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Losartan

What is losartan?

Losartan (Cozaar) belongs to a group of drugs called angiotensin II receptor antagonists. It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Losartan is used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease.

Losartan is used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.

Losartan may also be used for purposes not listed in this medication guide.

Important information

Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control.

You should not use this medication if you are allergic to losartan.

If you have diabetes, do not use losartan together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

In rare cases, losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Before taking this medicine

You should not use losartan if you are allergic to it.

If you have diabetes, do not use losartan together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna). You may also need to avoid taking this medicine with aliskiren if you have kidney disease.

To make sure losartan is safe for you, tell your doctor if you have:

congestive heart failure;

an electrolyte imbalance (such as low levels of potassium in your blood); or

if you are dehydrated.

FDA pregnancy category D. Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control.

It is not known whether losartan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take losartan?

Take losartan exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take losartan with or without food.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.

Your blood pressure will need to be checked often. Visit your doctor regularly.

It may take 3 to 6 weeks of using losartan before your blood pressure is under control. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 3 weeks of treatment.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Drinking alcohol can further lower your blood pressure and may increase certain side effects of losartan.

Do not use potassium supplements or salt substitutes while you are taking this medicine, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Losartan side effects

Get emergency medical help if you have any of these signs of an allergic reaction to losartan: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Call your doctor at once if you have:

a feeling that you might pass out;

pain or burning when you urinate;

pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;

wheezing, chest pain;

drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting;

swelling, weight gain, feeling short of breath, urinating less than usual or not at all; or

high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling).

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Alesse, Altavera, Amethyst, Aviane, Enpresse, Lessina, Levlen, Levora, Lutera, Lybrel, Nordette, Ors

Brand Names: Alesse, Altavera, Amethyst, Aviane, Enpresse, Lessina, Levlen, Levora, Lutera, Lybrel, Nordette, Orsythia, Portia, Sronyx, Tri-Levlen, Triphasil-21, Triphasil-28, Trivora-28

Generic Name: ethinyl estradiol and levonorgestrel (Pronunciation: ETH in ill ess tra DYE ol and LEE vo nor JESS trel)

What is ethinyl estradiol and levonorgestrel (Alesse, Altavera, Amethyst, Aviane, Enpresse, Lessina, Levlen, Levora, Lutera, Lybrel, Nordette, Orsythia, Portia, Sronyx, Tri-Levlen, Triphasil-21, Triphasil-28, Trivora-28)?

Ethinyl estradiol and levonorgestrel is a combination drug that contains female hormones that prevent ovulation (the release of an egg from an ovary). This medication also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

Ethinyl estradiol and levonorgestrel may also be used for purposes not listed in this medication guide.

Levora

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Trivora

What are the possible side effects of ethinyl estradiol and levonorgestrel?

Get emergency medical help if you have any of these signs of an allergic reaction . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using birth control pills and call your doctor at once if you have a serious side effect such as:

sudden numbness or weakness, especially on one side of the body;

sudden and severe headache. confusion, problems with vision, speech, or balance;

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

sudden cough. wheezing, rapid breathing, coughing up blood;

pain, swelling, warmth, or redness in one or both legs;

a change in the pattern or severity of migraine headaches;

nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

swelling in your hands, ankles, or feet;

a breast lump; or

symptoms of depression (sleep problems, weakness, tired feeling, mood changes).

Less serious side effects may include:

mild nausea (especially when you first start taking this medicine), vomiting, bloating, stomach cramps;

breast tenderness or swelling, nipple discharge;

freckles or darkening of facial skin, increased hair growth, loss of scalp hair;

changes in weight or appetite;

problems with contact lenses ;

vaginal itching or discharge; or

changes in your menstrual periods, decreased sex drive.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ethinyl estradiol and levonorgestrel?

Do not use birth control pills if you are pregnant or if you have recently had a baby.

You should not take birth control pills if you have any of the following conditions: uncontrolled high blood pressure. heart disease. a blood-clotting disorder, circulation problems, diabetic problems with your eyes or kidneys, unusual vaginal bleeding. liver disease or liver cancer. severe migraine headaches, if you smoke and are over 35, or if you have ever had breast or uterine cancer, jaundice caused by birth control pills, a heart attack. a stroke. or a blood clot.

You may need to use back up birth control, such as condoms or a spermicide, when you first start using this medication or if you miss a dose. Follow your doctor's instructions.

Missing a pill increases your risk of becoming pregnant. Carefully follow the "missed dose" instructions if you forget to take your birth control pills.

Some drugs can make birth control pills less effective in preventing pregnancy, including antibiotics. hepatitis C medications. HIV/AIDS medications, seizure medications, or barbiturate sedatives. Tell your doctor about all other medications you use.

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Metoclopramide Medlineplus Drug Information, Maxeran

Metoclopramide

IMPORTANT WARNING:

Taking metoclopramide may cause you to develop a muscle problem called tardive dyskinesia. If you develop tardive dyskinesia, you will move your muscles, especially the muscles in your face in unusual ways. You will not be able to control or stop these movements. Tardive dyskinesia may not go away even after you stop taking metoclopramide. The longer you take metoclopramide, the greater the risk that you will develop tardive dyskinesia. Therefore, your doctor will probably tell you not to take metoclopramide for longer than 12 weeks. The risk that you will develop tardive dyskinesia is also greater if you are taking medications for mental illness, if you have diabetes, or if you are elderly, especially if you are a woman. Call your doctor immediately if you develop any uncontrollable body movements, especially lip smacking, mouth puckering, chewing, frowning, scowling, sticking out your tongue, blinking, eye movements, or shaking arms or legs.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with metoclopramide and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www. fda. gov/Drugs/DrugSafety/ucm085729.htm ) or the manufacturer's website to obtain the Medication Guide.

Talk to your doctor about the risks of taking metoclopramide.

Why is this medication prescribed?

Metoclopramide is used to relieve heartburn and speed the healing of ulcers and sores in the esophagus (tube that connects the mouth to the stomach) in people who have gastroesophageal reflux disease (GERD; condition in which backward flow of acid from the stomach causes heartburn and injury of the esophagus) that did not get better with other treatments. Metoclopramide is also used to relieve symptoms caused by slow stomach emptying in people who have diabetes. These symptoms include nausea, vomiting, heartburn, loss of appetite, and feeling of fullness that lasts long after meals. Metoclopramide is in a class of medications called prokinetic agents. It works by speeding the movement of food through the stomach and intestines.

How should this medicine be used?

Metoclopramide comes as a tablet, an orally disintegrating (dissolving) tablet, and a solution (liquid) to take by mouth. It is usually taken 4 times a day on an empty stomach, 30 minutes before each meal and at bedtime. When metoclopramide is used to treat symptoms of GERD, it may be taken less frequently, especially if symptoms only occur at certain times of day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metoclopramide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are taking the orally disintegrating tablet, use dry hands to remove the tablet from the package just before you take your dose. If the tablet breaks or crumbles, throw it away and remove a new tablet from the package. Gently remove the tablet and immediately place it on the top of your tongue. The tablet will usually dissolve in about one minute and can be swallowed with saliva.

If you are taking metoclopramide to treat the symptoms of slow stomach emptying caused by diabetes, you should know that your symptoms will not improve all at once. You may notice that your nausea improves early in your treatment and continues to improve over the next 3 weeks. Your vomiting and loss of appetite may also improve early in your treatment, but it may take longer for your feeling of fullness to go away.

Continue to take metoclopramide even if you feel well. Do not stop taking metoclopramide without talking to your doctor. You may experience withdrawal symptoms such as dizziness, nervousness, and headaches when you stop taking metoclopramide.

Other uses for this medicine

Metoclopramide is also sometimes used to treat the symptoms of slowed stomach emptying in people who are recovering from certain types of surgery, and to prevent nausea and vomiting in people who are being treated with chemotherapy for cancer. Ask your doctor about the risks of using this medication to treat your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Metoclopramide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

drowsiness

excessive tiredness

weakness

headache

dizziness

diarrhea

nausea

vomiting

breast enlargement or discharge

missed menstrual period

decreased sexual ability

frequent urination

inability to control urination

Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately:

tightening of the muscles, especially in the jaw or neck

speech problems

depression

thinking about harming or killing yourself

fever

muscle stiffness

confusion

fast, slow, or irregular heartbeat

sweating

restlessness

nervousness or jitteriness

agitation

difficulty falling asleep or staying asleep

pacing

foot tapping

slow or stiff movements

blank facial expression

uncontrollable shaking of a part of the body

difficulty keeping your balance

rash

hives

swelling of the eyes, face, lips, tongue, mouth, throat, arms, hands, feet, ankles, or lower legs

sudden weight gain

difficulty breathing or swallowing

high-pitched sounds while breathing

vision problems

Metoclopramide may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include

drowsiness

confusion

seizures

unusual, uncontrollable movements

lack of energy

bluish coloring of the skin

headache

shortness of breath

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

¶ This branded product is no longer on the market. Generic alternatives may be available.

Last Reviewed - 09/01/2010

American Society of Health-System Pharmacists, Inc. Disclaimer

AHFS ® Patient Medication Information. © Copyright, 2016. The American Society of Health-System Pharmacists, Inc. 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.



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Generic Name: Amoxicillin

What is Generic for Alphamox* used for?

Generic for Alphamox* (Amoxicillin) is used to treat bacterial infections such as E. coli infection, pneumonia, gonorrhea, bladder infection, and ear infection. It belongs to a class of antibiotics called penicillins, which work by stopping the multiplication of bacteria. This medicine may also be used to treat other conditions as determined by your doctor.

What is the recommended dosage of Generic for Alphamox*?

The dosage of Generic for Alphamox* prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.

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What if you miss a dose of Generic for Alphamox*?

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alexia

alexia

a form of receptive aphasia in which there is inability to understand written language. adj. alex´ic.

a·lex·i·a

optic alexiasensory alexiavisual alexiamotor alexia ( ă-lek'sē-ă ),

An inability to comprehend the meaning of written or printed words and sentences, caused by a cerebral lesion. Also called optic alexia, sensory alexia, visual alexia, to differentiate from motor alexia (anarthria), in which there is loss of the power to read aloud even though the significance of what is written or printed is understood.

[G. a - priv. + lexis, a word or phrase]

alexia

/alex·ia/ ( ah-lek?se-ah ) a form of receptive aphasia in which ability to understand written language is lost as a result of a cerebral lesion. alex?ic

cortical alexia a form of sensory aphasia due to lesions of the left gyrus angularis.

motor alexia alexia in which the patient understands what he sees written or printed, but cannot read it aloud.

musical alexia loss of the ability to read music.

subcortical alexia a form due to interruption of the connection between the optic center and the parietal lobe, including the gyrus angularis of the dominant hemisphere.

alexia

Loss of the ability to read, usually caused by brain lesions. Also called word blindness .

alexia

alexia

1. Inability to understand printed words or sentences.

2. Loss of a previously possessed reading facility that is unexplained by defective visual acuity Psychiatry Loss of the ability to grasp the meaning of written or printed words and sentences. See Dyslexia .

a·lex·i·a

An inability to comprehend the meaning of written or printed words and sentences, caused by a cerebral lesion. Also called optic alexia, sensory alexia, or visual alexia, in distinction to motor alexia (anarthria), in which there is loss of the power to read aloud although the significance of what is written or printed is understood. Synonym(s): text blindness. word blindness. visual aphasia (1).

[G. a - priv. + lexis, a word or phrase]

alexia

Word blindness. The inability to read, occurring as a result of brain damage, usually from arterial disease. Alexia is common after stroke affecting the left side of the brain with damage to the fibres connecting the visual part of the brain and the part concerned with the function of reading in the left angular gyrus. The word is derived from the Greek a . not and legein . to speak.

alexia

Inability to recognize written or printed words due to a lesion in the brain. This is a form of visual agnosia. Syn. word blindness. See agnosia ; dyslexia .

a·lex·i·a

Inability to comprehend the meaning of written or printed words and sentences, caused by a cerebral lesion.

[G. a - priv. + lexis, a word or phrase]



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Request for refund must be postmarked by 7/31/2016 and received at fulfillment center no later than 8/31/2016 . Allow 4-6 weeks for processing. Void where prohibited, taxed or otherwise restricted. Not responsible for late, lost, postage due or undelivered mail. No request from groups, clubs or organizations will be honored. Fraudulent submission could result in Federal prosecution under mail fraud statutes.

Unless expressly prohibited by law, payee authorizes reasonable dormancy fees deducted if refund check is not cashed within 180 days.

Valid original sales receipt and original UPC code from both actual cartons purchased must be submitted with request. Duplicated or altered documents will not be accepted. Keep a copy of the materials that you submit for your records. Absence of these documents will void any refund request.

TO REQUEST A REFUND -

STEP 1: Print and fill out the Official Request Form or include all of the information requested on the Official Request Form on a 3” X 5” card.

STEP 2: Enclose the following items with the filled out Official Request Form or 3” X 5” card.

Your original store-identified register receipt. You must circle the purchase price of the participating Children's Claritin ® products.

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Cystrin 5mg Tablets, Cystrin

CYSTRIN 5MG TABLETS

Transcript

1. What Cystrin Tablets are and what they are used for

Cystrin 5mg Tablets

What Cystrin Tablets are Cystrin Tablets contain a medicine called oxybutynin hydrochloride. This belongs to two groups of medicines called ‘anticholinergics’ and ‘antispasmodics’.

Oxybutynin hydrochloride Read all of this leaflet carefully before you start taking this medicine • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor or pharmacist • This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours. • If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. In this leaflet: 1. What Cystrin Tablets are and what they are used for. 2. Before you take Cystrin Tablets. 3. How to take Cystrin Tablets. 4. Possible side effects. 5. How to store Cystrin Tablets. 6. Further information.

How Cystrin Tablets work It works by relaxing the muscles of the bladder and stops sudden muscle contractions (spasms). This helps control the release of water (urine) What Cystrin Tablets are used for Cystrin Tablets can be used in adults and children 5 years or older to treat: • Loss of control in passing water (urinary incontinence) • Increased need or urgency to pass water (urine) • Night time bedwetting, when other treatments have not worked 2. Before you take Cystrin Tablets Do not take this medicine and tell your doctor if: ? You are allergic (hypersensitive) to oxybutynin hydrochloride or any of the other ingredients of Cystrin Tablets (listed in Section 6 Further Information) Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue 1

? You have a rare muscle illness called ‘Myasthenia gravis’ ? You have glaucoma (increased pressure in the eye, sometimes sudden and painful with blurred vision or loss of vision) ? Your gut (stomach or intestine) is blocked, perforated or not working properly ? You have a severe form of a condition known as ‘ulcerative colitis’ ? You have a blockage that makes it difficult for you to pass water (urine) Do not take this medicine if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking Cystrin Tablets. Take special care with Cystrin Tablets. Check with your doctor or pharmacist before taking your medicine if: ^ You have kidney or liver problems ^ You are 65 years of age or older ^ The person taking the medicine is a child (use is not recommended under 5 years of age) ^ You have an illness affecting the nerves called ‘autonomic neuropathy’ ^ You have an overactive thyroid gland (‘Hyperthyroidism’) ^ You have heart disease or high blood pressure ^ You have an irregular heart beat (palpitations) and/or increased or rapid heart beat

632307_NT. CYSTRIN ZTV 5 MG RL S1 GB. qxp_FORMAT 210x170mm-RL-DBL. qxd 08/04/16 16:39 Page1

PACKAGE LEAFLET: INFORMATION FOR THE USER

Taking other medicines Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you buy without a prescription, including herbal medicines. This is because Cystrin Tablets can affect the way some other medicines work. Also, some other medicines can affect the way Cystrin Tablets work. In particular, tell your doctor if you are taking any of the following: • Other anticholinergic or antimuscarinic medicines – such as some medicines

for irritable bowel syndrome, asthma or incontinence, motion sickness or movement disorders associated with Parkinson’s disease • Medicines used to make you feel sleepy (sedatives) or if you are feeling sick (nausea) or have vertigo – such as prochlorperazine or chlorpromazine • Medicines used to treat certain mental illnesses such a clozapine, phenothiazines haloperidol or benperidol (butyrophenones) • Medicines for depression – such as amitryptyline, imipramine or dosulepin (“tricyclic antidepressants”) • Amantadine – used in Parkinson’s disease or to treat and prevent some virus infections • L-dopa – used to treat Parkinson’s disease • Digoxin – used to treat heart problems. • Medicines for stomach and bowel related problems - such as domperidone, metoclopromide or bethanechol Pregnancy and breastfeeding Talk to your doctor before taking this medicine if • You are pregnant, might become pregnant or think you may be pregnant • You are breast-feeding or planning to breast feed. This is because small amounts may pass into mothers’ milk. Breastfeeding while using oxybutynin is therefore not recommended. 2

Ask your doctor or pharmacist for advice before taking any medicine if you are pregnant or breastfeeding. Driving and using machines You may feel drowsy or have blurred vision while you are taking this medicine. If this happens, do not drive or use any tools or machines. Important information about some of the ingredients of Cystrin Tablets This medicine contains: • Lactose: If you have been told by your doctor that you cannot tolerate or digest some sugars (have an intolerance to some sugars), talk to your doctor before taking this medicine. 3. How to take Cystrin Tablets Always take Cystrin Tablets exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. Taking this medicine • Take this medicine by mouth • Swallow the tablets with a glass of water • Do not give this medicine to children under 5 years old • If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor.

632307_NT. CYSTRIN ZTV 5 MG RL S1 GB. qxp_FORMAT 210x170mm-RL-DBL. qxd 08/04/16 16:39 Page2

^ You have an enlarged prostate gland ^ You have indigestion or heart burn caused by a ‘hiatus hernia’ (where part of your stomach pushes through the diaphragm) ^ You have a raised body temperature or fever ^ You will be taking this medicine in a hot climate Cystrin tablets can cause glaucoma (increased pressure in the eye) please contact your doctor immediately if you suffer any blurred vision, loss of vision or have any pain in the eye. Cystrin tablets may reduce the amount of saliva resulting in tooth decay or fungal infection of the mouth. If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Cystrin Tablets.

