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Doxepin

IMPORTANT WARNING:

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as doxepin during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take doxepin, but in some cases, a doctor may decide that doxepin is the best medication to treat a child's condition.

You should know that your mental health may change in unexpected ways when you take doxepin or other antidepressants even if you are an adult over age 24. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied, abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

Your healthcare provider will want to see you often while you are taking doxepin, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with doxepin. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www. fda. gov/Drugs/DrugSafety/InformationbyDrugClass/UCM096273 .

No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

Why is this medication prescribed?

Doxepin is used to treat depression and anxiety. Doxepin is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed for mental balance.

How should this medicine be used?

Doxepin comes as a capsule, a tablet, or concentrate (liquid) to take by mouth. It is usually taken one to three times a day and may be taken with or without food. Try to take doxepin at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take doxepin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Doxepin concentrate (oral liquid) comes with a specially marked dropper for measuring the dose. Ask your pharmacist to show you how to use the dropper. Dilute the concentrate in 4 ounces (120 mL) of water; whole or skim milk; or orange, grapefruit, tomato, prune, or pineapple juice just before taking it. Do not mix it with carbonated beverages (soft drinks).

It may take several weeks or longer for you to feel the full effect of doxepin. Continue to take doxepin even if you feel well. Do not stop taking doxepin without talking to your doctor. Your doctor will probably want to decrease your dose gradually.

Other uses for this medicine

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking doxepin,

tell your doctor and pharmacist if you are allergic to doxepin, amoxapine, or any other medications.

tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take doxepin. If you stop taking doxepin, you should wait at least 14 days before you start to take an MAO inhibitor.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines; anticoagulants (blood thinners) such as warfarin (Coumadin, Jantoven); cimetidine (Tagamet); flecainide (Tambocor); levodopa (Larodopa, Sinemet); lithium (Eskalith, Lithobid); medication for high blood pressure, seizures, Parkinson's disease, diabetes, asthma, colds, or allergies; methylphenidate (Ritalin); muscle relaxants; propafenone (Rythmol); quinidine; sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); sleeping pills; thyroid medications; tolazamide (Tolinase); and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Your doctor may tell you not to take doxepin if you have taken fluoxetine in the past 5 weeks.

tell your doctor if you have difficulty urinating. Your doctor will probably tell you not to take doxepin.

tell your doctor if you have or have ever had an enlarged prostate (a male reproductive gland), diabetes, seizures, an overactive thyroid gland, or liver, kidney, or heart disease.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking this medication, call your doctor.

talk to your doctor about the risks and benefits of taking doxepin if you are 65 years of age or older. Older adults should not usually take doxepin because it is not as safe or effective as other medications that can be used to treat the same condition.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking doxepin.

you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

remember that alcohol can add to the drowsiness caused by this medication.

you should know that doxepin may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Doxepin may cause side effects. Call your doctor if any of these symptoms are severe or do not go away:

nausea

drowsiness

weakness or tiredness

nightmares

dry mouth

skin more sensitive to sunlight than usual

changes in appetite or weight

constipation

difficulty urinating

frequent urination

changes in sex drive or ability

excessive sweating

If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately:

jaw, neck, and back muscle spasms

slow or difficult speech

shuffling walk

uncontrollable shaking of a part of the body

fever

difficulty breathing or swallowing

rash

yellowing of the skin or eyes

irregular heartbeat

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

Doxepin may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose



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About the drug:

Progesterone is a female hormone that is significant for the regulation of ovulation and menstruation. Whenever women who have not reached menopause yet begin to experience irregular periods, it means that progesterone is lacking from their body. Under such circumstances, this hormone is used to bring about menstrual periods in women. It is effective in avoiding overgrowth in the lining of the uterus in postmenopausal women, who are undergoing estrogen hormone substitution therapy. Your doctor may prescribe the amount of progesterone depending on your condition and prevailing medical history. The dosage differs from patient to patient and there is no fixed or standard amount of dosage. Strictly stick to your prescribed amount of dosage.

Uses of the drug:

To treat the women who have stopped having menstrual periods before menopause

Prevent abnormal thickening of the uterus wall lining

Working of the drug:

Progesterone hormone is lipophilic (lipid-loving) in nature hence gets easily absorbed in the cells. The hormone then binds to the receptors and initiates the progestational activity.

Manufacturer:

Susten 100 mg tablets are manufactured by Sun Pharma, India. You can buy Susten 100 mg online from alldaychemist. com.

Dosage form and strengths:

Progesterone is available on our website in various strengths and dosage form on our website:

Susten 200mg soft gelatin capsule

Susten 200mg/2ml Ampoules

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Susten Gel 1.35 gm

Susten 100 mg tablets

Susten 200 mg tablets

Before you take the drug:

Do not take the drug if you:

Are planning a pregnancy, or if you are within the initial stages of your pregnancy

Are breast-feeding

Are suffering or have earlier suffered from growths in the liver, lupus, migraines, seizures, thyroid problems, fluid retention, swelling of joints, blood clotting, or vision loss

Have a history of asthma, kidney problems, heart problems, high blood pressure, blood vessel problems, high cholesterol or lipid levels, diabetes, depression, dementia, gallbladder problems, or pancreas problems, high or low blood calcium levels.

Tell your doctor if you:

Have been afflicted with jaundice

Have had your uterus removed or if there was a history of endometrial, cervical, or vaginal cancer in your family

Have had suffered from endometriosis; growths in the uterus; uterine fibroids; abnormal mammograms; or lumps in the breast

Dosage:

How much to take the drug?

Progesterone must be administered just how your doctor prescribes it. Whenever in doubt and your doctor can not be reached, follow the instructions on your prescription label.

How to take the drug?

During each menstrual cycle, Progesterone is sometimes given for only a small duration, such as for 6 to 12 days at a time. You must strictly follow the suggested dosing routine for this medication to take effect. Properly take note of the patient instructions that come with this medication very carefully. In case you have any queries, immediately consult your pharmacist or physician. If you are consuming the tablet form of progesterone, take it with a full glass of water. Do not break or crush the tablet, take it as whole.

Miss dose:

Without any hesitation, take the missed dose as soon as you remember it. However, it shouldn't be consumed if it is already time for your next dosage. Never make the mistake of taking any extra medication to make up for the missed doses, as this could create other complications.

Overdose:

Get medical attention at the earliest in case of over dose. Visit your nearest health care center or call your doctor immediately.

Side effects of the drug:

Do not hesitate to seek immediate medical help in case you experience:

Vomiting

Depression

Sleep disturbances

Lethargy

Mood swings

Lack of appetite

Dark urination

Pallid stools

Breast tenderness

Nipple discharge

Increased hair growth

Loss of scalp hair, and freckles or darkening of facial skin

Side effects like hives; difficulty in breathing; or swelling of your face, lips, tongue, might be indications to put this drug on hold for a short period and consult your doctor about any further course of action. In mild instances, you could be prone to sudden coughing; wheezing; rapid breathing; swelling in your hands, ankles, and feet; unnecessary warmth, and redness in one or both leg.

Some other major concerns while consuming this drug are sudden numbness or weakness on one side of the body; sudden and severe migraines; disorientation; indistinct vision or speech; improper balance; chest, arm, stomach, or shoulder pains; nausea; sweating; and general illness. Women could develop irregular menstrual periods, besides experiencing an itching sensation in their vagina or an unusual amount of vaginal discharge. Coughing up blood, suffering from jaundice, developing breast lumps, or losing interest in sex, could be experienced in extreme situations.

Common drug interactions:

Always remember to inform your doctor about all the prescriptions and other medications you take, including vitamins, minerals, herbal products, and other drugs prescribed by other doctors. Never fail to start a new course of this drug without taking your physician's opinion first. The healing capabilities of Progesterone can be severely hampered by some drugs, while some unfavorable outcomes could be produced when taken with other drugs.

Warning:

Things to remember:

Visit your doctor regularly while using this medication and never miss any scheduled appointments

Progesterone must be stored at room temperature and a safe distance from moisture, heat, and light

Do not use this medicine for any other complaints unless your doctor says to do so

Please note that not all medications, including any referenced on this page, are dispensed from our affiliated Indian pharmacy. The medications in your order may be filled and shipped from an approved International fulfilment center located in a country other than India. In addition to dispensing medications from our Indian pharmacy, medication orders are also filled and shipped from international fulfilment centers that are approved by the regulatory bodies from their respective countries.

Medication orders are filled and shipped from approved fulfilment centers around the world including, but not limited to, India, United Kingdom, New Zealand, Mauritius and the United States. The items in your order may be filled and shipped from any one of the above jurisdictions. The products are sourced from various countries as well as those listed above. All of our affiliated fulfilment centers have been approved by the regulatory bodies from their respective countries.

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Omeprazole 40 mg Capsules

Omeprazole (Prilosec ® ) is a medication commonly used for the treatment of duodenal and gastric ulcers, gastroesophageal reflux disease (GERD ), H. pylori infections, and pathological hypersecretory conditions.

An over-the-counter (OTC) version is also available to treat frequent heartburn. Nonprescription omeprazole comes in a 20-mg tablet strength.

The prescription version of this medication comes in the following strengths:

Omeprazole 10 mg capsules

Omeprazole 20 mg capsules

Omeprazole 40 mg capsules

Omeprazole 2.5 mg packets for oral suspension

Omeprazole 10 mg packets for oral suspension.

For the treatment of gastric ulcers, it is generally recommended to take omeprazole 40 mg capsules for four to eight weeks (one tablet, once a day). For duodenal ulcers, the recommended dosage is 20 mg for four to eight weeks.

The recommended omeprazole dose for GERD is 20 mg once daily for up to four weeks. People with pathological hypersecretory conditions usually require higher omeprazole dosages (such as 60 mg once daily).

(Click Omeprazole Dosing to learn about dosing for children and to find out dosing recommendations for other conditions as well, such as for the treatment of erosive esophagitis and H. pylori infections.)

Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD



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Triamteren - Diuretics, Potassium-Sparing Diuretics, Atc C03db02, Triamteril

Triamteren

Triamteren Brand Names Mixture

Apo Triazide Tab (Hydrochlorothiazide + Triamterene)

Dyazide Tab (Hydrochlorothiazide + Triamterene)

Novo-Triamzide (Hydrochlorothiazide + Triamterene)

Nu-Triazide Tab 50 Mg/25 Mg (Hydrochlorothiazide + Triamterene)

Penta-Triamterene HCTZ Tablets (Hydrochlorothiazide + Triamterene)

Pro-Triazide (Hydrochlorothiazide + Triamterene)

Riva-Zide 50/25mg Tablets (Hydrochlorothiazide + Triamterene)

Triamteren Chemical_Formula

Triamteren RX_link

Triamteren fda sheet

Triamteren msds (material safety sheet)

Triamteren Synthesis Reference

Spickett, Timmis, J. Chem. Soc. 1954, 2887 (1958)

Triamteren Molecular Weight

Triamteren Melting Point

Triamteren H 2 O Solubility

Triamteren State

Triamteren LogP

Triamteren Dosage Forms

Triamteren Indication

For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and the nephrotic syndrome; also in steroid-induced edema, idiopathic edema, and edema due to secondary hyperaldosteronism.

Triamteren Pharmacology

Triamterene, a relatively weak, potassium-sparing distal tubule diuretic and antihypertensive, is used in the management of hypokalemia. Triamterene is similar in action to amiloride but, unlike amiloride, increases the urinary excretion of magnesium.

Triamteren Absorption

Rapidly absorbed, with somewhat less than 50% of the oral dose reaching the urine.

Triamteren side effects and Toxicity

No information avaliable

Triamteren Patient Information

Information for Patients

To help avoid stomach upset, it is recommended that the drug be taken after meals.

If a single daily dose is prescribed, it may be preferable to take it in the morning to minimize the effect of increased frequency of urination on nighttime sleep.

If a dose is missed, the patient should not take more than the prescribed dose at the next dosing interval.

Triamteren Organisms Affected

Humans and other mammals



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Plavix - Heart Disease, Greligen

Common use Specifically and actively inhibits aggregation of platelets (clotting) and dilatates coronary vessels. Plavix is used to diminish the risk of heart attacks and strokes caused by blood clots is increased in patients with a recent history of stroke, heart attach and peripheral vascular disease. It is used to prevent ischemic disorders like myocardial infarction, stroke, thrombosis of peripheral arteries and others.

Dosage and direction Plavix should be taken once a day with or without food.

Precautions As Plavix belongs to 'blood thinners' avoid taking it with aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) if your doctor did not recommend you to do it. Contact your doctor if you discovered that you have black or bloody stools, vomit that is similar to coffee grounds or if you cough up blood.

Hypersensitivity, severe liver failure, acute bleeding, ulcer of stomach or duodenum, ulcerous colitis, tuberculosis and other diseases predisposing to bleeding, pregnancy, breastfeeding, neonatal period. Caution should be exercised in patients with moderate liver of kidney failure.

Possible side effect Bleeding in stomach or guts, hemorrhagic stroke, neuropenia, thrombocytopenia, abdominal pain, dyspepsia, gastritis, constipation, ulcers in gastrointestinal tract, diarrhea, allergy.

Drug interaction The combination of Plavix with non-steroidal anti-inflammatory drugs may cause risk of stomach and intestinal bleeding the same as high concentration of Plavix increase concentration of Coumadin if they are used concurrently and lead to excessive bleeding.

Missed dose Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose Symptoms of a overdose are vomiting, feeling exhausted or shortness of breath, and signs of blood in your stools or vomit, diarrhea, rush, itching. In case of serious manifestation of these adverse reactions call your doctor immediately.

Storage Store Plavix tablets and capsules should be stored at room temperature between 15-30 C (59-86 F).

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use Specifically and actively inhibits aggregation of platelets (clotting) and dilatates coronary vessels. Plavix is used to diminish the risk of heart attacks and strokes caused by blood clots is increased in patients with a recent history of stroke, heart attach and peripheral vascular disease. It is used to prevent ischemic disorders like myocardial infarction, stroke, thrombosis of peripheral arteries and others.

Dosage and direction Plavix should be taken once a day with or without food.

Precautions As Plavix belongs to 'blood thinners' avoid taking it with aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) if your doctor did not recommend you to do it. Contact your doctor if you discovered that you have black or bloody stools, vomit that is similar to coffee grounds or if you cough up blood.

Hypersensitivity, severe liver failure, acute bleeding, ulcer of stomach or duodenum, ulcerous colitis, tuberculosis and other diseases predisposing to bleeding, pregnancy, breastfeeding, neonatal period. Caution should be exercised in patients with moderate liver of kidney failure.

Possible side effect Bleeding in stomach or guts, hemorrhagic stroke, neuropenia, thrombocytopenia, abdominal pain, dyspepsia, gastritis, constipation, ulcers in gastrointestinal tract, diarrhea, allergy.

Drug interaction The combination of Plavix with non-steroidal anti-inflammatory drugs may cause risk of stomach and intestinal bleeding the same as high concentration of Plavix increase concentration of Coumadin if they are used concurrently and lead to excessive bleeding.

Missed dose Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose Symptoms of a overdose are vomiting, feeling exhausted or shortness of breath, and signs of blood in your stools or vomit, diarrhea, rush, itching. In case of serious manifestation of these adverse reactions call your doctor immediately.

Storage Store Plavix tablets and capsules should be stored at room temperature between 15-30 C (59-86 F).

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.



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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Isotretinoin is a retinoid (derives from vitamin A, and is found in small quantities naturally in the body) used for the treatment of severe acne. It can be also used in other cases.

Dosage and direction

Take Accutane by mouth with a glass of water, with or without food. Avoid cutting, crushing or chewing this medicine. Do not take the medicine more often than it is prescribed. Do not give up taking it except on the advice of your doctor. It may need time for the medicine to help. Consult your doctor concerning proper dose for you.

Inform your health care professional if you have any allergies or if you have diabetes, osteoporosis or other bone disorders, asthma, heart disease, kidney or liver problems. Avoid taking vitamin supplements that contain vitamin A. Avoid drinking alcohol and smoking while being treated with this medication. Aged people can be more sensitive to side effects of the medicine. Inform your doctor if you are pregnant or breast-feed.

Accutane should not be used by patients having demonstrated a reaction of hypersensitivity to it.

Possible side effects

The most common side effects are drowsiness, constipation, headache, dizziness, vomiting, diarrhea, skin rashes. A very serious allergic reaction rarely occurs. Many people using this medicine do not have serious side effects. Turn to your doctor or pharmacist for more details. In case you notice the effects not listed here, contact your doctor or pharmacist.

Before taking Accutane tell your doctor or chemist of all prescription and non-prescription medicines you are taking. Accutane should not be used with * tetracycline antibiotics * steroids (prednisone and others) * seizure medication such as phenytoin (Dilantin). Turn to your doctor or pharmacist for more details.

If you have missed your dose, take it as soon as you remember. If you see that it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take your dose twice.

If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store your drugs in the bathroom. Keep all drugs away from children and pets.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.



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A Jeff Dufine Retrospective, Dufine

Havasu Goes Gollywood LAKE HAVASU CITY - Townsfolk have gone ga-ga over Hollywood, what with no less than three commercial film pro-* jects shooting on location here in recent weeks. It's enough to keep even the most jaded among us waxing enthusiastic and ardent fans in Golly-wood heaven.

The projects have given residents a glimpse of LA's creative geniuses - singer-musician Jeff DuFine, comic Mark Blankfield of ABC's Fridays, actor Dennis Burkley of Mask fame, and "hunk David Hasselhoff of NBC's Knight Rider (See related story below).

Each of the three projects - a syndicated TV spot, a fantasy-filled music video, and a made-for-TV movie - have - capitalized on the legendary London Bridge and its sun, drenched desert backdrop.

