolvadex (tamoxifen)." Zeneca Pharmaceuticals, Wilmington, DE.

4. Andersson M, Storm HH, Mouridsen HT "Carcinogenic effects of adjuvant tamoxifen treatment and radiotherapy for early breast cancer." Acta Oncol 31 (1992): 259-63

5. Friedl A, Jordan VC "What do we know and what don't we know about tamoxifen in the human uterus." Breast Cancer Res Treat 31 (1994): 27-39

6. Cohen I, Shapira J, Altaras M, Cordoba M, Rosen D, Beyth Y "Endometrial decidual changes in a postmenopausal woman treated with tamoxifen and megestrol acetate." Br J Obstet Gynaecol 99 (1992): 773-4

7. Fisher B, Costantino JP, Redmond CK, Fisher ER, Wickerham DL, Cronin WM, Bowman D, Couture J, Dimitrov NV, Evans J, Farrar "Endometrial cancer in tamoxifen-treated breast cancer patients - findings from the national surgical adjuvant breast and bowel project (NSABP) b-14." J Natl Cancer Inst 86 (1994): 527-37

8. Seoud MA, Johnson J, Weed JC "Gynecologic tumors in tamoxifen-treated women with breast cancer." Obstet Gynecol 82 (1993): 165-9

9. Dilts PV, Jr Hopkins MP, Chang AE, Cody RL "Rapid growth of leiomyoma in patient receiving tamoxifen." Am J Obstet Gynecol 166 (1992): 167-8

10. Timmerman D, Vergote I "Tamoxifen-induced endometrial polyp." N Engl J Med 335 (1996): 1650

11. Jordan VC, Morrow M "Should clinicians be concerned about the carcinogenic potential of tamoxifen?" Eur J Cancer 30A (1994): 1714-21

12. Ugwumadu AH, Bower D, Ho PK "Tamoxifen induced adenomyosis and adenomyomatous endometrial polyp." Br J Obstet Gynaecol 100 (1993): 386-8

13. Stewart HJ "The Scottish trial of adjuvant tamoxifen in node-negative breast cancer." Natl Cancer Inst Monogr 11 (1992): 117-20

14. Fornander T, Cedermark B, Mattsson A, et al. "Adjuvant tamoxifen in early breast cancer: occurrence of new primary cancers." Lancet 21 (1989): 117-20

15. Gal D, Kopel S, Bashevkin M, Lebowicz J, Lev R, Tancer ML "Oncogenic potential of tamoxifen on endometria of postmenopausal women with breast cancer--preliminary report." Gynecol Oncol 42 (1991): 120-3

16. Van Leeuwen FE, Benraadt J, Coebergh JW, et al. "Risk of endometrial cancer after tamoxifen treatment of breast cancer." Lancet 343 (1994): 448-52

17. Mack T "Tamoxifen ruling in California." Science 270 (1995): 1102-3

18. Ismail SM "Pathology of endometrium treated with tamoxifen." J Clin Pathol 47 (1994): 827-33

19. Ismail SM "The effects of tamoxifen on the uterus." Curr Opin Obstet Gynecol 8 (1996): 27-31

20. Wysowski DK, Honig SF, Beitz J "Uterine sarcoma associated with tamoxifen use." N Engl J Med 346 (2002): 1832-3

21. Committee on Gynecologic Practice "Tamoxifen and endometrial cancer." Int J Gynaecol Obstet 53 (1996): 197-9

22. Fornander T, Hellstrom AC, Moberger B "Descriptive clinicopathologic study of 17 patients with endometrial cancer during or after adjuvant tamoxifen in early breast cancer." J Natl Cancer Inst 85 (1993): 1850-5

23. Mccluggage WG, Varma M, Weir P, Bharucha H "Uterine leiomyosarcoma in patient receiving tamoxifen therapy." Acta Obstet Gynecol Scand 75 (1996): 593-5

24. Ribeiro G, Swindell R "The Christie Hospital adjuvant tamoxifen trial." Natl Cancer Inst Monogr 11 (1992): 121-5

25. Kang J, Baxi L, Heller D "Tamoxifen-induced growth of leiomyomas: a case report." J Reprod Med 41 (1996): 119-20

26. Barakat RR "Tamoxifen and endometrial neoplasia." Clin Obstet Gynecol 39 (1996): 629-40

27. Magriples U, Naftolin F, Schwartz PE, Carcangiu ML "High-grade endometrial carcinoma in tamoxifen-treated breast cancer patients." J Clin Oncol 11 (1993): 485-90

28. Wickerham DL, Fisher B, Wolmark N, et al. "Association of Tamoxifen and Uterine Sarcoma." J Clin Oncol 20 (2002): 2758-2760

29. Cross SS, Ismail SM "Endometrial hyperplasia in an oophorectomized woman receiving tamoxifen therapy. Case report." Br J Obstet Gynaecol 97 (1990): 190-2

30. Neven P, Demuylder X, Vanbelle Y, Campo R, Vanderick G "Tamoxifen and the uterus." BMJ 309 (1994): 1313-4

31. Coleman MP "Safety of tamoxifen." Lancet 347 (1996): 836-7

32. Corley D, Rowe J, Curtis MT, Hogan WM, Noumoff JS, Livolsi VA "Postmenopausal bleeding from unusual endometrial polyps in women on chronic tamoxifen therapy." Obstet Gynecol 79 (1992): 111-6

33. Divers MJ "Massive endometrial polyp after tamoxifen therapy." Br J Clin Pract 49 (1995): 275-6

34. Cuenca RE, Giachino J, Arrendondo MA, Hempling R, Edge SB "Endometrial carcinoma associated with breast carcinoma: low incidence with tamoxifen use." Cancer 77 (1996): 2058-63

35. Ford MR, Turner MJ, Wood C, Soutter WP "Endometriosis developing during tamoxifen therapy." Am J Obstet Gynecol 158 (1988): 1119

36. Rose PG, Alvarez B, MacLennan GT "Exacerbation of endometriosis as a result of premenopausal tamoxifen exposure." Am J Obstet Gynecol 183 (2000): 507-8

37. Glass AR "Paradoxical suppression of spermatogenesis during tamoxifen treatment of oligospermia." Fertil Steril 49 (1988): 376-7

38. Sobel JD, Chaim W, Leaman D "Recurrent vulvovaginal candidiasis associated with long-term tamoxifen treatment in postmenopausal women." Obstet Gynecol 88 (suppl (1996): 704-6

39. Court C "International group evaluates tamoxifen risks for women." BMJ 312 (1996): 529

40. "Tamoxifen under scrutiny as carcinogen in California." Eur J Cancer 32A (1996): 567

41. Thylan S "Tamoxifen-associated ovarian cysts may be endometriomas." Am J Obstet Gynecol 175 (1996): 752

42. Neven P "Endometrial changes in patients on tamoxifen." Lancet 346 (1995): 1292

43. Sasco AJ "Tamoxifen and menopausal status: risks and benefits." Lancet 347 (1996): 761

44. Fisher B "Commentary on endometrial cancer deaths in tamoxifen-treated breast cancer patients." J Clin Oncol 14 (1996): 1027-39

45. Mcgonigle KF, Lantry SA, Odommaryon TL, Chai A, Vasilev SA, Simpson JF "Histopathologic effects of tamoxifen on the uterine epithelium of breast cancer patients: analysis by menopausal status." Cancer Lett 101 (1996): 59-66

46. Fernando IN, Tobias JS "Priapism in patient on tamoxifen ." Lancet 1 (1989): 436

47. Cecchini S, Ciatto S, Bonardi R, Mazzotta A, Grazzini G, Pacini P, Muraca MG "Screening by ultrasonography for endometrial carcinoma in postmenopausal breast cancer patients under adjuvant tamoxifen." Gynecol Oncol 60 (1996): 409-11

48. Shushan A, Peretz T, Uziely B, Lewin A, Moryosef S "Ovarian cysts in premenopausal and postmenopausal tamoxifen-treated women with breast cancer." Am J Obstet Gynecol 174 (1996): 141-4

49. Agrawal BL, Zelkowitz L "Bone 'flare,' hypercalcemia, and jaundice after tamoxifen therapy ." Arch Intern Med 141 (1981): 1240

50. Creamer P, Lim K, George E, Dieppe P "Acute inflammatory polyarthritis in association with tamoxifen." Br J Rheumatol 33 (1994): 583-5

51. Kenny AM, Prestwood KM, Pilbeam CC, Raisz LG "The short term effects of tamoxifen on bone turnover in older women." J Clin Endocrinol Metab 80 (1995): 3287-91

52. Noguchi M, Taniya T, Tajiri K, Miwa K, Miyazaki I, Koshino H, Mabuchi H, Nonomura A "Fatal hyperlipaemia in a case of metastatic breast cancer treated by tamoxifen." Br J Surg 74 (1987): 586-7

53. Love RR, Bardon HS, Mazess RB, Epstein S, Chappell RJ "Effect of tamoxifen on lumbar spine bone mineral density in postmenopausal women after 5 years." Arch Intern Med 154 (1994): 2585-8

54. Fentiman IS, Caleffi M, Rodin A, Murby B, Fogelman I "Bone mineral content of women receiving tamoxifen for mastalgia." Br J Cancer 60 (1989): 262-4

55. Gibson TC "Severe hypercalcaemia and tamoxifen 'flare'." Br J Clin Pract 44 (1990): 716-7

56. Larsen W, Fellowes G, Rickman LS "Life-threatening hypercalcemia and tamoxifen." Am J Med 88 (1990): 440-2

57. Kalef-Ezra J, Glaros D, Klouvas G, Hatzikonstantinou J, Karantanas A, Siamopoulos KC, Pavlidis N "New evidence that tamoxifen does not induce osteoporosis: a nuclear activation analysis and absorptiometry study." Br J Radiol 65 (1992): 417-20

58. Neal AJ, Evans K, Hoskin PJ "Do long-term administration of tamoxifen affect bone mineral density." Eur J Cancer 29A (1993): 1971-3

59. Bruning PF, Bonfrer JM, Hart AA, de Jong-Bakker M, Linders D, van Loon J, Nooyen WJ "Tamoxifen, serum lipoproteins and cardiovascular risk." Br J Cancer 58 (1988): 497-9

60. Love RR, Mazess RB, Epstein S, Wiebe DA, Demets DL "Bone mineral density (BMD) preservation with tamoxifen treatment in postmenopausal women: results of a placebo-controlled trial (MEETING ABSTRACT)." Breast Cancer Res Treat 16 (1990): 145

61. Blackburn AM, Amiel SA, Millis RR, Rubens RD "Tamoxifen and liver damage." Br Med J (Clin Res Ed) 289 (1984): 288

62. Van Hoof M, Rahier J, Horsmans Y "Tamoxifen-induced steatohepatitis." Ann Intern Med 124 (1996): 855-6

63. Pratt DS, Knox TA, Erban J "Tamoxifen-induced steatohepatitis." Ann Intern Med 123 (1995): 236

64. Ching CK, Smith PG, Long RG "Tamoxifen-associated hepatocellular damage and agranulocytosis ." Lancet 339 (1992): 940

65. Pinto HC, Baptista A, Camilo ME, Decosta EB, Valente A, Demoura MC "Tamoxifen-associated steatohepatitis - report of three cases." J Hepatol 23 (1995): 95-7

66. Loomus GN, Aneja P, Bota RA "A case of peliosis hepatis in association with tamoxifen therapy." Am J Clin Pathol 80 (1983): 881-3

67. Love RR, Surawicz TS, Williams EC "Antithrombin III level, fibrinogen level, and platelet count changes with adjuvant tamoxifen therapy." Arch Intern Med 152 (1992): 317-20

68. Mike V, Currie VE, Gee TS "Fatal neutropenia associated with long-term tamoxifen therapy." Lancet 344 (1994): 541-2

69. Pavlidis NA, Petris C, Briassoulis E, Klouvas G, Psilas C, Rempapis J, Petroutsos G "Clear evidence that long-term, low-dose tamoxifen treatment can induce ocular toxicity. A prospective study of 63 patients." Cancer 69 (1992): 2961-4

70. Zinchuk O, Watanabe M, Hayashi N, Fukushima A, Ueno H "A case of tamoxifen keratopathy." Arch Ophthalmol 124 (2006): 1046-8

71. Bentley CR, Davies G, Aclimandos WA "Tamoxifen retinopathy: a rare but serious complication." BMJ 304 (1992): 495-6

72. Griffiths MF "Tamoxifen retinopathy at low dosage." Am J Ophthalmol 104 (1987): 185-6

73. Mihm LM, Barton TL "Tamoxifen-induced ocular toxicity." Ann Pharmacother 28 (1994): 740-2

74. Heier JS, Dragoo RA, Enzenauer RW, Waterhouse WJ "Screening for ocular toxicity in asymptomatic patients treated with tamoxifen." Am J Ophthalmol 117 (1994): 772-5

75. Pugesgaard T, Von Eyben FE "Bilateral optic neuritis evolved during tamoxifen treatment." Cancer 58 (1986): 383-6

76. Morales M, Santana N, Soria A, Mosquera A, Ordovas J, Novoa J, Betancor P, Valeron PF, Diazchico B, Chirino R "Effects of tamoxifen on serum lipid and apolipoprotein levels in postmenopausal patients with breast cancer." Breast Cancer Res Treat 40 (1996): 265-70

