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Topiramate because the risk of high ammonium levels, brain problems, or an unusual drop in body temperature may be increased

Acyclovir, cancer medicines, carbapenem antibiotics (eg, ertapenem, imipenem, meropenem), cholestyramine, hydantoins (eg, phenytoin), mefloquine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral contraceptives (eg, birth control pills), or rifampin because they may decrease Depakote's effectiveness

Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital), ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine because the risk of their side effects may be increased by Depakote.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Depakote may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Depakote may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Depakote with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Depakote; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Inflammation of the pancreas is a potentially life-threatening illness associated with Depakote. Symptoms include stomach pain, vomiting, or loss of appetite. Contact your doctor at once if any of these symptoms occur.

Patients who take Depakote may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Patients who have bipolar (manic-depressive) illness may also have an increased risk for suicidal thoughts or actions. Watch patients who take Depakote closely. Contact the doctor at once if new, worsened, or sudden symptoms, such as depressed mood; anxious, restless, irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Depakote may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.

Tell your doctor or dentist that you take Depakote before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Depakote may cause the results of some tests for urine ketones to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.

Depakote may increase the ammonia levels in your blood. Contact your doctor right away if you experience unexplained sluggishness and vomiting or mental changes.

Depakote may cause an unusual drop in body temperature (hypothermia). Symptoms may include confusion, lack of energy, loss of coordination, shivering, slow heartbeat, slow or shallow breathing, slurred speech, or unusual drowsiness. Contact your doctor right away if you have any of these symptoms.

Depakote may interfere with certain lab tests, including thyroid function. Be sure your doctor and lab personnel know you are taking Depakote

Lab tests, including complete blood cell counts, blood ammonia levels, and liver function, may be performed while you use Depakote. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Depakote with caution in the elderly; they may be more sensitive to its effects, especially drowsiness.

Depakote should be used with extreme caution in children younger than 10 years old; safety and effectiveness in these children have not been confirmed. Children younger 2 years may be at increased risk of serious liver problems.

Pregnancy and breast-feeding: Depakote has been shown to cause harm to the fetus. Use an effective form of birth control while you take Depakote. If you think you may be pregnant or if you wish to become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Depakote while you are pregnant. Depakote is found in breast milk. Do not breastfeed while you are taking Depakote.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Change in appetite; constipation; diarrhea; dizziness; drowsiness; hair loss; headache; indigestion; nausea; stomach cramps or pain; trouble sleeping; vomiting; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; change in menstrual period; changes in behavior; chest pain; confusion; dark, tarry, or bloody stools; dark urine; difficulty speaking; difficulty urinating or other urination problems; extreme tiredness; fast or irregular heartbeat; hallucinations; hearing loss; involuntary movements of the arms and legs; involuntary movements or chewing movements of the face, jaw, mouth, or tongue; joint pain; lack of energy; loss of appetite; loss of coordination; loss of seizure control; memory loss; new or worsening mental or mood changes (eg, aggressiveness, agitation, anxiety, depression, exaggerated feeling of well-being, hostility, impulsiveness, inability to sit still, irritability, panic attacks, restlessness); nosebleed; pounding in the chest; red, swollen, blistered, or peeling skin; severe or persistent nausea, vomiting, or stomach pain; shortness of breath; suicidal thoughts or actions; swelling of the arms or legs; symptoms of infection (eg, fever, chills, sore throat); tremor; unusual bleeding or bruising; unusual weakness; vision changes or blurred vision; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Depakote is used to treat various types of seizure disorders. It is sometimes used together with other seizure medications. It is also used to treat the manic phase of bipolar disorders (manic-depressive illness), and to prevent migraine headaches. Depakote affects chemicals in the body that may be involved in causing seizures.

Use Depakote as directed by your doctor.

Take Depakote by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Swallow Depakote whole. Do not break, crush, or chew before swallowing.

Drink plenty of water while you are taking Depakote. Your dose may need to be changed if you do not get enough fluids each day.

Do not stop taking Depakote suddenly, especially if you are taking Depakote to prevent seizures. Suddenly stopping Depakote may cause severe seizures to occur. If you need to stop Depakote, your doctor will gradually lower your dose.

Taking Depakote at the same time each day will help you remember to take it.

Continue to take Depakote even if you feel well. Do not miss any dose. Depakote works best when there is a constant level of it in your body.

If you miss a dose of Depakote, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Depakote.

Store Depakote between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Depakote out of the reach of children and away from pets.

Active Ingredient: Divalproex.

Do NOT use Depakote if:

you are allergic to any ingredient in Depakote

you have liver problems or a urea cycle disorder.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Depakote. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of alcohol abuse, liver problems, metabolic disease, blood disease, HIV infection, cytomegalovirus (CMV) infection, high blood levels of ammonia or glutamine, low body temperature, low levels of albumin, brain problems (eg, organic brain disease), mental retardation, inflammation of the pancreas, kidney problems, or low levels of white blood cells, or if you are scheduled for surgery

if you have a history of ornithine transcarbamylase deficiency or unexplained coma

if you have a family history of urea cycle disorders or unexplained infant deaths

if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or actions

if you take any other medicine for seizures.

Some medicines may interact with Depakote. Tell your health care provider if you are taking any other medicines, especially any of the following:

Benzodiazepines (eg, diazepam), carbamazepine, erythromycin, felbamate, fluoxetine, guanfacine, isoniazid, ketoconazole, risperidone, or salicylates (eg, aspirin) because the risk of serious side effects of Depakote, including changes in vision or other vision problems, clumsiness or unsteadiness, drowsiness, nausea, or vomiting, may be increased

Clonazepam because the risk of seizures may be increased

Topiramate because the risk of high ammonium levels, brain problems, or an unusual drop in body temperature may be increased

Acyclovir, cancer medicines, carbapenem antibiotics (eg, ertapenem, imipenem, meropenem), cholestyramine, hydantoins (eg, phenytoin), mefloquine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral contraceptives (eg, birth control pills), or rifampin because they may decrease Depakote's effectiveness

Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital), ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine because the risk of their side effects may be increased by Depakote.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Depakote may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Depakote may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Depakote with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Depakote; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Inflammation of the pancreas is a potentially life-threatening illness associated with Depakote. Symptoms include stomach pain, vomiting, or loss of appetite. Contact your doctor at once if any of these symptoms occur.

Patients who take Depakote may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Patients who have bipolar (manic-depressive) illness may also have an increased risk for suicidal thoughts or actions. Watch patients who take Depakote closely. Contact the doctor at once if new, worsened, or sudden symptoms, such as depressed mood; anxious, restless, irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Depakote may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.

Tell your doctor or dentist that you take Depakote before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Depakote may cause the results of some tests for urine ketones to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.

Depakote may increase the ammonia levels in your blood. Contact your doctor right away if you experience unexplained sluggishness and vomiting or mental changes.

Depakote may cause an unusual drop in body temperature (hypothermia). Symptoms may include confusion, lack of energy, loss of coordination, shivering, slow heartbeat, slow or shallow breathing, slurred speech, or unusual drowsiness. Contact your doctor right away if you have any of these symptoms.

Depakote may interfere with certain lab tests, including thyroid function. Be sure your doctor and lab personnel know you are taking Depakote

Lab tests, including complete blood cell counts, blood ammonia levels, and liver function, may be performed while you use Depakote. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Depakote with caution in the elderly; they may be more sensitive to its effects, especially drowsiness.

Depakote should be used with extreme caution in children younger than 10 years old; safety and effectiveness in these children have not been confirmed. Children younger 2 years may be at increased risk of serious liver problems.

Pregnancy and breast-feeding: Depakote has been shown to cause harm to the fetus. Use an effective form of birth control while you take Depakote. If you think you may be pregnant or if you wish to become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Depakote while you are pregnant. Depakote is found in breast milk. Do not breastfeed while you are taking Depakote.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Change in appetite; constipation; diarrhea; dizziness; drowsiness; hair loss; headache; indigestion; nausea; stomach cramps or pain; trouble sleeping; vomiting; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; change in menstrual period; changes in behavior; chest pain; confusion; dark, tarry, or bloody stools; dark urine; difficulty speaking; difficulty urinating or other urination problems; extreme tiredness; fast or irregular heartbeat; hallucinations; hearing loss; involuntary movements of the arms and legs; involuntary movements or chewing movements of the face, jaw, mouth, or tongue; joint pain; lack of energy; loss of appetite; loss of coordination; loss of seizure control; memory loss; new or worsening mental or mood changes (eg, aggressiveness, agitation, anxiety, depression, exaggerated feeling of well-being, hostility, impulsiveness, inability to sit still, irritability, panic attacks, restlessness); nosebleed; pounding in the chest; red, swollen, blistered, or peeling skin; severe or persistent nausea, vomiting, or stomach pain; shortness of breath; suicidal thoughts or actions; swelling of the arms or legs; symptoms of infection (eg, fever, chills, sore throat); tremor; unusual bleeding or bruising; unusual weakness; vision changes or blurred vision; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Depakote is used to treat various types of seizure disorders. It is sometimes used together with other seizure medications. It is also used to treat the manic phase of bipolar disorders (manic-depressive illness), and to prevent migraine headaches. Depakote affects chemicals in the body that may be involved in causing seizures.

Use Depakote as directed by your doctor.

Take Depakote by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Swallow Depakote whole. Do not break, crush, or chew before swallowing.

Drink plenty of water while you are taking Depakote. Your dose may need to be changed if you do not get enough fluids each day.

Do not stop taking Depakote suddenly, especially if you are taking Depakote to prevent seizures. Suddenly stopping Depakote may cause severe seizures to occur. If you need to stop Depakote, your doctor will gradually lower your dose.

Taking Depakote at the same time each day will help you remember to take it.

Continue to take Depakote even if you feel well. Do not miss any dose. Depakote works best when there is a constant level of it in your body.

If you miss a dose of Depakote, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Depakote.

Store Depakote between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Depakote out of the reach of children and away from pets.

Active Ingredient: Divalproex.

Do NOT use Depakote if:

you are allergic to any ingredient in Depakote

you have liver problems or a urea cycle disorder.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Depakote. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of alcohol abuse, liver problems, metabolic disease, blood disease, HIV infection, cytomegalovirus (CMV) infection, high blood levels of ammonia or glutamine, low body temperature, low levels of albumin, brain problems (eg, organic brain disease), mental retardation, inflammation of the pancreas, kidney problems, or low levels of white blood cells, or if you are scheduled for surgery

if you have a history of ornithine transcarbamylase deficiency or unexplained coma

if you have a family history of urea cycle disorders or unexplained infant deaths

if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or actions

if you take any other medicine for seizures.

Some medicines may interact with Depakote. Tell your health care provider if you are taking any other medicines, especially any of the following:

Benzodiazepines (eg, diazepam), carbamazepine, erythromycin, felbamate, fluoxetine, guanfacine, isoniazid, ketoconazole, risperidone, or salicylates (eg, aspirin) because the risk of serious side effects of Depakote, including changes in vision or other vision problems, clumsiness or unsteadiness, drowsiness, nausea, or vomiting, may be increased

Clonazepam because the risk of seizures may be increased

Topiramate because the risk of high ammonium levels, brain problems, or an unusual drop in body temperature may be increased

Acyclovir, cancer medicines, carbapenem antibiotics (eg, ertapenem, imipenem, meropenem), cholestyramine, hydantoins (eg, phenytoin), mefloquine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral contraceptives (eg, birth control pills), or rifampin because they may decrease Depakote's effectiveness

Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital), ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine because the risk of their side effects may be increased by Depakote.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Depakote may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Depakote may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Depakote with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Depakote; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Inflammation of the pancreas is a potentially life-threatening illness associated with Depakote. Symptoms include stomach pain, vomiting, or loss of appetite. Contact your doctor at once if any of these symptoms occur.

Patients who take Depakote may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Patients who have bipolar (manic-depressive) illness may also have an increased risk for suicidal thoughts or actions. Watch patients who take Depakote closely. Contact the doctor at once if new, worsened, or sudden symptoms, such as depressed mood; anxious, restless, irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Depakote may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.

Tell your doctor or dentist that you take Depakote before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Depakote may cause the results of some tests for urine ketones to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.

Depakote may increase the ammonia levels in your blood. Contact your doctor right away if you experience unexplained sluggishness and vomiting or mental changes.

Depakote may cause an unusual drop in body temperature (hypothermia). Symptoms may include confusion, lack of energy, loss of coordination, shivering, slow heartbeat, slow or shallow breathing, slurred speech, or unusual drowsiness. Contact your doctor right away if you have any of these symptoms.

Depakote may interfere with certain lab tests, including thyroid function. Be sure your doctor and lab personnel know you are taking Depakote

Lab tests, including complete blood cell counts, blood ammonia levels, and liver function, may be performed while you use Depakote. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Depakote with caution in the elderly; they may be more sensitive to its effects, especially drowsiness.

Depakote should be used with extreme caution in children younger than 10 years old; safety and effectiveness in these children have not been confirmed. Children younger 2 years may be at increased risk of serious liver problems.

Pregnancy and breast-feeding: Depakote has been shown to cause harm to the fetus. Use an effective form of birth control while you take Depakote. If you think you may be pregnant or if you wish to become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Depakote while you are pregnant. Depakote is found in breast milk. Do not breastfeed while you are taking Depakote.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Change in appetite; constipation; diarrhea; dizziness; drowsiness; hair loss; headache; indigestion; nausea; stomach cramps or pain; trouble sleeping; vomiting; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; change in menstrual period; changes in behavior; chest pain; confusion; dark, tarry, or bloody stools; dark urine; difficulty speaking; difficulty urinating or other urination problems; extreme tiredness; fast or irregular heartbeat; hallucinations; hearing loss; involuntary movements of the arms and legs; involuntary movements or chewing movements of the face, jaw, mouth, or tongue; joint pain; lack of energy; loss of appetite; loss of coordination; loss of seizure control; memory loss; new or worsening mental or mood changes (eg, aggressiveness, agitation, anxiety, depression, exaggerated feeling of well-being, hostility, impulsiveness, inability to sit still, irritability, panic attacks, restlessness); nosebleed; pounding in the chest; red, swollen, blistered, or peeling skin; severe or persistent nausea, vomiting, or stomach pain; shortness of breath; suicidal thoughts or actions; swelling of the arms or legs; symptoms of infection (eg, fever, chills, sore throat); tremor; unusual bleeding or bruising; unusual weakness; vision changes or blurred vision; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



Buy Online Depamag, Depamag

Cupid - Definition Of Cupid By The Free Dictionary, Cupid

Cupid

References in classic literature ?

The dim light fell tenderly on the two quiet seated figures; on the little white bed, with the knots of rose-colored ribbon which looped up its curtains, and the bright dress for dinner laid ready across it; on the gayly painted bath, with its pure lining of white enamel; on the toilet-table with its sparkling trinkets, its crystal bottles, its silver bell with Cupid for a handle, its litter of little luxuries that adorn the shrine of a woman's bed-chamber.

For, what would staid British responsibility and respectability have said to orange-trees in boxes in a Bank courtyard, and even to a Cupid over the counter?

As we got more and more into debt breakfast became a hollower and hollower form, and, being on one occasion at breakfast-time threatened (by letter) with legal proceedings, "not unwholly unconnected," as my local paper might put it, "with jewellery," I went so far as to seize the Avenger by his blue collar and shake him off his feet - so that he was actually in the air, like a booted Cupid - for presuming to suppose that we wanted a roll.

Among pennons and flags bearing wounded hearts, burning hearts, bleeding hearts, bows and quivers, and all the commonplace emblems of the triumphs of Cupid. a blazoned inscription informed the spectators, that this seat of honour was designed for La Royne de la Beault

From his earliest childhood he heard nothing but stories of princes who had fallen into all sorts of troubles through love; and she drew such terrible pictures of poor little Cupid that the young man had no difficulty in believing that he was the root of all evil.

Even at the present time, each check of the American Telephone and Telegraph Company carries on it a picture of a pretty Cupid. sitting on a chair upon which he has placed a thick book, and gayly prattling into a telephone.

At the feet of Death was the god called Cupid. without his bandage, but with his bow, quiver, and arrows; there was also a knight in full armour, except that he had no morion or helmet, but only a hat decked with plumes of divers colours; and along with these there were others with a variety of costumes and faces.

A mantle-piece, with two modern Sevres vases, a timepiece representing Cupid with his bent bow, a mirror with an engraving on each side -- one representing Homer carrying his guide, the other, Belisarius begging -- a grayish paper; red and black tapestry -- such was the appearance of Lord Wilmore's drawing-room.

At last, however, it seemed clear that Cupid had found a sharper arrow than usual, and that Mr.

And off I started, cursorily glancing sideways as I passed the toilet-table, surmounted by a looking-glass: a thin irregular face I saw, with sunk, dark eyes under a large, square forehead, complexion destitute of bloom or attraction; something young, but not youthful, no object to win a lady's love, no butt for the shafts of Cupid .

And the Nelumbo bud that floats for ever With Indian Cupid down the holy river - Fair flowers, and fairy

and Dr Cupid said that when jealousy flew out of the window indifference came in at the door, and that I must exhibit pleasure in the society of other gentlemen and mark your demeanour.



Buy Online Cupid - Definition Of Cupid By The Free Dictionary, Cupid

Cetrin, Cetrin

Citrine

Alternate Names & Name Spellings: Success Stone, Merchant's Stone, Citrina, Citron

Crystals Meanings of Citrine

Keywords: Success, Abundance, Personal Power

Citrine is a joyful stone with bright energy which lights up many aspects of lives of those who work with it. It has energies of good fortune and good luck, though these may appear in unexpected ways.

Citrine is well known in crystal work as a success and prosperity stone to the point that it is called the "Success Stone." It is said to promote and manifest success and abundance in all areas, and in many ways. It is particularly used to promote success in business if used in the cash box of a shop, carried or worn, earning it another nickname, "Merchant's Stone." In addition to manifesting abundance, citrine also brings energies of generosity so that the prosperity and success is shared.

Citrine is a solar plexus chakra stone used metaphysically to increase, magnify and clarify personal power and energy. This increased personal power can be used for the focused intent of the individual, as it brings will power as well.

Citrine is a fabulous stone to use to combat negative energy of any kind by breaking them up and dissipating them. It is helpful to clear unwanted energies from the environment, whether it be home, office, car, or other space indoors or out. Family issues caused by negative energies can also be cleared for resolution with citrine. Citrine is also a stone that brings hope. Since citrine eliminates negative energies, it is good for protection in general and helps bring stability energetically.

Citrine also does not absorb any negative energies from its surroundings, and thus never needs energetic clearing.

Because citrine can clear negative energy and influences from the aura, it is useful for meditation, psychic awareness, and spiritual development. By removing unwanted energies it paves the way for this spiritual and psychic growth. It is also excellent for dream recall and dream work.

In the mental arena, citrine enhances mental clarity, confidence, and will power. The mental clarity and confidence support bringing increased creativity and honesty.

Since citrine brings self-confidence as well as positive energy, it can also help eliminate fears of being judged or of others' ideas. It is also used to dissipate fear of being alone or unworthy of love.

Citrine is a happy stone. It can bring happiness to the person who carries or wears it. Because of its removal of negative energy and its own bring positivity, it can relieve depression, self-doubt, anger, and irrational mood swings.

Citrine is used to reduce self-destructive tendencies. Citrine can help overcome emotional traumas and grief that may lead to these emotionally self-destructive issues.

In crystal healing and healing folklore, citrine is said to be beneficial for the digestion, stomach, nightmares, other sleep disturbances, thyroid, general health, heart, kidney, liver, muscles, strength, endocrine system, circulatory system, tissue regeneration, urinary system, immune system, diabetes, fibromyalgia. Citrine is also reputed to be good for removing toxins, and overcoming addictions. Sensuality and sexuality can also be heightened by citrine making it a stone of positive choice for sexual issues.

Note that healing crystal meanings are spiritual supports to healing and are not prescriptions or healthcare information.

Citrine is associated primarily with the solar plexus chakra .

Citrine is yellow/gold quartz. S ee the Quartz page for mineral data, and additional metaphysical properties and healing properties common to all quartz stones.

More on Citrine, from My Personal Perspective

Perspectives and opinions are often sharply divided as to whether natural and heat treated citrine have the same metaphysical properties. I feel that if nothing else, they have very similar energy due to correspondences of color energy and energetic intent on the part of those using it. Additionally, heat treating amethyst into a citrine color is the manmade version of what mother nature does herself. Like no two crystals growing next to each other in the earth have exactly the same energy, neither would natural and man-heat treated citrine, though they would be similar. One of the primary differences I've found over the years is that the energy of the natural stones seems a bit more focused to me. Working with the intent of doing the highest good for all concerned can ameliorate the mildly scattered feeling of heat treated citrine. Since this is something an energy worker or crystal healer would normally do in the course of his or her efforts it's not an onerous task to take on to smooth out the energy of any crystal including citrine.

" In some Amethyst deposits, the Amethyst has been partially or fully changed over to yellow Citrine by natural means of heating. - See more at: http://www. minerals. net/mineral/citrine. aspx"

Faceted Citrine Example

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Hat tip to Mindat. org for mineral information on this stone.

Hardness (Mohs): 7 Color(s): Yellow, Golden Yellow, Yellow-Orange, Yellow-Green Lustre: Vitreous Transparency: Translucent, Transparent Common Locations: Brazil, Africa, USA

Rock Lore & Tidbits: Citrine is a yellow variety of quartz. Stones that gather their color from inclusions or surface coatings are technically not citrine. In practice, because natural citrine is harder to find, much citrine on the market is treated amethyst or smoky quartz which is heated to make a type of treated citrine.

This original article is Copyright @2013 Robyn A Harton dba Robyn A Harton Creative All rights Reserved. It is based on my previous original article on citrine. To request required permission to post or use my text or photos ask for licensing information here.

Crystal meanings and spiritual healing lore are not prescription, diagnosis or healthcare information. They are presented as spiritual supports to healing and other life issues. See a doctor or licensed medical practitioner for all health issues.

All products are intended for ages 18 and older due to small parts or potential for breaking into small parts and potential choking hazards.