Adults • The usual starting dose is one 5mg tablet two or three times each day • Your doctor may decide to increase to the maximum dose of 5mg four times each day Elderly • The usual starting dose is one 3mg tablet twice each day • Your doctor may decide to increase this until you respond to the medicine Children (over 5 years) • The starting dose is one 3mg tablet twice each day • The usual dose is then one 5mg tablet twice each day • Your doctor may decide to increase this to one 5mg tablet two or three times each day • If you are giving it to a child to prevent bedwetting, give the last dose just before bedtime If you take more Cystrin Tablets than you should If you take more Cystrin Tablets than you should, tell a doctor or go to a hospital casualty department straight away. Take the medicine pack with you. This is so the doctor knows what you have taken.

Taking too many Cystrin Tablets can be very dangerous. You may become very restless or excited, flush or get dizzy or lightheaded. Your heart beat may become very fast, uneven or forceful. You may get breathing problems or numbness or go into a coma. If you forget to take Cystrin Tablets If you forget a dose, take it as soon as you remember it. However, if it is nearly time for the next dose, skip the missed dose. Do not take a double dose to make up for a forgotten dose. If you stop taking Cystrin Tablets Keep taking Cystrin Tablets until your doctor tells you to stop. Do not stop taking Cystrin Tablets just because you feel better. 4. Possible side effects Like all medicines, Cystrin Tablets can cause side effects, although not everybody gets them. Children are at higher risk of the effects. Stop taking Cystrin Tablets and see a doctor or go to a hospital right away if: Frequency unknown • You have an allergic reaction. The signs may include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue. • You feel reduced sweating, leading to overheating in hot environments 3

Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days: Very common (affects more than 1 in 10 people) • Constipation • Dry mouth • Feeling sick, being sick • Dry skin • Headache • Somnolence (feeling drowsy or sleepy) • Dizziness • Blurring of vision Common (affects 1 to 10 people in a 100) • Dry eyes • Diarrhoea • Vomiting • Flushing especially in children • Confusion Uncommon (affects 1 to 10 people in a 1,000) • Stomach pain • Loss of appetite (anorexia) • Difficulty in swallowing (dysphagia) Frequency unknown • Increased pressure in the eyes, sometimes sudden and painful with blurred vision or loss of vision (glaucoma), enlargement of the pupil of the eye • Indigestion or heartburn (acid reflux) • Urinary tract infection • Increased, rapid or irregular heartbeat (palpitations) • Heat stroke • Difficulty passing water (urine)

632307_NT. CYSTRIN ZTV 5 MG RL S1 GB. qxp_FORMAT 210x170mm-RL-DBL. qxd 08/04/16 16:39 Page3

How much to take Your doctor will decide the dose appropriate for you.

after EXP. The expiry date refers to the last day of that month. Store below 30°C. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow card Scheme at: www. mhra. gov. uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.

What Cystrin Tablets looks like and contents of the pack • Cystrin® 5mg Tablets are pale blue round tablets with OXB5 on one side and a break line on the other side. Supplied in blisters of 84 tablets.

5. How to store Cystrin Tablets Keep this medicine in a safe place where children cannot see or reach it. Do not use Cystrin Tablets after the expiry date which is stated on the label or carton

This leaflet was last revised in April 2016. ‘Zentiva’ is a registered trademark © 2016 Zentiva

6. Further Information What Cystrin Tablets contain • Each tablet contains 5mg of the active substance oxybutynin hydrochloride • The other ingredients are lactose, microcrystalline cellulose, calcium stearate and indigo carmine aluminium lake (E132)

Marketing Authorisation Holder and Manufacturer Marketing Authorisation Holder Zentiva, One Onslow Street, Guildford, Surrey, GU1 4YS, UK Manufacturer Sanofi Winthrop Industrie, 30-36 avenue Gustave Eiffel, 37000 Tours, France 4

This leaflet does not contain all the information about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist.

632307_NT. CYSTRIN ZTV 5 MG RL S1 GB. qxp_FORMAT 210x170mm-RL-DBL. qxd 08/04/16 16:39 Page4

• Agitation • Anxiety • Becoming dependent on Cystrin • Feeling excessively suspicious and distrustful of others (paranoia) • Seeing or hearing things that are not there (hallucinations) • Drowsiness • Nightmares • Fits (convulsions) • Depression • Itchy, lumpy rash (Urticaria) • Absence of sweating (hypohidrosis) • Skin that is more sensitive to the sun (photosensitivity) • Abnormal bloating/swelling together with pain and feeling or being sick (pseudo-obstruction)

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



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Ciplox is used to treat different types of bacterial infections. It may also be used to prevent or slow anthrax after exposure.

Take Cipro exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take Cipro with a full glass of water (8 ounces). Drink several extra glasses of fluid each day while you are taking this medicine. Cipro may be taken with or without food, but take it at the same time each day. Shake the oral suspension (liquid) for at least 15 seconds just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

When taking the Cipro oral liquid, swallow it without chewing the medicine beads you may notice in the liquid.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time. Do not take Cipro with dairy products such as milk or yogurt, or with calcium-fortified juice. You may eat or drink these products as part of a regular meal, but do not use them alone when taking Cipro. They could make the medication less effective.

Take Cipro for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cipro will not treat a viral infection such as the common cold or flu.

Store Cipro at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

If you missed a dose - take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Take exactly as prescribed by your Health Provider.

Store this medicine at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

You should not use Ciplox if you are taking tizanidine (Zanaflex), if you have a history of myasthenia gravis, or if you are allergic to ciprofloxacin or similar antibiotics such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), and others.

Before taking Ciplox, tell your doctor if you have a heart rhythm disorder, kidney or liver disease, joint problems, diabetes, muscle weakness or trouble breathing, a condition called pseudotumor cerebri, a history of seizures, a history of head injury or brain tumor, low levels of potassium in your blood, a personal or family history of Long QT syndrome, or if you have ever had an allergic reaction to an antibiotic.

Do not take Ciplox with dairy products such as milk or yogurt, or with calcium-fortified juice. Avoid taking antacids, vitamin or mineral supplements, sucralfate (Carafate), or didanosine (Videx) powder or chewable tablets within 6 hours before or 2 hours after you take Ciplox. Ciprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. Stop taking Ciplox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions.

You should NOT take Ciplox if:

you are also taking tizanidine (Zanaflex);

you have a history of myasthenia gravis; or

you are allergic to ciprofloxacin or similar medications such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), ofloxacin (Floxin), norfloxacin (Noroxin), and others.

To make sure you can safely take Ciplox, tell your doctor if you have any of these other conditions:

heart rhythm disorder, especially if you take quinidine (Quin-G), disopyramide (Norpace), bretylium (Bretylol), procainamide (Pronestyl, Procan SR), amiodarone (Cordarone, Pacerone), or sotalol (Betapace);

a history of head injury or brain tumor;

a condition called pseudotumor cerebri (high pressure inside the skull that may cause headaches, vision loss, or other symptoms);

a history of allergic reaction to an antibiotic;

joint problems;

kidney or liver disease;

epilepsy or seizures;

diabetes;

muscle weakness or trouble breathing;

low levels of potassium in your blood (hypokalemia); or

a personal or family history of Long QT syndrome.

FDA pregnancy category C. It is not known whether Ciplox will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using it. Ciprofloxacin passes into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Ciplox may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking Ciplox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions. Do not share Ciplox with another person (especially a child), even if they have the same symptoms you have.

Get emergency medical help if you have any of these signs of an allergic reaction to Ciplox: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Ciplox and call your doctor at once if you have a serious side effect such as:

severe dizziness, fainting, fast or pounding heartbeats;

sudden pain, snapping or popping sound, bruising, swelling, tenderness, stiffness, or loss of movement in any of your joints;

diarrhea that is watery or bloody;

confusion, hallucinations, depression, unusual thoughts or behavior;

seizure (convulsions);

severe headache, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;

pale or yellowed skin, dark colored urine, fever, weakness;

urinating less than usual or not at all;

easy bruising or bleeding;

numbness, tingling, or unusual pain anywhere in your body;

the first sign of any skin rash, no matter how mild; or

severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects:

nausea, vomiting;

dizziness or drowsiness;

blurred vision;

feeling nervous, anxious, or agitated; or

sleep problems (insomnia or nightmares).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

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Diclofenac colestyramine (a derivative of Diclofenac) is reported as an ingredient of Artren in the following countries:

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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Joined 01-12-08. id: 1472936, Profile Updated: 02-04-08

Author has written 2 stories for Harry Potter.

I am a writer, an artist, like many in the world, just trying to have fun and let others have fun from my their (the artists) work. I HATE endings, I like stories that go on and on and on, or have sequals. I am trying to make my stories as long as possible, or have sequals. I like to beleive in the unbeleivable, it give meaning to an otherwise dull existance. I hope to write and draw and do as much art as is possible in my lifetime and hope to become famous so that many people will be able to enjoy the art i create, I hope to become rich so that I can make the world a better and more interesting place by building museums for modern artists, young artists aspiring artists, and art that is based on fantasy or horror etc. I hope to donate to charaties or start a place where the poor can make their living by learning to use natural talents in art or labor or science (etc). I would like to start a B and B exclusively for artists with each cabin based on a type of art, music wriiting painting or otherwise. I have many dreams, and I doubt many will come true, as for the moment I just want to have fun, be recognised, do well enough in school, and share that the secret to everything is 42. (yay towels!)

I love science, and explosions, I love thermite, and rocks, I love animals and nature and I try to respect others. I hate people who do not see the beauty in the contradiction of a simple flower, or the whole of the universe, I hate when I cannot describe my ideas, I hate forgetting ideas, I hate having to type out the ideas and then have them ont come out right, I hate ignorance and the inability to accept that not everything is what it seems, I hate predijuce, though I will not deny that in some way i am probably predijuced too, probably against the human race, I hate what we are doing to the planet, I hate petty power struggles, but I still find them amusing, I hate not understanding my emotions or being unable to explain them. I love battle but I hate how it has lost it's honor, I love being sneaky but I hate the ways it is used today to hide scandal and torture, if you're going to torture someone have a valid reason, and tell everybody! If your people do not like it then it is your problem but at least you were open (fuck you George Bush!). I hate people trying to turn me into something I'm not, I hate losing concentration, I hate my bad memory, I hate not being able to study, I hate PST, I hate people being sceptical about an idea just because they've never heard of it before. I love the utter beauty of life and the horror that it brings with the contradictory beauty and happiness along side it. I love all the things I hate because it shows that I am alive and have opinions, and because they, in their own small way are good because it shows existance and the contradictory opposites that the human mind also entails, I hate everything I love for the same reason. I love confusing people with my overly large thoughts, and am amused when people try to insult me but can't because they don't understand all the big words I just used. I can be amused by almost anything.

I hate getting cramps in my wrist from typing too much in odd positions. (OOOOOOWW!)

oh and I LOOOOVE Snape. squeee!

Sort: Category. Published. Updated. Title. Words. Chapters. Reviews. Status .

Beetlejuice is the magic in Lydia's life. 10th in Will's 13 Days of Halloween series for Jack. Het.

Beetlejuice - Rated: M - English - Romance/Friendship - Chapters: 1 - Words: 5,147 - Reviews: 1 - Favs: 25 - Follows: 3 - Published: 12/25/2010 - Lydia D. Beetlejuice - Complete

Beetlejuice reflects on his lost oppurtunity with Lydia. He manages to find a way back to her, but fate conspires to keep them apart. COMPLETE

Beetlejuice - Rated: T - English - Angst - Chapters: 14 - Words: 26,165 - Reviews: 101 - Favs: 26 - Follows: 18 - Updated: 2/9/2009 - Published: 8/9/2007 - Complete

Sequel to 'Lydia was late.' No one ever said it would be easy. This was Beetlejuice, after all. But with the choices they made that have led them here, will they be allowed to enjoy their new-found happiness? Or will 'choices' have to be made again?

Beetlejuice - Rated: M - English - Romance/Angst - Chapters: 13 - Words: 53,659 - Reviews: 50 - Favs: 70 - Follows: 18 - Updated: 9/1/2008 - Published: 8/5/2008 - Complete

A dark and pleasant little what if. What if it wasn't Lydia who'd agreed to marry Beetlejuice to save the Maitland's, but her mother? What if, a generation later, Lydia finds his ring, and puts it on? Not a happy, fluffy story. Old grudges die hard.

Beetlejuice - Rated: M - English - Angst/Romance - Chapters: 13 - Words: 66,512 - Reviews: 64 - Favs: 126 - Follows: 21 - Updated: 8/2/2008 - Published: 7/22/2008 - Complete

Lydia needs some time away, and Beetlejuice isn't very happy with the arrangement. As the old saying goes, distance makes us wise. BJxLydia. Cartooniverse. Rated T for mild cursing.

Beetlejuice - Rated: T - English - Romance - Chapters: 11 - Words: 6,375 - Reviews: 20 - Favs: 24 - Follows: 4 - Updated: 6/21/2008 - Published: 6/19/2008 - Complete

Though she knows she should be wary. Set in the cartoonverse, a look at how Beetlejuice and Lydia's relationship seems from the outside. T for suggestiveness.

Beetlejuice - Rated: T - English - Romance/Friendship - Chapters: 1 - Words: 1,855 - Reviews: 21 - Favs: 52 - Follows: 10 - Published: 11/17/2007 - Complete

Explaining himself. has never been one of Beetlejuice's strong suits. But if you really listen to him, it makes sense, in a roundabout way. Cartoonverse, implied onesided BJ/LD.

Beetlejuice - Rated: K+ - English - Humor/Romance - Chapters: 1 - Words: 379 - Reviews: 21 - Favs: 24 - Follows: 2 - Published: 9/12/2007 - [Beetlejuice, Lydia D.] - Complete

A sequel to 'Welcome to The Neitherworld'. Lydia and Beetlejuice start to become friends, perhaps a little more then friends.

Beetlejuice - Rated: M - English - Supernatural - Chapters: 8 - Words: 11,523 - Reviews: 15 - Favs: 21 - Follows: 13 - Updated: 2/11/2007 - Published: 8/24/2006 - Complete

Lydia is all alone on Halloween night, and Betelgeuse is finally back in the land of the unliving after three years' punishment for his misdeeds. Whatever will happen? Movieverse, BeejLyds.

Beetlejuice - Rated: K+ - English - Supernatural/Romance - Chapters: 1 - Words: 7,442 - Reviews: 14 - Favs: 57 - Follows: 6 - Published: 10/18/2006 - Complete

Set a little while after the movie, perhaps a month or two. Kind of mixes in the cartoon. Connecting the movie to the cartoon, only Lydia is 17 years old. FINISHED

Beetlejuice - Rated: M - English - Supernatural/Romance - Chapters: 6 - Words: 9,512 - Reviews: 32 - Favs: 34 - Follows: 14 - Updated: 1/10/2006 - Published: 10/4/2005

Dumbledore's thoughts one night as he walks along the corridors of Hogwarts. Takes place before Book 5.

Harry Potter - Rated: K+ - English - Chapters: 1 - Words: 2,524 - Reviews: 58 - Favs: 17 - Published: 7/13/2001 - Complete

Sort: Category. Published. Updated. Title. Words. Chapters. Reviews. Status.

Before Harry Potter came to Hogwarts, Snape was still teaching. What type of kids did he put up with, did he have more of a free reign, did students dissapear, did Dumbledore notice. Maybe. Although it is AU I try to follow demeanor as closley as I can

Harry Potter - Rated: M - English - Horror/Adventure - Chapters: 6 - Words: 15,381 - Reviews: 4 - Favs: 3 - Follows: 2 - Updated: 4/23/2011 - Published: 1/15/2008 - Severus S.

One year after the defeat of Voldemort we find Ron and Hermione are married; Harry and Ginny engaged, and the trio has just received letters of approval for Auror testing. Harry, however, has also gotten a curious letter saying Dumbledore wants to see him

Harry Potter - Rated: M - English - Adventure - Chapters: 7 - Words: 24,142 - Reviews: 1 - Favs: 1 - Follows: 3 - Updated: 2/1/2009 - Published: 1/15/2008 - Harry P.



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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Tinidazole is used for treating certain parasitic and bacterial infections. Tinidazole is an antiprotozoal and antibiotic. It works by killing sensitive parasites and bacteria.

Use Tinidazole as directed by your doctor.

Take Tinidazole by mouth with food.

If you have trouble swallowing the tablets, check with your doctor or pharmacist.

If you take cholestyramine, do not take it at the same time you take Tinidazole. Talk with your doctor about how you should take cholestyramine with Tinidazole.

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Store Tinidazole at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tinidazole out of the reach of children and away from pets.

Do NOT use Tinidazole if:

you are allergic to any ingredient in Tinidazole or to other nitroimidazole medicines (metronidazole)

you have the blood disease porphyria

you are in your first 3 months of pregnancy

you are taking astemizole, busulfan, cisapride, or terfenadine

you have taken disulfiram within the past 2 weeks.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Tinidazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have nerve, brain, or blood problems; a yeast infection; or a history of seizures or liver problems

if you are undergoing dialysis.

