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About Amit, Amit

What is AMIT?

Advanced Muscle Integration Technique (AMIT) is a systematic treatment of common joint and muscle conditions experienced by active people. AMIT is a revolutionary advancement in sports medicine.

AMIT practitioners can predict injuries by examining and identifying instabilities in the body, which in most cases lead to injury. The new advanced therapies utilized in AMIT procedures allow for rapid corrections of instabilities resulting in improved function, removal of pain and an overall new level of performance.

The developers of the AMIT system discovered the primary cause of chronic joint pain and muscle pain is due to inhibited muscles due to overuse or injury. Although the pain of the injury goes away over time, the functional imbalance remains and in turn these functional imbalances eventually lead to chronic pain. By defining these imbalances and correcting them using the AMIT therapies, healing and rehabilitation can take place rapidly without the need for drugs or surgery.

There is no reason why people cannot be active into their 80s. You owe it to yourself to discover why top athletes and people from all over the world are willing to come to Kaysville, Utah to be treated by Dr. Buhler and associates. We look forward to meeting you.

Dr Craig Buhler

Mission Statement

Our mission is to accelerate healing to maximize function and human performance by integrating the structural, chemical and electromagnetic systems of the body. We predict and prevent injuries by defining vulnerabilities through an Innate Intelligence guided systems approach to assessment, diagnosis and therapy.

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Guiding Principles

Philosophy

Our bodies are perfectly designed to produce the experience we get.

Pain or dysfunction is the result of modification to your body’s innate design. Modifications are due to an accumulation of imbalances caused by traumas and overloads to your body’s systems.

There is always a reason for symptoms. Ignore them long enough, disease and injury will be the result.

Symptoms are a precise language warning system built into the body to protect it.

Treating symptoms with unnecessary medications/drugs and surgeries is in essence telling the body to be quiet. This approach can lead to more serious conditions over time.

There are crisis situations, which require medications/drugs and surgeries. Medication should be used only as a stop gap measure until a solution can be defined to correct the cause of the problem. Surgery should be used only to correct pathology and not in an effort to remove the symptom of pain or improve function.

We attempt to define the root cause of the problem rather than merely treat the symptom.

Science – The foundation upon which Advanced Muscle Integration Technique is based:

When a muscle is overloaded beyond its ability to sustain the load, one of two things happen. The muscle fibers tear and/or the nervous system inhibits the muscle. Much like a circuit breaker in an electrical circuit. This is done to protect the muscle from more severe injury.

If the inhibited muscle is loaded again during physical activity it will not be able to contract appropriately to support the force applied and will be weak. If the muscle continues to be stressed, the body will create pain so as to avoid more damage.

Once a muscle is inhibited, the central nervous system develops an adaptive strategy to use other muscles or tissues to take on more of the load. This leads to adaptive movement patterns and is called " recruitment" or "adaptation". The adapted tissue becomes the next site of injury and the injury/adaptation cycle continues.

Eventually, there will be no muscles in an area to adapt to. This places more stress on the ligaments and connective tissues and they begin to break down more rapidly. Leading to degenerative changes in the joint.

Functional testing of isolated muscles defines positions of instability.

Isolated muscle weakness leads to joint instability and restricted range of motion. The body will not allow motion that cannot be stabilized.

Muscle tightness restricts motion and is a symptom of neurological inhibition of the antagonist muscles.

Flexibility therapies increase range of motion but do nothing to improve stability. This can lead to further injury.

Adaptation

The absence of symptoms does not indicate healing is complete. It may only indicate the body has merely created a successful adaptation into other tissues or systems. Adaptation leads to less efficient function.

If an acute injury is not corrected within six weeks, the central nervous system is forced to adapt the body.

Acute injuries will be treated at the local injury site. Chronic problems will always require treatment away from the symptom site.

The symptom site may be the chronic adaptation site and may not respond to therapy.

Adapted tissues become the next site of symptom and eventual injury.

Treating adaptation sites does not improve function. If healing is to take place, all the essential components for healing must be present.

If all the essential components for healing are not available, the injured tissue will be put on hold resulting in more adaptation.

This leads to an accumulation of problems; adaptive overlay of injuries and adaptations creating a layering effect.

History of AMIT

Dr. Alan G. Beardall was born September 7, 1938 and his untimely death occurred December 1, 1987 in an automobile accident. He was one of the original Diplomats in the International College of Applied Kinesiology and was a genius behind the AMIT method.

"You should never have to treat the same muscle twice," he would teach. "If you found the same problem recurring, you have missed something and need to dig deeper into the body's systems for the answer as to why your treatment did not hold." - Dr. Alan Beardall

The body was Dr. Beardall’s laboratory and teacher. He was always in awe of how wondrous the body was, how it could display truths if asked the right questions. He posed questions by challenging muscle function conditions, defining range of motion restrictions and evaluating the details of a patient’s symptoms. This became the "biological language system" used in the AMIT model.

Dr. Beardall was a nationally ranked distance runner and never missed a day of running the roads. Because of his involvement in running, he drew many of the nation’s elite runners to his office in Lake Oswego, Oregon. As a result, he was presented with many difficult and chronic athletic injuries.

Dr. Beardall was a perfectionist, which was the driving force that led him to never be satisfied with anything less than maximum function and pain free performance in his patients. He worked tirelessly for years defining and refining the work that became known as Clinical Kinesiology or CK. CK is a system that enables physicians the ability to isolate and test 310 unilateral muscles in the body for function. He expanded our understanding of anatomy by re-discovering the anatomical divisions of muscles that were lost in anatomy books by editors' desire to simplify anatomy. In addition, he discovered systems related to each of the 310 muscles. This revolutionized human performance analysis and treatment.

Never satisfied until he figured out the cause of a patient’s condition, Dr. Beardall studied every technique he could in the healing arts. He had the uncanny ability to see the truth. An intuitive genius, his connection with a higher source seemed to lead and teach him based on the questions he was asking. If he had difficult patient that had him stumped, he would pour over volumes of journals while his family slept, searching for answers. By the patient’s next visit, Dr. Beardall was ready to work through his new discoveries to see if the patient would respond in a positive way.

Over the course of several years, problems that once stifled him became easy to correct. As each new challenge presented itself in his clinic, he faced it with the same drive to understand and succeed. In April 1982 Beardall published the first of a series of Clinical Kinesiology manuals with all the reflex points and muscle test for each of the muscle divisions. He held his first seminar in Bandera, Texas on muscles of the temporomandibular joint.

Through it all, CK became the base on which AMIT was developed. Dr. Beardall has been greatly missed yet his passing opened the opportunity for others to grow and develop as we followed in his footsteps.

The AMIT method was developed using Alan’s work with the Utah Jazz basketball team over a 26 year period. The challenges of professional basketball injuries put the work to the ultimate test. Through the process new insights developed in how to process an acute injuries. Acute injuries it turned out seemed easy to fix. The challenge was in the process for chronic injuries. The research we did at the University of Utah medical school physiology and dissection labs revealed new insights as to how the muscles and connective tissue related to each other. These insights lead to the understanding of how to correct chronic conditions that were so hard to resolve.

The results were not only the rapid correction of acute injuries and the removal of long standing chronic conditions, but improved athletic performance and low injury rates. The AMIT method with its genesis in Clinical Kinesiology is quickly becoming the standard of care for athletic injuries and human performance improvement and will revolutionize how we approach sports medicine and sports chiropractic.



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Lasix (Inclens)

Lasix is used for treating high blood pressure or water retention (swelling) associated with congestive heart failure, liver disease, or kidney disease. Lasix is a loop diuretic. Loop diuretics make the kidneys eliminate larger amounts of electrolytes (especially sodium and potassium salts) and water than normal (diuretic effect). Loop diuretics are useful for treating many conditions in which salt and water retention (eg, edema, swelling) are a problem.

Use Lasix as directed by your doctor.

Take Lasix by mouth with or without food.

If you take cholestyramine, colestipol, or sucralfate, ask your doctor or pharmacist how to take them with Lasix.

Lasix may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.

If you miss a dose of Lasix, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lasix.

Store Lasix at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat and moisture in a tight, light-resistant container. Exposure to light may cause a slight discoloration. Do not take discolored tablets. Do not store in the bathroom. Keep Lasix out of the reach of children and away from pets.

Active Ingredient: Furosemide.

Do NOT use Lasix if:

you are allergic to any ingredient in Lasix

you are unable to urinate

you are taking ethacrynic acid.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Lasix. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have fluid in your abdomen (ascites), hearing problems, liver disease, diabetes, low urine output, kidney problems, lupus, gout, abnormal blood electrolyte levels, high blood uric acid levels, or the blood disease porphyria

if you have had a heart attack, are dehydrated, or are on a low-salt diet.

Some medicines may interact with Lasix. Tell your health care provider if you are taking any other medicines, especially any of the following:

Corticosteroids (eg, prednisone) or corticotropin (ACTH) because the risk of low blood potassium levels may be increased

Barbiturates (eg, phenobarbital) or narcotics (eg, codeine) because the risk of dizziness upon standing may be increased

Aminoglycosides (eg, gentamicin), amphotericin B, angiotensin-converting enzyme (ACE) inhibitors (eg, captopril), cyclosporine, ethacrynic acid, tacrolimus, or vancomycin because serious side effects to the kidneys (decreased ability to urinate) or ears (hearing loss) may occur

Chloral hydrate because side effects, such as excessive sweating, rapid heartbeat, and changes in blood pressure, may occur

Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin) because they may decrease Lasix's effectiveness

Digoxin, lithium, medicines for high blood pressure, salicylates (eg, aspirin), or succinylcholine because the risk of their side effects may be increased by Lasix

Norepinephrine or tubocurarine because their effectiveness may be decreased by Lasix.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lasix may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Lasix may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Lasix with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Lasix may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Diabetes patients - Lasix may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Tell your doctor or dentist that you take Lasix before you receive any medical or dental care, emergency care, or surgery.

Your doctor may also prescribe a potassium supplement while you take Lasix. Check with your doctor before you use a salt substitute or other product that has potassium in it.

Lasix is a strong diuretic. Using too much of this drug can lead to serious water and mineral loss. Therefore, it is important that you be monitored by your doctor. Promptly notify your doctor if you become very thirsty, have a dry mouth, become confused, or develop muscle cramps/weakness.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.

Lasix may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Lasix. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Lab tests, including blood pressure and complete blood counts, may be performed while you use Lasix. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Lasix with caution in the elderly; they may be more sensitive to its effects, especially dehydration.

Caution is advised when using Lasix in children; they may be more sensitive to its effects.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lasix while you are pregnant. Lasix is found in breast milk. If you are or will be breast-feeding while you use Lasix, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Dizziness; lightheadedness; sensitivity to sunlight.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); calf pain or tenderness; confusion; dark urine; decreased or persistent increased urination; drowsiness; dry mouth; fast or irregular heartbeat; fever, chills, or sore throat; hearing decrease or loss; muscle pain/cramps/weakness; restlessness; ringing in the ears; severe or persistent nausea, vomiting, or dizziness; shortness of breath; sluggishness; stomach pain; unusual bleeding or bruising; unusual thirst or hunger; unusual tiredness or weakness; vein inflammation; yellow vision; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Feldene (Piroxicam) Medical Facts From, Felden

Feldene

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation.

Piroxicam is used to treat pain or inflammation caused by osteoarthritis or rheumatoid arthritis.

Piroxicam may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Feldene (piroxicam)?

Piroxicam can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Piroxicam may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using piroxicam, especially in older adults.

What should I discuss with my healthcare provider before taking Feldene (piroxicam)?

You should not use piroxicam if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Piroxicam can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Piroxicam may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using piroxicam, especially in older adults.

To make sure piroxicam is safe for you, tell your doctor if you have:

heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;

a history of heart attack, stroke, or blood clot;

a history of stomach ulcers or bleeding;

liver or kidney disease; or

Taking piroxicam during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant.

Ovulation (release of an egg from your ovary) could be delayed while you are taking piroxicam. This effect is usually not permanent. You should not take piroxicam while you are trying to get pregnant.

Piroxicam can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Piroxicam is not approved for use by anyone younger than 18 years old.

How should I take Feldene (piroxicam)?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

It may take up to 2 weeks before your symptoms improve. Keep using the medicine as directed and tell your doctor if your symptoms do not improve.

If you use this medicine long-term, you may need frequent medical tests.

Store at room temperature away from moisture and heat.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, stomach pain, black or bloody stools, or coughing up blood.

What should I avoid while taking Feldene (piroxicam)?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin while you are taking piroxicam.

Ask a doctor or pharmacist before using any cold, allergy, or pain medicine. Many medicines available over the counter contain aspirin or other medicines similar to piroxicam. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.

Feldene (piroxicam) side effects

Get emergency medical help if you have signs of an allergic reaction: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Stop using piroxicam and call your doctor at once if you have:

changes in your vision;

shortness of breath (even with mild exertion);

swelling or rapid weight gain;

the first sign of any skin rash, no matter how mild;

signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;

low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or

severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

abnormal liver function tests;

upset stomach, heartburn, loss of appetite, stomach pain, nausea, vomiting;

gas, diarrhea, constipation;

itching, rash; or

ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Feldene (piroxicam)?

Ask your doctor before using piroxicam if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Ask a doctor or pharmacist if it is safe for you to use piroxicam if you are also using any of the following drugs:

a blood thinner (warfarin, Coumadin, Jantoven);

heart or blood pressure medication, including a diuretic or "water pill"; or

steroid medicine (such as prednisone).

This list is not complete. Other drugs may interact with piroxicam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

More about Feldene (piroxicam)

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about piroxicam.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 10.01. Revision Date: 2015-08-27, 4:44:05 PM.

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Milithin, Lithium Carbonate, Milithin

Milithin

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(lithium carbonate) is indicated in the treatment of manic episodes of manic-depressive illness. Maintenance therapy prevents or diminishes the intensity of subsequent episodes in those manic-depressive patients with a history of mania. Typical symptoms of mania include pressure of speech, motor hyperactivity, reduced need for sleep, flight of ideas, grandiosity, elation, poor judgment, aggressiveness and possibly hostility. When given to a patient experiencing a manic episode, (lithium carbonate) may produce a normalization of symptomatology within 1 to 3 weeks.

Lithium should generally not be given to patients with significant renal or cardiovascular disease, severe debilitation or dehydration, or sodium depletion, and to patients receiving diuretics, since the risk of lithium toxicity is very high in such patients. If the psychiatric indication is life-threatening, and if such a patient fails to respond to other measures, lithium treatment may be undertaken with extreme caution, including daily serum lithium determinations and adjustment to the usually low doses ordinarily tolerated by these individuals. In such instances, hospitalization is a necessity.

The occurrence and severity of adverse reactions are generally directly related to serum lithium concentrations as well as to individual patient sensitivity to lithium, and generally occur more frequently and with greater severity at higher concentrations. Adverse reactions may be encountered at serum lithium levels below 1.5 mEq/L. Mild to moderate adverse reactions may occur at levels from 1.5 to 2.5 mEq/L, and moderate to severe reactions may be seen at levels of 2.0 mEq/L and above. Fine hand tremor, polyuria, and mild thirst may occur during initial therapy for the acute manic phase, and may persist throughout treatment. Transient and mild nausea and general discomfort may also appear during the first few days of lithium administration. These side effects usually subside with continued treatment or a temporary reduction or cessation of dosage. If persistent, cessation of lithium therapy may be required. Diarrhea, vomiting, drowsiness, muscular weakness, and lack of coordination may be early signs of lithium intoxication, and can occur at lithium levels below 2.0 mEq/L. At higher levels, ataxia, giddiness, tinnitus, blurred vision, and a large output of dilute urine may be seen. Serum lithium levels above 3.0 mEq/L may produce a complex clinical picture, involving multiple organs and organ systems. Serum lithium levels should not be permitted to exceed 2.0 mEq/L during the acute treatment phase. The following reactions have been reported and appear to be related to serum lithium levels, including levels within the therapeutic range: Neuromuscular/Central Nervous System: Tremor, muscle hyperirritability (fasciculations, twitching, clonic movements of whole limbs), hypertonicity, ataxia, choreo-athetotic movements, hyperactive deep tendon reflex, extrapyramidal symptoms including acute dystonia, cogwheel rigidity, blackout spells, epileptiform seizures, slurred speech, dizziness, vertigo, downbeat nystagmus, incontinence of urine or feces, somnolence, psychomotor retardation, restlessness, confusion, stupor, coma, tongue movements, tics, tinnitus, hallucinations, poor memory, slowed intellectual functioning, startled response, worsening of organic brain syndromes, myasthenia gravis (rarely). Cardiovascular: Cardiac arrhythmia, hypotension, peripheral circulatory collapse, bradycardia, sinus node dysfunction with severe bradycardia (which may result in syncope). Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, gastritis, salivary gland swelling, abdominal pain, excessive salivation, flatulence, indigestion. Genitourinary: Glycosuria, decreased creatinine clearance, albuminuria, oliguria, and symptoms of nephrogenic diabetes insipidus including polyuria, thirst and polydipsia. Dermatologic: Drying and thinning of hair, alopecia, anesthesia of skin, acne, chronic folliculitis, xerosis cutis, psoriasis or its exacerbation, generalized pruritus with or without rash, cutaneous ulcers, angioedema. Autonomic: Blurred vision, dry mouth, impotence/sexual dysfunction. Thyroid Abnormalities: Euthyroid goiter and/or hypothyroidism (including myxedema) accompanied by lower T3 and T4. I131 uptake may be elevated. (See PRECAUTIONS.) Paradoxically, rare cases of hyperthyroidism have been reported. EEG Changes: Diffuse slowing, widening of the frequency spectrum, potentiation and disorganization of background rhythm. EKG Changes: Reversible flattening, isoelectricity or inversion of T-waves. Miscellaneous: Fatigue, lethargy, transient scotomata, exophthalmos, dehydration, weight loss, leukocytosis, headache, transient hyperglycemia, hypercalcemia, hyperparathyroidism, excessive weight gain, edematous swelling of ankles or wrists, metallic taste, dysgeusia/taste distortion, salty taste, thirst, swollen lips, tightness in chest, swollen and/or painful joints, fever, polyarthralgia, dental caries. Some reports of nephrogenic diabetes insipidus, hyperparathyroidism, and hypothyroidism which persist after lithium discontinuation have been received. A few reports have been received of the development of painful discoloration of fingers and toes and coldness of the extremities within one day of the starting of treatment with lithium. The mechanism through which these symptoms (resembling Raynaud’s syndrome) developed is not known. Recovery followed discontinuance. Cases of pseudotumor cerebri (increased intracranial pressure and papilledema) have been reported with lithium use. If undetected, this condition may result in enlargement of the blind spot, constriction of visual fields, and eventual blindness due to optic atrophy. Lithium should be discontinued, if clinically possible, if this syndrome occurs.