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Some links are sponsored affiliate or ad links which I may get compensation for. My opinions are nonetheless my own and are presented as such. More on all that at the terms page .

COPYRIGHT @2002-2016: All Rights Reserved by Robyn A Harton unless otherwise noted. If you wish to use my writings, etc. rather than write your own from the general information, I grant limited permission to quote from my articles as shown here. and you must ask for licensing information for items longer than brief quotes or to use my photos here. Thanks!



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Is Venous Insufficiency A Side Effect Of Renivace ( ), Renivace

About this FactMed analysis covering adverse side effect reports of RENIVACE patients who developed VENOUS INSUFFICIENCY.

FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 1 individuals taking RENIVACE reported VENOUS INSUFFICIENCY to the FDA. A total of 1237 RENIVACE drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication.

FDA Research Report

Introduction This page is designed to help you determine the relationship, if any, between RENIVACE and VENOUS INSUFFICIENCY. In doing so, we compare RENIVACE with other drugs that cause VENOUS INSUFFICIENCY, to help you evaluate whether or not RENIVACE causes VENOUS INSUFFICIENCY. Likewise, this page shows the most highly-reported side effects of RENIVACE, so you can see if VENOUS INSUFFICIENCY ranks among RENIVACE's most well-known side effects.

Summary Statistics Reports of RENIVACE causing VENOUS INSUFFICIENCY: 1 Reports of any side effect of RENIVACE. 1237 Percentage of RENIVACE patients where VENOUS INSUFFICIENCY is a reported side effect: 0.0808%

FDA reports of any drug causing VENOUS INSUFFICIENCY. 1311 Average percentage for all medicated patients where VENOUS INSUFFICIENCY is reported as a complication: 0.0082%

Physician opinion on RENIVACE as adverse event culprit:



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Benzoyl Peroxide

S. J. Enna

University of Kansas Medical Center, Kansas City, USA

David B. Bylund

University of Nebraska Medical Center, Omaha, USA

Available online 8 January 2008.

Basic information has been imported into this record. If you have more information on this agent and would like to become an xPharm contributor, please contact us at xpharm-admin@elsevier. com .

Name of the Clinical Form Related Names Source: EMTREE

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No tome leflunomida si esta embarazada o planea quedar embarazada. La leflunomida puede causar danos al feto. No debe comenzar a tomar leflunomida hasta que se haya realizado una prueba de embarazo con resultados negativos y su medico le diga que no esta embarazada. Debe usar un metodo anticonceptivo efectivo antes de comenzar a tomar leflunomida, durante su tratamiento con leflunomida y durante 2 anos despues del tratamiento. Si su periodo se atrasa o si no se le presenta un periodo durante el tratamiento con leflunomida, llame a su medico de inmediato. Digale a su medico si planea quedar embarazada dentro de los 2 anos posteriores a interrumpir el tratamiento con leflunomida. Su medico puede recetarle un tratamiento para ayudarlo a eliminar este medicamento mas rapidamente de su cuerpo.

La leflunomida puede causar danos en el higado que podrian poner en riesgo la vida e incluso provocar la muerte. El riesgo de desarrollar danos en el higado es mayor en las personas que toman otros medicamentos que se sabe que provocan danos en el higado y en las personas que ya tienen enfermedad del higado. Informe a su medico si tiene o ha tenido alguna vez hepatitis o algun otro tipo de enfermedad del higado y si bebe o alguna vez ha bebido alcohol en grandes cantidades. Informe a su medico y a su farmaceutico si esta tomando acetaminofen (Tylenol, en otros productos de venta sin receta), aspirina y otros medicamentos antiinflamatorios no esteroides (NSAID, por sus siglas en ingles) (como ibuprofeno [Advil, Motrin] y naproxeno [Aleve, Naprosyn], medicamentos reductores del colesterol (estatinas), hidroxicloroquina, productos de hierro, isoniazida (Laniazid, en Rifamate, en Rifater), metotrexato (Trexall), niacina (acido nicotinico) o rifampina (Rifadin, Rimactane, en Rifamate, en Rifater). Si presenta alguno de los siguientes sintomas, llame a su medico de inmediato: nauseas, cansancio extremo, sangrado o moretones inusuales, falta de energia, perdida del apetito, dolor en la parte superior derecha del abdomen, coloracion amarillenta en la piel o los ojos, orina de color oscuro o sintomas parecidos a los de la gripe.

No falte a ninguna cita, ni con su medico ni con el laboratorio. Su medico ordenara determinadas pruebas para ver como responde su organismo a la leflunomida.

Consulte a su medico sobre los riesgos de tomar leflunomida.

?Para cuales condiciones o enfermedades se prescribe este medicamento?

La leflunomida se usa sola o en combinacion con otros medicamentos para tratar la artritis reumatoide (una afeccion en la que el cuerpo ataca sus propias articulaciones, lo que provoca dolor, inflamacion y perdida de la funcion). La leflunomida pertenece a una clase de medicamentos llamados medicamentos antirreumaticos modificadores de la enfermedad (DMARD, por sus siglas en ingles). Actua disminuyendo la inflamacion y enlenteciendo el progreso de la afeccion, lo que puede ayudar a mejorar la actividad fisica de personas con artritis reumatoide.

?Como se debe usar este medicamento?

La presentacion de la leflunomida es en tabletas para administrarse por via oral. Suele tomarse una vez al dia. Es posible que su medico le indique que aumente la dosis de leflunomida durante los primeros 3 dias de tratamiento. Siga atentamente las instrucciones del medicamento recetado, y pidales a su medico o a su farmaceutico que le expliquen cualquier cosa que no entienda. Tome leflunomida segun lo indicado. No aumente ni disminuya la dosis, ni la tome con mas frecuencia que la indicada por su medico.

Es posible que su medico disminuya su dosis o interrumpa el tratamiento si usted presenta determinados efectos secundarios graves. No olvide decirle a su medico como se siente durante su tratamiento.

La leflunomida puede ayudar a controlar los sintomas de su artritis reumatoide, pero no la cura. Siga tomando leflunomida aunque se sienta bien. No deje de tomar leflunomida sin consultar a su medico.

?Que otro uso se le da a este medicamento?

Este medicamento puede recetarse para otros usos; pidales mas informacion a su medico o a su farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes de tomar leflunomida:

Informe a su medico y a su farmaceutico si es alergico a la leflunomida, teriflunomida (Aubagio), a algun otro medicamento, o a alguno de los ingredientes de las tabletas de leflunomida. Pidale a su farmaceutico una lista de los ingredientes.

Informe a su medico y a su farmaceutico que otros medicamentos con y sin receta, vitaminas, suplementos nutricionales y productos herbarios esta tomando o planea tomar. No olvide mencionar los medicamentos que aparecen en la seccion ADVERTENCIA IMPORTANTE ni ninguno de los siguientes: anticoagulantes ("diluyentes de la sangre") como warfarina (Coumadin, Jantoven); colestiramina (Prevalite); compuestos de oro, como auranofina (Ridaura); medicamentos para tratar el cancer; otros medicamentos supresores del sistema inmunitario, como azatioprina (Azasan, Imuran), ciclosporina (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) y tacrolimus (Astagraf, Prograf); penicilamina (Cuprimine, Depen), y tolbutamida. Es posible que su medico deba cambiar las dosis de sus medicamentos o vigilarlo de cerca por si presentara efectos secundarios.

Informe a su medico si tiene o ha tenido infecciones graves o si contrae con frecuencia infecciones, si tiene o ha tenido cancer u otras afecciones que afecten la medula osea o el sistema inmunitario (incluido el virus de la inmunodeficiencia humana [VIH] y el sindrome de inmunodeficiencia adquirida [SIDA]), diabetes, o enfermedad de los rinones.

Informe a su medico si esta dando el pecho. No amamante mientras esta tomando leflunomida.

Si planea tener un hijo con su pareja, debe hablar con su medico acerca de dejar de tomar leflunomida y empezar a recibir un tratamiento que ayude a eliminar este medicamento de su cuerpo mas rapidamente.

Preguntele a su medico si puede consumir bebidas alcoholicas de manera segura mientras este tomando leflunomida.

Tomar leflunomida puede disminuir su capacidad para combatir infecciones. Informe a su medico si tiene una infeccion o si tiene signos de infeccion, como fiebre, tos o sintomas parecidos a los de la gripe. Si presenta alguno de los siguientes sintomas durante su tratamiento con leflunomida, llame a su medico: fiebre; dolor de garganta; tos; sintomas parecidos a los de la gripe; calor, enrojecimiento, hinchazon o dolor en un area de la piel; ganas frecuentes de orinar, dificultad o dolor al orinar; u otros signos de infeccion. Es posible que deba interrumpirse su tratamiento con leflunomida si tiene una infeccion.

Es posible que tenga tuberculosis (TB; una infeccion pulmonar grave) aunque no presente ningun sintoma de la enfermedad. En tal caso, la leflunomida puede agravar la infeccion y provocarle sintomas. Informe a su medico si tiene o alguna vez ha tenido TB, si ha vivido en algun pais donde la TB es comun o visito este pais, o si ha estado en contacto con una persona que tiene o ha tenido TB. Antes de comenzar el tratamiento con leflunomida, su medico le hara una prueba cutanea para ver si tiene TB. De tenerla, su medico tratara esta infeccion con antibioticos antes de comenzar el tratamiento con leflunomida.

No se aplique ninguna vacuna sin consultar a su medico.

Tenga en cuenta que la leflunomida puede provocar presion arterial alta. Debe medirse la presion arterial antes de comenzar el tratamiento y periodicamente mientras toma este medicamento.

?Que tengo que hacer si me olvido de tomar una dosis?

Si olvida tomar una dosis, tomela en cuanto se acuerde. No obstante, si ya casi es hora de la dosis siguiente, deje pasar la que olvido y continue con su horario de medicacion normal. No tome una dosis doble para compensar la que olvido.

?Cuales son los efectos secundarios que podria provocar este medicamento?

La leflunomida puede provocar efectos secundarios. Informe a su medico si alguno de estos sintomas es intenso o no desaparece:

diarrea

vomitos

acidez estomacal

dolor de cabeza

mareos

perdida de peso

dolor de espalda

dolor o debilidad muscular

dolor, ardor, entumecimiento u hormigueo en las manos o los pies

perdida del cabello

calambres en las piernas

piel seca

Algunos efectos secundarios pueden ser graves. Si presenta alguno de los siguientes sintomas o de los mencionados en la seccion ADVERTENCIA IMPORTANTE o la seccion PRECAUCIONES ESPECIALES, llame a su medico de inmediato o busque tratamiento medico de emergencia:

sarpullido con o sin fiebre

urticaria

llagas en la boca

picazon

dificultad para respirar

aparicion o empeoramiento de la tos

dolor en el pecho

ampollas o descamacion de la piel

palidez

Recibir medicamentos supresores del sistema inmunitario puede aumentar el riesgo de desarrollar determinados tipos de cancer. No se informo un aumento de cancer en estudios clinicos con leflunomida hasta la fecha. Consulte a su medico sobre los riesgos de recibir leflunomida.

La leflunomida puede provocar otros efectos secundarios. Llame a su doctor si tiene cualquier problema inusual mientras toma este medicamento.

Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgacion de efectos adversos 'MedWatch' de la Administracion de Alimentos y Medicamentos (FDA, por su sigla en ingles) en la pagina de Internet (http://www. fda. gov/Safety/MedWatch ) o por telefono al 1-800-332-1088.

?Como debo almacenar o desechar este medicamento?

Mantenga este medicamento en su envase original, bien cerrado y fuera del alcance de los ninos. Almacenelo a temperatura ambiente y en un lugar alejado del exceso de calor y humedad (nunca en el cuarto de bano) y de la luz.

Los medicamentos que ya no son necesarios se deben desechar de una manera apropiada para asegurarse de que las mascotas, los ninos y otras personas no puedan consumirlos. Sin embargo, no debe desechar estos medicamentos por el inodoro. En su lugar, la mejor manera de deshacerse de sus medicamentos es a traves de un programa de devolucion de medicamentos. Hable con su farmaceutico o pongase en contacto con su departamento de basura/reciclaje local para conocer acerca de los programas de devolucion de medicamentos de su comunidad. Consulte el sitio web de la Administracion de Medicamentos y Alimentos (FDA), (http://goo. gl/c4Rm4p ) para obtener mas informacion de como desechar de forma segura los medicamentos, si no tiene acceso al programa de devolucion de medicamentos.

?Que debo hacer en caso de una sobredosis?

En caso de una sobredosis, llame a la oficina local de control de envenenamiento al 1-800-222-1222. Si la victima esta inconsciente, o no respira, llame inmediatamente al 911.

Los sintomas de sobredosis son, entre otros, los siguientes:

diarrea

dolor de estomago

cansancio extremo

debilidad

palidez

latidos cardiacos rapidos

falta de aire

?Que otra informacion de importancia deberia saber?

No deje que ninguna otra persona tome sus medicamentos. Preguntele a su farmaceutico como puede volver a surtir su receta.

Es importante que Ud. mantenga una lista escrita de todas las medicinas que Ud. esta tomando, incluyendo las que recibio con receta medica y las que Ud. compro sin receta, incluyendo vitaminas y suplementos de dieta. Ud. debe tener la lista cada vez que visita su medico o cuando es admitido a un hospital. Tambien es una informacion importante en casos de emergencia.

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Colospa (Mebeverine) is used to relieve cramps or spasms of the stomach and intestines (gut). It is particularly useful in treating irritable bowel syndrome (IBS) and similar conditions. Consult your physician for further Colospa (Mebeverine) applications.

Availability: In Stock (25 packs)

Colospa prevents nerve signals passing through to the muscle in the intestines. It helps the muscle to relax, preventing painful spasm.

Take exactly as prescribed by your Health Provider.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

You should take 135 mg Colospa hydrochloride (1 tablet) 3 times a day, before meals. After a few weeks of treatment when the health-giving effect has been obtained, the dosage may be gradually lowered.

Store this medicine at room temperature in a tightly-closed container, away from heat and light.

Use Colospa with caution in the following cases: failure of function of part of the gut causing an obstruction (paralytic ileus); life long inherited blood diseases which can cause a variety of symptoms, including mental health problems (porphyrias).

In case you become pregnant, consult with your doctor and discuss the benefits and risks of taking Colospa while pregnancy. The safety of Colospa 135 mg in pregnancy has not been proved. In case you are or will be breast-feeding a baby while you use Colospa, consult with your doctor and discuss any possible risks to your baby. The harmful effects are not known in case this medicine is used while breastfeeding a baby.

Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Some medicines or medical conditions may interact with this medicine. Inform your doctor or pharmacist of all prescription and over-the-counter medicine that you are taking.

You should consult with your doctor in case you have any of side effects especially bothersome listed below: Constipation, confusion, agitation.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

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Prodajem ili menjam lek Darob mite 80mg. Jedna kutija sadrzi 50 tableta od po 80mg. Imam 6 kutija. Navedena cena odnosi se na jednu kutiju. U obzir dolazi zamena za neki vid suplementa na primer: vitamini, minerali, omega369 masne kiseline, koenzim Q 10 ili suplementi za podrsku zglobovima. Takodje u obzir dolazi i zamena za lek AVIL. Lek vazi do 06.2017 i 02.2019. Lek je originalan i kupljen u apoteci, prodajem ga jer mi je promenjena kompletna terapija i sada nemam koristi od njega a samo jedna kutija inace kosta 550din.

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Diclofenac is used primarily for the treatment of inflammation and pain caused by conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is also effective in treating soft tissue inflammations due to tendinitis and bursitis, and treating dysmenorrhea (menstrual cramps). Diclofenac is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Diclofenac as directed by your doctor!

Take Diclofenac by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Diclofenac with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Diclofenac, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diclofenac.

Store Diclofenac at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do NOT use Diclofenac if:

you are allergic to any ingredient in Diclofenac or to bovine (cow) protein

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you have severe kidney problems

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if this applies to you.

Some medical conditions may interact with Diclofenac. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders (eg, porphyria), bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you smoke, drink alcohol, or have a history of alcohol abuse

if you are taking an antibiotic or an anti-seizure medicine. The risk of liver problems may be increased with some of these medicines.

Some medicines may interact with Diclofenac. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), heparin and other blood thinners (eg, dalteparin), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Acetaminophen because the risk of liver problems may be increased

Probenecid because it may increase the risk of Diclofenac's side effects

Cyclosporine, lithium, metformin, methotrexate, oral NSAIDs (eg, ibuprofen), or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Diclofenac

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Diclofenac.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diclofenac may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Diclofenac may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Diclofenac. Taking it in high doses, for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Diclofenac with food will NOT reduce the risk of these effects. If you have severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling, contact your doctor or emergency room right away.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Diclofenac is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Diclofenac unless your doctor tells you to.

Check with your doctor or pharmacist before you take acetaminophen while you are taking Diclofenac. The risk of liver problems may be increased.

Do not switch between different forms of Diclofenac (eg, enteric-coated tablets, immediate-release tablets, capsules) unless your doctor tells you to. They may not provide the same amount of medicine to your body.

Lab tests, including kidney function, liver function, blood electrolyte levels, complete blood cell counts, and blood pressure, may be performed while you use Diclofenac. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Diclofenac with caution in the elderly; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.

Diclofenac should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Diclofenac may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breastfeed while taking Diclofenac.



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Patent Cn102492748a - Method For Keeping Stable Monacolin K Content In Red Yeast Rice - Google Paten

Method for keeping stable Monacolin K content in red yeast rice CN 102492748 A

The invention provides a method for keeping stable Monacolin K content in red yeast rice in an industrial production process. The method provided by the invention is a method for adopting freeze drying or vacuum drying and combining electronic accelerator sterilization in the production process of the red yeast rice, so that the Monacolin K content in the red yeast rice and stable proportion and content of an acid type structure and a lactone type structure are effectively kept, and the problem of control over the total number of colonies in a product at normal temperature is effectively solved. The red yeast rice treated by the method provided by the invention has water content of less than 1.2 percent; the total Monacolin K content in red yeast rice is 600-1,200 mg/100 g; the content of the acid type structure of the Monacolin K in red yeast rice accounts for 93-97 percent of the total Monacolin K content; the content of the lactone type structure of the Monacolin K in red yeast rice only accounts for 3-7 percent of the total Monacolin K content; the total number of the colonies in the red yeast rice is less than 1,000 cfu/g; the coli groups are less than 30 MPN/100 g; the mold and the yeast are less than 100 cfu/g; and the pathogen is not detected.

Патентная формула (6) (язык оригинала: китайский )

1. ???????Monacolin K???????,??????????:(1)?????????????????????????????;???????????????-45?-?°C,?????M?60h ;O)????????????????(1)?????????????;???????????4?14kw,?????10?lOOkGy,?????0. 5?5min? A red yeast Monacolin K content in a stable way to keep characterized by specific steps include: (1) freeze-drying apparatus usual industrial production of red yeast fermentation and freeze-dried dehydrated; freeze-drying process conditions require drying temperature To -45

-? ° C, the drying time is M

60h; O), the use of electron accelerators for industrial usually after step (a) dried red yeast irradiation sterilization; using electron accelerator power 4

14kw. exposure dose 10

lOOkGy, the irradiation time is 0. 5

2.??????1?????,?????????????????-38?-32 °C,?????36?48h? 2. The method according to claim 1 or claim 2, wherein the step of freeze-drying temperature ? according to -38

-32 ° C, the drying time is 36

3.??????1?2?????,??????(2)????????1?2min? 3. The method according to claim 1 or claim 2, wherein the step of irradiation time (2) according to 1

4. ???????Monacolin K???????,??????????:(1)?????????????????????????????;???????????????40?65°C,????-550?-780mbar,?????36?72h ;O)????????????????(1)?????????????;???????????4?14kw,?????10?lOOkGy,?????0. 5?5min? 4. A red yeast Monacolin K content in a stable way to keep characterized by specific steps include: (1), using industrial vacuum drying equipment is usually the production of red yeast fermentation vacuum dehydration; vacuum drying process conditions require drying temperature for 40

65 ° C, vacuum degree of -550

-780mbar, drying time is 36

72h; O), the use of electron accelerators for industrial usually by step (1) red yeast rice drying process irradiation sterilization; adopted electron accelerator power 4

14kw, the radiation dose for 10

lOOkGy, irradiation time is 0. 5

5.??????4?????,??????(1)??????????50?55°C, ????-650?-720mbar,?????48?60h? 5. A method according to claim 4, wherein, wherein the vacuum drying temperature in step (1) above is 50

55 ° C, a vacuum degree of -650

-720mbar, drying time 48

6.??????4?5?????,??????(2)????????1?2min? 6. The method according to claim 4 or claim 5, wherein the step of irradiation time (2) according to 1

Описание (язык оригинала: китайский )

???????Monacol in K??????? A method of maintaining red yeast Monacol in K content in a stable way

[0001] ???????????Monacolin?????????????????? [0001] The present invention relates to a red song Monacolin content remains stable in the industrial production process methods. ???? BACKGROUND

[0002] ??????????????????? [0002] has been applied to the traditional red yeast rice as a food coloring and medicinal. ??FDA?1987????????(????,Lovastatin)????? US FDA in 1987 formally approved Mevacor (lovastatin, Lovastatin) for clinical use. ??????Monacolin K(??????)???????????????,??????????????????HMG-CoA???????????????? Natural red yeast in Monacolin K (also known as lovastatin) is red yeast rice has significant physiological activity of substances can inhibit cholesterol biosynthesis pathway, a key enzyme HMG-CoA reductase, which plays the role of lipid-lowering effect. ????Monacolin K???????,?????????????????? Red yeast rice in Monacolin K exists in two forms, namely open-loop and closed-loop structure acid lactone structure. ????,???????????Monacolin K?HMG-CoA????????????,?????????Monaco 1 in K??????,?????????????????????Monacolin K,???????????????,??????????? The study found, Monacolin K acid lactone structure than the structure of HMG-CoA reductase inhibitory effect is more significant, after taking to the lactone structure of Monaco 1 in K of lipid-lowering drugs, the body will produce a carboxyl esterase hydrolyzed to acid structure Monacolin K, this process will result in human liver and kidney burden, adverse effect on some people.