77. Love RR, Cameron L, Connell BL, Leventhal H "Symptoms associated with tamoxifen treatment in postmenopausal women." Arch Intern Med 151 (1991): 1842-7

78. Mcdonald CC, Alexander FE, Whyte BW, Forrest AP, Stewart HJ "Cardiac and vascular morbidity in women receiving adjuvant tamoxifen for breast cancer in a randomised trial." BMJ 311 (1995): 977-80

79. Hendrick A, Subramanian VP "Tamoxifen and thromboembolism." JAMA 243 (1980): 514-5

80. Duggan C, Marriott K, Edwards R, Cuzick J "Inherited and acquired risk factors for venous thromboembolic disease among women taking tamoxifen to prevent breast cancer." J Clin Oncol 21 (2003): 3588-93

81. Love RR, Wiebe DA, Feyzi JM, Newcomb PA, Chappell RJ "Effects of tamoxifen on cardiovascular risk factors in postmenopausal women after 5 years of treatment." J Natl Cancer Inst 86 (1994): 1534-9

82. Jones AL, Powles TJ, Treleaven JG, Burman JF, Nicolson MC, Chung HI, Ashley SE "Haemostatic changes and thromboembolic risk during tamoxifen therapy in normal women." Br J Cancer 66 (1992): 744-7

83. Smith RP, Dewar JA, Winter JH "Tamoxifen-induced asthma ." Lancet 341 (1993): 772

84. Masala A, Delitala G, Lo Dico G, Stoppelli I, Alagna S, Devilla L "Inhibition of lactation and inhibition of prolactin release after mechanical breast stimulation in puerperal women given tamoxifen or placebo." Br J Obstet Gynaecol 85 (1978): 134-7

85. Anelli TFM, Anelli A, Tran KN, Lebwohl DE, Borgen PI "Tamoxifen administration is associated with a high rate of treatment - limiting symptoms in male breast cancer patients." Cancer 74 (1994): 74-7

86. Gordon D, Beastall GH, McArdle CS, Thomson JA "The effect of tamoxifen therapy on thyroid function tests." Cancer 58 (1986): 1422-5

87. Ron IG, Inbar MJ, Barak Y, Stier S, Chaitchik S "Organic delusional syndrome associated with tamoxifen treatment." Cancer 69 (1992): 1415-7

88. Drago F, Arditi M, Rebora A "Tamoxifen and purpuric vasculitis ." Ann Intern Med 112 (1990): 965-6

89. Parry BR "Radiation recall induced by tamoxifen ." Lancet 340 (1992): 49

90. Lopez M, Lelliott CJ, Tovar S, et al. "Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA." Diabetes 55 (2006): 1327-1336

91. Puglisi F, Aprile G, Sobrero A "Tamoxifen-induced total alopecia." Ann Intern Med 134 (2001): 1154-5

92. Hampson JP, Donnelly A, Lewisjones MS, Pye JK "Tamoxifen-induced hair colour change." Br J Dermatol 132 (1995): 483-4

93. Palmer JL, Trotter T, Joy AA, Carlson LE "Cognitive effects of Tamoxifen in pre-menopausal women with breast cancer compared to healthy controls." J Cancer Surviv 2 (2008): 275-82

It is possible that some side effects of Tamoxen may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.



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Moltoben Para Que Sirve, Moltoben

Moltoben

Acceso rapido al contenido

Especial antencion con menores de 12 anos

Tenga especial cuidado durante el embarazo .

No usar Moltoben con lactantes.

Revise siempre que no sea alergico a ninguno de los componentes de Moltoben . podria poner en peligro su salud

Recuerda antes de tomar este medicamento consultar siempre con su medico, la informacion que ofrecemos es orientativa y no sustituye en ningun caso la de su medico u otro profesional de la salud.

Prospecto e indicaciones

Antidepresivo, inhibidor de la recaptacion de serotonina

COMPOSICION

MOLTOBEN

® 20: Cada cAp­sula contiene 20 mg de clorhidrato de fluoxetina.

DESCRIPCION

MOLTOBEN®(fluoxetina Bu­s­sie). La actividad antidepresiva de la fluoxetina y su meta­bolito activo norfluoxetina, se puede atribuir a su capacidad para facilitar la neu­rotransmi­sion serotoninergica, a traves de una potente y selectiva inhi­bicion de la recaptacion presinaptica de serotonina.

MOLTOBEN

® no interactua con los re­cep­tores muscarinicos, histaminergicos H1 o alfaadre­ner­gicos y presenta una baja incidencia de efectos anticolinergicos sin alterar los intervalos de conduccion cardiaca en pacientes con enfermedad cardio­vascular.

FARMACOCINETICA

MOLTOBEN® se absor­be muy bien en presen­cia o no de alimentos. Se requiere de un periodo de una a cuatro semanas para el inicio de su actividad farmacologica.

INDICACIONES

Depresion, desordenes obsesivocompulsivos y bulimia.

CONTRAINDICACIONES

Hipersensibilidad a la fluoxetina, embarazo, lactancia y en menores de 12 anos. MOLTOBEN® no debe administrarse con­comitan­te­mente con I. M.A. O. ni durante 14 dias despues de suspendida la administracion de estos medicamentos (vease Interac­ciones).

PRECAUCIONES Y ADVERTENCIAS

La administracion de MOLTOBEN® debera interrumpirse cuando se presente erupcion cutanea u otro fenomeno alergico. El riesgo/beneficio debera considerarse cuando exista: Diabetes mellitus, disminucion de la funcion hepatica o renal e historia de desordenes convulsivos. La administracion continua de MOLTOBEN® conduce a anorexia y perdida de peso que puede ser mayor de 5% del peso cor­-po­ral total. Aproximadamente en 1% de los pacientes puede observarse la aparicion de mania o hipomania. Debera establecerse una cuidadosa supervision de los pacientes deprimidos y con tendencias suicidas. Pacientes con severo compro­miso de la funcion renal o insuficiencia hepatica, requieren disminucion de la cantidad o la frecuencia de administracion del medicamento. Debe recomendarse cautela en la operacion de automoviles o maquinaria peligrosa, hasta que los pacien­tes tengan certeza de que la fluoxetina no esta interviniendo con su actividad motora o cognitiva. Efectos secundarios: Nauseas, cefalea, nerviosismo, insomnio o somnolencia, ansiedad, diarrea, temblores, sudoracion, sequedad de boca, vertigo, constipacion y disturbios de la vision, han sido reportados con alguna frecuencia. En administracion prolongada, la frecuencia de efectos adversos tiende a declinar, a excepcion del insom­nio (5-9%), el cual puede ser causa de interrupcion de la terapia. Otros efectos secundarios reportados son: Suenos anormales, alteraciones del gusto, tos, disminucion del apetito, perdida de peso, vomito, disminucion de la capacidad sexual, sensacion de calor, enrojecimiento de cara y cuello, dolor y calambres ab­do­minales, miccion frecuente, cansancio y debilidad. Raramente perdida del pelo, ganancia de peso y reactivacion de herpes simple.­ Ma­nifes­taciones que requieren de atencion medica: Escalofrios o fiebre, rash cutaneo, prurito, urticaria, mialgias o artralgias, disnea, reac­ciones alergicas incluso anafilaxia, convul­siones, mania o hipomania, glaucoma, secrecion inadecuada de hormona antidiure­tica, hipona­tremia e hipoglucemia, convulsiones, manifestaciones extrapi­ramidales e ideacion suicida. SobredosificaciOn: A diferencia de los antide­presivos triciclicos, la ingestion de grandes dosis de fluoxetina produce pocas evidencias de toxicidad y los sintomas de agitacion e inquietud, convulsiones, hipomania, nauseas y vomitos severos, remiten en general de manera espontanea. Existe un minimo riesgo de complicaciones car­diovascu­lares o neurologicas. El tratamiento de la sobredosificacion es general­mente sintomatico y de soporte; fluoxetina no es dializable. Interacciones medicamentosas: La administracion de un I. M.A. O. antes de las cinco semanas de suspendida la terapia, puede resultar en serios efectos adversos como: confusion, agitacion, inquietud, hiper­pirexia y crisis hiper­tensivas. Concomitan­te­mente con anti­depresivos trici­clicos, trazadona, maprotilina o alcohol eleva las concentraciones plasmaticas de estos compuestos. Fluoxetina prolonga la vida media de eliminacion del diazepam, aunque las respuestas sicomotoras no suelen afectarse. Existe riesgo potencial de incremento de los efectos adversos con medicamentos de alta union pro­teica, especialmente anticoagulantes, digita­licos y litio. Se han reportado convulsiones prolongadas ­ cuando fluo­xetina se usa concomi­tantemente con terapia electrocon­vulsiva, haloperidol, loxatadi­na, pentazocina, molindona o pimozida. El uso concomitante de fluoxetina con triptofano puede potencializar sintomas como inquietud, agitacion y problemas gastro­intes­tinales. Las concentraciones plasmaticas del litio y fenitoina pueden llegar a niveles toxicos si se administra con­comitante­mente con fluoxetina. Interferencias diagnOsticas: La fluoxetina puede alterar el control de la glucemia en pacientes diabeticos; se ha presentado hipoglu­cemia durante el tratamiento o incluso despues de suspendida la administracion; un ajuste en la dosificacion de la insulina y/o antidiabeticos orales puede ser necesario.

Como tomar

Adultos: 20 mg/dia dosis unica en la manana. La dosis puede incrementarse en 20 mg/dia despues de varias semanas, segun necesidad y tolera­bili­dad. Dosis mayores a 20 mg/dia deberan tomarse en 2 dosis divididas en la manana y en la noche. Dosis maxima: 80 mg/dia. Geriatria: Igual a los adultos, sin sobrepasar de 60 mg/dia. Pediatria: No se ha establecido la eficacia y seguridad de fluoxetina.

PRESENTACION

Caja con 20 capsulas de 20 mg.

HERPES . Es el nombre de una familia de virus que producen las llagas o fuegos del area de la boca (culebrillas) (Herpes Simplex y Herpes zoster, respectivamente).



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Wigraine (Oral, Wigraine

Wigraine

What is caffeine and ergotamine?

Caffeine is a stimulant that causes narrowing of blood vessels (vasoconstriction).

Ergotamine is in a group of drugs called ergot alkaloids (ER-got AL-ka-loids). It works by narrowing the blood vessels around the brain. Ergotamine also affects blood flow patterns that are associated with certain types of headaches.

Caffeine and ergotamine is a combination medicine used to treat or prevent a migraine type headache.

This medication will only treat a headache that has already begun. It will not prevent migraine headaches or reduce the number of attacks.

Caffeine and ergotamine should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches.

Caffeine and ergotamine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about caffeine and ergotamine?

This medication can harm an unborn baby or cause birth defects. Do not use if you are pregnant.

You should not use caffeine and ergotamine if you have coronary heart disease, high blood pressure, circulation problems, liver or kidney disease, or a serious infection called sepsis.

Some medicines can cause a dangerous decrease in blood flow when used with caffeine and ergotamine. A severe decrease in blood flow to the brain and other parts of the body can lead to dangerous side effects.

Tell your doctor about all medicines you use, and those you start or stop using, especially: atazanavir, boceprevir, clarithromycin, delavirdine, fosamprenavir, imatinib, indinavir, isoniazid, itraconazole, ketoconazole, nefazodone, nelfinavir, nicardipine, posaconazole, quinidine, ritonavir, saquinavir, telaprevir, telithromycin, or voriconazole.

What should I discuss with my healthcare provider before using caffeine and ergotamine ?

You should not use this medicine if you are allergic to caffeine or ergotamine, if you are pregnant, or if you have:

coronary heart disease;

high blood pressure;

blood circulation problems;

kidney disease; or

a serious infection called sepsis.

Some medicines can cause a dangerous decrease in blood flow when used with caffeine and ergotamine. A severe decrease in blood flow to the brain and other parts of the body can lead to dangerous side effects. Your doctor may need to change your treatment plan if you use any of the following drugs:

an antibiotic--clarithromycin, telithromycin;

antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

heart medication--nicardipine, quinidine;

hepatitis C medications--boceprevir, telaprevir; or

HIV/AIDS medication--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.

FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use caffeine and ergotamine if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medication.

Caffeine and ergotamine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

How should I use caffeine and ergotamine?

Follow all directions on your prescription label. Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. This medicine is not for daily use.

To use caffeine and ergotamine tablets:

Take 2 tablets of caffeine and ergotamine as soon as you notice headache symptoms, or after an attack has already begun.

If your headache does not completely go away, you may take 1 more tablet after at least 30 minutes have passed.

If additional medication is needed, you may take 1 tablet every 30 minutes up to a total of 6 tablets for one migraine attack.

If you still have migraine symptoms after taking a total of 6 tablets, call your doctor. Do not take more than a total of 6 tablets in any 24-hour period. Do not take more than a total of 10 tablets over a period of 7 days.

Do not take a rectal suppository by mouth. It is for use only in your rectum.

Wash your hands before and after inserting the rectal suppository.

To use caffeine and ergotamine rectal suppositories:

Insert 1 suppository at the first sign of migraine headache symptoms, or after an attack has already begun.