Caution should be used when lithium and diuretics are used concomitantly because diuretic-induced sodium loss may reduce the renal clearance of lithium and increase serum lithium levels with risk of lithium toxicity. Patients receiving such combined therapy should have serum lithium levels monitored closely and the lithium dosage adjusted if necessary. Lithium levels should be closely monitored when patients initiate or discontinue NSAID use. In some cases, lithium toxicity has resulted from interactions between an NSAID and lithium. Indomethacin and piroxicam have been reported to increase significantly steady-state plasma lithium concentrations. There is also evidence that other nonsteroidal anti-inflammatory agents, including the selective cyclooxygenase-2 (COX-2) inhibitors, have the same effect. In a study conducted in healthy subjects, mean steady-state lithium plasma levels increased approximately 17% in subjects receiving lithium 450 mg b. i.d. with celecoxib 200 mg b. i.d. as compared to subjects receiving lithium alone. Concurrent use of metronidazole with lithium may provoke lithium toxicity due to reduced renal clearance. Patients receiving such combined therapy should be monitored closely. There is evidence that angiotensin-converting enzyme inhibitors, such as enalapril and captopril, and angiotension II receptor antagonists, such as losartan, may substantially increase steady-state plasma lithium levels, sometimes resulting in lithium toxicity. When such combinations are used, lithium dosage may need to be decreased, and plasma lithium levels should be measured more often. Concurrent use of calcium channel blocking agents with lithium may increase the risk of neurotoxicity in the form of ataxia, tremors, nausea, vomiting, diarrhea, and/or tinnitus. Caution is recommended. The concomitant administration of lithium with selective serotonin reuptake inhibitors should be undertaken with caution as this combination has been reported to result in symptoms such as diarrhea, confusion, tremor, dizziness, and agitation. The following drugs can lower serum lithium concentrations by increasing urinary lithium excretion: acetazolamide, urea, xanthine preparations, and alkalinizing agents such as sodium bicarbonate. The following have also been shown to interact with lithium: methyldopa, phenytoin, and carbamazepine.

Usage in Pregnancy: Adverse effects on implantation in rats, embryo viability in mice and metabolism in vitro of rat testes and human spermatozoa have been attributed to lithium, as have teratogenicity in submammalian species and cleft palates in mice. In humans, lithium carbonate may cause fetal harm when administered to a pregnant woman. Data from lithium birth registries suggest an increase in cardiac and other anomalies, especially Ebstein’s anomaly. If this drug is used in women of childbearing potential, or during pregnancy, or if a patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Usage in Nursing Mothers: Lithium is excreted in human milk. Nursing should not be undertaken during lithium therapy except in rare and unusual circumstances where, in the view of the physician, the potential benefits to the mother outweigh possible hazards to the child. Usage in Pediatric Patients: Since information regarding the safety and effectiveness of lithium carbonate in children under 12 years of age is not available, its use in such patients is not recommended. There has been a report of a transient syndrome of acute dystonia and hyperreflexia occurring in a 15 kg child who ingested 300 mg of lithium carbonate. Usage in the Elderly: Elderly patients often require lower lithium dosages to achieve therapeutic serum levels. They may also exhibit adverse reactions at serum levels ordinarily tolerated by younger patients. General: The ability to tolerate lithium is greater during the acute manic phase and decreases when manic symptoms subside (See DOSAGE AND ADMINISTRATION). The distribution space of lithium approximates that of total body water. Lithium is primarily excreted in urine with insignificant excretion in feces. Renal excretion of lithium is proportional to its plasma concentration. The half-life of elimination of lithium is approximately 24 hours. Lithium decreases sodium reabsorption by the renal tubules which could lead to sodium depletion. Therefore, it is essential for the patient to maintain a normal diet, including salt, and an adequate fluid intake (2,500 to 3,000 mL) at least during the initial stabilization period. Decreased tolerance to lithium has been reported to ensue from protracted sweating or diarrhea and, if such occur, supplemental fluid and salt should be administered under careful medical supervision and lithium intake reduced or suspended until the condition is resolved. In addition to sweating and diarrhea, concomitant infection with elevated temperatures may also necessitate a temporary reduction or cessation of medication. Previously existing underlying thyroid disorders do not necessarily constitute a contraindication to lithium treatment; where hypothyroidism exists, careful monitoring of thyroid function during lithium stabilization and maintenance allows for correction of changing thyroid parameters, if any; where hypothyroidism occurs during lithium stabilization and maintenance, supplemental thyroid treatment may be used.

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Lidocaine

Causing loss of feeling during certain procedures. It may also be used for other conditions as determined by your doctor.

Lidocaine is an anesthetic. It works by preventing nerves from transmitting painful impulses to the brain.

Do NOT use lidocaine if:

you are allergic to any ingredient in lidocaine or to similar medications (eg, amide-type local anesthetics)

Contact your doctor or health care provider right away if any of these apply to you.

Before using lidocaine:

Some medical conditions may interact with lidocaine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have liver problems, bleeding problems, or a platelet disorder

if you are very sensitive to anesthetics

Some MEDICINES MAY INTERACT with lidocaine. However, no specific interactions with lidocaine are known at this time.

Ask your health care provider if lidocaine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use lidocaine:

Use lidocaine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Lidocaine is usually given at your doctor's office, hospital, or clinic.

If you miss a dose of lidocaine, contact your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use lidocaine.

Important safety information:

Avoid driving and doing other tasks or actions that call for you to be alert until you see how lidocaine affects you.

Lidocaine is for external use only. Do not get it in your eyes, nose, or mouth. If you get it in any of these areas, rinse at once with cool water.

Do not put on open sores or broken skin.

You may hear a sound like a popping balloon when lidocaine is used. This is normal.

PREGNANCY and BREAST-FEEDING: It is not known if lidocaine can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using lidocaine while you are pregnant. Lidocaine is found in breast milk. If you are or will be breast-feeding while you use lidocaine, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of lidocaine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild itching, redness, or swelling where lidocaine was used; small red or purple spots on the skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bruising, burning, pain, or bleeding where lidocaine was used; severe or persistent itching, redness, or swelling where lidocaine was used.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately.

Proper storage of lidocaine:

Lidocaine is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.

General information:

If you have any questions about lidocaine, please talk with your doctor, pharmacist, or other health care provider.

Lidocaine is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take lidocaine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about lidocaine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to lidocaine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using lidocaine.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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Tranexamic Acid 500mg, Ugurol

TRANEXAMIC ACID 500MG/5ML SOLUTION FOR INJECTION

3. How Tranexamic Injection is given

Package leaflet: information for the patient

Tranexamic Acid 500mg/5ml Solution for Injection

• Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor or nurse. • If you get any side effects, talk to your doctor or nurse. This includes any possible side effects not listed in this leaflet.

What is in this leaflet:

1. What Tranexamic Acid Solution for Injection is and what it is used for 2. What you need to know before you are given Tranexamic Acid Solution for Injection 3. How Tranexamic Acid Solution for Injection is given 4. Possible side effects 5. How to store Tranexamic Acid Solution for Injection 6. Contents of the pack and other information

Tranexamic Acid 500mg/5ml Solution for Injection (called Tranexamic Acid Solution for Injection throughout the rest of this leaflet) contains tranexamic acid which belongs to a group of medicines called antihaemorragics; antifibrinolytics, aminoacids. Tranexamic acid is used in adults and children above one year of age for the prevention and treatment of bleeding due to a process that inhibits blood clotting called fibrinolysis. Specific uses include: • heavy periods in women; • gastrointestinal bleeding; • haemorrhagic urinary disorders after having an operation on your prostate gland or urinary tract; • after having an operation on your ear, nose or throat; • after having heart, abdominal or gynaecological surgery; • bleeding after you have been treated with another medicine to break down blood clots.

2. What you need to know before you are given Tranexamic Acid Solution for Injection

Do not have Tranexamic Acid Solution for Injection if you: • are allergic (hypersensitive) to tranexamic acid or any of the other ingredients of this medicine (see section 6, Other information); • currently have or have ever had a disease leading to blood clots; • have a condition called “consumption coagulopathy” where blood in the whole body starts to clot;

Tranexamic Acid Solution for Injection will be given to you by a slow injection into your vein. Your doctor will decide the correct dose for you and how long you should take it. Use in Adults • Treatment of Local Fibrinolysis: The usual dose is 500-1000mg (5-10ml) three times a day. This will usually be given by a slow injection into your vein. • Treatment of General Fibrinolysis: The usual dose is 1000mg (10ml) every 6 to 8 hours, or up to 15mg per kg of body weight. Use in Children • The doctor will decide the right dose to give your child and how long he or she should take it. • If Tranexamic Acid Solution for Injection is given to a child over one year old, the dose will be based on the child’s body weight. Use in Elderly No reduction in dose is necessary unless you have kidney problems. Use in Patients with Kidney Problems If you have problems with your kidneys, the dose may be reduced. Your doctor will decide what dose to give you based on a blood test. Use in Patients with Liver Problems No reduction in dose is necessary. Method of Administration Tranexamic Acid Solution for Injection should only be injected slowly into a vein. It should not be injected into a muscle. If you are given too much Tranexamic Acid Solution for Injection If you are given too much Tranexamic Acid Solution for Injection, you may experience temporary low blood pressure (you may feel faint or dizzy on standing). Talk to your doctor or nurse immediately.

Like all medicines, this medicine can cause side effects, although not everybody gets them. If you experience any of the following side effects after you have been given your medicine, tell your doctor immediately. If you are not in hospital, you MUST GO straight away. These side effects are rare but serious. • Severe allergic reaction which may include a red and lumpy skin rash, difficulty breathing, swelling of face, mouth, lips or eyelids, unexplained high temperature (fever) and feeling faint. If the swelling affects your throat and makes breathing and swallowing difficult, go to hospital straight away. • Symptoms of a blood clot which may include swelling or pain in your legs or chest, headache, weakness of the face and limbs on one side of the body. Other side effects which may occur: Common (may affect up to 1 in 10 users) • feeling sick; • being sick; • diarrhoea. Uncommon (may affect up to 1 in 1000 users) • rash.

Technical Leaflet intended for healthcare professionals only

Paediatrics: From one year, for the current approved indications, the dosage is in the region of 20mg/kg/day. Elderly: No reduction in dosage is necessary unless there is evidence of renal failure. Renal Failure: Due to the risk of accumulation, the dose should be reduced according to the following table:

TRANEXAMIC 500MG/5ML SOLUTION FOR INJECTION GENERAL INFORMATION Tranexamic Acid 500mg/5ml Solution for Injection is for single use only. Any portion of the vial not used at once should be discarded. THERAPEUTIC INDICATIONS Prophylaxis/treatment of haemorrhage due to general or local fibrinolysis in adults and children over one year due to: • Menorrhagia and metrorrhagia; • Gastrointestinal bleeding; • Haemorrhagic urinary disorders, following prostate surgery or procedures on the urinary tract; • Ear, nose and throat surgery; • Gynaecological or obstetric surgery; • Thoracic and abdominal surgery;

4. Possible side effects

• Haemorrhagic complications in association with thrombolytic therapy. POSOLOGY AND METHOD OF ADMINISTRATION Tranexamic Acid 500mg/5ml Solution for Injection should be administered by slow intravenous injection according to the dosage schedule below. THERAPEUTIC DOSE Adult: Local Fibrinolysis: 5-10ml (500-1000mg) by slow intravenous injection (1ml/min), three times a day. General Fibrinolysis: 10ml (1000mg) by slow intravenous injection (1ml/min), every 6 to 8 hours, equivalent to 15mg/kg body weight.

Serum Creatinine Dose iv 120-249mcmol/I 10mg/kg BW 250-500mcmol/I 10mg/kg BW >500mcmol/I 5mg/kg BW Method of administration: Slow intravenous injection only.

1. What Tranexamic Acid Solution for Injection is and what it is used for

• have kidney problems; • have a history of convulsions (fits). Due to the risk of fits or swelling in the brain, injection into the spinal cord, directly into the heart or into the brain is not recommended. If you think any of these apply to you, or if you are in any doubt at all, tell your doctor before you are given Tranexamic Acid Solution for Injection. Warnings and precautions Tell your doctor if any of the following apply to you, to help him or her decide if Tranexamic Acid Solution for Injection is suitable for you: • if you have had blood in your urine, which could indicate that there is a clot in your upper urinary tract; • if you are at risk of having blood clots; • if you suffer from excessive clotting or bleeding throughout your body (disseminated intravascular coagulation). Your doctor may carry out a blood test to see if the process that inhibits blood clotting (called fibrinolysis) is activated; • if you have had convulsions (fits). Your doctor will use the minimum dose possible to avoid further convulsions after the treatment; • if you are on long term treatment with Tranexamic Acid Solution for Injection pay attention to any possible disturbances in your colour vision. If necessary, your doctor may discontinue the treatment. With continuous, long term use of Tranexamic Acid Solution for Injection regular eye tests are recommended. If changes are seen in your eyes, your doctor may consult an eye specialist in order to decide whether to continue your treatment. Other medicines and Tranexamic Acid Solution for Injection Please tell your doctor or nurse if you are taking, or have recently taken, or might take any other medicines, including medicines obtained without a prescription. You should specifically tell your doctor if you take: • Other medicines that help blood to clot, called antifibrinolytic medicines; • Medicines that prevent blood clotting, called thrombolytic medicines; • Oral contraceptives. Pregnancy, breast-feeding and fertility • Ask your doctor for advice if you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby. • Tranexamic acid is excreted in breast milk. Therefore, the use of Tranexamic Acid Solution for Injection during breast-feeding is not recommended. Driving and using machines No studies have been performed on the ability to drive and use machines.

Read all of this leaflet carefully before you, or your child, are given this medicine because it contains important information for you.

Dose Frequency every 12 hours every 24 hours every 24 hours

Unknown (the frequency cannot be estimated from the available data) • low blood pressure (you may feel generally unwell, faint or dizzy on standing) which is usually caused by an injection being given too quickly; • fits; • visual disturbances, including colour disturbance. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or nurse. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. mhra. co. uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.

5. How to store Tranexamic Acid Solution for Injection Do not store above 25°C. Store in the original packaging. Do not refrigerate or freeze. Tranexamic Acid Solution for Injection will be stored by your doctor, nurse or pharmacist, out of the sight and reach of children. Tranexamic Acid Solution for Injection should not be used after the expiry date stated on the carton and vial label. The expiry date refers to the last day of that month. This product is for single use only. Once your doctor or nurse has opened the vial, it should be used immediately. Any remaining Tranexamic Acid Solution for Injection must be thrown away by the doctor or nurse.