[0003] ????Monacolin K???????????,???????,Monacolin K ????????????????? [0003] Red song structure and acid lactone structure Monacolin K, the difference between a water molecule, acid structure Monacolin K is usually combined with water to form. ????,????????????????????Monacolin K??,?pH?????????????????????,??????????????????????????? The study found that red yeast rice in the industrial manufacturing process, many factors affect Monacolin K content, such as pH, sterilization temperature and time of the production process, the drying temperature and time, and the radiation dose will affect the structure and acid lactone structure The proportion and contents. ??????????????????,??????????????????? Because red yeast Monascus growth and development during the fermentation process, resulting in the total number of colonies than the product of food hygiene standards. ??????????????????,?????????,??Monacolin K?????,????????Monacolin K ????,????????? Commonly used industrial heating temperature and high pressure sterilization method, not only affect the color of products, content and Monacolin K decline, especially Monacolin K proportion dropped acid structure, resulting in decreased product quality. ???????????????,??????????????????????Monacol in K??????,??????????Mcmacol in K? Monascus removed during drying of the free water, but a longer time will inevitably result in a high temperature drying the acid type structure Monacol in K loses its water of hydration, and converted to the lactone structure of Mcmacol in K. ?????-60????????,???????????Monacolin K?????, ????Monacolin K????10%?,????????????????????????? If adopted by the cobalt-60 irradiation sterilization processing Monacolin K content, structure and acid lactone structure were decreased after irradiation Monacolin K content decreased by 10%, and a decrease in acid structure is significantly greater than in the decline ester type structure. ????????????????????????????????-60 ???????,????????????????Monacolin K?????????????? Because red yeast moist heat sterilization in industrial manufacturing processes require sterilization taken, and the high-temperature drying process measures, such as cobalt-60 irradiation, significantly affect the content of red yeast key Monacolin K physiologically active substances to reduce and acid structure conversion.

[0004] ???????????????Monacolin K?????????????????? [0004] The present invention is to provide a Monacolin K content in red yeast stable method in industrial production processes.

[0005] ????????????????????????????????????????????,??????????????Monacolin K??????????????????????? [0005] The method of the invention is the use of freeze-dried or vacuum-dried and combined electron accelerator irradiation sterilization method in red yeast production process, the effective protection of red yeast Monacolin K content and acid structure in industrial processes and the ratio of the content of the lactone structure and stability.

[0006] ????????????: [0006] The specific steps of the method of the present invention comprises:

[0007] (1)??????????????????????????(???)?????????????,??????????;???????????????-45?-?°C,?????M?60h,?????????-38?-32°C,?????36?48h ;???????????????40?65°C,????-550?-780mbar,?????36?72h,??????????50?55°C,????-650?-720mbar,?????48 ?60h ; [0007] (1), the use of industrial drying devices typically freeze-dried or vacuum produced by the fermentation of red yeast (Monascus) freeze-dried or vacuum dehydration, effectively removing MONASCUS free water; freeze-drying process conditions require dry temperature of -45

-? ° C, the drying time is M

60h, the optimum temperature was lyophilized to -38

-32 ° C, the drying time is 36

48h; vacuum drying process conditions require a drying temperature of 40

65 ° C, vacuum degree of -550

-780mbar, the drying time is 36

72h, the optimal temperature of the vacuum drying 50

55 ° C, a vacuum degree of -650

-720mbar, the drying time is 48

[0008] O)????????????????(1)?????????????,?????????????????;???????????4?14kw,?????10? lOOkGy,?????0. 5?5min ;???????1?anin? [0008] O), the use of electron accelerators for industrial usually after step (a) dried red yeast irradiation sterilization, so that red yeast microbial indicators in line with food hygiene standards; using electron accelerator power 4

14kw, spoke Dose for 10

lOOkGy, irradiation time is 0. 5

5min; optimal exposure time for 1

[0009] ???,??????????????,???????1.2%,????Monacolin K???600?1200mg/100g,????Monacolin K?????????Monacolin K???93?97 %,????Monacolin K?????????????Monacolin K???3?7% ;?????????1000cfu/g,??????30MPN/100g, ???????lOOcfu/g,??????? [0009] After testing, the above-mentioned process of the invention after the red yeast rice, the moisture content of less than 1.2% of the total red yeast Monacolin K content 600

1200mg / 100g, the acid content of red yeast rice in the structure of Monacolin K 93

97% Monacolin K content of the total of red yeast Monacolin K lactone structure content only 3

7% of the total red yeast Monacolin K content; red yeast is less than the total number of colonies 1000cfu / g, coliform group below 30MPN / 100g, molds and yeasts less than lOOcfu / g, pathogen not detected.

[0010] ???????????????????????????,????????????,??????????????Monacolin K????????????,???????????Monacolin K??????????????????????????,????????????????????,????????Monacolin K??????????? [0010] The present invention by freeze-drying or vacuum drying process removed MONASCUS free water, combined with electron accelerator radiation processing, not only in the industrial production process so that the red yeast Monacolin K content and acid content which does not fall. and avoid its Monacolin K acid structure extended period of time high-temperature drying process loses its water of hydration is converted into a lactone structure, and an effective solution at room temperature, the total number of products in the control colonies, obtained with a high content of Monacolin K acid structure of red yeast rice products.

[0011] ?????????????????????GZLS-75?GZLS-100?GZLS-125 ???????????,???????-55?120°C ;?????????????????5. O?10. OMeV,?????5?30KW????????? [0011] The present invention relates to a freeze-drying apparatus may be used for industrial model GZLS-75, GZLS-100, GZLS-125 Far series of vacuum freeze-drying machine, shelf operating temperature -55

120 ° C; industry involved energy electron accelerator can be used for 5. O

10. OMeV, electron beam irradiation power 5

[0012] ???????????????(%),???????,???????? [0012] The present invention in various percentage content relates (%), except otherwise noted, are weight percentages.

?????? DETAILED DESCRIPTION

[0013] ???????????????????? [0013] below with reference to embodiments of the present invention will be further described in detail.

[0014] ????: [0014] Embodiment 1:

[0015] 1??????????????????????????????,???????_45°C,?????Mh ;??????????????; [0015] 1, a usual freeze-drying apparatus for industrial fermentative production of Monascus freeze dehydration, freeze-drying temperature of _45 ° C, the drying time is Mh; Monascus off free water in the freeze-drying;

[0016] 2????????????????,???????????,??6kw????????25kGy??????,?????aiiin ; [0016] 2, using the usual industrial electron accelerator irradiation sterilization, reduce microbial indicators MONASCUS using 6kw electron accelerator and uses 25kGy sterilizing radiation dose, irradiation time aiiin;

[0017] 3????,???????????????1. 18%,????Monacolin K???1200mg/100g,????Monacolin K?????????Monacolin K???97%, Monacolin K?????????????Monacolin K???3%,????????920cfu/g,?????25MPN/100g,??????75cfu/g,??????? [0017] 3, after testing, red yeast rice moisture content after the above approach is 1.18%, red yeast total Monacolin K content of 1200mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K 97% of the content, Monacolin K lactone structure content only 3% of the total red yeast Monacolin K content in the total number of red yeast colonies 920cfu / g, coliform was 25MPN / 100g, molds and yeasts for 75cfu / g. pathogenic bacteria were not detected.

[0018] ????: [0018] EXAMPLE II:

[0019] 1??????????????????????????????,???????65°C,????-780mbar,?????48h,??????????????; [0019] 1, using the usual vacuum drying apparatus industrial fermentative production of Monascus vacuum dehydration, vacuum drying temperature of 65 ° C, vacuum degree of -780mbar, drying time was 48h, Monascus off and dried in vacuo in go free water;

[0020] 2???????????????????????????,??Skw????????70kGy??????,?????aiiin ; [0020] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using Skw electron accelerator and uses 70kGy sterilizing radiation dose, irradiation time aiiin;

[0021] 3????,???????????????0.98%,????Monacolin K???1000mg/100g,????Monacolin K?????????Monacolin K???95%,Monacolin K?????????????Monacolin K???5%,????????710cfu/g,?????18MPN/100g,??????45cfu/g,??????? [0021] 3, after testing, red yeast rice moisture content after the above approach is 0.98% of the total red yeast Monacolin K content of 1000mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content 95%, Monacolin K lactone structure content only 5% of the total red yeast Monacolin K content in the total number of red yeast colonies 710cfu / g, coliform was 18MPN / 100g, molds and yeasts for 45cfu / g, cause bacteria were not detected.

[0022] ????: [0022] EXAMPLE III:

[0023] 1??????????????????????????????,???????40°C,????-550mbar,?????72h,??????????????; [0023] 1, using the usual industrial vacuum drying device for fermentation of Monascus vacuum dehydration, vacuum drying temperature of 40 ° C, vacuum degree of -550mbar, drying time is 72h, MONASCUS off in a vacuum drying go free water;

[0024] 2???????????????????????????,??14kw????????SOkGy??????,?????2. 5min ; [0024] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using 14kw electron accelerator and uses SOkGy sterilizing radiation dose, irradiation time was 2. 5min;

[0025] 3????,???????????????0.92%,????Monacolin K ???1100mg/100g,????Monacolin K?????????Monacolin K???95. 5%, Monacolin K?????????????Monacolin K???4. 5%,????????320cfu/g,?????12MPN/100g,??????33cfu/g,??????? [0025] 3, after testing, red yeast rice moisture content after the above approach is 0.92% of the total red yeast Monacolin K content of 1100mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content 95. 5%, Monacolin K lactone structure content only red yeast total Monacolin K content of 4.5%, the total number of red yeast colonies 320cfu / g, coliform was 12MPN / 100g, fungi and yeast 33cfu / g, pathogenic bacteria were not detected.

[0026] ????: [0026] EXAMPLE IV:

[0027] 1??????????????????????????????,???????_32°C,?????48h ;??????????????; [0027] 1, a usual freeze-drying apparatus for industrial fermentative production of Monascus freeze dehydration, freeze-drying temperature of _32 ° C, the drying time was 48h; Monascus off free water in the freeze-drying;

[0028] 2???????????????????????????,??4kw????????IOkGy??????,?????5min ; [0028] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using 4kw electron accelerator and uses IOkGy sterilizing radiation dose, irradiation time is 5min;

[0029] 3????,???????????????1.05%,????Monacolin K???750mg/100g,????Monacolin K?????????Monacolin K???96%, Monacolin K?????????????Monacolin K???4%,????????990cfu/g,?????^MPN/100g,??????98cfu/g,??????? [0029] 3, after testing, red yeast rice moisture content after the above approach is 1.05% of the total red yeast Monacolin K content of 750mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content 96%, Monacolin K lactone structure content is only 4% of the total red yeast Monacolin K content in the total number of red yeast colonies 990cfu / g, coliform is ^ MPN / 100g, molds and yeasts for 98cfu / g, pathogen not detected.

[0030] ????: [0030] Embodiment 5:

[0031] 1??????????????????????????????,???????-M°C,?????36h ;??????????????; [0031] 1, a usual freeze-drying apparatus for industrial fermentative production of Monascus freeze dehydration, freeze-drying temperature is - M ° C, the drying time was 36h; Monascus off free water in the freeze-drying;

[0032] 2???????????????????????????,??IOkw????????70kGy??????,?????aiiin ; [0032] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using IOkw electron accelerator and uses 70kGy sterilizing radiation dose, irradiation time aiiin;

[0033] 3????,???????????????1. 10%,????Monacolin K???1100mg/100g,????Monacolin K?????????Monacolin K???94%, Monacolin K?????????????Monacolin K???6%,????????480cfu/g,?????17MPN/100g,??????50cfu/g,??????? [0033] 3, after testing, red yeast rice moisture content after the above approach is 1.10%, red yeast total Monacolin K content of 1100mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K 94% of the content, Monacolin K lactone structure content only 6% of the total red yeast Monacolin K content in the total number of red yeast colonies 480cfu / g, coliform was 17MPN / 100g, molds and yeasts for 50cfu / g. pathogenic bacteria were not detected.

[0034] ????: [0034] EXAMPLE VI:

[0035] 1??????????????????????????????,???????-40°C,?????50h ;??????????????; [0035] 1, using the usual freeze-drying apparatus for industrial fermentation of Monascus dehydrated and freeze-dried, freeze-drying temperature of -40 ° C, the drying time was 50h; MONASCUS off free water in the freeze-dried;

[0036] 2???????????????????????????,??9kw????????SOkGy??????,?????0. 5min ; [0036] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using 9kw electron accelerator and uses SOkGy sterilizing radiation dose, irradiation time is 0. 5min;

[0037] 3????,???????????????0.96%,????Monacolin K???1200mg/100g,????Monacolin K?????????Monacolin K???97%, Monacolin K?????????????Monacolin K???3%,????????900cfu/g,?????27MPN/100g,??????90cfu/g,??????? [0037] 3, after testing, red yeast rice moisture content after the above approach is 0.96%, red yeast total Monacolin K content of 1200mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content 97%, Monacolin K lactone structure content only 3% of the total red yeast Monacolin K content in the total number of red yeast colonies 900cfu / g, coliform was 27MPN / 100g, molds and yeasts for 90cfu / g, cause bacteria were not detected.

[0038] ????:[0039] 1??????????????????????????????,???????^°C,????-650mbar,?????36h,??????????????; [0038] Example VII: [0039] 1, a usual industrial vacuum drying apparatus for the fermentative production of Monascus vacuum dehydration, vacuum drying temperature is ^ ° C, vacuum degree of -650mbar, drying time was 36h, red aspergillosis off free water and dried in a vacuum;

[0040] 2???????????????????????????,??12kw????????75kGy??????,?????3. 5min ; [0040] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using 12kw electron accelerator and uses 75kGy sterilizing radiation dose, irradiation time was 3. 5min;

[0041] 3????,???????????????1. 0%,????Monacolin K???1100mg/100g,????Monacolin K?????????Monacolin K???96. 5%, Monacolin K?????????????Monacolin K???3. 5%,????????360cfu/g,?????14MPN/100g,??????3kfu/g,??????? [0041] 3, after testing, red yeast rice moisture content after the above approach is 1.0%, the total red yeast Monacolin K content of 1100mg / 100g, red yeast rice in acid structure content Monacolin K total Monacolin K 96.5% content, Monacolin K lactone structure content only red yeast total Monacolin K content of 3.5%, the total number of red yeast colonies 360cfu / g, coliform was 14MPN / 100g, molds and yeasts for 3kfu / g, bacteria were not detected.

[0042] ????: [0042] EXAMPLE VIII:

[0043] 1??????????????????????????????,???????50°C,????-720mbar,?????60h,??????????????; [0043] 1, using the usual industrial vacuum drying device for fermentation of Monascus vacuum dehydration, vacuum drying temperature of 50 ° C, vacuum degree of -720mbar, drying time is 60h, MONASCUS off in a vacuum drying go free water;

[0044] 2???????????????????????????,??IOkw????????75kGy??????,?????Imin ; [0044] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using IOkw electron accelerator and uses 75kGy sterilizing radiation dose, irradiation time for Imin;

[0045] 3????,???????????????1. 05%,????MonacolinK???1150mg/100g,????Monacolin K?????????Monacolin K???96. 5%, Monacolin K?????????????Monacolin K???3. 5%,????????860cfu/g,?????24MPN/100g,??????68cfu/g,??????? [0045] 3, after testing, red yeast rice moisture content after the above approach is 1.05%, red yeast total MonacolinK content of 1150mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content of 96. 5%, Monacolin K lactone structure content only red yeast total Monacolin K content of 3.5%, the total number of red yeast colonies 860cfu / g, coliform was 24MPN / 100g, fungi and yeast 68cfu / g, pathogenic bacteria were not detected.

[0046] ????: [0046] EXAMPLE IX:

[0047] 1??????????????????????????????,???????_38°C,?????^h ;??????????????; [0047] 1, a usual freeze-drying apparatus for industrial fermentative production of Monascus freeze dehydration, freeze-drying temperature of _38 ° C, the drying time for ^ h; Monascus off free water in the freeze-drying;

[0048] 2???????????????????????????,??6kw????????IOOkGy??????,?????-in ; [0048] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using 6kw electron accelerator and uses IOOkGy sterilizing radiation dose, irradiation time - in;

[0049] 3????,???????????????0.95%,????Monacolin K???600mg/100g,????Monacolin K?????????Monacolin K???97%, Monacolin K?????????????Monacolin K???3%,????????780cfu/g,?????19MPN/100g,??????71cfu/g,??????? [0049] 3, after testing, red yeast rice moisture content after the above approach is 0.95% of the total red yeast Monacolin K content of 600mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content 97%, Monacolin K lactone structure content only 3% of the total red yeast Monacolin K content in the total number of red yeast colonies 780cfu / g, coliform was 19MPN / 100g, molds and yeasts for 71cfu / g, cause bacteria were not detected.

[0050] ????: [0050] EXAMPLE ten:

[0051] 1??????????????????????????????,???????_33°C,?????60h ;??????????????; [0051] 1, a usual freeze-drying apparatus for industrial fermentative production of Monascus freeze dehydration, freeze-drying temperature of _33 ° C, the drying time was 60h; Monascus off free water in the freeze-drying;

[0052] 2???????????????????????????,??9kw????????SOkGy??????,?????1. 5min ; [0052] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using 9kw electron accelerator and uses SOkGy sterilizing radiation dose, irradiation time is 1. 5min;

[0053] 3????,???????????????0.85%,????Monacolin K???1180mg/100g,????Monacolin K?????????Monacolin K???96%, Monacolin K?????????????Monacolin K???4%,????????700cfu/g,?????20MPN/100g,??????5kfu/g,??????? [0053] 3, after testing, red yeast rice moisture content after the above approach is 0.85% of the total red yeast Monacolin K content of 1180mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content 96%, Monacolin K lactone structure content is only 4% of the total red yeast Monacolin K content in the total number of red yeast colonies 700cfu / g, coliform was 20MPN / 100g, molds and yeasts for 5kfu / g, cause bacteria were not detected.

Method for keeping stable Monacolin K content in red yeast rice CN 102492748 A

The invention provides a method for keeping stable Monacolin K content in red yeast rice in an industrial production process. The method provided by the invention is a method for adopting freeze drying or vacuum drying and combining electronic accelerator sterilization in the production process of the red yeast rice, so that the Monacolin K content in the red yeast rice and stable proportion and content of an acid type structure and a lactone type structure are effectively kept, and the problem of control over the total number of colonies in a product at normal temperature is effectively solved. The red yeast rice treated by the method provided by the invention has water content of less than 1.2 percent; the total Monacolin K content in red yeast rice is 600-1,200 mg/100 g; the content of the acid type structure of the Monacolin K in red yeast rice accounts for 93-97 percent of the total Monacolin K content; the content of the lactone type structure of the Monacolin K in red yeast rice only accounts for 3-7 percent of the total Monacolin K content; the total number of the colonies in the red yeast rice is less than 1,000 cfu/g; the coli groups are less than 30 MPN/100 g; the mold and the yeast are less than 100 cfu/g; and the pathogen is not detected.

Патентная формула (6) (язык оригинала: китайский )

1. ???????Monacolin K???????,??????????:(1)?????????????????????????????;???????????????-45?-?°C,?????M?60h ;O)????????????????(1)?????????????;???????????4?14kw,?????10?lOOkGy,?????0. 5?5min? A red yeast Monacolin K content in a stable way to keep characterized by specific steps include: (1) freeze-drying apparatus usual industrial production of red yeast fermentation and freeze-dried dehydrated; freeze-drying process conditions require drying temperature To -45

-? ° C, the drying time is M

60h; O), the use of electron accelerators for industrial usually after step (a) dried red yeast irradiation sterilization; using electron accelerator power 4

14kw. exposure dose 10

lOOkGy, the irradiation time is 0. 5

2.??????1?????,?????????????????-38?-32 °C,?????36?48h? 2. The method according to claim 1 or claim 2, wherein the step of freeze-drying temperature ? according to -38

-32 ° C, the drying time is 36

3.??????1?2?????,??????(2)????????1?2min? 3. The method according to claim 1 or claim 2, wherein the step of irradiation time (2) according to 1

4. ???????Monacolin K???????,??????????:(1)?????????????????????????????;???????????????40?65°C,????-550?-780mbar,?????36?72h ;O)????????????????(1)?????????????;???????????4?14kw,?????10?lOOkGy,?????0. 5?5min? 4. A red yeast Monacolin K content in a stable way to keep characterized by specific steps include: (1), using industrial vacuum drying equipment is usually the production of red yeast fermentation vacuum dehydration; vacuum drying process conditions require drying temperature for 40

65 ° C, vacuum degree of -550

-780mbar, drying time is 36

72h; O), the use of electron accelerators for industrial usually by step (1) red yeast rice drying process irradiation sterilization; adopted electron accelerator power 4

14kw, the radiation dose for 10

lOOkGy, irradiation time is 0. 5

5.??????4?????,??????(1)??????????50?55°C, ????-650?-720mbar,?????48?60h? 5. A method according to claim 4, wherein, wherein the vacuum drying temperature in step (1) above is 50

55 ° C, a vacuum degree of -650

-720mbar, drying time 48

6.??????4?5?????,??????(2)????????1?2min? 6. The method according to claim 4 or claim 5, wherein the step of irradiation time (2) according to 1

Описание (язык оригинала: китайский )

???????Monacol in K??????? A method of maintaining red yeast Monacol in K content in a stable way

[0001] ???????????Monacolin?????????????????? [0001] The present invention relates to a red song Monacolin content remains stable in the industrial production process methods. ???? BACKGROUND

[0002] ??????????????????? [0002] has been applied to the traditional red yeast rice as a food coloring and medicinal. ??FDA?1987????????(????,Lovastatin)????? US FDA in 1987 formally approved Mevacor (lovastatin, Lovastatin) for clinical use. ??????Monacolin K(??????)???????????????,??????????????????HMG-CoA???????????????? Natural red yeast in Monacolin K (also known as lovastatin) is red yeast rice has significant physiological activity of substances can inhibit cholesterol biosynthesis pathway, a key enzyme HMG-CoA reductase, which plays the role of lipid-lowering effect. ????Monacolin K???????,?????????????????? Red yeast rice in Monacolin K exists in two forms, namely open-loop and closed-loop structure acid lactone structure. ????,???????????Monacolin K?HMG-CoA????????????,?????????Monaco 1 in K??????,?????????????????????Monacolin K,???????????????,??????????? The study found, Monacolin K acid lactone structure than the structure of HMG-CoA reductase inhibitory effect is more significant, after taking to the lactone structure of Monaco 1 in K of lipid-lowering drugs, the body will produce a carboxyl esterase hydrolyzed to acid structure Monacolin K, this process will result in human liver and kidney burden, adverse effect on some people.