DuFine's Oui-Oui Productions - recently wrapped up location shooting with a huge cast of local extras for what he envisions will be two somewhat bizarre, but no less fanciful and entertaining, music videos slated for release in four to six weeks., DuFine, himself, stars in the video and penned the original. score, which includes the songs "Don't Stop" and "London Bridgey", which is loosely based on the children's game.

Leading cast members included Dennis Burkley, who most recently appeared with Cher as the silent guardian biker in the critically-acclaimed film Mask, which debuted last week in Lake Havasu City. He is also known for his co-starring role as Fred Sanford's partner in ABC's San rd & Son. Ifo

Also featured were Mark Blankfield, the mad pharmacist from Fridays, and Swedish-born actress Katja Bjorlin. -

The filmed videos, now in postproduction at Hollywood-Burbank Studios, were directed by Fridays and Not Necessarily the News writerdirector Tom Kramer, filmed by Ken 'Barrows (who was cinematographer for videos with the likes of Madonna, Chicago and Supertramp), and are being edited by Bill Mashover, Academy Award nominee for Romancing the Stone.

Rock Video, TV Movie be Filmed in Lake Havasu LAKE HAVASU CITY - London Bridge and Lake Havasu will serve as a backdrop to several filmmaking projects either currently in production or scheduled, to get underway in the next several months.

Retail Vision, a Connecticut based production company, completed on-location shooting at the London. Bridge last week for a generic television commercial set for national syndication, 'according to Chamber of Commerce spokesman Barbara Super-Watkins,

The :30 and :60 edited spots will be marketed by Retail Vision to high fashion and jewelry merchandisers.

Oui Oui Productions will also shoot a music video, starring rock singer-musician Jeff DuFine, for MTV on location May 10- 12 in the English Village-London Bridge area, said Super-Watkins.

Leading cast members will include Dennis Burkley, noted for his co-starring role in ABC's "Sanford & Son". The hefty, bearded Burkley is currently featured as the silent guardian biker in the film, "Mask", starring Cher.

Also featured are Mark Blankenfield, the mad pharmacist from ABC's "Fridays", and Swedish actress Katja Bjorlin.

The video will be directed by "Fridays" director, Thomas Kramer; cinematography by Ken Barrows; and edited by Bill Mashover, an Academy Award nominee for "Romancing the Stone", starring Michael Douglas.

The music video will feature the city's historic span as the centerpiece of the world's largest game of "London Bridge", according to its producers.

Since the production calls for a huge cast, the company has put out a call for nearly 50 residents to serve as extras, and is looking for 20 men and women 40 years of age or older, 20 people under 40, and at least seven children from 7-11 years old. Anyone interested should immediately contact Barbara Super-Watkins at the Chamber of Commerce, 8554115.

She said she was grateful to the, city's hospitality industry in assisting with arrangements for room and. board for cast and crews. Harrah Corp. Unlimited and Bill Kucich, general manager of the English Village,' has also cooperated with accommodations and in making, necessary arrangements for location shooting in the village area, Super-Watkins added.



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Minint Pasauline kovos su prostatos veziu diena Valstybine ligoniu kasa prie Sveikatos apsaugos ministerijos (VLK) primena, kaip labai svarbu visiems vyrams laiku apsilankyti pas šeimos gydytoja ir išsitirti del prostatos vezio. Anksti nustatyti šia liga, diagnozuoti ikivezines ligas gali padeti prostatos vezio prevencine programa. Tyrimai privalomuoju sveikatos draudimu (PSD) apdraustiems zmonems apmokami Privalomojo sveikatos draudimo fondo (PSDF) lešomis.

Uzkreciamuju ligu ir AIDS centro (ULAC) duomenimis, šiu metu sausio-rugpjucio menesiais Lietuvoje uzregistruoti 354 (90 proc. didesnis sergamumas nei praeitais metais per ta pati laikotarpi) erkinio encefalito (EE) ir 1477 (20 proc. didesnis sergamumas nei praeitais metais per ta pati laikotarpi) Laimo ligos (LL) atvejai. ULAC medikai informuoja, kad EE ir LL atveju kasmet daugeja. 2016 m. rugpjuti EE susirgo 189 asmenys, o LL – 573. Per ta pati praeitu metu laikotarpi EE sirgo 64 asmenys, o LL – 385. Sergamumas erkiu platinamomis ligomis šiu metu rugpjuti didziausias per paskutinius 5 metus.

Panevezio teritorine ligoniu kasa (TLK) atliko savo veiklos zonos stacionariniu asmens sveikatos prieziuros istaigu (ASPI) priemimo-skubiosios pagalbos paslaugu, suteiktu šiu istaigu priemimo skyriuose, analize. Stacionariniu ASPI, t. y. ligoniniu vadovai pakviesti susipazinti ne tik su šios analizes rezultatais – Panevezio TLK taip pat pateike duomenis, kaip ligoninese vykdyta sveikatos apsaugos ministro rekomendacija ASPI skirtas papildomas lešas iš Privalomojo sveikatos draudimo fondo (PSDF) biudzeto rezervo rizikos valdymo dalies nuo 2016 m. liepos 1 d. naudoti istaigu darbuotoju pagrindinio darbo uzmokescio pastoviajai daliai didinti.

Šaltos rankos ir kojos nera pati maloniausia savijauta, o kaip tik erzinanti, taciau specialistai sako, kad kartais tai gali atskleisti ir rimtu sveikatos sutrikimu. Dauguma zmoniu mano, kad tai susije su sutrikusia kraujotaka, kuri iš tikruju yra viena dazniausiu priezasciu, taciau ji nera vienintele. Kas dar lemia tokia sveikatos bukle, rašoma care2.com.

Ankstyvas senejimas yra viena didziausiu moteru baimiu. Saules spinduliai ir aplinkos tarša daro itaka musu odai, del to atsiranda pigmentines demes, raukšles ir kiti ankstyvo senejimo pozymiai. Puoseledamos grozi, visuomet labiau rupinames veido oda, o pamirštame kakla ir rankas. Tuo tarpu kaklas ir rankos yra tos vietos, kurios labiausiai atspindi musu amziu. Todel ju prieziurai reiketu skirti zymiai daugiau demesio. Tinklapis Econet pateikia efektyvias naturalias priemones, kurias galite pasigaminti pacios.

Sveikatos mokymo ir ligu prevencijos centro Aplinkos sveikatos skyrius primena, kad kiekviena rugseji visose Europos Sajungos šalyse organizuojama Europos judrioji savaite – didziausia darnaus judumo kampanija pasaulyje. Jos renginiai vyksta rugsejo 16–22 d. Rugsejo 22-oji daugelyje Europos miestu tradiciškai skelbiama Diena be automobilio. Šia kampanija siekiama skatinti Europos šaliu vietos valdzios institucijas diegti ir populiarinti darnias transporto sistemas bei paraginti gyventojus išbandyti susisiekimo automobiliais alternatyvas: naudotis visuomeniniu transportu, vaziuoti dviraciais, eiti pesciomis ir taip prisideti prie triukšmo, oro taršos, energijos suvartojimo ir eismo spusciu mazinimo.

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Emzok

Metoprololio tartratas, 50mg, pailginto atpalaidavimo plevele dengtos tabletes

Vartojimas: vartoti per burna Registratorius: TEVA Czech Industries s. r.o. Cekija Receptinis: Receptinis

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1. KAS YRA EMZOK IR NUO KO JIS VARTOJAMAS

Grupe pagal indikacijas Antihipertenzinis vaistas, ? blokatorius.

Apibudinimas Emzok veiklioji medziaga selektyviai blokuoja ?1 adrenoreceptorius. Sis vaistas stipriausiai veikia sirdies raumeni, silpniau – bronchus ir kraujagysles. Jis mazina kraujospudi ir sirdies susitraukimu dazni, taip pat sirdies minutini turi ramybeje ir fizinio kruvio metu.

Indikacijos Emzok vartojamas: kai yra aukstas kraujospudis (arterine hipertenzija); norint isvengti krutines anginos priepuoliu (nepakankamos sirdies raumens kraujotakos sukeliamo krutines skausmo); ilgalaikiam gydymui po uminio miokardo infarkto; sirdies ritmo sutrikimams gydyti; migrenos priepuoliu profilaktikai.

2. KAS ZINOTINA PRIES VARTOJANT EMZOK

Kontraindikacijos Emzok vartoti negalima: jei padidejes jautrumas veikliajai medziagai, i ja panasioms medziagoms arba kuriam nors kitam sio vaisto komponentui; pacientams, sergantiems psoriaze; labai sumazejus sirdies susitraukimu dazniui (kai yra bradikardija); jei sutrikes sirdies impulsu generavimas (sergant sinusinio mazgo silpnumo sindromu); sunkus periferiniu arteriju kraujotakos nepakankamumas; pacientams, sergantiems nesureguliuotu sirdies nepakankamumu; istikus miokardo infarktui, jei labai retas pulsas; jei sistolinis kraujospudis yra zemas; jei sutrikes impulso sklidimas sirdimi (kai yra pirmojo ar antrojo laipsnio atrioventrikuline blokada); jei yra vidutinis ar sunkus sirdies nepakankamumas. Jei moteris yra nescia ar zindo kudiki, tai, ar jai vartoti si vaista, nuspres gydytojas.

Atsargumo priemones Negalima baigti vartoti Emzok staiga. Nutraukti gydyma visais atvejais galima tik palaipsniui, doze mazinant 7-10 dienu. Jei pacientas serga isemine sirdies liga, tai ji, mazinanti doze ir ka tik baigusi vartoti si vaista, turi atidziai stebeti gydytojas. Ypatinga demesi gydytojas turetu skirti pacientams, sergantiems cukriniu diabetu (sis vaistas gali maskuoti sumazejusios cukraus koncentracijos kraujyje simptomus, pavyzdziui, drebuli ir sirdies susitraukimu daznio padidejima), taip pat jei yra ar buvo pablogejusi kvepavimo organu (pvz. sergant plauciu emfizema ar letiniu bronchitu), sirdies (pvz. sergant sirdies nepakankamumu), kraujagysliu, inkstu ar kepenu funkcija. Emzok negalima vartoti kartu su verapamiliu, kadangi kyla sirdies sustojimo pavojus. Jei ruosiates operacijai ar del kitokios priezasties vykstate i ligonine, apie Emzok vartojima informuokite gydytoja. Emzok gali tureti nepalankios itakos veiklai, kuriai reikia sutelkto demesio, judesiu koordinacijos ir gebejimo greitai priimti sprendimus (pvz. vairuojant motorine transporto priemone, dirbant su technika, dideliame aukstyje ir pan.). Tokius darbus galima dirbti tik gydytojui leidus. Jei perdozavote sio vaisto, arba jei jo atsitiktinai nurijo vaikas, nedelsdami pasikonsultuokite su gydytoju.

Saveika Emzok ir kartu su juo vartojami vaistai gali tureti itakos vieni kitu poveikiui, todel apie visus vaistus, kuriuos vartojate ar ruosiates vartoti kartu, reikia informuoti gydytoja. Jei, besigydydami Emzok, norite pradeti vartoti kuri nors be recepto parduodama vaista, pasikonsultuokite su gydytoju. Kartu vartojant emzoka ir kitus kraujospudzio mazinamuosius vaistus, dazniausiai kraujospudis sumazeja dar labiau. Emzok negalima vartoti kartu su verapamiliu, kadangi kyla sirdies sustojimo pavojus. Kartu su kitais ? blokatoriais, gangliju blokuojamaisiais vaistais ar MAO inhibitoriais emzoka galima vartoti tik sunkiais atvejais atidziai stebint gydytojui. Jei sis vaistas vartojamas kartu su klonidinu (pastarasis skirtas padidejusiam kraujospudziui mazinti), ir ju abieju vartojima reikia nutraukti, pirmiausia reiketu palaipsniui baigti Emzok vartojima (kitaip gali istikti hipertenzine krize ). Ypac atsargiai Emzok vartojamas kartu su ergotaminu, ? simpatomimetikais ir ? simpatomimetikais. Vaistai, kurie didina fermentu sinteze (pvz. barbituratai ir rifampicinas) gali sukelti Emzok koncentracijos kraujyje sumazejima ir todel susilpninti jo poveiki. Cimetidinas (vaistas gydyti ligoms, susijusioms su padidejusia rugsties sekrecija skrandyje) veikia priesingai. Nesteroidiniai vaistai nuo uzdegimo (pvz. indometacinas) gali susilpninti Emzok kraujospudzio mazinamaji poveiki.

3. KAIP VARTOTI EMZOK

Dozavimas Emzok skirtas tik suaugusiems pacientams. Tikslu dozavima ir vartojimo trukme nurodo gydytojas. Padidejusiam kraujospudziui mazinti ir krutines anginai gydyti paprastai vartojama 50-200 mg viena karta per para. Kai sirdies veikla nereguliari (aritmija ), paprastai vartojama 100-200 mg viena karta per para. Po sirdies vainikiniu arteriju suntavimo operaciju galinciu atsirasti supraventrikuliniu aritmiju profilaktikai galima vartoti 50 mg viena karta per para. Palaikomajam gydymui po sirdies priepuolio paprastai vartojama 200 mg viena karta per para. Migrenos profilaktikai paprastai vartojama 100-200 mg viena karta per para. Vartojimo budas Sios pailginto atpalaidavimo tabletes geriamos viena karta per para, geriausia anksti ryta. I maitinimasi atsizvelgti nereikia. Tablete reikia uzgerti bent puse stiklines vandens. Ja galima perlauzti, taciau negalima kramtyti ar traiskyti.

4. galimAS SALUTINIS poveikiS

Emzok toleruojamas gerai, taciau kai kuriems ji vartojantiems pacientams gali pasireiksti nepageidaujamu poveikiu. Paprastai jie buna nesunkus ir, sumazinus doze, isnyksta. Dazniausi nepageidaujami poveikiai yra galvos svaigimas. mieguistumas, virskinimo sutrikimai (pykinimas, vemimas, pilvo skausmas) ir miego sutrikimai. Be to, gali skaudeti galva ar raumenis, atsirasti depresija. sutrikti demesio sutelkimas ar sirdies ritmas, sumazeti sirdies susitraukimu daznis (bradikardija), atsirasti sirdies plakimo pojutis, sutrikti kvepavimas, isberti oda, sutrikti rega, prasideti plauku slinkimas (galimas net nuplikimas – alopecija), sutrikti kraujo gamyba, priaugti svorio. Sis vaistas yra selektyvus ? blokatorius (stipriausiai veikia sirdies raumeni, silpniau – bronchus ir kraujagysles), taciau kai kuriems pacientams, sergantiems bronchu ligomis, jis gali sukelti kvepavimo taku susiaurejima ir dar labiau trikdyti kvepavima. Jei pasireiskia kuris nors auksciau nurodytas arba kitoks nepageidaujamas poveikis, apie tai reiketu informuoti gydytoja.

5. EMZOK laikymo SALYGOS

Laikyti ne aukstesneje kaip 30 ?C temperaturoje.

Perspejimai Pasibaigus ant pakuotes nurodytam tinkamumo laikui, sio vaisto vartoti negalima. Laikyti vaikams nepasiekiamoje ir nepastebimoje vietoje.

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1. VAISTINIO PREPARATO PAVADINIMAS

EMZOK 50 mg pailginto atpalaidavimo plevele dengtos tabletes EMZOK 100 mg pailginto atpalaidavimo plevele dengtos tabletes EMZOK 200 mg pailginto atpalaidavimo plevele dengtos tabletes

2. KOKYBINE IR KIEKYBINE SUDETIS

Pailginto atpalaidavimo plevele dengtoje tableteje yra 50 mg, 100 mg arba 200 mg metoprololio tartrato.

Pailginto atpalaidavimo plevele dengtos tabletes. Emzok (50 mg) – baltos pailgos tabletes. Abejose pusese yra vagele tabletei perlauzti. Emzok (100 mg) – baltos apvalios abipus isgaubtos tabletes. Vienoje puseje iskilusi zyma “100”. Abejose pusese yra vagele tabletei perlauzti. Emzok (200 mg) – baltos apvalios abipus isgaubtos tabletes. Abejose pusese yra vagele tabletei perlauzti.

4. KLINIKINE INFORMACIJA

4.1. Terapines indikacijos Arterine hipertenzija. Letine stabili krutines angina . Antrine miokardo infarkto profilaktika. Sirdies aritmijos (ypac supraventrikuline tachiaritmija). Migrenos profilaktika.

4.2. Dozavimas ir vartojimo metodas

Emzok skirtas tik suaugusiems pacientams. Plevele dengtos pailginto atpalaidavimo Emzok tabletes vartojamos viena karta per para, geriausia ryte (pusryciaujant ar kitu metu). Plevele dengta pailginto atpalaidavimo tablete galima perlauzti, taciau negalima kramtyti ar traiskyti. Tablete nuryjama uzgeriant bent puse stiklines skyscio. Doze parenkama individualiai ir koreguojama taip, kad nepasireikstu bradikardija. Rekomenduojamas dozavimas nurodytas zemiau. Arterine hipertenzija – 50-200 mg viena karta per para. Letine stabili krutines angina – 100-200 mg viena karta per para (jeigu poveikis nepakankamas – papildomai skirti kitu vaistu). Antrine miokardo infarkto profilaktika – 200 mg viena karta per para. Aritmija – 100-200 mg viena karta per para. Po sirdies vainikiniu arteriju suntavimo operaciju galinciu atsirasti supraventrikuliniu aritmiju profilaktikai gali buti veiksminga ir 50 mg metoprololio paros doze. Migrenos profilaktika – 100-200 mg viena karta per para. Pacientams, sergantiems inkstu nepakankamumu, dozes koreguoti nereikia. Pacientams, kuriems atliekamos hemodializes, dozes koreguoti nereikia. Pacientams, sergantiems kepenu nepakankamumu, reikia mazinti doze, kadangi biologinis prieinamumas yra didesnis. Doze priklauso nuo klinikines situacijos. Senyviems zmonems dozes koreguoti nereikia. Jei reikia baigti Emzok vartojima, tai, jei imanoma, daroma laipsniskai, per 7-10 dienu, kadangi kitaip gali pasunketi krutines anginos simptomai, kyla miokardo infarkto pavojus. Jei Emzok vartojimas baigiamas pries operacija, paskutine sio vaisto doze geriama likus ne maziau kaip 48 val. isskyrus ypatingus atvejus (tirotoksikoze ir feochromocitoma).