Remove the wrapper before inserting the suppository. Avoid handling the suppository too long or it will melt in your hands.

Lie on your back with your knees up toward your chest. Gently insert the suppository into your rectum about 1 inch.

For best results, stay lying down for a few minutes. The suppository will melt quickly and you should feel little or no discomfort while holding it in. Avoid using the bathroom just after using the suppository.

If your headache does not completely go away, use 1 more suppository after at least 1 hour has passed.

If you still have migraine symptoms after using a total of 2 rectal suppositories, call your doctor. Do not use more than a total of 2 suppositories per headache. Do not use more than a total of 5 suppositories over a period of 7 days.

Do not share this medication with another person, even if they have the same symptoms you have.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since caffeine and ergotamine is used only when needed, you are not likely to miss a dose.

Do not take more than 6 caffeine and ergotamine tablets per day or more than 10 tablets per week.

Do not use more than 2 suppositories per headache or 5 suppositories per week.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of caffeine and ergotamine can be fatal.

What should I avoid while using caffeine and ergotamine?

Do not use caffeine and ergotamine within 24 hours before or after using another migraine headache medicine, including:

dihydroergotamine, ergonovine, or methylergonovine; or

almotriptan, eletriptan, frovatriptan, naratriptan, sumatriptan, rizatriptan, or zolmitriptan.

Grapefruit and grapefruit juice may interact with caffeine and ergotamine and lead to unwanted side effects. Avoid the use of grapefruit products while taking caffeine and ergotamine.

Caffeine and ergotamine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using caffeine and ergotamine and call your doctor at once if you have:

weak pulses in your arms and legs, numbness and tingling or pain in your hands or feet, blue-colored fingers or toes;

painful sores on your rectum after using the rectal suppositories;

sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

fast or slow heart rate;

leg weakness, muscle pain in your arms or legs;

severe pain in your stomach or lower back;

little or no urinating;

chest discomfort, dry cough or hack, feeling short of breath on exertion; or

dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Common side effects may include:

dizziness, spinning sensation;

nausea, vomiting; or

mild itching or swelling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect caffeine and ergotamine?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with caffeine and ergotamine, especially:

an antibiotic--ciprofloxacin, doxycycline, erythromycin, metronidazole, norfloxacin, tetracycline;

antifungal medication--clotrimazole, fluconazole, voriconazole;

an antidepressant--desipramine, fluoxetine, fluvoxamine, sertraline;

diet pills, stimulants, or ADHD medication;

heart or blood pressure medication--amiodarone, diltiazem, dronedarone, lidocaine, propranolol, verapamil;

HIV/AIDS medication--atazanavir, fosamprenavir, efavirenz, darunavir when given with ritonavir, saquinavir; or

medicines to treat asthma, colds or allergies.

This list is not complete. Other drugs may interact with caffeine and ergotamine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

More about Wigraine (caffeine / ergotamine)

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about caffeine and ergotamine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 4.02. Revision Date: 2013-11-20, 10:34:03 AM.

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Inosine Uses, Side Effects, Interactions And Warnings, Inoxin

INOSINE

Overview

Inosine is a chemical that can be made in a laboratory. It is used as medicine.

People take inosine for improving their athletic performance.

How does it work?

There is information that suggests inosine might help nerve branches (axons) grow from healthy nerves to injured nerve cells in the brain and spinal cord. If this is true, inosine might be useful in treating spinal cord injuries, but more research in people is needed to be sure.

Uses

Likely InEffective for

Improving athletic performance.

Side Effects

It is not known if inosine is safe or what the possible side effects might be.

Special Precautions & Warnings:

Pregnancy and breast - feeding . Not enough is known about the use of inosine during pregnancy and breast - feeding. Stay on the safe side and avoid use.

Interactions

No data available at this time.

Dosing

The appropriate dose of inosine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for inosine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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Tylosin Phosphate - Mib #43 - Animals - Canadian Food Inspection Agency, Lignosol

Tylosin Phosphate - MIB #43

This page is part of the Guidance Document Repository (GDR).

Approved Brands

Tylan 10 Premix contains tylosin (as tylosin phosphate) at 22 g/kg (Elanco)

Tylan 40 Premix contains tylosin (as tylosin phosphate) at 88 g/kg (Elanco)

Tylan 100 Premix contains tylosin (as tylosin phosphate) at 220 g/kg (Elanco)

Tylosin 10 Premix contains tylosin (as tylosin phosphate) at 22 g/kg (Bio Agri Mix LP )

Tylosin 40 Premix contains tylosin (as tylosin phosphate) at 88 g/kg (Bio Agri Mix LP )

Pharmasin 100 Premix contains tylosin (as tylosin phosphate) at 220 g/kg (Huvepharma AD)

Approved for use

In meal or pellet feed for swine, broiler chickens and beef cattle.

Approved claims

For swine - Claims 1, 2, 3, 5, 7, 8 For beef cattle - Claim 4 For broiler chickens - Claim 6

Claim 1, 2, 3 and 4 – approved with the use of all premixes Claim 5, 6, 7 and 8 – approved with the use of all Tylan premixes, Tylosin 40 and Pharmasin 100 .

Note:

Positive diagnosis by a veterinarian is essential before using tylosin phosphate for the treatment and prevention of swine dysentery or porcine proliferative enteropathy, or for the treatment of necrotic enteritis in broiler chickens.

Claim 1: As an aid in treatment of Swine Dysentery (bloody scours, bloody diarrhea, black scours, hemorrhagic colitis, vibrio)

Level of Drug:

110 mg/kg (0.011%) tylosin in the complete feed.

Direction:

Feed this medicated feed as the sole ration for three weeks. Tylosin tartrate medicated drinking water should be provided concurrent with this medicated feed for the first three days of treatment or until symptoms disappear. Following this treatment, a prophylactic swine feed is to be fed.

Note:

Treatment following positive diagnosis involves placing the swine on medicated feed as well as water medication consisting of one gram of tylosin tartrate per 3.785 litres of drinking water. This should be given for three days or until symptoms disappear.

Warning:

Swine treated concurrently with this drug in the complete feed and with tylosin tartrate in drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with tylosin in drinking water.

Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)

Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)

When treating swine dysentery, the diagnosis should be redetermined in cases of lack of response within 3 to 5 days of treatment commencement.

Claim 2: As an aid in prevention of cyclic recurrence following treatment of Swine Dysentery. (bloody scours, bloody diarrhea, black scours, hemorrhagic colitis, vibrio)

Level of Drug:

44 mg/kg (0.0044%) tylosin in the complete feed.

Direction:

Feed this medicated feed as the sole ration until hogs reach market weight.

Note:

Swine Dysentery appears sporadically in swine herds in Canada.

Warning:

Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)

Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)

Claim 3: As an aid in the prevention of Porcine Proliferative Enteropathy (PPE) or ileitis associated with Lawsonia intracellularis

Level of Drug:

110 mg/kg (0.011%) tylosin in the complete feed.

Direction:

Feed this medicated feed as the sole ration for 21 days, commencing prior to an anticipated outbreak of disease.

Warning:

Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)

Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)

Claim 4: To reduce the incidence of liver abscesses caused by Arcanobacterium pyogenes (formerly Actinomyces pyogenes ) and Fusobacterium necrophorum in beef cattle (steers and heifers) fed in confinement for slaughter

Level of Drug in Complete Diet:

11 mg/kg (0.0011%) tylosin in the complete diet including roughage (100% Dry Matter Basis)

Direction:

Feed continuously as the sole ration.

Note:

Tylan 10 Premix, Tylan 40 Premix and Pharmasin 100 Premix are approved to be used in the following thixotrope liquid supplements:

HCS, Nutrena Feeds, Cargill Limited.

Promolas Liquid Supplement Suspension, Westway Feed Products

Warning:

Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

Do not feed to replacement, breeding or lactating cattle.

Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)

Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)

Do not use thixotropic supplements after four weeks storage. (Required on Cargill thixotropic liquid supplement labels only.)

Do not use thixotropic supplements after eight weeks storage. (Required on Promolas Liquid Supplement Suspension and Westway Feed Products thixotropic liquid supplement labels only.)

Claim 5: As an aid in the treatment of porcine proliferative enteropathy (PPE) or ileitis, associated with Lawsonia intracellularis when used following treatment with either Elanco Tylan Soluble, Tylosin Soluble Powder or Huvepharma Pharmasin Soluble

Level of Drug:

110 mg/kg (0.011%) tylosin in the complete feed.

Direction:

Feed this medicated feed as the sole ration for 7 days following treatment with Elanco Tylan Soluble or Tylosin Soluble Powder or Huvepharma Pharmasin Soluble.

Note:

Treatment following positive diagnosis involves placing the swine on water medication consisting of one gram of Elanco Tylan Soluble, Tylosin Soluble Powder or Huvepharma Pharmasin Soluble per 12 litres of drinking water (83 mg per litre) for 7 days followed by Elanco Tylan Premix, Bio Agri Tylosin 40 Premix or Huvepharma Pharmasin 100 Premix in feed at a rate of 110 mg/kg of complete feed for 7 days.

Warning:

Swine treated concurrently with this drug in the complete feed with either Elanco Tylan Soluble or Tylosin Soluble Powder or Huvepharma Pharmasin Soluble in drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with tylosin in drinking water.

Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)

Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)

Claim 6: As an aid in the treatment of necrotic enteritis caused by Clostridium perfringens in broiler chickens

Level of Drug:

200 mg/kg (0.020%) tylosin in the complete feed.

Direction:

Feed this medicated feed as the sole ration for 7 days.

Warning:

Do not use in laying hens.

Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)

Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)

When treating necrotic enteritis, the diagnosis should be redetermined in cases of lack of response within 3 to 5 days of treatment commencement.

Claim 7: For the treatment of porcine proliferative enteropathy (PPE) or ileitis, associated with Lawsonia intracellularis

Level of Drug:

110 mg/kg (0.011%) tylosin in the complete feed.

Direction:

Feed this medicated feed as the sole ration for three weeks.

Warning:

Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)

Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)

When treating Porcine Proliferative Enteropathy the diagnosis should be confirmed by a veterinarian when results are not satisfactory.

Claim 8: For the treatment of porcine proliferative enteropathy (PPE) or ileitis, associated with Lawsonia intracellularis in the presence of persistent or recurring infection

Level of Drug:

110 mg/kg (0.011%) tylosin in the complete feed for 3 weeks.

44 mg/kg (0.0044%) tylosin in the complete feed for the following 3 weeks.

Direction:

Feed 110 mg/kg (0.011%) medicated feed as the sole ration for 3 weeks This must be followed by 44 mg/kg medicated feed for the next 3 weeks.

Feed 44 mg/kg (0.0044%) medicated feed as the sole ration for 3 weeks only after having fed 110 mg/kg medicated feed for 3 weeks.

Warning:

Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)

Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)

When treating Porcine Proliferative Enteropathy the diagnosis should be confirmed by a veterinarian when results are not satisfactory.

Accepted Compatibilities

Tylosin phosphate is compatible with the following drug/drug combinations. For details, refer to the MIB as indicated.

For use in feed for



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Marvel Shop, Mavol

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Lamivudine Medlineplus Drug Information, Zeffix

Lamivudine

Lamivudine, when used alone or in combination with other antiviral medications, can cause serious damage to the liver and a condition called lactic acidosis. If you experience any of the following symptoms, call your doctor immediately: nausea, loss of appetite, excessive tiredness, weakness, dark yellow or brown urine, unusual bleeding or bruising, flu-like symptoms, yellowing of the skin or eyes, and pain in the upper right part of your stomach. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to lamivudine.

Epivir tablets and liquid (used to treat human immunodeficiency virus [HIV]) are not interchangeable with Epivir-HBV tablets and liquid (used to treat hepatitis B infection). Epivir contains a higher dose of lamivudine than Epivir-HBV. Treatment with Epivir-HBV in patients infected with HIV may cause the HIV virus to be less treatable with lamivudine and other medicines. If you have both HIV and hepatitis B, you should take only Epivir. If you are taking Epivir-HBV for hepatitis B infection, talk to your doctor about your risks for HIV infection.

Why is this medication prescribed?

Lamivudine (Epivir) is used along with other medications to treat human immunodeficiency virus (HIV) infection. Lamivudine (Epivir-HBV) is used to treat hepatitis B infection. Lamivudine is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV and hepatitis B in the blood. Although lamivudine does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting (spreading) the HIV virus to other people.

How should this medicine be used?

Lamivudine comes as a tablet and liquid to take by mouth. Lamivudine (Epivir) is usually taken every 12 hours (twice a day). Lamivudine (Epivir-HBV) is usually taken once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lamivudine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take lamivudine even if you feel well. Do not stop taking lamivudine without talking to your doctor.

Other uses for this medicine

Lamivudine is also used sometimes in combination with zidovudine (Retrovir, AZT) to treat healthcare workers or other individuals exposed to HIV infection after accidental contact with HIV-contaminated blood, tissues, or other body fluids. Talk to your doctor about the possible risks of using this drug for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking lamivudine,

tell your doctor and pharmacist if you are allergic to lamivudine or any other drugs.

tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially trimethoprim/sulfamethoxazole (Bactrim, Septra) and vitamins.

tell your doctor if you have or have ever had hepatitis B, kidney disease, or pancreas disease (in children only).