[0003] ????Monacolin K???????????,???????,Monacolin K ????????????????? [0003] Red song structure and acid lactone structure Monacolin K, the difference between a water molecule, acid structure Monacolin K is usually combined with water to form. ????,????????????????????Monacolin K??,?pH?????????????????????,??????????????????????????? The study found that red yeast rice in the industrial manufacturing process, many factors affect Monacolin K content, such as pH, sterilization temperature and time of the production process, the drying temperature and time, and the radiation dose will affect the structure and acid lactone structure The proportion and contents. ??????????????????,??????????????????? Because red yeast Monascus growth and development during the fermentation process, resulting in the total number of colonies than the product of food hygiene standards. ??????????????????,?????????,??Monacolin K?????,????????Monacolin K ????,????????? Commonly used industrial heating temperature and high pressure sterilization method, not only affect the color of products, content and Monacolin K decline, especially Monacolin K proportion dropped acid structure, resulting in decreased product quality. ???????????????,??????????????????????Monacol in K??????,??????????Mcmacol in K? Monascus removed during drying of the free water, but a longer time will inevitably result in a high temperature drying the acid type structure Monacol in K loses its water of hydration, and converted to the lactone structure of Mcmacol in K. ?????-60????????,???????????Monacolin K?????, ????Monacolin K????10%?,????????????????????????? If adopted by the cobalt-60 irradiation sterilization processing Monacolin K content, structure and acid lactone structure were decreased after irradiation Monacolin K content decreased by 10%, and a decrease in acid structure is significantly greater than in the decline ester type structure. ????????????????????????????????-60 ???????,????????????????Monacolin K?????????????? Because red yeast moist heat sterilization in industrial manufacturing processes require sterilization taken, and the high-temperature drying process measures, such as cobalt-60 irradiation, significantly affect the content of red yeast key Monacolin K physiologically active substances to reduce and acid structure conversion.

[0004] ???????????????Monacolin K?????????????????? [0004] The present invention is to provide a Monacolin K content in red yeast stable method in industrial production processes.

[0005] ????????????????????????????????????????????,??????????????Monacolin K??????????????????????? [0005] The method of the invention is the use of freeze-dried or vacuum-dried and combined electron accelerator irradiation sterilization method in red yeast production process, the effective protection of red yeast Monacolin K content and acid structure in industrial processes and the ratio of the content of the lactone structure and stability.

[0006] ????????????: [0006] The specific steps of the method of the present invention comprises:

[0007] (1)??????????????????????????(???)?????????????,??????????;???????????????-45?-?°C,?????M?60h,?????????-38?-32°C,?????36?48h ;???????????????40?65°C,????-550?-780mbar,?????36?72h,??????????50?55°C,????-650?-720mbar,?????48 ?60h ; [0007] (1), the use of industrial drying devices typically freeze-dried or vacuum produced by the fermentation of red yeast (Monascus) freeze-dried or vacuum dehydration, effectively removing MONASCUS free water; freeze-drying process conditions require dry temperature of -45

-? ° C, the drying time is M

60h, the optimum temperature was lyophilized to -38

-32 ° C, the drying time is 36

48h; vacuum drying process conditions require a drying temperature of 40

65 ° C, vacuum degree of -550

-780mbar, the drying time is 36

72h, the optimal temperature of the vacuum drying 50

55 ° C, a vacuum degree of -650

-720mbar, the drying time is 48

[0008] O)????????????????(1)?????????????,?????????????????;???????????4?14kw,?????10? lOOkGy,?????0. 5?5min ;???????1?anin? [0008] O), the use of electron accelerators for industrial usually after step (a) dried red yeast irradiation sterilization, so that red yeast microbial indicators in line with food hygiene standards; using electron accelerator power 4

14kw, spoke Dose for 10

lOOkGy, irradiation time is 0. 5

5min; optimal exposure time for 1

[0009] ???,??????????????,???????1.2%,????Monacolin K???600?1200mg/100g,????Monacolin K?????????Monacolin K???93?97 %,????Monacolin K?????????????Monacolin K???3?7% ;?????????1000cfu/g,??????30MPN/100g, ???????lOOcfu/g,??????? [0009] After testing, the above-mentioned process of the invention after the red yeast rice, the moisture content of less than 1.2% of the total red yeast Monacolin K content 600

1200mg / 100g, the acid content of red yeast rice in the structure of Monacolin K 93

97% Monacolin K content of the total of red yeast Monacolin K lactone structure content only 3

7% of the total red yeast Monacolin K content; red yeast is less than the total number of colonies 1000cfu / g, coliform group below 30MPN / 100g, molds and yeasts less than lOOcfu / g, pathogen not detected.

[0010] ???????????????????????????,????????????,??????????????Monacolin K????????????,???????????Monacolin K??????????????????????????,????????????????????,????????Monacolin K??????????? [0010] The present invention by freeze-drying or vacuum drying process removed MONASCUS free water, combined with electron accelerator radiation processing, not only in the industrial production process so that the red yeast Monacolin K content and acid content which does not fall. and avoid its Monacolin K acid structure extended period of time high-temperature drying process loses its water of hydration is converted into a lactone structure, and an effective solution at room temperature, the total number of products in the control colonies, obtained with a high content of Monacolin K acid structure of red yeast rice products.

[0011] ?????????????????????GZLS-75?GZLS-100?GZLS-125 ???????????,???????-55?120°C ;?????????????????5. O?10. OMeV,?????5?30KW????????? [0011] The present invention relates to a freeze-drying apparatus may be used for industrial model GZLS-75, GZLS-100, GZLS-125 Far series of vacuum freeze-drying machine, shelf operating temperature -55

120 ° C; industry involved energy electron accelerator can be used for 5. O

10. OMeV, electron beam irradiation power 5

[0012] ???????????????(%),???????,???????? [0012] The present invention in various percentage content relates (%), except otherwise noted, are weight percentages.

?????? DETAILED DESCRIPTION

[0013] ???????????????????? [0013] below with reference to embodiments of the present invention will be further described in detail.

[0014] ????: [0014] Embodiment 1:

[0015] 1??????????????????????????????,???????_45°C,?????Mh ;??????????????; [0015] 1, a usual freeze-drying apparatus for industrial fermentative production of Monascus freeze dehydration, freeze-drying temperature of _45 ° C, the drying time is Mh; Monascus off free water in the freeze-drying;

[0016] 2????????????????,???????????,??6kw????????25kGy??????,?????aiiin ; [0016] 2, using the usual industrial electron accelerator irradiation sterilization, reduce microbial indicators MONASCUS using 6kw electron accelerator and uses 25kGy sterilizing radiation dose, irradiation time aiiin;

[0017] 3????,???????????????1. 18%,????Monacolin K???1200mg/100g,????Monacolin K?????????Monacolin K???97%, Monacolin K?????????????Monacolin K???3%,????????920cfu/g,?????25MPN/100g,??????75cfu/g,??????? [0017] 3, after testing, red yeast rice moisture content after the above approach is 1.18%, red yeast total Monacolin K content of 1200mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K 97% of the content, Monacolin K lactone structure content only 3% of the total red yeast Monacolin K content in the total number of red yeast colonies 920cfu / g, coliform was 25MPN / 100g, molds and yeasts for 75cfu / g. pathogenic bacteria were not detected.

[0018] ????: [0018] EXAMPLE II:

[0019] 1??????????????????????????????,???????65°C,????-780mbar,?????48h,??????????????; [0019] 1, using the usual vacuum drying apparatus industrial fermentative production of Monascus vacuum dehydration, vacuum drying temperature of 65 ° C, vacuum degree of -780mbar, drying time was 48h, Monascus off and dried in vacuo in go free water;

[0020] 2???????????????????????????,??Skw????????70kGy??????,?????aiiin ; [0020] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using Skw electron accelerator and uses 70kGy sterilizing radiation dose, irradiation time aiiin;

[0021] 3????,???????????????0.98%,????Monacolin K???1000mg/100g,????Monacolin K?????????Monacolin K???95%,Monacolin K?????????????Monacolin K???5%,????????710cfu/g,?????18MPN/100g,??????45cfu/g,??????? [0021] 3, after testing, red yeast rice moisture content after the above approach is 0.98% of the total red yeast Monacolin K content of 1000mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content 95%, Monacolin K lactone structure content only 5% of the total red yeast Monacolin K content in the total number of red yeast colonies 710cfu / g, coliform was 18MPN / 100g, molds and yeasts for 45cfu / g, cause bacteria were not detected.

[0022] ????: [0022] EXAMPLE III:

[0023] 1??????????????????????????????,???????40°C,????-550mbar,?????72h,??????????????; [0023] 1, using the usual industrial vacuum drying device for fermentation of Monascus vacuum dehydration, vacuum drying temperature of 40 ° C, vacuum degree of -550mbar, drying time is 72h, MONASCUS off in a vacuum drying go free water;

[0024] 2???????????????????????????,??14kw????????SOkGy??????,?????2. 5min ; [0024] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using 14kw electron accelerator and uses SOkGy sterilizing radiation dose, irradiation time was 2. 5min;

[0025] 3????,???????????????0.92%,????Monacolin K ???1100mg/100g,????Monacolin K?????????Monacolin K???95. 5%, Monacolin K?????????????Monacolin K???4. 5%,????????320cfu/g,?????12MPN/100g,??????33cfu/g,??????? [0025] 3, after testing, red yeast rice moisture content after the above approach is 0.92% of the total red yeast Monacolin K content of 1100mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content 95. 5%, Monacolin K lactone structure content only red yeast total Monacolin K content of 4.5%, the total number of red yeast colonies 320cfu / g, coliform was 12MPN / 100g, fungi and yeast 33cfu / g, pathogenic bacteria were not detected.

[0026] ????: [0026] EXAMPLE IV:

[0027] 1??????????????????????????????,???????_32°C,?????48h ;??????????????; [0027] 1, a usual freeze-drying apparatus for industrial fermentative production of Monascus freeze dehydration, freeze-drying temperature of _32 ° C, the drying time was 48h; Monascus off free water in the freeze-drying;

[0028] 2???????????????????????????,??4kw????????IOkGy??????,?????5min ; [0028] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using 4kw electron accelerator and uses IOkGy sterilizing radiation dose, irradiation time is 5min;

[0029] 3????,???????????????1.05%,????Monacolin K???750mg/100g,????Monacolin K?????????Monacolin K???96%, Monacolin K?????????????Monacolin K???4%,????????990cfu/g,?????^MPN/100g,??????98cfu/g,??????? [0029] 3, after testing, red yeast rice moisture content after the above approach is 1.05% of the total red yeast Monacolin K content of 750mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content 96%, Monacolin K lactone structure content is only 4% of the total red yeast Monacolin K content in the total number of red yeast colonies 990cfu / g, coliform is ^ MPN / 100g, molds and yeasts for 98cfu / g, pathogen not detected.

[0030] ????: [0030] Embodiment 5:

[0031] 1??????????????????????????????,???????-M°C,?????36h ;??????????????; [0031] 1, a usual freeze-drying apparatus for industrial fermentative production of Monascus freeze dehydration, freeze-drying temperature is - M ° C, the drying time was 36h; Monascus off free water in the freeze-drying;

[0032] 2???????????????????????????,??IOkw????????70kGy??????,?????aiiin ; [0032] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using IOkw electron accelerator and uses 70kGy sterilizing radiation dose, irradiation time aiiin;

[0033] 3????,???????????????1. 10%,????Monacolin K???1100mg/100g,????Monacolin K?????????Monacolin K???94%, Monacolin K?????????????Monacolin K???6%,????????480cfu/g,?????17MPN/100g,??????50cfu/g,??????? [0033] 3, after testing, red yeast rice moisture content after the above approach is 1.10%, red yeast total Monacolin K content of 1100mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K 94% of the content, Monacolin K lactone structure content only 6% of the total red yeast Monacolin K content in the total number of red yeast colonies 480cfu / g, coliform was 17MPN / 100g, molds and yeasts for 50cfu / g. pathogenic bacteria were not detected.

[0034] ????: [0034] EXAMPLE VI:

[0035] 1??????????????????????????????,???????-40°C,?????50h ;??????????????; [0035] 1, using the usual freeze-drying apparatus for industrial fermentation of Monascus dehydrated and freeze-dried, freeze-drying temperature of -40 ° C, the drying time was 50h; MONASCUS off free water in the freeze-dried;

[0036] 2???????????????????????????,??9kw????????SOkGy??????,?????0. 5min ; [0036] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using 9kw electron accelerator and uses SOkGy sterilizing radiation dose, irradiation time is 0. 5min;

[0037] 3????,???????????????0.96%,????Monacolin K???1200mg/100g,????Monacolin K?????????Monacolin K???97%, Monacolin K?????????????Monacolin K???3%,????????900cfu/g,?????27MPN/100g,??????90cfu/g,??????? [0037] 3, after testing, red yeast rice moisture content after the above approach is 0.96%, red yeast total Monacolin K content of 1200mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content 97%, Monacolin K lactone structure content only 3% of the total red yeast Monacolin K content in the total number of red yeast colonies 900cfu / g, coliform was 27MPN / 100g, molds and yeasts for 90cfu / g, cause bacteria were not detected.

[0038] ????:[0039] 1??????????????????????????????,???????^°C,????-650mbar,?????36h,??????????????; [0038] Example VII: [0039] 1, a usual industrial vacuum drying apparatus for the fermentative production of Monascus vacuum dehydration, vacuum drying temperature is ^ ° C, vacuum degree of -650mbar, drying time was 36h, red aspergillosis off free water and dried in a vacuum;

[0040] 2???????????????????????????,??12kw????????75kGy??????,?????3. 5min ; [0040] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using 12kw electron accelerator and uses 75kGy sterilizing radiation dose, irradiation time was 3. 5min;

[0041] 3????,???????????????1. 0%,????Monacolin K???1100mg/100g,????Monacolin K?????????Monacolin K???96. 5%, Monacolin K?????????????Monacolin K???3. 5%,????????360cfu/g,?????14MPN/100g,??????3kfu/g,??????? [0041] 3, after testing, red yeast rice moisture content after the above approach is 1.0%, the total red yeast Monacolin K content of 1100mg / 100g, red yeast rice in acid structure content Monacolin K total Monacolin K 96.5% content, Monacolin K lactone structure content only red yeast total Monacolin K content of 3.5%, the total number of red yeast colonies 360cfu / g, coliform was 14MPN / 100g, molds and yeasts for 3kfu / g, bacteria were not detected.

[0042] ????: [0042] EXAMPLE VIII:

[0043] 1??????????????????????????????,???????50°C,????-720mbar,?????60h,??????????????; [0043] 1, using the usual industrial vacuum drying device for fermentation of Monascus vacuum dehydration, vacuum drying temperature of 50 ° C, vacuum degree of -720mbar, drying time is 60h, MONASCUS off in a vacuum drying go free water;

[0044] 2???????????????????????????,??IOkw????????75kGy??????,?????Imin ; [0044] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using IOkw electron accelerator and uses 75kGy sterilizing radiation dose, irradiation time for Imin;

[0045] 3????,???????????????1. 05%,????MonacolinK???1150mg/100g,????Monacolin K?????????Monacolin K???96. 5%, Monacolin K?????????????Monacolin K???3. 5%,????????860cfu/g,?????24MPN/100g,??????68cfu/g,??????? [0045] 3, after testing, red yeast rice moisture content after the above approach is 1.05%, red yeast total MonacolinK content of 1150mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content of 96. 5%, Monacolin K lactone structure content only red yeast total Monacolin K content of 3.5%, the total number of red yeast colonies 860cfu / g, coliform was 24MPN / 100g, fungi and yeast 68cfu / g, pathogenic bacteria were not detected.

[0046] ????: [0046] EXAMPLE IX:

[0047] 1??????????????????????????????,???????_38°C,?????^h ;??????????????; [0047] 1, a usual freeze-drying apparatus for industrial fermentative production of Monascus freeze dehydration, freeze-drying temperature of _38 ° C, the drying time for ^ h; Monascus off free water in the freeze-drying;

[0048] 2???????????????????????????,??6kw????????IOOkGy??????,?????-in ; [0048] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using 6kw electron accelerator and uses IOOkGy sterilizing radiation dose, irradiation time - in;

[0049] 3????,???????????????0.95%,????Monacolin K???600mg/100g,????Monacolin K?????????Monacolin K???97%, Monacolin K?????????????Monacolin K???3%,????????780cfu/g,?????19MPN/100g,??????71cfu/g,??????? [0049] 3, after testing, red yeast rice moisture content after the above approach is 0.95% of the total red yeast Monacolin K content of 600mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content 97%, Monacolin K lactone structure content only 3% of the total red yeast Monacolin K content in the total number of red yeast colonies 780cfu / g, coliform was 19MPN / 100g, molds and yeasts for 71cfu / g, cause bacteria were not detected.

[0050] ????: [0050] EXAMPLE ten:

[0051] 1??????????????????????????????,???????_33°C,?????60h ;??????????????; [0051] 1, a usual freeze-drying apparatus for industrial fermentative production of Monascus freeze dehydration, freeze-drying temperature of _33 ° C, the drying time was 60h; Monascus off free water in the freeze-drying;

[0052] 2???????????????????????????,??9kw????????SOkGy??????,?????1. 5min ; [0052] 2, using the usual industrial electron accelerator irradiation sterilization to reduce the microbial indicators MONASCUS using 9kw electron accelerator and uses SOkGy sterilizing radiation dose, irradiation time is 1. 5min;

[0053] 3????,???????????????0.85%,????Monacolin K???1180mg/100g,????Monacolin K?????????Monacolin K???96%, Monacolin K?????????????Monacolin K???4%,????????700cfu/g,?????20MPN/100g,??????5kfu/g,??????? [0053] 3, after testing, red yeast rice moisture content after the above approach is 0.85% of the total red yeast Monacolin K content of 1180mg / 100g, acid structure content in red yeast Monacolin K total Monacolin K content 96%, Monacolin K lactone structure content is only 4% of the total red yeast Monacolin K content in the total number of red yeast colonies 700cfu / g, coliform was 20MPN / 100g, molds and yeasts for 5kfu / g, cause bacteria were not detected.



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Lanmer? - Products, Lansiclav

Lanmer?

Meropenem is a carbapenem antibiotic for parenteral use, that is relatively stable to human dehydropeptidase-1 (DHP-1) and therefore, does not require the addition of an inhibitor of DHP-1.

Meropenem exerts its bactericidal action by interfering with vital bacterial cell wall synthesis. The ease with which it penetrates bacterial cell walls, its high level of stability to all serine β-lactamases and its marked affinity for the Penicilline Binding Proteins (PBTs) explain the potent bactericidal action of meropenem against a broad spectrum of aerobic and anaerobic bacteria. Minimum bactericidal concentrations (MBC) are commonly the same as the minimum inhibitory concentrations (MIC). For 76 % of the bacteria tested, the MBC. MIC ratios were 2 or less.

Meropenem is stable in susceptibility tests and these tests can be performed using normal routine methods. In vitro tests show that meropenem acts synergistically with various antibiotics. It has been demonstrated both in vitro and in vivo that meropenem has a post antibiotic effect.

A single set of meropenem susceptibility criteria are recommended based on pharmacokinetics and correlation of clinical and microbiological outcomes with zone diameter and minimum inhibitory concentrations (MIC) of the infecting organisms.

Each vial of 1.28 g dry powder contains 1.28 g Meropenem sodium carbon equivalent to 1 g Meropenem.

Meropenem i. v. is indicated for treatment, in adult and children, of the following infections caused by single or multiple bacteria sensitive to meropenem.

· Pneumonias and Nosocomial Pneumonias

· Urinary tract infections

· Intra-abdominal infections

· Gynaecological infections, such as endometritis

· Skin and Skin Structure infections

Empiric treatment, for presumed infections in adult patients with febrile neutropenia, used as monotherapy or in combination with anti-viral or anti-fungal agents.

Meropenem has proved efficacious alone or in combination with other antimicrobial agents in the treatment of polymicrobial infections. There is no experience in paediatric patients with neutropenia or primary or secondary immunodeficiency.

Meropenem is contraindicated in patients who have demonstrated hypersensitivity to this product.

PRECAUTIONS AND WARNINGS

There is some clinical and laboratory evidence of partial cross-allergenicity between other carbapenems and beta-lactam antibiotics, penicillines and cephalosphorines. Severe reactions (including anaphylaxis) have been reported with most beta-lactam antibiotics. Before initiating therapy with meropenem, careful enquiry should be made concerning previous hypersensitivity reactions to beta-lactam antibiotics. Meropenem should be used with caution in patients with such a history. If an allergic reaction to meropenem occurs, the drug should be discontinued and appropriate measures taken.

Use of meropenem in patients with hepatic disease should be made with careful monitoring of transaminase and bilirubin levels.

As with other antibiotics, overgrowth of non-susceptible organisms may occur and, therefore, continuous monitoring of each patient is necessary.

Use in infections caused by methicillin resistant staphylococcus is not recommended. Rarely, pseudomembranous colitis has been reported on Meropenem as with practically all antibiotics and may vary in severity from slight to life-threatening. Therefore, antibiotics should be prescribed with care for individuals with a history of gastrointestinal complaints, particularly colitis. It is important to consinder the diagnosis of pseudomembranous colitis in the case of patients who develop diarrhoea in association with the use of meropenem. Although studies indicate that a toxin produced by Clostridium difficile is one of the main causes antibiotic-associated colitis, other causes should be considere. The co-administration of meropenem with potentially nephrotoxic drugs should be considered with caution. (For dosage see “Dosage and Administration” ).