6. Contents of the pack and other information

What Tranexamic Acid Solution for Injection contains - The active substance is tranexamic acid. Each 5ml vial contains 500mg tranexamic acid (100mg per ml). - The other ingredient is water for injections. What Tranexamic Acid Solution for Injection looks like and contents of the pack This medicine is a clear, colourless solution in a clear, glass vial. Each vial contains 5ml of medicine. This product is available in cartons containing 10 x 5ml vials. Marketing Authorisation Holder Focus Pharmaceuticals Limited, Capital House, 1st Floor, 85 King William Street, London EC4N 7BL, UK. Tel: 00 44 1283 495 280 Fax: 00 44 1283 495 290 Email: medinfo@focuspharma. co. uk Manufacturer Medochemie Ltd, Ampoule Injectable Facility, 48 Lapetou Street, Avios Athanasios Industrial Estate, 4101, Limassol, Cyprus. For any information about this medicinal product, please contact the Marketing Authorisation Holder, details provided above. Other sources of information

For information in large print, audio CD or Braille please telephone 00 44 (0)1283 495 280 or email medinfo@focuspharma. co. uk. This leaflet was last revised in 06/2015.

Each ampoule may contain more than the stated 5ml of liquid. This is to ensure that the full 5ml amount is available. Only 5ml should be withdrawn from the ampoule for administration to the patient. Any portion of the ampoule not used at once should be discarded. STORAGE AND DISPOSAL OF TRANEXAMIC ACID SOLUTION FOR INJECTION Do not store above 25°C. Store in the original packaging. Do not refrigerate or freeze. The product should be used immediately after opening. Any unused product or waste material should be disposed of in accordance with local requirements. Shelf life: Unopened: 30 months

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



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HOW WILL I GET depo-subQ provera 104?

depo-subQ provera 104 is given as a shot just under the skin on your thigh or belly. You get it once every 3 months.

Your healthcare provider will want to be sure that you are not pregnant before you get your first shot. Normally, you get the shot by the 5 th day from the START of your menstrual period. You get it whether or not you are still bleeding.

If you are breast-feeding, you may have your first shot as early as 6 weeks after you deliver your baby.

After the first shot

It is very important to keep getting depo-subQ provera 104 every 3 months. If you wait more than 14 weeks between shots, you could become pregnant. Your healthcare provider must make sure you are not pregnant before you get your next shot.

When you get your shot, make an appointment for your next shot. Mark it on your calendar.

WHAT IF I MISS A SHOT?

· If you miss a shot, or wait longer than 14 weeks between shots, you could get pregnant. The longer you wait, the greater the risk of getting pregnant.

· Talk with your healthcare provider to find out when to restart depo-subQ provera 104. You should be tested to be sure you are not pregnant.

· Use another kind of nonhormonal birth control, such as condoms, until you start depo-subQ provera 104 again.

DO NOT TAKE depo-subQ provera 104 IF YOUÖ

· Are pregnant or might be pregnant

· Have any unexplained vaginal bleeding

· Ever had serious blood clots, such as blood clots in your legs (deep venous thrombophlebitis), lungs (pulmonary embolism), heart (heart attack), or head (stroke)

· Have liver disease

· Are allergic to anything in depo-subQ provera 104. (There is a list of what is in depo-subQ provera 104 at the end of this leaflet.)

BEFORE TAKING depo-subQ provera 104

Your healthcare provider may do a physical examination and check your blood and urine .

Tell your healthcare provider about all your medical conditions.

Most important, tell your healthcare provider if you:

· Are pregnant or might be pregnant. You should not get depo-subQ provera 104 if you are pregnant.

· Plan to become pregnant in the next year. After you stop getting depo-subQ provera 104, it takes time for your body to be able to get pregnant. It can be as early as 1 week after the last shot wears off. Most likely it will take up to 1 year or longer for you to get pregnant.

· Have breast cancer in your family

· Have an abnormal mammogram (breast X-ray), lumps in your breast, or bleeding from your nipples

· Have irregular, light, or heavy menstrual periods

· Have or had any of the following medical problems:

- High blood pressure

- Diabetes, or if it runs in your family

- Heart attack, stroke, or developed blood clots

- Anorexia nervosa (an eating disorder)

- A strong family history of osteoporosis

- Drug use that can lower the amount of calcium in bones (drugs for epilepsy or steroids)

- Drinking a lot of alcohol or smoking a lot

It is important to see your healthcare provider regularly if you have any of these conditions.

Tell your healthcare provider about all the medicines you take. This includes prescription and over-the-counter medicines, vitamins, and herbal products.

WHAT ELSE SHOULD I KNOW ABOUT TAKING depo-subQ provera 104?

Other Birth Control. If you canít take birth control pills or canít use a birth control patch or ring, you may be able to use depo-subQ provera 104. Ask your healthcare provider.

Pregnancy. When you take depo-subQ provera 104 every 3 months, your chance of getting pregnant is very low. You could miss a period or have a light period and not be pregnant. If you miss 1 or 2 periods and think you might be pregnant, see your healthcare provider as soon as possible.

You should not use depo-subQ provera 104 if you are pregnant. However, depo-subQ provera 104 taken by accident during pregnancy does not seem to cause birth defects.

Pregnancy in your tubes (Ectopic Pregnancy). If you have severe pain low in your belly, tell your healthcare provider right away. Infrequently, a baby may start to grow outside the uterus, most often in the tubes.

Nursing a baby. Wait at least 6 weeks after your baby is born to start depo-subQ provera 104. You can use depo-subQ provera 104 if you are nursing.

· It does not lower the amount of milk you can make.

· It can pass through breast milk into your baby, but it is not harmful.

Blood or urine tests. depo-subQ provera 104 may affect blood or urine test results. Tell your healthcare provider you are taking depo-subQ provera 104 if you are going to have blood or urine tests.

Other medicines. depo-subQ provera 104 may not work as well if you are also taking Cytadren (aminoglutethimide), a cancer medicine. You may need to use another kind of birth control.

WHAT ARE COMMON SIDE EFFECTS OF depo-subQ provera 104? The most common side effects are:

· Changes in your monthly periods. You may not know when you will bleed, your periods may not be regular, you may have heavy bleeding, or you may have spotting. You may have more days of bleeding during the first 2 or 3 months after you start depo-subQ provera 104. Over time, you may have less and less bleeding. Many women stop having periods by the end of one year. Your periods will come back eventually after you stop using depo-subQ provera 104.

· Weight gain. In studies, women gained an average of 3 to 4 pounds during the first year they used depo-subQ provera 104. After 2 years of using depo-subQ provera 104, women gained an average of 7 to 8 pounds. Some women gained more, some gained less, some lost, and some stayed the same. Weight changes beyond 2 years of use with depo-subQ provera 104 have not been studied. Women who used a similar birth control product for 5 years gained on average 5 pounds more than women who did not use a hormone contraceptive product.

· Skin reaction where you got the shot. Lumps, skin dimpling, or pain are usually mild and usually donít last long. Scarring is unusual, but may happen. If there is swelling or your skin gets hot, has pus or looks bruised one or more days after your shot, call your healthcare provider.

Other less common side effects include abdominal pain, acne, breast tenderness, depression, lack of energy, irritability, and decrease in sex drive.

If you feel you are having other side effects, talk with your healthcare provider.

WHAT ARE THE MOST SERIOUS RISKS OF depo-subQ provera 104?

· Losing calcium from your bones . depo-subQ provera 104 use may decrease the amount of calcium in your bones. The longer you use depo-subQ provera 104, the more calcium you are likely to lose. This increases the risk of your bones weakening if you use depo-subQ provera 104 continuously for a long time (for example, if you use depo-subQ provera 104 for more than two years). The loss of calcium may increase your risk of osteoporosis and broken bones, particularly after your menopause.

Calcium is generally added to the bones during teenage years. The decrease of calcium in your bones is of most concern if you are a teenager or have the following risk factors:

- Anorexia nervosa (an eating disorder)

- A strong family history of osteoporosis

- Drug use that can lower the amount of calcium in bones (drugs for epilepsy or steroids), or

- Drinking a lot of alcohol or smoking a lot

If you need a birth control method for more than two years, your healthcare provider may ask you to switch to another birth control method or ask you to have a test of your bones before continuing depo-subQ provera 104, especially if you have other risks for weak bones. When depo-subQ provera 104 is stopped, the calcium in your bones begins to come back. The lost calcium may not return completely once you stop using depo-subQ provera 104. Your healthcare provider may tell you to take calcium and Vitamin D as this may lessen the loss of calcium from your bones.

· Abnormal or very heavy bleeding. If you start having very heavy or very long periods, tell your healthcare provider .

· Liver problems. Your healthcare provider may stop depo-subQ provera 104 if you have liver problems. Some signs of liver problems are yellow skin or eyes, feeling like you have the flu, feeling more tired than usual, and itching. Tell your healthcare provider if you have these symptoms.

· Allergic reaction. Allergic reactions to depo-subQ provera 104 are not common. If you have hives, problems breathing, or just do not feel right after your shot, call your healthcare provider or go to the Emergency Room right away.

· Serious blood clots. Call your healthcare provider immediately if you:

- Have sharp chest pain, cough blood, or suddenly have trouble breathing

- Have a sudden severe headache with vomiting, blindness or trouble talking, weakness, or numbness in an arm or leg, or get dizzy or faint

- Have swelling or severe pain in your leg

DOES depo-subQ provera 104 CAUSE CANCER?

· Birth control like depo-subQ provera 104 was studied in women for many years. In general, the risk of breast cancer slightly increased or stayed about the same as in women not using birth control like depo-subQ provera 104.

· The risk of cancer of the ovary, liver, or cervix did not change.

· There is a decreased risk of cancer of the uterus (endometrial cancer).

WHAT IF I WANT TO BECOME PREGNANT?

Plan ahead. The effect of depo-subQ provera 104 can last for a long time after you stop getting shots. Although you may be able to get pregnant quickly, it is more likely to take a year or longer after your last shot before you get pregnant.

Itís best to see your healthcare provider for a pre-pregnancy check-up. Your healthcare provider may also tell you to take a vitamin called folic acid every day if you are planning to become pregnant.

ARE THERE OTHER BENEFITS OF TAKING depo-subQ provera 104?

Yes. depo-subQ provera 104 may reduce your risk for cancer of the uterus.

GENERAL ADVICE ABOUT depo-subQ provera 104

For more information about depo-subQ provera 104, ask your healthcare provider or pharmacist. You can also visit www. Depo-Provera. com or call 1-866-554 DEPO (3376). A nurse can answer questions in Spanish or English 24 hours-a-day, 7 days a week.

WHAT IS IN depo-subQ provera 104?

Active ingredient: medroxyprogesterone acetate

Inactive ingredients: methylparaben, propylparaben, sodium chloride, polyethylene glycol, polysorbate 80, monobasic sodium phosphate×H 2 O, dibasic sodium phosphate×12H2O, methionine, povidone, water

for shot. When necessary, the pH is adjusted with sodium hydroxide or hydrochloric acid, or both.

Distributed by Pharmacia and Upjohn Co, Division of Pfizer Inc, NY, NY 10017

Perlutex Interactions

No drug-drug interaction studies have been conducted with depo-subQ provera 104.

Aminoglutethimide administered concomitantly with depo-subQ provera 104 may significantly decrease the serum concentrations of MPA.

The pathologist should be advised of progestin therapy when relevant specimens are submitted. The physician should be informed that certain endocrine and liver function tests, and blood components may be affected by progestin therapy:

(a) Plasma and urinary steroid levels are decreased (e. g. progesterone, estradiol, pregnanediol, testosterone, cortisol).

(b) Plasma and urinary gonadotropin levels are decreased (e. g. LH, FSH).

(c) SHBG concentrations are decreased.

(d) T 3 - uptake values may decrease.

(e) There may be small changes in coagulation factors.

(f) Sulfobromophthalein and other liver function test values may be increased slightly.

(g) There may be small changes in lipid profiles.

Perlutex Contraindications

Known or suspected pregnancy.

Undiagnosed vaginal bleeding.

Known or suspected malignancy of breast.

Active thrombophlebitis, or current or past history of thromboembolic disorders, or cerebral vascular disease.

Significant liver disease.

Known hypersensitivity to medroxyprogesterone acetate or any of its other ingredients.

Additional information about Perlutex

Perlutex Indication: Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions. Mechanism Of Action: Progestins diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge. Drug Interactions: Amobarbital The enzyme inducer decreases the effect of hormones Aprobarbital The enzyme inducer decreases the effect of hormones Bosentan Bosentan decreases the effect of contraceptive Butabarbital The enzyme inducer decreases the effect of hormones Butalbital The enzyme inducer decreases the effect of hormones Butethal The enzyme inducer decreases the effect of hormones Ethotoin The enzyme inducer decreases the effect of hormones Fosphenytoin The enzyme inducer decreases the effect of hormones Mephenytoin The enzyme inducer decreases the effect of hormones Phenytoin The enzyme inducer decreases the effect of hormones Griseofulvin The enzyme inducer decreases the effect of hormones Heptabarbital The enzyme inducer decreases the effect of hormones Hexobarbital The enzyme inducer decreases the effect of hormones Methohexital The enzyme inducer decreases the effect of hormones Methylphenobarbital The enzyme inducer decreases the effect of hormones Pentobarbital The enzyme inducer decreases the effect of hormones Phenobarbital The enzyme inducer decreases the effect of hormones Primidone The enzyme inducer decreases the effect of hormones Secobarbital The enzyme inducer decreases the effect of hormones Talbutal The enzyme inducer decreases the effect of hormones Warfarin The agent increases the effect of anticoagulant Acenocoumarol The agent increases the effect of anticoagulant Dicumarol The agent increases the effect of anticoagulant Anisindione The agent increases the effect of anticoagulant Food Interactions: Take with food. Generic Name: Medroxyprogesterone Synonyms: Medroxyprogesteronum [Inn-Latin]; Medroxyprogesteron acetate; Medroxyprogesteron; Medroxiprogesteronum; Medroxiprogesterona [Inn-Spanish]; Medrossiprogesterone [Dcit]; Medroprogesterone Acetate; MAP; Hydroxymethylprogesterone Drug Category: Contraceptives; Progestins Drug Type: Small Molecule; Approved; Investigational Other Brand Names containing Medroxyprogesterone: Aragest; Aragest 5; Asconale; Clinofem; Clinovir; Colirest; DMPA; Depo-Clinovir; Depo-Prodasone; Depo-Progestin; Depo-Promone; Depot-Medroxyprogesterone acetate; Farlutal; Farlutin; G-Farlutal; Gestapuran; Hematrol; Hysron; Indivina; Lunelle; Lutopolar; Lutoral; Med-Pro; Meprate; Metigestrona; MPA Gyn 5; Nadigest; Nidaxin; Novo-Medrone; Oragest; Perlutex; Perlutex Leo; Prodasone; Progestalfa; Progevera; Proverone; Ralovera; Repromap; Repromix; Sirprogen; Sodelut G; Veramix; Absorption: Rapidly absorbed from GI tract Toxicity (Overdose): Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders. Protein Binding: 90% Biotransformation: Hepatic Half Life: 50 days Dosage Forms of Perlutex: Tablet Oral Suspension Intramuscular Chemical IUPAC Name: (6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one Chemical Formula: C22H32O3 Medroxyprogesterone on Wikipedia: http://en. wikipedia. org/wiki/Medroxyprogesterone Organisms Affected: Humans and other mammals



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Simlo Side Effects, Price, Pharmacology - Alternatives, Simlo

SIMLO

Package Tablet Qty/Strength/Unit 10 mg Price

Possible Side Effects of SIMLO

Abdominal discomfort

Abdominal pain

Abnormal liver function tests

Activation of peptic ulcer

Arrhythmias

Blurred vision

Constipation

Diarrhoea

Dizziness

Dyspepsia

Fatigue

Flatulence

Flushing

Headache

Heart burn

Hepatic impairment

Hypotension

Myopathy

Nausea

Pruritus

Rash

Rashes

Upper respiratory tract infections

Vomiting

Home Delivery for SIMLO in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including simlo.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for simlo and other medicines and health products. Home delivery services for simlo may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take simlo only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for simlo before they complete the sale. You can get this information while placing the order for simlo with the pharmacy.

If the pharmacy that's willing to deliver medicines to your home doesn't have simlo in stock, you can ask for one of the alternative medicines for simlo. Alternatively, you can ask the pharmacist to recommend good options for the Simvastatin + Nicotinic acid generic medicine (which is what simlo essentially is).

Recently Added Pharmacies

Important Links:

Ministry of Health & Family Welfare-Government of India Department of Health Research (DHR), Government of India Department of Indian Systems of Medicine and Homoeopathy Pharmacopoeial Laboratory for Indian Medicine (PLIM) Medicine Information Centre



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Interactions Between Cezin Oral And Polyvalent-Cations-Eltrombopag, Cezin

Interactions

Eltrombopag/Polyvalent Cations

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e. g. doctor or pharmacist) for more information.