Emzok negalima vartoti zemiau nurodytais atvejais. Psoriaze. Sokas (kardiogeninis). Miokardo infarktas. jeigu: – sirdies susitraukimu daznis < 45 kartai per minute; – yra antrojo ar treciojo laipsnio atrioventrikuline blokada; – PR intervalas EKG > 0,24 sek.; – sistolinis kraujospudis < 100 mm Hg; – yra vidutinis ar sunkus sirdies nepakankamumas. Dekompensuotas sirdies nepakankamumas. Antrojo ar treciojo laipsnio atrioventrikuline blokada. Sunki sinusine bradikardija. Sunkus periferiniu arteriju kraujotakos nepakankamumas. Sinusinio mazgo silpnumo sindromas . Padidejes jautrumas bent vienam vaisto komponentui.

4.4. Specialus ispejimai ir atsargumo priemones

Emzok gali sukelti bradikardija, periferines arterines kraujotakos sutrikimu simptomus ir anafilaksini soka. ? blokatoriu vartojimo nepatartina baigti staiga. Jei reikia baigti Emzok vartojima, ta reiketu daryti laipsniskai, per 7-10 dienu. Siuo laikotarpiu ir iskart po to pacienta reiketu atidziai stebeti, ypac jeigu jis serga isemine sirdies liga. Emzok galima skirti kompensavus sirdies nepakankamuma. Jei anksciau buvo pasireiskes sirdies nepakankamumas, arba jei zinoma, kad sirdies rezervas yra mazas, gali buti tikslinga digitalizuoti ir (ar) skirti diuretiku. Sirdziai selektyviu ? blokatoriu poveikis plauciu funkcijai gali buti silpnesnis negu neselektyviu ? blokatoriu, taciau ju (kaip ir kitu ? blokatoriu) nereiketu skirti pacientams, sergantiems ligomis su griztamojo pobudzio kvepavimo taku obstrukcija (isskyrus atvejus, kai ta daryti vercia klinikines aplinkybes). Kai kuriems tokiems pacientams, kuriems butina vartoti ? blokatoriu, kartu gali buti tikslinga skirti bronchu pleciamojo ?2 agonisto (pvz. terbutalino). Pacientams, sergantiems labiliu ar nuo insulino priklausomu cukriniu diabetu, gali reiketi koreguoti gliukozes koncentracija mazinanciu vaistu dozavima. Pacientams, sergantiems feochromocitoma. kartu reiketu skirti ? blokatoriu. Pacientams, sergantiems kepenu ciroze, metoprololio biologinis prieinamumas gali buti didesnis. Kai uzblokuoti ? receptoriai, adrenalinas gali sukelti kraujospudzio padidejima ir bradikardija. Vartojant selektyvius ?1 blokatorius, tokio poveikio tikimybe yra mazesne. Jei numatoma bendroji anestezija, apie metoprololio vartojima butina informuoti anesteziologa. Jei manoma, kad metoprololio vartojima pageidautina baigti, tai, jei imanoma, paskutine sio vaisto doze geriama iki bendrosios anestezijos likus ne maziau kaip 48 val. Vis delto kai kuriems pacientams gali buti tikslinga skirti ? blokatoriu premedikacijai. ? blokatoriai mazina streso poveiki sirdziai, todel gali ja apsaugoti nuo del per stiprios simpatines stimuliacijos kylanciu sirdies aritmiju ar uminio vainikines kraujotakos nepakankamumo. Jei tokiu tikslu skiriamas ? blokatorius, tai norint, kad miokardo funkcijos susilpnejimo pavojus butu mazesnis, reiketu pasirinkti anestetika, kurio neigiamas inotropinis poveikis yra silpnas.

4.5. Saveika su kitais vaistiniais preparatais ir kitokia saveika

Emzok ir kitu antihipertenziniu vaistu poveikis kraujospudziui paprastai sumuojasi, todel reikia imtis atsargumo priemoniu norint isvengti hipotenzijos. Vis delto padidejusiam kraujospudziui mazinti daznai veiksmingi antihipertenziniu vaistu deriniai. Metoprololis gali sumazinti miokardo susitraukimu jega ir sutrikdyti sirdies laiduma. Jei kartu su juo skiriama kitu panasiai veikianciu vaistu (pvz. antiaritminiu, bendruju anestetiku), reikia imtis atsargumo priemoniu. Emzok (kaip ir kitu ? blokatoriu) nereiketu skirti kartu su verapamiliu, kadangi toks derinys gali sukelti bradikardija, hipotenzija ir asistolija. Kartu su simpatiniu gangliju blokuojamaisiais vaistais, kitais ? blokatoriais (pvz. akiu lasais) ar MAO inhibitoriais ? blokatoriu taip pat skiriama atsargiai. Jei reikia nutraukti kartu vartojama klonidina, Emzok vartojima reiketu baigti keliomis dienomis anksciau. ? blokatoriai gali nepalankiai veikti periferine kraujotaka, todel kartu su panasiai veikianciais vaistais (pvz. ergotaminu) ju skiriama atsargiai. Emzok silpnina nuo ?1 adrenoreceptoriu stimuliacijos priklausomus simpatomimetiku poveikius, taciau, kai vartojamas iprastinemis terapinemis dozemis, bronchu pleciamaji ?2 agonistu poveiki turetu veikti mazai. Fermentu induktoriai (pvz. rifampicinas) gali sukelti metoprololio koncentracijos plazmoje sumazejima, o fermentu inhibitoriai (pvz. cimetidinas) – padidejima. Metoprololis gali trikdyti lignokaino (lidokaino) eliminacija. Indometacinas gali susilpninti ? blokatoriu antihipertenzini poveiki. Maistas neturi reiksmingos itakos Emzok farmakokinetikai.

4.6. Nestumas ir zindymas

Nesciosioms ir zindyvems Emzok nereiketu vartoti, isskyrus tuos atvejus, kai, gydytojo nuomone, laukiamas gydomasis poveikis yra didesnis uz galima pavoju vaisiui ar kudikiui. Nestumas. Likus 48-72 val. iki numatomo gimdymo, Emzok vartojima reiketu nutraukti, kadangi kitaip naujagimiui kyla bradikardijos, hipotenzijos ir hipoglikemijos pavojus. Jei nutraukti Emzok vartojima neimanoma, 48-72 val. po gimimo naujagimi reiketu atidziai stebeti. Metoprololio patenka per placenta, jo randama virksteles kraujyje, taciau irodymu, kad jis sukeltu vaisiaus anomaliju, nera. Laktacija. Jei motina vartoja metoprololi iprastinemis terapinemis dozemis, su jos pienu nurytas metoprololio kiekis reiksmingos ? receptoriu blokados kudikiui neturetu sukelti.

4.7. Poveikis gebejimui vairuoti ir valdyti mechanizmus

Priklausomai nuo individualus jautrumo metoprololiui, gali sutrikti gebejimas vairuoti transporto priemone ir dirbti su technika, ypac gydymo pradzioje ar kartu vartojant alkoholinius gerimus.

4.8. Nepageidaujami poveikiai

Nepageidaujami poveikiai paprastai buna lengvi, ju pasireiskia nedaznai. Dazniausi nepageidaujami poveikiai yra nuovargis, virskinimo sutrikimai (pykinimas, vemimas ar pilvo skausmas) ir miego sutrikimai (nemiga, naktiniai kosmarai). Daugeliu atveju sie poveikiai buna trumpalaikiai arba isnyksta sumazinus doze. Kartais pasireiskia nepageidaujamu poveikiu CNS – tai galvos svaigimas. galvos skausmas, retais atvejais parestezija, meslungis, depresija ir budrumo sumazejimas. Aprasyta atskiru atveju, kai atsirado asmenybes sutrikimu (haliucinaciju). Kartais pasireiskia nepageidaujamu poveikiu sirdies ir kraujagysliu sistemai – tai bradikardija, ortostatine hipotenzija, retais atvejais sirdies nepakankamumas, palpitacija, aritmija. Raynaud sindromas, periferine edema ir skausmas sirdies plote. Taip pat aprasyta atskiru atveju, kai sutriko sirdies laidumas ir (pacientams, kuriems jau iki tol periferine kraujotaka buvo sunkiai sutrikusi) prasidejo gangrena. Dazni virskinimo sutrikimai aprasyti auksciau. Be to, retais atvejais gali prasideti viduriavimas. atsirasti viduriu uzkietejimas. Aprasyta atskiru atveju, kai dziuvo burna, atsirado kepenu funkcijos rodikliu anomaliju. Retais atvejais isberia oda (dilgeline. i psoriaze panasus pokyciai, distrofiniai odos pokyciai). Aprasyta atskiru padidejusio jautrumo sviesai, padidejusio prakaitavimo ir alopecijos atveju. Poveikiai kvepavimo sistemai – tai kartais atsirades dusulys fizinio kruvio metu, taip pat reti bronchu spazmo ir atskiri rinito atvejai. Aprasyta atskiru atveju, kai padidejo svoris, pasireiske trombocitopenija. leukopenija, sutriko regejimas, atsirado konjunktyvitas. uzimas ausyse, akiu suerzinimas ir sausumas. Dauguma atveju odos berimo ir akiu dziuvimo simptomai isnykdavo baigus vartoti vaista. Jei negalima rasti kitos tokiu reakciju priezasties, vaisto vartojima tikslinga baigti.

Apsinuodijimas perdozavus metoprololio gali sukelti sunkia hipotenzija, sinusine bradikardija, atrioventrikuline blokada, sirdies nepakankamuma, kardiogenini soka, sirdies sustojima, bronchu spazma, samones sutrikimu, koma, pykinima, vemima, cianoze, hipoglikemija ir (kartais) hiperkalemija. Isgerus per didele doze, pirmieji apsinuodijimo reiskiniai paprastai atsiranda po 20-120 min.

Gydymas. Reiketu atidziai stebeti sirdies ir kraujagysliu, kvepavimo ir inkstu funkcija, taip pat gliukozes ir elektrolitu koncentracija kraujyje. Jei apsinuodijus praejo nedaug laiko, tolesne vaisto rezorbcija galima sustabdyti sukelus vemima, isplovus skrandi ar davus gerti aktyvuotosios anglies. Sirdies ir kraujagysliu sistemos komplikacijas reiketu gydyti simptominemis priemonemis: gali reiketi simpatomimetiku (pvz. noradrenalino, metaraminolio), atropino ar sirdies susitraukimus stiprinanciu vaistu (pvz. dopamino, dobutamino). Jei yra atrioventrikuline blokada, gali reiketi laikino sirdies stimuliavimo. Stiprios ? receptoriu blokados sukeltus poveikius gali pasalinti gliukagonas (1-10 mg i vena). Bronchu spazmui salinti gali reiketi ?2 agonistu (pvz. terbutalino) i vena. Hemodialize efektyviai pasalinti metoprololio negali.

5. FARMAKOLOGINES SAVYBES

5.1. Farmakodinamines savybes

Grupe pagal indikacijas – antihipertenzinis vaistas, ? blokatorius. Pagrindiniai metoprololio poveikiai priklauso nuo konkurencinio antagonizmo ? adrenoreceptoriams. Sis vaistas pasirinktinai veikia ?1 adrenoreceptorius, todel yra reliatyviai selektyvus sirdziai. Metoprololis neturi vidinio simpatomimetinio (dalinio agonistinio) aktyvumo ir beveik nestabilizuoja membranu. Metoprololis blokuoja ?1 adrenoreceptorius, todel, pavartojus sio vaisto, sumazeja sirdies susitraukimu daznis, minutinis turis ir sistolinis kraujospudis. Manoma, kad metoprololio sukeliama ilgalaiki kraujospudzio sumazejima lemia laipsniskas suminio periferinio pasipriesinimo mazejimas. Trumpalaikis ir ilgalaikis metoprololio vartojimas mazina renino aktyvuma plazmoje. Manoma, kad sis poveikis bent is dalies priklauso nuo inkstuose esanciu ?1 adrenoreceptoriu blokados, del kurios sumazeja renino sinteze inkstuose ir susilpneja angiotenzino sukeliamas kraujagysliu susiaurejimas. Is dalies kraujospudzio sumazejimas gali priklausyti nuo renino aktyvumo plazmoje mazinimo. Pacientams, sergantiems hipertenzija, ilgalaikis greito atsipalaidavimo metoprololio vartojimas sukele statistiskai reiksminga kairiojo skilvelio svorio sumazejima. Metoprololis (kaip ir ? adrenoreceptoriu antagonistai) mazina deguonies poreiki miokarde, kadangi mazina sistemini arterini kraujospudi, sirdies susitraukimu dazni ir jega. Sumazejus sirdies susitraukimu dazniui ir prailgejus diastolei, gali pagereti blogai perfuzuojamu miokardo sriciu aprupinimas krauju ir deguonimi, todel sis vaistas vartojamas sergant krutines angina . Metoprololis yra selektyvus ?1 adrenoreceptoriu antagonistas, todel kelia mazesni bronchu spazmo pavoju negu neselektyvus ? blokatoriai (dauguma plauciuose esanciu ? receptoriu yra ?2 tipo).

5.2. Farmakokinetines savybes

Metoprololio tartratas yra vandenyje gerai tirpi druska. Beveik visas metoprololis rezorbuojasi virskinimo trakte, taciau del ekstensyvaus priessisteminio metabolizmo jo sisteminis biologinis prieinamumas yra mazesnis kaip 50 proc. Sis vaistas rezorbuojasi letai, didziausia koncentracija susidaro mazdaug po 6 val. Po to mazdaug 6 val. buna plato faze, o veliau koncentracija pradeda letai mazeti (laikas, per kuri koncentracija sumazeja per puse yra mazdaug 8-12 val.). Metoprololis ekstensyviai pasiskirsto ivairiuose audiniuose ir turi dideli pasiskirstymo turi (5,6 l/kg). Vartojant 800 mg metoprololio ir maziau, jo farmakokinetika yra linijine (rodikliai priklauso nuo dozes). Metoprololio metabolitai (O-demetilmetoprololis ir ?-hidroksimetoprololis) susidaro kepenyse katalizuojant citochromo P450 fermentu sistemai. Jie esti minimalaus aktyvumo ir issiskiria su slapimu. Metoprololio koncentracijos plazmoje kitimas, priklausomai nuo laiko, yra tipiskas pailginto atsipalaidavimo formoms. Letai rezorbuojantis metoprololiui, po 4-6 val. pasiekiama plokscia plato faze (didziausia koncentracija, isgerus vienkartine doze, buna 37,4 ng/ml, esant pastoviai koncentracijai – 54,7 ng/ml), kuri trunka kelias valandas. Po to koncentracija plazmoje letai mazeja. Tariamasis laikas, per kuri vaisto koncentracija sumazeja per puse, yra 6-12 val. (gerokai ilgesnis negu paprastojo metoprololio laikas, kuris priklauso tik nuo paties vaisto savybiu ir yra apie 3 val). Tai rodo, kad nustatytas pailginto atsipalaidavimo metoprololio laikas, per kuri koncentracija sumazeja per puse, labiau atspindi ne tik tikraja eliminacija, bet ir rezorbcija flip-flop (vienu metu vyksta abu sie procesai).

5.3. Ikiklinikiniu saugumo tyrimu duomenys

Su ivairiomis gyvunu rusimis atlikti letinio toksiskumo tyrimai, skiriant metoprololio terapinemis dozemis, su siuo vaistu susijusiu toksiniu poveikiu neparode. Su pelemis ir ziurkemis atlikti kancerogeniskumo tyrimai kancerogeninio poveikio neparode. Tai atitinka mutageniskumo tyrimu rezultatus (potencialaus mutageninio poveikio nenustatyta). Su dviem rusimis (ziurkemis ir triusiais) atlikti tyrimai potencialaus metoprololio teratogeninio poveikio neparode.

6. FARMACINE INFORMACIJA

6.1. Pagalbiniu medziagu sarasas

Mikrokristaline celiulioze, koloidinis bevandenis silicio dioksidas, povidonas, polietileno oksidas, natrio stearilfumaratas, hipromelioze, talkas, makrogolis 6000, antioksidantas E 321, daziklis (titano dioksidas E 171).

6.2. Nesuderinamumai Nera.

6.3. Tinkamumo laikas

6.4. Specialiosios laikymo salygos

Laikyti ne aukstesneje kaip 30 ?C temperaturoje.

6.5. Pirmines pakuotes pobudis ir turinys

30 tableciu 3 lapeliai po 10 tableciu permatomuose polivinilchloridiniuose-polivinilidenchloridiniuose-aliumininiuose lapeliuose (dezuteje). 100 tableciu 100 tableciu polipropileniniame buteliuke su mazo tankio polietileno dangteliu.

10 lapeliu po 10 tableciu permatomuose polivinilchloridiniuose-polivinilidenchloridiniuose-aliumininiuose lapeliuose (dezuteje). Lapeliai ar buteliukai su etiketemis fasuojami i dezutes kartu su informaciniais lapeliais.