Efficacy and tolerability in infants under 3 months old have not been established; therefore, Meropenem is not recommended for use below this age. There is no experience in children with altered hepatic or renal function.

Keep all medicines away from children.

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Senokot Natural Vegetable Laxative - 50 Tablets, Satolax

Senokot Natural Vegetable Laxative -- 50 Tablets

Do not use laxative products for longer than 1 week unless directed by a doctor.

Ask a doctor before use if you have stomach pain; nausea; vomiting; noticed a sudden change in bowel habits that continues over a period of 2 weeks.

Stop use and ask a doctor if you have rectal bleeding or fail to have a bowel movement after use of a laxative. These may indicate a serious condition.

If pregnant or breast-feeding, ask a health professional before use.

In case of accidental overdose, get medical help or contact a Poison Control Center right away.

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SKU #: 367618300503

Shipping Weight: 0.08

Servings: 50



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Warfarin Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Warafin

warfarin

Warnings

Warfarin can cause very serious (possibly fatal) bleeding. This is more likely to occur when you first start taking this medication or if you take too much warfarin.

To decrease your risk for bleeding, your doctor or other health care provider will monitor you closely and check your lab results (INR test) to make sure you are not taking too much warfarin. Keep all medical and laboratory appointments. Tell your doctor right away if you notice any signs of serious bleeding. See also Side Effects section.

Uses

This medication is used to treat blood clots (such as in deep vein thrombosis - DVT or pulmonary embolus-PE) and/or to prevent new clots from forming in your body. Preventing harmful blood clots helps to reduce the risk of a stroke or heart attack. Conditions that increase your risk of developing blood clots include a certain type of irregular heart rhythm (atrial fibrillation ), heart valve replacement, recent heart attack. and certain surgeries (such as hip/knee replacement ).

Warfarin is commonly called a "blood thinner ," but the more correct term is "anticoagulant." It helps to keep blood flowing smoothly in your body by decreasing the amount of certain substances (clotting proteins) in your blood .

How to use warfarin

Read the Medication Guide provided by your pharmacist before you start taking warfarin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor or other health care professional, usually once a day. It is very important to take it exactly as directed. Do not increase the dose, take it more frequently, or stop using it unless directed by your doctor.

Dosage is based on your medical condition, laboratory tests (such as INR), and response to treatment. Your doctor or other health care provider will monitor you closely while you are taking this medication to determine the right dose for you.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

It is important to eat a balanced, consistent diet while taking warfarin. Some foods can affect how warfarin works in your body and may affect your treatment and dose. Avoid sudden large increases or decreases in your intake of foods high in vitamin K (such as broccoli, cauliflower, cabbage, brussels sprouts, kale, spinach, and other green leafy vegetables, liver. green tea. certain vitamin supplements ). If you are trying to lose weight. check with your doctor before you try to go on a diet.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

Side Effects

Nausea. loss of appetite, or stomach /abdominal pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication can cause serious bleeding if it affects your blood clotting proteins too much (shown by unusually high INR lab results). Even if your doctor stops your medication, this risk of bleeding can continue for up to a week. Tell your doctor right away if you have any signs of serious bleeding, including: unusual pain/swelling/discomfort, unusual/easy bruising, prolonged bleeding from cuts or gums, persistent/frequent nosebleeds. unusually heavy/prolonged menstrual flow, pink/dark urine, coughing up blood. vomit that is bloody or looks like coffee grounds, severe headache. dizziness /fainting. unusual or persistent tiredness/weakness. bloody/black/tarry stools, chest pain. shortness of breath, difficulty swallowing.

Tell your doctor right away if any of these unlikely but serious side effects occur: persistent nausea/vomiting. severe stomach /abdominal pain, yellowing eyes /skin.

This drug rarely has caused very serious (possibly fatal) problems if its effects lead to small blood clots (usually at the beginning of treatment). This can lead to severe skin/tissue damage that may require surgery or amputation if left untreated. Patients with certain blood conditions (protein C or S deficiency) may be at greater risk. Get medical help right away if any of these rare but serious side effects occur: painful/red/purplish patches on the skin (such as on the toe, breast. abdomen ), signs of kidney problems (such as change in the amount of urine), vision changes, confusion, slurred speech, weakness on one side of the body.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash, itching /swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking warfarin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood disorders (such as anemia, hemophilia), bleeding problems (such as bleeding of the stomach/intestines, bleeding in the brain), blood vessel disorders (such as aneurysms), recent major injury/surgery, liver disease, alcohol use, mental/mood disorders (including memory problems), frequent falls/injuries.

It is important that all your doctors and dentists know that you take warfarin. Before having surgery or any medical/dental procedures, tell your doctor or dentist that you are taking this medication and about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Avoid getting injections into the muscles. If you must have an injection into a muscle (for example, a flu shot), it should be given in the arm. This way, it will be easier to check for bleeding and/or apply pressure bandages.

This medication may cause stomach bleeding. Daily use of alcohol while using this medicine will increase your risk for stomach bleeding and may also affect how this medication works. Limit alcoholic beverages. Ask your doctor or pharmacist about how much alcohol you may safely drink.

If you have not been eating well, if you have an illness or infection that causes fever, vomiting, or diarrhea for more than 2 days, or if you start using any antibiotic medications, contact your doctor or pharmacist right away because these conditions can affect how warfarin works.

This medication can cause heavy bleeding. To lower the chance of getting cut, bruised, or injured, use great caution with sharp objects like safety razors and nail cutters. Use an electric razor when shaving and a soft toothbrush when brushing your teeth. Avoid activities such as contact sports. If you fall or injure yourself, especially if you hit your head, call your doctor right away. Your doctor may need to check you.

The Food & Drug Administration has stated that generic warfarin products are interchangeable. However, consult your doctor or pharmacist before switching warfarin products. Be careful not to take more than one medication that contains warfarin unless specifically directed by the doctor or health care provider who is monitoring your warfarin treatment.

Older adults may be at greater risk for bleeding while using this drug.

This medication is not recommended for use during pregnancy because of serious (possibly fatal) harm to an unborn baby. Discuss with your doctor the use of reliable forms of birth control while taking this medication and for 1 month after stopping the medication. If you become pregnant or think you may be pregnant, tell your doctor right away. If you are planning pregnancy, discuss a plan for managing your condition with your doctor before you become pregnant. Your doctor may switch the type of medication you use during pregnancy.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

Very small amounts of this medication may pass into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Warfarin interacts with many prescription, nonprescription, vitamin, and herbal products. This includes medications that are applied to the skin or inside the vagina or rectum. The interactions with warfarin usually result in an increase or decrease in the "blood-thinning" (anticoagulant) effect. Your doctor or other health care professional should closely monitor you to prevent serious bleeding or clotting problems. While taking warfarin, it is very important to tell your doctor or pharmacist of any changes in medications, vitamins, or herbal products that you are taking.

Some products that may interact with this drug include: capecitabine, imatinib, mifepristone.

Aspirin, aspirin-like drugs (salicylates), and nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen, naproxen, celecoxib) may have effects similar to warfarin. These drugs may increase the risk of bleeding problems if taken during treatment with warfarin. Carefully check all prescription/nonprescription product labels (including drugs applied to the skin such as pain-relieving creams) since the products may contain NSAIDs or salicylates. Talk to your doctor about using a different medication (such as acetaminophen) to treat pain/fever. Low-dose aspirin and related drugs (such as clopidogrel, ticlopidine) should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention. Consult your doctor or pharmacist for more details.

Many herbal products interact with warfarin. Tell your doctor before taking any herbal products, especially bromelains, coenzyme Q10, danshen, dong quai, fenugreek, garlic, ginkgo biloba, ginseng, and St. John's wort, among others.

This medication may interfere with a certain laboratory test to measure theophylline levels, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: bloody/black/tarry stools, pink/dark urine, unusual/prolonged bleeding.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as INR, complete blood count) must be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

For the best possible benefit, do not miss any doses. If you do miss a dose and remember on the same day, take it as soon as you remember. If you remember on the next day, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up because this could increase your risk for bleeding. Keep a record of missed doses to give to your doctor or pharmacist. Contact your doctor or pharmacist if you miss 2 or more doses in a row.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

Images

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Returning readers will know that seeing two similar cards pop up means just one thing… Crossfire benchmarking! After I finished up my review of the Sapphire RX 470, I stayed up all night benchmarking the two cards together. I wanted to take a look and find out if picking up two RX 470’s would be better than a single GTX 1070, something that falls into the same price range. In addition, I was curious if we would just see an improvement in the 1080p resolution that these cards were designed for or if maybe they would be more viable for 1440p as well when paired up. As always with our SLI and Crossfire testing. I skip all of the normal review stuff and frankly don’t write to much, leaving you guys with a whole pile of graphs and performance numbers to sort through. So enjoy!

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Corporate Info

Exten SA is a Swiss producer of plastic films, laminates and sheets located in the South of Switzerland, close to the Italian Border.

The company is privately owned and was established in 1981,since then Exten has been constantly growing to reach in 2009 a total turnover of Euro 43 Mil, and has around 105 employees.

In 2006 a new division called EX-P. dedicated to the production of PP Sheets, started operations and is producing full capacity.

The combination of the world-famous Swiss precision and attention to detail with the Italian flexibility and creativity makes Exten quite unique and an entity of its own in the market of film and laminate extrusion.

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The company has been ISO 9001 certified since 1993(today ISO 9001-2008) and works according to the most modern and efficient procedures.

Constant focus on product development and versatility of the technology are other assets Exten has that enable the company to propose itself on the market has the most innovative and reliable partner of the filed.

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Anaerobio Medlineplus Enciclopedia Medica, Anerobia

Anaerobio

Para usar las funciones de compartir de esta paginas, por favor, habilite JavaScript.

La palabra anaerobio significa "sin oxigeno". El termino tiene muchos usos en medicina.

Las bacterias anaerobias son microorganismos que son capaces de sobrevivir y multiplicarse en ambientes que no tienen oxigeno. Por ejemplo, pueden proliferar en tejido humano lesionado que no este recibiendo un flujo de sangre rica en oxigeno. Este tipo de bacterias causan infecciones como el tetanos y la gangrena. Las infecciones anaerobias normalmente causan abscesos (acumulacion de pus), y la muerte del tejido. Muchas bacterias anaerobias producen enzimas que destruyen el tejido, y a veces, toxinas poderosas.

Ademas de las bacterias, algunos protozoarios y gusanos tambien son anaerobios.

Las enfermedades que provocan una deficiencia de oxigeno en el cuerpo pueden forzar al cuerpo a utilizar la actividad anaerobica. Esto puede causar la formacion de quimicos nocivos. Puede suceder en todos los tipos de shock .

Anaerobio (anaerobico) es lo contrario de aerobio .

Durante el ejercicio, nuestros cuerpos necesitan llevar a cabo reacciones tanto aerobicas como anaerobicas para suministrarnos energia. Necesitamos reacciones aerobicas para los ejercicios mas lentos y prolongados como caminar o trotar. Las reacciones anaerobicas son mas rapidas. Las necesitamos durante actividades mas cortas y mas intensas como durante un sprint (carrera).

El ejercicio anaerobico lleva a la acumulacion de acido lactico en los tejidos. Necesitamos oxigeno para eliminar el acido lactico. Cuando los velocistas respiran profundamente despues de correr una carrera, estan eliminando el acido lactico suministrando oxigeno a su cuerpo.

Imagenes

Organismo anaerobico

Referencias

Dorland's Online Medical Dictionary. Available at: dorlands. com/def. jsp? id=100004185. Accessed May 27, 2015.

Fort GG. Anaerobic infection. In: Ferri FF, ed. Ferri's Clinical Advisor 2015 . 1st ed. Philadelphia, PA: Elsevier Mosby; 2014:section I.

Lea mas

Actualizado 4/27/2015

Version en ingles revisada por: Frank A. Greco, MD, PhD, Director, Biophysical Laboratory, Edith Nourse Rogers Memorial Hospital, Bedford, MA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A. D.A. M. Editorial team.

Traduccion y localizacion realizada por: DrTango, Inc.

A. D.A. M. Inc. esta acreditada por la URAC, tambien conocido como American Accreditation HealthCare Commission (www. urac. org). La acreditacion de la URAC es un comite auditor independiente para verificar que A. D.A. M. cumple los rigurosos estandares de calidad e integridad. A. D.A. M. es una de las primeras empresas en alcanzar esta tan importante distincion en servicios de salud en la red. Conozca mas sobre la politica editorial. el proceso editorial y la poliza de privacidad de A. D.A. M. A. D.A. M. es tambien uno de los miembros fundadores de la Junta Etica de Salud en Internet (Health Internet Ethics, o Hi-Ethics) y cumple con los principios de la Fundacion de Salud en la Red (Health on the Net Foundation: www. hon. ch).

La informacion aqui contenida no debe utilizarse durante ninguna emergencia medica, ni para el diagnostico o tratamiento de alguna condicion medica. Debe consultarse a un medico con licencia para el diagnostico y tratamiento de todas y cada una de las condiciones medicas. En caso de una emergencia medica, llame al 911. Los enlaces a otros sitios se proporcionan solo con fines de informacion, no significa que se les apruebe. © 1997-2016 A. D.A. M. Inc. La duplicacion para uso comercial debe ser autorizada por escrito por ADAM Health Solutions.



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Buy Solu Paraxin - Chloramphenicol - Online Without Prescriptions, Solu Paraxin

Chloramphenicol (Solu paraxin)

Chloramphenicol is used for treating serious infections caused by certain bacteria. Chloramphenicol is an antibiotic. It works by killing or slowing the growth of sensitive bacteria.

Use Chloramphenicol as directed by your doctor.

Take Chloramphenicol by mouth with or without food.

If you miss a dose of Chloramphenicol, use it as soon as possible. Then use your doses at evenly spaced times as directed by your doctor. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Chloramphenicol.

Store Chloramphenicol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Chloramphenicol out of the reach of children and away from pets.

Do NOT use Chloramphenicol if:

you are allergic to any ingredient in Chloramphenicol

you have previously had serious side effects from Chloramphenicol

you have a low white or red blood cell count or decreased blood platelets

you have a minor infection such as a cold, flu, throat infection, or you are using Chloramphenicol to prevent a bacterial infection

you are taking other medicines that may decrease your bone marrow (eg, cancer chemotherapy); check with your doctor or pharmacist if you are unsure if any of your other medicines may decrease your bone marrow.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Chloramphenicol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have anemia, bone marrow problems, liver disease, or kidney problems.

Some medicines may interact with Chloramphenicol. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin) because side effects, including risk of bleeding, may be increased

Hydantoins (eg, phenytoin) or sulfonylureas (eg, glyburide) because the actions and side effects of these medicines may be increased.

Medicines that may decrease your bone marrow (eg, cancer chemotherapy ) because the risk of serious side effects, such as low blood platelet levels and low white blood cell counts, may be increased; check with your doctor or pharmacist if you are unsure if any of your medicines may decrease your bone marrow.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Chloramphenicol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Do not exceed the recommended dose or use Chloramphenicol for longer than prescribed without checking with your doctor.

Chloramphenicol is effective only against bacteria. It is not effective for treating viral infections (eg, the common cold).

It is important to use Chloramphenicol for the full course of treatment. Failure to do so may decrease the effectiveness of Chloramphenicol and increase the risk that the bacteria will no longer be sensitive to Chloramphenicol and will not be able to be treated by this or certain other antibiotics in the future.

Long-term or repeated use of Chloramphenicol may cause a second infection. Your doctor may want to change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur.

If symptoms of "gray syndrome" (swelling of the abdomen, pale or blue skin color, vomiting, shock, difficulty breathing, refusal to suck, loose green stools, limp muscles, low temperature) occur in a newborn or infant, contact your doctor. Death may occur within hours of the onset of symptoms. Stopping use of Chloramphenicol when symptoms first appear increases the chance for a complete recovery.

Chloramphenicol may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.

Chloramphenicol may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

Diabetes patients - Chloramphenicol may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.

LAB TESTS, including complete blood cell counts, may be performed to monitor your progress or check for side effects. Be sure to keep all doctor and lab appointments.

Use Chloramphenicol with extreme caution in children younger 1 year. Safety and effectiveness in this age group have not been confirmed.

Use Chloramphenicol with extreme caution in children younger 10 years who have diarrhea or a stomach or bowel infection.

Use Chloramphenicol with extreme caution in premature and full-term infants because they may be more sensitive to the effects of Chloramphenicol, especially the risk of "gray syndrome."

Pregnancy and breast-feeding: If you become pregnant while taking Chloramphenicol, discuss with your doctor the benefits and risks of using Chloramphenicol during pregnancy. Chloramphenicol should be used with extreme caution during full-term pregnancy and labor because the fetus may experience severe side effects. Chloramphenicol is excreted in breast milk. Do not breastfeed while taking Chloramphenicol.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Mild diarrhea, nausea, or vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dark urine; delirium; depression; headache; fever, chills, or sore throat; pain, redness, or swelling at the injection site; symptoms of "gray syndrome" in an infant (swelling of the abdomen, pale or blue skin color, vomiting, shock, difficulty breathing, refusal to suck, loose green stools, limp muscles, low temperature); unusual bleeding or bruising; unusual tiredness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Ketorolac Drops Indications, Side Effects, Warnings, Ketomar

Ketorolac drops

Treating itchy eyes caused by seasonal allergies. It may also be used to treat inflammation (eg, redness, swelling, irritation) following cataract surgery. It may also be used for other conditions as determined by your doctor.

Ketorolac drops are a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking the production of prostaglandin, a substance that causes itching and inflammation.

Do NOT use ketorolac drops if:

you are allergic to any ingredient in ketorolac drops

you are in late pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using ketorolac drops:

Some medical conditions may interact with ketorolac drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to aspirin or an NSAID (eg, ibuprofen, naproxen, celecoxib)

if you have other eye problems, have an abnormal cornea or disease affecting the surface of the eye (eg, dry eye syndrome), or you had complicated eye surgery or repeated eye surgery within a short period of time

if you have asthma, bleeding problems, diabetes, nasal polyps, or rheumatoid arthritis

Some MEDICINES MAY INTERACT with ketorolac drops. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, heparin, or NSAIDs (eg, ibuprofen) because the risk of bleeding may be increased

Topical corticosteroids for the eye (eg, dexamethasone) because they may slow or delay the healing of the eye

This may not be a complete list of all interactions that may occur. Ask your health care provider if ketorolac drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use ketorolac drops:

Use ketorolac drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ketorolac drops are only for the eye. Do not get it in your nose or mouth.

To use ketorolac drops in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.

To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.

If you will be using ketorolac drops to treat both eyes after surgery, do not use the same bottle for both eyes. Doing so may increase the risk of passing an infection from one eye to the other.

If you are using other eye medicines, wait at least 5 minutes before applying them to the eye.

Do not wear contact lenses while you are using ketorolac drops. Take care of your contact lenses as directed by the manufacturer. Check with your doctor before you use them.

Do not use ketorolac drops if it is discolored.

If you miss a dose of ketorolac drops and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use ketorolac drops.

Important safety information:

Ketorolac drops may cause blurred vision. Do not drive or perform other possibly unsafe tasks unless you can see clearly.

Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor. Using ketorolac drops more than 24 hours before eye surgery or for more than 14 days after eye surgery may increase the risk of certain eye problems (eg, corneal problems). Some of these could be serious. Talk with your doctor if you have questions.

If your symptoms do not get better within a few days or if they get worse, check with your doctor.

Tell your doctor if you have a tendency to bleed easily.

If you injure your eye, develop an eye infection, or need to have eye surgery, contact your doctor right away. You will need to discuss the continued use of ketorolac drops.

Ketorolac drops should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: Avoid using ketorolac drops late in pregnancy. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using ketorolac drops while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use ketorolac drops, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of ketorolac drops:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Temporary stinging and burning of the eye while applying.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); pain, irritation, redness, swelling, or persistent stinging or burning of the eyes; unusual bleeding; vision changes (eg, blurred vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www. fda. gov/medwatch .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www. aapcc. org ), or emergency room immediately.

Proper storage of ketorolac drops:

Store ketorolac drops at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep ketorolac drops out of the reach of children and away from pets.

General information:

If you have any questions about ketorolac drops, please talk with your doctor, pharmacist, or other health care provider.

Ketorolac drops are to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take ketorolac drops or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about ketorolac drops. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to ketorolac drops. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using ketorolac drops.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about ketorolac ophthalmic



Buy Online Ketorolac Drops Indications, Side Effects, Warnings, Ketomar

Brondilat Para Que Sirve, Brondilat

BRONDILAT

Precaucion con mayores de 15 anos

Revise siempre que no sea alergico a ninguno de los componentes de BRONDILAT . podria poner en peligro su salud

Recuerda antes de tomar este medicamento consultar siempre con su medico, la informacion que ofrecemos es orientativa y no sustituye en ningun caso la de su medico u otro profesional de la salud.

Prospecto e indicaciones

Composicion:

Comprimidos 4 mg:

cada comprimido masticable contiene: Montelukast 4 mg.

Comprimidos 5 mg:

cada comprimido masticable contiene: Montelukast 5 mg.

Comprimidos 10 mg:

cada comprimido recubierto contiene: Montelukast 10 mg.

Indicaciones:

Brondilat esta indicado para la profilaxis y tratamiento del asma bronquial cronica, y para la prevencion del broncoespasmo causado por el ejercicio.

Accion Terapeutica:

Prevencion del asma bronquial (antileucotrienos).

Presentaciones:

Brondilat 4 mg:

envases conteniendo 10 y 30 comprimidos masticables.

Brondilat 5 mg:

envases conteniendo 10 y 30 comprimidos masticables.

Brondilat 10 mg:

envases conteniendo 10 y 30 comprimidos recubiertos.

