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Adoption & Foster Care Certificate Program

THE CERTIFICATE IN ADOPTION AND FOSTER CARE PRACTICE provides clinical and practical training for those working with families and children whose lives are touched by the issues of foster care and adoption.

Please note: Workshops in the Adoption and Foster Care Practice Certificate Program are open to all. You do not need to be seeking an AFCC certificate.

Our Vision: Adoption and foster care competent professionals throughout the greater Rhode Island area.

Our Mission: Through the Adoption and Foster Care Certificate program, we will promote adoption and foster care competent professionals as resources to support permanency for children in Rhode Island’s child welfare system.

Pre-2014 Certificate Completion Form - This form applies to participants who started the program prior to the Fall semester of 2014.

Current Certificate Completion Form - This form applies to participants who started the program during or after the Fall semester of 2014.

Program Requirements:

There are eleven required core courses. Participants will also be required to attend three elective courses, which cover a wide range of topics. In order to receive credit towards the certificate, participants are asked to complete a short post-test. Courses are held at the Rhode Island College School of Social Work. Core courses are listed below. Please click on each course title for further information.

Core Workshops :

AFCC-36 Policy and Advocacy: Impacts on Care and Adoption (Core)

AFCC-37 Understanding Core Clinical Issues in Foster Care and Adoption (Core)

AFCC-38 Trauma & Brain Development: Foundations for Foster Care & Adoption Practice (Core)

AFCC-47 Ethics: Reflective Practice (Core)

There are no elective workshops for the AFCC program this semester.

Course Descriptions:

AFCC-36 Policy and Advocacy: Impacts on Care and Adoption (Core)

This course focuses on the history of child welfare in Rhode Island. Relevant laws and policies are discussed and dissected to determine their impacts on adoption and foster care. Participants learn about the importance of advocacy and use role-playing to demonstrate new skills and knowledge.

AFCC-37 Understanding Core Clinical Issues in Foster Care and Adoption (Core)

This workshop explores seven core clinical issues associated with adoption & foster care practice. Through the training, participants cultivate an understanding of these clinical issues and their relevance to the human experience and the meaning they hold for individuals. The workshop presents a strength-based approach to viewing developmental and situational aspects of adoption & foster care experiences. Scenario-based exercises are used to allow participants to make connections with the new knowledge learned.

AFCC-38 Trauma & Brain Development: Foundations for Foster Care & Adoption Practice (Core)

This training explores neurological and environmental effects of trauma on children who are survivors of abuse and neglect. During training, participants learn about brain development in children and adolescents. This course also introduces participants to strategies that assist with healing from trauma and techniques for creating healthy relationships.

AFCC-47 Ethics: Reflective Practice

This workshop addresses the identification and exploration of ethical and legal issues that are relevant to adoption and foster care. This training provides participants with the opportunity to confront biases that can impact clinical practice. The training provides participants with a framework for ethical decision making.

AFCC Faculty:

AFCC faculty includes professionals from various fields of expertise, such as social work, counseling, and psychology.

Catherine Lewis . MSW & LICSW is a clinical social worker having worked more than 25 years with foster and adoptive children and families. She is an adjunct professor in the Rhode Island College of Social Work and is in private practice. Catherine Lewis is the trainer for AFCC-42 Working With and Understanding the Role of Birth families.

Daniel Harvey . LICSW is an Assistant Professor at the Rhode Island College of School of Social Work. He is a licensed clinician, with approximately three decades of experience in addressing the needs of children experiencing trauma. Daniel Harvey is the trainer for AFCC-38 Foundations for Foster Care and Adoptions Practice: Trauma and Brain Development and AFCC-46 Clinical Work with Foster Care and Adoptive Families: Promoting Positive Identify and Managing Challenging Behaviors.

Deoshore Haig . MSW is the Director of Haig & Associates, has over twenty-five years of experience working with culturally diverse communities in social services, and managing health and human service programs. As an independent consultant, Deoshore’s services include designing and facilitating diversity and cultural competency training, advising in program development, conducting program evaluations, and providing technical assistance for organizational development. Deoshore Haig is the trainer for AFCC-41 Considering the Value and Role of Culture and Diversity.