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking lamivudine, call your doctor. You should not breast-feed while taking lamivudine.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.



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Paracetamol G Gam, Influbene N

Paracetamol G Gam

Chemical Name

Chemical Formula

Other Brand Names

2-A

A-Mycin

A-Per

Abdine

Abrol

Abrolet

Acamol

Acamoli

Ace

Acecat

Acenol

Acephen

Acertol

Acet

Aceta

Acetafen

Acetagen

Acetalgin

Acetalis

Acetamin

Acetaminofen

Acetaminofen

Acetaminofen MK

Acetaminophen

Acetaminophen and Codeine Phosphate

Acetaminophen and Pentazocine hydrochloride

Acetamol

Acetazone Forte

Acetolit

Aceval

Actadol

Actol

Adalgur

Adco-Paracetamol

Adinol

Adol

Adol PM

Adol Sinus

Adolef

Adorem

Aeknil

Afebryl

Agurin

Aldolor

Algiafin

Algicalm

Alginox

Algisedal

Algocod

Algopirina

Algostase

Algostase mono

Algotropyl

Alikal

Alivax

Alphamol

Alvedon

Ametrex

Amifen

Amipar

Amol

Anacin

Anadin Paracetamol

Analgan

Analgiplus

Analper

Ananty

Andox

Anexsia

Anhiba

Anti-Gripe Asclepius

Antidol

Antigriphine

Antigrippine

Anyrume

APA

APAP

Apap C Plus

Apap Extra

Apap Noc

APC-Acetaminophen

Aphlogis

Apiret

Apiretal

Apiretal Codeina

Apo-Acetaminophen

Apo-Oxycodone/Acet

Aporex

Apotel

Apracur Granulado

Apyrene

Arfen

Arthrifen Plus

Asta

Atamel

Atasol

Atenemen

Atmiphen

ATP

Atralidon

Azur

Azur compositum

Baby Rinolo

Babyfever

Becetamol

Ben-u-ron

Benuron

Benylin Cold and Sinus

Beres Febrilin

Besemax

Besenol

Biogesic

Biogrip-T

Bodrex

Bodrex forte

Brexin

Buscopan compositum

Buscopan plus

Butapap

Calapol

Calonal

Calpol

Calpol 6 plus

Calpol Paediatric

Calsil

Capital and Codeine Phosphate

Captin

Catajap

Causalon

Cebion Febbre

Cefecon D

Cefekons

Cemol

Cetadol

Cetafrin

Cetal

Cetalgin

Cetamol

Chefarine

Children's Bufferin

Children's Panadol

Children's Tylenol

Citrosan

Claradol

Co-Becetamol

Co-Becetamol fur Kleinkinder

Co-Dafalgan

Co-Efferalgan

Cocarl

Cod Efferalgan

Codalgin

Codipar

Codipar Plus

Coditam

Coldrex Sinus

Contac

Contac Cold & Sore Throat, Non Drowsy

Contra-Schmerz P

Contraneural

Contratemp

Copyrkal

Cotibin Compuesto

Couldrex

Coxumadol

Crocin

Croix Blanche

Cupanol

Curadies Paracetamol

Curpol

Curpol Junior

Cytramon-P

Dafalgan

Dafalgan Bebe

Dafalgan C

Dafalgan Codeine

Dafalgan Enfant

Dafalgan Odis

Dafalgan Pediatrie

Dafalgan plus C

Daga

Daimeton

Daleron

Daleron C

Daleron C junior

Dalminette

Daro Hoofdpijnpoeder

Daro Paracetamol

Darvocet

Day & Night

Daygrip

Decolgen ACE

Demogripal C

Dentonibsa

Dentopain [+ Ibuprofen>

Depalgos

Depyrin

Dexamol

Dexamol Kid

Dhamol

Dialgine

Dimetapp Daytime Cold Extra Strength

Dirox

Disprol

Distalgesic

Doc Para

Docpara

Docparacod

Docpelin Paracetamol

Dolal

Dolel

Dolevar

Dolex

Dolgesic

Dolgesic Codeina

Doliprane

Dolitabs

Dolko

Dolocare

DoloCitran C

Dolofebril

Dolol Instant

Dolomedil

Dolomol

Dolomolargesico

Dolostop

Dolotec

Dolprone

Doluvital

Dolviran

Dopagan

Dopalgan

Dopalogan

Dopamol

Dorbigot

Doregrippin

Dorocol

Doxyfene

Dozol

Dristan N. D.

Dumin

Duokapton

Duorol

Dymadon

Efagesic

Eferalgan

Efetamol

Effect

Efferalgan

Efferalgan Vitamina C

Efferalganodis

Ekosetol

Emidol

Empacod

Empaped

Emtacetamol

Enddol

Endocet

Enelfa

Enelfa Dr. Henk

Erphamol

Espaven

Ethics Paracetamol

Expandox

FAP

Farmadol

Fast

Fea

Febrax

Febrectal

Febrectal Infantil

Febrex

Febricet

Febridol

Febrilix

Felibrix

Femerital

Fevac

Fevadol

Feverall

Fevrin

Fibrex

Fibrexin

Fibrimol

Filanc

Finimal

Finimal C

Fitamol

Flaviston E

Flectadol

Flogodisten

Fludeten

Fludrex

Fluental

Flutabs

Fortamol

Frenagial

Gabbrocet

Gamatherm

Gelocatil

Gelocatil Codeina

Gelonida

Geluprane

Genapap

Genebs

Geniol-P

Genspir

Geralgine-P

Getol

Gitas Plus

Go-Gesic

Gold Cross Paracetamol

Gripakin

Gripostad

Grippex

Grippostad

Grippostad Heissgetrank

Hapacol

Head-O

Hedex

Hepa

Hexplider-C

Hot Coldrex

Hydrocodone bitartrate and Acetaminophen

Ibumol

Ibupain

Infadrops

Infants' Feverall

Infants' Tylenol

Infapain

Influbene C

Influbene N

Intaflam

Iremax

Isalgen Compuesto

Itamol

Itedal

Ixprim

Jagcin

Junior Parapaed

Kafa

Kafa Flashtabs

Kafa plus Koffein

Kapake

Kelvin

Kenox

Kinderparacetamol

Kinderparacetamol CF

Kitadol

Kodipar

Kolibri

Korylan

Lanamol

Lekadol

Lemgrip

Lemsip

Lensen

Liquiprin

Lisopan

Lonarid

Lortab

Lotem

Lupocet

Lusadeina

Mafidol

Mafidol Compuesto

Maganol

Magnidol

Malex

Malidens

Mann

Medamol

Medibudget Schmerztabletten Paracetamol

Medinol

Medinol Paediatric

Medipyrin

Mejorax

Mejorax Infantil

Methoxacet

Mexalen

Midol Night-Time

Midrid

Midrone

Migraeflux MCP

Migralave + MCP

Migrane-Neuridal

Migranerton

Minafen

Minofen

Minoset

Miralgin

Momentum

Muscadol

Myogesic

Mypaid

N-Paracetamol

Nactop

Napa

Napacod

Napafen

Napamol

Naprex

Nasa

Nasamol

Nedolon

Neo Rheumacyl

Neomol

Neopap

Neopyrin

Neverdol

Niocitran

Nodipir

Nodrof

Norco

Norflex CO

Norgesic

Normotemp

Novalsung

Novo Asat

Novo-Gesic

Nufadol

Nuosic

Octadon

Omol

Optalidon Schmerztabletten

Optipyrin

Oskadon

Ottopan

Oxycet

Oxycodone and Acetaminophen

Pacimol

Painamol

Painamol Plus

Paldesic

Pamol

Pamol Flash

Panacare

Panacetamol

Panadeine

Panado

Panadol

Panadol 7+ years

Panadol Actifast

Panadol Adultos

Panadol Antigrippine

Panadol Artrose

Panadol Baby

Panadol Baby & Infant

Panadol C

Panadol Codeine

Panadol Extend

Panadol Extra

Panadol Femina

Panadol Infantil

Panadol Junior

Panadol Night

Panadol Plus

Panadol Rapide

Panadol Zapp

Panaflam

Panagesic Adultos

Panagesic Infantil

Panam Retard

Panamax

Panaram

Panasorbe

Panasorbe (Sanofi-Aventis - Produtos farmaceuticos, S.)

Panets

Panets Baby

Panodil

Panodil Zapp

Para

Para-C

Para-don

Para-G

Para-Suppo

Para-Tabs

Para-z-mol

Paracap

Paracare

Paracen

Paraceon

Paracet

Paracetam

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Private dining at PAZO is perfect for business, social, or just for fun, we specialize in celebrations, presentations and more. PAZO is Baltimore's premier private event location for small intimate affairs to groups of 350. We welcome you to reserve one of our lounge seating areas, private rooms, or the entire restaurant for your next event.

Whether you're looking for a warm and inviting space or something on a grander scale, the management and service staff at PAZO are prepared to assist in creating events that provide wonderful memories of your special occasion or business affair. PAZO is open for dinner service seven days a week starting at 5pm through closing. For select occasions, we are pleased to accommodate breakfast meetings, luncheons and full restaurant buy-outs.

Click here to download a PDF of our private dining room options

When emailing, please consider including the following: your phone number, date of your event, number of guests, and any other information that can help us help you better! PRIVATE ROOMS PAZO offers two private rooms for your exclusive use. With built in plasma screens, the Avellino and Villa Rosa are perfect for business presentations, meetings and private events. Both spaces are located on the spectacular mezzanine at PAZO. LOUNGE & MAIN DINING AREA Enjoy the expansive and lively atmosphere at PAZO for business networking, social gatherings or a special night out.

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PAZO provides an extraordinary backdrop for weddings and commitment ceremonies for up to 350 guests. From your rehearsal dinner to vows to your reception, the romantic setting is perfect as you indulge in sophisticated southern Italian cuisine and an award-winning wine list. This unique venue features vaulted ceilings, rich jewel-toned décor, iron chandeliers, plush seating and a 500 square foot dance floor.

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Upcoming Events

$5 Happy Hour

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Cleocin is used for treating serious infections caused by certain bacteria. Cleocin is a lincomycin antibiotic. Cleocin kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

Use Cleocin as directed by your doctor.

Take Cleocin by mouth with or without food.

Take Cleocin with a full glass of water (8 oz/240 mL).

Cleocin works best if it is taken at the same time each day.

To clear up your infection completely, take Cleocin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Cleocin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Cleocin.

Store Cleocin at room temperature, between 68 to 77 degrees F (20 to 25 degrees C) in a tightly-closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cleocin out of the reach of children and away from pets.

Active Ingredient: Clindamycin hydrochloride.

Do NOT use Cleocin if:

you are allergic to any ingredient in Cleocin or to lincomycin

you have certain intestinal problems (eg, antibiotic-associated colitis, Crohn disease, ulcerative colitis) or meningitis.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Cleocin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, or a history of liver problems or stomach or bowel problems (eg, colitis)

if you are allergic to tartrazine.

Some medicines may interact with Cleocin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Nondepolarizing muscle relaxants (eg, vecuronium) or succinylcholine because the risk of their side effects may be increased by Cleocin.

Erythromycin because it may decrease Cleocin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cleocin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Cleocin only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use Cleocin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Cleocin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

This product may contain tartrazine dye. This may cause an allergic reaction in some patients. If you have ever had an allergic reaction to tartrazine, ask your pharmacist if your product has tartrazine in it.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Cleocin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Cleocin with caution in the elderly; they may be more sensitive to its effects, especially diarrhea.

Use Cleocin with extreme caution in children younger 10 years who have diarrhea or an infection of the stomach or bowel.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cleocin while you are pregnant. Cleocin is found in breast milk. If you are or will be breast-feeding while you use Cleocin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Mild diarrhea; nausea; vomiting.

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This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Fluohexal

Fluoxetine hydrochloride is an antidepressant drug used medically in the treatment of depression, obsessive-compulsive disorder, bulimia nervosa, premenstrual dysphoric disorder and panic disorder. Fluoxetine is also used (off-label) to treat many other conditions, such as ADHD. more.

It is sold under the brand names Prozac ®, Symbyax ® (compounded with olanzapine), Sarafem ®, Fontex ® (Sweden), Foxetin ® (Argentina), Ladose ® (Greece), Fluctin ® (Austria, Germany), Prodep ® (India), Fludac *® (India) and Lovan ® (Australia). Fluoxetine was derived from diphenhydramine, an antihistamine found to inhibit reuptake of the neurotransmitter serotonin.

Compared to other popular selective serotonin reuptake inhibitors, fluoxetine has a strong energizing effect. This makes fluoxetine highly effective in treatment of clinical depression cases where symptoms like depressed mood and lack of energy prevail. Although stimulating, it is also approved for a variety of anxiety disorders, including panic disorder and obsessive compulsive disorder.

Eli Lilly's Prozac was approved by the FDA on December 29, 1987 and introduced in the US at the beginning of 1988. The drug became very popular, with millions around the world having taken the medication. In the fall of 2001, Eli Lilly lost a patent dispute with Barr Laboratories and now fluoxetine hydrochloride is manufactured by many companies.

Uses

Approved

Fluoxetine hydrochloride is approved in the United States to treat depression, obsessive-compulsive disorder, bulimia nervosa, premenstrual dysphoric disorder and panic disorder. In the United Kingdom, it is approved to treat depression with or without anxiety, bulimia nervosa, and obsessive-compulsive disorder.