How the interaction occurs:

Medicines containing aluminum, calcium, iron, magnesium, selenium, and zinc may bind to eltrombopag in your digestive tract.

What might happen:

Your body may not absorb as much eltrombopag and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e. g. doctor or pharmacist) know that you are taking these medicines together. Time your medicines so that you do not take your eltrombopag within four hours of any medicine containing aluminum, calcium, iron, magnesium, selenium, or zinc. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Promacta (eltrombopag) US prescribing information. GlaxoSmithKline April, 2014.

2.Williams DD, Peng B, Bailey CK, Wire MB, Deng Y, Park JW, Collins DA, Kapsi SG, Jenkins JM. Effects of food and antacids on the pharmacokinetics of eltrombopag in healthy adult subjects: two single-dose, open-label, randomized-sequence, crossover studies. Clin Ther 2009 Apr;31(4):764-76.



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Dermovan Topical Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Dermoban

Dermovan topical

Uses

This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e. g. diaper rash. skin burns from radiation therapy ). Emollients are substances that soften and moisturize the skin and decrease itching and flaking. Some products (e. g. zinc oxide, white petrolatum) are used mostly to protect the skin against irritation (e. g. from wetness).

Dry skin is caused by a loss of water in the upper layer of the skin. Emollients/moisturizers work by forming an oily layer on the top of the skin that traps water in the skin. Petrolatum, lanolin. mineral oil and dimethicone are common emollients. Humectants, including glycerin. lecithin, and propylene glycol, draw water into the outer layer of skin. Many products also have ingredients that soften the horny substance (keratin) that holds the top layer of skin cells together (e. g. urea, alpha hydroxy acids such as lactic/citric/glycolic acid, and allantoin ). This helps the dead skin cells fall off, helps the skin keep in more water, and leaves the skin feeling smoother and softer.

How to use Dermovan topical

Use this product as directed. Some products require priming before use. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

Some products need to be shaken before use. Check the label to see if you should shake the bottle well before using. Apply to the affected areas of the skin as needed or as directed on the label or by your doctor. How often you apply the medication will depend on the product and your skin condition. To treat dry hands, you may need to use the product every time you wash your hands. applying it throughout the day.

If you are using this product to help treat diaper rash. clean the diaper area well before use and allow the area to dry before applying the product.

If you are using this product to help treat radiation skin burns, check with radiation personnel to see if your brand can be applied before radiation therapy.

Follow all the directions on the label for proper use. Apply to the skin only. Avoid sensitive areas such as your eyes. inside your mouth /nose, and the vaginal/groin area, unless the label or your doctor directs you otherwise. Check the label for directions about any areas or types of skin where you should not apply the product (e. g. on the face, any areas of broken/chapped/cut/irritated/scraped skin, or on a recently shaved area of the skin). Consult your doctor or pharmacist for more details.

Use this medication regularly to get the most benefit from it. Most moisturizers need water to work well. Apply the product after bathing/showering while the skin is still damp. For very dry skin. your doctor may instruct you to soak the area before using the product. Long, hot, or frequent bathing/washing can worsen dry skin .

If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

Side Effects

Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

If your doctor has prescribed this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: unusual changes in the skin (e. g. turning white/soft/soggy from too much wetness), signs of skin infection.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching/swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using this product, tell your doctor or pharmacist if you are allergic to any of the ingredients in the product; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

If you have any of the following health problems, consult your doctor or pharmacist before using this product: skin cuts/infections/sores.

Some ingredients (e. g. preservatives, fragrance) may make you more sensitive to the sun. Check the label for any warnings or ask your doctor or pharmacist if you need to take any special precautions when in the sun. Your doctor/pharmacist may suggest using a sunscreen. wearing protective clothing when outdoors, and avoiding prolonged sun exposure, tanning booths, and sunlamps.

Some products may worsen acne. If your skin is prone to acne breakouts, look for the word "non-comedogenic" (will not clog pores) on the label. Some products may stain/discolor clothing. Ask your doctor or pharmacist for more details.

It is not known whether this drug passes into breast milk. Consult your doctor before breast - feeding, especially if you are applying this product to the breast area.

Interactions

If you are using this product under your doctor's direction, your doctor or pharmacist may already be aware of possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

If your doctor has directed you to use this product, or if you use any prescription product on the skin, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, including other skin care products .

Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Some ways to help prevent dry skin include using lukewarm (not hot) water when bathing, taking baths/showers less often (e. g. every 1-2 days), keeping baths/showers short, and using a humidifier when the air is very dry.

There are many types of emollient products available. Some contain fragrance or other ingredients that some people may be sensitive to. Emollients are available in different forms such as oils, creams, lotions, or sprays. Consult with your doctor or pharmacist on the product that may be best for you.

Missed Dose

If you are using this product on a regular schedule and miss a dose, use it as soon as you remember. Do not use more product or use it more often than directed to catch up.

Storage

Refer to storage information printed on the package. If you have any questions about storage, ask your pharmacist. Keep all drug products away from children and pets.

Do not store the foam canister near high heat (more than 120 degrees F/49 degrees C), and do not store or use it near an open flame. Because foam canisters are under pressure, do not puncture or burn the canister.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

Images

No data available at this time.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Paseo - Definition Of Paseo By The Free Dictionary, Pasetocin

paseo

ambulatory - a covered walkway (as in a cloister); "it has an ambulatory and seven chapels"

boardwalk - a walkway made of wooden boards; usually at seaside

catwalk - narrow pathway high in the air (as above a stage or between parts of a building or along a bridge)

flagging - a walk of flagstones; "the flagging in the garden was quite imaginative"

path - a way especially designed for a particular use

mall. promenade - a public area set aside as a pedestrian walk

sidewalk. pavement - walk consisting of a paved area for pedestrians; usually beside a street or roadway

skywalk - an elevated walkway between buildings (usually enclosed)

Doris Payne, now 85, pleaded guilty to stealing the ring from the jewelry store on fashionable El Paseo in Palm Desert in October of 2013.

Maruti Suzuki, an India-based automaker, has launched a limited edition of the Ertiga called the Paseo Explore in India.

FirstBank (NASDAQ-NMS:FBMI), a community bank with more than 115 locations in California, Colorado, and Arizona, has said that it has completed the acquisition of El Paseo Bank's 'Market Place' branch, located at 39580 Washington St.

At KW Luxury Homes by Keller Williams on El Paseo. Luyties joins Balog to provide specialized, personal service the unique niche market that is typical of the clients Balog's Lifestyle Estate Collection[R] team attracts.

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After a mind-clearing dip in the pool, it's a sunset walk to downtown Palm Desert to scope out the town's public art, beginning with freshly installed sculptures rising out of the El Paseo median against a backdrop of rust-colored mountains.

The Earth Fair is sponsored by SCV Home Sweet Home, Santa Clarita School of the Performing Arts and the Paseo Club.

Though apparently quite simple, the project was complicated by the existing buildings and by the presence of train platforms under the Paseo de la Castellana.

It was in Mexico City that Alys, toward the end of 1991, would complete his first paseo. walking through the city's streets, dragging along a little magnetic dog mounted on wheels.

If Paseo del Norte is built right through the Petroglyph National Monument, claim the Navajo, it will open up a 6,700-acre real estate development named Black Ranch to ready buyers on the expanding west side of Albuquerque.

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Lovaza Dosage Guide, Lovaza

Lovaza Dosage

The information at Drugs. com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

• Assess triglyceride levels carefully before initiating therapy. Identify other causes (e. g. diabetes mellitus, hypothyroidism, medications) of high triglyceride levels and manage as appropriate [see Indications and Usage (1)]. • Patients should be placed on an appropriate lipid-lowering diet before receiving LOVAZA, and should continue this diet during treatment with LOVAZA. In clinical studies, LOVAZA was administered with meals.

The daily dose of LOVAZA is 4 grams per day. The daily dose may be taken as a single 4-gram dose (4 capsules) or as two 2-gram doses (2 capsules given twice daily).

Patients should be advised to swallow LOVAZA capsules whole. Do not break open, crush, dissolve, or chew LOVAZA.



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Arthricare For Women Topical Advanced Patient Information, Arthricare

Arthricare For Women (Topical)

Arthricare For Women

Capsagel

Capsagesic-HP Arthritis Relief

Capsin

Double Cap

Icy Hot Arthritis Therapy

Pain Enz

Rid-A-Pain

Sportsmed

Therapatch Warm

Trixaicin

Zostrix

Available Dosage Forms:

Therapeutic Class: Analgesic

Uses For Arthricare For Women

Capsaicin is used to help relieve a certain type of pain known as neuralgia (shingles). Capsaicin is also used to help relieve minor pain associated with rheumatoid arthritis or muscle sprains and strains. This medicine will not cure any of these conditions.

Neuralgia is a pain that comes from the nerves near the surface of your skin. This pain may occur after an infection with herpes zoster (shingles or postherpetic neuralgia). Capsaicin will help relieve the pain of postherpetic neuralgia, but it will not cure the condition.

This medicine is available both over-the-counter (OTC) and with your doctor's prescription.

Before Using Arthricare For Women

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of capsaicin in children. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of capsaicin in the elderly.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Heart or blood vessel problems, history of or

Hypertension (high blood pressure), unstable—Use the Qutenza™ patch with caution. May cause side effects to become worse.

Infection at application area or

Large sores, broken, or irritated skin at application area—Use with caution. May cause side effects to become worse.

Proper Use of capsaicin

This section provides information on the proper use of a number of products that contain capsaicin. It may not be specific to Arthricare For Women. Please read with care.

A nurse or other trained healthcare professional will apply the topical Qutenza™ patch to the affected area.

If you are using the topical cream, gel, lotion, or ointment for neuralgia, muscle pain, or arthritis, follow the instructions on the medicine label.

Be careful not to get any of this medicine in your eyes, because it can cause severe eye irritation. If the medicine does get in your eyes, wash the eyes with water and check with your doctor right away.

If capsaicin gets on your face, scalp, or in your mouth, it may cause a burning sensation. Wash these areas with warm (not hot) soapy water.

If you are using the cream, gel, lotion, or ointment :

Do not put the medicine on wounds or irritated skin.

Apply a small amount of medicine and use your fingers to rub it in well so very little or no medicine is left on the skin.

Wash your hands with soap and water after applying the medicine to avoid getting it in your eyes or on other sensitive areas of the body.

If you are using capsaicin for arthritis in your hands, do not wash your hands for at least 30 minutes after applying it.

If a bandage is being used on the treated area, do not wrap it tightly.

Use the medicine regularly every day as directed. It may take a full 2 weeks before your pain goes away.

If your condition gets worse, or does not improve after one month, stop using the medicine and check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (cream, gel, lotion, or ointment):

For arthritis, muscle pain, or neuralgia:

Adults and teenagers—Apply regularly 3 or 4 times a day and rub in well.

Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Arthricare For Women

If you use the Qutenza™ patch :

Your doctor will check you closely for any problems or unwanted effects that may be caused by this medicine.

Your blood pressure will be measured while the patch is on your skin and after it has been removed. If you notice any change to your recommended blood pressure at home, call your doctor right away. If you have questions about this, talk to your doctor.

You may have some skin redness, burning, or a stinging sensation at the application site. Heat, humidity, bathing in warm water, or sweating may increase the burning sensation. If this irritation is severe or does not go away, call your doctor.

Your skin may be more sensitive to heat and sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

Check with your doctor right away if you have coughing, shortness of breath, or any breathing problems after the patch is removed.

Your doctor might give you oral pain medicines (e. g. opioids, narcotics) while the patch is in place and after it is removed. These medicines may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

If you use the cream, gel, lotion, or ointment :

You may have some skin redness, burning, or a stinging sensation at the application site. Although this usually disappears after the first several days, it may last 2 to 4 weeks. Heat, humidity, bathing in warm water, or sweating may increase the burning sensation. If this irritation is severe or does not go away, call your doctor.

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Erythromycin

a heart rhythm disorder;

an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);

a history of Long QT syndrome; or

if you take medicine to treat a heart rhythm disorder.

FDA pregnancy category B. Erythromycin is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Erythromycin can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give this medicine to a child without a doctor's advice.

How should I take erythromycin?

Take erythromycin exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

If a child is using this medicine, tell your doctor if the child has any changes in weight. Erythromycin doses are based on weight in children.

Do not crush, chew, or break a delayed-release capsule or tablet . Swallow it whole.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Erythromycin will not treat a viral infection such as the common cold or flu.

This medicine can cause unusual results with certain lab tests of the urine. Tell any doctor who treats you that you are using erythromycin.

Store at room temperature away from moisture, heat, and light.

You may need to store liquid medicine in a refrigerator. Carefully follow the storage directions on your medicine label. Liquid medicine expires after a short period of time. Throw away any unused liquid as directed.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking erythromycin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking erythromycin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Erythromycin side effects

Get emergency medical help if you have any of these signs of an allergic reaction to erythromycin . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

diarrhea that is watery or bloody;

headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

hearing problems (rare);

liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Older adults may be more likely to have serious side effects from erythromycin, including hearing loss, or a life-threatening fast heart rate.

Common erythromycin side effects may include:

mild diarrhea; or

nausea, vomiting, stomach pain, loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Erythromycin dosing information

Usual Adult Dose of Erythromycin for Campylobacter Gastroenteritis:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose of Erythromycin for Chancroid:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Lymphogranuloma Venereum:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Mycoplasma Pneumonia:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose of Erythromycin for Nongonococcal Urethritis:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Otitis Media:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Pharyngitis:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Pneumonia:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Skin or Soft Tissue Infection:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Syphilis -- Early:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Upper Respiratory Tract Infection:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Bronchitis:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Chlamydia Infection:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Lyme Disease:

Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.

Severe infection: 1 to 4 g/day IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Legionella Pneumonia:

Although the dosage has not been established, clinical trials have used 1 to 4 g/day orally or IV in divided doses every 6 hours or by continuous infusion.

Usual Adult Dose for Bacterial Endocarditis Prophylaxis:

1 g (stearate) or 800 mg (ethylsuccinate) orally two hours before procedure, then one-half the amount six hours after initial dose.

Erythromycin was previously recommended by the American Heart Association for prophylaxis prior to dental, oral and upper respiratory tract procedures in at-risk, penicillin-allergic patients. It is no longer recommended because of the high incidence of gastrointestinal adverse effects and complicated pharmacokinetics of the various formulations. However, patients who have successfully received erythromycin for prophylaxis in the past may continue with this regimen if desired. Currently, clindamycin, first-generation cephalosporins (in patients who have not had an IgE-mediated anaphylactic reaction to penicillin), azithromycin or clarithromycin are drugs of choice for prophylaxis in penicillin-allergic patients undergoing oral, dental, respiratory tract or esophageal procedures.

Usual Adult Dose for Bowel Preparation:

1 g (base) orally at 1, 2, and 11 PM the day before surgery (assuming 8 a. m. surgery time); given with oral neomycin 1 g and bowel evacuants.

Usual Adult Dose for Rheumatic Fever Prophylaxis:

250 mg orally twice a day.

Erythromycin is recommended by the American Heart Association for long-term prophylaxis of streptococcal upper respiratory tract infections in the prevention of recurrences of rheumatic fever in patients allergic to penicillin and sulfonamides.

Usual Pediatric Dose for Bacterial Endocarditis Prophylaxis:

20 mg/kg (ethylsuccinate or stearate) orally two hours before procedure, then one-half the amount six hours after initial dose.

Erythromycin was previously recommended by the American Heart Association for prophylaxis prior to dental, oral and upper respiratory tract procedures in at-risk, penicillin-allergic patients. It is no longer recommended because of the high incidence of gastrointestinal adverse effects and complicated pharmacokinetics of the various formulations. However, patients who have successfully received erythromycin for prophylaxis in the past may continue with this regimen if desired. Currently, clindamycin, first-generation cephalosporins (in patients who have not had an IgE-mediated anaphylactic reaction to penicillin), azithromycin or clarithromycin are drugs of choice for prophylaxis in penicillin-allergic patients undergoing oral, dental, respiratory tract or esophageal procedures.

Usual Pediatric Dose for Bowel Preparation:

20 mg/kg (base) orally at 1, 2, and 11 PM the day before surgery (assuming 8 a. m. surgery time); given with oral neomycin and bowel evacuants.

Usual Pediatric Dose for Pneumonia:

Neonatal chlamydial conjunctivitis and pneumonia: 50 mg/kg/day orally in divided doses every 6 hours for at least 2 weeks.

Usual Pediatric Dose for Chlamydia Infection:

Neonatal chlamydial conjunctivitis and pneumonia: 50 mg/kg/day orally in divided doses every 6 hours for at least 2 weeks.

Usual Pediatric Dose for Rheumatic Fever Prophylaxis:

250 mg orally twice a day.