6.6. Vartojimo ir darbo su vaistiniu preparatu instrukcija

Pateikiama naujausia informacija apie vaista galite pasitikrinti svetaineje www. vvkt. lt

Spauskite ant pasirinkto raktinio zodzio ir raskite visa, su juo susijusia informacija apie vaistus, ligas, straipsnius, formumo temas bei gydytoju atsakymus.

Minint Pasauline kovos su prostatos veziu diena Valstybine ligoniu kasa prie Sveikatos apsaugos ministerijos (VLK) primena, kaip labai svarbu visiems vyrams laiku apsilankyti pas šeimos gydytoja ir išsitirti del prostatos vezio. Anksti nustatyti šia liga, diagnozuoti ikivezines ligas gali padeti prostatos vezio prevencine programa. Tyrimai privalomuoju sveikatos draudimu (PSD) apdraustiems zmonems apmokami Privalomojo sveikatos draudimo fondo (PSDF) lešomis.

Uzkreciamuju ligu ir AIDS centro (ULAC) duomenimis, šiu metu sausio-rugpjucio menesiais Lietuvoje uzregistruoti 354 (90 proc. didesnis sergamumas nei praeitais metais per ta pati laikotarpi) erkinio encefalito (EE) ir 1477 (20 proc. didesnis sergamumas nei praeitais metais per ta pati laikotarpi) Laimo ligos (LL) atvejai. ULAC medikai informuoja, kad EE ir LL atveju kasmet daugeja. 2016 m. rugpjuti EE susirgo 189 asmenys, o LL – 573. Per ta pati praeitu metu laikotarpi EE sirgo 64 asmenys, o LL – 385. Sergamumas erkiu platinamomis ligomis šiu metu rugpjuti didziausias per paskutinius 5 metus.

Panevezio teritorine ligoniu kasa (TLK) atliko savo veiklos zonos stacionariniu asmens sveikatos prieziuros istaigu (ASPI) priemimo-skubiosios pagalbos paslaugu, suteiktu šiu istaigu priemimo skyriuose, analize. Stacionariniu ASPI, t. y. ligoniniu vadovai pakviesti susipazinti ne tik su šios analizes rezultatais – Panevezio TLK taip pat pateike duomenis, kaip ligoninese vykdyta sveikatos apsaugos ministro rekomendacija ASPI skirtas papildomas lešas iš Privalomojo sveikatos draudimo fondo (PSDF) biudzeto rezervo rizikos valdymo dalies nuo 2016 m. liepos 1 d. naudoti istaigu darbuotoju pagrindinio darbo uzmokescio pastoviajai daliai didinti.

Šaltos rankos ir kojos nera pati maloniausia savijauta, o kaip tik erzinanti, taciau specialistai sako, kad kartais tai gali atskleisti ir rimtu sveikatos sutrikimu. Dauguma zmoniu mano, kad tai susije su sutrikusia kraujotaka, kuri iš tikruju yra viena dazniausiu priezasciu, taciau ji nera vienintele. Kas dar lemia tokia sveikatos bukle, rašoma care2.com.

Ankstyvas senejimas yra viena didziausiu moteru baimiu. Saules spinduliai ir aplinkos tarša daro itaka musu odai, del to atsiranda pigmentines demes, raukšles ir kiti ankstyvo senejimo pozymiai. Puoseledamos grozi, visuomet labiau rupinames veido oda, o pamirštame kakla ir rankas. Tuo tarpu kaklas ir rankos yra tos vietos, kurios labiausiai atspindi musu amziu. Todel ju prieziurai reiketu skirti zymiai daugiau demesio. Tinklapis Econet pateikia efektyvias naturalias priemones, kurias galite pasigaminti pacios.

Sveikatos mokymo ir ligu prevencijos centro Aplinkos sveikatos skyrius primena, kad kiekviena rugseji visose Europos Sajungos šalyse organizuojama Europos judrioji savaite – didziausia darnaus judumo kampanija pasaulyje. Jos renginiai vyksta rugsejo 16–22 d. Rugsejo 22-oji daugelyje Europos miestu tradiciškai skelbiama Diena be automobilio. Šia kampanija siekiama skatinti Europos šaliu vietos valdzios institucijas diegti ir populiarinti darnias transporto sistemas bei paraginti gyventojus išbandyti susisiekimo automobiliais alternatyvas: naudotis visuomeniniu transportu, vaziuoti dviraciais, eiti pesciomis ir taip prisideti prie triukšmo, oro taršos, energijos suvartojimo ir eismo spusciu mazinimo.

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Femara - Woman S Health, Femaplex

Common use Femara is an oral, anti-estrogen drug which lowers estrogen levels in postmenopausal women to prevent certain types of breast cancer.

Dosage and direction The recommended dose of Femara in adults and elderly patients is 2.5 mg once a day. Take with a full glass of water with or without a meal. Follow all recommendations of your doctor. Your doctor may need you to be tested on a regular basis to control effectiveness of this medication. Do not miss any appointments. Your bone mineral density may also need a regular testing.

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Drug interaction Concomitant use of Femara and tamoxifen by a daily dose of 20 mg leads to decrease of letrozole in blood concentrations. Caution should be exercised when letrozole is used together with drugs metabolized by cytochrome P450 isoenzymes (2A6 and 2S19). Inform your doctor about all medications, herbal products, food supplements and vitamins you use.

Missed dose If you missed a dose take it as soon as you remember. If it is almost time for your next dose just skip it and return to your regular schedule. Never take extra or double dose of Femara.

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Storage Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use Femara is an oral, anti-estrogen drug which lowers estrogen levels in postmenopausal women to prevent certain types of breast cancer.

Dosage and direction The recommended dose of Femara in adults and elderly patients is 2.5 mg once a day. Take with a full glass of water with or without a meal. Follow all recommendations of your doctor. Your doctor may need you to be tested on a regular basis to control effectiveness of this medication. Do not miss any appointments. Your bone mineral density may also need a regular testing.

Precautions Inform your doctor if you have liver disease as you may need a dose adjustment or special safety tests. Do not start treatment with Femara if you are pregnant. When you are on this medication be sure about the use of effective birth control methods. Do not take more Femara than it was prescribed to you.

Femara is contraindicated in women who are pregnant. This medication may cause fetal harm when administered to a pregnant woman.

Side effects You may experience signs of allergic reaction such as hives, rash, difficulty breathing, facial swelling and also hot flashes, headache, night sweats, muscle or joint pain, fatigue, feeling weak, weight gain, nausea, swelling in the extremities. Stop taking the medication and contact your doctor if adverse reactions listed above get worse.

Drug interaction Concomitant use of Femara and tamoxifen by a daily dose of 20 mg leads to decrease of letrozole in blood concentrations. Caution should be exercised when letrozole is used together with drugs metabolized by cytochrome P450 isoenzymes (2A6 and 2S19). Inform your doctor about all medications, herbal products, food supplements and vitamins you use.

Missed dose If you missed a dose take it as soon as you remember. If it is almost time for your next dose just skip it and return to your regular schedule. Never take extra or double dose of Femara.

Overdose This medication is not likely to produce life-threating symptoms. Inform your doctor if you suspect that you took too much of this drug.

Storage Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.



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Marduk, Marduk

Marduk

Marduk , in Mesopotamian religion. the chief god of the city of Babylon and the national god of Babylonia ; as such, he was eventually called simply Bel, or Lord.

Originally, he seems to have been a god of thunderstorms. A poem, known as Enuma elish and dating from the reign of Nebuchadrezzar I (1119–1098 bce ), relates Marduk’s rise to such preeminence that he was the god of 50 names, each one that of a deity or of a divine attribute. After conquering the monster of primeval chaos, Tiamat. he became Lord of the Gods of Heaven and Earth. All nature, including humanity, owed its existence to him; the destiny of kingdoms and subjects was in his hands.

Marduk’s chief temples at Babylon were the Esagila and the Etemenanki, a ziggurat with a shrine of Marduk on the top. In the Esagila the poem Enuma elish was recited every year at the New Year festival. The goddess named most often as the consort of Marduk was Zarpanitu.

Marduk’s star was Jupiter. and his sacred animals were horses, dogs, and especially the so-called dragon with forked tongue, representations of which adorn his city’s walls. On the oldest monuments Marduk is represented holding a triangular spade or hoe, interpreted as an emblem of fertility and vegetation. He is also pictured walking or in his war chariot. Typically, his tunic is adorned with stars; in his hand is a sceptre, and he carries a bow, spear, net, or thunderbolt. Kings of Assyria and Persia also honoured Marduk and Zarpanitu in inscriptions and rebuilt many of their temples.

Marduk was later known as Bel, a name derived from the Semitic word baal . or “lord.” Bel had all the attributes of Marduk, and his status and cult were much the same. Bel, however, gradually came to be thought of as the god of order and destiny. In Greek writings references to Bel indicate this Babylonian deity and not the Syrian god of Palmyra of the same name.

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1990 - Morgan, intent on creating the most brutal and blasphemous metal act ever, forms Marduk

1991 - The ”Fuck Me Jesus” demo is released - Records but chooses not to release the 7” ”Here’s No Peace” - First live appearances, now considered cult shows

1992 - Debut album ”Dark Endless” recorded in June and released during the winter solstice - All through the year Marduk performs on various locations in Sweden, rapidly gaining a following and fan base

1993 - No Fashion rips the band off badly - Signs a record deal with French label Osmose Productions - Second full length album ”Those of the Unlight” released in October

1994 - The first Marduk gig abroad takes place – Black Metal Nights Festival in Oslo, Norway in April - Marduk’s first European tour, entitled ”Sons of Northern Darkness”, is carried out during May and June - Third full-length album ”Opus Nocturne” is recorded during autumn and surfaces on record shelves by the year’s end

1995 - “Winter War” – European headlining tour in February - ”Fuck Me Jesus” re-released as MCD in April - First time crossing the Atlantic – June show in Mexico City - A first visit to The Abyss studio, in order to re-mix ”Those of the Unlight”

1996 - Studio change – Marduk enters The Abyss to record ”Heaven Shall Burn… When We Are Gathered” in February - ”Heaven Shall Burn…” released in June - The (at the time) most extensive European tour launched in September - During the tour, ”Glorification” – a MCD with a remix from ”Heaven Shall Burn…” plus covers of songs by Bathory, Destruction and Piledriver, is released

1997 - Assailing Europe once more in the spring with the shorter ”Legion” tour - A live album, recorded on the 1996 ”Heaven Shall Burn…” tour, entitled ”Germania” is released - Primary support for legendary black metal act Mayhem on their re-union gig in East Germany - Swedish label Shadow Records releases ”Here’s No Peace” - During October and November Marduk immortalizes the much-anticipated successor to ”Heaven Shall Burn” – ”Nightwing”

1998 - ”Nightwing” hits the stores during spring - Appears on No Mercy Festival the week after the album release, to promote the new record - Autumn – spearheads the ”Black Metal Assault Tour” all through Europe

1999 - Enters the studio once again to record the perpetually pummeling ”Panzer Division Marduk” - Tours Scandinavia, Greece and Japan - Numerous summer festival appearances, such as Dynamo, with Marduk headlining the Black Stage - MCD ”Obedience” recorded - Another seven-week headlining tour during fall

2000 - ”Obedience” released on own label, Blooddawn Productions - Joins forces with Deicide and Cannibal Corpse for a shorter spring tour - Ends cooperation with Osmose Productions - Returns to Mexico for a two-week tour - Appears on most big summer festivals, among others Wacken Open Air, With Full Force and Waldrock - Ten-year anniversary show in hometown Norrkoping on Halloween - Releases the double-disc live album ”Infernal Eternal” the same night - Records seventh Marduk album, ”La Grande Danse Macabre”, in December

2001 - Visits the studio again for some miscellaneous recordings - ”La Grande Danse Macabre” released on March 5 - Headlines a 31-date European tour - US tour with Deicide - Headlines one of the Graspop Metal Meeting stages - Assembles and prepares the box-set ”Blackcrowned” - Shorter headlining tour, joining forces with heaviest acts in metal on the X-Mass Festivals through Europe

2002 - Forced to cancel headlining US tour due to visa issues - Box-set released in February - Fredrik discharged from the ranks - Emil Dragutinovic drafted as new drummer - Plays With Full Force festival in Germany and Tuska Open Air in Finland - Records Marduk’s eighth full-length album ”World Funeral” - Main support for Danzig in Europe - Co-headlines the annual X-Mass Festivals

2003 - “World Funeral” released in February and followed by a 31-date European headlining tour - August – headlines the Party San Open Air Festival in Germany - Morgan records material for a planned four-track Marduk EP entitled ”Portratt av Doda Barn” (“Portraits of Dead Children”), a recording that to this day remains unreleased - During October, Marduk embarks on a South American Tour, covering new ground such as Brazil, Argentina, Chile, Colombia, Costa Rica and a glorious return to Mexico - In December, vocalist Legion is out of the band

2004 - During January, Morgan records a three-track Marduk demo entitled “Todes Reich” with a drum machine as well as bass and vocals handled by himself - Vocalist Mortuus joins the band - The DVD “Funeral Marches and Warsongs” released in February - Headlines the Motala Metal Festival in Sweden in May – first Mortuus live appearance - Enters the local Endarker Studio for a pre-production of the upcoming album, known as the “Hastfer Session”. Marduk likes the atmosphere in the studio and decides to record the album there. - B. War is replaced on bass by returning long-time member Devo - Summer is spent recording the new album - Devo’s first live performance since returning is a headlining show at the Agglutination Festival in Southern Italy - September; listening session for selected journalists in Hamburg (Germany) and a special invite-only concert - New album, number nine, “Plague Angel” unleashed upon mankind in late November - Marduk headlines the annual X-Mass Festival package in Europe - Releases a special limited tour-EP entitled “Deathmarch”, also the name of the tour

2005 - Preparations to keep touring in support of the new album comes to a halt when drummer Emil breaks his arm in a fight - The band makes a triumphant appearance at the Wacken Open Air festival - The Deathmarch continues as Marduk is back on the road touring Europe during late August into September - October sees the band finally arriving in Turkey for three shows - The “Deathmarch Tour” prompts a return to South and Central America for selected shows in Mexico, Guatemala, El Salvador, Colombia, Argentina and Brazil - To celebrate 15 years of Marduk the band releases a limited edition live album “Warschau”, recorded in Poland earlier the same year

2006 - Marduk headlines the Metalboat ferry cruise between Sweden and Finland, as well as appearing at Norway’s Inferno Festival - “Imago Mortis” (“A picture of death”) – once again Marduk embarks on 20 dates of European violence - During the spring, the first four albums are re-issued - Marduk returns to Finland for the Nummi Rock Festival and also plays other festivals in Germany and Slovakia. Touring cycle of the year finalized at the Hellflame Festival in Osnabruck, Germany. - Massive two-disc DVD “Blood Puke Salvation” released on the October 6 - Preparations for recording the tenth studio album initiated

2007 - Enters studio during December 2006 to January 2007, replacing drummer Emil with Lars Broddesson in the process - February return to Mexico for three festival appearances - April sees the band touring Russia and Ukraine, date in Belarus cancelled by the Ministry of Culture - The same month, album number ten – “Rom 5:12”, is unleashed and subsequently hailed as Marduk’s paramount album to date by most of the media and fans alike. The Triumph of Death continues. - During summer the band makes selected festival appearances at Sweden Rock Festival, Metaltown and Waldrock Open Air - In August, Marduk set foot in the southern hemisphere for the first time in a march across Australia - September; a handful of Polish dates as warm-up for the upcoming European tour - November and December sees Marduk conducting a crushing 30-date European tour including shows in most Western European countries and for the first time, the Baltics

2008 - The “Vanitas Tour” of 2007 and 2008 rages on as the band during January hit the Balkans for an additional 20 dates. Finally, Marduk reaches countries such as Macedonia, Serbia, Romania and Bulgaria to spread the plague. - In early March, Marduk participates in Europe’s biggest indoor metal festival – Poland’s Metal Mania in Katowice - The same month, another return to the shores of South America for shows in Brazil, Chile, Colombia, Ecuador and Venezuela - Late April, the classic albums “Germania”, “Nightwing” and “Panzer Division Marduk” are reissued with bonus material and improved artwork; three albums that had been unavailable in most parts of the world for a long time - Summertime – Marduk marches across Europe and appears at the following festivals: Hellfest - France, Metalcamp – Slovenia, Kaltenbach – Austria, Allience Fest – Portugal and Summer Breeze – Germany - September sees the band returning to their loyal fans in Mexico for some selected shows - Yet another blow is delivered to Europe as Marduk in cohorts with Morbid Angel finish off 2008 with 22 dates during November and December

2009 - The band spends the early months preparing and finalizing the recording of studio album number eleven - March – the most northern show Marduk has done so far; Trettio Minus Festival in Lulea, Sweden - Once again, Marduk is prohibited from touring the US due to visa issues - Summertime appearances at the following festivals: Stonehell – Italy, Lorca Rock – Spain and Brutal Assault – Czech Republic. Marduk also headlines Party San Festival in Germany, where “Panzer Division Marduk” is performed in its entirety in order to celebrate its ten year anniversary. - Enters Endarker Studio to record the eleventh studio album, “Wormwood” - In August, the long awaited return to the US comes to fruition. Three selected East Coast dates, marking the band’s first visit in eight years. - “Blitzkrieg Tour” in late August and mid-September, 15 shows in Poland - September 24, “Wormwood” is let loose upon European soil, followed by its worldwide release during the beginning of October - “Funeral Nation” European tour. 30 shows from late September until the end of October, covering the western and southern parts of Europe. - November and December – Marduk returns to the shores of North America for a tour entitled “US Plague 2009”, 26 shows covering most of the States as well as the band’s first dates in Canada

2010 - “Funeral Nation Tour Part 2” starts off the year as Marduk tread across Europe focusing mainly on the Balkans as well as selected appearances in Germany, Austria, Benelux, Ireland and the UK – ending in February after 29 shows - April, a return to Northern Sweden at the House of Metal festival as well as headlining the Inferno Festival in Norway. The band also marches south, once again returning to the loyal legions of South America – burning through Brazil and Argentina. Directly followed by a blow to the East, the crusade continues in Belarus and Russia from late April into May. - May also sees the band in conspiracy with Deicide and Vader, a shorter tour under the moniker “Unholy Titans”. The package appears at the Metalfest Open Air Festivals in Switzerland, Germany, Austria, Hungary and Czech Republic as well as some club shows in France, Italy, Slovenia and Poland; a successful fortnight raid that comes to completion in the end of May. - July – festivals such as the Hellfest in France, With Full Force and Rockharz in Germany - In September, Marduk embarks on a three-week tour under the banner “The Great Northern War”, focusing on the northern parts of Europe and Scandinavia - As Marduk celebrates its 20 years anniversary they participate on the “Blackest of the Black” tour in the US; 25 dates with legendary acts as Danzig and Possessed - As 2010 runs towards its end, Marduk is the first black metal band to do a full Asian tour. The “Asian Black Death Redemption 2010” sees the band planting the banner of the wolf in China, Thailand, Singapore and Indonesia.