In December 2003 the FDA approved Symbyax® to treat bipolar depression. Symbyax is a combination of fluoxetine and olanzapine. (However, the pure form of fluoxetine can cause mania, mixed-states, rapid cycling and psychosis in bipolar patients, particularly if the patient is not also taking a mood stabilizer.)

Unapproved/Off-label/Investigational

In 2003, Michel Harper, Fukodome Takayasu, and Andrew G. Engel reported that fluoxetine given over a period of three years at doses of up to 80-120 mg/day to two patients with slow-channel congenital myasthenic syndrome who were allergic to quinidine resulted in substantial subjective and objective improvement in muscle strength.

Mechanism of action

Recent research indicates that fluoxetine may increase the production of new neurons (brain cells) in adult brain (adult neurogenesis). and that it interacts with the system of "clock genes". the transcription factors involved in drug abuse and possibly obesity.



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Merchandising & Operations Sharp and detail oriented people with an appreciation for craftsmanship and quality.

Brand & Marketing Creatives who think outside the box and know how to use both sides of the brain.

Web & Engineering Engineers and designers with a passion for UX and a love of great design.

LOST iN is an innovative travel guide, available through diverse mediums: print, web and mobile, it offers an inspiring and curated selection of recommendations sourced from local opinion leaders. Furthermore, through the mobile application, it offers travelers access to in­-destination services aimed at streamlining the travel experience. Carefully selected destinations, original insights from local experts and original in­-destination services create convenience and authenticity in traveling with LOST iN.

(4) OPEN POSITIONS If you are interested in one of the following positions we are looking forward to hear from you by mail. Send your CV with attached certificates as well as a motivational descriptive to jobs@lostin. com

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Being an intern at LOST iN is simply awesome. Not only will you get to make coffee for some of the most-gifted colleagues, you also get to do actual work. As a Graphic Designer, you will be responsible for our guides, ads and website. Your work covers near-infinite range of projects that engage with all elements of the Adobe package as Photoshop . In-Design and Illustrator .

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Very good German – and English skills

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LOST iN is hiring a full-time WordPress Guru to put our wicked website together. You’ll be part of our international team, comprised of some of the best-looking people in the world.

As our developer, you are responsible for building and maintaining our website. Your work covers near-infinite range of projects that engage with all elements as HTML, CSS, and WordPress . If you are eager to push the boundaries of what is possible with these languages, you should definitely join our team.

Knowledge is power. To excel in this role, you’ve got to know your way around libraries and languages within WordPress — let us know what you know.

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Have experience building WordPress themes & plugins using PHP, as well as possess e-commerce (WooCommerce) experience

You speak English fluently, German is a plus

Degree in (Mobile) Computer Engineer (or similar) / proven work experience

Integration of multiple data sources and databases into one system

Setup and administration of backups

Understanding differences between multiple delivery platforms such as mobile vs desktop, and optimizing output to match the specific platform

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If you’re interested in joining our team in Magdeburg, we’d love to hear from you. In return for your commitment to craft and code, we offer some of the most interesting (start-up) projects in the digital realm alongside a one-of-a-kind company culture.

Please be attentive to the requirements for this role and accompany your application with a short cover letter and portfolio to jobs@lostin. com detailing why you’re the right Developer for the job. We’re looking forward in hearing from you!

LOST iN is hiring a full-time Mobile Developer to put our wicked app together. You’ll be part of our international team, comprised of some of the best-looking people in the world.

You are responsible for building and maintaining our mobile iOs and Android app. This means you’ll need to be an expert at exterminating bugs and have the perseverance to outlive ever-improving iterations of the same app. So stop playing on your phone and send us your best application so far!

Translate designs and wire-frames into high quality code

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Degree in (Mobile) Computer Engineer (or similar) / proven work experience

Strong knowledge of Android and iOs, different versions, and how to deal with different screen sizes

Strong knowledge of UI/UX design principles, patterns, and best practices

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Experience with offline storage, threading, and performance tuning

Ability to understand business requirements and translate them into technical requirements and vice versa

A knack for bench marking and optimization

You speak English fluently, German is a plus

If you’re interested in joining our team in Magdeburg, we’d love to hear from you. In return for your commitment to craft and code, we offer some of the most interesting (start-up) projects in the digital realm alongside a one-of-a-kind company culture.

Please be attentive to the requirements for this role and accompany your application with a short cover letter and portfolio to jobs@lostin. com detailing why you’re the right Developer for the job. We’re looking forward in hearing from you!

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LOST iN is hiring a full-time BI analyst. You get to define the very essence of our product, design solutions to our customers problems and get to work with everyone in the business. You play a very large part in our business success!

LOST iN has an international and entrepreneurial work environment, where employees can and are expected to work independently. Also it is required to quickly take on responsibility and directly contribute to our growth and success with a passionate and innovative attitude. We are dedicated to build a team of highly motivated talents to help us grow and focus on the spread of LOST iN.

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You speak English fluently, German is a plus

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If you’re interested in joining our team in Magdeburg, we’d love to hear from you. In return for your commitment to craft, we offer some of the most interesting (start-up) projects in the digital realm alongside a one-of-a-kind company culture.

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Amilopid (Norvasc) Explicacion

Amilopid se hace a traves de los profesionales de la droga en tiendas con el fin de luchar contra anginas, asi como enfermedades de presion arterial alta. Concentrese en asociado con Amilopid seria para gestionar los problemas del corazon, asi como reducir el grado de presion arterial baja.

Amilopid puede pasar como un buen anti-angina de pecho, asi como el tratamiento anti-hipertension. Amilopid funciona a traves de la disminucion de la presion arterial baja, asi como el control de los problemas del corazon a traves de la oferta hacia el torrente sanguineo cardiovasculares. Usted podria hacer Amilopid junto con algunas otras formulaciones anti-hipertension.

Amilopid tambien puede ser referido como amlodipino besilato, Amlip, Avacard, Dailyvasc, Istin, Perivasc.

Amilopid es en realidad calcio bloqueador estacion de mineral.

titulo general asociada con Amilopid es en realidad amlodipino.

Marca asociada con Amilopid Amilopid es en realidad.

Amilopid (Norvasc) Dosis

Amilopid viene en:

segundo. 5mg Baja Dosis

material de friccion material de friccion dosis regular 5mg

10 mg Mejorado Dosis material de friccion

Es necesario llevarlo por via oral.

Es recomendable considerar Amilopid diaria al mismo tiempo.

Amilopid extras anginas, asi como enfermedades de la presion arterial alta y se utiliza cada uno a traves de los adultos a traves de los ninos.

Los ninos asocian con 17.6 muchos anos:

A partir dosis es en realidad la segunda. 5.5 miligramos.

Las personas con anginas vasoespasticas o incluso coronaria:

A partir dosis es en realidad metro setenta y cinco miligramos.

Seniors, individuos con insuficiencia hepatica:

A partir dosis es en realidad la segunda. cinco miligramos.

Si usted desea lograr mejores resultados por lo general no dejar de usar Amilopid, de repente.

Amilopid (Norvasc) Careciendo asocia con dosis

Por lo general, no reciben doble dosis. En caso de que salte la dosis que necesita para llevar una vez se tiene en cuenta en lo que respecta a su deficiente. Cuando es hora de la dosis que necesita para llevar a cabo su propia rutina de dosificacion normal.

Amilopid (Norvasc)

En el caso de que una sobredosis de Amilopid y que tambien se evita gran usted necesita comprobar hacia fuera su medico o incluso el medico de inmediato. Asociado con la sobredosis de Amilopid: desmayos, fatiga, latidos del corazon rapidos.

Amilopid (Norvasc) Espacio de almacenamiento

Tienda en temperaturas de espacio entre 10 y 30 niveles de D (59, asi como ochenta y seis niveles F) de la humedad, la iluminacion, asi como la temperatura. Mantener cuadro de texto firmemente cerrada. Fortalecer cualquier tipo de medicamento sin tocar a partir del dia de vencimiento. Mantener desde el lograr de los ninos dentro de un cuadro de texto que los ninos pequenos no puedan abrir.

Amilopid (Norvasc) Efectos negativos

Amilopid ofrece los efectos negativos. El mas tipico tienden a ser:

lavado material de friccion

material de friccion fatiga

material de friccion migrana

incomodidad asociada con material de friccion vientre

material de friccion vientre molesto

material de friccion somnolencia

material de friccion mareo

material de friccion fatiga

efectos negativos Mucho menos tipicos y graves en todo el uso de Amilopid:

respuestas reaccion alergica (urticaria, inhalando y exhalando, cuestiones de alergia, asi como material de friccion erupcion)

material de friccion desmayos Material

problemas cardiacos friccion

problemas de ritmo cardiaco material de friccion

Los efectos negativos indicaciones se basan en la medicacion que podria ser pero, ademas, el uso de confiar en su condicion de bienestar y otros aspectos.

Amilopid (Norvasc) Contraindicaciones

Por lo general no reciben Amilopid en caso de que son sensibles con el fin de elementos Amilopid.

Por lo general no reciben Amilopid si usted esta esperando otra manera tiene la intencion de tener un hijo. Por lo general, no utilizan una mama medica de alta level00.

Por lo general, no utilizan Amilopid en caso de lucha con estenosis aortica importante, sorpresa cardiogenico, asi como anginas inestables.

Juega el papel de cautela, junto con la utilizacion de Amilopid en caso de contraer enfermedades en el higado, fallo cardiovascular o incluso incapacidad hepatica.

Por lo general, no utilizan suplementos dieteticos de potasio o incluso alternativas de sodio.

Si usted desea lograr mejores resultados, sin efectos negativos, es aconsejable evitar las bebidas alcoholicas.

Hacerse cauteloso si usted esta viajando dispositivo.

Por lo general, no dejar de usar Amilopid, de repente.

Amilopid (Norvasc) Preguntas comunes

Queen: Exactamente ?que implica Amilopid?

El: Amilopid es una eficiente preparacion de gran alcance que se consume en la reparacion de las anginas, asi como la presion arterial alta illnesses. A

Queen: ?Que es exactamente la marca asociada con Amilopid?

El: titulo general asociada con Amilopid es en realidad amlodipino. Marca asociada con Amilopid es en realidad Amilopid. A

Queen: ?Que personas deberian evitar Amilopid?

El: Por lo general no utilizan Amilopid cuando usted esta esperando y esta amamantando. Por lo general, no utilizan Amilopid en caso de que son sensibles con el fin de elementos Amilopid. Por lo general, no utilizan Amilopid en caso de lucha con estenosis aortica importante, sorpresa cardiogenico, asi como inestable anginas. A

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Queen: ?Que es exactamente el enfoque sobre Amilopid?

El: Amilopid se hace a traves de los profesionales de la droga en tiendas con el fin de luchar contra anginas, asi como enfermedades de presion arterial alta. Enfoque en asociado con Amilopid seria para gestionar los problemas del corazon, asi como reducir el grado de baja en la sangre pressure. A

Queen: Que los ninos utilizar Amilopid?

El: De hecho, los ninos asociados con 17.6 muchos anos pueden usar. A partir dosis es en realidad la segunda. 5-5 miligrams. A

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Augmentin ohne rezept

Augmentin is used for treating infections caused by certain bacteria. Augmentin is a penicillin antibiotic. It works by killing sensitive bacteria.

Use Augmentin as directed by your doctor.

Take Augmentin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

To clear up your infection completely, take Augmentin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Augmentin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Augmentin.

Store Augmentin at or below 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Augmentin out of the reach of children and away from pets.

Active Ingredient: Amoxicillin/clavulanate potassium.

Do NOT use Augmentin if:

you are allergic to any ingredient in Augmentin or another penicillin antibiotic (eg, ampicillin)

you have a history of liver problems or yellowing of the eyes or skin caused by Augmentin

you have infectious mononucleosis (mono)

you are taking a tetracycline antibiotic (eg, doxycycline)

you have recently received or will be receiving live oral typhoid vaccine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Augmentin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of allergies, asthma, hay fever, or hives

if you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness) to a cephalosporin (eg, cephalexin) or another beta-lactam antibiotic (eg, imipenem)

if you have kidney problems or gonorrhea

if you have a history of liver problems or yellowing of the eyes or skin.

Some medicines may interact with Augmentin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin) because the risk of bleeding may be increased

Probenecid because it may increase the amount of Augmentin in your blood

Chloramphenicol, macrolide antibiotics (eg, erythromycin), sulfonamides (eg, sulfamethoxazole), or tetracycline antibiotics (eg, doxycycline) because they may decrease Augmentin's effectiveness

Methotrexate because the risk of its side effects may be increased by Augmentin

Live oral typhoid vaccine or hormonal birth control (eg, birth control pills) because their effectiveness may be decreased by Augmentin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Augmentin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Augmentin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Augmentin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Augmentin only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use Augmentin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Augmentin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Augmentin. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Brown, yellow, or gray tooth discoloration has occurred rarely in some patients taking Augmentin. It occurred most often in children. The discoloration was reduced or removed by brushing or dental cleaning in most cases. Contact your doctor if you experience this effect.

Diabetes patients - Augmentin may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.

Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed if you use Augmentin for a long period of time. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Augmentin with caution in the elderly; they may be more sensitive to its effects, especially patients with kidney problems.

Use Augmentin with extreme caution in children younger than 10 years old who have diarrhea or an infection of the stomach or bowel.

Augmentin should not be used in children who weigh less than 88 lbs (40 kg); safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Augmentin while you are pregnant. Augmentin is found in breast milk. If you are or will be breast-feeding while you use Augmentin, check with your doctor. Discuss any possible risks to your baby.



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Youke Hotel

Отель Youke расположен на знаменитой улице Чуньси-роуд в городе Чэнду. К услугам гостей кафетерий и бесплатный WiFi. В собственных ванных комнатах номеров приготовлены бесплатные туалетно-косметические принадлежности. Отель Youke находится в …

Отель Youke расположен на знаменитой улице Чуньси-роуд в городе Чэнду. К услугам гостей кафетерий и бесплатный WiFi. В собственных ванных комнатах номеров приготовлены бесплатные туалетно-косметические принадлежности.

Отель Youke находится в 10 минутах езды от аллеи Куанжай и в 20 минутах езды от старинной улицы Джинли и храма Вуху. До Северного жезнодорожного вокзала Чэнду 15 минут езды, а до Восточного железнодорожного вокзала - 20 минут езды. Поездка до международного аэропорта Чэнду Шуанлю займет 30 минут.

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Buy Other - Tebesium (Brand Name Isoniazid) Online - Order - Purchase Other - Tebesium (Brand Name I

Isoniazid is used for treating or preventing tuberculosis (TB). If you are using Isoniazid to treat TB, it should always be used along with another medicine. Isoniazid is an antibacterial. It works by killing TB organisms. soniazid also has an antidepressant effect, and it was one of the first antidepressants discovered. Isoniazid can also be used in the treatment of a BCG-oma.

Use Isoniazid as directed by your doctor.

Take each dose with a full glass (8 ounces) of water.

Take Isoniazid on an empty stomach 1 hour before or 2 hours after meals. If nausea occurs, ask your doctor if you can take Isoniazid with food.

Take all of the Isoniazid that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.

It is important to take Isoniazid regularly to get the most benefit.

Your doctor may also want you to take a supplemental vitamin B6 (pyridoxine) tablet daily during treatment to prevent numbness and tingling caused by low levels of this vitamin.

Your doctor may want you to have blood tests or other medical evaluations during treatment with Tebesium to monitor progress and side effects.

Continue to use Isoniazid even if you feel well. Do not miss any dose.

If you miss a dose of Isoniazid, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Isoniazid.

Store Isoniazid between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Isoniazid out of the reach of children and away from pets.

Do NOT use Isoniazid if:

you are allergic to any ingredient in Isoniazid or have had severe side effects from isoniazid, such as drug fever, chills, or arthritis

you have severe liver damage, active liver disease, or liver damage from previous use of Isoniazid

you have a history of hepatitis caused by any medicine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Isoniazid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diabetes, kidney problems, nerve problems (eg, neuropathy) or risk of nerve problems, HIV, or a history of liver problems

if you have a history of alcohol or other substance abuse, have unsanitary injectable drug habits, or drink alcohol daily

if you are older than 35 years old, you have recently given birth, or you have previously taken Isoniazid.

Some medicines may interact with Isoniazid. Tell your health care provider if you are taking any other medicines, especially any of the following:

Acetaminophen, anticoagulants (eg, warfarin), carbamazepine, hydantoins (eg, phenytoin), rifampin, theophylline, or valproic acid because the risk of their side effects may be increased by Isoniazid

Ketoconazole because its effectiveness may be decreased by Isoniazid.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Isoniazid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Check with your doctor before drinking alcohol while using Isoniazid. Alcohol may increase the risk of liver problems. If you have a history of alcohol abuse, you may also be at increased risk of developing nerve problems from Isoniazid. Notify your doctor if you notice any unusual tingling or numbness in your hands or feet.

If you have a history of diabetes, alcohol abuse, or poor nutrition, your doctor may recommend that you also take vitamin B 6 while you are taking Isoniazid. This may help to decrease your risk of nerve problems. Discuss any questions with your doctor.

Do not eat foods high in tyramine while you use Isoniazid. Eating foods high in tyramine (eg, aged cheeses, red wines, beer, certain meats and sausages, liver, sour cream, soy sauce, raisins, bananas, avocados) while you use Isoniazid may cause severe high blood pressure. Seek medical attention at once if symptoms of severe high blood pressure occur. These may include severe headache, fast or irregular heartbeat, sore or stiff neck, nausea, vomiting, sweating, enlarged pupils, or sensitivity to light.

Do not eat foods high in histamine while you use Isoniazid. Eating foods high in histamine (eg, skipjack, tuna, tropical fish) while you use Isoniazid may cause low blood pressure, irregular heartbeat, headache, sweating, or flushing. Contact your doctor at once if any of these symptoms occur.

Ask your health care provider for a complete list of all foods you should avoid while you are using Isoniazid.

Isoniazid only works against TB bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use Isoniazid for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Diabetes patients - Isoniazid may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. You may also be at increased risk of developing nerve problems from Isoniazid. Contact your doctor if you notice any unusual tingling in your hands or feet.

Lab tests, including liver function and eye exams, may be performed while you use Isoniazid. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Isoniazid with caution in black and Hispanic women; they may have a greater risk of severe liver problems from Isoniazid.

Use Isoniazid with caution in patients older 35 years; they may have a greater risk of severe liver problems from Isoniazid.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Isoniazid while you are pregnant. Isoniazid is found in breast milk. If you are or will be breast-feeding while you use Isoniazid, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Mild stomach upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; chills or fever; dark urine; general feeling of discomfort; increased thirst or urination; joint pain or swelling; loss of appetite; memory problems; mental or mood changes; nausea; seizures; stomach pain or tenderness; symptoms of low vitamin B 6 levels (eg, confusion, cracks in the corners of the mouth, irritability, mouth redness or soreness, scaly rash); tingling or numbness in the hands or feet; unusual bruising or bleeding; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Glucophage Xr Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Gluphage Xr

Glucophage XR

GENERIC NAME(S): METFORMIN HCL

Warnings

Metformin can rarely cause a serious (sometimes fatal) condition called lactic acidosis. Stop taking metformin and get medical help right away if you develop any of the following symptoms of lactic acidosis: unusual tiredness, dizziness. severe drowsiness, chills, blue/cold skin. muscle pain. fast/difficult breathing, slow/irregular heartbeat. stomach pain with nausea. vomiting. or diarrhea .

Lactic acidosis is more likely to occur in patients who have certain medical conditions, including kidney or liver disease, recent surgery, a serious infection, conditions that may cause a low level of oxygen in the blood or poor circulation (such as congestive heart failure. recent heart attack. recent stroke ), heavy alcohol use, a severe loss of body fluids (dehydration ), or X-ray or scanning procedures that require an injectable iodinated contrast drug. Tell your doctor right away if any of these conditions occur or if you notice a big change in your overall health. You may need to stop taking this medication temporarily. The elderly are also at higher risk, especially those older than 80 years who have not had kidney tests. (See also Side Effects and Precautions sections.)

Uses

Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach /intestines absorb.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

Metformin may be used with lifestyle changes such as diet and exercise to prevent diabetes in people who are at high risk for becoming diabetic. It is also used in women with a certain disease of the ovaries (polycystic ovarian syndrome ). Metformin may make menstrual cycles more regular and increase fertility .

How to use Glucophage XR

Read the Patient Information Leaflet if available from your pharmacist before you start taking metformin and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once daily with the evening meal. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.

Do not crush or chew this medication. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

Take this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day.

If you are already taking another anti-diabetic drug (such as chlorpropamide ), follow your doctor's directions carefully for stopping/continuing the old drug and starting metformin.

Check your blood sugar regularly as directed by your doctor. Keep track of the results, and share them with your doctor. Tell your doctor if your blood sugar measurements are too high or too low. Your dosage/treatment may need to be changed.

Side Effects

Nausea, vomiting, stomach upset, diarrhea, weakness. or a metallic taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away. Stomach symptoms that occur after the first days of your treatment may be signs of lactic acidosis.

An empty tablet shell may appear in your stool. This effect is harmless because your body has already absorbed the medication.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Metformin does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if this drug is prescribed with other anti-diabetic medications. Talk with your doctor or pharmacist about whether the dose of your other diabetic medication(s) needs to be lowered.

Symptoms of low blood sugar include sudden sweating. shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor about the reaction right away. Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise. or do not consume enough calories from food. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.

Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your doctor right away. Your doctor may need to adjust your diabetes medication(s).

Stop taking this medication and tell your doctor right away if this very serious side effect occurs: lactic acidosis (see Warning section).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

See also Warning section.

Before taking this medication, tell your doctor or pharmacist if you are allergic to metformin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: severe breathing problems (such as obstructive lung disease, severe asthma), blood problems (such as anemia, vitamin B12 deficiency), kidney disease, liver disease.

Before having surgery or any X-ray/scanning procedure using injectable iodinated contrast material, tell your doctor that you are taking this medication. You will need to temporarily stop this medication before the time of your surgery/procedure. Consult your doctor for further instructions.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

Limit alcohol while using this medication because it can increase your risk of lactic acidosis and developing low blood sugar.

High fever, "water pills" (diuretics such as hydrochlorothiazide), too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lactic acidosis. Stop taking this medication and tell your doctor right away if you have prolonged diarrhea or vomiting. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.

It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Consult your doctor because increased stress may require a change in your treatment plan, medications, or blood sugar testing.

Older adults may be a greater risk for side effects such as low blood sugar or lactic acidosis.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Your doctor may direct you to use insulin instead of this product during your pregnancy. Follow your doctor's instructions carefully.

Metformin can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Consult your doctor or pharmacist about the use of reliable birth control while using this medication.

Metformin passes into breast milk in small amounts. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Beta-blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are unaffected by these drugs.

Many drugs can affect your blood sugar levels, making it more difficult to control your blood sugar. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor about the results and of any symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your anti-diabetic medication, exercise program, or diet.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Overdose can cause lactic acidosis. Symptoms of overdose may include: severe drowsiness, severe nausea/vomiting/diarrhea, rapid breathing, slow/irregular heartbeat.

Notes

Do not share this medication with others.

You should attend a diabetes education program to learn more about diabetes and all the important aspects of its treatment, including meals/diet, exercise, personal hygiene, medications, and getting regular eye/foot/medical exams.

Keep all medical appointments. Laboratory and/or medical tests (such as liver/kidney function tests, blood glucose, hemoglobin A1c, complete blood counts) should be performed periodically to check for side effects and monitor your response to treatment. Check your blood sugar levels regularly as directed.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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You can wear dark glasses to help with the light sensitivity. A special dye is added to solid foods and liquids which the patient swallows. Consult your doctor before breast-feeding.

Contact your eye doctor if these problems occur. Give your infant a cool object to chew on, such as a firm rubber teething ring or a cold apple. Bacterial infections are most often the result a: Blockage from salivary duct stones.

Eltz, Stephanie Slon, and Nissi Wang. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. This information is not individual medical advice and does not substitute for the advice of your health care professional.

Specimen collection and handling fordiagnosis of infectious diseases. Mindful of these discussions, a panel of physicians and journalists offered pointers to those on the front lines during the joint meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy and the Infectious Diseases Society of America, held Oct.

Do not double the dose to catch up.

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Not applicable Canada Pioglitazone tablet 45 mg oral International Labs, Inc. It was selected for you based on your browsing activity. Novel approaches to pharmacoepidemiology study design and statistical analysis. MedicineNet does not provide medical advice, diagnosis or treatment. Funding National Institute of Neurological Disorders and Stroke. It is not feasible to conduct studies of microvascular outcomes in patients with impaired glucose tolerance because of the large sample and long study duration required.

Van Staa TP, Patel D, Gallagher AM, de Bruin ML. Get the Latest health and medical information delivered direct to your inbox!

However, bladder tumours have been reported in laboratory animals exposed to compounds with PPARОі activity, although these models are of uncertain relevance to human carcinogenesis, as considerable species specificity has been noted, with pioglitazone induced bladder cancer being documented in rats but not in mice.

If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking pioglitazone.

Pioglitazone may also be used for purposes not listed in this medication guide.

However, additional research is needed to elucidate the mechanisms by which a subset of pioglitazone PPAR agonists may increase the risk of bladder cancer, and specifically to determine if risk is indeed correlated with increased urinary crystals in humans, and if so to determine the basis of the crystal formation.

Thus, if a specific antidiabetic agent is discontinued, it would not be surprising for blood glucose levels to rise at some point after the medication is stopped.

Crude incidences of bladder cancer in pioglitazone users and nonusers were 89. Jacob A Udell, Matthew A Cavender, Deepak L Bhatt, Saurav Chatterjee, Michael E Farkouh, Benjamin M Scirica. The units are indicated along with the values. Keep this medication in the container it came in, tightly closed, and out of reach of children. The use of statins in people at risk of developing diabetes mellitus: Evidence and guidance for clinical practice.

Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. How to reduce Creatinine New treatment for high creatinine.