Erythromycin is recommended by the American Heart Association for long-term prophylaxis of streptococcal upper respiratory tract infections in the prevention of recurrences of rheumatic fever in patients allergic to penicillin and sulfonamides.

Usual Pediatric Dose for Pertussis:

40-50 mg/kg/day, orally, divided every 6 hours for 14 days; maximum dose: 2 g/day (not preferred agent for infants less than 1 month of age).

What other drugs will affect erythromycin?

Many drugs can interact with erythromycin. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with erythromycin, especially:

antiviral medicine (drugs to treat hepatitis, or HIV/AIDS);

any other antibiotic medicines;

drugs that lower cholesterol or triglycerides;

drugs to treat or prevent malaria;

drugs to treat pulmonary arterial hypertension;

heart or blood pressure medication;

medicine to prevent organ transplant rejection; or

medicine to treat depression or mental illness.

This list is not complete and many other drugs can interact with erythromycin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

More about erythromycin

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about erythromycin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use erythromycin only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 12.01. Revision Date: 2014-03-16, 11:53:48 PM.

Everything you need to know about antibiotics:

Drug Status

Availability Rx Prescription only

Pregnancy Category B No proven risk in humans

CSA Schedule N Not a controlled drug

Approval History Calendar Drug history at FDA

Erythromycin Rating

24 User Reviews 6.5 /10

Erythromycin 500 mg (erythromycin base)

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Coralen Larkos was a dal from deep in the northern forests of Amaril. [1] He became a student of the Guild of Mages in Tahrin. Faydwer. and went on to join Prince Keramore Thex and his Teir'Dal when the dragons attacked Faydwer. He later became the Arch Mage on the council of the Combine during the Dragon War. Even though his views were quite similar to the notion of superiority enforced by the now forbidden Koada'Dal. he refused to join their cause and ultimately remained loyal to the Combine.

Coralen was reluctant at first and did not want to join the Teir'Dal in the Dragon War. [2] But when he killed a dragon in the battle at Lucinia. he realized what his powers could accomplish. So he joined the war and later became Arch Mage of the Combine.

He faced the leader of the Ring of Scale army, Ithiosar the Black, near Myris'Hul. He failed to kill him but learned of the massive invasion that was awaiting the Combine. [3] His warnings were ignored and when the Ring of Scale attacked, the peoples of Norrath sought refuge in the last fortress of the Combine. Bastion. Coralen led the defense of Bastion during its seige, but ultimately gave his life in battle so that the people of the Combine could escape across the sea to Kunark. He was then raised from the dead by Ithiosar the Black, who transformed him into an undead lich who slaughtered those who had stayed behind in Bastion.

Relationships Edit

Coralen was married to Kallisa. with whom he fathered a son named Kallor. Kallisa was killed by a smoke-blackened wyvern, which irrepairably damaged Coralen's bond with his son. Instead, he took the magic student Merion under his wing, considering him to be more of a son to him than Kallor ever was.

Coralen was a very close friend to Prince Keramore Thex. Despite falling out with each other during the Dragon War. the two maintained a certain level of loyalty and benevolence towards one another. Coralen generally did not value friendships, except for the the one with Keramore. [4]

References Edit



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Is it possible for me to take Generic for Dithiazide* with other drugs? Should certain beverages, foods and other products be avoided when I take Generic for Dithiazide*? What are the possible drug interactions of Generic for Dithiazide*? How will Generic for Dithiazide* work in my body? How should Generic for Dithiazide* be taken? How to reduce the risk of Generic for Dithiazide* drug interactions and side effects?

Note

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Venlalic Xl 75 Mg Prolonged-Release Tablets, Venlalic

VENLALIC XL 75 MG PROLONGED-RELEASE TABLETS

Transcript

Package leaflet: Information for the user Venlalic® XL 37.5 mg prolonged-release tablets Venlalic® XL 75 mg prolonged-release tablets Venlalic® XL 150 mg prolonged-release tablets Venlalic® XL 225 mg prolonged-release tablets venlafaxine Read all of this leaflet carefully before you start taking this medicine. • • •

Keep this leaflet. You may need to read it again. If you have any further questions please ask your doctor or pharmacist. This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

What Venlalic XL is and what it is used for What you need to know before you take Venlalic XL How to take Venlalic XL Possible side effects How to store Venlalic XL Contents of the pack and other information

What Venlalic XL is and what it is used for

Venlalic XL is an antidepressant that belongs to a group of medicines called serotonin and norepinephrine reuptake inhibitors (SNRIs). This group of medicines is used to treat depression and other conditions such as anxiety disorders. It is thought that people who are depressed and/or anxious have lower levels of serotonin and noradrenaline in the brain. It is not fully understood how antidepressants work, but they may help by increasing the levels of serotonin and noradrenaline in the brain. Venlalic XL is a treatment for adults with depression. Venlalic XL is also a treatment for adults with the following anxiety disorders: generalised anxiety disorder, social anxiety disorder (fear or avoidance of social situations) and panic disorder (panic attacks). Treating depression or anxiety disorders properly is important to help you get better. If it is not treated, your condition may not go away and may become more serious and more difficult to treat. 2.

What you need to know before you take Venlalic XL

Do not take Venlalic XL • •

If you are allergic to venlafaxine or any of the other ingredients of this medicine (listed in section 6). If you are also taking or have taken any time within the last 14 days any medicines known as irreversible monoamine oxidase inhibitors (MAOIs), used to treat depression or Parkinson’s disease. Taking an irreversible MAOI together with Venlalic XL, can cause serious or even life-threatening side effects. Also, you must wait at least 7 days after you stop taking Venlalic XL before you take any MAOI (see also the sections entitled “Taking other medicines” and the information in that section about “Serotonin syndrome”).

Warnings and precautions Talk to your doctor before taking Venlalic XL •

If you use other medicines that taken concomitantly with Venlalic XL could increase the risk of developing serotonin syndrome (see the section “Taking other medicines”). If you have a swallowing, stomach or intestinal disorder that reduces your ability to swallow or pass foods by normal bowel movements. If you have eye problems, such as certain kinds of glaucoma (increased pressure in the eye). If you have a history of high blood pressure. If you have a history of heart problems. If you have a history of fits (seizures). If you have a history of low sodium levels in your blood (hyponatraemia). If you have a tendency to develop bruises or a tendency to bleed easily (history of bleeding disorders), or if you are

taking other medicines that may increase the risk of bleeding e. g. warfarin (used to prevent blood clots). If your cholesterol levels get higher. If you have a history of, or if someone in your family has had, mania or bipolar disorder (feeling over-excited or euphoric). If you have a history of aggressive behaviour.

Venlalic XL may cause a sensation of restlessness or an inability to sit or stand still during the first few weeks of treatment. You should tell your doctor if this happens to you. If any of these conditions apply to you, please talk with your doctor before taking Venlalic XL. Thoughts of suicide and worsening of your depression or feelings of anxiety If you are depressed and/or have anxiety disorders, you can sometimes have thoughts of harming or killing yourself. These may be increased when you first start taking antidepressants, since these medicines all take time to work, usually about two weeks, but sometimes longer. You may be more likely to think like this: • If you have previously had thoughts about killing yourself or harming yourself. • If you are a young adult. Information from clinical trials has shown an increased risk of suicidal behaviour in young

adults (less than 25 years old) with psychiatric conditions who were treated with an antidepressant. If you have thoughts of harming or killing yourself at any time, contact your doctor or go to a hospital straight away. You may find it helpful to tell a relative or close friend that you are depressed or have an anxiety disorder and ask them to read this leaflet. You might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behaviour. Dry mouth Dry mouth is reported in 10% of patients treated with venlafaxine. This may increase the risk of caries. Therefore, you should take special care in your dental hygiene. Diabetes Your blood glucose levels may be altered due to Venlalic XL. Therefore, the dosages of your diabetes medicines may need to be adjusted. Use in children and adolescents under 18 years of age Venlalic XL should normally not be used for children and adolescents under 18 years. Also, you should know that patients under 18 have an increased risk of side effects, such as suicide attempt, suicidal thoughts and hostility (predominantly aggression, oppositional behaviour and anger) when they take this class of medicines. Despite this, your doctor may prescribe this medicine for patients under 18 because he/she decides that this is in their best interests. If your doctor has prescribed Venlalic XL for a patient under 18, and you want to discuss this, please go back to your doctor. You should inform your doctor if any of the symptoms listed above develop or worsen when patients under 18 are taking Venlalic XL. Also, the long-term safety effects concerning growth, maturation and cognitive and behavioural development of Venlalic XL in this age group has not yet been demonstrated. Other medicines and Venlalic XL Tell your doctor or pharmacist if you are taking, have recently taken any other medicines. Your doctor should decide whether you can take Venlalic XL with other medicines. Do not start or stop taking any medicines, including those bought without a prescription, natural and herbal remedies, before checking with your doctor or pharmacist. • Monoamine oxidase inhibitors which are used to treat depression or Parkinson’s disease must not be taken with

Venlalic XL. Tell your doctor if you have taken these medicines within the last 14 days. (MAOIs: see the section “Before

you take Venlalic XL”). • Serotonin syndrome:

Serotonin syndrome, a potentially life-threatening condition (see the section “Possible Side Effects”), may occur with

venlafaxine treatment, particularly when taken with other medicines.

Examples of these medicines include: • Triptans (used for migraine) • Medicines to treat depression, for instance SNRI, SSRIs, tricyclics, or medicines containing lithium • Medicines containing linezolid, an antibiotic (used to treat infections) • Medicines containing moclobemide, a reversible MAOI (used to treat depression) • Medicines containing sibutramine (used for weight loss) • Medicines containing tramadol (a pain-killer) • Medicines containing methylene blue (used to treat high levels of methaemoglobin in the blood) • Products containing St. John’s Wort (also called Hypericum perforatum, a natural or herbal remedy used to treat mild depression) • Products containing tryptophan (used for problems such as sleep and depression) • Antipsychotics (used to treat a disease with symptoms such as hearing, seeing or sensing things which are not there, mistaken beliefs, unusual suspiciousness, unclear reasoning and becoming withdrawn) Signs and symptoms of serotonin syndrome may include a combination of the following: restlessness, hallucinations, loss of coordination, fast heart beat, increased body temperature, fast changes in blood pressure, overactive reflexes, diarrhoea, coma, nausea, vomiting. In its most severe form, serotonin syndrome can resemble Neuroleptic Malignant Syndrome (NMS). Signs and symptoms of NMS may include a combination of fever, fast heart beat, sweating, severe muscle stiffness, confusion, increased muscle enzymes (determined by a blood test). Tell your doctor immediately, or go to the casualty department at your nearest hospital if you think serotonin syndrome is happening to you The following medicines may also interact with Venlalic XL and should be used with caution. It is especially important to mention to your doctor or pharmacist if you are taking medicines containing: • • • • •

Ketoconazole, Itraconazole, Voriconazole, Posaconazole (antifungal medicines) Clarithromycin, telithromycin (antibiotics used to treat infections) Atazanavir, indinavir, nelfinavir, ritonavir, saquinavir (used to treat HIV infection) Haloperidol or risperidone (to treat psychiatric conditions) Metoprolol (a beta blocker to treat high blood pressure and heart problems)

Venlalic XL with food, drink and alcohol Venlalic XL should be taken with food (see section 3 “How to take Venlalic XL”). You should avoid alcohol while you are taking Venlalic XL. Pregnancy, breast-feeding and fertility Tell your doctor if you become pregnant, or you are trying to become pregnant. You should use Venlalic XL only after discussing the potential benefits and the potential risks to your unborn child with your doctor. Make sure your midwife and/or doctor knows you are on Venlalic XL. When taken during pregnancy, similar drugs (SSRIs) may increase the risk of a serious condition in babies, called persistent pulmonary hypertension of the newborn (PPHN), making the baby breathe faster and appear bluish. These symptoms usually begin during the first 24 hours after the baby is born. If this happens to your baby you should contact your midwife and/or doctor immediately. If you are taking Venlalic XL during pregnancy, let your midwife and/or doctor know, as your baby might have some symptoms when it is born. These symptoms usually begin during the first 24 hours after the baby is born. They include irritability, tremor, hypotonia, constant crying, sleeping difficulties and, not feeding properly. If your baby has these symptoms when it is born and you are concerned, contact your doctor and/or midwife who will be able to advise you. Venlafaxine passes into breast milk. There is a risk of an effect on the baby, which may cause symptoms such as crying, irritabilty and abnormal sleep patterns. Symptoms consistent with venlafaxine drug discontinuation can also occur after stopping breast-feeding. Therefore, you should discuss the matter with your doctor, and he/she will decide whether you should stop breast-feeding or stop the therapy with Venlalic XL. Driving and using machines Do not drive or use any tools or machines until you know how Venlalic XL affects you. Important information about some of the ingredients of Venlalic XL This medicine contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product. 3.

How to take Venlalic XL

Always take this medicine exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. The usual recommended starting dose for treatment of depression generalised anxiety disorder and social anxiety disorder is 75 mg per day. The dose can be raised by your doctor gradually, and if needed, even up to a maximum dose of 375 mg daily for depression. If you are being treated for panic disorder, your doctor will start with a lower dose (37.5 mg) and then increase the dose gradually. The maximum dose for generalised anxiety disorder, social anxiety disorder and panic disorder is 225 mg/day. Take Venlalic XL at approximately the same time each day, either in the morning or in the evening. Tablets must be swallowed whole with fluid and not opened, crushed, chewed or dissolved. Venlalic XL should be taken with food. If you have liver or kidney problems, talk to your doctor, since your dose of Venlalic XL may need to be different. Do not stop taking Venlalic XL without talking to your doctor (see the section “If you stop taking Venlalic XL”). If you take more Venlalic XL than you should Call your doctor or pharmacist immediately if you take more than the amount of Venlalic XL prescribed by your doctor. The symptoms of a possible overdose may include a rapid heart beat, changes in level of alertness (ranging from sleepiness to coma), blurred vision, seizures or fits, and vomiting. If you forget to take Venlalic XL If you miss a dose, take it as soon as you remember. However, if it is time for your next dose, skip the missed dose and take only a single dose as usual. Do not take more than the daily amount of Venlalic XL that has been prescribed for you in one day.

If you stop taking Venlalic XL Do not stop taking your treatment or reduce the dose without the advice of your doctor even if you feel better. If your doctor thinks that you no longer need Venlalic XL, he/she may ask you to reduce your dose slowly before stopping treatment altogether. Side effects are known to occur when people stop using Venlalic XL, especially when Venlalic XL is stopped suddenly or the dose is reduced too quickly. Some patients may experience symptoms such as tiredness, dizziness, lightheadedness, headache, sleeplessness, sensation that everything around you is spinning or moving (vertigo), nightmares, dry mouth, loss of appetite, nausea, diarrhoea, nervousness, agitation, confusion, ringing in the ears, tingling or rarely electric shock sensations, weakness, sweating, seizures, or flu-like symptoms. Your doctor will advise you on how you should gradually discontinue Venlalic XL treatment. If you experience any of these or other symptoms that are troublesome, ask your doctor for further advice. If you have any further questions on the use of this product, ask your doctor or pharmacist. 4.

Possible side effects

Like all medicines, Venlalic XL can cause side effects, although not everybody gets them. Do not be concerned if you see a tablet in your stools after taking Venlalic XL. As the tablet travels the length of your gastrointestinal tract, venlafaxine is slowly released. The shape of the tablet remains undissolved and is eliminated in your stools. Therefore, even though you may see a tablet in your stools, your dose of venlafaxine has been absorbed. Allergic reactions If any of the following happen, do not take more Venlalic XL. Tell your doctor immediately, or go to the casualty department at your nearest hospital: • • • • •

Chest tightness, wheezing, trouble swallowing or breathing Swelling of the face, throat, hands, or feet Feeling nervous or anxious, dizziness, throbbing sensations, sudden reddening of the skin and/or a warm feeling Severe rash, itching, or hives (elevated patches of red or pale skin that often itch) Signs and symptoms of serotonin syndrome which may include restlessness, hallucinations, loss of coordination, fast heart beat, increased body temperature, fast changes in blood pressure, overactive reflexes, diarrhoea, coma, nausea, vomiting.