Frederic Reamer . Ph. D. is professor in the School of Social Work, Rhode Island College. He has published extensively on professional ethics and chaired the national task force that wrote the current NASW Code of Ethics. Reamer frequently serves as an expert witness in litigation and licensing board cases. Frederic Reamer is the trainer for AFCC-47 Ethics: A Reflective Practice.

Lori Geiselman . MSW is a clinical training specialist for the Department of Children, Youth and Families. She has worked primarily within the field of Public Child Welfare. She has held positions as a Social Case Worker II, Clinical Social Worker, and Clinical Training Specialist within the Department of Children, Youth and Families and the Child Welfare Institute. In the last year, Lori is also a clinician for Rhode Island Hospital’s Emergency Services. Lori Geiselman is the trainer for AFCC-37 Understanding Core Clinical Issues in Foster Care and Adoption.

Melinda Gushwa . MSW, PhD, is an assistant professor at Simmons College School of Social Work. She has over 17 years of practice experience in the areas of public child welfare, psychotherapy, mental health case management and medical social work. Melinda Gushwa is the trainer for AFCC-40 Grief and Loss in Foster Care and Adoption.

Pamela Lowell . LICSW is an author and licensed clinical social worker in private practice with twenty-five plus years of experience counseling children and their families. She is a clinical consultant at Adoption Rhode Island where she provides case consultation to staff and community collaborators. Pamela Lowell is the trainer for AFCC-Clinical Work with Foster Care and Adoptive Families: Family Formation and Development Stages.

Contact AFCC

Joining the email list is the most effective way to keep informed on upcoming workshop and course offerings. If you need further assistance, please contact Krista Handfield by phone or email. Email and phone messages are returned with-in 3-5 business days. If you need immediate assistance, please contact the program administrator Sue Pearlmutter. Contact information is below:

Sue Pearlmutter, PhD AFCC Program Administration Dean and Professor Rhode Island College School of Social Work 600 Mount Pleasant Avenue Providence, RI 02908 Email: rpearlmutter@ric. edu Telephone: (401) 456-8043

Krista Handfield Program Coordinator & Graduate Assistant Rhode Island College School of Social Work 600 Mount Pleasant Avenue Providence, RI 02908 Email: afcc@ric. edu Telephone: (401) 456-2753

The Adoption & Foster Care Certificate is a program in partnership with:

Rhode Island College School of Social Work

Rhode Island Department of Children, Youth and Families (DCYF)

Adoption Rhode Island

Beacon Health Strategies

Child & Family

Family Service of Rhode Island



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Product Description Common use Noroxin is quinolone antibiotic used for treatment of urinary tract such as pyelonephritis, cystitis, urethritis), genitals (prostatitis, cervicitis, endometritis), gastrointestinal tract (salmonellosis, shigellosis), uncomplicated gonorrhea. Mechanism of its action consists in inhibition of DNA gyrase leading to destabilization of the bacterial DNA and death of the susceptible bacteria. Noroxin is active against Staphylococcus spp. (including Staphylococcus aureus), Neisseria spp. E. coli, Citrobacter spp. Klebsiella spp. Proteus spp. Salmonella spp. Enterobacter spp. Hafnia, Shigella spp. Mycobacterium tuberculosis, Vibrio cholerae, Haemophilus influenzae, Chlamydia spp. Mycoplasma spp. and some others. Medication is active for 12 hours.

Dosage and directions To treat infections of urinary tract, take 400 mg of Noroxin two times a day during 7-10 days, to treat non-complicated cystitis treatment continues 3-7 days, and in patients with recurrent chronic infection of urinary tract it is up to 12 weeks. For prostatitis the recommended daily dose is 800 mg, divided into 2 doses, for four weeks. Usual single recommended dose to treat gonorrhea is 800 milligrams for 1 day. The maximal daily dose is 800 milligrams. Take with a full glass of water two hours after a meal or one hour before it. Drink plenty of water while taking Noroxin to avoid formation of needle-shaped crystals in your urine. The elderly and people with kidney problems may need to use a reduced dosage or have their kidney function monitored. Take exactly as prescribed by your doctor. Do not start or stop treatment without your doctor's permission.