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Transcript

If you have some or all of the following symptoms you may have something called serotonin syndrome. The symptoms include: feeling confused, feeling restless, sweating, shaking, shivering, hallucinations (strange visions or sounds), sudden jerks of the muscles or a fast heartbeat. If you feel like this contact your doctor. Acute glaucoma. If your eyes become painful and you develop blurred vision, contact your doctor.

A widespread rash with blisters and skin peeling on much of the body surface (toxic epidermal necrolysis)

Liver problems that make the skin or whites of the eyes go yellow

Syndrome of inappropriate antidiuretic hormone production (SIADH) which is a condition in which the body develops an excess of water and a decrease in sodium (salt) concentration, as a result of improper chemical signals. Patients with SIADH may become severely ill or may have no symptoms at all

Frequency unknown Some people have had thoughts of harming or killing themselves while taking Seroxat or soon after stopping treatment (see section 2, What you need to know before you take Seroxat).

A widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome)

Fluid or water retention (which may cause swelling of the arms or legs)

263 LEAFLET Seroxat 20150216

Information for other strength of Seroxat also may be present in this leaflet. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.

? If you answer YES to any of these questions, and you have not already discussed them with your doctor, go back to your doctor and ask what to do about taking Seroxat.

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Children and adolescents under 18

Increases in the level of cholesterol in the blood

Reporting of side effects

Lack of appetite

Not sleeping well (insomnia) or feeling sleepy

Abnormal dreams (including nightmares)

Feeling dizzy or shaky (tremors)

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.

Difficulty in concentrating

What is in this leaflet: 1 2

What Seroxat is and what it is used for What you need to know before you take Seroxat

How to take Seroxat

Possible side effects

How to store Seroxat

How to store Seroxat

Contents of the pack and other information

Keep your tablets in the pack with this leaflet.

What Seroxat is and what it is used for

Do not store your tablets above 30°C.

Feeling unusually weak

KEEP OUT OF THE SIGHT AND REACH OF CHILDREN.

Do not take your tablets after the expiry date shown on the pack.

Yawning, dry mouth

Diarrhoea or constipation

If you are using half tablets, be careful to keep them safely in the pack.

Never give these tablets to others, even if they have similar symptoms to yours.

Finish all your tablets as the doctor tells you to.

If the medicine becomes discoloured or shows any other signs of deterioration, you should seek the advice of your pharmacist who will tell you what to do.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Seroxat is a treatment for adults with depression and/or anxiety disorders. The anxiety disorders that Seroxat is used to treat are: obsessive compulsive disorder (repetitive, obsessive thoughts with uncontrollable behaviour), panic disorder (panic attacks, including those caused by agoraphobia, which is a fear of open spaces), social anxiety disorder (fear or avoidance of social situations), post traumatic stress disorder (anxiety caused by a traumatic event) and generalised anxiety disorder (generally feeling very anxious or nervous). Seroxat is one of a group of medicines called SSRIs (selective serotonin reuptake inhibitors). Everyone has a substance called serotonin in their brain. People who are depressed or anxious have lower levels of serotonin than others. It is not fully understood how Seroxat and other SSRIs work but they may help by increasing the level of serotonin in the brain. Treating depression or anxiety disorders properly is important to help you get better.

Contents of the pack and other information

A brief increase in blood pressure, or a brief decrease that may make you feel dizzy or faint when you stand up suddenly

A faster than normal heartbeat

Lack of movement, stiffness, shaking or abnormal movements in the mouth and tongue

What Seroxat contains

Having hallucinations (strange visions or sounds)

An inability to urinate (urinary retention) or an uncontrollable, involuntary passing of urine (urinary incontinence).

The active ingredient in Seroxat film-coated tablets is paroxetine (as paroxetine hydrochloride hemihydrate). Each tablet contains 20mg of the active ingredient, paroxetine (as the hydrochloride). The inactive ingredients are calcium hydrogen phosphate, magnesium stearate, sodium starch glycollate, hydroxypropylmethylcellulose, titanium dioxide (E171), polyethylene glycol and polysorbate 80.

Rare side effects, likely to affect up to 1 in every 1,000 people:

What Seroxat looks like and contents of the pack

Abnormal production of breast milk in men and women

A slow heartbeat

Effects on the liver showing up in blood tests of your liver function

Seroxat 20mg tablets are white, oval shaped, marked with “20” on one side and a break line on the other. Seroxat is available as blister packs of 14 and 28 tablets.

Feeling anxious Irresistible urge to move the legs (Restless Legs Syndrome)

Pain in the joints or muscles

? Increase in a hormone called prolactin in the blood. Very rare side effects, likely to affect up to 1 in every 10,000 people: ?

Skin rash, which may blister, and looks like small targets (central dark spots surrounded by a paler area, with a dark ring around the edge) called erythema multiforme

Are you under 18 years old (see Children and adolescents under 18, inside this leaflet)?

Low blood platelet count.

Painful erection of the penis that won’t go away

Common side effects, likely to affect up to 1 in 10 people:

Are you pregnant or planning to get pregnant (see Pregnancy, breast-feeding and fertility, inside this leaflet)?

Some patients have developed buzzing, hissing, whistling, ringing or other persistent noise in the ears (tinnitus) when they take Seroxat. An increased risk of bone fractures has been observed in patients taking this type of medicine.

Feeling detached from yourself (depersonalisation)

Do you have glaucoma (pressure in the eye)?

Change in sex drive or sexual function. For example, lack of orgasm and, in men, abnormal erection and ejaculation.

Are you on a low sodium diet?

If you have any further questions, ask your doctor or pharmacist.

Overactive behaviour or thoughts (mania)

Sensitivity to sunlight

Feeling sick (nausea). Taking your medicine in the morning with food will reduce the chance of this happening.

Do you have diabetes?

(paroxetine) Your medicine is marketed using the above names but will be referred to as Seroxat throughout the following patient information leaflet.

Keep this leaflet. You may need to read it again.

SEROXAT 20mg TABLETS PAROXETINE 20mg TABLETS

Do you have a history of bleeding disorders, or are you taking other medicines that may increase the risk of bleeding (these include medicines used to thin the blood, such as warfarin, antipsychotics such as perphenazine or clozapine, tricyclic antidepressants, medicines used for pain and inflammation called non-steroidal anti-inflammatory drugs or NSAIDs, such as acetylsalicylic acid, ibuprofen, celecoxib, etodolac, diclofenac, meloxicam)?

Other possible side effects during treatment Very common side effects, likely to affect more than 1 in 10 people:

? Sweating. Uncommon side effects, likely to affect up to 1 in every 100 people:

PACKAGE LEAFLET: INFORMATION FOR THE PATIENT

Manufactured by: This product is manufactured by S. C Europharm S. A. 2 Panselelor St. Brasov, Condado de Brasov 500419, Romania. Product Licence holder Procured from within the EU and repackaged by the PL holder: Chemilines Ltd, Chemilines House, Alperton Lane, Wembley, HA0 1DX. POM

PL No. 08747/0263

Leaflet revision date: 16 February 2015 Seroxat is a trademark of GlaxoSmithKline group of companies. 263 LEAFLET Seroxat 20150216

What you need to know before you take Seroxat

Do not take Seroxat ?

If you are taking medicines called monoamine oxidase inhibitors (MAOIs, including moclobemide and methylthioninium chloride (methylene blue)) or have taken them at any time within the last two weeks. Your doctor will advise you how you should begin taking Seroxat once you have stopped taking the MAOI.

If you are taking an anti-psychotic called thioridazine or an anti-psychotic called pimozide.

If you are allergic to paroxetine or any of the other ingredients of this medicine (listed in section 6). ? If any of these apply to you, tell your doctor without taking Seroxat Warnings and precautions Talk to your doctor or pharmacist before taking Seroxat ?

Are you taking any other medicines (see Taking other medicines and Seroxat, inside this leaflet)?

Are you taking tamoxifen to treat breast cancer or fertility problems? Seroxat may make tamoxifen less effective, so your doctor may recommend you take another antidepressant.

Do you have kidney, liver or heart trouble?

Do you have epilepsy or have a history of fits or seizures?

Have you ever had episodes of mania (overactive behaviour or thoughts)?

Are you having electro-convulsive therapy (ECT)?

Seroxat should not be used for children and adolescents under 18 years. Also, patients under 18 have an increased risk of side effects such as suicide attempt, suicidal thoughts and hostility (predominantly aggression, oppositional behaviour and anger) when they take Seroxat. If your doctor has prescribed Seroxat for you (or your child) and you want to discuss this, please go back to your doctor. You should inform your doctor if any of the symptoms listed above develop or worsen when you (or your child) are taking Seroxat. Also, the long-term safety effects, concerning growth, maturation and cognitive and behavioural development, of Seroxat in this age group have not yet been demonstrated. In studies of Seroxat in under 18s, common side effects that affected less than 1 in 10 children/adolescents were: an increase in suicidal thoughts and suicide attempts, deliberately harming themselves, being hostile, aggressive or unfriendly, lack of appetite, shaking, abnormal sweating, hyperactivity (having too much energy), agitation, changing emotions (including crying and changes in mood) and unusual bruising or bleeding (such as nose bleeds). These studies also showed that the same symptoms affected children and adolescents taking sugar pills (placebo) instead of Seroxat, although these were seen less often. Some patients in these studies of under 18s had withdrawal effects when they stopped taking Seroxat. These effects were mostly similar to those seen in adults after stopping Seroxat (see section 3, How to take Seroxat, inside this leaflet). In addition, patients under 18 also commonly (affecting less than 1 in 10) experienced stomach ache, feeling nervous and changing emotions (including crying, changes in mood, trying to hurt themselves, thoughts of suicide and attempting suicide). Thoughts of suicide and worsening of your depression or anxiety disorder If you are depressed and/or have anxiety disorders you can sometimes have thoughts of harming or killing yourself. These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer. You may be more likely to think like this: ?

If you have previously had thoughts about killing or harming yourself.

If you are a young adult. Information from clinical trials has shown an increased risk of suicidal behaviour in adults aged less than 25 years with psychiatric conditions who were treated with an antidepressant. ? If you have thoughts of harming or killing yourself at any time, contact your doctor or go to a hospital straight away. You may find it helpful to tell a relative or close friend that you are depressed or have an anxiety disorder, and ask them to read this leaflet. You might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behaviour.

Important side effects seen with Seroxat

Pregnancy, breast-feeding and fertility

Some patients who take Seroxat develop something called akathisia, where they feel restless and feel like they can’t sit or stand still. Other patients develop something called serotonin syndrome, where they have some or all of the following symptoms: feeling confused, feeling restless, sweating, shaking, shivering, hallucinations (strange visions or sounds), sudden jerks of the muscles or a fast heartbeat. If you notice any of these symptoms, contact your doctor. For more information on these or other side effects of Seroxat, see section 4, Possible side effects, inside this leaflet. Other medicines and Seroxat

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. In babies whose mothers took Seroxat during the first few months of pregnancy, there have been some reports showing an increased risk of birth defects, in particular those affecting the heart. In the general population, about 1 in 100 babies are born with a heart defect. This increased to up to 2 in 100 babies in mothers who took Seroxat. You and your doctor may decide that it is better for you to change to another treatment or to gradually stop taking Seroxat while you are pregnant. However, depending on your circumstances, your doctor may suggest that it is better for you to keep taking Seroxat.

Some medicines can affect the way Seroxat works, or make it more likely that you’ll have side effects. Seroxat can also affect the way some other medicines work. These include: ?

Medicines called monoamine oxidase inhibitors (MAOIs, including moclobemide and methylthioninium chloride (methylene blue) ) – see Do not take Seroxat, in this section Thioridazine or pimozide, which are anti-psychotics – see Do not take Seroxat, in this section Aspirin (acetylsalicylic acid), ibuprofen or other medicines called NSAIDs (non-steroidal anti-inflammatory drugs) like celecoxib, etodolac, diclofenac and meloxicam, used for pain and inflammation

Tramadol and pethidine, painkillers

Medicines called triptans, such as sumatriptan, used to treat migraine

Other antidepressants including other SSRIs, tryptophan and tricyclic antidepressants like clomipramine, nortriptyline and desipramine A dietary supplement called tryptophan Mivacurium and suxamethonium (used in anaesthesia) Medicines such as lithium, risperidone, perphenazine, clozapine (called anti-psychotics) used to treat some psychiatric conditions

Fentanyl, used in anaesthesia or to treat chronic pain

A combination of fosamprenavir and ritonavir, which is used to treat Human Immunodeficiency Virus (HIV) infection

St John’s Wort, a herbal remedy for depression

Phenobarbital, phenytoin, sodium valproate or carbamazepine, used to treat fits or epilepsy

Atomoxetine which is used to treat attention deficit hyperactivity disorder (ADHD)

Procyclidine, used to relieve tremor, especially in Parkinson’s Disease

Make sure your midwife or doctor knows you’re taking Seroxat. When taken during pregnancy, particularly late pregnancy, medicines like Seroxat may increase the risk of a serious condition in babies, called persistent pulmonary hypertension of the newborn (PPHN). In PPHN, the blood pressure in the blood vessels between the baby’s heart and the lungs is too high. If you take Seroxat during the last 3 months of pregnancy, your newborn baby might also have other conditions, which usually begin during the first 24 hours after birth. Symptoms include: ?

trouble with breathing

a blueish skin or being too hot or cold

Obsessive Compulsive Disorder (obsessions and compulsions



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Betnovate (Betodermin)

Betnovate is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid (cortisone-like medicine or steroid).