2011 - During the first month Marduk boards the 70 000 Tons of Metal cruise, a four day festival on the seas and largest floating festival ever. Two additional shows during the same trip, Miami in the USA and Cozumel, Mexico. - Already in the area, Marduk descends into Central America for shows in Honduras, Guatemala and Costa Rica - February – for the first time in many years, the Marduk Legion teams up with Mayhem and Nifleheim for a Swedish ceremony in Stromstad - March; three new anthems are recorded for an EP set for a spring release - Headlining show at Walpurgis Metal Days in Germany and Puntpop Festival in Belgium, as part of the spring equinox offensive - Late May – the three-track EP “Iron Dawn” is unleashed on the same day Marduk headlines Maryland Deathfest in USA. This marks the opening of the “7 Bowls Of Wrath Tour”, consisting of seven shows in seven cities in the US and Canada. The crusade comes to an end with a New York exhibition featuring highly acclaimed artist Oluremi White, displaying his works based on Marduk lyrics. - European summer festival schedule: Getaway Rock – Sweden, Summer Breeze – Germany, Motorcultor – France, Elsrock Festival in Holland, Mes Huff Festival in Switzerland and the last edition of Hole in the Sky – Norway - Marduk and Blooddawn Productions terminate its more than a decade long cooperation with Regain Records - Headlines Firebox Festival in Finland - Another northwards march – Sundsvall and Lulea in Sweden - Blooddawn Productions and Marduk sign a long-term deal with Century Media for worldwide collaboration - “Hatefest Tour”, three weeks of darkness over Europe, takes place during December as part of the “Herbstnebel Offensive” which after more than 220 shows finalizes the touring cycle for the “Wormwood” album - Endarker Studio is graced with a December visit, for the twelfth Marduk album

2012 - Dominum Maris Baltici – rulers of the Baltic Sea; Marduk performs on the Sweden Rock Cruise between Sweden and Finland - April; with the impending release of the new album, Marduk plays the first show in twelve years in their hometown of Norrkoping, Ostergotland. This ushers in the touring cycle for the coming anthem “Serpent Sermon”. - In cooperation with Sweden Rock Magazine, the limited edition “Souls for Belial” single is released - The music video for the song “Souls for Belial” is recorded by director Hakan Sjodin - The “Serpent Sermon World Tour” marches east, a two-week Russian tour in May – playing as far east as the capitol of Siberia on the border to Mongolia. Belarus date cancelled by the government, again. - “Serpent Sermon” unleashed upon mankind in late May - Coinciding with the album release, Marduk brings the “Serpent Sermon World Tour” to North America for a month’s worth of dates in Puerto Rico, USA, Canada and Mexico - Immediately upon the return to Europe, festival dates in Switzerland, Austria, Germany, Finland and Sweden - August sees the return to their loyal fans in Brazil for a row of dates - A massive 42-date European campaign in which the band plows through most of Eastern, Central and Western Europe is unleashed in August - During November, Marduk is presented with a gold reward for having sold over 10 000 copies of the “Souls for Belial” single in Sweden - Early December – Marduk headlines the Forlorn Festival in the north of Sweden, the hallmark of the end of a year riddled with conquest

2013 - The “Serpent Sermon World Tour” continues in early January with an assault in Australia and the first Marduk appearance in New Zealand - The following month Marduk returns for a month-long tour in the US and Canada, lasting into mid-March - Spring and early summer festival gigs: Thronefest – Belgium, Deathkult Open Air – Germany, Dokkum – Holland, Hellfest – France, Rockmarathon – Hungary, With Full Force – Germany, Hard Rock Lager – Estonia and Metaltown – Sweden - July and August – the war machine trudges through South America with shows in Mexico, Colombia, Peru, Chile and Brazil - Returns to Europe and the following festivals: Brutal Assault – Czech Republic, Agglutination Festival – Italy, Summer Breeze – Germany and Metal Mean – Belgium - September marks the end of Marduk’s 14 years absence from Japan, with seven crushing shows - “Serpent Sermon World Tour” is finalized with a slew of dates in Sweden during October. Since the release of “Serpent Sermon”, Marduk has now smothered the world with over 170 shows. - Drummer Lars forced into hiatus due to back/leg problems, F. Widigs fills in - November, headline show at Black Flames of Blasphemy Festival in Helsinki, Finland – a celebration of the “Those of the Unlight” album which was released 20 years ago, subsequently hailed as one of the most high-profile and iconic black metal album ever - Marduk ends the year with a storm of iron as the band tramples Europe on a 21-date tour, performing the entire “Panzer Division Marduk” album as well as “Those of the Unlight”. A worthy ending to yet another year under the banner of the wolf…

2014 - Another year of subjugation primed as Marduk performs at Blastfest in Bergen, Norway

To be continued…



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Commonly reported side effects of metformin include: lactic acidosis, vomiting, nausea and vomiting, diarrhea, nausea, and flatulence. Other side effects include: diarrhea, nausea, vomiting, decreased vitamin b12 serum concentrate, and weakness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to metformin: oral solution, oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by metformin. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking metformin:

More common:

Abdominal or stomach discomfort

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diarrhea

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fever or chills

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painful or difficult urination

sleepiness

Less common:

Anxiety

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chest discomfort

cold sweats

coma

confusion

cool, pale skin

depression

difficult or labored breathing

dizziness

fast, irregular, pounding, or racing heartbeat or pulse

feeling of warmth

headache

increased hunger

increased sweating

nausea

nervousness

nightmares

redness of the face, neck, arms, and occasionally, upper chest

seizures

shakiness

shortness of breath

slurred speech

tightness in the chest

unusual tiredness or weakness

wheezing

Rare

Behavior change similar to being drunk

difficulty with concentrating

drowsiness

lack or loss of strength

restless sleep

unusual sleepiness

Minor Side Effects

Some of the side effects that can occur with metformin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

Acid or sour stomach

belching

bloated

excess air or gas in the stomach or intestines

full feeling

heartburn

indigestion

loss of appetite

metallic taste in the mouth

passing of gas

stomachache

stomach upset or pain

vomiting

weight loss

Less common:

Abnormal stools

bad, unusual, or unpleasant (after) taste

change in taste

difficulty with moving

discoloration of the fingernails or toenails

flu-like symptoms

joint pain

rash

runny nose

sneezing

stuffy nose

swollen joints

For Healthcare Professionals

Applies to metformin: compounding powder, oral solution, oral tablet, oral tablet extended release

General

Gastrointestinal events such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite have been frequently reported during therapy initiation and resolve spontaneously in most cases.

Adverse events in the pediatric population appear to be similar in nature and severity to that published in adults. [Ref ]

Metabolic

Common (1% to 10%): Hypoglycemia Very rare (less than 0.01%): Lactic acidosis [Ref ]

Gastrointestinal

Very common (10% or more): Diarrhea (53.2%), nausea/vomiting (25.5%), flatulence (12.1%) Common (1% to 10%): Indigestion, abdominal discomfort, abnormal stools, dyspepsia, loss of appetite [Ref ]

Hematologic

Very rare (less than 0.01%): Subnormal vitamin B12 levels [Ref ]

Other

Common (1% to 10%): Asthenia, chills, flu syndrome, accidental injury [Ref ]

Hepatic

Very rare (less than 0.01%): Liver function test abnormalities, hepatitis [Ref ]

Cardiovascular

Common (1% to 10%): Chest discomfort, flushing, palpitation [Ref ]

Dermatologic

Common (1% to 10%): Rash, nail disorder, increased sweating Very rare (less than 0.01%): Erythema, pruritus, urticaria [Ref ]

Endocrine

Frequency not reported: Reduction in thyrotropin (TSH) levels [Ref ]

Immunologic

Very common (10% or more): Infection (20.5%) [Ref ]

Musculoskeletal

Common (1% to 10%): Myalgia [Ref ]

Nervous system

Common (1% to 10%): Lightheadedness, taste disturbances [Ref ]

Psychiatric

Common (1% to 10%): Headache [Ref ]

Respiratory

Common (1% to 10%): Rhinitis [Ref ]

References

1. "Product Information. Glucophage (metformin)." Bristol-Myers Squibb, Princeton, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Fortamet (metFORMIN)." Physicians Total Care, Tulsa, OK.

4. Cerner Multum, Inc. "Australian Product Information." O 0

5. "Product Information. Riomet (metFORMIN)." Ranbaxy Pharmaceuticals, Jacksonville, FL.

6. "Product Information. Glumetza (metFORMIN)." Biovail Pharmaceuticals Canada, Mississauga, IA.

Not all side effects for metformin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .

More about metformin

Consumer resources

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill. knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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Densical Version Version By Pf-Soft - How To Uninstall It, Densical

Advanced Uninstaller PRO

DensiCal version 0.15

A guide to uninstall DensiCal version 0.15 from your PC

You can find below detailed information on how to uninstall DensiCal version 0.15 for Windows. It is made by PF-Soft. Further information on PF-Soft can be found here. More information about the software DensiCal version 0.15 can be found at http://www. metgen. org. The application is frequently installed in the C:Program FilesDensiCal directory (same installation drive as Windows). "C:Program FilesDensiCalunins000.exe" is the full command line if you want to remove DensiCal version 0.15. DensiCal version 0.15's main file takes about 1.79 MB (1881600 bytes) and its name is DensiCal. exe.

The executable files below are part of DensiCal version 0.15. They occupy about 2.48 MB ( 2596126 bytes) on disk.

DensiCal. exe (1.79 MB)

unins000.exe (697.78 KB)

The information on this page is only about version 0.15 of DensiCal version 0.15.

A way to remove DensiCal version 0.15 from your computer with Advanced Uninstaller PRO

DensiCal version 0.15 is an application by the software company PF-Soft. Frequently, users want to remove this application. This is easier said than done because deleting this by hand requires some know-how regarding removing Windows programs manually. One of the best SIMPLE procedure to remove DensiCal version 0.15 is to use Advanced Uninstaller PRO. Here are some detailed instructions about how to do this:

1. If you don't have Advanced Uninstaller PRO already installed on your PC, install it. This is good because Advanced Uninstaller PRO is an efficient uninstaller and all around utility to optimize your computer.

go to http://www. advanceduninstaller. com/download/

download the setup by clicking on the green DOWNLOAD NOW button

install Advanced Uninstaller PRO

2. Run Advanced Uninstaller PRO. It's recommended to take your time to admire Advanced Uninstaller PRO's design and wealth of tools available. Advanced Uninstaller PRO is a powerful system optimizer.

5. A list of the programs existing on your PC will be made available to you

6. Scroll the list of programs until you find DensiCal version 0.15 or simply click the Search field and type in "DensiCal version 0.15". If it is installed on your PC the DensiCal version 0.15 app will be found automatically. Notice that when you select DensiCal version 0.15 in the list of programs, the following data regarding the program is available to you:

Star rating (in the left lower corner). The star rating tells you the opinion other people have regarding DensiCal version 0.15, ranging from "Highly recommended" to "Very dangerous".

Reviews by other people - Press the Read reviews button.

Technical information regarding the program you are about to uninstall, by clicking on the Properties button.

For instance you can see that for DensiCal version 0.15:

The web site of the program is: http://www. metgen. org

The uninstall string is: "C:Program FilesDensiCalunins000.exe"

7. Click the Uninstall button. A window asking you to confirm will appear. Confirm the uninstall by pressing the Uninstall button. Advanced Uninstaller PRO will automatically uninstall DensiCal version 0.15.

8. After uninstalling DensiCal version 0.15, Advanced Uninstaller PRO will offer to run a cleanup. Click Next to perform the cleanup. All the items that belong DensiCal version 0.15 which have been left behind will be detected and you will be able to delete them. By removing DensiCal version 0.15 with Advanced Uninstaller PRO, you can be sure that no Windows registry items, files or directories are left behind on your PC.

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About Us - Emox Engineering, Emox

About Us

Since 2008, Emox Engg has been committed to sourcing new technology products and providing highest quality solutions to oil, gas, water and waste water industry in Qatar and drive long term business value creation. Initially the company was established as a technical services company to meet growing needs of electrical and instrumentation services in water industry in Qatar

Our single-minded focus on product quality and service excellence has helped us reap the appreciation of both local industries and the principals.

Emox Enjoys continued growth and stature in the ever increasing competitive industry. Our clients in Qatar are provided with additional specialized engineering support from our local team to supplement and enhance the links with our suppliers.

Emox Engg is an authorized value providers of ABB and provide Low voltage drive solutions to various customers in state of Qatar. Our solutions include technical project consultancy, engineering of drive and instrumentation solution, and field installation and commissioning services.

A Reliable supplier to oil, gas, water & waste water Industries:

Provide consultancy role to the end user on Drives, measurement & control techniques

Applications, Engineering, Sales, service and spare parts support to the end users

Our Goal is to bring new solutions, performance, productivity and profits to our customers.

From the process unit, To the control room, To the board room.

We are closely associated with well-known local & international consultants, inspection Agencies, service providers, clients and contractors.

Emox’s value addition is to work with the client from the conceptual stage of the project with design development and specify principals product features in the specification.

Our success has been the result of addressing key customer requirements and passing on vital information to our principals.

We are proud to be associated with major landmark projects of Kahramaa like Al Wukair pumps station & tanker filling station, Underground reservoir, Mega reservoir projects, DMA & SCADA integration project to name a few…

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Mission, Vision & Value

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Dibertil, Dibertil

Gastrointestinal - Dibertil (Brand name: metoclopramide)

Metoclopramide is used for short term treatment of gastroesophageal reflux disease (GERD) in certain patients who do not respond to other therapy. It is used to treat symptoms of a certain digestive problem in diabetic patients (diabetic gastroparesis). Metoclopramide is a gastrointestinal stimulant and antinauseant. It works by increasing the movement of the stomach and intestines to help move food and acid out of the stomach more quickly. It also works in certain areas in the brain to decrease nausea.

Use Metoclopramide as directed by your doctor.

Take Metoclopramide by mouth 30 minutes before meals unless directed otherwise by your doctor.

It may take several days to weeks for Metoclopramide to work. Do not stop taking Metoclopramide without checking with your doctor.

If you miss a dose of Metoclopramide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Metoclopramide.

Store Metoclopramide at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Metoclopramide out of the reach of children and away from pets.

Do NOT use Metoclopramide if:

you are allergic to any ingredient in Metoclopramide

you have seizures (eg, epilepsy); bleeding, blockage, or perforation in your stomach or intestines; or tumors on your adrenal gland (pheochromocytoma)

you are taking cabergoline or pergolide

you are taking medicines, such as phenothiazines (eg, chlorpromazine), that may cause extrapyramidal reactions (abnormal, involuntary muscle movements of the head, neck, or limbs). Check with your doctor if you are unsure if any of your medicines may cause extrapyramidal reactions.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Metoclopramide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of mental or mood problems (eg, depression) or suicidal thoughts or actions

if you have a history of asthma, heart failure, high blood pressure, diabetes, Parkinson disease, blood problems (eg, porphyria), kidney problems, liver problems (eg, cirrhosis), breast cancer, or low levels of an enzyme called methemoglobin reductase

if you are taking another form of Dibertil (eg, syrup, orally disintegrating tablet).

Some medicines may interact with Metoclopramide. Tell your health care provider if you are taking any other medicines, especially any of the following:

Monoamine oxidase inhibitors (MAOIs) (eg, phenelzine) because the risk of serious side effects (eg, high blood pressure, seizures) may be increased

Anticholinergic medicine (eg, hyoscyamine) or narcotic pain medicines (eg, codeine) because they may decrease Metoclopramide's effectiveness

Acetaminophen, benzodiazepines (eg, diazepam), cyclosporine, insulin, levodopa, phenothiazines (eg, chlorpromazine), sedatives (eg, zolpidem), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), succinylcholine, or tetracycline because the risk of their side effects may be increased by Metoclopramide

Cabergoline, digoxin, or pergolide because their effectiveness may be decreased by Metoclopramide.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Metoclopramide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Metoclopramide may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Metoclopramide with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Metoclopramide without first checking with your doctor; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Do NOT take more than the recommended dose or use Metoclopramide for longer than 12 weeks without checking with your doctor.

Diabetes patients - Metoclopramide may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Tell your doctor or dentist that you take Metoclopramide before you receive any medical or dental care, emergency care, or surgery.

Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Metoclopramide. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.

Some patients who take Metoclopramide may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Metoclopramide in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Metoclopramide.

Patients who take Metoclopramide may be at increased risk for new or worsening mental or mood changes (eg, depression) or suicidal thoughts or actions. Watch patients who take Metoclopramide closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Metoclopramide may increase the amount of a certain hormone (prolactin) in your blood. Symptoms may include enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge. Contact your doctor right away if you experience any of these symptoms.