Some medicines may interact with Tinidazole. Tell your health care provider if you are taking any other medicines, especially any of the following:

Azole antifungals (eg, ketoconazole) or cimetidine because they may increase the risk of Tinidazole's side effects

Barbiturates (eg, phenobarbital), phenytoin, or rifampin because they may decrease Tinidazole's effectiveness

Anticoagulants (eg, warfarin), astemizole, busulfan, cisapride, cyclosporine, fluorouracil, lithium, macrolide immunosuppressants (eg, tacrolimus), sulfonylureas (eg, glipizide), or terfenadine because their actions and the risk of their side effects may be increased

Disulfiram because side effects, such as mental or mood changes, may occur

Oral contraceptives (birth control pills) because their effectiveness may be decreased by Tinidazole.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tinidazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Tinidazole may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Tinidazole with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Avoid drinking alcohol or taking products that contain alcohol while taking Tinidazole and for 3 days after the last dose.

Tinidazole only works against bacteria and parasites; it does not treat viral infections (eg, the common cold).

Be sure to use Tinidazole for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria or parasites could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Tinidazole may discolor or darken the urine. This is normal and not a cause for concern.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Tinidazole. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Tell your doctor or dentist that you take Tinidazole before you receive any medical or dental care, emergency care, or surgery.

Tinidazole may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Tinidazole.

Lab tests, including blood cell counts, may be performed while you use Tinidazole. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Tinidazole with extreme caution in children younger 3 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: Tinidazole may cause harm to the fetus. Tinidazole should not be used during the first trimester of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tinidazole while you are pregnant. Tinidazole is found in breast milk. Do not breast-feed while taking Tinidazole and for 3 days after you have taken the last dose.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; general body discomfort; headache; loss of appetite; metallic/bitter taste in mouth; nausea; stomach pain; tiredness; vomiting; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal skin sensations (prickling, tingling); depression; fever, chills, or persistent sore throat; hoarseness; irregular heartbeat; numbness or loss of feeling in the hands or feet; pounding in the chest; red, swollen, blistered, or peeling skin; seizures; shortness of breath; unusual bruising or bleeding ; vaginal irritation or discharge.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Tinidazole is used for treating certain parasitic and bacterial infections. Tinidazole is an antiprotozoal and antibiotic. It works by killing sensitive parasites and bacteria.

Use Tinidazole as directed by your doctor.

Take Tinidazole by mouth with food.

If you have trouble swallowing the tablets, check with your doctor or pharmacist.

If you take cholestyramine, do not take it at the same time you take Tinidazole. Talk with your doctor about how you should take cholestyramine with Tinidazole.

If more than one dose of Tinidazole is required, continue using Tinidazole for the full course of treatment in order to clear up your infection completely, even if you feel better in a few days. Do not miss any dose.

If you miss a dose of Tinidazole, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tinidazole.

Store Tinidazole at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tinidazole out of the reach of children and away from pets.

Do NOT use Tinidazole if:

you are allergic to any ingredient in Tinidazole or to other nitroimidazole medicines (metronidazole)

you have the blood disease porphyria

you are in your first 3 months of pregnancy

you are taking astemizole, busulfan, cisapride, or terfenadine

you have taken disulfiram within the past 2 weeks.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Tinidazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have nerve, brain, or blood problems; a yeast infection; or a history of seizures or liver problems

if you are undergoing dialysis.

Some medicines may interact with Tinidazole. Tell your health care provider if you are taking any other medicines, especially any of the following:

Azole antifungals (eg, ketoconazole) or cimetidine because they may increase the risk of Tinidazole's side effects

Barbiturates (eg, phenobarbital), phenytoin, or rifampin because they may decrease Tinidazole's effectiveness

Anticoagulants (eg, warfarin), astemizole, busulfan, cisapride, cyclosporine, fluorouracil, lithium, macrolide immunosuppressants (eg, tacrolimus), sulfonylureas (eg, glipizide), or terfenadine because their actions and the risk of their side effects may be increased

Disulfiram because side effects, such as mental or mood changes, may occur

Oral contraceptives (birth control pills) because their effectiveness may be decreased by Tinidazole.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tinidazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Tinidazole may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Tinidazole with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Avoid drinking alcohol or taking products that contain alcohol while taking Tinidazole and for 3 days after the last dose.

Tinidazole only works against bacteria and parasites; it does not treat viral infections (eg, the common cold).

Be sure to use Tinidazole for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria or parasites could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Tinidazole may discolor or darken the urine. This is normal and not a cause for concern.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Tinidazole. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Tell your doctor or dentist that you take Tinidazole before you receive any medical or dental care, emergency care, or surgery.

Tinidazole may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Tinidazole.

Lab tests, including blood cell counts, may be performed while you use Tinidazole. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Tinidazole with extreme caution in children younger 3 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: Tinidazole may cause harm to the fetus. Tinidazole should not be used during the first trimester of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tinidazole while you are pregnant. Tinidazole is found in breast milk. Do not breast-feed while taking Tinidazole and for 3 days after you have taken the last dose.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; general body discomfort; headache; loss of appetite; metallic/bitter taste in mouth; nausea; stomach pain; tiredness; vomiting; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal skin sensations (prickling, tingling); depression; fever, chills, or persistent sore throat; hoarseness; irregular heartbeat; numbness or loss of feeling in the hands or feet; pounding in the chest; red, swollen, blistered, or peeling skin; seizures; shortness of breath; unusual bruising or bleeding ; vaginal irritation or discharge.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Mefenamic Acid Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Fenamin

mefenamic acid

GENERIC NAME(S): MEFENAMIC ACID

Warnings

Nonsteroidal anti-inflammatory drugs (including mefenamic acid ) may rarely increase the risk for a (sometimes fatal) heart attack or stroke. This effect does not apply to low-dose aspirin. (See Drug Interactions section.) The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking. family history of heart disease. or conditions such as high blood pressure or diabetes ), or with longer use. This drug should not be taken right before or after heart bypass surgery (CABG). Also, this drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This bleeding can occur without warning symptoms at any time during treatment.

Stop taking this medication and seek immediate medical attention if you notice any of the following rare but very serious side effects: chest pain. severe dizziness. trouble breathing. weakness on one side of the body, sudden vision changes, slurred speech, black stools, persistent stomach /abdominal pain. vomit that looks like coffee grounds. (See also Precautions section.)

Talk with your doctor or pharmacist about the risks and benefits of treatment with this medication.

Uses

Mefenamic acid is used for the short-term treatment of mild to moderate pain from various conditions. It is also used to decrease pain and blood loss from menstrual periods.

Mefenamic acid is known as a nonsteroidal anti-inflammatory drug (NSAID).

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat gout attacks.

How to use mefenamic acid

Read the Medication Guide provided by your pharmacist before you start using mefenamic acid and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth. usually 4 times a day with a full glass of water (8 ounces or 240 milliliters) or as directed by your doctor. Do not lie down for at least 10 minutes after taking this drug. If stomach upset occurs, take this medication with food or milk. Do not take mefenamic acid with antacids unless directed by your doctor. Certain antacids may change the amount of mefenamic acid absorbed by the body.

Dosage is based on your medical condition and response to therapy. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose, take it more frequently, or take it for a longer time than prescribed. This medication usually should not be taken for more than 7 days at a time.

If you are taking this drug on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medicine may not work as well.

If you are using this medication for painful periods, take your first dose as soon as your period starts or pain begins. Usually, you will only need to take it for the first 2 to 3 days of your period.

Inform your doctor if your pain persists or worsens or if you develop new symptoms.

Side Effects

See also Warning section.

Upset stomach. nausea. heartburn. dizziness, drowsiness, diarrhea. and headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if any of these unlikely but serious side effects occur: fainting. persistent/severe headache. hearing changes (e. g. ringing in the ears ), fast/pounding heartbeat, mental/mood changes, stomach pain, difficult/painful swallowing, swelling of the ankles /feet/hands, sudden/unexplained weight gain. vision changes, unusual tiredness.

Stop taking mefenamic acid and tell your doctor right away if any of these rare but very serious side effects occur: easy bruising/bleeding, signs of infection (e. g. fever, persistent sore throat ), unexplained stiff neck. change in the amount/color of urine.

This drug may rarely cause serious, possibly fatal liver disease. If you notice any of the following rare but very serious side effects, stop taking mefenamic acid and consult your doctor or pharmacist right away: persistent nausea/vomiting, severe stomach/abdominal pain, weakness, dark urine, yellowing eyes /skin .

A very serious allergic reaction to this drug is rare. However, stop taking mefenamic acid and immediately seek medical attention if you notice any of the following symptoms of a serious allergic reaction. rash/blisters. itching /swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking mefenamic acid, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (e. g. ibuprofen, naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs, severe kidney disease, recent heart bypass surgery (CABG), active bleeding/sores in stomach/intestines (ulcer, gastrointestinal bleeding).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, bleeding/clotting problems, blood disorders (e. g. anemia), high blood pressure, diabetes, heart disease (e. g. history of heart attack), liver disease, growths in the nose (nasal polyps), obesity, tobacco use, history of stomach/intestine/esophagus problems (e. g. bleeding, ulcers, recurring heartburn), stroke, swelling of the ankles/feet/hands.

Kidney problems can sometimes occur with the use of NSAID medications, including mefenamic acid. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have any unusual change in the amount of urine.

Before having surgery, tell your doctor or dentist that you are using this medication.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, or sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, caution is advised when using this drug in the elderly because they may be more sensitive to its side effects, especially stomach bleeding and kidney problems.

Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as valsartan, losartan), cidofovir, corticosteroids (e. g. prednisone), fluconazole, ketorolac, lithium, methotrexate, "water pills" (diuretics such as furosemide).

This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as celecoxib or ibuprofen). These drugs are similar to mefenamic acid and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

This medication may interfere with certain laboratory tests (e. g. urine bile test), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe stomach pain, vomit that looks like coffee grounds, extreme drowsiness, slow/shallow breathing, seizures.

Notes

Do not share this drug with others.

Laboratory and/or medical tests (e. g. blood pressure, complete blood count, liver and kidney function tests) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you are taking this drug on a regular schedule (not "as needed") and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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What is fluoxetine?

Fluoxetine is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Fluoxetine affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms.

Fluoxetine is used to treat major depressive disorder, bulimia nervosa (an eating disorder) obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder (PMDD).

Fluoxetine is sometimes used together with another medication called olanzapine (Zyprexa) to treat depression caused by bipolar disorder (manic depression). This combination is also used to treat depression after at least 2 other medications have been tried without successful treatment of symptoms.

Fluoxetine may also be used for purposes other than those listed in this medication guide.

Precautions

Do not use fluoxetine if you are using any of the following drugs:

pimozide (Orap);

thioridazine (Mellaril); or

an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam).

Serious and sometimes fatal reactions can occur when these medicines are taken with fluoxetine. You must wait at least 14 days after stopping an MAO inhibitor before you can take fluoxetine. You must wait 5 weeks after stopping fluoxetine before you can take thioridazine (Mellaril) or an MAOI.

Before taking fluoxetine, tell your doctor if you are allergic to any drugs, or if you have:

cirrhosis of the liver;

kidney disease;

diabetes;

seizures or epilepsy;

bipolar disorder (manic depression); or

a history of drug abuse or suicidal thoughts.

If you have any of these conditions, you may not be able to use fluoxetine, or you may need a dosage adjustment or special tests.

You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking fluoxetine, do not stop taking the medication without first talking to your doctor.

Fluoxetine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give fluoxetine to anyone younger than 18 years old without a doctor’s advice. Fluoxetine is the only antidepressant that is FDA-approved for use in children with depression.

Avoid drinking alcohol, which can increase some of the side effects of fluoxetine.

Fluoxetine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety). They can add to sleepiness caused by fluoxetine.

Instructions

Seek emergency medical attention if you think you have taken too much of this medication. Overdose may cause nausea, vomiting, fever, sleepiness, rapid or uneven heartbeat, confusion, fainting, seizures, or coma.

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose.

If you miss a dose of Prozac Weekly, take the missed dose as soon as you remember and take the next dose 7 days later. However, if it is almost time for the next regularly scheduled weekly dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

severe blistering, peeling, and red skin rash;

very stiff (rigid) muscles, high fever, sweating, fast or uneven heartbeats, tremors, overactive reflexes;

nausea, vomiting, diarrhea, loss of appetite, feeling unsteady, loss of coordination; or

headache, trouble concentrating, memory problems, weakness, confusion, hallucinations, fainting, seizure, shallow breathing or breathing that stops.

Less serious side effects may include:

cold symptoms such as stuffy nose, sneezing, sore throat;

drowsiness, dizziness, feeling nervous;

mild nausea, upset stomach, constipation;

increased appetite, weight changes;

sleep problems (insomnia);

decreased sex drive, impotence, or difficulty having an orgasm; or

dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Interactions

Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin and NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with fluoxetine may cause you to bruise or bleed easily.

Before taking fluoxetine, tell your doctor if you are using any of the following medicines:

alprazolam (Xanax);

clozapine (Clozaril, Fazaclo);

digitoxin (Crystodigin);

flecainide (Tambocor);

haloperidol (Haldol);

seizure medication such as phenytoin (Dilantin) or carbamazepine (Tegretol);

tryptophan (also called L-tryptophan);

vinblastine (Velban);

a blood thinner such as warfarin (Coumadin);

almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig); or

any other antidepressants such as amitriptyline (Elavil), escitalopram (Lexapro), imipramine (Tofranil), sertraline (Zoloft), and others.

This list is not complete and there may be other drugs that can interact with fluoxetine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

Prozac, Prozac Weekly, Rapiflux, Sarafem, fluoxetine, and Selfemra

Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

Last updated: September 20, 2016

What is the most important information I should know about fluoxetine?

Do not take fluoxetine together with pimozide (Orap), thioridazine (Mellaril), or a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking fluoxetine, do not stop taking the medication without first talking to your doctor.

Warning

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.



Buy Online Fluoxetine Report For Patients Like You, Moltoben

Tetracycline - Fda Prescribing Information, Side Effects And Uses, Tetraciclina

Tetracycline

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Tetracycline hydrochloride and other antibacterial drugs, Tetracycline hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Tetracycline Description

Tetracycline is a yellow, odorless, crystalline powder. Tetracycline is stable in air but exposure to strong sunlight causes it to darken. Its potency is affected in solutions of pH below 2 and is rapidly destroyed by alkali hydroxide solutions. Tetracycline is very slightly soluble in water, freely soluble in dilute acid and in alkali hydroxide solutions, sparingly soluble in alcohol, and practically insoluble in chloroform and in ether. The chemical name for Tetracycline hydrochloride is 4 - (Dimethylamino)1,4,4a,5,5a,6,11,12a - octahydro - 3,6,10,12, - 12a - pentahydroxy - 6 - methyl - 1,11 - dioxo2 - naphthacenecar - boxamide monohydrochloride.

Each capsule, for oral administration, contains Tetracycline hydrochloride USP, 250 mg or 500 mg.

Inactive Ingredients: Lactose, magnesium stearate, and sodium lauryl sulfate.

The 250 mg capsule shell contains D&C yellow no. 10, FD&C yellow no. 6, gelatin, sodium lauryl sulfate, and titanium dioxide. It may also contain benzyl alcohol, butylparaben, D&C red no. 22, edetate calcium disodium, methylparaben, propylparaben, silicon dioxide, and sodium propionate.

The imprinting ink for the 250 mg capsule contains pharmaceutical glaze, and synthetic black iron oxide. It may also contain D&C yellow no. 10 (aluminum lake), dimethylpolysiloxane, distilled water, ethylene glycol monoethyl ether, FD&C blue no. 1 (aluminum lake), FD&C blue no. 2 (aluminum lake), FD&C red no. 40 (aluminum lake), lecithin, n-butyl alcohol, propylene alcohol, and SDA-3A alcohol.

The 500 mg capsule shell contains D&C yellow no. 10, FD&C blue no.1, FD&C red no. 40, gelatin, sodium lauryl sulfate, and titanium dioxide. It may also contain benzyl alcohol, butylparaben, edetate calcium disodium, FD&C yellow no. 6, methylparaben, propylparaben, silicon dioxide, and sodium propionate.

The imprinting ink for the 500 mg capsule contains titanium dioxide. It may also contain dimethyl polysiloxane, distilled water, ethyl alcohol, ethylene glycol monoethyl ether, pharmaceutical glaze, pharmaceutical shellac, and soya lecithin.

Its structural formula is as follows:

CLINICAL PHARMACOLOGY

Tetracyclines are readily absorbed and are bound to plasma proteins in varying degrees. They are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations in a biologically active form.

Microbiology

Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis. Tetracycline is active against a wide range of gram-negative and gram-positive organisms. The drugs in the Tetracycline class have closely similar antimicrobial spectra, and cross-resistance among them is common.

While in vitro studies have demonstrated the susceptibility of most strains of the following microorganisms, clinical efficacy for infections other than those included in the INDICATIONS AND USAGE section has not been documented.

Gram-negative Bacteria

Neisseria gonorrhoeae Haemophilus ducreyi Haemophilus influenzae Yersinia pestis (formerly Pasteurella pestis) Francisella tularensis (formerly Pasteurella tularensis) Vibrio cholera (formerly Vibrio comma) Bartonella bacilliformis Brucella species

Because many strains of the following groups of gram-negative microorganisms have been shown to be resistant to Tetracyclines, culture and susceptibility testing are recommended:

Escherichia coli Klebsiella species Enterobacter aerogenes Shigella species Acinetobacter species (formerly Mima species and Herellea species) Bacteroides species

Gram-positive Bacteria

Because many strains of the following groups of gram-positive microorganisms have been shown to be resistant to Tetracycline, culture and susceptibility testing are recommended. Up to 44 percent of strains of Streptococcus pyogenes and 74 percent of Streptococcus faecalis have been found to be resistant to Tetracycline drugs. Therefore, Tetracyclines should not be used for streptococcal disease unless the organisms have been demonstrated to be susceptible.