Posologia:

Adultos y adolescentes mayores de 15 anos:

la dosis recomendada es de 1 comprimido recubierto de 10 mg 1 vez al dia.

Ninos entre 6 y 14 anos:

la dosis recomendada es de 1 comprimido masticable de 5 mg 1 vez al dia.

Ninos entre 2 y 6 anos:

la dosis recomendada es de 1 comprimido masticable de 4 mg 1 vez al dia.



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Wincocef, Wincocef

Cefadroxil fights bacteria in the body. Cefadroxil is used to treat many different types of bacterial infections such as bronchitis, tonsillitis, ear infections, skin infections, and urinary tract infections.

Use Cefadroxil as directed by your doctor.

Take Cefadroxil by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. To clear up your infection completely, take Cefadroxil for the full course of treatment. Keep taking it even if you feel better in a few days. Ask your health care provider any questions you may have about how to use Cefadroxil. Drug Class and Mechanism

Cefadroxil is a cephalosporin antibiotic. It works by interfering with the bacteria's cell wall formation. This weakens the cell wall, causing it to rupture, resulting in death of the bacteria.

If you miss a dose of Cefadroxil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Cefadroxil at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Cefadroxil out of the reach of children and away from pets.

Do not use Cefadroxil if:

if you are pregnant, planning to become pregnant, or are breast-feeding; if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement; if you have allergies to medicines, foods, or other substances; if you have a blood clotting disorder, kidney problems, or stomach or bowel problems (e. g. inflammation); if you have had a severe allergic reaction (e. g. a severe rash, hives, breathing difficulties, or dizziness) to a penicillin antibiotic (e. g. amoxicillin) or other beta-lactam antibiotic (e. g. imipenem). Contact your doctor or health care provider right away if any of these apply to you.

Important : Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor. Be sure to use Cefadroxil for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. Cefadroxil only works against bacteria; it does not treat viral infections (e. g. the common cold). Long-term or repeated use of Cefadroxil may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this. Diabetes patients - Cefadroxil may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine. Cefadroxil may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Cefadroxil. Pregnancy and breast-feeding: if you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cefadroxil while you are pregnant. Cefadroxil is found in breast milk. If you are or will be breast-feeding while you use Cefadroxil. check with your doctor. Discuss any possible risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

diarrhea; nausea; stomach upset; vomiting. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; dark urine; decreased urination; fever, chills, or sore throat; joint pain; red, swollen, or blistered skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; unusual tiredness or weakness; vaginal itching, odor, or discharge; yellowing of the skin or eyes. More Information

Cefadroxil is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

Cefadroxil fights bacteria in the body. Cefadroxil is used to treat many different types of bacterial infections such as bronchitis, tonsillitis, ear infections, skin infections, and urinary tract infections.

Use Cefadroxil as directed by your doctor.

Take Cefadroxil by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. To clear up your infection completely, take Cefadroxil for the full course of treatment. Keep taking it even if you feel better in a few days. Ask your health care provider any questions you may have about how to use Cefadroxil. Drug Class and Mechanism

Cefadroxil is a cephalosporin antibiotic. It works by interfering with the bacteria's cell wall formation. This weakens the cell wall, causing it to rupture, resulting in death of the bacteria.

If you miss a dose of Cefadroxil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Cefadroxil at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Cefadroxil out of the reach of children and away from pets.

Do not use Cefadroxil if:

if you are pregnant, planning to become pregnant, or are breast-feeding; if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement; if you have allergies to medicines, foods, or other substances; if you have a blood clotting disorder, kidney problems, or stomach or bowel problems (e. g. inflammation); if you have had a severe allergic reaction (e. g. a severe rash, hives, breathing difficulties, or dizziness) to a penicillin antibiotic (e. g. amoxicillin) or other beta-lactam antibiotic (e. g. imipenem). Contact your doctor or health care provider right away if any of these apply to you.

Important : Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor. Be sure to use Cefadroxil for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. Cefadroxil only works against bacteria; it does not treat viral infections (e. g. the common cold). Long-term or repeated use of Cefadroxil may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this. Diabetes patients - Cefadroxil may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine. Cefadroxil may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Cefadroxil. Pregnancy and breast-feeding: if you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cefadroxil while you are pregnant. Cefadroxil is found in breast milk. If you are or will be breast-feeding while you use Cefadroxil. check with your doctor. Discuss any possible risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

diarrhea; nausea; stomach upset; vomiting. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; dark urine; decreased urination; fever, chills, or sore throat; joint pain; red, swollen, or blistered skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; unusual tiredness or weakness; vaginal itching, odor, or discharge; yellowing of the skin or eyes. More Information

Cefadroxil is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.



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Levlen - Birth Control, Femseptcombi

Birth Control - Femseptcombi (Brand name: levlen)

Levlen is used for preventing pregnancy. Levlen is a combination birth control pill. It works by preventing ovulation, altering the cervical mucus, and changing the lining of the uterus.

Use Levlen as directed by your doctor. Take Levlen by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Begin taking Levlen on the first Sunday following the start of your period, unless otherwise directed by your doctor. If your period begins on a Sunday, begin taking Levlen on that day. Try to take Levlen at the same time every day, not more than 24 hours apart. After taking the last pill in the pack, start taking the first pill from a new pack the very next day. For Levlen to be effective it must be taken every day. Do not skip doses. If you miss a dose of Levlen and remember it on the same day, take it as soon as possible and go back to your regular dosing schedule. If you do not remember until the next day or if you miss more than 1 dose of Levlen, contact your doctor for further instructions. You may need to use an extra form of birth control (eg, condoms). If you are not sure about how to handle missed doses of Levlen, use an extra form of birth control (eg, condoms) until you talk with your doctor.

Ask your health care provider any questions you may have about how to use Levlen.

Store Levlen at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Levlen out of the reach of children and away from pets.

Active Ingredients: Levonorgestrel and Ethinyl Estradiol.

Do NOT use Levlen if: you are allergic to any ingredient in Levlen you are pregnant or think you may be pregnant you have a history of blood clotting problems, severe blood clots (eg, in the lungs, legs, eyes), certain blood vessel problems (eg, bleeding in the brain, heart attack, stroke), or breast cancer you are at risk for developing severe blood clots or have certain heart problems (eg, certain heart valve problems, certain types of irregular heartbeat) you have chest pain caused by angina; certain types of headaches or migraines with aura; severe or uncontrolled high blood pressure; endometrial, cervical, or vaginal cancer; estrogen-dependent growths; or undiagnosed abnormal vaginal bleeding; or diabetes that affects circulation you have liver disease, liver tumors or cancer, or a history of yellowing of the eyes or skin caused by pregnancy or prior birth control use you have had surgery and are or will be confined to a bed or a chair for an extended period of time you are older than 35 years old and you smoke 15 or more cigarettes per day.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Levlen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have endometriosis, growths in the uterus, abnormal mammogram, irregular menstrual periods, a lump in the breast, heart problems, diabetes, headaches or migraines, gallbladder problems, high blood cholesterol or lipid levels, high blood pressure, kidney problems, blood problems (eg, porphyria), blood in the urine, depression or other mental/mood problems, lupus, chorea, high blood calcium levels, yellowing of the eyes or skin, pancreas problems (eg, pancreatitis), seizures (eg, epilepsy), or a history of cancer if you are overweight, you have not yet had your first menstrual period, or you use tobacco if you have given birth or otherwise ended a pregnancy within the past 4 weeks.

Some medicines may interact with Levlen. Tell your health care provider if you are taking any other medicines, especially any of the following: Atorvastatin, indinavir, or troleandomycin because they may increase the risk of Levlen's side effects Aprepitant, azole antifungals (eg, itraconazole, ketoconazole), barbiturates (eg, phenobarbital), bosentan, carbamazepine, dexamethasone, felbamate, griseofulvin, HIV protease inhibitors (eg, ritonavir), hydantoins (eg, phenytoin), modafinil, nevirapine, oxcarbazepine, penicillins (eg, amoxicillin), phenylbutazone, primidone, rifabutin, rifampin, St. John's wort, tetracyclines (eg, doxycycline), topiramate, or troglitazone because they may decrease Levlen's effectiveness, resulting in breakthrough bleeding or pregnancy Beta-blockers (eg, propranolol), corticosteroids (eg, prednisolone), cyclosporine, or theophylline because the risk of their side effects may be increased by Levlen Clofibric acid, lamotrigine, morphine, salicylic acid, or temazepam because their effectiveness may be decreased by Levlen.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Levlen may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information: Levlen may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Levlen with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately. If you will be having surgery or will be confined to a bed or chair for a long period of time (such as a long plane flight), notify your doctor 3 to 4 weeks ahead of time. Special precautions may need to be taken in these circumstances while taking Levlen. You should usually not take Levlen within 4 weeks after giving birth or otherwise ending a pregnancy. Discuss any questions or concerns with your doctor. Levlen may cause dark skin patches on your face. Exposure to the sun may make these patches darker. If patches develop, use a sunscreen or wear protective clothing when exposed to the sun, sunlamps, or tanning booths. Use of Levlen will not protect against HIV infection or prevent the spread of sexually transmitted diseases (STDs). Bleeding or spotting may occur while taking Levlen. Do not stop taking Levlen if this occurs. If bleeding or spotting continues for more than 7 days or is heavy, contact your doctor. Smoking while using Levlen may increase your risk of stroke, heart attack, blood clots, high blood pressure, or other diseases of the heart and blood vessels. Levlen may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Levlen. Taking certain antibiotics, anticonvulsants, or other medicines, as listed in the interactions section, while you are using Levlen may decrease the effectiveness of Levlen. To prevent pregnancy, use an extra form of birth control (eg, condoms) until your next period. If you wear contact lenses and you develop problems with them, contact your doctor. If you miss your period during the week of inactive pills, call your doctor immediately. A missed period may indicate that you are pregnant. Levlen may take time to wear off after your last dose. You may not be able to become pregnant for several months after stopping Levlen. Discuss any concerns with your doctor or pharmacist. Lab tests, such as PAP tests, may be performed while you use Levlen. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Levlen should not be used in children who have not had their first menstrual period; safety and effectiveness in these children have not been confirmed. Pregnancy and breast-feeding: Do not use Levlen if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Levlen is found in breast milk. Do not breastfeed while taking Levlen.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; breast tenderness or enlargement; changes in appetite; changes in sexual interest; changes in weight; dizziness; hair loss; headache; nausea; stomach cramps or bloating; unusual spotting or bleeding; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast discharge; breast lumps; calf or leg pain, swelling, or tenderness; change in amount of urine produced; change in vaginal secretions; changes in vision or speech; confusion; coughing of blood; crushing chest pain or heaviness in the chest; dark-colored urine; depression; difficulty sleeping; difficulty wearing contact lenses; fainting; fluid retention (swelling of the fingers and ankles); lack of energy; light-colored bowel movements; mental or mood changes; missed menstrual period; numbness of an arm or leg; one-sided weakness; persistent headache or migraines; persistent or recurrent abnormal vaginal bleeding; persistent or severe dizziness; severe pain or tenderness in the stomach; shortness of breath; sudden partial or complete loss of vision; sudden severe headache or vomiting; tiredness; vaginal irritation or discharge; weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Levlen is used for preventing pregnancy. Levlen is a combination birth control pill. It works by preventing ovulation, altering the cervical mucus, and changing the lining of the uterus.

Use Levlen as directed by your doctor. Take Levlen by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Begin taking Levlen on the first Sunday following the start of your period, unless otherwise directed by your doctor. If your period begins on a Sunday, begin taking Levlen on that day. Try to take Levlen at the same time every day, not more than 24 hours apart. After taking the last pill in the pack, start taking the first pill from a new pack the very next day. For Levlen to be effective it must be taken every day. Do not skip doses. If you miss a dose of Levlen and remember it on the same day, take it as soon as possible and go back to your regular dosing schedule. If you do not remember until the next day or if you miss more than 1 dose of Levlen, contact your doctor for further instructions. You may need to use an extra form of birth control (eg, condoms). If you are not sure about how to handle missed doses of Levlen, use an extra form of birth control (eg, condoms) until you talk with your doctor.

Ask your health care provider any questions you may have about how to use Levlen.

Store Levlen at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Levlen out of the reach of children and away from pets.

Active Ingredients: Levonorgestrel and Ethinyl Estradiol.

Do NOT use Levlen if: you are allergic to any ingredient in Levlen you are pregnant or think you may be pregnant you have a history of blood clotting problems, severe blood clots (eg, in the lungs, legs, eyes), certain blood vessel problems (eg, bleeding in the brain, heart attack, stroke), or breast cancer you are at risk for developing severe blood clots or have certain heart problems (eg, certain heart valve problems, certain types of irregular heartbeat) you have chest pain caused by angina; certain types of headaches or migraines with aura; severe or uncontrolled high blood pressure; endometrial, cervical, or vaginal cancer; estrogen-dependent growths; or undiagnosed abnormal vaginal bleeding; or diabetes that affects circulation you have liver disease, liver tumors or cancer, or a history of yellowing of the eyes or skin caused by pregnancy or prior birth control use you have had surgery and are or will be confined to a bed or a chair for an extended period of time you are older than 35 years old and you smoke 15 or more cigarettes per day.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Levlen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have endometriosis, growths in the uterus, abnormal mammogram, irregular menstrual periods, a lump in the breast, heart problems, diabetes, headaches or migraines, gallbladder problems, high blood cholesterol or lipid levels, high blood pressure, kidney problems, blood problems (eg, porphyria), blood in the urine, depression or other mental/mood problems, lupus, chorea, high blood calcium levels, yellowing of the eyes or skin, pancreas problems (eg, pancreatitis), seizures (eg, epilepsy), or a history of cancer if you are overweight, you have not yet had your first menstrual period, or you use tobacco if you have given birth or otherwise ended a pregnancy within the past 4 weeks.

Some medicines may interact with Levlen. Tell your health care provider if you are taking any other medicines, especially any of the following: Atorvastatin, indinavir, or troleandomycin because they may increase the risk of Levlen's side effects Aprepitant, azole antifungals (eg, itraconazole, ketoconazole), barbiturates (eg, phenobarbital), bosentan, carbamazepine, dexamethasone, felbamate, griseofulvin, HIV protease inhibitors (eg, ritonavir), hydantoins (eg, phenytoin), modafinil, nevirapine, oxcarbazepine, penicillins (eg, amoxicillin), phenylbutazone, primidone, rifabutin, rifampin, St. John's wort, tetracyclines (eg, doxycycline), topiramate, or troglitazone because they may decrease Levlen's effectiveness, resulting in breakthrough bleeding or pregnancy Beta-blockers (eg, propranolol), corticosteroids (eg, prednisolone), cyclosporine, or theophylline because the risk of their side effects may be increased by Levlen Clofibric acid, lamotrigine, morphine, salicylic acid, or temazepam because their effectiveness may be decreased by Levlen.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Levlen may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information: Levlen may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Levlen with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately. If you will be having surgery or will be confined to a bed or chair for a long period of time (such as a long plane flight), notify your doctor 3 to 4 weeks ahead of time. Special precautions may need to be taken in these circumstances while taking Levlen. You should usually not take Levlen within 4 weeks after giving birth or otherwise ending a pregnancy. Discuss any questions or concerns with your doctor. Levlen may cause dark skin patches on your face. Exposure to the sun may make these patches darker. If patches develop, use a sunscreen or wear protective clothing when exposed to the sun, sunlamps, or tanning booths. Use of Levlen will not protect against HIV infection or prevent the spread of sexually transmitted diseases (STDs). Bleeding or spotting may occur while taking Levlen. Do not stop taking Levlen if this occurs. If bleeding or spotting continues for more than 7 days or is heavy, contact your doctor. Smoking while using Levlen may increase your risk of stroke, heart attack, blood clots, high blood pressure, or other diseases of the heart and blood vessels. Levlen may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Levlen. Taking certain antibiotics, anticonvulsants, or other medicines, as listed in the interactions section, while you are using Levlen may decrease the effectiveness of Levlen. To prevent pregnancy, use an extra form of birth control (eg, condoms) until your next period. If you wear contact lenses and you develop problems with them, contact your doctor. If you miss your period during the week of inactive pills, call your doctor immediately. A missed period may indicate that you are pregnant. Levlen may take time to wear off after your last dose. You may not be able to become pregnant for several months after stopping Levlen. Discuss any concerns with your doctor or pharmacist. Lab tests, such as PAP tests, may be performed while you use Levlen. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Levlen should not be used in children who have not had their first menstrual period; safety and effectiveness in these children have not been confirmed. Pregnancy and breast-feeding: Do not use Levlen if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Levlen is found in breast milk. Do not breastfeed while taking Levlen.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; breast tenderness or enlargement; changes in appetite; changes in sexual interest; changes in weight; dizziness; hair loss; headache; nausea; stomach cramps or bloating; unusual spotting or bleeding; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast discharge; breast lumps; calf or leg pain, swelling, or tenderness; change in amount of urine produced; change in vaginal secretions; changes in vision or speech; confusion; coughing of blood; crushing chest pain or heaviness in the chest; dark-colored urine; depression; difficulty sleeping; difficulty wearing contact lenses; fainting; fluid retention (swelling of the fingers and ankles); lack of energy; light-colored bowel movements; mental or mood changes; missed menstrual period; numbness of an arm or leg; one-sided weakness; persistent headache or migraines; persistent or recurrent abnormal vaginal bleeding; persistent or severe dizziness; severe pain or tenderness in the stomach; shortness of breath; sudden partial or complete loss of vision; sudden severe headache or vomiting; tiredness; vaginal irritation or discharge; weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Drugs And Medications - Supirocin Ointment, Supirocin

Mupirocin USP 2%

Water soluble base q. s.

DESCRIPTION White semi-solid ointment packed in aluminium tubes or plastic jar.

PHARMACOLOGY Mechanism of action Mupirocin (pseudomonic acid; pseudomonic acid A) is an antibiotic produced by submerged fermentation of Pseudomonas fluorescens and is structurally unrelated to other antibiotics. Other substances produced by Pseudomonas fluorescens which are being investigated for antibacterial activity include pseudomonic acids B, C, and D. However, mupirocin appears to have the most antibacterial activity. Pseudomonic acids B, C, and D are generally 2 to 4-fold less active than pseudomonic acid A (mupirocin).

The mechanism of action of mupirocin is unique in that it reversibly and specifically binds to bacterial isoleucyl transfer-RNA synthetase resulting in arrest of protein synthesis, a mechanism dissimilar from any other antibiotic, and inhibiting RNA synthesis. This mechanism of action presumably accounts for the slow rate of emergence of mupirocinresistant staphylococci observed in in vitro studies and lack of cross-resistance with other topical antibiotics. The drug has been active against multi-resistant strains of Staphylococcus aureus and coagulase-negative staphylococci . including strains resistant to penicillin, methicillin, neomycin, erythromycin, fusidic acid, lincomycin, chloramphenicol, tetracycline and gentamicin.

Mupirocin enters cells by passive diffusion. The concentration of mupirocin in sensitive bacteria is dependent upon binding sites on isoleucyl-tRNA synthetase. Resistance to mupirocin involve restricted access to the binding site on isoleucyl-tRNA synthetase as opposed to changes in the cell membrane.

Mupirocin is used for the topical treatment of impetigo due to Staphylococcus aureus; Group A beta-hemolytic Streptococcus . and Streptococcus pyogenes .

Antimicrobial spectrum Based on in vitro studies, mupirocin has a broad range of antibacterial activity. Grampositive bacteria sensitive to mupirocin include Staphylococcus aureus (including methicillin-resistant and beta-lactamase producing), Staphylococcus epidermis, Staphylococcus saprophyticus, and Streptococcus pyogenes. Gram-negative bacteria sensitive to mupirocin include H influenzae, N gonorrhoeae, N meningitidis, Bordetella pertussis, Pasteurella multocida and M catarrhalis (Minimum inhibitory concentration (MIC) less than or equal to 0.25 mg/L). The drug has also been active in vitro against methicillinresistant S. aureus that is resistant to gentamicin.

Mupirocin is bactericidal at concentrations achieved by topical administration. However, the minimum bactericidal concentration (MBC) against relevant pathogens is generally eightfold to thirty-fold higher than the minimum inhibitory concentration (MIC). In addition, mupirocin is highly protein bound (>97%), and the effect of wound secretions on the MICs of mupirocin has not been determined.

Resistance occurs rarely. However, when mupirocin resistance does occur, it appears to result from the production of a modified isoleucyl-tRNA synthetase. High-level plasmidmediated resistance (MIC >1024 mcg/mL) has been reported in some strains of S. aureus and coagulase-negative staphylococci. Due to this unique mode of action, mupirocin demonstrates no in vitro cross-resistance with other classes of antimicrobial agents.

Pharmacokinetics The bioavailability of a topical mupirocin formulation is very low (0.24%). Penetration of mupirocin is enhanced if occlusive dressing is used or if mupirocin is applied to damaged or diseased skin. Measurable radioactivity was present in the stratum corneum of these subjects 72 hours after application. Mupirocin is slowly metabolized in the skin to an inactive metabolite, monic acid. Only 2.7% of mupirocin is metabolized in 48 hours in homogenates of human skin.

INDICATIONS Supirocin Ointment is indicated for the bacterial skin infections e. g: impetigo, folliculitis and furunculitis.

CONTRAINDICATIONS Hypersensitivity to mupirocin or to any components in the formulation.

SIDE EFFECTS/ ADVERSE REACTIONS Adverse reactions are listed below by system organ class and frequency. Frequencies are defined as: very common (1/10), common (1/100, <1/10), uncommon (1/1000, <1/100), rare (1/10,000, <1/1000), very rare (<1/10,000), including isolated reports. Very rare adverse reactions were primarily determined from post-marketing experience data and therefore refer to reporting rate rather than true frequency.

Skin and subcutaneous tissue disorders: Common: Burning localised to the area of application. Uncommon: Itching, erythema, stinging and dryness localised to the area of application. Uncommon: Cutaneous sensitisation reactions to mupirocin or the ointment base.

Immune system disorders: Very rare: Systemic allergic reactions have been reported with Mupirocin Ointment.