Lab tests, including liver and kidney function tests, may be performed while you use Metoclopramide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Metoclopramide with caution in the elderly; they may be more sensitive to its effects, especially drowsiness, confusion, and uncontrolled muscle movements, including tardive dyskinesia.

Metoclopramide should be used with extreme caution in children; safety and effectiveness in children have not been confirmed. The risk of developing uncontrolled muscle movements may be greater in children.

Pregnancy and breast feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Metoclopramide while you are pregnant. Metoclopramide is found in breast milk. If you are or will be breast-feeding while you use Metoclopramide, check with your doctor. Discuss any possible risks to your baby.

A small number of patients have experienced withdrawal symptoms when stopping Metoclopramide. These symptoms may include dizziness, nervousness, and headache.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Decreased energy; diarrhea; dizziness; drowsiness; headache; nausea; restlessness; tiredness; trouble sleeping.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); abnormal thinking; confusion; dark urine; decreased balance or coordination; decreased sexual ability; fast, slow, or irregular heartbeat; fever; hallucinations; loss of bladder control; mental or mood changes (eg, depression, anxiety, agitation, jitteriness); seizures; severe or persistent dizziness, headache, or trouble sleeping; severe or persistent restlessness, including inability to sit still; shortness of breath; stiff or rigid muscles; sudden increased sweating; sudden, unusual weight gain; suicidal thoughts or actions; swelling of the arms, legs, or feet; uncontrolled muscle spasms or movements (eg, of the arms, legs, tongue, jaw, cheeks; twitching; tremors); vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Tetramex Spray - Fda Prescribing Information, Side Effects And Uses, Tetramax

Tetramex Spray

Warnings

For external use only. Use only as directed. Avoid contact with eyes and mucous membranes. Do not apply to open wounds or damaged skin. Do not use in combination with any external heat source. Do not use on irritated or broken skin, or use in combination with any bandage, wrap, stocking or similar device or garment. Consult physician for children under 12 years of age. Do not use if allergic to Camphor, Histamine, Menthol or any other components. Stop use and consult physician if symptoms worsen or persist for more than 7 days. Stop use if itching or excessive skin irritation occurs. If pregnant or breast feeding, contact physician prior to use.

ACTIVE INGREDIENTS: Camphor 3% Menthol 1% Tetracaine HCL 2% INDICATIONS AND USAGE: For temporary relief of minor aches and pains of the muscles and joints associated with simple backache, arthritis, strains, bruises and sprains. CLINICAL PHARMACOLOGY: Camphor is used topically to increase local blood flow and as a “counterirritant.” When applied externally, camphor numbs the nerve ending. The nerve endings then no longer transmit the sensation of pain. Menthol instantly brings cool, soothing pain relief to aching muscles. Menthol also has a natural analgesic attribute when applied topically. It has molecules called ligands, which attach themselves to receptors (Kappa Opioid Receptors) in your cell, which produces a numbing effect. Using Menthol topically causes vasodilation, which increases blood flow to the affected area, allowing other medicinal ingredients found in the topical spray to work faster. When applied externally, camphor numbs the nerve ending. The nerve endings then no longer transmit the sensation of pain. Tetracaine is a local anesthetic (numbing medicine). It works by blocking nerve signals in your body. It does this by stopping the sodium entering the nerve ending at the site of the pain. This prevents an electrical signal building up and passing along the nerve fibers to the brain. CONTRAINDICATIONS: Tetramex is contraindicated in patients with known history of hypersensitivity to local anesthetics, Menthol, camphor, and to other components of Tetramex topical spray. Directions: Adults and children 12 years and over apply directly to affected area. Do not use more than four times per day. Children under 12 years of age, consult a physician prior to use. Wash hands with soap before and after use. Avoid contact with eyes and mucous membranes. WARNING: - For external use only. Use only as directed. - Avoid contact with eyes and mucous membranes. - Do not apply to open wounds or damaged skin. - Do not use in combination with any external heat source. - Do not use on irritated or broken skin, or use in combination with any bandage, wrap, stocking or similar device or garment. - KEEP OUT OF REACH OF CHILDREN. Consult physician for children under 12 years of age. - Do not use if allergic to Menthol, Lidocaine, or any other components. - Stop use and consult physician if symptoms worsen or persist for more than 7 days. - Stop use if itching or excessive skin irritation occurs. - If pregnant or breast feeding, contact physician prior to use. Other Ingredients: Aqua (Deionized Water), Arnica Montana Flower Extract, Boswellia serrata extract, Dimethyl Sulfone, Emu Oil, Ethoxydiglycol, Glucosamine HCL, Glycrrhiza glabra (Licorice) Root Extract, PEG-40, Hydrogenated Castor Oil, Propylene Glycol (and) Diazolidinyl Urea (and) Iodopropynyl Butylcarbamate, SD Alcohol 40B. How Supplied: Mentholix is supplied in a 4 ounce (120ml) plastic bottle with a fine mist sprayer for topical application. Storage: Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Avoid direct sunlight.

Aqua (Deionized Water), Arnica Montana Flower Extract, Boswellia Serrata Extract, Dimethyl Sulfone, Emu Oil, Ethoxydiglycol, Glucosamine HCL, Glycrrhiza glabra (Licorice) Root Extract, PEG-40 Hydrogenated Castor Oil, Propylene Glycol (and) Diazolidinyl Urea (and) Lodopropynyl Butylcarbamate, SD Alcohol 40B, Fragrance.

Apply directly to affected area. Do not use more than four times per day. Children under 12 years of age: Consult a Physician.

Camphor. 3.0% Menthol USP. 1.0% Tetracaine HCL. 2.0%

KEEP THIS AND ALL MEDICATIONS OUT OF REACH OF CHILDREN

For temporary relief of minor aches and pains of the muscles and joints associated with simple backache, arthritis, strains, bruises and sprains.

Store in 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]



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The Flower Panter, At Sai One @, Baycip

The Flower Panter, at Sai One

I got the idea for this flower panter, a Denim Garden if you will, whilst walking down the streets a few days ago. I never have time to do anything whimsy, but a three day weekend and a two day work furlough was the perfect opportunity to get ‘r done. My good friend Angel has a fashion boutique on 818 Elmwood Ave in Buffalo, NY, and I’m always helping him with creative ways to pull people into his store. If the idiots after dark don’t destroy it in a week, I’m prolly going to make a few more, have a little denim garden in front of Sai One (and Splash Panic. Angel’s hipster fashion boutique neighbors).

Jump through to see more pics and how I did it.

Pair of grungy jeans, nothing hipster skinny, and nothing super long.

2′x2′ square of plywood… any hardware store like Home Depot will have these in the project wood section

4 L Brackets

3/4″ PVC Pipe… hardware stores sell by the 10′ or so. Have them cut you two pieces the length of the inseam of the pants plus 5″ so you won’t have any trouble fitting the pipe in the back of your chevelle.

2 3/4″ PVC Elbows

PVC Primer and Cement… You need the purple primer stuff and the cement to make sure your pipe stays together. I suppose this part is optional, but its your fault if it falls apart during assembly.

Duct tape

2-3 wire coat hangers, or 10ft of heavy armature wire.

1 Tarp, I found a cheap 6′x8′ blue one for about 6 bucks.

strong needle, and strong thread.

Sewing Skills..

Staple gun

2 cubic feet of potting soil (one large or two small bags)

1 cubic foot of pea gravel (1 smallish bag)

Using your jeans as a guide, make a pattern on the tarp to create a lining to fit inside your jeans. Denim is porous, and will seep to all hell if you don’t have a lining. I had Angel do this part and he took a coat hanger and sewed the lining over the hooped coat hanger.

Stand your jeans up on the board, figure out the most natural stance and mark where the pants stand on the board. Drill holes on the pipe and attach the L brackets, and secure them on the board with screws. Make sure the brackets are installed like in the photos (front and back) or you’re going to have a hard time stabilizing the planter. While optional, I lashed the pipe to the bracket with duct tape to make sure they weren’t going anywhere.

Measure the distance between the two pipes and cut a section of PVC about an inch or so short. Cement the PVC to the elbows and make sure the elbows point in the same direction as each other. Fit the liner and jeans over the two pipes, and then secure the elbowed section on top. I didn’t cement this section because it wasn’t that important, and I thought might need to take the jeans off if something went wrong.

Using needle and thread, and the coat hangers/armature wires secure the jeans to the pipe. make sure you hook a bit of wire at the crotch and secure it to the pipe. the legs wille stand on their own, but you need to make sure that the waist of the jeans won’t sag or droop off. Use a staple gun to tack the tarp lining to the board, and adjust the jeans to cover it all.

Haul the pants planter to where you want it to live and split the pea gravel between the two legs. This will give the whole thing a strong base. Fill the rest up with potting soil, tamp it down, and add some more till you’ve reached the top.

Plant your flowers, bury the board in mulch or whatever and enjoy your new denim garden!

The whole planter felt very sturdy, and and the liner will prevent seepage when you water your plants.

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More updates.

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Tony Provin Professor and Soil Chemist Email: t-provin@tamu. edu Phone: 979-845-4816 Office: 108 Soil Testing Laboratory Education: Ph. D. Purdue University, 1996. Resume/CV http://soiltesting. tamu. edu

Specialty :Soil Chemistry

My Extension and research program focuses on testing methodologies for the evaluation of water, plant and soils as related to agronomic and environmental considerations. Additionally, the program focuses on the collection of samples prior to analyses and the development of fertilizer, amendments or other cultural practice recommendations to improve both economic and environmental productivity of the landscape. The center piece of my program revolves around the Soil, Water and Forage Testing Laboratory, the outreach Extension components of nutrient management and water quality, and utilization of advanced instrumentation for analytical analyses of agricultural samples.

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Tony Provin Professor and Soil Chemist Email: t-provin@tamu. edu Phone: 979-845-4816 Office: 108 Soil Testing Laboratory Education: Ph. D. Purdue University, 1996. Resume/CV http://soiltesting. tamu. edu

Specialty :Soil Chemistry

My Extension and research program focuses on testing methodologies for the evaluation of water, plant and soils as related to agronomic and environmental considerations. Additionally, the program focuses on the collection of samples prior to analyses and the development of fertilizer, amendments or other cultural practice recommendations to improve both economic and environmental productivity of the landscape. The center piece of my program revolves around the Soil, Water and Forage Testing Laboratory, the outreach Extension components of nutrient management and water quality, and utilization of advanced instrumentation for analytical analyses of agricultural samples.

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Merial Acquires Two Major Equine Health Products From Bayer, Hyonate

Merial Aquires LEGEND® and MARQUIS®

Merial acquires two major equine health products from Bayer - Acquisition broadens Merial's global equine health solutions

Paris, France – December 17, 2014 – Sanofi today announced that Merial, its animal health company, has reached an agreement with Bayer HealthCare to purchase two Bayer equine health products, LEGEND ® /HYONATE ® ( hyaluronate sodium ) and MARQUIS ® ( ponazuril ).

LEGEND/HYONATE is an injectable solution that treats noninfectious joint dysfunction in horses; and MARQUIS Antiprotozoal Oral Paste is the first FDA-approved treatment for equine protozoal myeloencephalitis (EPM), a disease that affects the central nervous system in horses.

We are pleased to add two top equine products to our global portfolio. LEGEND and MARQUIS are highly regarded by the horse community and further support our commitment to equine veterinarians, horse owners and trainers. This addition is one example of our strategy to invest in business opportunities that enable us to deliver innovative solutions to veterinarians across animal species.

Merial CEO and Sanofi EVP Carsten Hellmann

The purchase, expected to be finalized in early 2015, further broadens Merial's portfolio of leading products that improve the health and performance of horses. LEGEND/HYONATE is primarily sold in the US and Canada, but is available in more than 40 countries with the UK and Japan as important markets. MARQUIS is only sold in the US and Canada. Merial plans to make both products available to veterinarians in countries around the world. The acquisition is subject to customary closing conditions.

Merial is a global leader in advancing the health of pets, horses and production animals. The company's global equine portfolio currently includes products to treat and prevent Equine Gastric Ulcer Syndrome and to control parasites in horses, as well as vaccines to help prevent Equine West Nile Virus, Potomac Horse Fever, equine influenza, and rabies in horses. In October 2014, Merial launched its latest equine addition, with the EU approval of the updated equine influenza vaccine PROTEQFLU ® .

About Merial

Merial is a world-leading, innovation-driven animal health company, providing a comprehensive range of products to enhance the health, well-being and performance of a wide range of animals. Merial employs around 6,200 people and operates in more than 150 countries worldwide with more than to €2 billion of sales. Merial is a Sanofi company merial. com .

About Sanofi

Sanofi, a global healthcare leader, discovers, develops and distributes therapeutic solutions focused on patients' needs. Sanofi has core strengths in the field of healthcare with seven growth platforms: diabetes solutions, human vaccines, innovative drugs, consumer healthcare, emerging markets, animal health and the new Genzyme. Sanofi is listed in Paris (EURONEXT: SAN ) and in New York (NYSE: SNY ).

Sanofi Forward-Looking Statements

This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. These statements include projections and estimates and their underlying assumptions, statements regarding plans, objectives, intentions and expectations with respect to future financial results, events, operations, services, product development and potential, and statements regarding future performance. Forward-looking statements are generally identified by the words "expects", "anticipates", "believes", "intends", "estimates", "plans" and similar expressions. Although Sanofi's management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Sanofi, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, the uncertainties inherent in research and development, future clinical data and analysis, including post marketing, decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug, device or biological application that may be filed for any such product candidates as well as their decisions regarding labelling and other matters that could affect the availability or commercial potential of such product candidates, the absence of guarantee that the product candidates if approved will be commercially successful, the future approval and commercial success of therapeutic alternatives, the Group's ability to benefit from external growth opportunities, trends in exchange rates and prevailing interest rates, the impact of cost containment policies and subsequent changes thereto, the average number of shares outstanding as well as those discussed or identified in the public filings with the SEC and the AMF made by Sanofi, including those listed under "Risk Factors" and "Cautionary Statement Regarding Forward-Looking Statements" in Sanofi's annual report on Form 20-F for the year ended December 31, 2013. Other than as required by applicable law, Sanofi does not undertake any obligation to update or revise any forward-looking information or statements.

For further information, please contact:

Sanofi Media Relations



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Cyklofosfamid - Antineoplastic Agents, Antirheumatic Agents, Immunosuppressive Agents, Atc L01aa01,

Cyklofosfamid

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Cyklofosfamid Indication

For management of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma and carcinoma of the breast

Cyklofosfamid Pharmacology

Cyclophosphamide is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Cyklofosfamid Absorption

Cyklofosfamid side effects and Toxicity

infection, myelosuppression, and cardiac toxicity

Cyklofosfamid Patient Information

This medicine is a type of chemotherapy for treating cancers of the blood and certain other cancers. This medicine interferes with the way cancer cells grow. Take your doses on a regular scheduled time and DO NOT take this medicine more often than directed by your health care provider. Finish the full course prescribed by your health care provider. DO NOT stop taking this medicine unless diredted to do so by your health care provider. While taking this medicine, you make get infection more easily. Call your doctor if you get a fever, chills, or sore throat. Drink plenty of water with this medicine.

Cyklofosfamid Organisms Affected

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Benzhexol

Richard Jewell

University of Southampton School of Medicine, Southampton, United Kingdom

Available online 8 January 2008.

Benzhexol, also known as trihexyphenidyl, hydrochloride is a tertiary amine antimuscarinic drug with actions similar to atropine. It also has direct antispasmodic action on smooth muscle. Despite having been shown to adversely affect memory …

Name of the Clinical Form

Benzhexol Hydrochloride; Trihexiphenidyl Hydrochloride

Related Names Source: EMTREE

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XIPEN

FORMA FARMACEUTICA Y FORMULACION :

Cada gragea de liberacion prolongada contiene:

Pentoxifilina. 400 mg Excipiente c. b.p. 1 gragea

INDICACIONES TERAPEUTICAS : Es aceptada la utilizacion de la pentoxifilina en el tratamiento de alteraciones vasculares perifericas, aliviando la sintomatologia de la claudicacion intermitente, incluyendo a las ulceras troficas. Otra de sus indicaciones es la insuficiencia vascular cerebral, disminuyendo con esto sus manifestaciones clinicas como la perdida de la memoria, alteraciones en la concentracion. Se indica tambien en el tratamiento de alteraciones circulatorias en ojo y oido cuando estas se asocian a procesos degenerativos.

La pentoxifilina tiene otros usos que aun no son aceptados como en los protocolos de tratamiento de pacientes con ulceras ocasionadas por extasis con insuficiencia venosa, este tratamiento se realiza en conjunto con otros farmacos. Sin embargo, se requieren mas estudios para determinar la eficacia de la medicacion propuesta.

FARMACOCINETICA Y FARMACODINAMIA EN HUMANOS : La pentoxifilina es casi absorbida en su totalidad cuando se administra por via oral, su absorcion es lenta, pero no se altera por los alimentos, su pico plasmatico ocurre a las 12 horas, es transportada unida a la membrana de los eritrocitos, su biotransformacion ocurre primero a nivel de eritrocito y despues a nivel hepatico, algunos de sus metabolitos son activos. La vida media del farmaco antes de su biotransformacion es entre 0.4 a 0.8 horas y la de sus metabolitos es de 1 a 1.6 horas. Debido a su corta vida media, el farmaco no llega a acumularse. La eliminacion de los metabolitos es por la via renal, por lo que los pacientes que tienen la funcion renal alterada, pueden retrasar la eliminacion; la eliminacion del farmaco por via fecal es minima, tan solo 4%.