Streptococcus pyogenes Streptococcus pneumoniae Enterococcus group (Streptococcus faecalis and Streptococcus faecium) Alpha-hemolytic Streptococci (viridans group)

Other microorganisms

Chlamydia psittaci Chlamydia trachomatis Ureaplasma urealyticum Borrelia recurrentis Treponema pallidum Treponema pertenue Clostridia species Fusobacterium fusiforme Actinomyces species Bacillus anthraxis Propionibacterium acnes Entamoeba species Balantidium coli

Susceptibility Testing

Quantitative methods are used to determine antimicrobial minimal inhibitory concentrations (MICs). These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds. The MICs should be determined using a standardized procedure. Standardized procedures are based on a dilution method (Ref1, Ref3, Ref4) (broth or agar) or equivalent with standardized inoculum concentrations and standardized concentrations of Tetracycline powder. The MIC values should be interpreted according to the following criteria:

For testing Enterobacteriaceae, Acinetobacter species, Staphylococcus spp. Enterococcus spp. and Vibrio cholerae :

A report of “Susceptible” indicates that the pathogen is likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable. A report of “Intermediate” indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of drug can be used. This category also provides a buffer zone which prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of “Resistant” indicates that the pathogen is not likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable; other therapy should be selected.

Standardized susceptibility test procedures require the use of laboratory control microorganisms to control the technical aspects of the laboratory procedures. Standard Tetracycline powder should provide the following MIC values:

MIC Range (mcg/mL)

Escherichia coli ATCC 25922

Enterococcus faecalis ATCC 29212

Staphylococcus aureus ATCC 29213

Pseudomonas aeruginosa ATCC 27853

Haemophilus influenzae ATCC 49247

Streptococcus pneumoniae ATCC 49619

Neisseria gonorrhoeae ATCC 49226

Quantitative methods that require measurement of zone diameters also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. One such standardized procedure ( Ref2, Ref3, Ref4 ), uses paper disks impregnated with 30 mcg Tetracycline to test the susceptibility of microorganisms to Tetracycline.

Reports from the laboratory providing results of the standard single-disk susceptibility test with a 30 mcg Tetracycline disk should be interpreted according to the following criteria:

For testing Enterobacteriaceae, Acinetobacter spp. and Vibrio cholera:

Zone Diameter (mm)

These interpretative standards are applicable only to disk diffusion testing using Mueller-Hinton agar adjusted with 5% sheep blood and a 30 mcg Tetracycline disk.

As with standardized dilution techniques, diffusion methods require the use of laboratory control microorganisms that are used to control the technical aspects of the laboratory procedures. For the diffusion technique, the 30 mcg Tetracycline disk should provide the following zone diameters in these laboratory test quality control strains:

Zone Diameter Range (mm)

Escherichia coli ATCC 25922

Staphylococcus aureus ATCC 25923

Haemophilus influenzae ATCC 49247

Neisseria gonorrhoeae ATCC 49226

Streptococcus pneumoniae ATCC 49619

INDICATIONS AND USAGE

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Tetracycline hydrochloride capsules USP and other antibacterial drugs, Tetracycline hydrochloride capsules USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Tetracycline hydrochloride, USP is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the conditions listed below:

Upper respiratory tract infections caused by Streptococcus pyogenes. Streptococcus pneumoniae and Haemophilus influenzae. Note: Tetracycline should not be used for streptococcal disease unless the organism has been demonstrated to be susceptible.

Lower respiratory tract infections caused by Streptococcus pyogenes. Streptococcus pneumoniae. Mycoplasma pneumoniae (Eaton agent, and Klebsiella sp.)

Skin and soft tissue infections caused by Streptococcus pyogenes. Staphylococcus aureus . (Tetracyclines are not the drugs of choice in the treatment of any type of staphylococcal infections.)

Infections caused by rickettsia including Rocky Mountain spotted fever, typhus group infections, Q fever, rickettsialpox.

Psittacosis or ornithosis caused by Chlamydia P sittaci .

Infections caused by Chlamydia trachomatis such as uncomplicated urethral, endocervical, or rectal infections, inclusion conjunctivitis, trachoma and lymphogranuloma venereum.

Granuloma inquinale caused by Calymmatobacterium granulomatis .

Relapsing fever caused by Borrelia sp.

Bartonellosis caused by Bartonella bacilli formis .

Chancroid caused by Haemophilus ducreyi .

Tularemia caused by Francisella tularensis .

Plaque caused by Yersinia pestis .

Cholera caused by Vibrio cholerae .

Brucellosis caused by Brucella species (Tetracycline may be used in conjunction with an aminoglycoside).

Infections due to Campylobacter fetus .

As adjunctive therapy in intestinal amebiasis caused by Entamoeba histolytica .

Urinary tract infections caused by susceptible strains of Escherichia coli. Klebsiella. etc.

Other infections caused by susceptible gram-negative organisms such as E. coli. Enterobacter aerogenes, Shigella sp. Acinetobacter sp. Klebsiella sp. and Bacteroides sp.

In severe acne, adjunctive therapy with Tetracycline may be useful.

When penicillin is contraindicated, Tetracyclines are alternative drugs in the treatment of the following infections:

Syphilis and yaws caused by Treponema pallidum and pertenue. respectively,

Vincent’s infection caused by Fuso bacterium fusiforme ,

Infections caused by Neisseria gonorrhoeae ,

Anthrax caused by Bacillus anthracis ,

Infections due to Listeria monocytogenes ,

Actinomycosis caused by Actinomyces species,

Infections due to Clostridium species.

Contraindications

This drug is contraindicated in persons who have shown hypersensitivity to any of the Tetracyclines.

Warnings

THE USE OF DRUGS OF THE Tetracycline CLASS DURING TOOTH DEVELOPMENT (LAST HALF OF PREGNANCY, INFANCY AND CHILDHOOD TO THE AGE OF 8 YEARS) MAY CAUSE PERMANENT DISCOLORATION OF THE TEETH (YELLOW-GRAY-BROWN). This adverse reaction is more common during long-term use of the drugs but has been observed following repeated short-term courses. Enamel hypoplasia has also been reported. Tetracycline DRUGS, THEREFORE, SHOULD NOT BE USED IN THIS AGE GROUP UNLESS OTHER DRUGS ARE NOT LIKELY TO BE EFFECTIVE OR ARE CONTRAINDICATED.

All Tetracyclines form a stable calcium complex in any bone forming tissue. A decrease in fibula growth rate has been observed in premature infants given oral Tetracycline in doses of 25 mg/kg every six hours. This reaction was shown to be reversible when the drug was discontinued.

Results of animal studies indicate that Tetracyclines cross the placenta, are found in fetal tissues and can have toxic effects on the developing fetus (often related to retardation of skeletal development). Evidence of embryotoxicity has also been noted in animals treated early in pregnancy. If this drug is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Tetracycline drugs should not be used during pregnancy unless absolutely necessary.

If renal impairment exists, even usual oral or parenteral doses may lead to excessive systemic accumulation of the drug and possible liver toxicity. Under such conditions, lower than usual total doses are indicated, and, if therapy is prolonged, serum level determinations of the drug may be advisable.

Photosensitivity manifested by an exaggerated sunburn reaction has been observed in some individuals taking Tetracyclines. Patients apt to be exposed to direct sunlight or ultraviolet light should be advised that this reaction can occur with Tetracycline drugs. Treatment should be discontinued at the first evidence of skin erythema.

The antianabolic action of the Tetracyclines may cause an increase in BUN. While this is not a problem in those with normal renal function, in patients with significantly impaired renal function, higher serum levels of Tetracycline may lead to azotemia, hyperphosphatemia and acidosis.

PRECAUTIONS

General

As with other antibiotics, use of this drug may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, the antibiotic should be discontinued and appropriate therapy should be instituted.

All infections due to Group A beta - hemolytic streptococci should be treated for at least ten days.

Bulging fontanels in infants and benign intracranial hypertension in adults have been reported in individuals receiving Tetracyclines. These conditions disappeared when the drug was discontinued.

Incision and drainage or other surgical procedures should be performed in conjunction with antibiotic therapy, when indicated.

Prescribing Tetracycline in the absence of proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Information for Patients

Patients should be counseled that antibacterial drugs including Tetracycline should only be used to treat bacterial infections. They do not treat viral infections (e. g. the common cold). When Tetracycline is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Tetracycline or other antibacterial drugs in the future.

Laboratory Tests

In venereal diseases, when coexistent syphilis is suspected, dark field examinations should be done before treatment is started and the blood serology repeated monthly for at least four months.

In long-term therapy, periodic laboratory evaluation of organ systems, including hematopoietic, renal and hepatic studies, should be performed.

Drug Interactions

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving Tetracycline in conjunction with penicillin or other bactericidal antibiotics.

Because the Tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

The concurrent use of Tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.

Absorption of Tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and preparations containing iron, zinc, or sodium bicarbonate.

Concurrent use of Tetracycline may render oral contraceptives less effective.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term animal studies are currently being conducted to determine whether Tetracycline hydrochloride has carcinogenic potential.

Some related antibiotics (oxyTetracycline, minocycline) have shown evidence of oncogenic activity in rats.

In two in vitro mammalian cell assay systems (L 51784y mouse lymphoma and Chinese hamster lung cells), there was evidence of mutagenicity at Tetracycline hydrochloride concentrations of 60 and 10 mcg/mL, respectively.

Tetracycline hydrochloride had no effect on fertility when administered in the diet to male and female rats at a daily intake of 25 times the human dose.

Pregnancy

Pregnant women with renal disease may be more prone to develop Tetracycline-associated liver failure.

Labor and Delivery

The effect of Tetracyclines on labor and delivery is unknown.

Nursing Mothers

Because of the potential for serious adverse reaction in nursing infants from Tetracyclines, a decision should be made whether to discontinue the drug, taking into account the importance of the drug to the mother (see WARNINGS ).

Pediatric Use

ADVERSE REACTIONS

Gastrointestinal:

anorexia, nausea, epigastric distress, vomiting, diarrhea, glossitis, black hairy tongue, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region.

Rare instances of esophagitis and esophageal ulceration have been reported in patients receiving particularly the capsule and also the tablet forms of Tetracyclines. Most of the patients were reported to have taken medication immediately before going to bed (see DOSAGE AND ADMINISTRATION ).

Teeth:

permanent discoloration of teeth may be caused during tooth development. Enamel hypoplasia has also been reported (see WARNINGS ).

Skin:

maculopapular and erythematous rashes. Exfoliative dermatitis has been reported but is uncommon. Onycholysis and discoloration of the nails have been reported rarely. Photosensitivity is discussed in WARNINGS .

Renal toxicity:

rise in BUN has been reported and is apparently dose related.

Liver:

hepatotoxicity and liver failure have been observed in patients receiving large doses of Tetracycline and in Tetracycline-treated patients with renal impairment.

Hypersensitivity reactions:

urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, pericarditis, exacerbation of systemic lupus erythematosus, and serum sickness-like reactions, as fever, rash, and arthralgia.

Blood:

hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, neutropenia and eosinophilia have been reported.

Other:

bulging fontanels in infants and intracranial pressure in adults (see PRECAUTIONS, General ).

When given over prolonged periods, Tetracyclines have been reported to produce brown-black microscopic discoloration of thyroid glands. No abnormalities of thyroid function studies are known to occur.

To report SUSPECTED ADVERSE EVENTS, contact Actavis at 1-800-272-5525 or FDA at 1-800-FDA - 1088 or h ttp://www. fda. gov/ for voluntary reporting of adverse reactions.

Overdosage

In case of overdosage, discontinue medication, treat symptomatically and institute supportive measures. Tetracycline is not dialyzable.

Tetracycline Dosage and Administration

Adults

Usual daily dose, 1 gram as 500 mg twice daily or 250 mg four times a day. Higher doses such as 500 mg four times a day may be required for severe infections or for those infections which do not respond to the smaller doses

Children above eight years of age

Usual daily dose, 10 to 20 mg/lb (25 to 50 mg/kg) body weight divided in four equal doses.

Therapy should be continued for at least 24 to 48 hours after symptoms and fever have subsided.

For treatment of brucellosis, 500 mg Tetracycline four times a day for three weeks should be accompanied by streptomycin, 1 gram intramuscularly twice daily the first week and once daily the second week.

For the treatment of syphilis in patients allergic to penicillin, the following dosage of Tetracycline is recommended: early syphilis (less than one year’s duration), 500 mg four times a day for 15 days. Syphilis of more than one year’s duration (except neurosyphilis), 500 mg four times a day for 30 days.

For treatment of gonorrhea, the recommended dose is 500 mg by mouth four times a day for seven days.

In cases of moderate to severe acne which, in the judgement of the clinician, require long-term treatment, the recommended initial dosage is 1 gram daily in divided doses. When improvement is noted, dosage should be gradually reduced to maintenance levels ranging from 125 mg to 500 mg daily. In some patients it may be possible to maintain adequate remission of lesions with alternate day or intermittent therapy. Tetracycline therapy of acne should augment the other standard measures known to be of value. Duration of long-term treatment which can safely be recommended has not been established (see WARNINGS and Carcinogenesis, Mutagenesis , Impairment of Fertilit y ).

Concomitant therapy

Absorption of Tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and preparations containing iron, zinc, or sodium bicarbonate.

Food and some dairy products also interfere with absorption.

In the treatment of streptococcal infections, a therapeutic dose of Tetracycline should be administered for at least ten days.

In patients with renal impairment (see WARNINGS ) total dosage should be decreased by reduction of recommended individual doses and/or by extending time intervals between doses.

Uncomplicated urethral, endocervical or rectal infections in adults caused by Chlamydia trachomatis. 500 mg, by mouth, four times a day for at least seven days.

Administration of adequate amounts of fluid with the capsule formulation of Tetracycline is recommended to wash down the drug and reduce the risk of esophageal irritation and ulceration (see ADVERSE REACTIONS ).

How is Tetracycline Supplied

Tetracycline Hydrochloride Capsules, USP are available as: 250 mg: Orange/yellow capsules, imprinted with “ WPI ” on cap and “ 2234 ” on body.

Available in bottles of:

100 NDC 0591-2474-01 1000 NDC 0591-2474-10

500 mg: Black/yellow capsules, imprinted with “ WPI ” on cap and “ 2235 ” on body.

Available in bottles of:

100 NDC 0591-2475-01 1000 NDC 0591-2475-10

Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).

Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].

KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.

ANIMAL PHARMACOLOGY AND ANIMAL TOXICOLOGY

Hyperpigmentation of the thyroid has been produced by members of the Tetracycline class in the following species: in rats by oxyTetracycline, doxycycline, minocycline, Tetracycline PO4 and methacycline; in minipigs by doxycycline, minocycline, Tetracycline PO4 and methacycline; in dogs by doxycycline and minocycline; in monkeys by minocycline. Minocycline, Tetracycline PO4, methacycline, doxycycline, Tetracycline base, oxyTetracycline HCl and Tetracycline HCl were goitrogenic in rats fed a low iodine diet. This goitrogenic effect was accomplished by high radioactive iodine uptake. Administration of minocycline also produced a large goiter with high radioiodine uptake in rats fed a relatively high iodine diet. Treatment of various animal species with this class of drugs has also resulted in the induction of thyroid hyperplasia in the following: in rats and dogs (minocycline), in chickens (chlorTetracycline) and in rats and mice (oxyTetracycline). Adrenal gland hyperplasia has been observed in goats and rats treated with oxyTetracycline.

REFERENCES

1. Clinical and Laboratory Standards Institute (CLSI). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically; Approved Standard - Ninth Edition. CLSI document M07-A9, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2012.

2. Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Disk Diffusion Susceptibility Tests; Approved Standard – Eleventh Edition. CLSI document M02-A11, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2012.

3. Clinical and Laboratory Standards Institute (CLSI). Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria; Approved Guideline – Second Edition. CLSI document M45-A, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2010.

4. Clinical and Laboratory Standards Institute (CLSI). Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria; Approved Standard - Eight Edition. CLSI document M11-A8. Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, PA 19087 USA, 2012.

5. Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-third Informational Supplement. CLSI document M100-S23. CLSI document M100-S23, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2013.

Manufactured by: Watson Pharma Private Limited Verna, Salcette Goa 403 722 INDIA

Distributed by: Actavis Pharma, Inc. Parsippany, NJ 07054 USA

Revised: January 2016

PRINCIPAL DISPLAY PANEL

NDC 0591- 2474 -01 Tetracycline Hydrochloride Capsules, USP 250 mg 100 Capsules Rx Only

PRINCIPAL DISPLAY PANEL

NDC 0591- 2475 -01 Tetracycline Hydrochloride Capsules, USP 500 mg 100 Capsules Rx Only



Buy Online Tetracycline - Fda Prescribing Information, Side Effects And Uses, Tetraciclina

Isotretinoin Indications, Side Effects, Warnings, Isotretinoinum

Isotretinoin

Generic Name: isotretinoin (EYE-soe-TRET-i-noyn) Brand Name: Examples include Claravis and Sotret

Do not use isotretinoin if you are pregnant, may become pregnant, or if you are planning to become pregnant. Serious and sometimes fatal birth defects can occur if isotretinoin is taken during pregnancy. Any fetus exposed during pregnancy could be harmed. There is no accurate way to tell if an exposed fetus has been harmed. Increased risks of miscarriage and premature births have been reported. Isotretinoin can only be dispensed through a special program. You must watch a videotape on contraceptive methods and completely abstain from sexual intercourse or practice 2 forms of birth control beginning 1 month before, during, and for 1 month after use of isotretinoin. You must have 2 negative urine or blood pregnancy tests before you may begin taking isotretinoin. The second test must be done in a lab. You must have a negative result from a urine or blood pregnancy test done in a lab repeated each month before you receive your refill of isotretinoin. If you do not have regular menstrual cycles or you have unprotected sex at any time within 1 month before, during, or 1 month after use of isotretinoin, your doctor or other health care provider will give you special instructions regarding how to take your pregnancy tests. After discussing this medication with your health care provider, you must read, initial, and sign a consent form before taking isotretinoin. Do not sign the consent form if there is anything you do not understand. Additional negative pregnancy tests will be required every month during treatment.