PRECAUTIONS / WARNINGS ? Formulations containing polyethylene glycol should not be applied to broken skin or mucus membranes, extensive open wounds or to burns. ? Formulations containing polyethylene glycol should not be used in patients with moderate or severe renal impairment; absorption of polyethylene glycol is possible. ? Avoid contact with eyes. ? As with other antibacterial products, prolonged use may result in overgrowth of non susceptible organisms, including fungi.

DRUG INTERACTION The effect of the concurrent application of Mupirocin ointment and other drug products has not been studied.

USE IN PREGNANCY AND LACTATION

Pregnancy Pregnancy Category B Animal studies using doses that exceed the recommended human dose demonstrated that mupirocin is not teratogenic. However, there are no well-controlled studies in pregnant women. Animal teratogenicity studies are not always predictive of human response. Mupirocin should be used during pregnancy only if the drug is clearly needed.

Lactation It is unknown if mupirocin is excreted in human milk; caution should be used when mupirocin is administered to a nursing woman.

RECOMMENDED DOSAGE, DOSAGE SCHEDULE AND ROUTE OF ADMINISTRATION Adults and children: Supirocin Ointment should be applied to the affected area up to three times daily, for up to 10 days. The area may be covered with a dressing or occluded if desired.

Route of administration. Topical

SYMPTOMS AND TREATMENT FOR OVERDOSAGE AND ANTIDOTE (S) No overdosage has been reported with mupirocin ointment. Since systemic absorption of mupirocin ointment is very low, overdosage is less likely with mupirocin ointment.

PRESENTATION 5g and 15g tube 50g jar pack

SHELF LIFE 24 months

STORAGE CONDITIONS, USER INSTRUCTIONS AND PHARMACEUTICAL PRECAUTIONS Store below 25?C. Do not freeze.



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Dexamethasone - Side Effects, Dosage, Interactions, Dexafort

Dexamethasone

Dexamethasone is the generic form of the brand-name drug Decadron, which works on the immune system to help reduce itching, swelling, and inflammation.

It's used to treat a variety of health conditions, including allergies. arthritis, problems with blood or bone marrow, skin problems, and flare-ups of multiple sclerosis (MS ).

Dexamethasone is a corticosteroid. a class of steroid hormone. The Food and Drug Administration (FDA) approved Decadron in 1958. At that time, Merck & Company made the drug.

Now, several manufacturers offer dexamethasone under various brand names and formulations, including Decadron, Ozurdex, Maxidex, and Baycadron.

It's available to be taken orally or as an intravenous (IV) injection. It also comes in topical skin cream and eye drop forms.

Dexamethasone for Dogs and Cats

Veterinarians prescribe dexamethasone for dogs and cats when they need to treat immune system problems such as asthma, hives, itching, inflammation, and skin and eye problems.

Intravenous (IV) dexamethasone is approved for use in cattle and horses.

Dexamethasone Warnings

Your doctor will not prescribe dexamethasone if you have a fungal infection anywhere in your body since the medicine may worsen the infection.

If you are allergic to dexamethasone, you need to alert your doctor.

While taking this medicine, do not get any vaccines without your doctor's permission. The medicine may affect the way the vaccine works.

If someone in your household has had a live virus vaccine (measles. mumps, nasal flu vaccine ), you should avoid contact with them while taking Decadron. Ask your doctor for details.

Pregnancy and Dexamethasone

Decadron may harm a developing fetus.

You and your doctor will need to determine if the benefits of taking Decadron outweigh the potential risks.

If you become pregnant while taking Decadron, contact your doctor right away.

Corticosteroids appear in breast milk and could hamper a baby’s growth or cause other unwanted side effects.

If you are taking Decadron, your doctor will advise you not to breastfeed.

Using dexamethasone with certain medicines is not recommended.

Your doctor may decide to change these other medicines or avoid treating you with dexamethasone. These include:

Artemether with lumefantine (Coartem), an antimalarial drug

Praziquantel (Biltridice) for parasitic infections

Rilpivirine (Edurant) for HIV

Live rotavirus vaccine

Dexamethasone may also interact with drugs that are used to treat depression and infection.

If you are on any of the following medications, your doctor may change the dose of one or both or change how often you take them:

Bupropion (Wellbutrin, Zyban, others), an antidepressant

Clarithromycin (Biaxin), an antibiotic

Itraconazole (Onmel, Sporanox), an anti-fungal medicine

Telaprevir (Incivek), for hepatitis C infections

If you are on any antidiabetic drugs, your doctor may need to adjust the doses because the steroids may increase blood sugar concentrations.

If you are on the blood thinner warfarin (Coumadin), your response to warfarin may decline. Your doctor may need to monitor you more often.

Using aspirin or similar pain medication while taking dexamethasone may increase your risk of gastrointestinal effects. Ask your doctor about whether you can take both together.

Be sure to tell your doctor about any prescription, non-prescription, over-the-counter (OTC), illegal and recreational drugs, herbal remedies, nutritional and dietary supplements you’re taking before taking dexamethasone.

Dexamethasone Dosage

Doses of dexamethasone in eye drop, cream and other forms differ from patient to patient and depend on the condition being treated.

For oral forms, strengths range from 0.5 milligrams (mg) to 6 mg per tablet.

The prescribed dose depends on the medical condition. In general, dosage for oral solutions and tablets are:

For adults: 0.75 to 9 mg a day, adjusted as needed.

For children: 0.02 to 0.3 mg per kilogram (2.2 pounds) of body weight a day, spread out throughout the day.

The dose for intravenous and intramuscular injections ranges from 0.5 to 9 mg daily, but can be higher or lower.

Dexamethasone Overdose

If you think you have taken too much dexamethasone, contact your doctor or go to the nearest emergency room.

Missed Dose of Dexamethasone

If you skip a dose of dexamethasone, and take the medicine once a day, take the missed dose as soon as you realize you missed it.

However, if it is nearly time for your next dose, resume your regular schedule and don't double up.



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Bactrim wird zur Behandlung von Infektionen, die durch bestimmte Bakterien verursacht wurden. Bactrim ist ein Antibiotikum Kombination von Sulfonamid-Antibiotikum. Es funktioniert durch das Toten von empfindlichen Bakterien.

Verwenden Sie Bactrim, wie von Ihrem Arzt verordnet wurde.

Nehmen Bactrim durch den Mund mit oder ohne Nahrung.

Bactrim funktioniert am besten, wenn sie zur gleichen Zeit jeden Tag genommen wird.

Nehmen Sie Bactrim mit einem vollen Glas Wasser (8 oz/240 mL). Trinken extra Flussigkeiten wahrend der Einnahme Bactrim wird empfohlen. Fragen Sie Ihren Arzt fur Anweisungen.

Zur Klarung Ihrer Infektion vollstandig nehmen Bactrim fur das gesamte Verlauf der Behandlung. Halten Sie dabei, selbst wenn Sie sich besser in ein paar Tagen zu spuren.

Wenn Sie eine Dosis von Bactrim, bringen Sie es so bald wie moglich. Wenn es fast Zeit fur Ihre nachste Dosis ist, uberspringen Sie die vergessene Dosis und gehen Sie zuruck zu Ihrem regelma?igen Dosierungsschema. Nehmen Sie nicht 2 Dosen auf einmal.

Fragen Sie Ihren Arzt Fragen konnen Sie sich daruber, wie Sie Bactrim verwenden haben kann.

Shop Bactrim bei Raumtemperatur zwischen 59 und 77 Grad F (15 und 25 Grad C). Lager weg von der Hitze, Feuchtigkeit und Licht. Halten Sie in einem engen, Licht-Behaltnis. Nicht im Bad. Halten Sie Bactrim au?erhalb der Reichweite von Kindern und weg von Haustieren.

Wirkstoffe: Sulfamethoxazol und Trimethoprim.

Verwenden Sie KEINE Bactrim, wenn:

Sie sind allergisch gegen jegliche Zutaten in Bactrim oder ahnlichen Arzneimitteln

Sie hatte eine schwere allergische Reaktion auf jede andere Sulfonamid (Sulfa) Medizin (zB, Glipizid, Hydrochlorothiazid)

Sie nehmen Dofetilid

Sie haben Anamie, die durch niedrige Folsaure im Blut oder Urin Blockade verursacht

Sie sind in der Woche 38 der Schwangerschaft oder spater (full-term) oder stillen

der Patient ist ein Kind junger als 2 Monate alt

werden Sie erhalten eine Live oralen Typhus-Impfstoff.

Fragen Sie Ihren Arzt oder Ihre Arztin sofort, wenn einer dieser Punkte auf Sie zutreffen.

Einige medizinische Bedingungen konnen mit Bactrim interagieren. Informieren Sie Ihren Arzt oder Apotheker, wenn Sie irgendwelche medizinischen Bedingungen haben, vor allem, wenn einer der folgenden Punkte auf Sie zutrifft:

wenn Sie schwanger sind, planen, schwanger zu werden, oder stillen

Wenn Sie verschreibungspflichtige (insbesondere Anfall-Medikamente) oder nicht verschreibungspflichtige Arzneimittel, pflanzliche Zubereitung oder diatetische Erganzung

wenn Sie Allergien gegen Medikamente, Nahrungsmittel oder andere Substanzen,

wenn Sie eine Leber-oder Nierenerkrankungen, Blut-Probleme (zB Anamie, Porphyrie), Asthma oder HIV-Infektion

wenn Sie eine schwere Allergien, Glucose-6-Phosphat-Dehydrogenase-Mangel, oder ein Enzym-Mangel

Wenn Sie mit einem Risiko fur niedrige Folsaure im Blut sind (zB haben Sie Alkoholismus, Sie alter sind, mussen Sie nicht die Aufnahme von Nahrstoffen aus der Nahrung richtig, Sie in einem schlechten Ernahrungszustand sind, werden Sie die Einnahme von Medizin fur Anfalle).

Einige Arzneimittel konnen mit Bactrim interagieren. Informieren Sie Ihren Arzt, wenn Sie andere Arzneimittel einnehmen, vor allem einer der folgenden Eigenschaften sind:

Leucovorin weil es Bactrim die Effektivitat verringern kann

Angiotensin-Converting-Enzym (ACE)-Inhibitoren (zB Enalapril) oder Diuretika (beispielsweise Hydrochlorothiazid), weil sie das Risiko von Nebenwirkungen ist Bactrim kann

Antikoagulantien (zB Warfarin), weil das Risiko von Blutungen erhoht werden kann

Dofetilid weil das Risiko von schweren Herzproblemen kann erhoht werden

Digoxin, Methotrexat, Phenytoin, Sulfone (zB Dapson) oder Sulfonylharnstoffen (zB, Glipizid), weil das Risiko der Nebenwirkungen konnen durch Bactrim erhoht werden

BCG Impfstoff oder oralen Typhus-Impfstoff, weil ihre Wirksamkeit von Bactrim kann verringert werden

Cyclosporin, weil ihre Wirksamkeit verringert werden kann und das Risiko von Nebenwirkungen Leber gesteigert werden kann.

Dies kann nicht eine vollstandige Liste aller Interaktionen, die auftreten konnen. Fragen Sie Ihren Arzt, wenn Bactrim mit anderen Medikamenten, die Sie einnehmen. Prufen Sie mit Ihrem Arzt, bevor Sie starten, stoppen, oder andern Sie die Dosis einer Medizin.

Wichtige Sicherheitshinweise:

Bactrim kann Sie mehr leicht zu Sonnenbrand. Meiden Sie die Sonne, Hohensonne oder Solarien, bis Sie wissen, wie Sie Bactrim reagieren. Verwenden Sie einen Sonnenschutz-und Schutzkleidung tragen mussen, wenn Sie fur mehr als eine kurze Zeit au?erhalb.

Mild Durchfall ist mit einer Antibiotika-Einsatz ublich. Allerdings kann eine schwere Form von Durchfall (pseudomembranose Kolitis) selten auftreten. Dies kann zu entwickeln, wahrend Sie das Antibiotikum oder innerhalb von mehreren Monaten, nachdem Sie mit ihn zu stoppen verwenden. Fragen Sie Ihren Arzt sofort, wenn Bauchschmerzen oder Krampfe, schwerer Durchfall oder Blut im Stuhl auftreten. Behandeln Sie Durchfall nicht, ohne vorher Rucksprache mit Ihrem Arzt.

Fragen Sie Ihren Arzt sofort, wenn Bauchschmerzen oder Krampfe, schwerer Durchfall oder Blut im Stuhl wahrend der Behandlung oder innerhalb von mehreren Monaten auftreten, nachdem die Behandlung mit Bactrim. Behandeln Sie Durchfall nicht, ohne vorher Rucksprache mit Ihrem Arzt.

Achten Sie darauf, Bactrim fur das gesamte Verlauf der Behandlung zu verwenden. Wenn Sie das nicht tun, kann die Medizin nicht klar, bis Ihre Infektion vollstandig. Die Bakterien konnten auch weniger anfallig fur diese oder andere Arzneimittel. Dies konnte die Infektion schwerer zu behandeln in der Zukunft.

Bactrim funktioniert nur gegen Bakterien, es nicht zu behandeln virale Infektionen (zB eine Erkaltung).

Langfristige oder wiederholte Verwendung von Bactrim kann eine zweite Infektion. Informieren Sie Ihren Arzt, wenn Sie Anzeichen einer zweiten Infektion auftreten. Ihr Arzneimittel mussen geandert werden, um diese zu behandeln.

Diabetes-Patienten - Bactrim beeintrachtigen konnen Sie Ihren Blutzucker. Check Blutzucker eng. Fragen Sie Ihren Arzt, bevor Sie die Dosis Ihres Diabetes Medizin zu andern.

Bactrim kann mit bestimmten Labortests. Achten Sie darauf, Ihren Arzt und Labor-Mitarbeiter wissen, dass Sie nehmen Bactrim.

Labortests, einschlie?lich Blutbild und Nierenfunktion, kann durchgefuhrt werden, wahrend Sie Bactrim verwenden. Diese Tests konnen verwendet werden, um Ihren Zustand zu uberprufen oder auf Nebenwirkungen zu uberwachen. Achten Sie darauf, alle Arzt-und Labor-Terminen.

Verwenden Sie Bactrim mit Vorsicht bei alteren Menschen, sie kann mehr empfindlich auf die Auswirkungen, vor allem schwere Hautreaktionen, Knochenmarksuppression oder hohe Kaliumspiegel im Blut.

Bactrim sollte nicht bei Kindern junger 2 Monate verwendet werden, Sicherheit und Wirksamkeit bei diesen Kindern haben sich nicht bestatigt.

Schwangerschaft und Stillzeit: Wenn Sie schwanger werden, wenden Sie sich an Ihren Arzt. Sie mussen die Vorteile und Risiken der Verwendung von Bactrim zu diskutieren, wahrend Sie schwanger sind. Verwenden Sie keine Bactrim, wenn Sie in der Woche 38 der Schwangerschaft oder spater (full-term) sind. Bactrim ist in der Muttermilch gefunden. Nicht stillen wahrend der Einnahme von Bactrim.



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Buy Woman S Health - Alflam (Brand Name Diclofenac) Online - Order Diclofenac - Purchase Woman S Hea

Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis. Diclofenac may also be used for purposes other than those listed in this medication guide.

Use Diclofenac as directed by your doctor.

Take Diclofenac by mouth with or without food. Ask your health care provider any questions you may have about how to use Diclofenac.

Drug Class and Mechanism

Diclofenac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

If you miss a dose of Diclofenac, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Store Diclofenac at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do not use Diclofenac if:

you are allergic to any ingredient in Diclofenac; you have had a severe allergic reaction (e. g. severe rash, hives, breathing difficulties, dizziness) to another NSAID (e. g. ibuprofen, naproxen, celecoxib) or aspirin. Contact your doctor or health care provider right away if any of these apply to you.

Important : Diclofenac may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Before you start any new medicine, check the label to see if it has Alflam or another nonsteroidal anti-inflammatory drug (NSAID) medicine in it too. If it does or if you are not sure, check with your doctor or pharmacist. Diclofenac should not be used in children; safety and effectiveness in children have not been confirmed. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breast-feed while using Diclofenac.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

burning or stinging; discharge; eye redness, irritation, or itching. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred or distorted vision; eye infection; eyelid swelling or redness; sensitivity to glare or light.

Diclofenac is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.