Precautions In elderly and patients with kidney impairment, kidney function monitoring is required on a regular basis. This medication may cause photosensibilization, avoid direct sun rays during treatment. Limit consummation of alcoholic beverages as they may worsen such side effects as dizziness, drowsiness and others which may affect your ability to operate machinery and driving.

Contraindications This medication cannot be administered in patients with hypersensitivity to Noroxin, pregnant and breastfeeding women, children under 18 y. o. individuals with glucose-6-phosphate dehydrogenase deficiency. Caution is required when Noroxin is administered in individuals with cerebral arteriosclerosis, cerebrovascular dysfunctions, epilepsy, epileptic syndrome, Myasthenia gravis, kidney or liver failure.

Possible side effect The most common side effects include: weakness, headache, drowsiness, dizziness, nausea, stomach upset. Rare but serious side effects are: tremor and sun sensitivity, seizures, mental/mood changes, sore throat/fever, vision changes, hearing loss, change in amount or appearance of urine, jaundice, fainting, changes in heartbeat, easy bruising or bleeding, numbness or tingling of extremities. Tendon damage and weakening of muscles is rare but possible. Stop exercising and claim prompt medical attention if you experience pain in your joint or tendon. In case of pseudomembranous colitis (persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool) which may develop even a few weeks after the treatment was discontinued, do not use anti-diarrhea products or narcotic pain medications. Tell your doctor immediately about your condition. Prolonged or repeated used of Noroxin may cause oral thrush or a new vaginal yeast infection with such symptoms as: white patches in the mouth, a change in vaginal discharge. Inform your doctor immediately if you experience allergic reaction (severe dizziness, rash, itching, swelling, trouble breathing).

Drug interaction Theophylline dose should be decreased while on Noroxin. Noroxin increases the blood concentration of indirect anticoagulants, cyclosporine, decreases effects of nitrofurans. Antacids which contain ions of Al and Mg, medications which contain Fe, Zn2+, sucralfate should be taken at least with four hour interval with Noroxin. Concomitant intake with the medicines decreasing epileptic threshold may lead to epileptic attacks. Dangerous sudden drop in blood pressure or changes in heart rhythm are possible when Noroxin is concomitantly used with the drugs for blood pressure or affecting the heart rhythm. Inform your doctor about all prescribed and over-the-counter medications and herbal products you are taking.

Missed dose If you miss a dose, take it as soon as you remember unless it is almost time of your next dose. If it is near the time of the next dose, skip the missed dose and return dosing schedule. Do not double the dose to make up the missed dose.

Overdose Symptoms of overdose include: dizziness, nausea, vomiting, drowsiness, "cold" sweating, puffy face without major changes in hemodynamic indices.

Storage Store at room temperature in a tight container, away from moisture and humidity.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.



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Epinor Activities

In EPINOR there are two annual events offered PhD candidates; The EPINOR Summer School and The EPINOR Annual Meeting. As a member of EPINOR it is expected that the PhD candidates participate in these two events yearly.

The EPINOR Annual Meeting

This year’s annual meeting is in Bergen on September 28th, the day after the annual NOFE Conference, which is arranged in Bergen September 26th and 27th. If you also attend the NOFE conference, you must register to that conference separately.

The EPINOR Summer School

A National Summer School will take place every year where the EPINOR students are expected to participate. The Summer School will normally be the first week of June from Monday to Friday. The Scientific topic and venue will change every year. All EPINOR students are invited to join as well as their supervisors. Another important part of the Summer School is the social activities. Students and supervisors will have joint social activities at the Summer Schools.

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Gentamicin Injection Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Gentamicin

gentamicin injection

GENERIC NAME(S): GENTAMICIN SULFATE

Warnings

This medication can cause serious kidney problems and nerve damage. resulting in permanent hearing loss (including deafness or decreased hearing) and balance problems. The risk is increased if you are older, already have kidney disease. or if you have a severe loss of body water (dehydration ). Your risk is also increased if you receive high doses, or with longer use of this medication.

Tell your doctor right away if you notice ringing/roaring sounds in the ears, hearing loss. dizziness. or an unusual decrease in the amount of your urine.

Careful monitoring by your doctor will reduce the risk of these side effects. Monitoring may include hearing, kidney. urine, and drug blood level tests.

Avoid other medications that may increase your risk for these serious side effects if taken together with gentamicin. See also Drug Interactions section.