Isotretinoin is used for:

Treating severe acne in patients who do not respond to other medicines. It may also be used for other conditions as determined by your doctor.

Isotretinoin is a retinoid. It works by reducing skin oil production, changing the characteristics of the skin oil, and preventing abnormal hardening of the skin.

Do NOT use isotretinoin if:

you are allergic to any ingredient in isotretinoin or to vitamin A

you are pregnant, may become pregnant, or if you are planning to become pregnant

you are breast-feeding

you do not understand the possible risks of isotretinoin or you are not able to follow all of the instructions in the Medication Guide

you are taking tetracycline antibiotics (eg, doxycycline) or vitamin A-type medicines (eg, etretinate, vitamin A)

Contact your doctor or health care provider right away if any of these apply to you.

Before using isotretinoin:

Some medical conditions may interact with isotretinoin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you are woman and unable to use 2 effective forms of birth control or avoid sexual intercourse

if you have a personal or family history of mental or mood problems (eg, depression), or suicidal thoughts or actions

if you have a personal or family history of asthma, diabetes, high blood cholesterol or triglyceride levels, heart disease, liver problems, bone loss (osteoporosis) or other bone problems (eg, weak bones), or an eating disorder (eg, anorexia)

if you have a history of hearing problems (eg, ringing in the ears, hearing loss), stomach or bowel problems (eg, severe stomach pain, rectal bleeding, persistent or severe diarrhea), pancreas problems (eg, pancreatitis), or irregular menstrual periods

if you are taking medicines that may decrease bone strength (eg, corticosteroids, such as prednisone; medicines for seizures, such as phenytoin)

Some MEDICINES MAY INTERACT with isotretinoin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Tetracyclines (eg, doxycycline) because the risk of increased pressure in the brain may be increased

St. John's wort because an increased risk of failure of hormonal contraceptives (eg, birth control pills) may occur

Vitamin A-type medicines (eg, etretinate, vitamin A) because they may increase the risk of isotretinoin's side effects

Progestin-only birth control (eg, "mini-pill") because their effectiveness may be decreased by isotretinoin

This may not be a complete list of all interactions that may occur. Ask your health care provider if isotretinoin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use isotretinoin:

Use isotretinoin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Isotretinoin comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get isotretinoin refilled.

Some brands of isotretinoin should be taken with food. Some brands may be taken with or without food. Ask your pharmacist if you should take your brand of isotretinoin with food.

Swallow the capsule with a full glass of water or other liquid. Do not break, crush, chew, or suck on the capsule before swallowing. This will help prevent the medication inside the capsule from irritating your throat.

For best results, take isotretinoin regularly. Taking isotretinoin at the same time each day will help you remember to take it.

Isotretinoin can only be dispensed through a special program. You must sign a consent form stating that you will follow your doctor's instructions before you can take isotretinoin. This will be necessary each time you refill your prescription.

You will get no more than a 30-day supply of isotretinoin at a time to ensure you check in with your doctor each month to discuss side effects.

If you miss a dose of isotretinoin, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use isotretinoin.

Important safety information:

Isotretinoin may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use isotretinoin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do NOT take more than the recommended dose or take isotretinoin for longer than prescribed without checking with your doctor. Doing so will not improve your condition faster and may increase your risk for side effects.

A sudden decrease in night vision may occur while you are taking isotretinoin. Use caution when driving at night and avoid driving at night if you experience decreased night vision.

If you wear contact lenses, you may have difficulty wearing them during and after therapy.

Do not donate blood while taking isotretinoin and for 1 month after you stop taking isotretinoin.

Do not drink alcohol while taking isotretinoin.

Worsening of acne may occur during the first part of therapy. This does not suggest failure or a need to stop the medicine.

To prevent cracking of lips, use a lip moisturizer or balm.

Do not have cosmetic procedures to smooth your skin, including waxing, dermabrasion, or laser procedures, while you are taking isotretinoin and for at least 6 months after you stop taking it. Isotretinoin can increase your chance of scarring from these procedures.

Isotretinoin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to isotretinoin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Some patients have become depressed or developed serious mental or mood problems while taking isotretinoin. Stop using isotretinoin and tell your health care provider right away if you have any new, worsened, or sudden symptoms, such as feeling sad or having crying spells; feeling anxious; becoming more irritable, angry, or aggressive than usual; losing pleasure or interest in social or sports activities; sleeping too much or too little; changes in weight or appetite; feeling like you have no energy; having trouble concentrating; or having thoughts about taking your life or hurting yourself (suicidal thoughts).

Isotretinoin may cause decreased bone strength in some patients. Patients who play vigorous impact sports may be at increased risk of bone problems (eg, fractures). Discuss any questions or concerns with your doctor.

Women who may become pregnant must use 2 effective forms of birth control at least 1 month before starting therapy, during therapy, and for 1 month after stopping the medicine. Your health care provider should conduct pregnancy tests on a monthly basis while you are taking isotretinoin.

Do not use progestin-only pills or "minipills" (pills that do not contain estrogen) for birth control because they may not work as well with isotretinoin. Ask your doctor or pharmacist if you are not sure what type of birth control pills you are using.

Women who use hormonal birth control should avoid the use of the herbal supplement St. John's wort because it may decrease the effectiveness of hormonal birth control.

Diabetes patients - Isotretinoin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including pregnancy tests, cholesterol and lipid levels, liver function, blood sugar levels, and white blood cell counts, may be performed while you use isotretinoin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Isotretinoin may affect normal growth in some CHILDREN. Caution is advised when using isotretinoin in children; they may be more sensitive to its effects. Consult your doctor for more details.

Isotretinoin should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: Do not use isotretinoin if you are pregnant. It has been shown to cause serious birth defects, miscarriage, early birth, or death of the fetus. Avoid becoming pregnant while you are taking it. If you have sex at any time without using 2 forms of effective birth control, become pregnant, think you may be pregnant, or miss your menstrual period, stop using isotretinoin and call your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while taking isotretinoin and for 1 month after stopping isotretinoin.

Possible side effects of isotretinoin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Chapped lips; dizziness; drowsiness; dry eyes, mouth, or skin; dry nose that may lead to nosebleeds; headache; temporary worsening of acne.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal hair growth; bleeding, redness, or swelling of the gums; bone pain; change in the amount of urine produced; chest pain; dark urine; difficult or painful swallowing; excessive thirst; fainting; fast heartbeat; hearing problems or ringing in the ears; joint or back pain; muscle pain or weakness; nausea; new or worsening heartburn; new or worsening mental, mood, or behavior changes (eg, bizarre, aggressive, or violent behavior; depression); red patches or bruises on the legs or arms; red, swollen, blistered, or peeling skin; seizures; severe headache; shortness of breath; stomach pain or tenderness; suicidal thoughts or actions; swollen glands; symptoms of increased pressure in the brain (eg, eye pressure, nausea, vomiting, vision changes); symptoms of infection (eg, fever, chills, sore throat); symptoms of a stroke (eg, confusion, one-sided weakness, slurred speech); symptoms of pancreatitis (eg, severe stomach or back pain, with or without nausea or vomiting); symptoms of stomach or bowel problems (eg, severe stomach or bowel pain, rectal bleeding, persistent or severe diarrhea); tightness in the lungs; unusual bruising or bleeding; unusual tiredness or weakness; vision changes; voice changes; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately. Symptoms may include dizziness; facial flushing; headache; loss of balance; stomach pain; vomiting.

Proper storage of isotretinoin:

Store isotretinoin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep isotretinoin out of the reach of children and away from pets.

General information:

If you have any questions about isotretinoin, please talk with your doctor, pharmacist, or other health care provider.

Isotretinoin is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take isotretinoin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about isotretinoin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to isotretinoin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using isotretinoin.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about isotretinoin



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Acquistare Generico Urosulol (Tamsulosin) Urosulol (Tamsulosin) Farmaci, Urosulol

Flomax is used for treating enlarged prostate (benign prostatic hyperplasia [BPH]). Flomax is an alpha-blocker. It works by relaxing muscles in the prostate and bladder, which helps to improve urine flow and reduce symptoms of BPH.

Use Flomax as directed by your doctor.

Take Flomax by mouth 30 minutes after eating the same meal each day.

Swallow Flomax whole. Do not break, crush, chew, or open capsules before swallowing.

If you miss a dose of Flomax, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss more than 2 dose of Flomax, contact your doctor for instructions.

Ask your health care provider any questions you may have about how to use Flomax.

Store Flomax at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Flomax out of the reach of children and away from pets.

Active Ingredient: Tamsulosin.

Do NOT use Flomax if:

you are allergic to any ingredient in Flomax

the patient is a woman or a child

you are taking another alpha-blocker (eg, prazosin).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Flomax. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines or other substances

if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any sulfonamide (sulfa) medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), sulfonylureas (eg, glyburide), probenecid, sulfamethoxazole, valdecoxib, or zonisamide.

if you have a history of liver or kidney problems, or high or low blood pressure, or prostate cancer

if you will be having eye surgery.

Some medicines may interact with Flomax. Tell your health care provider if you are taking any other medicines, especially any of the following:

Alpha-blockers (eg, prazosin) or phosphodiesterase inhibitors (eg, sildenafil) because symptoms of low blood pressure (eg, severe dizziness, lightheadedness, fainting) may occur

Azole antifungals (eg, ketoconazole), cimetidine, or serotonin specific reuptake inhibitors (eg, fluoxetine) because they may increase the risk of Flomax's side effects

Warfarin because the risk of side effects may be increased.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Flomax may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Flomax may cause drowsiness, dizziness, blurred vision, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Flomax with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Flomax may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Do not drive or perform other possibly unsafe tasks for 12 hours after your first dose of Flomax or after any dose increase.

Tell your doctor or dentist that you take Flomax before you receive any medical or dental care, emergency care, or surgery.

Flomax may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.

You will need to have regular check-ups with your doctor while you are using Flomax. Be sure to keep all doctor and lab appointments.

Flomax is for use by men only and should not be used by women.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; blurred vision; cough; decreased sexual ability; diarrhea; dizziness; drowsiness; lightheadedness; runny or stuffy nose; sinus inflammation; trouble sleeping; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fever, chills, or persistent sore throat; irregular heartbeat; prolonged, painful erection; severe of persistent dizziness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Voltaren 50 Mg Dispersible Tablets, Divoltar

VOLTAREN 50 MG DISPERSIBLE TABLETS

Transcript

PACKAGE LEAFLET: INFORMATION FOR THE USER VOLTAROL® 50MG DISPERSIBLE TABLETS / VOLTAREN® 50MG DISPERSIBLE TABLETS / DICLOFENAC 50MG DISPERSIBLE TABLETS (diclofenac sodium) This medicine will be referred to as Voltarol Tablets throughout the remainder of this leaflet. What you need to know about Voltarol Tablets Your doctor has decided that you need this medicine to help treat your condition. Please read this leaflet carefully before you start to take your medicine. It contains important information. Keep the leaflet in a safe place because you may want to read it again. If you have any other questions, or if there is something you don’t understand, please ask your doctor or pharmacist. This medicine has been prescribed for you. Never give it to someone else. It may not be the right medicine for them even if their symptoms seem to be the same as yours. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. In this leaflet: 1. What Voltarol Tablets are, and what they are used for 2. Things to consider before you start to take Voltarol Tablets 3. How to take Voltarol Tablets 4. Possible side effects 5. How to store Voltarol Tablets 6. Further information 1. What Voltarol Tablets are, and what they are used for Diclofenac sodium, the active ingredient in Voltarol Tablets, is one of a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs reduce pain and inflammation. Voltarol Tablets act quickly and so are used to treat short term painful conditions affecting the joints and muscles. They are especially useful for the treatment of sprains, strains and back pain. They should not be taken for more than three months. 2. Things to consider before you start to take Voltarol Tablets Some people MUST NOT take Voltarol Dispersible Tablets. Talk to your doctor if: ?? you think you may be allergic to diclofenac sodium, aspirin, ibuprofen or any other NSAID, or to any of the other ingredients of Voltarol Dispersible Tablets. (These are listed at the end of the leaflet.) Signs of a hypersensitivity reaction include swelling of the face and mouth (angioedema), breathing problems, runny nose, skin rash or any other allergic type reaction ?? you have now, or have ever had, a stomach (gastric) or duodenal (peptic) ulcer, or bleeding in the digestive tract (this can include blood in vomit, bleeding when emptying bowels, fresh blood in faeces or black, tarry faeces) ?? you have had stomach or bowel problems after you have taken other NSAIDs ?? you have severe heart, kidney or liver failure ?? if you have established heart disease and/or cerebrovascular disease e. g. if you have had a heart attack, stroke, mini-stroke (TIA) or blockages to blood vessels to the heart or brain or an operation to clear or bypass blockages ?? if you have or have had problems with your blood circulation (peripheral arterial disease) ?? you are more than six months pregnant. You should also ask yourself these questions before taking Voltarol Dispersible Tablets: ?? Do you suffer from any stomach or bowel disorders including ulcerative colitis or Crohn's disease? ?? Do you have kidney or liver problems, or are you elderly? ?? Do you have a condition called porphyria? ?? Do you suffer from any blood or bleeding disorder? If you do, your doctor may ask you to go for regular check-ups while you are taking these tablets. ?? Have you ever had asthma? ?? Are you breast-feeding? ?? Do you have angina, blood clots, high blood pressure, raised cholesterol or raised triglycerides ?? Do you have heart problems, or have you had a stroke, or do you think you might be at risk of these conditions (for example, if you have high blood pressure, diabetes, or high cholesterol or are you a smoker)? ?? Do you have diabetes ?? Do you smoke ?? Do you have Lupus (SLE) or any similar condition?

If the answer to any of these questions is YES, discuss your treatment with your doctor or pharmacist because Voltarol Dispersible Tablets might not be the right medicine for you.

The usual doses are: Adults One tablet two or three times a day.

Are you taking other medicines? Some medicines can interfere with your treatment. Tell your doctor or pharmacist if you are taking any of the following: ?? Medicines to treat diabetes ?? Anticoagulants (blood thinning tablets like warfarin) ?? Diuretics (water tablets) ?? Lithium (used to treat some mental problems) ?? Methotrexate (for some inflammatory diseases and some cancers) ?? Ciclosporin and tacrolimus (used to treat some inflammatory diseases and after transplants) ?? Trimethoprim (a medicine used to prevent or treat urinary tract infections) ?? Quinolone antibiotics (for infections) ?? Any other NSAID or COX-2 (cyclo-oxgenase-2) inhibitor, for example aspirin or ibuprofen ?? Mifepristone (a medicine used to terminate pregnancy) ?? Cardiac glycosides (for example digoxin), used to treat heart problems ?? Medicines known as SSRIs used to treat depression ?? Oral steroids (an anti-inflammatory drug) ?? Medicines used to treat heart conditions or high blood pressure, for example beta - blockers or ACE inhibitors. ?? Voriconazole (a medicine used to treat fungal infections). ?? Phenytoin (a medicine used to treat seizures) ?? Colestipol/cholestyramine (used to lower cholesterol)

Elderly Your doctor may advise you to take a dose that is lower than the usual adult dose if you are elderly. Your doctor may also want to check closely that the Voltarol Tablets are not affecting your stomach.

Always tell your doctor or pharmacist about all the medicines you are taking. This means medicines you have bought yourself as well as medicines on prescription from your doctor. Pregnancy ?? Are you pregnant or planning to become pregnant? Although not common, abnormalities have been reported in babies whose mothers have taken NSAIDs during pregnancy. You should not take Voltarol Dispersible Tablets during the last 3 months of pregnancy as it may affect the baby’s circulation. ?? Are you trying for a baby? Taking Voltarol Dispersible Tablets may make it more difficult to conceive. You should talk to your doctor if you are planning to become pregnant, or if you have problems getting pregnant. Will there be any problems with driving or using machinery? Very occasionally people have reported that Voltarol Dispersible Tablets have made them feel dizzy, tired or sleepy. Problems with eyesight have also been reported. If you are affected in this way, you should not drive or operate machinery. Other special warnings ?? You should take the lowest dose of Voltarol Dispersible Tablets for the shortest possible time, particularly if you are underweight or elderly. ?? There is a small increased risk of heart attack or stroke when you are taking any medicine like Voltarol. The risk is higher if you are taking high doses for a long time. Always follow the doctor’s instructions on how much to take and how long to take it for. ?? Whilst you are taking these medicines your doctor may want to give you a check-up from time to time. ?? If you have a history of stomach problems when you are taking NSAIDs, particularly if you are elderly, you must tell your doctor straight away if you notice any unusual symptoms. ?? Because it is an anti-inflammatory medicine, Voltarol Dispersible Tablets may reduce the symptoms of infection, for example headache, and high temperature. If you feel unwell and need to see a doctor, remember to tell him or her that you are taking Voltarol Dispersible Tablets. ?? Voltarol Dispersible Tablets are not suitable for children. The tablets contain erythrosine and may be unsuitable for some people. 3. How to take Voltarol Tablets The doctor will tell you how many Voltarol Tablets to take and when to take them. Always follow his/her instructions carefully. The dose will be on the pharmacist’s label. Check the label carefully. If you are not sure, ask your doctor or pharmacist. Keep taking your tablets for as long as you have been told, unless you have any problems. In that case, check with your doctor. Take the tablets before or with food. Drop the tablets into a glass of water, and stir. Drink the liquid at once. To make sure you get all of the medicine, rinse the glass round with a small amount of water and drink this as well.