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Voredanin, Voredanin

Voredanin

1. MILYEN TIPUSU GYOGYSZER A VOREDANIN ES MILYEN BETEGSEGEK ESETEN ALKALMAZHATO? A Voredanin a "sztatinok" csoportjaba tartozik, amelyek a lipid (verzsir) szintet szabalyozo gyogyszerek. A Voredanin az etrendi valtoztatasok kiegeszitesere hasznalhato a verzsirok, mint a koleszterin es trigliceridek szintjenek csokkentesere, ha az alacsony zsirtartalmu etrend es az eletmodvaltas onmagukban nem elegsegesek. Amennyiben Onnel emelkedett a szivbetegseg kialakulasanak kockazata, a Voredanin alkalmazhato a kockazat csokkentesere abban az esetben is, ha az On koleszterinszintje megfelelo. A kezeles alatt folytassa a standard alacsony koleszterintartalmu etrendet. 2. TUDNIVALOK A VOREDANIN SZEDESE ELOTT Ne szedje a Voredanint - ha allergias (tulerzekeny) az atorvasztatinra vagy barmely hasonlo, a verzsirszint csokkentesere alkalmazott gyogyszerre, vagy a Voredanin egyeb osszetevojere - reszletesebben lasd a 6. pontban, - ha majbetegsege van vagy volt korabban, - ha Onnel vervizsgalat soran a maj mukodeset jellemzo, tisztazatlan eredetu, koros eredmenyt talaltak, - ha fogamzokepes no, es nem alkalmaz megbizhato fogamzasgatlo modszert, - ha terhes vagy teherbe kivan esni, - ha szoptat. A Voredanin fokozott elovigyazatossaggal alkalmazhato A kovetkezokben felsorolt okok miatt a Voredanin lehet, hogy nem megfelelo az On szamara: - ha korabban agyverzessel jaro szelutese (sztrok) volt, vagy az agyaban korabbi sztrokbol visszamarado kicsi, folyadekkal telt uregek vannak, - ha veseproblemai vannak, - ha Onnel pajzsmirigy-alulmukodes (hipotireozis) all fenn, - ha ismetelt vagy tisztazatlan eredetu izomfajdalma volt, valamint ha Onnel vagy csaladjaban izombetegseg fordult elo, - ha egyeb lipidcsokkento gyogyszerekkel (pl. "sztatinok" vagy "fibratok" neven ismert gyogyszerek) torteno kezeles soran korabban izomproblemai voltak, - ha rendszeresen nagy mennyisegu alkoholt fogyaszt, - ha korelozmenyeben majbetegseg szerepel, - ha 70 evesnel idosebb. Szamoljon be kezeloorvosanak es gyogyszereszenek a Voredanin filmtablettaval tortent kezeles elott - ha Onnek sulyos legzesi elegtelensege van. Ha a fentiek barmelyike igaz Onre, kezeloorvosa a Voredanin-kezeles megkezdese elott es valoszinuleg a kezeles soran is vervizsgalatot rendelhet el az izmokat erinto mellekhatasok kockazatanak meghatarozasa celjabol. Ismert, hogy bizonyos gyogyszerek egyideju szedese soran a vazizomzattal osszefuggo mellekhatasok, mint peldaul a vazizomsejtek szetesesenek (rabdomiolizis) emelkedik a kockazata (lasd. 2. pont "A kezeles ideje alatt szedett egyeb gyogyszerek"). Amig On ezt a gyogyszert szedi, orvosa szoros megfigyeles alatt fogja tartani, amennyiben On cukorbeteg, vagy fennall a cukorbetegseg kialakulasanak kockazata. Onnel valoszinuleg fennall a cukorbetegseg kialakulasanak kockazata, ha vereben magas a cukor - es a zsirszint, ha tulsulyos es magas vernyomasa van. A kezeles ideje alatt szedett egyeb gyogyszerek Nehany gyogyszer megvaltoztathatja a Voredanin hatasat, vagy a Voredanin valtoztathatja meg ezek hatasat. Az ilyen tipusu kolcsonhatas az egyik vagy mindket gyogyszer hatasossagat csokkentheti. Ugyanakkor megnovelheti a mellekhatasok sulyossagat, koztuk a fontos, izomkarosodassal jaro allapot, a rabdomioliziskent ismert betegseget (leirasat lasd a 4. pontban): - a szervezet immunrendszerenek mukodeset befolyasolo gyogyszerek, pl. ciklosporin, - bizonyos antibiotikumok vagy gombafertozes elleni gyogyszerek, pl. eritromicin, klaritromicin, telitromicin, ketokonazol, itrakonazol, vorikonazol, flukonazol, pozakonazol, rifampicin, fuzidinsav, - a verzsirszintet szabalyozo egyeb gyogyszerek, pl. gemfibrozil, egyeb fibratok, kolesztipol, - anginara vagy magas vernyomasra hasznalt kalciumcsatorna-blokkolok, pl. amlodipin, diltiazem; szivritmust szabalyozo gyogyszerek, pl. digoxin, verapamil, amiodaron, - HIV kezelesere hasznalt gyogyszerek, pl. ritonavir, lopinavir, atazanavir, indinavir, darunavir, stb., - egyeb gyogyszerek, melyekrol ismert, hogy kolcsonhatasba lepnek a Voredaninnal: ezetimib (koleszterinszint-csokkento), warfarin (csokkenti a verrogkepzodest), szajon at szedendo fogamzasgatlok, sztiripentol (epilepszia kezelesere hasznalt gorcsgatlo), cimetidin (gyomoregesre es fekelyekre), fenazon (fajdalomcsillapito) es savmegkotok (aluminium vagy magnezium tartalmu emesztesi zavar eseten alkalmazott termekek), - veny nelkul kaphato gyogyszerek: orbancfu. Tajekoztassa kezeloorvosat, a jelenleg vagy nemregiben szedett egyeb gyogyszereirol, beleertve a veny nelkul kaphato keszitmenyeket is. A Voredanin egyideju bevetele bizonyos etelekkel vagy italokkal A Voredanin alkalmazasara vonatkozo utasitasokat lasd 3. pont. Kerjuk, vegye figyelembe a kovetkezoket: Grapefruitle Ne fogyasszon egy vagy ket kis pohar grapefruitlenel tobbet naponta, mert a nagy mennyisegu grapefruitle megvaltoztathatja a Voredanin hatasat. Alkohol A gyogyszer szedese soran kerulje a nagy mennyisegu alkohol fogyasztasat. Tovabbi informacioert lasd 2. pont: "A Voredanin fokozott elovigyazatossaggal alkalmazhato". Terhesseg es szoptatas Ne szedje a Voredanint, ha On terhes, vagy teherbe kivan esni. Fogamzokepes nok a Voredanint csak akkor szedhetik, ha biztonsagos fogamzasgatlo modszert alkalmaznak. Ne szedje a Voredanint, ha On szoptat. A Voredanin biztonsagossaga terhesseg es szoptatas ideje alatt eddig nem bizonyitott. Mielott barmilyen gyogyszert elkezdene szedni, beszelje meg kezeloorvosaval vagy gyogyszereszevel. A keszitmeny hatasai a gepjarmuvezeteshez es gepek kezelesehez szukseges kepessegekre Ez a gyogyszer altalaban nem befolyasolja a gepjarmuvezeteshez es gepek kezelesehez szukseges kepessegeket. Azonban ne vezessen, ha ez a gyogyszer befolyasolja a gepjarmuvezeteshez szukseges kepessegeit. Ne hasznaljon eszkozoket vagy gepeket, ha ez a gyogyszer befolyasolja az alkalmazashoz szukseges kepessegeit. 3. HOGYAN KELL SZEDNI A VOREDANINT? A kezeles megkezdese elott a kezeloorvos koleszterinszegeny dietat fog eloirni, amit a Voredanin-kezeles ideje alatt is be kell tartani. A Voredanin szokasos kezdo adagja felnotteknel naponta 1-szer 10 mg. Kezeloorvosa szukseg eseten emelheti az adagot az On szamara szukseges adag elereseig. Kezeloorvosa az adagot 4 hetes vagy hosszabb idokozonkent fogja modositani. A Voredanin legnagyobb napi adagja 80 mg. A Voredanin tablettat keves folyadekkal, egeszben nyelje le. A tablettat a nap folyaman barmikor, etkezes kozben vagy attol fuggetlenul is beveheti, azonban probalja meg a tablettat minden nap azonos idoben bevenni. A Voredanint mindig az orvos altal elmondottaknak megfeleloen szedje. Amennyiben nem biztos az adagolast illetoen, kerdezze meg kezeloorvosat vagy gyogyszereszet. A Voredanin-kezeles idotartamat kezeloorvosa hatarozza meg. Kerdezze meg kezeloorvosat, ha ugy gondolja, hogy a Voredanin hatasa tul eros vagy tul gyenge. Ha az eloirtnal tobb Voredanint vett be Ha veletlenul tul sok Voredanin tablettat vett be (tobbet, mint az On szokasos napi adagja), ertesitse kezeloorvosat vagy a legkozelebbi korhazat. Ha elfelejtette bevenni a Voredanint Ha elfelejtett bevenni egy adagot, csak a kovetkezo adagot vegye be a szokasos idopontban. Ne vegyen be ketszeres adagot a kihagyott adag potlasara. Ha ido elott abbahagyja a Voredanin szedeset Ha tovabbi kerdese van a keszitmeny alkalmazasaval kapcsolatban, vagy abba szeretne hagyni a kezelest, kerdezze meg kezeloorvosat vagy gyogyszereszet. 4. LEHETSEGES MELLEKHATASOK Mint minden gyogyszer, igy a Voredanin is okozhat mellekhatasokat, amelyek azonban nem mindenkinel jelentkeznek. Ha a kovetkezo sulyos mellekhatasok barmelyiket tapasztalja, hagyja abba a gyogyszer szedeset, es azonnal ertesitse kezeloorvosat vagy menjen el a legkozelebbi korhaz surgossegi osztalyara. Ritka: 10 000-bol 1-10 beteget erint: - Sulyos allergias reakcio, mely az arc, a nyelv es a torok duzzanatahoz vezet, amely sulyos legzesi nehezseget okozhat. - A bor sulyos hamlasaval es duzzanataval, a boron, szajban, a szemek es nemi szervek kornyeken felholyagosodassal es lazzal jaro sulyos betegseg. Rozsaszin-piros borkiutesek kulonosen a tenyereken es talpakon, melyek felholyagosodhatnak. - Az izomgyengeseget, erzekenyseget vagy fajdalmat koros izomlebomlas is okozhatja, kulonosen, ha egyidejuleg rossz kozerzet vagy magas laz jelentkezik, mely eletet veszelyezteto lehet, es veseproblemakhoz vezethet. Nagyon ritka: 10 000-bol kevesebb, mint 1 beteget erint. - Ha varatlan vagy szokatlan verzes, vagy veralafutas jelentkezik Onnel, ez majpanaszokra utalhat. Beszeljen orvosaval, amint lehetseges. A Voredanin egyeb, lehetseges mellekhatasai Gyakori mellekhatasok (100-bol 1-10 beteget erint) koze tartozik: - az orrjaratok gyulladasa, torokfajas, orrverzes - allergias reakciok - a vercukorszint emelkedese (ha On cukorbeteg, folytassa vercukorszintjenek gondos ellenorzeset), a ver kreatin-kinaz-szintjenek emelkedese - fejfajas - emelyges, szekrekedes, puffadas, emesztesi zavarok, hasmenes - izuleti fajdalom, izomfajdalom es hatfajas - koros majmukodesre utalo vervizsgalati eredmenyek Nem gyakori mellekhatasok (1000-bol 1-10 beteget erint) koze tartozik: - etvagycsokkenes (anorexia), testtomeg-novekedes, vercukorszint-csokkenes (ha On cukorbeteg, folytassa vercukorszintjenek gondos ellenorzeset) - remalmok, almatlansag - szedules, a kez, illetve a lab ujjainak zsibbadasa vagy erzeketlensege, a fajdalom - es tapintaserzes csokkenese, az izerzekeles megvaltozasa, emlekezetkieses - homalyos latas - zugas a fulben es/vagy a fejben - hanyas, bofoges, felso es also hasi fajdalom, hasnyalmirigy-gyulladas, mely gyomorfajast okozhat (pankreatitisz) - majgyulladas (hepatitisz) - kiutes, borkiutes, borviszketes, csalankiutes, hajhullas - nyakfajas, az izmok faradekonysaga - nagyfoku faradtsag, rossz kozerzet, gyengeseg, mellkasi fajdalom, duzzanat, kulonosen a bokak korul, emelkedett testhomerseklet - feherversejtek jelenletet kimutato vizeletvizsgalat Ritka mellekhatasok (10 000-bol 1-10 beteget erint) koze tartozik: - lataszavarok - varatlan verzes vagy veralafutas - epepangas (a bor es a szemfeherje besargulasa) - inserules Nagyon ritka mellekhatasok (10 000-bol kevesebb, mint 1 beteget erint) koze tartozik: - allergias reakcio - tunetei lehetnek a hirtelen zihalas es mellkasi fajdalom vagy szoritas, a szemhej, az arc, az ajkak, a szaj, a nyelv vagy a torok duzzanata, legzesi nehezseg, ajulas - hallascsokkenes - ferfiaknal es noknel az emlo megnagyobbodasa (ginekomasztia). A kovetkezo mellekhatasokat jelentettek nehany "sztatin" (azonos csoportba sorolhato gyogyszer) alkalmazasaval kapcsolatban: - Szexualis nehezsegek - Depresszio - Legzesi problemak, mint a tartos kohoges es/vagy legszomj, vagy laz - Cukorbetegseg. A cukorbetegsegnek nagyobb a valoszinusege, amennyiben az On vereben magas a cukor - es a zsirszint, ha tulsulyos es magas vernyomasa van. Amig On ezt a gyogyszert szedi, orvosa megfigyeles alatt fogja tartani. Ha barmely mellekhatas sulyossa valik, vagy ha a betegtajekoztatoban felsorolt mellekhatasokon kivul egyeb tunetet eszlel, kerjuk, ertesitse orvosat vagy gyogyszereszet. 5. HOGYAN KELL A VOREDANINT TAROLNI? A gyogyszer gyermekektol elzarva tartando! A csomagolason feltuntetett lejarati ido (Felh.:) utan ne szedje a Voredanint. A lejarati ido a megadott honap utolso napjara vonatkozik. Legfeljebb 25 °C-on tarolando. A gyogyszereket nem szabad a szennyvizzel vagy a haztartasi hulladekkal egyutt megsemmisiteni. Kerdezze meg gyogyszereszet, hogy szuksegtelenne valt gyogyszereit mikent semmisitse meg. Ezek az intezkedesek elosegitik a kornyezet vedelmet. 6. TOVABBI INFORMACIOK Mit tartalmaz a Voredanin - A keszitmeny hatoanyaga az atorvasztatin. 10 mg, 20 mg, illetve 40 mg atorvasztatin (atorvasztatin-kalcium formajaban) filmtablettankent. - Egyeb osszetevok: tabletta mag . mannit (E421), mikrokristalyos celluloz, kalcium-karbonat (E170), povidon (K30), kroszkarmelloz-natrium, natrium-lauril-szulfat, vizmentes kolloid szilicium-dioxid, magnezium-sztearat; tabletta bevonat . hipromelloz 6 cP (E464), titan-dioxid (E171), makrogol (6000). Milyen a Voredan in kulleme es mit tartalmaz a csomagolas 10 mg: feher, kerek, mindket oldalan domboru feluletu, 7 mm atmeroju filmtabletta. 20 mg: feher, kerek, mindket oldalan domboru feluletu, 9 mm atmeroju filmtabletta. 40 mg: feher, ovalis, mindket oldalan domboru feluletu, 8,2 x 17 mm atmeroju filmtabletta. Filmtabletta (OPA/Al//PVC/Al) buborekcsomagolasban es dobozban: 4, 7, 10, 14, 20, 28, 30, 50, 56, 84, 98, 100, 200 (10 x 20), 500 minden hataserossegben. Nem feltetlenul mindegyik kiszereles kerul kereskedelmi forgalomba.

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Omez - 10 (Capsule); Omez - 20 (Capsule); Omez - 40 (Capsule), Omezyn

PROPRIETARY NAME (and dosage form):

OMEZ 10 (capsule) OMEZ 20 (capsule) OMEZ 40 (capsule)

COMPOSITION: OMEZ 10: Each capsule contains omeprazole 10 mg OMEZ 20: Each capsule contains omeprazole 20 mg OMEZ 40: Each capsule contains omeprazole 40 mg

PHARMACOLOGICAL CLASSIFICATION A 11.4.3 Medicines acting on the gastrointestinal tract –Other

PHARMACOLOGICAL ACTION Omeprazole is an inhibitor of the gastric proton pump (H+, K+-ATPase). It inhibits both basal and stimulated gastric acid secretion by parietal cells, whether induced by acetylcholine, gastrin or histamine. Omeprazole has no effect on acetylcholine, histamine or gastric receptors. Pharmacokinetics Orally administered omeprazole is well absorbed but to a variable extent. Absorption of omeprazole takes place in the small intestine and is usually completed within three to six hours. Bioavailability depends on dose and gastric pH and may reach 70% with repeated administration. Food has no influence on the bioavailability of omeprazole. Omeprazole is more than 95% bound to plasma proteins. Clearance from the circulation is by hepatic metabolism with a plasma half-life of 30 to 90 minutes. Hepatic metabolism occurs primarily via the cytochrome P450 (CYP) isoform (CYP2C19). The inactive metabolites are excreted mainly in the urine (80%) whilst the remaining 20% are excreted via the faeces. The average half-life of the terminal phase of the plasma concentration-time curve is approximately 40 minutes. There is no change in plasma half - life during treatment. The inhibition of acid secretion is related to the area under the plasma concentration - time curve (AUC) and not to the actual plasma concentration at a given time.

Treatment of duodenal ulcer, including prevention of relapse gastric ulcer and reflux oesophagitis.

Long-term management of reflux oesophagitis and Zollinger-Ellison Syndrome.

Symptomatic relief of heartburn in patients with gastro-oesophageal reflux disease (GORD) and the short-term relief of functional dyspepsia.

Helicobacter pylori-positive duodenal ulcers as part of an eradication programme with appropriate antibiotics.

Treatment of non-steroidal anti-inflammatory drugs (NSAID)-associated gastric and/or duodenal ulcer/erosions.

Reduction of the risk to develop gastric and/or duodenal ulcer/erosions and reduction of the risk of relapse for previously healed gastric and/or duodenal ulcer/erosions in patients on NSAID treatment.

Short-term (up to 3 months) treatment of severe ulcerative reflux oesophagitis resistant to previous medical treatment.

CONTRA-INDICATIONS Hypersensitivity to any of the ingredients Safety in pregnancy and lactation has not been established

WARNINGS Symptomatic response to OMEZ therapy does not preclude the presence of gastric ulcer or malignancy or a malignant disease of the oesophagus. The administration of OMEZ in this situation may delay diagnosis (see Special Precautions). Hepatic impairment may require a reduction in dose (see DOSAGE AND DIRECTIONS FOR USE). THERE IS VERY LIMITED EXPERIENCE WITH THE USE OF OMEZ IN CHILDREN. THE LONG-TERM SAFETY OF OMEZ IN PATIENTS WITH RENAL AND/OR HEPATIC IMPAIRMENT HAS NOT BEEN ESTABLISHED. THIS MEDICINE MAY LEAD TO DROWSINESS AND IMPAIRED CONCENTRATION THAT MAY BE AGGRAVATED BY THE SIMULTANEOUS INTAKE OF ALCOHOL OR OTHER CENTRAL NERVOUS SYSTEM DEPRESSANTS. PATIENTS SHOULD BE ADVISED, PARTICULARLY AT THE INITIATION OF THERAPY, AGAINST TAKING CHARGE OF VEHICLES OR MACHINERY OR PERFORMING POTENTIALLY HAZARDOUS TASKS WHERE LOSS OF CONCENTRATION COULD LEAD TO ACCIDENTS.

INTERACTIONS OMEZ is metabolised via the hepatic P450 cytochrome enzyme system, which may affect the metabolism of other medications metabolised by these enzymes, when given concomitantly. The elimination of diazepam, warfarin and phenytoin may be prolonged when OMEZ is given concomitantly. Monitoring of INR and phenytoin serum levels is recommended and dosage reductions may be necessary when OMEZ is given concomitantly. There is a possible interaction of OMEZ with digoxin and a 10% increase in digoxin bioavailability may be expected. There may be interactions with other medicines, which are also metabolised via the cytochrome P450 enzyme system.

PREGNANCY AND LACTATION Safety in pregnancy and lactation has not been established (see CONTRAINDICATIONS).

DOSAGE AND DIRECTIONS FOR USE OMEZ is recommended to be given in the morning and swallowed whole with a half glass of liquid. The capsules should not be chewed or crushed. RECOMMENDED DOSAGES FOR ADULTS Duodenal ulcer 20 mg once daily for two to four weeks. In some duodenal ulcer patients refractory to other treatment regimens, 40 mg once daily may be effective. Prevention of relapse in patients with duodenal ulcer 10 mg once daily. If necessary the dose can be increased to 20 –40 mg once daily. The above recommended dosage regimens are inclusive of Helicobacter pylori-positive duodenal ulcers as part of the eradication programme with appropriate antibiotics. Gastric ulcer and reflux oesophagitis 20 mg once daily for four to eight weeks. In some gastric ulcer and reflux oesophagitis patients refractory to other treatment regimens, 40 mg once daily may be effective. For the long-term management of patients with reflux oesophagitis the recommended dose is 20 mg once daily. If necessary the dose can be increased to 20 –40 mg once daily. In patients with severe or symptomatic recurrent reflux oesophagitis treatment can be continued with OMEZ at a dosage of 20 mg once daily. NSAID-associated gastro-duodenal lesions with or without continued NSAID treatment 20 mg once daily. In most patients healing occurs within 4 weeks. For patients who may not be fully healed after the initial course healing usually occurs during a further 4 weeks of treatment. Prevention of NSAID-associated gastro-duodenal lesions and dyspeptic symptoms 20 mg once daily. Symptomatic gastro-oesophageal reflux disease 20 mg daily. Patients may respond adequately to 10 mg daily, therefore individual dose adjustments should be considered. If symptom control has not been achieved after 2 weeks of treatment with 20 mg daily further investigation is recommended. Zollinger-Ellison Syndrome 60 mg once daily. The dosage should be adjusted individually and treatment continued as long as it is clinically indicated. With doses above 80 mg daily the dose should be divided and given twice daily. There is very limited experience with the use of OMEZ in children (see WARNINGS). Severe ulcerative reflux oesophagitis in children from one year and older Recommended dosages:

10 mg once daily.

If needed increase to 20 mg once daily

20 mg once daily.

If needed increase to 40 mg once daily

Elderly Dose reductions are not necessary in elderly patients. The long-term safety of OMEZ in patients with renal and hepatic impairment has not been established (see WARNINGS). Impaired renal function Dose reductions are not necessary in renal impairment. Impaired hepatic function Bioavailability and plasma half-life of OMEZ are increased in patients with impaired hepatic function, therefore a daily dose of 10 –20 mg is generally sufficient.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS Side-effects Blood and lymphatic system disorders Rare . Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia Endocrine disorders Rare . Gynaecomastia Metabolic and nutritional disorders Rare . Hyponatraemia Psychiatric disorders Rare . Reversible mental confusion, agitation, aggression, depression and hallucinations (predominantly in severely ill patients) Nervous system disorders Common . Headache (severe enough to cause discontinuation in some patients) Uncommon . Dizziness, somnolence, insomnia, parasthaesias Eye disorders Rare . Blurred vision Vascular disorders Rare . Peripheral oedema Respiratory, thoracic and mediastinal disorders Rare . Bronchospasm Gastrointestinal disorders Common . Diarrhoea (severe enough to require discontinuation of therapy in some patients), constipation, abdominal pain or colic, nausea, vomiting, flatulence Rare . Dry mouth, stomatitis, oesophageal candidiasis, taste disturbances Hepato-biliary disorders Uncommon . Raised liver enzymes Rare . Hepatitis with or without jaundice, hepatic encephalopathy Skin and subcutaneous tissue disorders Uncommon . Skin rash, urticaria, pruritus Rare . Photosensitivity, bullous eruption, toxic epidermal necrolysis, Stevens-Johnson syndrome, alopecia, erythema multiforme Musculoskeletal, connective tissue and bone disorders Rare . Asthenia, arthralgia, myalgia Renal and urinary disorders Rare . Interstitial nephritis Other Uncommon . Malaise Rare . Hypersensitivity reactions (e. g. fever, angioedema, bronchospasm, interstitial nephritis) and anaphylactic shock

Special precautions Effects related to acid inhibition: During long-term treatment gastric glandular cysts have been reported in increased frequency. These physiological changes result from pronounced inhibition of gastric acid secretion. Decreased gastric acidity increases gastric counts of bacteria normally present in the gastro-intestinal tract. Treatment with OMEZ may lead to an increased risk of gastro-intestinal infections such as Salmonella and Campylobacter. In the presence of symptoms such as significant unintentional weight loss, recurrent vomiting, dysphagia, haematemesis, or melaena, and when gastric ulcer is suspected or present, malignancy should be excluded, as treatment with OMEZ may alleviate symptoms and delay diagnosis.

KNOWN SYMPTOMS OF OVER-DOSAGE AND PARTICULARS OF ITS TREATMENT Blurred vision, confusion, diaphoresis, flushing, headache, malaise, nausea and tachycardia have been reported from over-dosage with omeprazole. There is no specific antidote for overdose with omeprazole. TREATMENT IS SYMPTOMATIC AND SUPPORTIVE. Due to extensive protein binding omeprazole is not readily dialysable. Patients in whom overdose is confirmed or suspected should be referred for medical practitioner/ doctor consultation.

IDENTIFICATION OMEZ 10 . Off-white to pale yellow elliptical to spherical enteric-coated pellets, filled in a hard gelatin capsule with opaque lavender coloured cap and opaque yellow coloured body. “Omeprazole 10 mg”imprinted with black ink on cap and “R157”imprinted with black ink on body. OMEZ 20 . Off-white to pale yellow elliptical to spherical enteric-coated pellets, filled in a hard gelatin capsule with opaque lavender coloured cap and opaque iron grey coloured body. “Omeprazole 20 mg” imprinted with black ink on cap and “R158”imprinted with black ink on body. OMEZ 40 . Off-white to pale yellow elliptical to spherical enteric-coated pellets, filled in a hard gelatin capsule with opaque yellow coloured cap and opaque lavender coloured body. “Omeprazole 40 mg”imprinted with black ink on cap and “R159”imprinted with black ink on body.

Blister packaging containing 30 capsules

Blister packaging containing 30 capsules

White plastic bottles containing 30 capsules

Blister packaging containing 14 capsules

STORAGE INSTRUCTIONS Store below 25°C. Protect from light and moisture. Store the blisters in the outer carton until required for use. Store the container well closed. KEEP OUT OF REACH OF CHILDREN.

REGISTRATION NUMBER OMEZ 10 . 34/11.4.3/0299 OMEZ 20 . 34/11.4.3/0300 OMEZ 40 . 34/11.4.3/0301

NAME AND BUSINESS ADDRESS OF THE HOLDER OF THE CERTIFICATE OF REGISTRATION Dr. Reddy’s Laboratories (Pty) Ltd 3rd Floor, TA Bank Building 160 Jan Smuts Avenue Rosebank 2196 Johannesburg

DATE OF PUBLICATION OF THE PACKAGE INSERT April 2007

New addition to this site: January 2008 Source: Pharmaceutical Industry SAEPI HOME PAGE TRADE NAME INDEX GENERIC NAME INDEX FEEDBACK Information presented by Malahyde Information Systems © Copyright 1996-2008



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