Uses

This medication is used to prevent or treat a wide variety of bacterial infections. Gentamicin belongs to a class of drugs known as aminoglycoside antibiotics. It works by stopping the growth of bacteria.

How to use gentamicin injection

This medication is given by injection into a vein or muscle as directed by your doctor, usually every 8 hours. The dosage is based on your medical condition, weight. and response to treatment. Laboratory tests (such as kidney function, levels of drug in the blood ) may be performed to help find the best dose for your condition.

If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, use this drug at evenly spaced intervals.

Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.

Tell your doctor if your condition persists or worsens.

Side Effects

See also Warning section.

Nausea. vomiting. stomach upset, or loss of appetite may occur. Pain/irritation/redness at the injection site may rarely occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: numbness/tingling, muscle twitching or weakness. seizure .

This medication may rarely cause a severe intestinal condition (Clostridium difficile - associated diarrhea ) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain /cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth. a change in vaginal discharge. or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction. rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using gentamicin, tell your doctor or pharmacist if you are allergic to it; or to other aminoglycoside antibiotics (such as tobramycin. amikacin ); or if you have any other allergies. This product may contain inactive ingredients (such as sulfites), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: cystic fibrosis. hearing problems (including deafness, decreased hearing), kidney problems, low blood minerals (including potassium. magnesium. calcium ), myasthenia gravis. Parkinson's disease .

Gentamicin may cause live bacterial vaccines (such as typhoid vaccine) not to work as well. Therefore, do not have any immunizations /vaccinations while using this medication without the consent of your doctor.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the effects of this drug, especially kidney damage.

This medication is not recommended for use during pregnancy. Although there have been reports of harm in babies born to women using similar drugs, the risk for harm may not be the same with this drug. Discuss the risks and benefits with your doctor.

This drug passes into breast milk in small amounts. However, many doctors consider breastfeeding safe while using this medication. Consult your doctor before breastfeeding.

Interactions

See also Warning section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Other medications that may affect the kidneys or hearing may increase the risk of kidney damage or hearing loss if taken with gentamicin. Some affected drugs include: amikacin, tobramycin, amphotericin B, cidofovir, cisplatin, polymyxin B, cephalosporins such as cephaloridine, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, among others.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Laboratory and/or medical tests (such as kidney function, levels of drug in your blood) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule. Do not double the dose to catch up.

Storage

Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Ketotifen Ophthalmic Medlineplus Drug Information, Ketotifenum

Ketotifen Ophthalmic

How should this medicine be used?

Ophthalmic ketotifen comes as a solution (liquid) to instill in the eye. It is usually instilled in the affected eye(s) twice daily, 8 to 12 hours apart. Instill ketotifen eye drops at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use ketotifen exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

To instill the eye drops, follow these steps:

Wash your hands thoroughly with soap and water.

Check the dropper tip to make sure that it is not chipped or cracked.

Avoid touching the dropper tip against your eye or anything else; eye drops and droppers must be kept clean.

While tilting your head back, pull down the lower lid of your eye with your index finger to form a pocket.

Hold the dropper (tip down) with the other hand, as close to the eye as possible without touching it.

Brace the remaining fingers of that hand against your face.

While looking up, gently squeeze the dropper so that a single drop falls into the pocket made by the lower eyelid. Remove your index finger from the lower eyelid.

Close your eye for 2 to 3 minutes and tip your head down as though looking at the floor. Try not to blink or squeeze your eyelids.

Place a finger on the tear duct and apply gentle pressure.

Wipe any excess liquid from your face with a tissue.

If you are to use more than one drop in the same eye, wait at least 5 minutes before instilling the next drop.

Replace and tighten the cap on the dropper bottle. Do not wipe or rinse the dropper tip.

Wash your hands to remove any medication.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before using ketotifen eye drops,

tell your doctor and pharmacist if you are allergic to ketotifen or any other medications.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using ketotifen, call your doctor.

you should know that you should not wear contact lenses if your eye(s) is/are red. If your eyes are not red and you wear contact lenses, you should know that ketotifen solution contains benzalkonium chloride, which can be absorbed by soft contact lenses. Remove your contact lenses before instilling ketotifen and put them back in 10 minutes later.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Instill the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not instill a double dose to make up for a missed one.