These tablets are not suitable for children. The doctor may also prescribe another drug to protect the stomach to be taken at the same time, particularly if you have had stomach problems before, or if you are elderly, or taking certain other drugs as well. What if you forget to take a dose? If you forget to take a dose, take one as soon as you remember. If it is nearly time for your next dose, though, just take the next dose and forget about the one you missed. Do not double up on the next dose to make up for the one missed. Do not take more than 150 mg (three tablets) in 24 hours. What if you take too many tablets? If you, or anyone else, accidentally takes too much, tell your doctor or your nearest hospital casualty department. Take your medicine pack with you so that people can see what you have taken.

Effects on the stomach and digestive system: Constipation, inflammation of the tongue, mouth ulcers, inflammation of the inside of the mouth or lips, taste changes, lower gut disorders (including inflammation of the colon, or worsening of ulcerative colitis or Crohn’s disease). Effects on the heart, chest or blood: Palpitations (fast or irregular heart beat), chest pain, hypertension (high blood pressure), inflammation of blood vessels (vasculitis), inflammation of the lung (pneumonitis), heart disorders, including congestive heart failure or heart attack, blood disorders (including anaemia), stroke. Effects on the liver or kidneys: Kidney or severe liver disorders including liver failure, presence of blood or protein in the urine. Effects on skin or hair: Serious skin rashes including Stevens-Johnson syndrome and Lyell’s syndrome and other skin rashes which may be made worse by exposure to sunlight. Hair loss. Other side effects that have also been reported include: Inflammation of the pancreas, impotence. Facial swelling, inflammation of the lining of the brain (meningitis), stroke, throat disorders, confusion, hallucinations, malaise (general feeling of discomfort), inflammation of the nerves in the eye.

4. Possible side effects Voltarol Dispersible Tablets are suitable for most people, but, like all medicines, they can sometimes cause side effects. Side effects may be minimised by using the lowest effective dose for the shortest duration necessary. Some side effects can be serious Stop taking Voltarol Dispersible Tablets and tell your doctor straight away if you notice: ?? Stomach pain, indigestion, heartburn, wind, nausea (feeling sick) or vomiting (being sick) ?? Any sign of bleeding in the stomach or intestine, for example, when emptying your bowels, blood in vomit or black, tarry faeces ?? Allergic reactions which can include skin rash, itching, bruising, painful red areas, peeling or blistering ?? Wheezing or shortness of breath (bronchospasm) ?? Swollen face, lips, hands or fingers ?? Yellowing of your skin or the whites of your eyes ?? Persistent sore throat or high temperature ?? An unexpected change in the amount of urine produced and/or its appearance. If you notice that you are bruising more easily than usual or have frequent sore throats or Infections, tell your doctor. The side effects listed below have also been reported. Common side effects (These may affect between 1 and 10 in every 100 patients): ?? Stomach pain, heartburn, nausea, vomiting, diarrhoea, indigestion, wind, loss of appetite ?? Headache, dizziness, vertigo ?? Skin rash or spots ?? Raised levels of liver enzymes in the blood Rare side effects (These may affect between 1 in every 1000 to 1 in every 10,000 patients): ?? Stomach ulcers or bleeding (there have been very rare reported cases resulting in death, particularly in the elderly) ?? Gastritis (inflammation, irritation or swelling of the stomach lining) ?? Vomiting blood ?? Diarrhoea with blood in it or bleeding from the back passage ?? Black, tarry faeces or stools ?? Drowsiness, tiredness ?? Hypotension (low blood pressure, symptoms of which may include faintness, giddiness or light headedness) ?? Skin rash and itching ?? Fluid retention, symptoms of which include swollen ankles ?? Liver function disorders, including hepatitis and jaundice Very Rare side effects (These may affect less than 1 in every 10,000 patients): Effects on the nervous system: Tingling or numbness in the fingers, tremor, visual disturbances such as blurred or double vision, hearing loss or impairment, tinnitus (ringing in the ears), sleeplessness, nightmares, mood changes, depression, anxiety, mental disorders, disorientation and loss of memory, fits, headaches together with a dislike of bright lights, fever and a stiff neck, disturbances in sensation.

Do not be alarmed by this list - most people take Voltarol Dispersible Tablets without any problems. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard. By reporting side effects, you can help provide more information on the safety of this medicine. 5. How to store Voltarol Tablets The expiry date for these tablets is given on the carton. Do not take the tablets after this date. Do not store above 25°C. Store in the original package. KEEP OUT OF THE SIGHT AND REACH OF CHILDREN. If your doctor tells you to stop taking the tablets, please take any unused tablets back to your pharmacist to be destroyed. Do not throw them away with your normal household water or waste. This will help to protect the environment. 6. Further information Voltarol Tablets contain diclofenac. Each tablet contains 46.5mg of diclofenac equivalent to 50mg of diclofenac sodium. The tablets also contain the following inactive ingredients: croscarmellose sodium, microcrystalline cellulose, sodium starch glycollate, talc, colloidal silicon dioxide and hydrogenated castor oil. This product does not contain any flavouring agents but this does not affect the efficacy or safety of the product. Warning: This product contains hydrogenated castor oil. It may cause stomach upset and diarrhoea. Voltarol Tablets are white, triangular shaped tablets, with the letter V on the front and the letters CG on the back. Voltarol Tablets are available in blister packs of 20 tablets. Manufacturer This product is manufactured by; Novartis Pharma AG, Stein, Switzerland. It is procured from within the EU. Product Licence holder: G Pharma Ltd, Dakota Ave, Salford, M50 2PU PL 16369/0354 This leaflet was last revised:

‘Voltarol’ and ‘Voltaren’ are registered trademarks of Novartis AG.

PACKAGE LEAFLET: INFORMATION FOR THE USER VOLTAROL® 50MG DISPERSIBLE TABLETS / VOLTAREN® 50MG DISPERSIBLE TABLETS / DICLOFENAC 50MG DISPERSIBLE TABLETS (diclofenac sodium) This medicine will be referred to as Voltarol Tablets throughout the remainder of this leaflet. What you need to know about Voltarol Tablets Your doctor has decided that you need this medicine to help treat your condition. Please read this leaflet carefully before you start to take your medicine. It contains important information. Keep the leaflet in a safe place because you may want to read it again. If you have any other questions, or if there is something you don’t understand, please ask your doctor or pharmacist. This medicine has been prescribed for you. Never give it to someone else. It may not be the right medicine for them even if their symptoms seem to be the same as yours. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. In this leaflet: 1. What Voltarol Tablets are, and what they are used for 2. Things to consider before you start to take Voltarol Tablets 3. How to take Voltarol Tablets 4. Possible side effects 5. How to store Voltarol Tablets 6. Further information 1. What Voltarol Tablets are, and what they are used for Diclofenac sodium, the active ingredient in Voltarol Tablets, is one of a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs reduce pain and inflammation. Voltarol Tablets act quickly and so are used to treat short term painful conditions affecting the joints and muscles. They are especially useful for the treatment of sprains, strains and back pain. They should not be taken for more than three months. 2. Things to consider before you start to take Voltarol Tablets Some people MUST NOT take Voltarol Dispersible Tablets. Talk to your doctor if: ?? you think you may be allergic to diclofenac sodium, aspirin, ibuprofen or any other NSAID, or to any of the other ingredients of Voltarol Dispersible Tablets. (These are listed at the end of the leaflet.) Signs of a hypersensitivity reaction include swelling of the face and mouth (angioedema), breathing problems, runny nose, skin rash or any other allergic type reaction ?? you have now, or have ever had, a stomach (gastric) or duodenal (peptic) ulcer, or bleeding in the digestive tract (this can include blood in vomit, bleeding when emptying bowels, fresh blood in faeces or black, tarry faeces) ?? you have had stomach or bowel problems after you have taken other NSAIDs ?? you have severe heart, kidney or liver failure ?? if you have established heart disease and/or cerebrovascular disease e. g. if you have had a heart attack, stroke, mini-stroke (TIA) or blockages to blood vessels to the heart or brain or an operation to clear or bypass blockages ?? if you have or have had problems with your blood circulation (peripheral arterial disease) ?? you are more than six months pregnant. You should also ask yourself these questions before taking Voltarol Dispersible Tablets: ?? Do you suffer from any stomach or bowel disorders including ulcerative colitis or Crohn's disease? ?? Do you have kidney or liver problems, or are you elderly? ?? Do you have a condition called porphyria? ?? Do you suffer from any blood or bleeding disorder? If you do, your doctor may ask you to go for regular check-ups while you are taking these tablets. ?? Have you ever had asthma? ?? Are you breast-feeding? ?? Do you have angina, blood clots, high blood pressure, raised cholesterol or raised triglycerides ?? Do you have heart problems, or have you had a stroke, or do you think you might be at risk of these conditions (for example, if you have high blood pressure, diabetes, or high cholesterol or are you a smoker)? ?? Do you have diabetes ?? Do you smoke ?? Do you have Lupus (SLE) or any similar condition?

If the answer to any of these questions is YES, discuss your treatment with your doctor or pharmacist because Voltarol Dispersible Tablets might not be the right medicine for you.

The usual doses are: Adults One tablet two or three times a day.

Are you taking other medicines? Some medicines can interfere with your treatment. Tell your doctor or pharmacist if you are taking any of the following: ?? Medicines to treat diabetes ?? Anticoagulants (blood thinning tablets like warfarin) ?? Diuretics (water tablets) ?? Lithium (used to treat some mental problems) ?? Methotrexate (for some inflammatory diseases and some cancers) ?? Ciclosporin and tacrolimus (used to treat some inflammatory diseases and after transplants) ?? Trimethoprim (a medicine used to prevent or treat urinary tract infections) ?? Quinolone antibiotics (for infections) ?? Any other NSAID or COX-2 (cyclo-oxgenase-2) inhibitor, for example aspirin or ibuprofen ?? Mifepristone (a medicine used to terminate pregnancy) ?? Cardiac glycosides (for example digoxin), used to treat heart problems ?? Medicines known as SSRIs used to treat depression ?? Oral steroids (an anti-inflammatory drug) ?? Medicines used to treat heart conditions or high blood pressure, for example beta - blockers or ACE inhibitors. ?? Voriconazole (a medicine used to treat fungal infections). ?? Phenytoin (a medicine used to treat seizures) ?? Colestipol/cholestyramine (used to lower cholesterol)

Elderly Your doctor may advise you to take a dose that is lower than the usual adult dose if you are elderly. Your doctor may also want to check closely that the Voltarol Tablets are not affecting your stomach.

Always tell your doctor or pharmacist about all the medicines you are taking. This means medicines you have bought yourself as well as medicines on prescription from your doctor. Pregnancy ?? Are you pregnant or planning to become pregnant? Although not common, abnormalities have been reported in babies whose mothers have taken NSAIDs during pregnancy. You should not take Voltarol Dispersible Tablets during the last 3 months of pregnancy as it may affect the baby’s circulation. ?? Are you trying for a baby? Taking Voltarol Dispersible Tablets may make it more difficult to conceive. You should talk to your doctor if you are planning to become pregnant, or if you have problems getting pregnant. Will there be any problems with driving or using machinery? Very occasionally people have reported that Voltarol Dispersible Tablets have made them feel dizzy, tired or sleepy. Problems with eyesight have also been reported. If you are affected in this way, you should not drive or operate machinery. Other special warnings ?? You should take the lowest dose of Voltarol Dispersible Tablets for the shortest possible time, particularly if you are underweight or elderly. ?? There is a small increased risk of heart attack or stroke when you are taking any medicine like Voltarol. The risk is higher if you are taking high doses for a long time. Always follow the doctor’s instructions on how much to take and how long to take it for. ?? Whilst you are taking these medicines your doctor may want to give you a check-up from time to time. ?? If you have a history of stomach problems when you are taking NSAIDs, particularly if you are elderly, you must tell your doctor straight away if you notice any unusual symptoms. ?? Because it is an anti-inflammatory medicine, Voltarol Dispersible Tablets may reduce the symptoms of infection, for example headache, and high temperature. If you feel unwell and need to see a doctor, remember to tell him or her that you are taking Voltarol Dispersible Tablets. ?? Voltarol Dispersible Tablets are not suitable for children. The tablets contain erythrosine and may be unsuitable for some people. 3. How to take Voltarol Tablets The doctor will tell you how many Voltarol Tablets to take and when to take them. Always follow his/her instructions carefully. The dose will be on the pharmacist’s label. Check the label carefully. If you are not sure, ask your doctor or pharmacist. Keep taking your tablets for as long as you have been told, unless you have any problems. In that case, check with your doctor. Take the tablets before or with food. Drop the tablets into a glass of water, and stir. Drink the liquid at once. To make sure you get all of the medicine, rinse the glass round with a small amount of water and drink this as well.

These tablets are not suitable for children. The doctor may also prescribe another drug to protect the stomach to be taken at the same time, particularly if you have had stomach problems before, or if you are elderly, or taking certain other drugs as well. What if you forget to take a dose? If you forget to take a dose, take one as soon as you remember. If it is nearly time for your next dose, though, just take the next dose and forget about the one you missed. Do not double up on the next dose to make up for the one missed. Do not take more than 150 mg (three tablets) in 24 hours. What if you take too many tablets? If you, or anyone else, accidentally takes too much, tell your doctor or your nearest hospital casualty department. Take your medicine pack with you so that people can see what you have taken.

Effects on the stomach and digestive system: Constipation, inflammation of the tongue, mouth ulcers, inflammation of the inside of the mouth or lips, taste changes, lower gut disorders (including inflammation of the colon, or worsening of ulcerative colitis or Crohn’s disease). Effects on the heart, chest or blood: Palpitations (fast or irregular heart beat), chest pain, hypertension (high blood pressure), inflammation of blood vessels (vasculitis), inflammation of the lung (pneumonitis), heart disorders, including congestive heart failure or heart attack, blood disorders (including anaemia), stroke. Effects on the liver or kidneys: Kidney or severe liver disorders including liver failure, presence of blood or protein in the urine. Effects on skin or hair: Serious skin rashes including Stevens-Johnson syndrome and Lyell’s syndrome and other skin rashes which may be made worse by exposure to sunlight. Hair loss. Other side effects that have also been reported include: Inflammation of the pancreas, impotence. Facial swelling, inflammation of the lining of the brain (meningitis), stroke, throat disorders, confusion, hallucinations, malaise (general feeling of discomfort), inflammation of the nerves in the eye.

4. Possible side effects Voltarol Dispersible Tablets are suitable for most people, but, like all medicines, they can sometimes cause side effects. Side effects may be minimised by using the lowest effective dose for the shortest duration necessary. Some side effects can be serious Stop taking Voltarol Dispersible Tablets and tell your doctor straight away if you notice: ?? Stomach pain, indigestion, heartburn, wind, nausea (feeling sick) or vomiting (being sick) ?? Any sign of bleeding in the stomach or intestine, for example, when emptying your bowels, blood in vomit or black, tarry faeces ?? Allergic reactions which can include skin rash, itching, bruising, painful red areas, peeling or blistering ?? Wheezing or shortness of breath (bronchospasm) ?? Swollen face, lips, hands or fingers ?? Yellowing of your skin or the whites of your eyes ?? Persistent sore throat or high temperature ?? An unexpected change in the amount of urine produced and/or its appearance. If you notice that you are bruising more easily than usual or have frequent sore throats or Infections, tell your doctor. The side effects listed below have also been reported. Common side effects (These may affect between 1 and 10 in every 100 patients): ?? Stomach pain, heartburn, nausea, vomiting, diarrhoea, indigestion, wind, loss of appetite ?? Headache, dizziness, vertigo ?? Skin rash or spots ?? Raised levels of liver enzymes in the blood Rare side effects (These may affect between 1 in every 1000 to 1 in every 10,000 patients): ?? Stomach ulcers or bleeding (there have been very rare reported cases resulting in death, particularly in the elderly) ?? Gastritis (inflammation, irritation or swelling of the stomach lining) ?? Vomiting blood ?? Diarrhoea with blood in it or bleeding from the back passage ?? Black, tarry faeces or stools ?? Drowsiness, tiredness ?? Hypotension (low blood pressure, symptoms of which may include faintness, giddiness or light headedness) ?? Skin rash and itching ?? Fluid retention, symptoms of which include swollen ankles ?? Liver function disorders, including hepatitis and jaundice Very Rare side effects (These may affect less than 1 in every 10,000 patients): Effects on the nervous system: Tingling or numbness in the fingers, tremor, visual disturbances such as blurred or double vision, hearing loss or impairment, tinnitus (ringing in the ears), sleeplessness, nightmares, mood changes, depression, anxiety, mental disorders, disorientation and loss of memory, fits, headaches together with a dislike of bright lights, fever and a stiff neck, disturbances in sensation.

Do not be alarmed by this list - most people take Voltarol Dispersible Tablets without any problems. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard. By reporting side effects, you can help provide more information on the safety of this medicine. 5. How to store Voltarol Tablets The expiry date for these tablets is given on the carton. Do not take the tablets after this date. Do not store above 25°C. Store in the original package. KEEP OUT OF THE SIGHT AND REACH OF CHILDREN. If your doctor tells you to stop taking the tablets, please take any unused tablets back to your pharmacist to be destroyed. Do not throw them away with your normal household water or waste. This will help to protect the environment. 6. Further information Voltarol Tablets contain diclofenac. Each tablet contains 46.5mg of diclofenac equivalent to 50mg of diclofenac sodium. The tablets also contain the following inactive ingredients: croscarmellose sodium, microcrystalline cellulose, sodium starch glycollate, talc, colloidal silicon dioxide and hydrogenated castor oil. This product does not contain any flavouring agents but this does not affect the efficacy or safety of the product. Warning: This product contains hydrogenated castor oil. It may cause stomach upset and diarrhoea. Voltarol Tablets are white, triangular shaped tablets, with the letter V on the front and the letters CG on the back. Voltarol Tablets are available in blister packs of 20 tablets. Manufacturer This product is manufactured by; Novartis Pharma AG, Stein, Switzerland. It is procured from within the EU. Product Licence holder: G Pharma Ltd, Dakota Ave, Salford, M50 2PU PL 16369/0354 This leaflet was last revised:

‘Voltarol’ and ‘Voltaren’ are registered trademarks of Novartis AG.