In its most severe form, serotonin syndrome can resemble Neuroleptic Malignant Syndrome (NMS). Signs and symptoms of NMS may include a combination of fever, fast heart beat, sweating, severe muscle stiffness, confusion, increased muscle enzymes (determined by a blood test). Other side effects that you should tell your doctor about include: • • • • • • • • •

Coughing, wheezing, shortness of breath and a high temperature Black (tarry) stools or blood in stools Yellow skin or eyes, itchiness or dark urine, which may be symptoms of inflammation of the liver (hepatitis) Heart problems, such as fast or irregular heart rate, increased blood pressure Eye problems, such as blurred vision, dilated pupils Nerve problems, such as dizziness, pins and needles, movement disorder, seizures or fits Psychiatric problems, such as hyperactivity and euphoria (feeling unusually overexcited) Withdrawal effects (see the section “How to take Venlalic XL, if you stop taking Venlalic XL”) Prolonged bleeding - if you cut or injure yourself, it may take slightly longer than usual for bleeding to stop

Complete side effect listing Very common (may affect more than 1 in 10 people) • • •

Dizziness; headache Nausea; dry mouth Sweating (including night sweats)

Common (may affect up to 1 in 10 people) • •

Appetite decreased Confusion; feeling separated (or detached) from yourself; lack of orgasm; decreased libido; nervousness; insomnia; abnormal dreams Drowsiness; tremor; pins and needles; increased muscle tonus Visual disturbance including blurred vision; dilated pupils; inability of the eye to automatically change focus from distant to near objects Ringing in the ears (tinnitus) Palpitations Increase in blood pressure; flushing Yawning Vomiting; constipation; diarrhoea Increased frequency in urination; difficulties passing urine Menstrual irregularities such as increased bleeding or increased irregular bleeding; abnormal ejaculation/orgasm (males); erectile dysfunction (impotence) Weakness (asthenia); fatigue; chills Increased cholesterol

Uncommon (may affect up to 1 in 100 people) •

Hallucinations; feeling separated (or detached) from reality; agitation; abnormal orgasm (females); lack of feeling or

emotion; feeling over-excited; grinding of the teeth A sensation of restlessness or an inability to sit or stand still; fainting; involuntary movements of the muscles; impaired coordination and balance; altered taste sensation Fast heart beat; feeling dizzy (particularly when standing up too quickly) Vomiting blood, black tarry stools (faeces) or blood in stools; which can be a sign of internal bleeding General swelling of the skin especially the face, mouth, tongue, throat area or hands and feet and/or a raised itchy rash (hives) may be present; sensitivity to sunlight; bruising; rash; abnormal hair loss Inability to pass urine Weight gain; weight loss

Rare (may affect up to 1 in 1,000 people) • • •

Seizures or fits Inability to control urination Over activity, racing thoughts and decreased need for sleep (mania)

Not known (frequency cannot be estimated from the available data) •

Reduced number of platelets in your blood, leading to an increased risk of bruising or bleeding; blood disorders which may lead to an increased risk of infection Swollen face or tongue, shortness of breath or difficulty breathing, often with skin rashes (this may be a serious allergic reaction) Excessive water intake (known as SIADH) Decrease in blood sodium levels Suicidal ideation and suicidal behaviours; cases of suicidal ideation and suicidal behaviours have been reported during venlafaxine therapy or early after treatment discontinuation (see section 2, Before you take Venlalic XL) Disorientation and confusion often accompanied by hallucination (delirium); aggression A high temperature with rigid muscles, confusion or agitation, and sweating, or if you experience jerky muscle

movements which you can’t control, these may be symptoms of serious conditions known as neuroleptic malignant syndrome; euphoric feelings, drowsiness, sustained rapid eye movement, clumsiness, restlessness, feeling of being drunk, sweating or rigid muscles, which are symptoms of serotonin syndrome; stiffness, spasms and involuntary movements of the muscles Severe eye pain and decreased or blurred vision Vertigo Decrease in blood pressure; abnormal, rapid or irregular heart beat, which could lead to fainting; unexpected bleeding, e. g. bleeding gums, blood in the urine or in vomit, or the appearance of unexpected bruises or broken blood vessels (broken veins) Coughing, wheezing, shortness of breath and a high temperature, which are symptoms of inflammation of the lungs associated with an increase in white blood cells (pulmonary eosinophilia) Severe abdominal or back pains (which could indicate a serious problem in the gut, liver or pancreas) Itchiness, yellow skin or eyes, dark urine, or flu-like symptoms, which are symptoms of inflammation of the liver

(hepatitis); slight changes in blood levels of liver enzymes Skin rash, which may lead to severe blistering and peeling of the skin; itching; mild rash Unexplained muscle pain, tenderness or weakness (rhabdomyolysis) Abnormal breast milk production

Venlalic XL sometimes causes unwanted effects that you may not be aware of, such as increases in blood pressure or abnormal heart beat; slight changes in blood levels or liver enzymes, sodium or cholesterol. More rarely, Venlalic XL may reduce the function of platelets in your blood, leading to an increased risk of bruising or bleeding. Therefore, your doctor may wish to do blood tests occasionally, particularly if you have been taking Venlalic XL for a long time. If you get any of the side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. 5.

How to store Venlalic XL

Keep out of the reach and sight of children. Do not use Venlalic XL after the expiry date which is stated on the packaging. The expiry date refers to the last day of that month. Store below 30?C. Blisters: Store in the original package in order to protect from moisture. Plastic bottle: Keep the bottle tightly closed in order to protect from moisture. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment. 6.

Contents of the pack and other information

What Venlalic XL contains The active substance is venlafaxine. Each prolonged-release tablet contains 37.5, 75, 150 or 225 mg venlafaxine (as hydrochloride). The other ingredients are Core: Mannitol (E421), Povidone K-90, Macrogol 400, Cellulose microcrystalline, Colloidal anhydrous silica, Magnesium stearate. Coat: Cellulose acetate, Macrogol 400, hypromellose, lactose monohydrate, titanium dioxide (E171), triacetin. What Venlalic XL looks like and contents of the pack 37.5 mg prolonged-release tablets: 75 mg prolonged-release tablets: 150 mg prolonged-release tablets: 225 mg prolonged-release tablets:

7 mm round, biconvex, white tablets. 7.5 mm round, biconvex, white tablets. 9.5 mm round, biconvex, white tablets. 11 mm round, biconvex, white tablets.

Venlalic XL is available in blisters of 10, 14, 20, 28, 30, 50, 56, 60, 100 and 500 tablets; and in plastic bottles of 10, 14, 20, 28, 30, 50, 56, 60, 100 and 500 tablets. Not all pack sizes may be marketed. Marketing Authorisation Holder and Manufacturer Marketing authorisation holder:

DB Ashbourne Ltd The Rectory, Braybrooke Road Arthingworth, Market Harborough LE16 8JT, United Kingdom



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Benadryl is an antihistamine. Diphenhydramine blocks the effects of the naturally occurring chemical histamine in the body. It is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; and other symptoms of allergies and the common cold.

Availability: In Stock (14 packs)

Analogs of: Benadryl

Other names of Benadryl:

Benadryl is used for preventing or treating symptoms of hay fever and other upper respiratory allergies or the common cold, such as runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes, and relieving cough.

Do not take Benadryl if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

Before taking Benadryl, tell your doctor if you have:

glaucoma or increased pressure in the eye;

a stomach ulcer;

an enlarged prostate, bladder problems or difficulty urinating;

an overactive thyroid (hyperthyroidism);

hypertension or any type of heart problems; or

asthma.

You may not be able to take Benadryl, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Take Benadryl exactly as directed on the package or as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Benadryl can be taken with or without food.

For motion sickness, a dose is usually taken 30 minutes before motion, then with meals and at bedtime for the duration of exposure.

As a sleep aid, Benadryl should be taken approximately 30 minutes before bedtime.

To ensure that you get a correct dose, measure the liquid forms of Benadryl with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Never take more of Benadryl than is prescribed for you. The maximum amount of diphenhydramine that you should take in any 24-hour period is 300 mg.

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of Benadryl unless otherwise directed by your doctor.

Do NOT use more than directed.

Adults and children 12 years of age and over - 25 mg to 50 mg (1 to 2 capsules).

Children 6 to under 12 years of age - 12.5 mg ** to 25 mg (1 capsule).

Children under 6 years of age - consult a doctor.

Store Benadryl at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Benadryl out of the reach of children and away from pets.

Before taking diphenhydramine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (e. g. asthma, emphysema), glaucoma, heart problems, high blood pressure, liver disease, mental/mood changes, seizures, stomach problems (e. g. ulcers, obstruction), an overactive thyroid gland, difficulty urinating (e. g. due to an enlarged prostate gland).

Benadryl is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take Benadryl without first talking to your doctor if you are pregnant. Infants are especially sensitive to the effects of antihistamines, and side effects could occur in a breast-feeding baby. Do not take Benadryl without first talking to your doctor if you are nursing a baby.

If you are over 60 years of age, you may be more likely to experience side effects from Benadryl. You may require a lower dose of Benadryl.

Stop taking Benadryl and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take Benadryl and talk to your doctor if you experience:

sleepiness, fatigue, or dizziness;

headache;

dry mouth; or

difficulty urinating or an enlarged prostate.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

When using this product:

marked drowsiness may occur

avoid alcoholic drinks

alcohol, sedatives, and tranquilizers may increase drowsiness

excitability may occur, especially in children

be careful when driving a motor vehicle or operating machinery

Asthma - Dramalyn (Brand name: benadryl)

Benadryl is used for preventing or treating symptoms of hay fever and other upper respiratory allergies or the common cold, such as runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes, and relieving cough.

Do not take Benadryl if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

Before taking Benadryl, tell your doctor if you have:

glaucoma or increased pressure in the eye;

a stomach ulcer;

an enlarged prostate, bladder problems or difficulty urinating;

an overactive thyroid (hyperthyroidism);

hypertension or any type of heart problems; or

asthma.

You may not be able to take Benadryl, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Take Benadryl exactly as directed on the package or as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Benadryl can be taken with or without food.

For motion sickness, a dose is usually taken 30 minutes before motion, then with meals and at bedtime for the duration of exposure.

As a sleep aid, Benadryl should be taken approximately 30 minutes before bedtime.

To ensure that you get a correct dose, measure the liquid forms of Benadryl with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Never take more of Benadryl than is prescribed for you. The maximum amount of diphenhydramine that you should take in any 24-hour period is 300 mg.

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of Benadryl unless otherwise directed by your doctor.

Do NOT use more than directed.

Adults and children 12 years of age and over - 25 mg to 50 mg (1 to 2 capsules).

Children 6 to under 12 years of age - 12.5 mg ** to 25 mg (1 capsule).

Children under 6 years of age - consult a doctor.

Store Benadryl at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Benadryl out of the reach of children and away from pets.

Before taking diphenhydramine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (e. g. asthma, emphysema), glaucoma, heart problems, high blood pressure, liver disease, mental/mood changes, seizures, stomach problems (e. g. ulcers, obstruction), an overactive thyroid gland, difficulty urinating (e. g. due to an enlarged prostate gland).

Benadryl is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take Benadryl without first talking to your doctor if you are pregnant. Infants are especially sensitive to the effects of antihistamines, and side effects could occur in a breast-feeding baby. Do not take Benadryl without first talking to your doctor if you are nursing a baby.

If you are over 60 years of age, you may be more likely to experience side effects from Benadryl. You may require a lower dose of Benadryl.

Stop taking Benadryl and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take Benadryl and talk to your doctor if you experience:

sleepiness, fatigue, or dizziness;

headache;

dry mouth; or

difficulty urinating or an enlarged prostate.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

When using this product:

marked drowsiness may occur

avoid alcoholic drinks

alcohol, sedatives, and tranquilizers may increase drowsiness

excitability may occur, especially in children

be careful when driving a motor vehicle or operating machinery



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Sensaval, Sensaval

sensate

24,29] In the patient presented in this report, bilateral neurotized pedicled island ALT flaps were chosen because of the potential to harvest a large amount of sensate. hair-bearing skin.

Now, Kohler simplifies and streamlines time spent in the kitchen with Sensate. its new touch-less kitchen faucet launched in the UAE market.

Sensate Focus involves structured and progressive touching between two partners, advancing from initially non-genital touch through to more pleasure-oriented touch in subsequent stages.

Her point here is that happiness is not a sensate state that can be attained automatically; it requires work, just as her mother worked to attain some form of happiness just by giving birth to her.

Simultaneously, Masters and Johnson's therapeutic interventions, such as sensate focus exercises, (69) resonated with the ethic of care, later theorized by Carol Gilligan, which has become a hallmark of cultural feminism.

In his major work "Social and cultural dynamics" (2006) Sorokin links this to his own division of cultures into ideational, idealistic and sensate phases, thus transforming the three planes of time from medieval, primarily theological, categories into sociological ones.

They are concrete-minded, so abstractions have far less meaning than teachings grounded in sensate reality.

It is perfectly sensate for an organism to respond to environmental stresses with specific biological programs (the onset of fever, the regulation of the menstrual cycle, growth processes, healing of wounds, etc.

The surrounding mucosa was sensate and well vascularized.

Her subject--the imperceptible "atmospheric communication hovering over the city like a sensate cloud" or "smart dust"--is sure to change any reader's experience of urban space, perhaps even in disquieting ways (58, 50).

I know the way the struck chord begins to shudder, fierce heat rising into the skin of my own sensate palms.

Our many senses exist at remarkably different levels of development and respond to an infinite variety of settings, making us truly sensate and, hopefully, sensible beings.



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Pribalovy Letak Trittico Ac 150, Trittico Ac

Pribalovy letak TRITTICO AC 150

Humanni lecivy pripravek

TRITTICO AC 150

Tablety s rizenym uvolnovanim (Trazodoni hydrochloridum)

Prectete si pozorne cely pribalovy letak drive, nez zacnete tento pripravek uzivat.

Ponechte si pribalovy letak pro pripad, ze si jej budete potrebovat precist znovu.

Mate-li jakekoli dalsi otazky, zeptejte se sveho lekare nebo lekarnika.

Tento pripravek byl predepsan Vam. Nedavejte jej zadne dalsi osobe. Mohl by ji ublizit, a to i tehdy, ma-li stejne priznaky jako Vy.

Pokud se kterykoli z nezadoucich ucinku vyskytne v zavazne mire, nebo pokud si vsimnete jakychkoli nezadoucich ucinku, ktere nejsou uvedeny v teto pribalove informaci, prosim, sdelte to svemu lekari nebo lekarnikovi.

V pribalovem letaku naleznete:

Co je Trittico AC a k cemu se pouziva

Cemu musite venovat pozornost, nez zacnete Trittico AC uzivat

Jak se Trittico AC uziva

Mozne nezadouci ucinky

Jak Trittico AC uchovavat

Dalsi informace

1. CO JE TRITTICO AC A K CEMU SE POUZIVA

Trittico AC patri mezi antidepresiva treti generace s vyraznym pusobenim proti uzkosti, pocitum napeti, neklidu, porucham spanku a sexualnich funkci. Pripravek je velmi dobre snasen. Pro minimum nezadoucich ucinku a lekovych interakci je vhodny i pro starsi pacienty. Lekova forma s rizenym uvolnovanim umoznuje udrzovani rovnomerne hladiny lecive latky v krvi a davkovani jednou denne. Tablety lze delit na 3 casti, coz umozni pozvolne nastaveni optimalni individualni lecebne davky. Neexistuji zadne dukazy, ze by byl trazodon hydrochlorid navykovy. Pripravek Trittico AC neni kontraindikovan u osob s celiakii.

2. CEMU MUSITE VENOVAT POZORNOST, NEZ ZACNETE TRITTICO AC UZIVAT

Neuzivejte pripravek Trittico AC

jestlize jste precitlively/a na lecivou latku nebo na kteroukoliv dalsi slozku pripravku.

jestlize se u Vas v soucasne dobe projevila otrava alkoholem nebo hypnotiky.

Zvlastni opatrnosti pri pouziti pripravku Trittico AC je zapotrebi

Pri pouziti u deti a mladistvych do 18 let veku: Ackoli Trittico AC deti a dospivajici do 18 let neuzivaji bezne, muze je Vas lekar pacientum do 18 let predepsat, pokud usoudi, ze je to v jejich nejlepsim zajmu. V souvislosti s uzivanim antidepresiv pacienty do 18 let bylo pozorovano zvysene riziko vyskytu nezadoucich ucinku, jako jsou pokusy o sebevrazdu, sebevrazedne myslenky a nepratelske jednani (prevazne agresivita, nepratelske chovani a hnev). Jestlize se u pacientu do 18 let, kteri jsou leceni pripravkem Trittico AC, rozvine nebo zhorsi nektery z vyse uvedenych priznaku, informujte o tom sveho lekare. Z hlediska bezpecnosti nejsou v teto vekove skupine pri dlouhodobem podavani pripravku Trittico AC k dispozici udaje o vztahu k dalsimu rustu, dospivani, rozvoji poznani a chovani.