La pentoxifilina actua reduciendo la viscosidad sanguinea, mejorando la flexibilidad de los eritrocitos, el flujo microcirculatorio y las concentraciones de oxigeno en los tejidos. Mejorando la flexibilidad de los eritrocitos, parece que se inhibe la fosfodiesterasa. dando como resultado un aumento del AMP ciclico de las celulas sanguineas de la serie roja.

La disminucion de la viscosidad sanguinea origina una reduccion en las concentraciones de fibrinogeno y una inhibicion de la agregacion plaquetaria.

CONTRAINDICACIONES : La pentoxifilina esta contraindicada en pacientes con historia de hipersensibilidad al farmaco o a otras xantinas; no debera emplearse en pacientes con infarto del miocardio, en pacientes con insuficiencia coronaria o que tienen arritmias cardiacas. Esta contraindicado su empleo en pacientes que presentan hemorragias graves, hemorragias retinianas, sangrados activos y en pacientes que presentan insuficiencia hepatica o renal.

PRECAUCIONES GENERALES : Ingerir el medicamento entero sin romperse, masticarse o triturarse. Los efectos secundarios o de intoxicacion pueden ser mas severos en los ancianos. El medicamento debera mantenerse lejos del alcance de los ninos.

PRECAUCIONES O RESTRICCIONES DE USO DURANTE EL EMBARAZO OLA LACTANCIA : No existen estudios completos en humanos en cuanto a la posibilidad de dano a los productos de mujeres embarazadas que ingirieron pentoxifilina. solo se reportan alteraciones causadas por el uso del farmaco en animales de experimentacion, no obstante no se recomienda su uso en mujeres embarazadas.

En estudios en humanos se ha comprobado que la pentoxifilina se excreta por la leche materna, sin embargo, no se han determinado alteraciones en los ninos de madres que ingirieron el farmaco; en estudios hechos en animales de experimentacion se ha podido determinar que el farmaco produce fibroadenomas mamarios, por lo anterior no debera administrarse a mujeres que estan lactando.

REACCIONES SECUNDARIAS Y ADVERSAS : Las reacciones secundarias mas frecuentemente encontradas despues del uso de la pentoxifilina son mareos, dolor de cabeza, nauseas, vomitos y malestar abdominal. Menos frecuentes son dolor en el pecho, frecuencia cardiaca irregular, se reporta la existencia de comezon cutanea, urticaria y edema angioneuritico aun cuando son muy raras pero puede llegar a presentarse incluso anafilaxia. Existe sintomatologia secundaria al uso de la pentoxifilina que debe orientar hacia una sobredosis de medicamentos y estos son: somnolencia, bochorno, desfallecimiento, vomitos de color cafe, arreflexia e incluso convulsiones tonicoclonicas.

INTERACCIONES MEDICAMENTOSAS Y DE OTRO GENERO : La pentoxifilina debera emplearse con cautela cuando se requiera el uso conjunto de otros anticoagulantes como cumarinicos o heparina; de igual forma debera emplearse con cautela cuando se administren otros farmacos que alteran la coagulacion sanguinea ocasionando alteraciones de hipoprotrombinemia como las cefalosporinas o el acido valproico. de igual forma se debera tener cuidado de su empleo cuando se requiere la utilizacion de otros farmacos que alteren la agregacion plaquetaria.

Los efectos de los farmacos antihipertensivos pueden ser potencializados al utilizarse conjuntamente con la pentoxifilina por lo que puede ser necesario ajustar la dosis de estos medicamentos.

La cimetidina aumenta significativamente la permanencia de la pentoxifilina en el plasma, por lo que se incrementa la posibilidad de ver sus efectos durante la concurrencia del uso de ambos farmacos.

El uso del tabaco puede interferir con sus efectos terapeuticos, ya que, la nicotina constrine los vasos sanguineos, por lo que no se recomienda fumar mientras se administre el farmaco.

Al utilizar la pentoxifilina conjuntamente con otros derivados xantinicos puede presentarse una estimulacion excesiva del sistema nervioso central.

ALTERACIONES DE PRUEBAS DE LABORATORIO : Existe el reporte, aunque en incidencia muy rara, de que puede presentarse trombocitopenia con el uso de la pentoxifilina.

PRECAUCIONES Y RELACION CON EFECTOS DE CARCINOGENESIS, MUTAGENESIS, TERATOGENESIS Y SOBRE LA FERTILIDAD : En estudios realizados con altas dosis y por periodos prolongados de pentoxifilina. no se han determinado alteraciones carcinogeneticas. ni mutageneticas. No existen reportes de alteraciones en la reproduccion en humanos por el uso de la pentoxifilina.

DOSIS Y VIA DE ADMINISTRACION : Oral.

La dosis usualmente recomendada es de 400 mg 3 veces al dia, si se reporta sintomatologia que haga sospechar la presencia de sobredosis se puede utilizar dos veces al dia, dicha dosis tambien es recomendada en el tratamiento del paciente anciano, ya que este tipo de pacientes son mas susceptibles al medicamento. Se recomienda extender el tratamiento por ocho semanas, y existen reportes de que se han tenido buenos resultados cuando el tratamiento se extiende hasta por seis meses

SOBREDOSIFICACION O INGESTA ACCIDENTAL: MANIFESTACIONES Y MANEJO (ANTIDOTOS) : Cuando existe ingesta accidental o intencional de grandes dosis del medicamento, es necesario trasladar al paciente a una unidad hospitalaria, debera realizarse de forma inmediata lavado gastrico con la finalidad de extraer la mayor cantidad del medicamento ingerido; debera proporcionarse al paciente medidas de sosten como soporte respiratorio y mantener la presion sanguinea, si se requiere utilizar expansores del plasma y cuando existan convulsiones controlarlas para lo cual se recomienda el uso de diazepam a las dosis requeridas por el paciente. La intoxicacion puede presentarse no en forma aguda por lo cual debera advertirse al paciente de los sintomas de intoxicacion que inicialmente pueden ser nauseas, mareos, taquicardia, hipotension arterial, pudiendo presentarse ademas sintomas mas graves hasta llegar a las convulsiones.

PRESENTACION : Frasco con 30 grageas de liberacion prolongada de 400 mg.

RECOMENDACIONES PARA ALMACENAMIENTO : Conservese el frasco bien tapado a temperatura ambiente a no mas de 30 °C y en lugar seco.

LEYENDAS DE PROTECCION : Esta contraindicado en mujeres embarazadas y lactando, no debera emplearse en pacientes que no toleran las metilxantinas como cafeina, teofilina o teobromina. El farmaco debera tomarse por un minimo de ocho semanas sin descontinuarlo. El medicamento debera descontinuarse si se presentan datos clinicos de sobredosis. Se recomienda administrar el farmaco con los alimentos para disminuir los problemas gastrointestinales. No se recomienda su uso en pacientes con alteraciones hepaticas o renales. Los pacientes sometidos a tratamiento con pentoxifilina deberan someterse a estudios periodicamente. El tratamiento con pentoxifilina esta indicado en pacientes que no son candidatos a tratamiento quirurgico. El paciente no debe fumar para no agravar su trastorno circulatorio.

El medicamento debera tragarse entero sin romperse, masticarse o triturarse. Los efectos secundarios o de intoxicacion pueden ser mas severos en los ancianos. El medicamento debera mantenerse lejos del alcance de los ninos.

NOMBRE DEL LABORATORIO Y DIRECCION : LABORATORIOS BEST. S. A. Alemania Num. 10 Colonia Independencia 03630 Mexico, D. F.

NUMERO DE REGISTRO DEL MEDICAMENTO : Reg. Num. 223M97, S. S. A. IV FEAR-110365/RM2002/IPPA

Publicado en: Farmacos



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Plantera - Official Terraria Wiki, Lantera

Plantera

Plantera creeps after the player, firing pink Seeds and eventually green Poison Seeds. These fire more rapidly as Plantera takes more damage. Plantera also begins to spit large, bouncing thorn balls after taking a certain amount of damage.

Second form Edit

Once Plantera is brought down to half of its original health, it changes to its second form, with its pink bud falling away to reveal a thorn-filled mouth. In this form, Plantera moves faster, and primarily attempts to make physical contact rather than fire ranged attacks.

It sprouts mouths that are attached via additional vines (called "Plantera's Tentacles").

It begins releasing floating pink spore projectiles that drift toward the player, similar to the spores released by the Giant Fungi Bulb .

Enraged behavior Edit

Plantera only becomes "enraged" if it follows the player out of the Underground Jungle. to the surface, or to the Underworld. This causes it to obtain double damage, double (quadruple in second form) defense and increased movement speed, as well as changing its attack patterns and directly rushing the player with its body. Plantera's behavior returns to normal upon reentry of the Underground Jungle biome.

In expert mode there are a few significant differences in Plantera's attacks, aside from the default increased health and damage.

Phase 1 Edit

Plantera's seeds, that originally didn't travel through blocks, now travel through them and do increased damage. The thorn balls are also more common and home in on the player.

Phase 2 Edit

Plantera's tentacles, originally only attached to the body, now are attached to the Hooks and have increased in number (considering there are 3 more for each hook, there appears to be 9 extra tentacles). They also have more health than usual (including the default increased health). Plantera's body also does more damage and is faster than normal.

A status message saying "Screams are echoing from the dungeon " will appear, signaling that new, more difficult enemy types will begin spawning in the Dungeon (see details ) . These drop new weapons, accessories, and other useful items. Dungeon Spirits will begin to appear when enemies with more than 100 health are slain in the dungeon, which drop Ectoplasm. a new crafting material that offers access to the Pumpkin Moon and Frost Moon events, as well as the Spectre Bars used to craft Spectre armor and tool sets.

The Great Southern Plantkill • "Defeat Plantera, the overgrown monstrosity of the jungle's depths."

If Plantera is currently summoned and you break another bulb, a second Plantera will not be summoned, though the bulb will be destroyed.

If Plantera has no surfaces to latch onto, it will slowly float off, going up into the space portion of the map, or until it hits a space where it can latch onto again.

If the player strays too far away from Plantera, it will despawn.

Plantera is immune to Poison. Venom. and Confusion Debuffs .

If the three mechanical bosses are defeated prior to the Wall of Flesh, then killing the Wall of Flesh is still required to trigger "The jungle grows restless."

The player should be especially cautious of Plantera's thorn balls, as they do significantly more damage in the Mobile version .

It is possible that a Mushroom Biome is growing, or The Corruption. The Crimson or The Hallow is infecting in the jungle. If so, Plantera will become enraged upon entering the biome, so it is best to not fight near any of these.

Plantera will also turn the same shade of orange it does when it has the Ichor debuff applied to it.

For more elaborate strategies on defeating Plantera, including Weapon and Arena recommendations, see Guide:Plantera strategies .

Excavate a sizable area to allow easier dodging before summoning Plantera.

Using a Gravitation Potion can help the player avoid any further damage from spiky balls laying on the ground, as the spiky balls obey gravity and fall to the floor.

Plantera's Bulb can spawn in player-made Jungle Biomes. which can provide a slightly easier way to fight Plantera.

Narrow passages slow Plantera as it takes more time for it to grip the surrounding terrain.

Plantera spawns off-screen and is quite easy to outrun, which means if the player intends for Plantera to chase them, they will need to stop periodically or move much more slowly than normal.

Widening a Bee Hive in the Underground Jungle is a fast and effective way of making an arena for fighting Plantera (but watch out for Larva ).

The Flamethrower could be considered for fighting Plantera due to the continuous stream of projectiles emitted, and is a pre-Plantera weapon which can easily be crafted after defeating Skeletron Prime .

A recommendation is Chlorophyte Arrow. as they bounce off walls, allowing the player to get multiple hits on Plantera.

Equipping a Cobalt Shield will help with melee attacks because Plantera won't knock the player away, but the player may receive more damage since Plantera can get closer.

Using an Unreal Megashark with cursed bullets is very useful.

Using Golden Shower to lower Plantera's defense is sure to make the fight less difficult. In addition, the Ichor debuff also allows you to make Plantera more visible, as it gives it a bright yellow shading.

The name "Plantera" is a play on the title of American metal band Pantera. which is Cenx 's favorite band. Plantera drops "The Axe ", which looks similar to the Washburn and Dean electric guitars often used by late Pantera guitarist Dimebag Darrell. Also, the achievement for defeating Plantera is called "The Great Southern Plantkill" in reference to the Pantera album "The Great Southern Trendkill".

Also, "Plantera" is Swedish for "Planting"

On the Console version the saving icon is one of the spiked balls that Plantera fires.

On the 3DS version, Plantera can drop the Zapinator. This appears to be a 3DS-exclusive drop.

1.3.0.4 . Fixed Plantera flag not triggering for non-english users.

1.3.0.1 .

Increased chance for The Axe to be dropped by Plantera from 0.5% to 2%.

Biome Chests can no longer be opened until Plantera is defeated.

Temple Keys are no longer required to make Biome Keys .

Added Expert Mode drop, Spore Sac .

Now has a chance to drop the Seedler .

In Expert Mode seeds fired from Plantera now travel through blocks.

1.2.4 . Fixed bug where "The jungle grows restless" message would appear before you have beaten all 3 Mech Bosses.

1.2.3 .

Now drops 15 .

Now despawns when all players have been killed.

Is now required to be killed in order to summon Golem from the Lihzahrd Altar .

Now has a chance to drop the Plantera Mask .

Plantera bulbs no longer spawn until all 3 Mech bosses are defeated.

1.2.1.2 .

Plantera is no longer needed for solar eclipses.

Its speed has been reduced.

Plantera now enrages when taken out of the Jungle or to the surface.

1.2.1.1 . When killed for the first time the message "Screams are echoing from the dungeon. " will now appear.

1.2.0.3.1 .

Fixed a problem that defeating plantera would force serverside characters.

Solar Eclipses now only happen after Plantera has been defeated.

1.2.0.3 .

Plantera now must be defeated to allow Hardmode dungeon enemies to spawn.

Hardmode Crimson, Corruption, and Hallow spread is now slowed after killing Plantera instead of any Mechanical Boss .

1.2 . Introduced.



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3. Q. Why sometimes name Zentavion happens in brackets? A. We are outside of the United States, and Zentavion can be issued under other name. Actually is too the medicine made by the same company under other name or a generic drug, made by other pharmaceutical company.

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They need to know if you have any of these conditions: kidney disease an unusual or allergic reaction to fexofenadine, terfenadine, other medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding

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Take this medicine by mouth with a full glass of water. You may take this medicine with food or on an empty stomach. Take your medicine at regular intervals. Do not take it more often than directed. You may need to take this medicine for several days before your symptoms improve.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years old for selected conditions, precautions do apply.

If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine? antacids erythromycin grapefruit, apple, or orange juice ketoconazole magnesium-containing products

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine. What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your health. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue breathing problems chest pain fast heartbeat infection or fever

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): cough drowsiness dry or irritated nose, mouth, or throat headache menstrual changes pain stomach upset, nausea

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klotaren

tiap kemasan klotaren mengandung zat aktif (nama generik) sebagai berikut :

Natrium diclofenac 25 mg / tablet

Natrium diclofenac 50 mg / tablet

Sekilas tentang zat aktif (nama generik)

Diklofenak (diclofenac) adalah nonsteroidal anti-inflammatory drug (NSAID) dengan nama kimia 2- (2,6-dichloranilino) asam fenilasetat. Diklofenak (diclofenac) bekerja dengan cara menghambat kerja enzim siklooksigenase (COX). Enzim ini berfungsi untuk membantu pembentukan prostaglandin saat terjadinya luka dan menyebabkan rasa sakit dan peradangan. Dengan menghalangi kerja enzim COX, prostaglandin lebih sedikit diproduksi, yang berarti rasa sakit dan peradangan akan mereda.

Indikasi klotaren

Kegunaan klotaren (diclofenac) adalah untuk membantu mengurangi nyeri, gangguan inflamasi (radang), dismenore, nyeri ringan sampai sedang pasca operasi khususnya ketika pasien juga mengalami peradangan.

Klotaren (diclofenac) juga digunakan untuk mengurangi rasa sakit pada penderita arthritis, rheumatoid arthritis, osteoarthritis, sakit gigi, migrain akut, asam urat dan nyeri karena batu ginjal dan batu empedu.

Klotaren (diclofenac) sering digunakan untuk mengurangi nyeri kronis pada penderita kanker

Kontra indikasi

jangan menggunakan klotaren (diclofenac) untuk pasien yang alergi terhadap klotaren (diclofenac), memiliki riwayat reaksi alergi (bronkospasme, shock, rhinitis, urtikaria) setelah penggunaan aspirin atau NSAID lainnya (misalnya, ibuprofen, celecoxib).

pasien yang akan atau telah menjalani operasi by-pass jantung sebaiknya jangan menggunakan klotaren (diclofenac).

obat ini juga dikontraindikasikan untuk pasien yang memiliki masalah ginjal, hati, atau radang / tukak pada lambung atau usus.

pasien yang sedang hamil terutama di 3 bulan terakhir, sebaiknya tidak menggunakan klotaren (diclofenac).

NSAID termasuk klotaren (diclofenac) tidak boleh diberikan untuk penderita demam berdarah, karena menginduksi kebocoran kapiler dan gagal jantung.

Efek Samping klotaren

Efek samping yang umum akibat pemakaian klotaren (diclofenac) adalah gangguan pada saluran gastrointestinal seperti mual, muntah, sembelit, nyeri perut, diare, dispepsia, kembung, perdarahan / perforasi, mulas, ulkus lambung dan duodenum. Dalam pemakaian jangka panjang pasien biasanya diberikan obat seperti misoprostol, ranitidine 150 mg, atau omeprazole 20 mg pada waktu tidur, sebagai pencegahan pendarahan gastrointestinal.