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



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Anacin - Pain Relief, Cupanol

Anacin is a pain reliever intended for the temporary relief of minor aches and pains. Anacin is a combination salicylate and stimulant. It works by blocking several different chemical processes within the body that cause pain, inflammation, and fever. It also reduces the tendency for blood to clot.

Availability: In Stock (17 packs)

Anacin is used for treating pain including, headache, muscle aches, sprains, tooth extraction and toothache, menstrual cramps, arthritis and rheumatism, and pain and fever of the common cold. It may also be used for other conditions as determined by your doctor.

Use Anacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Anacin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Taking it with food may not decrease the risk of stomach or bowel problems (eg, bleeding, ulcers) that may occur while taking Anacin.

Take Anacin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Anacin.

Use Anacin exactly as directed on the package, unless instructed differently by your doctor. If you are taking Anacin without a prescription, follow any warnings and precautions on the label.

If you miss a dose of Anacin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Anacin.

Store Anacin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Anacin out of the reach of children and away from pets.

Anacin may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Anacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate). This includes any medicines that contain caffeine.

Anacin has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Talk to your doctor before you take Anacin or other pain relievers/fever reducers if you drink more than 3 drinks with alcohol per day. Serious stomach ulcers or bleeding can occur with the use of Anacin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Anacin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Taking more than the recommended dose or taking Anacin regularly may be habit-forming.

Anacin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

Aspirin has been linked to a serious illness called Reye syndrome. Do not give Anacin to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.

Diabetes patients - Anacin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If Anacin has a strong vinegar-like smell upon opening, do not use. It means the medicine is breaking down. Throw the bottle away safely and out of the reach of children; contact your pharmacist and replace.

Tell your doctor or dentist that you take Anacin before you receive any medical or dental care, emergency care, or surgery.

Do not take Anacin for at least 7 days after any surgery unless directed by your health care provider.

Do not take Anacin for more than 10 days for pain or for more than 3 days for fever unless directed to do so by your health care provider.

Different brands of Anacin may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.

Do NOT use Anacin if:

you are allergic to any ingredient in Anacin

you are a child or teenager with influenza (flu) or chickenpox

you have bleeding problems such as hemophilia, von Willebrand disease, or low blood platelets, or you have active severe bleeding

you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness) to aspirin, tartrazine, or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)

you are taking anticoagulants (eg, heparin, warfarin) or methotrexate

Before using Anacin:

Some medical conditions may interact with Anacin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have alcoholism or if you consume 3 or more alcohol-containing drinks every day

if you have asthma, bleeding or clotting problems, growths in the nose (nasal polyps), kidney or liver problems, stomach or intestinal problems (eg, ulcer, inflammation), heart problems, heartburn, upset stomach, stomach pain, hives, influenza (flu) or chickenpox, or vitamin K deficiency

if you have anxiety, trouble sleeping, or heart problems

if you are a child with a stroke, a weakened blood vessel (cerebral aneurysm) or bleeding in the brain, rheumatic disease (eg, rheumatoid arthritis), or Kawasaki syndrome (a rare inflammation causing heart problems in children)

Some MEDICINES MAY INTERACT with Anacin. Tell your health care provider if you are taking any other medicines.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Anacin while you are pregnant. Anacin is not recommended during the last 3 months (third trimester) of pregnancy because it may cause harm to the fetus. Anacin is found in breast milk. If you are or will be breast-feeding while you use Anacin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects. Anacin's side effects may include dizziness, heartburn, irritability, nausea, nervousness, rashes, hives, bloody stools, drowsiness, hearing loss, ringing in the ears, and trouble sleeping.

Check with your doctor if any of the listed above most COMMON side effects persist or become bothersome.

Seek medical attention right away if any of these SEVERE side effects occur: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; confusion; diarrhea; drowsiness; hearing loss; ringing in the ears; severe or persistent dizziness; severe or persistent stomach pain or heartburn; shakiness; trouble sleeping; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.



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Fenofibrato Medlineplus Medicinas, Procetoken

Fenofibrato

?Para cuales condiciones o enfermedades se prescribe este medicamento?

El fenofibrato se usa junto con una dieta baja en grasas, ejercicio, y, a veces, con otros medicamentos para reducir las cantidades de sustancias grasas, como colesterol y trigliceridos, en la sangre y para aumentar la cantidad de HDL (lipoproteinas de alta densidad; un tipo de sustancia grasa que disminuye el riesgo de enfermedad del corazon) en la sangre. La acumulacion de colesterol y grasas en las paredes de las arterias (un proceso conocido como aterosclerosis) disminuye el flujo de sangre y, por lo tanto, la oxigenacion del corazon, del cerebro y de otras partes del cuerpo. Esto aumenta el riesgo de enfermedad del corazon, angina de pecho (dolor en el pecho), accidente cerebrovascular y ataque cardiaco. Si bien el fenofibrato reduce los niveles de sustancias grasas en la sangre, no se ha demostrado que reduzca el riesgo de padecer ataques cardiacos o derrames cerebrales. El fenofibrato pertenece a una clase de medicamentos llamados agentes antilipemicos. Actua acelerando los procesos naturales que eliminan el colesterol del cuerpo.

?Como se debe usar este medicamento?

La presentacion del fenofibrato es en capsulas, en capsulas de liberacion retardada (accion prolongada) y en tabletas para administrarse por via oral. Suele tomarse una vez al dia. Algunos productos de fenofibrato (Fenoglide, Lipofen y Lofibra) deben tomarse con las comidas. Otras marcas (Antara, Fibricor, Tricor, Triglide y Trilipix) pueden tomarse con o sin alimentos. Si no sabe si debe tomar su medicamento con alimentos, consulte a su medico o a su farmaceutico. Siga atentamente las instrucciones del medicamento recetado, y pidales a su medico o a su farmaceutico que le expliquen cualquier cosa que no entienda. Tome el fenofibrato segun lo indicado. No aumente ni disminuya la dosis, ni la tome con mas frecuencia que la indicada por su medico.

Es probable que su medico le recete al principio una dosis promedio de fenofibrato, y podra aumentar o disminuir su dosis en funcion de los resultados de las pruebas de laboratorio que le realizaran para medirle la cantidad de sustancias grasas en la sangre. Es posible que su medico le indique que deje de tomar fenofibrato si los resultados de sus pruebas no muestran una mejora despues de 2 meses.

Si esta tomando tabletas de Trilipix, trague las tabletas enteras; no las parta, ni mastique ni triture.

Si esta tomando tabletas de Triglide, no use ninguna tableta que este astillada o rota.

El fenofibrato lo ayudara a disminuir la cantidad de sustancias grasas en la sangre solo mientras siga tomandolo. Siga tomando el fenofibrato aunque se sienta bien. No deje de tomar el fenofibrato sin consultar a su medico.

?Que otro uso se le da a este medicamento?

Este medicamento puede recetarse para otros usos. Pidales mas informacion a su medico o a su farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes de tomar fenofibrato:

Informe a su medico y a su farmaceutico si es alergico a cualquier producto de fenofibrato, a algun otro medicamento o a alguno de los ingredientes del producto de fenofibrato que esta tomando. Pidale a su farmaceutico una lista de los ingredientes.

Informe a su medico y a su farmaceutico que medicamentos con y sin receta, vitaminas, suplementos nutricionales o productos herbarios esta tomando o planea tomar. No olvide mencionar ninguno de los siguientes: anticoagulantes ("diluyentes de la sangre"), como warfarina (Coumadin); colchicina (Colcrys, en Col-Probenecid); diureticos ("pastillas contra la retencion de agua"); bloqueadores beta, como atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard) y propranolol (Inderal); inhibidores de la reductasa de la HMG-CoA (medicamentos reductores del colesterol), como atorvastatina (Lipitor), lovastatina (Mevacor), pravastatina (Pravachol), rosuvastatina (Crestor) y simvastatina (Zocor); terapia de reemplazo hormonal; anticonceptivos hormonales (pildoras, parches, implantes, anillos e inyecciones anticonceptivos) e inmunosupresores, como ciclosporina (Sandimmune, Neoral) y tacrolimus (Prograf). Es posible que su medico deba cambiar las dosis de sus medicamentos o vigilarlo de cerca por si presentara efectos secundarios.

Si esta tomando una resina de acido biliar, como colestiramina (Questran), colesevelam (WelChol) o colestipol (Colestid), tomela 1 hora despues o de 4 a 6 horas antes de tomar fenofibrato.

Informe a su medico si tiene o alguna vez ha tenido alguna enfermedad del rinon, del higado o de la vesicula biliar. Es probable que su medico le diga que no tome fenofibrato.

Informe a su medico si si bebe o ha bebido grandes cantidades de alcohol y si tiene o alguna vez ha tenido diabetes o hipotiroidismo (poca actividad de la glandula tiroides).

Informe a su medico si esta embarazada o planea quedar embarazada. Si queda embarazada mientras toma fenofibrato, llame a su medico.

Informe a su medico si esta dando el pecho. No debe dar el pecho mientras este tomando fenofibrato.

?Que dieta especial debo seguir mientras tomo este medicamento?

Coma una dieta baja en grasa y baja en colesterol. Asegurese de seguir todas las recomendaciones de ejercicios y dieta que le haga su medico o nutricionista. Tambien puede visitar el sitio web del Programa nacional de educacion sobre el colesterol (National Cholesterol Education Program, NCEP) para obtener mas informacion nutricional en http://www. nhlbi. nih. gov/health/public/heart/chol/chol_tlc. pdf.

?Que tengo que hacer si me olvido de tomar una dosis?

Si olvida tomar una dosis, tomela en cuanto se acuerde. No obstante, si ya casi es hora de la dosis siguiente, deje pasar la dosis que olvido y continue con su horario de medicacion normal. No tome una dosis doble para compensar la que olvido.

?Cuales son los efectos secundarios que podria provocar este medicamento?

El fenofibrato puede provocar efectos secundarios. Informe a su medico si alguno de estos sintomas es intenso o no desaparece:

estrenimiento

diarrea

acidez estomacal

dolor en la espalda, en los brazos o en las piernas

dolor de cabeza

Algunos efectos secundarios pueden ser graves. Si presenta alguno de los siguientes sintomas, llame a su medico de inmediato:

debilidad

dolor o sensibilidad en los musculos

dolor articular

fiebre

ampollas o descamacion de la piel

sarpullido

urticaria

dolor en la parte superior de la espalda, entre los omoplatos o debajo del hombro derecho

dolor de estomago, especialmente en la parte superior derecha del estomago

nauseas

vomitos

enrojecimiento, inflamacion, dolor, sensibilidad o calor en una pierna

falta de aire

dolor al respirar

tos con sangre

El fenofibrato puede provocar otros efectos secundarios. Llame a su medico si tiene algun problema inusual mientras toma fenofibrato.

Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgacion de efectos adversos 'MedWatch' de la Administracion de Alimentos y Medicamentos (FDA, por su sigla en ingles) en la pagina de Internet (http://www. fda. gov/Safety/MedWatch ) o por telefono al 1-800-332-1088.

?Como debo almacenar o desechar este medicamento?

Mantenga este medicamento en su envase original, bien cerrado y fuera del alcance de los ninos. Almacenelo a temperatura ambiente y en un lugar alejado del exceso de calor y humedad (nunca en el cuarto de bano).

Los medicamentos que ya no son necesarios se deben desechar de una manera apropiada para asegurarse de que las mascotas, los ninos y otras personas no puedan consumirlos. Sin embargo, no debe desechar estos medicamentos por el inodoro. En su lugar, la mejor manera de deshacerse de sus medicamentos es a traves de un programa de devolucion de medicamentos. Hable con su farmaceutico o pongase en contacto con su departamento de basura/reciclaje local para conocer acerca de los programas de devolucion de medicamentos de su comunidad. Consulte el sitio web de la Administracion de Medicamentos y Alimentos (FDA), (http://goo. gl/c4Rm4p ) para obtener mas informacion de como desechar de forma segura los medicamentos, si no tiene acceso al programa de devolucion de medicamentos.

?Que debo hacer en caso de una sobredosis?

En caso de una sobredosis, llame a la oficina local de control de envenenamiento al 1-800-222-1222. Si la victima esta inconsciente, o no respira, llame inmediatamente al 911.



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Volunteerpro - Expert Training For Volunteer Managers, Volpro

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“Volunteer Pro serves as a nerve center for volunteer managers from all walks of life. There isn’t quite any online community like it because Tobi Johnson has such a wealth of expertise in this area that she is able to curate the community to provide depth and strategy when it comes to designing volunteer based programming. The tone and pace of new and relevant information is on point, the community is insightful and supportive, and the content is spot on when it comes to practical application. You might want to bookmark Volunteer Pro in your browser because the likelihood is, it will be a quick favorite.”

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“These webinars are chock full of solid content and use humor well to make their points. Tobi and Tracey are top notch at what they do. The timeliness of the topics could not be better. I am learning so many skills that are very applicable to my work.”

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Garamat, Betamethasone Sodium Phosphate, Gentamicin Sulfate, Garamat

Garamat

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Short-term treatment of inflammatory eye conditions, when prevention of bacterial infection is also required. Inflammation of the outer ear (otitis externa), when prevention of bacterial infection is also required.

Use with caution in Children. Nasal conditions in people who have recently had nasal surgery. Eye conditions in people with thinning of the cornea or sclera (the tissues which cover the outer surface of the eye). Not to be used in Fungal or viral infections of the eyes, ears or nose. Tuberculosis infection affecting the eye. Eye conditions that are producing pus. Inflammation of the front of the eye (cornea) or the membrane lining the eye (conjunctiva) due to the herpes simplex virus (herpetic keratitis). Glaucoma. Ear conditions in people with a perforated eardrum. Nasal conditions in people with tuberculosis affecting the lungs. These drops should not be used to treat a red eye that has not been diagnosed by a doctor, as inappropriate use can cause blindness. This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect. Possible side effects are listed below. Local irritation, itching, stinging or burning sensation. Temporary blurred vision after putting the drops in the eye(s). Ulceration of the front part of the eye (cornea). Increase in the pressure inside the eye (glaucoma) which may lead to problems with your sight. If used in the eye frequently or for long periods of time, corticosteroids such as this one can cause partial loss of vision due to cloudiness in the lens of the eye (cataracts). Dilated pupils. Drooping of the eyelid. Inflammation of the outer surface of the eye. Possible side effects when the drops are used in the nose are listed below. in the ear are listed below. Local irritation, itching, stinging or burning sensation. Dermatitis. The side effects listed above may not include all of the side effects reported by the medicine’s manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

It is important to tell your doctor or pharmacist what medicines you are already using, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before using any new medicines while using this one, to ensure that the combination is safe. If you are using any other types of eye, ear or nose drop you should administer them at least five minutes apart, to prevent the second drop washing away the first.

may cause your vision to blur temporarily after applying them into the eye. Do not drive or operate machinery until this has worn off. Consult your doctor if after seven days of treatment with this medicine there is little or no improvement in your symptoms. should not be used for longer than seven days, unless under expert supervision. If prolonged therapy is needed, you should have regular check-ups with your doctor so they can monitor you for adverse reactions. After more prolonged treatment (over six to eight weeks), the drops should be withdrawn slowly to avoid relapse of the condition. Intensive or prolonged application of corticosteroids to the eye may lead to an increase in the pressure inside the eye, glaucoma, damage to the optic nerve or the formation of cataracts. Your eye specialist will want you to have regular eye check-ups to monitor for these types of side effects if you use this medicine for long periods of time. Each container of this medicine should discarded four weeks after the first opening, because after this time the drops may be contaminated with germs. You may find it helpful to write the date of opening on the pack. Dispose of carefully, preferably by returning to your pharmacy. Pregnancy and breastfeeding Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine. The safety of this medicine for use during pregnancy and breastfeeding has not been established. It is not recommended for use during pregnancy or breastfeeding. Consult your doctor for further advice.

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Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Alavert is used for relieving symptoms of seasonal allergies.

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FDA pregnancy category B: This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Loratadine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

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Metronidazole

Formula : C 6 H 9 N 3 O 3

Molecular weight : 171.1540

IUPAC Standard InChI: InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3

IUPAC Standard InChIKey: VAOCPAMSLUNLGC-UHFFFAOYSA-N

CAS Registry Number: 443-48-1

Chemical structure: View the 3d structure.

Other names: 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-; Anagiardil; Bayer 5360; Clont; Deflamon; Entizol; Flagesol; Flagil; Flagyl; Gineflavir; Imidazole-1-ethanol, 2-methyl-5-nitro-; Klion; Klont; Metronidazol; Mexibol; Orvagil; RP 8823; Takimetol; Trichomol; Trichopal; Trivazol; Vagimid; 2-Methyl-5-nitroimidazole-1-ethanol; neo-Tric; Acromona; Arilin; Atrivyl; Bexon; Cont; Danizol; Deflamon-Wirkstoff; Efloran; Elyzol; Eumin; Flagemona; Flegyl; Giatricol; Meronidal; Methronidazole; Metronidaz; Monagyl; Monasin; Nalox; Nida; Novonidazol; Sanatrichom; SC 10295; Trichazol; Trichex; Trichocide; Trichomonacid 'pharmachim'; Trichopol; Tricocet; Tricom; Tricowas B; Trikacide; Trikamon; Trikojol; Trikozol; Trimeks; Vagilen; Vertisal; Wagitran; 1-(β-Ethylol)-2-methyl-5-nitro-3-azapyrrole; 1-(β-Hydroxyethyl)-2-methyl-5-nitroimidazole; 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole; 1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole; 1-Hydroxyethyl-2-methyl-5-nitroimidazole; 2-Methyl-1-(2-hydroxyethyl)-5-nitroimidazole; 2-Methyl-3-(2-hydroxyethyl)-4-nitroimidazole; Metronidazolo; NSC-50364; Metro I. V.; Protostat; Satric; Fossyol; Metro cream & gel; MetroGel; Metrolag; Metrolyl; Metrotop; Rathimed; Tricho-gynaedron; Tricho cordes; Zadstat; Cimetrol 500LPCI; Flazol; Metron; Trichobrol; Trikhopol; Polibiotic; 1-(β-Oxyethyl)-2-methyl-5-nitroimidazole; Metronidazole Benzoate; component of Flagyl i. v.; component of Metro i. v.; component of Rtu; 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethanol; Metronidazole - from non-authenticated sample -

Permanent link for this species. Use this link for bookmarking this species for future reference.