Pri sebevrazednych myslenkach nebo klinickem zhorseni: Protoze je deprese provazena rizikem sebevrazednych myslenek, sebeposkozeni a sebevrazd, musi byt pacienti peclive monitorovani, dokud se jejich stav vyrazne nezlepsi. Obecne znamy fakt je, ze riziko sebevrazdy muze byt vyssi v pocatecnim stadiu uzdravovani a u pacientu se sebevrazednymi pokusy v anamneze nebo u pacientu, kteri se sebevrazednymi myslenkami zabyvali ve vetsi mire jiz pred zapocetim lecby. Zlepseni stavu se nemusi projevit po prvnich tydnech lecby ci po delsi dobe, a proto je treba pacienta peclive monitorovat dlouhodobe, s durazem na dohled v pocatecnim stadiu lecby a po zmenach davkovani. Pacienti (a dohlizejici osoby) by meli v pripade zhorseni klinickeho stavu, sebevrazednych myslenek ci chovani a jinak neobvykleho chovani ihned vyhledat lekarskou pomoc.

Pri podavani pacientum se schizofrenii a dalsimi psychotickymi onemocnenimi: Podavani antidepresiv muze u techto pacientu vest i ke zhorseni psychotickych symptomu. Paranoidni myslenky mohou byt silnejsi. Behem lecby depresivni faze trazodonem se muze depresivni faze zmenit v manickou. V tomto pripade ihned kontaktujte sveho lekare.

Pri nasledujicich onemocnenich a stavech:

epilepsie (Vas lekar Vam nejspis doporuci vyhnout se nahlemu zvyseni nebo snizeni davky),

onemocneni jater nebo ledvin (zejmena pokud je onemocneni vazne). Projevi-li se u Vas zloutenka, musi byt lecba trazodonem prerusena.

onemocneni srdce jako je angina pectoris, poruchy prevodniho systemu nebo AV blok a po infarktu myokardu,

zvysena funkce stitne zlazy,

poruchy moceni, napriklad pri zvetseni prostaty (ackoliv v tomto pripade nejsou problemy predpokladany, upozornete sveho lekare, pokud se u Vas projevi),

akutni glaukom s uzavrenym uhlem nebo zvyseny nitroocni tlak (ackoliv v tomto pripade nejsou problemy predpokladany, upozornete sveho lekare, pokud se u Vas projevi).

V pripade, ze trpite nekterym z vyse uvedenych onemocneni a lekare jste o tom pred predepsanim pripravku Trittico AC neinformovali, ucinte tak dodatecne.

Pri soucasnem podavani dalsich leciv: Z duvodu predchazeni interakci a nezadoucich ucinku informujte sveho lekare o vsech lecivech, ktera uzivate, predevsim o dalsich antidepresivech, vcetne leciv rostlinneho puvodu (s obsahem trezalky teckovane – Hypericum perforatum), neurolepticich ci antihypertenzivech. Soubezne podavani techto pripravku s trazodonem muze vyzadovat upravu jejich davky. Viz kapitoly „Vzajemne pusobeni s dalsimi pripravky“ a „Nezadouci ucinky“ pro dalsi informace.

Pri ukoncovani lecby: Pri ukonceni lecby trazodonem, zejmena po dlouhodobejsi lecbe, je doporuceno postupne snizovani davky, aby se zredukovaly mozne priznaky, jako je nevolnost, bolest hlavy a malatnost.

Pri nesnasenlivosti nekterych cukru: Pripravek obsahuje sacharozu. Pokud Vam Vas lekar rekl, ze nesnasite nektere cukry, poradte se s nim, nez zacnete tento lecivy pripravek uzivat.

Vzajemne pusobeni s dalsimi lecivymi pripravky Prosim, informujte sveho lekare nebo lekarnika o vsech lecich, ktere uzivate nebo jste uzival(a) v nedavne dobe, a to i o lecich, ktere jsou dostupne bez lekarskeho predpisu.

Obecne: Uzivani pripravku Trittico AC muze zpusobit zvyseni ucinku jinych leciv s ucinkem antipsychotickym, hypnotickym, zklidnujicim, zmirnujicim stavy uzkosti a antihistaminik. Metabolizmus antidepresiv je diky ucinkum na jatra zrychlovan peroralnimi kontraceptivy, fenytoinem, karbamazepinem a barbituraty. Cimetidin a nektera antipsychotika metabolizmus antidepresiv zpomaluji.

Pokud uzivate nektery z nasledujicich pripravku, informujte o tom sveho lekare:

CYP3A4 inhibitory: Pripravky obsahujici erytromycin, ketokonazol, itrakonazol, ritonavir, indinavir a nefazodon mohou zvysit nezadouci ucinky pripravku Trittico AC. Pokud je vsak soucasne podavani nezbytne, zvazi Vas lekar upravu davkovani pripravku Trittico AC.

Karbamazepin: Soucasne podavani karbamazepinu a pripravku Trittico AC ma za nasledek nizsi plazmaticke koncentrace pripravku Trittico AC. Pokud je vsak soucasne podavani nezbytne, zvazi Vas lekar upravu davkovani.

Tricyklicka antidepresiva: Tyto pripravky by nemely byt podavany soucasne s pripravkem Trittico AC z duvodu moznych interakci. Je treba davat pozor na mozny vznik serotoninoveho syndromu (vysoka teplota, zaskuby ve svalech, zmatenost nebo neklid) a kardiovaskularnich nezadoucich ucinku.

Fluoxetin:Vzacne byly hlaseny pripady zvysenych plazmatickych hladin trazodonu a nezadouci ucinky pri soucasnem podavani fluoxetinu a pripravku Trittico AC.

Inhibitory monoaminooxidazy (IMAO): Ojedinele byly hlaseny mozne interakce s inhibitory monoaminooxidazy (skupina antidepresiv). I kdyz nekteri lekari podavaji obe leciva soucasne, podavani trazodonu soubezne s IMAO, nebo behem dvou tydnu po ukonceni lecby temito pripravky, neni doporuceno. Taktez neni doporuceno podavani IMAO v prubehu jednoho tydne po ukonceni lecby trazodonem.

Fenothiaziny: Pri soucasnem podavani s fenothiaziny jako je chlorpromazin, flufenazin, levomepromazin a perfenazin byla pozorovana zavazna ortostaticka hypotenze (pokles krevniho tlaku pri rychlem vzprimeni).

Hypericum perforatum (trezalka teckovana): Nezadouci ucinky mohou byt castejsi, pokud je trazodon podavan spolu s pripravky obsahujicimi Hypericum perforatum (trezalku teckovanou).

Anestetika/my­orelaxancia: Trazodon muze zvysit ucinek inhalacnich anestetik a leku snizujicich napeti svalu, proto je treba v techto pripadech zvysene opatrnosti.

Levodopa: Antidepresiva mohou zrychlovat metabolizmus levodopy.

Warfarin: U pacientu soubezne uzivajicich trazodon a warfarin muze dojit ke zmenam protrombinove­ho casu.

Digoxin a fenytoin: Soucasne podavani s trazodonem muze vest ke zvyseni serovych hladin digoxinu a fenytoinu.

Antihypertenziva: I kdyz nebyly zaznamenany interakce s jinymi pripravky proti vysokemu krevnimu tlaku, je treba vzit v uvahu moznost zesilujiciho ucinku trazodonu.

Dalsi leciva: Soubezne podavani trazodonu a leku prodluzujicich QT interval muze zvysit riziko vzniku nekterych srdecnich komplikaci. Leky prodluzujici QT interval by mely byt spolecne s trazodonem podavany s opatrnosti.

Alkohol: Trazodon zvysuje sedativni ucinek alkoholu. Alkohol by nemel byt v prubehu lecby trazodonem pozivan.

Uzivani pripravku Trittico AC s jidlem a pitim Pripravek se uziva po jidle.

Tehotenstvi a kojeni Poradte se se svym lekarem nebo lekarnikem drive, nez zacnete uzivat jakykoliv lek. Podavani pripravku behem tehotenstvi a v obdobi kojeni by melo byt omezeno na vybrane pripady a pouze po dukladnem zhodnoceni pomeru rizik a prinosu lekarem. Moznost pruniku trazodonu do materskeho mleka by mela byt vzata do uvahy u kojicich zen. Data ziskana ze sledovani omezeneho poctu tehotnych zen vystavenych ucinkum trazodonu ukazuji, ze trazodon nema zadne vedlejsi ucinky na tehotenstvi nebo na zdravi plodu ci novorozence. V soucasne dobe nejsou k dispozici zadna dalsi relevantni epidemiologicka data. Pokud je trazodon uzivan az do porodu, novorozenci by meli byt monitorovani vzhledem k moznym abstinencnim priznakum.

Rizeni dopravnich prostredku a obsluha stroju Pripravek ma nizky nebo stredni vliv na rizeni dopravnich prostredku a obsluhu stroju. Pokud se u Vas vsak projevi ospalost, utlum, zavrate, stavy zmatenosti nebo rozmazane videni, neridte dopravni prostredky ani neobsluhujte stroje.

Dulezite informace o nekterych slozkach pripravku Trittico AC Pripravek obsahuje sacharozu. Pokud Vam Vas lekar rekl, ze nesnasite nektere cukry, poradte se se svym lekarem, nez zacnete tento lecivy pripravek uzivat.

3. JAK SE TRITTICO AC UZIVA

Vzdy uzivejte pripravek Trittico AC presne podle pokynu sveho lekare. Pokud si nejste jisty(a), poradte se se svym lekarem nebo lekarnikem. Pripravek je urcen k lecbe dospelych pacientu. Doporucuje se zacit terapeuticky cyklus vecerni davkou a denni davku postupne zvysovat. Lecivy pripravek by mel byt podavan v terapeutickych cyklech trvajicich nejmene jeden mesic. Snizeni vyskytu nezadoucich ucinku lze dosahnout podavanim trazodonu po jidle a uzivanim postupne se zvysujicich dennich davek az do maximalni davky doporucene lekarem. Tablety jsou delitelne na 3 casti, coz umoznuje postupne zvysovani davky podle zavaznosti onemocneni, hmotnosti, veku a celkoveho zdravotniho stavu pacienta. Pri ukoncovani lecby by se mela davka postupne snizovat. Nahlemu vysazeni lecby je treba se vyhnout.

Dospeli: Obvykle se podava 75–150 mg/den v jedne davce vecer pred spanim. Davka muze byt zvysena na 300 mg/den rozdelene ve dvou dilcich davkach. U hospitalizovanych pacientu se denni davka muze dale zvysit az na 600 mg/den, podanych v rozdelenych davkach. Pri lecbe sexualnich dysfunkci se podava 150–200 mg denne.

Starsi a oslabeni pacienti: Doporucena davka pro velmi stare pacienty, ci pacienty ve spatnem zdravotnim stavu je snizena na 100 mg/den podana ve dvou dilcich davkach nebo jednorazove jako nocni davka. Davka muze byt postupne zvysena dle davkovani pro dospele pod dohledem lekare a dle snasenlivosti a ucinnosti. Jednorazove davky vetsi nez 100 mg by nemely byt temto pacientu podavany.

Pouziti u deti a mladistvych do 18 let veku: Pripravek Trittico AC by nemel byt podavan detem a mladistvym do 18 let veku. Vas lekar vsak muze pacientum do 18 let pripravek Trittico AC predepsat, pokud usoudi, ze je to v jejich nejlepsim zajmu.

Pacienti s poruchou funkce jater: Trazodon podleha intenzivnimu jaternimu metabolizmu, viz kapitoly „Zvlastni opatrnosti pri pouziti pripravku Trittico AC je zapotrebi“ a „Nezadouci ucinky“. Pokud trpite poruchou jaternich funkci, zejmena poruchou zavazneho charakteru, informujte sveho lekare, ktery zvazi potrebu pravidelneho sledovani jaternich funkci.

Pacienti s poruchou funkce ledvin: Uprava davkovani neni obvykle nutna. Nicmene, pacienti trpici poruchou realnich funkci, zejmena v pripade zavaznejsiho onemocneni, by meli informovat sveho lekare pred zacatkem lecby pripravkem Trittico AC (viz take kapitola „Zvlastni opatrnosti pri pouziti pripravku Trittico AC je zapotrebi“).

Jestlize jste uzil(a) vice pripravku Trittico AC nez jste mel(a) V pripade nahodneho predavkovani ihned kontaktujte sveho lekare nebo navstivte nejblizsi zdravotnicke pohotovostni zarizeni. Vezmete s sebou tuto pribalovou informaci. Pri predavkovani nebo nahodnem poziti pripravku ditetem okamzite vyhledejte lekare. Jako prvni pomoc se pokuste vyvolat zvraceni. Pro lecbu predavkovani muze byt pouzito aktivni uhli nebo vyplach zaludku a mely by byt upraveny hladiny krevnich elektrolytu. Neexistuje specificky protilek. Priznaky predavkovani se mohou objevit behem 24 hodin i pozdeji. Nejcasteji zaznamenane priznaky pri predavkovani byly ospalost, zavrate, nevolnost a zvraceni. Ve vaznejsich pripadech bylo hlaseno koma, zrychlena srdecni cinnost, nizky krevni tlak, nizka hladina sodiku v krvi, krece a selhani dychaciho systemu. Srdecni symptomy mohou zahrnovat i bradykardii, prodlouzeni QT a Torsade de Pointes. Predavkovani trazodonem v kombinaci s dalsimi antidepresivy muze vyvolat serotoninovy syndrom.

Jestlize jste zapomnel(a) uzit pripravek Trittico AC Nezdvojujte nasledujici davku, abyste nahradil(a) vynechanou davku.

Jestlize jste prestal(a) uzivat pripravek Trittico AC Je treba se vyhnout nahlemu vysazeni lecby. Pri ukoncovani lecby by se mela davka postupne snizovat.

Mate-li jakekoli dalsi otazky, tykajici se uzivani tohoto pripravku, zeptejte se sveho lekare nebo lekarnika.

4. MOZNE NEZADOUCI UCINKY

Podobne jako vsechny leky, muze mit i pripravek Trittico AC nezadouci ucinky, ktere se ale nemusi vyskytnout u kazdeho. Behem lecby pripravkem nebo kratce po jejim skonceni byly hlaseny pripady sebevrazednych myslenek nebo chovani.

Trittico AC je antidepresivum se sedativnimi ucinky, ktere muze vyvolat ospalost behem prvnich dnu terapie, jez vetsinou vymizi pri jejim pokracovani. Nasledujici priznaky, ktere jsou bezne i u nelecene deprese, byly hlaseny take u pacientu lecenych trazodonem:

zmeny v krevnim obraze,

alergicke reakce,

syndrom neprimerene sekrece antidiuretickeho hormonu (porucha v udrzovani hladiny vody a sodiku v tele, projevujici se predevsim nadmernym prijmem tekutin a naslednou „otravou vodou“),

pokles hladiny sodiku v krvi, ztrata hmotnosti, zvysena chut k jidlu,

sebevrazedne myslenky nebo chovani, stavy zmatenosti, nespavost, dezorientace, manie, uzkost, nervozita, agitace (prilezitostne vedouci az k deliriu), klamy, agresivni reakce, halucinace, nocni mury, snizene libido, abstinencni priznaky,

serotoninovy syndrom (vysoka teplota, zaskuby ve svalech, zmatenost nebo neklid), krece, neurolepticky maligni syndrom (zvyseni telesne teploty, svalova ztuhlost, zmena stavu vedomi), ospalost, zavrate, bolest hlavy, matoznost, neklid, snizena pozornost, tres, rozmazane videni, poruchy pameti, myoklonus, expresivni afazie (poruchy vlastni tvorby reci – „hledani slov“), parestezie (pocity brneni, mravenceni), dystonie, zmeny chuti,

srdecni arytmie, bradykardie (zpomaleni srdecni frekvence), tachykardie (zrychleni srdecni frekvence), zmeny v EKG (prodlouzeni QT),

ortostaticka hypotenze (pokles krevniho tlaku pri rychlem vzprimeni), vysoky krevni tlak, synkopa (kratkodoba ztrata vedomi zpusobena nedostatecnym zasobenim mozku kyslikem v dusledku jeho nahleho nedokrveni podmineneho obvykle poklesem krevniho tlaku),

ucpani nosu, dusnost,

nevolnost, zvraceni, sucho v ustech, zacpa, prujem, travici obtize, bolesti v zaludku, gastroenteritida, zvysena tvorba slin, paralyticky ileus,

zmeny v jaternich funkcich (vcetne zloutenky a poskozeni jaternich bunek, intrahepatalni cholestaza),

vyrazka na kuzi, svedeni, nadmerne poceni,

bolesti v koncetinach a zadech, bolesti svalu ci kloubu,

potize s mocenim,

priapismus (pretrvavajici a bolestive ztoporeni penisu) – lecba trazodonem musi byt ihned ukoncena, pacient by mel vyhledat osetreni u lekare,

slabost, otok, priznaky podobne chripce, unava, bolest v hrudi, horecka,

zvysene hladiny jaternich enzymu.

Pokud se kterykoli z nezadoucich ucinku vyskytne v zavazne mire, nebo pokud si vsimnete jakychkoli nezadoucich ucinku, ktere nejsou uvedeny v teto pribalove informaci, prosim, sdelte to svemu lekari nebo lekarnikovi.