Orang-orang yang menderita gagal jantung, penyakit jantung atau stroke sebaiknya tidak menggunakan klotaren (diclofenac) meskipun banyak penelitian mengatakan efek samping diclofenac terhadap resiko terjadinya infark miokardial relatif kecil.

Efek samping pemakaian klotaren (diclofenac) pada organ hati jarang terjadi, dan biasanya reversibel. Meski demikian, kasus-kasus seperti nekrosis hati, sakit kuning, hepatitis fulminan dan gagal hati telah dilaporkan terjadi pada pemakaian jangka panjang dan dalam dosis yang lebih tinggi. Jika tes hati yang abnormal menetap atau memburuk, jika tanda-tanda dan gejala yang konsisten dengan penyakit hati klinis terjadi, atau jika manifestasi sistemik terjadi (misalnya. eosinofilia, ruam, dan lain – lain), pemakaian klotaren (diclofenac) harus dihentikan.

Efek samping klotaren (diclofenac) yang berkaitan dengan kesehatan mental adalah depresi, kecemasan, mudah marah, mimpi buruk, dan reaksi psikotik tetapi ini terjadi sangat jarang.

Seperti NSAID lainnya, klotaren(diclofenac) dapat menyebabkan luteinized sindrom folikel ruptur, yang menunda atau mencegah ovulasi. Oleh karena itu klotaren (diclofenac) dapat menyebabkan kemandulan yang sifatnya sementara pada wanita, terutama jika pemakaian obat-obat ini dilakukan dalam jangka panjang.

Kondisi-kondisi penekanan sumsum tulang seperti leukopenia, agranulositosis, thrombopenia dengan / tanpa purpura, anemia aplastik dapat terjadi tetapi sangat jarang. Meski demikian pasien yang menggunakan klotaren (diclofenac) harus memperhatikan kemungkinan ini, karena jika terjadi dapat berakibat fatal.

Anemia juga dilaporkan terjadi pada pasien yang menggunakan NSAID termasuk klotaren (diclofenac). Pasien pada pengobatan jangka panjang, kadar hemoglobin dan hematokrit harus diperiksa jika mereka menunjukkan tanda-tanda gejala anemia.

Reaksi dermatologis seperti dermatitis eksfoliatif, sindrom Stevens-Johnson, dan nekrolisis epidermal toksik, yang dapat berakibat fatal, dapat terjadi selama pemakaian NSAID termasuk klotaren (diclofenac). Pengobatan harus dihentikan jika tanda – tanda seperti ruam atau hipersensitivitas muncul.

Klotaren (diclofenac) juga dapat mengganggu siklus menstruasi normal.

Perhatian

Klotaren (diclofenac) sebaiknya dipakai setelah makan atau bersama makanan

Jika klotaren (diclofenac) diresepkan untuk pasien yang memiiki riwayat maag atau pendarahan gastrointestinal, resiko terjadinya perdarahan meningkat 10 kali lipat

Jangan menggunakan klotaren (diclofenac) pada pasien yang memiliki fungsi hati dan ginjal yang buruk, sedang atau pernah memiliki sakit jantung

Jika pasien menderita hipertensi tekanan darah harus dipantau selama pengobatan karena NSAID termasuk klotaren (diclofenac) dapat meningkatkan tekanan darah dan memperburuk kondisi hipertensi.

Karena NSAID dapat menyebabkan retensi cairan dan edema, perhatian harus diberikan pada pasien dengan gagal jantung atau yang sudah pernah mengalami retensi cairan

Pasien harus cukup terhidrasi (cukup cairan) sebelum menggunakan klotaren (diclofenac)

Penggunaan jangka panjang NSAID termasuk klotaren (diclofenac) dapat menyebabkan kerusakan ginjal.

Fungsi hati pasien harus dipantau secara teratur selama pemakaian klotaren (diclofenac) terutama jika digunakan dalam jangka waktu panjang

Keamanan dan kemanjuran pada anak-anak < 18 tahun belum diketahui

Penggunaan pada pasien lanjut usia harus lebih hati-hati karena mereka lebih sensitif terhadap efek obat ini, terutama perdarahan perut dan masalah ginjal

Belum diketahui apakah klotaren (diclofenac) diekskresikan melalui ASI. Tetapi mengingat efek yang buruk obat ini terhadap anak-anak sebaiknya jangan menyusui saat menggunakan obat ini

Klotaren (diclofenac) tidak boleh diberikan pada wanita hamil terutama pada trimester akhir karena dapat menyebabkan penutupan dini duktus arteriosus

Jika tanda-tanda reaksi anafilaksis (misalnya, kesulitan bernafas, pembengkakan wajah atau tenggorokan) selama pemakaian klotaren (diclofenac) terjadi, segera hubungi pihak medis

Toleransi terhadap kehamilan

Penelitian pada reproduksi hewan telah menunjukkan efek buruk pada janin dan tidak ada studi yang memadai dan terkendali dengan baik pada manusia, namun jika potensi keuntungan dapat dijamin, penggunaan obat pada ibu hamil dapat dilakukan meskipun potensi resiko sangat besar.

interaksi obat

Klotaren (diclofenac) berinteraksi dengan obat-obat berikut :

Antikoagulan (misalnya, warfarin dan heparin), aspirin, kortikosteroid (misalnya prednisone), atau selective serotonin reuptake inhibitor (SSRI) (misalnya, fluoxetine) karena obat – obat ini meningkatkan resiko perdarahan lambung

Siklosporin, lithium, methotrexate, kuinolon (misalnya, ciprofloxacin ), atau sulfonilurea (misalnya, glipizide) karena efek samping obat – obat ini meningkat jika diberikan bersamaan dengan klotaren (diclofenac)

Angiotensin-converting enzyme (ACE) inhibitor (misalnya, enalapril) atau diuretik (misalnya, furosemide, hydrochlorothiazide) karena efektivitas obat – obat ini menurun jika diberikan bersama klotaren (diclofenac)

Dosis klotaren

Klotaren (diclofenac) diberikan dengan dosis :

Dewasa. 75 – 150 mg / hari dibagi dalam 3 – 6 x dosis

Anak. 2 – 3 mg / kg BB / hari dibagi dalam 2 – 3 x dosis

dosis selengkapnya lihat diclofenac

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Airet Side Effects

For the Consumer

Applies to albuterol: oral syrup, oral tablet, oral tablet extended release

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by albuterol (the active ingredient contained in Airet). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking albuterol:

More common:

Shakiness in the legs, arms, hands, or feet

trembling or shaking of the hands or feet

Less common:

Fast, irregular, pounding, or racing heartbeat or pulse

Rare

Cough

difficulty breathing

difficulty with swallowing

hives or welts

hoarseness

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

noisy breathing

redness of the skin

shortness of breath

skin rash

slow or irregular breathing

swelling of the mouth or throat

tightness in the chest

wheezing

Incidence not known:

Agitation

anxiety

arm, back, or jaw pain

blurred vision

chest pain or discomfort

confusion

convulsions

extra heartbeats

fainting

hallucinations

headache

irritability

lightheadedness

mood or mental changes

muscle pain or cramps

muscle spasm or jerking of all extremities

nervousness

nightmares

pounding in the ears

restlessness

sudden loss of consciousness

sweating

total body jerking

unusual feeling of excitement

vomiting

Minor Side Effects

Some of the side effects that can occur with albuterol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

Dizziness

feeling of warmth

irritability

nausea

redness of the face, neck, arms, and occasionally, upper chest

sleeplessness

trouble with holding or releasing urine

trouble sleeping

unable to sleep

Rare

Sleepiness

unusual drowsiness

Incidence not known:

Bad, unusual, or unpleasant (after) taste

change in taste

feeling of constant movement of self or surroundings

gagging

rough, scratchy sound to voice

sensation of spinning

tightness in the throat

For Healthcare Professionals

Applies to albuterol: compounding powder, inhalation aerosol, inhalation aerosol with adapter, inhalation capsule, inhalation powder, inhalation solution, oral syrup, oral tablet, oral tablet extended release

General

Albuterol is generally well-tolerated and adverse effects seen are consistent with its pharmacological activity. In general, the severity of these adverse effects is dependent on the dose and route of administration. Administration by metered-dose inhaler (MDI) is associated with less systemic effects than administration of higher dosages orally or by nebulizer. Tolerance may develop to the adverse effects of albuterol (the active ingredient contained in Airet) [Ref ]

Cardiovascular

Changes in heart rate of approximately 20% may be produced by 0.18 mg of albuterol (the active ingredient contained in Airet) by MDI. Aggravation of angina may be due to tachycardia produced by albuterol. Atrial fibrillation was reported in one patient when a spacer device was utilized with an albuterol inhaler, thus increasing the available dose for systemic absorption. Supraventricular ectopic beats and ventricular tachycardia have also been reported. Higher doses of albuterol should be used with caution in patients with cardiac disease, arrhythmias, or hypertension. All of these effects are dose-related and lower doses may be tolerated. [Ref ]

The cardiovascular side effects have included palpitations, peripheral vasodilatation and reflex tachycardia with blood pressure increasing or decreasing. Albuterol in higher dosages has been reported to aggravate angina, myocardial ischemia, or cause atrial or ventricular arrhythmias. Pulmonary edema has been reported in pregnant patients receiving intravenous albuterol. Postmarketing reports have included hypotension. [Ref ]

Musculoskeletal

Musculoskeletal side effects have included tremors, particularly at higher dosages. Tolerance can develop to the tremorogenic effects. Severe muscle cramping may occur infrequently. [Ref ]

Metabolic

Following doses of 15 mg albuterol (the active ingredient contained in Airet) via nebulizer, hyperkalemic patients on hemodialysis experienced a 0.9 mEq/L decrease in plasma potassium which was sustained for 6 hours. Albuterol may stimulate sodium-potassium ATPase, resulting in an intracellular shift of potassium.

Transient lactic acidosis has been reported after administration of inhaled albuterol for an asthma attack. [Ref ]

Metabolic side effects have included hypokalemia, and less commonly, hyperglycemia and lactic acidosis. Postmarketing reports have included metabolic acidosis. Diabetic ketoacidosis has been reported due to overdose of albuterol. [Ref ]

Nervous system

Nervous system side effects have included restlessness, anxiety, nervousness, irritability, and insomnia. Postmarketing reports have included tremor. [Ref ]

Psychiatric

Psychiatric side effects have included psychoses presenting as auditory hallucinations and persecutory delusions. These effects are generally associated with higher dosages. [Ref ]

Other

Concern over the development of tachyphylaxis to the bronchodilating effects of albuterol (the active ingredient contained in Airet) has been expressed. Although conflicting data exist, complete tolerance has not been reported. [Ref ]

Respiratory

Respiratory side effects have included paradoxical bronchospasm. [Ref ]

References

1. Larsson S, Svedmyr N "Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol inasthmatics." Am Rev Respir Dis 116 (1977): 861-9

2. Price AH, Clissold SP "Salbutamol in the 1980s. A reappraisal of its clinical efficacy." Drugs 38 (1989): 77-122

3. "Albuterol." Med Lett Drugs Ther 23 (1981): 81-2

4. Godfrey S "Worldwide experience with albuterol (salbutamol)." Ann Allergy 47 (1981): 423-6

5. Meyer MF, Hopkins WE, Kaminsky DA "Cardiovascular collapse in a 77-year-old-woman with an asthma exacerbation following bronchodilator treatment." Chest 124 (2003): 1160-3

6. Vathenen AS, Britton JR, Ebden P, Cookson JB, Wharrad HJ, Tattersfield AE "High-dose inhaled albuterol in severe chronic airflow limitation." Am Rev Respir Dis 138 (1988): 850-5

7. Jenne JW "Can oral beta(2) agonists cause heart failure?" Lancet 352 (1998): 1081-2

8. Breeden CC, Safirstein BH "Albuterol and spacer-induced atrial fibrillation." Chest 98 (1990): 762-3

9. Davies AE, Robertson MJ "Pulmonary oedema after the administration of intravenous salbutamol and ergometrine. Case report." Br J Obstet Gynaecol 87 (1980): 539-41

10. Kallergis EM, Manios EG, Kanoupakis EM, et al. "Acute electrophysiologic effects of inhaled salbutamol in humans." Chest 127 (2005): 2057-63

11. Neville E, Corris PA, Vivian J, Nariman S, Gibson GJ "Nebulised salbutamol and angina." Br Med J (Clin Res Ed) 285 (1982): 796-7

12. Hawker F "Five cases of pulmonary oedema associated with beta 2-sympathomimetic treatment of premature labour." Anaesth Intensive Care 12 (1984): 159-62

13. Mettauer B, Rouleau JL, Burgess JH "Detrimental arrhythmogenic and sustained beneficial hemodynamic effects of oral salbutamol in patients with chronic congestive heart failure." Am Heart J 109 (1985): 840-7

14. Shovlin CL, Tam FW "Salbutamol nebuliser and precipitation of critical cardiac ischaemia." Lancet 336 (1990): 1258

15. Lipworth BJ, Struthers AD, McDevitt DG "Tachyphylaxis to systemic but not to airway responses during prolonged therapy with high dose inhaled salbutamol in asthmatics." Am Rev Respir Dis 140 (1989): 586-92

16. Finch JS "Cardiovascular toxicity: clinical evaluation of albuterol, isoproterenol and placebo in rising dose tolerance trial." Ann Allergy 47 (1981): 402-4

17. Chazan R, Droszcz W, Maruchin JE "Pharmacodynamics of salbutamol in humans." Int J Clin Pharmacol Ther Toxicol 26 (1988): 385-7

18. Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9

19. Tan SN "Peri-partum pulmonary oedema." Anaesth Intensive Care 19 (1991): 111-3

20. Larsson S "Long-term treatment with beta2-adrenostimulants in asthma. Side effects, selectivity, tolerance, and routes of administration." Acta Med Scand Suppl 608 (1977): 1-40

21. Lisi DM "Muscle spasms and creatine phosphokinase elevation following salbutamol administration." Eur Respir J 2 (1989): 98

22. Craig TJ, Smits W, Soontornniyomkiu V "Elevation of creatine kinase from skeletal muscle associated with inhaled albuterol." Ann Allergy Asthma Immunol 77 (1996): 488-90

23. Stratakos G, Kalomenidis J, Routsi C, Papiris S, Roussos C "Transient lactic acidosis as a side effect of inhaled salbutamol." Chest 122 (2002): 385-6

24. Kantola I, Tarssanen L "Hypokalemia from usual salbutamol dosage ." Chest 89 (1986): 619-20

25. Hastwell G, Lambert BE "The effect of oral salbutamol on serum potassium and blood sugar." Br J Obstet Gynaecol 85 (1978): 767-9

26. Allon M, Dunlay R, Copkney C "Nebulized albuterol for acute hyperkalemia in patients on hemodialysis." Ann Intern Med 110 (1989): 426-9

27. Rakhmanina NY, Kearns GL, Farrar HC "Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler." Pediatr Emerg Care 14 (1998): 145-7

28. Montoliu J, Almirall J, Ponz E, Campistol JM, Revert L "Treatment of hyperkalaemia in renal failure with salbutamol inhalation." J Intern Med 228 (1990): 35-7

29. Habib GS, Saliba WR, Cohen L "Diabetic ketoacidosis associated with oral salbutamol overdose." Am J Med 113 (2002): 701-2

30. "Hypokalaemia due to salbutamol overdosage." Br Med J (Clin Res Ed) 283 (1981): 500-1

31. Liem EB, Mnookin SC, Mahla ME "Albuterol-induced Lactic Acidosis." Anesthesiology 99 (2003): 505-506

32. Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71

33. Whitehouse AM, Novosel S "Salbutamol psychosis." Biol Psychiatry 26 (1989): 631-3

34. Hall RC, Beresford TP, Stickney SK, Nasdahl CS, Coleman JH "Psychiatric reactions produced by respiratory drugs." Psychosomatics 26 (1985): 605-8,616-7

35. Ray I, Evans CJ "Paranoid psychosis with Ventolin (salbutamol tablets b. p.)." Can Psychiatr Assoc J 23 (1978): 427

36. Martin W, Unutzer J, Szuba MP "Exacerbation of psychosis associated with inhaled albuterol." J Clin Psychopharmacol 15 (1995): 446-7

37. Svedmyr N, Lofdahl CG "The use of beta(2)-adrenoceptor agonists in the treatment of bronchial asthma." Pharmacol Toxicol 78 (1996): 3-11

38. Yates DH, Kharitonov SA, Barnes PJ "An inhaled glucocorticoid does not prevent tolerance to the bronchoprotective effect of a long-acting inhaled beta(2)-agonist." Am J Respir Crit Care Med 154 (1996): 1603-7

39. Sears MR, Taylor DR, Print CG, et al. "Regular inhaled beta-agonist treatment in bronchial asthma." Lancet 336 (1990): 1391-5

40. Cockcroft DW, Swystun VA "Functional antagonism: tolerance produced by inhaled beta(2) agonists." Thorax 51 (1996): 1051-6

41. Drazen JM, Israel E, Boushey HA, et al. "Comparisons of regularly scheduled with as-needed use of albuterol in mild asthma." N Engl J Med 335 (1996): 841-7

42. van Schayck CP, Dompeling E, van Herwaarden CL, et al. "Bronchodilator treatment in moderate asthma or chronic bronchitis: continuous or on demand? A randomised controlled study." BMJ 303 (1991): 1426-31

43. Raghunathan K, Nagajothi N "Paradoxical bronchospasm: a potentially life threatening adverse effect of albuterol." South Med J 99 (2006): 288-9

Not all side effects for Airet may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .



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Resilo Guide - Resilo, Resilo

ReSilo Guide

Framework Categories

the framework should be used to inspire unique ReSilo solutions, which are relatable to the sites specific context.

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Moving To: XX address

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