Information on this page:

Notes / Error Report

Other data available:

Mass spectrum (electron ionization)

Gas Chromatography

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Data from NIST Standard Reference Database 69: NIST Chemistry WebBook

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Alaska Fish & Wildlife News April 2005

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Researchers Ellis Bacon and Gordon Burghardt of the University of Tennessee concluded that black bears could discriminate between shades of color. Two bears were trained to associate food with a specific color: one bear learned that food was in a blue container, the other identified green. Containers were tightly sealed to prevent olfactory clues.

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Color-blind people can see colors like yellow and blue as different shades of gray, so the study attempted to create hues that would be perceived as homogenous shades of gray.

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Researchers working with captive polar bears at the Philadelphia Zoo concluded that polar bears see in color. The experiment used a discrimination task similar to Bacon and Burghardt’s test, with ice blocks of different colors thrown into the enclosure in pairs. At any given time, one color reliably contained a food treat and the other color was empty.

The bears performed better than guessing would allow, and researchers took steps to make sure that color was the only cue that would signal the right answer. When they had mastered the discrimination, colors were reversed and performance rapidly climbed back to high levels.

Subscribe to Fish and Wildlife News to receive a monthly notice about the new issue and the articles.

Alaska Department of Fish and Game

Alaska Fish & Wildlife News April 2005

Studies indicate that bears do see in color.

Tests with black bears and polar bears indicate that bears can see color.

Researchers Ellis Bacon and Gordon Burghardt of the University of Tennessee concluded that black bears could discriminate between shades of color. Two bears were trained to associate food with a specific color: one bear learned that food was in a blue container, the other identified green. Containers were tightly sealed to prevent olfactory clues.

After learning to associate food with color, bears were tested using identical containers in different shades. The “blue-trained” bear could correctly discern between blue and blue-gray, blue-green, blue-red and blue-yellow; the “green” bear could discriminate between green and similar shades.

Color-blind people can see colors like yellow and blue as different shades of gray, so the study attempted to create hues that would be perceived as homogenous shades of gray.

In the discussion of the project, the researchers commented on comparable studies done with other animals. The authors wrote, “Hue discrimination was clear and contrary to Courtier (1954) and did not depend on bright colors. The task acquisition was very rapid and the discriminations were consistently correct. The bears learned more rapidly than Grether’s (1946) chimpanzees, and as fast as the dogs used by Hosengren (1969). This positive performance indicates that hue discrimination is most likely a strong and widely used component of the bear’s visual perception.”

Researchers working with captive polar bears at the Philadelphia Zoo concluded that polar bears see in color. The experiment used a discrimination task similar to Bacon and Burghardt’s test, with ice blocks of different colors thrown into the enclosure in pairs. At any given time, one color reliably contained a food treat and the other color was empty.

The bears performed better than guessing would allow, and researchers took steps to make sure that color was the only cue that would signal the right answer. When they had mastered the discrimination, colors were reversed and performance rapidly climbed back to high levels.

Subscribe to Fish and Wildlife News to receive a monthly notice about the new issue and the articles.



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Diltiazem calms blood vessels, lowering blood pressure.

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Common side effects of Diltiazem :

Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing. - Headache. - Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. - Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxativ

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

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Alert your doctor if you have kidney, liver or any kind of heart disease. - Alert your doctor if you are pregnant or breastfeeding. Inform your doctor if you become pregnant while being treated with Diltiazem. Do not breastfeed while being treated with Diltiazem.

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If you think there was an overdose, call your local poison control center or ER right away. - Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. A fast heartbeat. Very bad dizziness or passing out. Trouble breathing. Very bad headache. Feeling very tired or weak. Any rash. Side effect or health problem is not better or you are feeling worse.

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Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Therapeutic Classification

This medication is a calcium channel blocker, prescribed for high blood pressure and angina pectoris (chest pain). It works by relaxing the blood vessels.



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Product Description Common use Noroxin is quinolone antibiotic used for treatment of urinary tract such as pyelonephritis, cystitis, urethritis), genitals (prostatitis, cervicitis, endometritis), gastrointestinal tract (salmonellosis, shigellosis), uncomplicated gonorrhea. Mechanism of its action consists in inhibition of DNA gyrase leading to destabilization of the bacterial DNA and death of the susceptible bacteria. Noroxin is active against Staphylococcus spp. (including Staphylococcus aureus), Neisseria spp. E. coli, Citrobacter spp. Klebsiella spp. Proteus spp. Salmonella spp. Enterobacter spp. Hafnia, Shigella spp. Mycobacterium tuberculosis, Vibrio cholerae, Haemophilus influenzae, Chlamydia spp. Mycoplasma spp. and some others. Medication is active for 12 hours.

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Precautions In elderly and patients with kidney impairment, kidney function monitoring is required on a regular basis. This medication may cause photosensibilization, avoid direct sun rays during treatment. Limit consummation of alcoholic beverages as they may worsen such side effects as dizziness, drowsiness and others which may affect your ability to operate machinery and driving.

Contraindications This medication cannot be administered in patients with hypersensitivity to Noroxin, pregnant and breastfeeding women, children under 18 y. o. individuals with glucose-6-phosphate dehydrogenase deficiency. Caution is required when Noroxin is administered in individuals with cerebral arteriosclerosis, cerebrovascular dysfunctions, epilepsy, epileptic syndrome, Myasthenia gravis, kidney or liver failure.

Possible side effect The most common side effects include: weakness, headache, drowsiness, dizziness, nausea, stomach upset. Rare but serious side effects are: tremor and sun sensitivity, seizures, mental/mood changes, sore throat/fever, vision changes, hearing loss, change in amount or appearance of urine, jaundice, fainting, changes in heartbeat, easy bruising or bleeding, numbness or tingling of extremities. Tendon damage and weakening of muscles is rare but possible. Stop exercising and claim prompt medical attention if you experience pain in your joint or tendon. In case of pseudomembranous colitis (persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool) which may develop even a few weeks after the treatment was discontinued, do not use anti-diarrhea products or narcotic pain medications. Tell your doctor immediately about your condition. Prolonged or repeated used of Noroxin may cause oral thrush or a new vaginal yeast infection with such symptoms as: white patches in the mouth, a change in vaginal discharge. Inform your doctor immediately if you experience allergic reaction (severe dizziness, rash, itching, swelling, trouble breathing).

Drug interaction Theophylline dose should be decreased while on Noroxin. Noroxin increases the blood concentration of indirect anticoagulants, cyclosporine, decreases effects of nitrofurans. Antacids which contain ions of Al and Mg, medications which contain Fe, Zn2+, sucralfate should be taken at least with four hour interval with Noroxin. Concomitant intake with the medicines decreasing epileptic threshold may lead to epileptic attacks. Dangerous sudden drop in blood pressure or changes in heart rhythm are possible when Noroxin is concomitantly used with the drugs for blood pressure or affecting the heart rhythm. Inform your doctor about all prescribed and over-the-counter medications and herbal products you are taking.

Missed dose If you miss a dose, take it as soon as you remember unless it is almost time of your next dose. If it is near the time of the next dose, skip the missed dose and return dosing schedule. Do not double the dose to make up the missed dose.

Overdose Symptoms of overdose include: dizziness, nausea, vomiting, drowsiness, "cold" sweating, puffy face without major changes in hemodynamic indices.

Storage Store at room temperature in a tight container, away from moisture and humidity.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.



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Important information - closure notice of Metronet from the 11th January 2016

As you may know, Metronet was bought by Plusnet back in 2005. Over the last ten years you've benefited from our award winning customer service and now we also want to make sure you're getting the best value for money and access to our latest products and packages. That's why we've made the decision to close Metronet and give you, our valued customers, an easy no hassle option to transfer your service to Plusnet.

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We strongly recommend you contact us as soon as possible, as from the 11th January 2016 you will no longer be able to use your Metronet service.

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Prednisolone Dosage

Applies to the following strength(s): tebutate 20 mg/mL ; sodium phosphate 20 mg/mL ; 15 mg/5 mL ; 5 mg ; (as sodium phosphate) 5 mg/5 mL ; sodium phosphate 15 mg/5 mL ; (as sodium phosphate) 25 mg/5 mL ; acetate 50 mg/mL ; acetate 25 mg/mL ; 10 mg ; 15 mg ; 30 mg ; 5 mg/5 mL ; (as sodium phosphate) 10 mg/5 mL ; (as sodium phosphate) 20 mg/5 mL ; acetate ; sodium phosphate ; (as acetate) 15 mg/5 mL

The information at Drugs. com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Multiple Sclerosis

Tablets and syrup for acute exacerbations: 200 mg daily for one week followed by 80 mg every other day for 1 month.

Usual Adult Dose for Bronchopulmonary Dysplasia

Tablets and syrup for acute exacerbations: 200 mg daily for one week followed by 80 mg every other day for 1 month.

Usual Adult Dose for Anti-inflammatory

Oral: 5 to 60 mg per day in divided doses 1 to 4 times/day.

Intravenous or Intramuscular: 4 to 60 mg/day

For intraarticular, intralesional or soft tissue administration : Large joints: 10 to 20 mg Small joints: 4 to 5 mg Bursae: 10 to 15 mg Tendon sheaths: 2 to 5 mg Soft tissue infiltration: 10 to 30 mg Ganglia: 5 to 10 mg

Injectable suspension (tebutate) for intraarticular, intralesional or soft tissue administration : Large joints: 20 to 30 mg (doses > 40 mg not recommended) Small joints: 8 to 10 mg Bursae: 20 to 30 mg Tendon sheaths: 4 to 10 mg Ganglia: 10 to 20 mg

Injectable suspension (acetate) for intraarticular, intralesional or soft tissue administration: 4 to 100 mg Bursae: 10 to 15 mg Tendon sheaths: 2 to 5 mg Soft tissue infiltration: 10 to 30 mg

Usual Pediatric Dose for Immunosuppression

Oral: 0.1 to 2 mg/kg/day in divided doses 1 to 4 times a day.

Intravenous: 0.1 to 2 mg/kg/day in divided doses 1 to 4 times a day.

Usual Pediatric Dose for Asthma - Acute

Oral: 1 to 2 mg/kg/day in divided doses 1 to 2 times a day for 3 to 5 days.

Intravenous: 2 to 4 mg/kg/day divided 3 or 4 times a day.

Usual Pediatric Dose for Nephrotic Syndrome

First 3 episodes: Initial dose: 2 mg/kg/day (maximum dose 80 mg/day) until urine is free of protein for 3 consecutive days (maximum: 28 days); followed by 1 to 1.5 mg/kg/dose every other day for 4 weeks.

Frequent relapses or long-term maintenance dose: 0.5 to 1 mg/kg/dose given every other day for 3 to 6 months.

Usual Pediatric Dose for Bronchopulmonary Dysplasia

2 mg/kg/day orally divided twice daily for 5 days, followed by 1 mg/kg/day once daily for 3 days, followed by 1 mg/kg/dose every other day for 3 doses.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Dosage adjustment should be based on severity of condition treated and response of patient.

Precautions

Avoid abrupt withdrawal after long-term therapy.

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Tobramycin-Dexamethasone Ophthalmic Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, D

tobramycin-dexamethasone ophthalmic

GENERIC NAME(S): TOBRAMYCIN/DEXAMETHASONE

Uses

This medication is used to treat or prevent eye infections. This medication contains two drugs. Tobramycin belongs to a class of drugs called aminoglycoside antibiotics. It works by stopping the growth of bacteria. Dexamethasone belongs to a class of drugs called corticosteroids. It works by reducing swelling.

This medication treats/prevents only bacterial eye infections. It will not work for other types of eye infections. Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

How to use tobramycin-dexamethasone ophthalmic

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface. Shake the bottle well before each dose.

Do not wear contact lenses while you are using this medicine. Sterilize contact lenses according to manufacturer's directions and check with your doctor before you begin using them again.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed, and if your dose is for more than 1 drop. Your dosage is based on your medical condition and response to therapy.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e. g. drops or ointments), wait at least 5 to 10 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day. Continue to use this medication for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Inform your doctor if your condition persists or worsens.

Side Effects

Eye redness, eye discomfort, and eyelid itching /swelling may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Use of this medication for prolonged/repeated periods may result in a new fungal eye infection and may increase your risk for other eye problems (e. g. glaucoma. cataracts ). Do not use this medication for longer than prescribed. Tell your doctor right away if you notice any of the following: new or worsening eye symptoms (e. g. discharge, swelling), vision changes, eye pain .

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using tobramycin with dexamethasone, tell your doctor or pharmacist if you are allergic to either drug; or to other aminoglycoside antibiotics (e. g. gentamicin ); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride ), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems (e. g. glaucoma ).

Your vision may be temporarily unstable after applying this drug. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known if this medication passes into breast milk. Consult your doctor before breast - feeding.

Interactions

Your healthcare professionals (e. g. doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Throw away the unused portion after therapy is completed. Do not use it later for another infection or give it to someone else. A different medication may be necessary in those cases.

If you are using this medication for more than 10 days, laboratory and/or medical tests (e. g. eye exams ) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store the bottle upright at room temperature away from light. Some brands may also be stored in the refrigerator. Check the product package for instructions on how to store your product. If you have any questions about storage, ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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tobramycin-dexamethasone ophthalmic

GENERIC NAME(S): TOBRAMYCIN/DEXAMETHASONE

Uses

This medication is used to treat or prevent eye infections. This medication contains two drugs. Tobramycin belongs to a class of drugs called aminoglycoside antibiotics. It works by stopping the growth of bacteria. Dexamethasone belongs to a class of drugs called corticosteroids. It works by reducing swelling.

This medication treats/prevents only bacterial eye infections. It will not work for other types of eye infections. Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

How to use tobramycin-dexamethasone ophthalmic

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface. Shake the bottle well before each dose.

Do not wear contact lenses while you are using this medicine. Sterilize contact lenses according to manufacturer's directions and check with your doctor before you begin using them again.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed, and if your dose is for more than 1 drop. Your dosage is based on your medical condition and response to therapy.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e. g. drops or ointments), wait at least 5 to 10 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day. Continue to use this medication for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Inform your doctor if your condition persists or worsens.

Side Effects

Eye redness, eye discomfort, and eyelid itching /swelling may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Use of this medication for prolonged/repeated periods may result in a new fungal eye infection and may increase your risk for other eye problems (e. g. glaucoma. cataracts ). Do not use this medication for longer than prescribed. Tell your doctor right away if you notice any of the following: new or worsening eye symptoms (e. g. discharge, swelling), vision changes, eye pain .

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using tobramycin with dexamethasone, tell your doctor or pharmacist if you are allergic to either drug; or to other aminoglycoside antibiotics (e. g. gentamicin ); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride ), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems (e. g. glaucoma ).

Your vision may be temporarily unstable after applying this drug. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known if this medication passes into breast milk. Consult your doctor before breast - feeding.

Interactions

Your healthcare professionals (e. g. doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Throw away the unused portion after therapy is completed. Do not use it later for another infection or give it to someone else. A different medication may be necessary in those cases.

If you are using this medication for more than 10 days, laboratory and/or medical tests (e. g. eye exams ) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store the bottle upright at room temperature away from light. Some brands may also be stored in the refrigerator. Check the product package for instructions on how to store your product. If you have any questions about storage, ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Citracal (Calcium Citrate)

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DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

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Disclaimer: All information deemed reliable but not guaranteed. All properties are subject to prior sale, change or withdrawal. Neither listing broker(s) or information provider(s) shall be responsible for any typographical errors, misinformation, misprints and shall be held totally harmless. Listing(s) information is provided for consumers personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Information on this site was last updated 09/20/2016. The listing information on this page last changed on 09/20/2016. The data relating to real estate for sale on this website comes in part from the Internet Data Exchange program of RMLS (last updated Tue 09/20/2016 4:53:03 PM EST) or Willamette Valley MLS (last updated Tue 09/20/2016 3:50:20 PM EST). Real estate listings held by brokerage firms other than RE/MAX Equity Group may be marked with the Internet Data Exchange logo and detailed information about those properties will include the name of the listing broker(s) when required by the MLS. All rights reserved. --

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How Do I Take Calcitab 600 Webmd Answers, Calcitab

Take this medication by mouth with food. If your product contains calcium citrate, then it may be taken with or without food. Follow all directions on the product package, or take as directed by your doctor. For best absorption, if your daily dose is more than 600 milligrams, then divide your dose and space it throughout the day. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are using the chewable product, chew it well before swallowing.

If you are using the effervescent tablet, allow the tablet to fully dissolve in a glass of water before drinking it. Do not chew or swallow the tablet whole.

If you are using the liquid product or powder, measure the medication with a dose-measuring spoon or device to make sure you get the correct dose. Do not use a household spoon. If the liquid product is a suspension, shake the bottle well before each dose.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

If your doctor has recommended that you follow a special diet, it is very important to follow the diet to get the most benefit from this medication and to prevent serious side effects. Do not take other supplements/vitamins unless ordered by your doctor.

If you think you may have a serious medical problem, seek immediate medical attention.

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