5. JAK PRIPRAVEK TRITTICO AC UCHOVAVAT

Uchovavejte mimo dosah a dohled deti. Uchovavejte pri teplote do 25°C, v puvodnim obalu, aby byl pripravek chranen pred svetlem a vlhkosti. Pripravek nesmi byt pouzivan po uplynuti doby pouzitelnosti vyznacene na obalu.

Lecive pripravky se nesmi vyhazovat do odpadnich vod nebo domaciho odpadu. Zeptejte se sveho lekarnika, jak mate likvidovat pripravky, ktere jiz nepotrebujete. Tato opatreni pomahaji chranit zivotni prostredi.

6. DALSI INFORMACE

Co pripravek Trittico AC obsahuje

Trittico AC 75 Lecivou latkou je trazodoni hydrochloridum 75 mg v jedne tablete. Pomocnymi latkami jsou sacharoza, karnaubsky vosk, povidon, magnesium-stearat.

Trittico AC 150 Lecivou latkou je trazodoni hydrochloridum 150 mg v 1 tablete. Pomocnymi latkami jsou sacharoza, karnaubsky vosk, povidon, magnesium-stearat.

Jak pripravek Trittico AC vypada a co obsahuje toto baleni

Popis pripravku: Trittico AC 75: bile az nazloutle, bikonvexni tablety, ovalneho tobolkoviteho tvaru, na kazde strane tablety jsou dve ryhy umoznujici rozdelit tabletu na tretiny. Trittico AC 150: bile az nazloutle, bikonvexni tablety, ovalneho tobolkoviteho tvaru, na kazde strane tablety jsou dve ryhy umoznujici rozdelit tabletu na tretiny.

Baleni: Trittico AC 75 obsahuje 30 tablet po 75 mg. Trittico AC 150 obsahuje 20 nebo 60 tablet po 150 mg. Na trhu nemusi byt vsechny velikosti baleni.

Drzitel rozhodnuti o registraci a vyrobce Drzitel rozhodnuti o registraci: Medicom International s. r.o. Brno, Ceska republika

Vyrobce: Aziende Chimiche Riunite Angelini Francesco ACRAF, Ancona Italie

Tento pribalovy letak byl naposledy schvalen 15.12.2011

Vice informaci o lecivem pripravku naleznete zde .

Upozorneni: Vyse uvedene udaje maji pouze informacni charakter. Kompletni a aktualni informace o lecivych pripravcich naleznete na webovych strankach Statniho ustavu pro kontrolu leciv www. sukl. cz .

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Cenestin (Synthetic Conjugated Estrogens) Side Effects, Interactions, Warning, Dosage & Uses, Cenest

ENDOMETRIAL CANCER, CARDIOVASCULAR DISODERS, BREAST CANCER AND PROBABLE DEMENTIA

Estrogen-Alone Therapy

Endometrial Cancer

There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Adding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer. Adequate diagnostic measures, including directed or random endometrial sampling when indicated, should be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding [see WARNINGS AND PRECAUTIONS ].

Cardiovascular Disorders and Probable dementia

Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia [see WARNINGS AND PRECAUTIONS. and Clinical Studies ]. The Women's Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT) in postmenopausal women (50 to 79 years of age) during 7.1 years of treatment with daily oral conjugated estrogens (CE) [0.625 mg]-alone, relative to placebo [see WARNINGS AND PRECAUTIONS. and Clinical Studies ].

The WHI Memory Study (WHIMS) estrogen-alone ancillary study of the WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 5.2 years of treatment with daily CE (0.625 mg)-alone, relative to placebo. It is unknown whether this finding applies to younger postmenopausal women [see WARNINGS AND PRECAUTIONS. Use in Specific Populations. and Clinical Studies ].

In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and other dosage forms of estrogens. Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

Estrogen Plus Progestin Therapy

Cardiovascular Disorders and Probable Dementia

Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia [see WARNINGS AND PRECAUTIONS. and Clinical Studies ].

The WHI estrogen plus progestin substudy reported increased risks of DVT, pulmonary embolism (PE), stroke and myocardial infarction (MI) in postmenopausal women (50 to 79 years of age) during 5.6 years of treatment with daily oral CE (0.625 mg) combined with medroxyprogesterone acetate (MPA) [2.5 mg], relative to placebo [see WARNINGS AND PRECAUTIONS. and Clinical Studies ].

The WHIMS estrogen plus progestin ancillary study of the WHI, reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with daily CE (0.625 mg) combined with MPA (2.5 mg), relative to placebo. It is unknown whether this finding applies to younger postmenopausal women [see WARNINGS AND PRECAUTIONS. Use in Specific Populations. and Clinical Studies ].

Breast Cancer

The WHI estrogen plus progestin substudy also demonstrated an increased risk of invasive breast cancer [see WARNINGS AND PRECAUTIONS. and Clinical Studies ].

In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and MPA, and other combinations and dosage forms of estrogens and progestins. Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DRUG DESCRIPTION

Cenestin (synthetic conjugated estrogens, A) tablets contain a blend of nine (9) synthetic estrogenic substances. The estrogenic substances are sodium estrone sulfate, sodium equilin sulfate, sodium 17α-dihydroequilin sulfate, sodium 17α-estradiol sulfate, sodium 17βdihydroequilin sulfate, sodium 17α-dihydroequilenin sulfate, sodium 17β-dihydroequilenin sulfate, sodium equilenin sulfate and sodium 17β-estradiol sulfate.

The structural formulae for these estrogens are:

Sodium Estrone Sulfate

Sodium Equilin Sulfate

Sodium 17β-Estradiol Sulfate

Tablets for oral administration, are available in 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg and 1.25 mg strengths of synthetic conjugated estrogens, A. Tablets also contain the following inactive ingredients: ethylcellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, polysorbate 80 (except 0.45 mg tablets ), pregelatinized starch, titanium dioxide, and triethyl citrate.

0.3 mg tablets also contain FD&C Blue No. 2 aluminum lake and D&C Yellow No. 10 aluminum lake.

0.45 mg tablets also contain FD&C Yellow No. 6/Sunset Yellow FCF lake.

0.625 mg tablets also contain FD&C Red No. 40 aluminum lake.

0.9 mg tablets do not contain additional color additives.

1.25 mg tablets also contain FD&C Blue No. 2 aluminum lake.

What are the possible side effects of conjugated estrogens (Cenestin, Enjuvia, Premarin)?

Get emergency medical help if you have any of these signs of an allergic reaction . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using conjugated estrogens and call your doctor at once if you have a serious side effect such as:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

sudden numbness or weakness, especially on one side of the body;

sudden severe headache, confusion, problems with vision, speech, or balance;

pain.

What are the precautions when taking synthetic conjugated estrogens (Cenestin)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: vaginal bleeding of unknown cause, certain cancers (such as breast cancer, cancer of the uterus/ovaries), blood clots, stroke, heart disease (such as heart attack), liver disease, kidney disease, family medical history (especially breast lumps, cancer, blood clots, angioedema), blood clotting disorders (such as protein C or protein S deficiency), high blood pressure, diabetes, high cholesterol/triglyceride levels.

Last reviewed on RxList: 4/6/2015 This monograph has been modified to include the generic and brand name in many instances.



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Cifloxin review

Cifloxin is very useful in the treatment of an array of bacteria and produces less potential side effects compared to others in its class. Cifloxin is the generic name of the antibiotic that is available by the brand names Cipro. Ciprobay and Ciproxin. It is a fluoroquinolone, which acts as a bacteriocidal. Usually, bacteria in the human body are eliminated and the growth and spread is stopped through inhibitive actions. Cifloxin is used against a variety of bacterial infections including some urinary tract infections as well as the treatment and prevention of anthrax.

Cifloxin is a broad-spectrum antibiotic effective against Gram-negative and Gram-positive bacteria. It acts on enzymes to prevent bacterial cell division. Included in the bacteria that it fights are enterobacteriaceae, brucella, neisseria, campylobacter. vibrio, mycobacterium intracellulare, legionella sp. pseudomonas aeruginosa, Escherichia coli, streptococcus pneumoniae and Chlamydia. However, it is not as effective against bacteroides, entercoccus faecium, streptococcus pyogenes and ureaplasma urealyticum.

Cifloxin causes several side effects but incidences are mostly safe and manageable. Compared to other fluoroquinolones, severity and frequency is low and usually mild to moderate. Mild to moderate side effects that should be reported to your doctor include nausea. vomiting. stomach pain, indigestion, headache. diarrhea. nervousness, anxiety. irritability, nightmares, insomnia. feelings of distrust, vaginal itching or discharge. Serious side effects should immediately be reported to your doctor and patients should stop taking Cifloxin. Symptoms include rashes, hives. joint and muscle pain. fainting, arrhythmia, hoarseness of voice, tingling sensation, easily languord, loss of appetite. pyrexia, hallucination, depression. double vision, seizure, suicidal ideations and loss of sensitivity to touch.

Patients with known hypersensitivity to quinolones and fluoroquinolones should be cautious about taking the medicament. Cifloxin may interact negatively with tizanidine. anticoagulants, acetazolamide, anti-diarrheals, methotrexate and anti-inflammatory medicaments. Patients should consult their doctor if they are taking any herbal medicaments or nutritional supplements. Operating machinery and driving are discouraged until the effects of this medicament are fully realized. The medicament also increases skin sensitivity to ultraviolet light and sunlight but sunburns are not normal and should be reported.

Cifloxin works to block bacterial DNA proliferation and spread by binding to the DNA gyrase enzyme. This enzyme is a type II topoisomerase and important in separating replicated DNA. The binding action causes double-stranded breaks in the chromosome of the bacteria, which stops cell division. The medicament also directly acts on any existing bacteria by killing them.

In a study, 24 women ages 22 to 32 suffering from urinary tract infections were given 500 mg of Cifloxin twice daily in the form of oral tablets. After 1 week, half the women were free from symptoms and by the end of the second week, all women were fully healed. Only 3 participants reported mild side effects while the others did not experience any adverse reactions.

Cifloxin is a nonprescription medicament and can be bought at pharmacies and drug stores. Be sure to check the expiration date, manufacturer and location to ensure the product is still good. When buying over the internet, be sure that the source is valid by checking the address and asking for verification.

Cifloxin is taken according to the recommended dose. Never double the dose if you miss one. Each dose should be taken with a full glass of water and pills should be swallowed whole, not crushed or chewed. Patients are discouraged from taking the medicament with dairy products. The medicament should be stored at room temperature and kept out of children's reach at all times.

Cifloxin has the following structural formula:

• Molecular formula of cifloxin is C17H18FN3O3 • Chemical IUPAC Name is 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid • Molecular weight is 331.342 g/mol • Cifloxin available. 0.3% solution 10ml bottle, 0.3% solution 2.5ml bottle, 0.3% solution 5ml bottle, 250mg tablets, 500mg tablets, 750mg tablets

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CEFACAR

Composición

Comprimidos dispersables Cefadroxilo 500 mg y Comprimidos 1 g. Suspensión 250/5ml y 500 mg/5 ml: Cefadroxilo. Inyectable: 500 mg y 1 g.

Para Que Sirve

Antibiótico de amplio espectro, del grupo de las cefalosporinas, con actividad bactericida frente a gérmenes grampositivos (estafilococos, estreptococos, incluyendo a cepas penicilinarresistentes) y gramnegativos (Escherichia coli, Proteus, Klebsiella pneumoniae y Haemophilus influenzae).

Presentación

500 mg x 8 y 16 comprimidos dispersables. 1 g x 8 y 16 comprimidos. Inyectable: 500 mg y 1 g x 1 frasco ampolla. Suspensión 250 mg/5 ml x 60, 90 y 120 ml. Suspensión 500 mg/5 ml x 60, 90 y 120 ml.

Como tomar

Adultos 1 comprimido cada 12 horas. Niños hasta 40 kg de peso: 25 mg/kg/día repartidos en 2 tomas, 1 cada 12 hs. Puede administrarse hasta 4 g diarios en adultos y hasta 100 mg/kg/día en niños, distribuidos en 2 o 3 tomas. Inyectable: 1 frasco ampolla i. m. cada 12-24 hs. Los comprimidos dispersables pueden ingerirse enteros o disueltos en agua (aprox 30 cc).

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Chloramphenicol is indicated for the topical treatment of infections due to micro-organisms sensitive to the anti-infective.

"Adults (including the Elderly) and Children One to two drops applied topically to each affected eye up to six times daily or more frequently if required. (Severe infections may require one to two drops every fifteen to twenty minutes initially, reducing the frequency of instillation gradually as the infection is controlled)."

Local Sensitivity reactions such as transient irritation, burning, stinging, itching and dermatitis, may occasionally occur. Systemic Rarely, cases of major adverse haematological events (bone marrow depression, aplastic anaemia and death) have been reported following ocular use of chloramphenicol.

Chymotrypsin will be inhibited if given simultaneously with chloramphenicol.

In severe infections topical use of chloramphenicol should be supplemented with appropriate systemic treatment. Aplastic anaemia has, very rarely, followed topical use of chloramphenicol eye drops and, whilst this hazard is an uncommon one, it should be borne in mind when the benefits of the use of chloramphenicol are assessed. Prolonged use should be avoided as it may increase the likelihood of sensitisation and the emergence of resistant organisms. Chloramphenicol should be reserved for use only in infections for which it is specifically indicated. Contact lenses should be removed during the period of treatment. Systemic absorption may be reduced by compressing the lacrimal sac at the medial canthus for a minute during and following the instillation of the drops. (This blocks the passage of the drops via the naso lacrimal duct to the wide absorptive area of the nasal and pharyngeal mucosa. It is especially advisable in children.)

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ELIXOPHYLLIN Rx

Indications for ELIXOPHYLLIN:

Treatment of symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases (eg, emphysema, chronic bronchitis).

Adults and Children:

Individualize. Calculate based on ideal body weight. 26 weeks, divide dose into 4 equal amounts given at 6hr intervals. Adjust to maintain peak steady state serum theophylline concentration of 5–10mcg/mL in neonates and 10–15mcg/mL in older infants. Children (1–15yrs) and adults (16–60yrs) without risk factors for impaired clearance: children 45kg and adults: initially 300mg/day divided every 6–8hrs; after 3 days, if tolerated, increase to 400mg/day divided every 6–8hrs; after 3 more days, if tolerated, increase to 600mg/day divided every 6–8hrs. Patients with risk factors for impaired clearance, elderly, and in those whom it is not feasible to monitor theophylline concentrations: 1–15yrs: final dose not exceed 16mg/kg/day up to max 400mg/day; ?16yrs: final dose not exceed 400mg/day. Loading dose for acute bronchodilation: a single 5mg/kg dose. Dose adjustments based on theophylline concentrations: see literature.

Warnings/Precautions:

Active peptic ulcer. Arrhythmias. Seizure disorders. Hepatic dysfunction. CHF. Acute pulmonary edema. Cor pulmonale. Hypothyroidism. Fever. Sepsis. Shock. Monitor serum levels (blood sample should be obtained at time of expected peak serum theophylline concentration; 1–2 hours after a dose at steady-state); do not try to maintain non-tolerated doses. Monitor serum theophylline concentrations at 6 month intervals for rapidly growing children and yearly for all others. Acutely ill: monitor more frequently (eg, every 24 hours). Slow or rapid metabolizers. Reduced renal function in infants <3 months old. Elderly. Pregnancy (Cat. C). Nursing mothers: not recommended.

Interactions:

See literature. Smokers have increased metabolism. Potentiated by quinolones, macrolides, cimetidine, alcohol, allopurinol, estrogen oral contraceptives, tacrine, interferon alpha, disulfiram, fluvoxamine, verapamil, mexiletine, methotrexate, pentoxifylline, propafenone, propranolol. ticlopidine, thiabendazole. Antagonized by aminoglutethimide, phenytoin, rifampin, barbiturates, carbamazepine, ritonavir, sucralfate, isoproterenol, moricizine, sulfinpyrazone. Avoid ?-blockers. Antagonizes lithium, benzodiazepines, pancuronium, adenosine. Toxicity with sympathomimetics. Seizures with ketamine. Arrhythmias with halothane.

Pharmacological Class:

Adverse Reactions:

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Beximco manufactures wide range of products which includes xidolac eye drops. It belongs to eye care products category. It is supplied as a sterile isotonic aqueous 0.5% solution. It is indicated for seasonal allergic conjunctivitis and for pain and inflammation in ocular surgery. It is also indicated for the treatment of postoperative inflammation in patients who have undergone cataract extraction. It offers: reduces postoperative pain, inflammation, burning/stinging of the eye, commonly use in prophylaxis therapy for cataract and corneal refractive surgery, etc.

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Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis. Diclofenac may also be used for purposes other than those listed in this medication guide.

Use Diclofenac as directed by your doctor.

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Drug Class and Mechanism

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Do not use Diclofenac if:

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