Use Betnovate as directed by your doctor.

Betnovate is for use on the skin only. Do not get it in your eyes.

Wash your hands with soap and water before and after using this medicine.

Apply a thin layer of this medicine to the affected area of the skin. Rub it in gently.

Do not use cosmetics or other skin care products on the treated areas.

Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.

If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.

If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems.

If you miss a dose of Betnovate, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For redness, itching, and swelling of the skin:

Adults: Apply to the affected area of the skin one to three times per day.

Children: Use and dose must be determined by your doctor.

Ask your health care provider any questions you may have about how to use Betnovate.

Store Betnovate at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Betnovate out of the reach of children and away from pets.

Active Ingredient: Betamethasone.

Do NOT use Betnovate if:

you are allergic to any ingredient in Betnovate

you are taking mifepristone

you have a systemic fungal infection

you are scheduled to have a smallpox vaccine

you have a certain bleeding disorder (idiopathic thrombocytopenic purpura).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Betnovate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of bleeding problems, heart problems (eg, congestive heart failure [CHF]), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, any mental or mood problems, or low blood potassium levels

if you have or have recently had a bacterial, fungal, malarial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; shingles; or a head or brain injury

if you have HIV infection or tuberculosis (TB), or if you have ever had a positive TB skin test

if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, infection, unexplained diarrhea, diverticulitis, ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus

if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)

if you have had any recent vaccinations (eg, smallpox)

if you have a history of joint surgery or any joint problems (eg, fracture, infection).

Some medicines may interact with Betnovate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aprepitant, clarithromycin, cyclosporine, diltiazem, erythromycin, itraconazole, ketoconazole, or troleandomycin because side effects, such as adrenal gland or nervous system problems (eg, seizures), may occur

Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), lithium, or rifampin because they may decrease Betnovate's effectiveness

Aspirin, live vaccines, mifepristone, or ritodrine because the risk of their side effects may be increased by Betnovate.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Betnovate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Betnovate may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

Tell your doctor or dentist that you take Betnovate before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Betnovate may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If you use Betnovate for an extended period of time, your body may not produce enough natural steroids for up to several months after you stop using it. Severe symptoms may occur if you experience injury, surgery, infection, or loss of blood electrolytes. Contact your doctor immediately if you experience any of these events. You may need to begin taking additional corticosteroids.

If you have had Betnovate injected into a joint and you experience increased pain along with swelling, decreased joint movement, fever, and general feeling of being unwell, contact your doctor.

Talk with your doctor before you receive any vaccine while you are using Betnovate.

Lab tests, including adrenal function tests and blood pressure monitoring, may be performed while you use Betnovate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Betnovate may have benzyl alcohol in it. Do not use it in newborns or infants. It may cause serious and sometimes fatal nervous system problems and other side effects.

Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Betnovate.

Betnovate should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Betnovate while you are pregnant. Betnovate is found in breast milk. If you are or will be breast-feeding while you use Betnovate, check with your doctor. Discuss any possible risks to your baby.

If you suddenly stop taking Betnovate, you may have withdrawal symptoms, These may include unbalanced hormones (in both men and women).

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; clumsiness; dizziness; facial flushing; general body discomfort; headache; increased appetite; increased sweating; lightheadedness; nausea; nervousness; sleeplessness; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual periods; changes in skin color; chest pain; easy bruising or bleeding; irregular heartbeat; mental or mood changes (eg, depression); muscle pain, wasting, or weakness; seizures; severe nausea or vomiting; sudden severe dizziness or headache; swelling of feet or legs; symptoms of infection (eg, chills, fever, sore throat); tendon or bone pain; thinning of the skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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SureShot Wireless Remote is a programmable, flexible and inexpensive way to remotely control up to eight functions or pieces of equipment.

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DRUG DESCRIPTION

Meperidine hydrochloride is ethyl 1-methyl-4-phenylisonipecotate hydrochloride, a white crystalline substance with a melting point of 186°C to 189°C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling.

Demerol ™ injection is supplied as: Carpuject™ Single-use cartridges with luer lock at concentrations of 25 mg/mL, 50 mg/mL, 75 mg/mL, and 100 mg/mL; Uni-Amp™ unit dose pak-ampuls at concentrations of 25 mg/0.5 mL, 50 mg/mL, 75 mg/1.5 mL, 100 mg/2 mL, and 100 mg/mL; and Multiple-use vials at concentrations of 50 mg/mL (1500 mg/30 mL) and 100 mg/mL (2000 mg/20 mL), which contain metacresol 0.1% as a preservative.

The pH of Demerol™ solutions is adjusted between 3.5 and 6 with sodium hydroxide or hydrochloric acid.

Demerol™, brand of meperidine hydrochloride, 5 percent solution has a specific gravity of 1.0086 at 20°C and 10 percent solution, a specific gravity of 1.0165 at 20°C.

What are the possible side effects of meperidine (Demerol HCl)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

weak or shallow breathing, slow heartbeat;

severe drowsiness, feeling like you might pass out;

seizure (convulsions);

cold, clammy skin;

muscle movements you cannot control;

confusion, mood changes;

severe weakness or dizziness; or

agitation, hallucinations, fever, fast heart rate.

What are the precautions when taking meperidine (Demerol)?

Before taking meperidine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before taking this medication, tell your doctor or pharmacist your medical history, especially of: abdominal problems (e. g. gallbladder disease, pancreatitis), adrenal gland problem (e. g. Addison's disease, pheochromocytoma), large blood loss (e. g. recent blood donation, stomach/intestinal bleeding), brain disorders (e. g. seizures, head injury, tumor, increased intracranial pressure), heart problems (e. g. irregular heartbeat, low blood pressure), kidney disease, liver disease, breathing problems (e. g. asthma.

Last reviewed on RxList: 1/5/2016 This monograph has been modified to include the generic and brand name in many instances.



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Pantecta Control 20 Mg Gastro-Resistant Tablets, Pantecta

PANTECTA Control 20 mg gastro-resistant tablets

PANTECTA Control contains the active substance pantoprazole, which blocks the ‘pump’ that produces stomach acid. Hence it reduces the amount of acid in your stomach.

PANTECTA Control is used for the short-term treatment of reflux symptoms (for example heartburn, acid regurgitation) in adults. Reflux is the backflow of acid from the stomach into the gullet (“foodpipe”), which may become inflamed and painful. This may cause you symptoms such as a painful burning sensation in the chest rising up to the throat (heartburn) and a sour taste in the mouth (acid regurgitation).

You may experience relief from your acid reflux and heartburn symptoms after just one day of treatment with PANTECTA Control, but this medicine is not meant to bring immediate relief. It may be necessary to take the tablets for 2-3 consecutive days to relieve the symptoms.

Do not take PANTECTA Control:

if you are allergic (hypersensitive) to pantoprazole, to soya or to any of the other ingredients of PANTECTA Control (listed insection 6 ‘What PANTECTA Control contains’).

if you are taking a medicine containing atazanavir (for the treatment of HIV-infection)

if you are under 18 years of age

if you are pregnant or breast-feeding.

Take special care with PANTECTA Control Talk to your doctor first if:

you have been treated for heartburn or indigestion continuously for 4 or more weeks

you are over 55 years old and taking non-prescription indigestion treatment on a daily basis

you are over 55 years old with new or recently changed symptoms

you have previously had a gastric ulcer or stomach surgery

you have liver problems or jaundice (yellowing of skin or eyes)

you regularly see your doctor for serious complaints or conditions

you are due to have an endoscopy or a breath test called a C-urea test.

Tell your doctor immediately . before or after taking this medicine, if you notice any of the following symptoms, which could be a sign of another, more serious, disease:

an unintentional loss of weight (not related to a diet or an exercise programme)

vomiting, particularly if repeated

vomiting blood; this may appear as dark coffee grounds in your vomit

you notice blood in your stools; which may be black or tarry in appearance

difficulty in swallowing or pain when swallowing

you look pale and feel weak (anaemia)

chest pain

stomach pain

severe and/or persistent diarrhoea, because PANTECTA Control has been associated with a small increase in infectious diarrhoea. Your doctor may decide that you need some tests.

If you are due to have a blood test, tell your doctor that you are taking this medicine.

You may experience relief from your acid reflux and heartburn symptoms after just one day of treatment with PANTECTA Control, but this medicine is not meant to bring immediate relief. You should not take it as a preventive measure.

If you have been suffering from repetitive heartburn or indigestion symptoms for some time, remember to see your doctor regularly.

Using other medicines PANTECTA Control may stop certain other medicines from working properly. Tell yourdoctor or pharmacist if you are using anymedicines containing one of the following active substances:

ketoconazole (used for fungal infections).

warfarin and phenprocoumon(used to thin blood and prevent clots). You may need further blood tests

atazanavir (used to treat HIV-infection). You must not use PANTECTA Control if you are taking atazanavir.

Do not take PANTECTA Control with other medicines which limit the amount of acid produced in your stomach, such as another proton pump inhibitor (omeprazole, lansoprazole or rabeprazole) or an H2 antagonist (e. g. ranitidine, famotidine). However, you may take PANTECTA Control with antacids (e. g. magaldrate, alginic acid, sodium bicarbonate, aluminium hydroxide, magnesium carbonate, or combinations thereof), if needed.

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. This alsoincludes herbal or homeopathic remedies.

Using PANTECTA Control with food and drink The tablets should be swallowed whole with liquid before a meal.

Pregnancy and breast-feeding Do not take PANTECTA Control if you are pregnant, think you may be pregnant, or are breast-feeding. Ask your doctor or pharmacist for advice before taking any medicine.

Driving and using machines If you experience side effects like dizziness or disturbed vision, you should not drive or operate machines.

Important information about some of the ingredients of PANTECTA Control PANTECTA Control contains soya lecithin. If you are allergic to peanut or soya, do not use this medicine.

Always take PANTECTA Control exactly as described in this leaflet. You should check with your doctor orpharmacist if you are not sure.

Take one tablet a day. Do not exceed this recommended dose of 20 mg pantoprazole daily.

You should take this medicine for at least 2-3 consecutive days. Stop taking PANTECTA Control when you are completely symptom-free. You may experience relief from your acid reflux and heartburn symptoms after just one day of treatment with PANTECTA Control, but this medicine is not meant to bring immediate relief.

If you have no symptom-relief after taking this medicine for 2 weeks continuously, consult your doctor. Do not take PANTECTA Control tablets for more than 4 weeks without consulting your doctor.

Take the tablet before a meal, at the same time every day. You should swallow the tablet whole with some water. Do not chew or break the tablet.

Children and adolescents PANTECTA Control should not be used by children and young people under 18 years of age.

If you take more PANTECTA Control than you should Tell your doctor or pharmacist straight away. If possible take your medicine and this leaflet with you. There are no known symptoms of overdose.

If you forget to take PANTECTA Control Do not take a double dose to make up for the forgotten dose. Take your next, normal dose, the next day, at your usual time.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Like all medicines, PANTECTA Control can cause side effects, although not everybody gets them.

Tell your doctor immediately or contact the casualty department at your nearest hospital, if you get any of the following serious side effects . Stop taking this medicine straight away, but take this leaflet and/or the tablets with you.

Serious allergic reactions (rare) . Hypersensitivity reactions, so-called anaphylactic reactions, anaphylactic shock and angioedema. Typical symptoms are: swelling of the face, lips, mouth, tongue and/or throat, which may cause difficulty in swallowing or breathing, hives (nettle rash), severe dizziness with very fast heartbeat and heavy sweating.

Serious skin reactions (frequency not known) . rash with swelling, blistering or peeling of the skin, losing skin and bleeding around eyes, nose, mouth or genitals and rapid deterioration of your general health, or rash when exposed to the sun.

Other serious reactions (frequency not known) :yellowing of the skin and eyes (due to severe liver damage), or kidney problems such as painful urination and lower back pain with fever.

Side effects may occur with certain frequencies, which are defined as follows:

very common: affects more than 1 user in 10 common: affects 1 to 10 users in 100 uncommon: affects 1 to 10 users in 1,000 rare: affects 1 to 10 users in 10,000 very rare: affects less than 1 user in 10,000 not known: frequency cannot be estimated from the available data.

Uncommon side effects . headache; dizziness; diarrhoea; feeling sick, vomiting; bloating and flatulence (wind); constipation; dry mouth; bellyache and discomfort; skin rash or hives; itching; feeling weak, exhausted or generally unwell; sleep disorders; increase in liver enzymes in a blood test.

Rare side effects . disturbances in vision such as blurred vision; pain in the joints; muscle pains; weight changes; raised body temperature; swelling of the extremities; allergic reactions; depression; increased bilirubin and fat levels in blood (seen in blood tests).

Very rare side effects . disorientation; reduction in the number of blood platelets, which may cause you to bleed or bruise more than normal; reduction in the number of white blood cells, which may lead to more frequent infections.

Frequency not known :hallucination, confusion (especially in patients with a history of these symptoms); decreased level of sodium in blood.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

Keep out of the reach and sight of children.

Do not use PANTECTA Control after the expiry date, which isstated on the carton and the blister. The expiry date refers to the last day of that month.

Store in the original package in order to protect from moisture .

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.



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