What side effects can this medication cause?

Ketotifen eye drops may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

headache

runny nose

burning or stinging of the eye

eye discharge

dry eyes

eye pain

eyelid problems

itching

problem with tear production

blurred vision

sensitivity to light

rash

flu-like symptoms

sore throat

Ketotifen eye drops may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo. gl/c4Rm4p ) for more information if you do not have access to a take-back program.

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names



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Se%20parece - Spanish To English Translation, Paracen

Translate Se%20parece To English

look alike, look

(v.) = bear + similarity ; look + alike ; take after . Ex: If one walks round a large general booskshop and carefully appraises the stock on display it becomes clear quite quickly that there are many types of books which seem to bear a strong similarity to each other . Ex: No two paper moulds of the hand-press period were ever precisely identical, and individual moulds can be identified by their paper images; even the two moulds of a pair, which were deliberately made to look alike . can be told apart by the paper made in them . Ex: Libraries are like chameleons: they take after the complexion of society .



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Antalgin Generic Name Levorphanol Online, Antalgin

Antalgin General Information

Antalgin - Pharmacology:

Like other mu-agonist opioids it is believed to act at receptors in the periventricular and periaqueductal gray matter in both the brain and spinal cord to alter the transmission and perception of pain.

Antalgin Interactions

Interactions with Other CNS Agents: Concurrent use of Levo-Dromoran with all central nervous system depressants (eg, alcohol, sedatives, hypnotics, other opioids, general anesthetics, barbiturates, tricyclic antidepressants, phenothiazines, tranquilizers, skeletal muscle relaxants and antihistamines) may result in additive central nervous system depressant effects. Respiratory depression, hypotension, and profound sedation or coma may occur. When such combined therapy is contemplated, the dose of one or both agents should be reduced. Although no interaction between MAO inhibitors and Levo-Dromoran has been observed, it is not recommended for use with MAO inhibitors.

Most cases of serious or fatal adverse events involving Levo-Dromoran reported to the manufacturer or the FDA have involved either the administration of large initial doses or too frequent doses of the drug to nonopioid tolerant patients, or the simultaneous administration of levorphanol with other drugs affecting respiration. The initial dose of levorphanol should be reduced by approximately 50% or more when it is given to patients along with another drug affecting respiration.

Interactions with Mixed Agonist/Antagonist Opioid Analgesics: Agonist/antagonist analgesics (eg, pentazocine, nalbuphine, butorphanol, dezocine and buprenorphine) should NOT be administered to a patient who has received or is receiving a course of therapy with a pure agonist opioid analgesic such as Levo-Dromoran. In opioid-dependent patients, mixed agonist/antagonist analgesics may precipitate withdrawal symptoms.

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Richard Lefrak - Family, Lefra

#205 Richard LeFrak & family

Real Time Net Worth As of 9/19/16

$6.7 Billion

Age 71 Source Of Wealth real estate Self-Made Score 5 Residence New York, NY Citizenship United States Marital Status Married Children 2 Education Bachelor of Arts / Science, Amherst College; Doctor of Jurisprudence, Columbia University

Richard LeFrak and partner Turnberry Associates broke ground in June 2015 on a 183-acre site in North Miami to be called SoLeMia that will eventually have more than 4,000 residential units and some 1 million square feet of retail and commercial space. It's the latest project for LeFrak, who's been in his family's real estate business since 1968. His grandfather, Harry, began developing properties in 1901. Now LeFrak is one of the biggest landlords in the tristate area, known for his 5,000-unit apartment complex LeFrak City in Queens, N. Y. and over 16 million square feet of commercial, residential and retail properties in Newport, N. J. More »

More On Forbes

The biggest shareholders in NorthStar Asset Management are challenging the real estate investment firm’s merger with Thomas Barrack’s Colony Capital, arguing that the tie-up undervalues their shares and should be restructured. read »

Formula One is one of the most high-speed, high-tech and high-pressure sports with hundreds of millions of Dollars of prize money on the line in decisions which need to be made in hundredths of seconds. It makes the series as much a showcase of management and strategy as athleticism and sport. Books have been written on what it takes to run a read »

Private equity firm CVC has been praised for the turbo-charged return on its investment in Formula One auto racing. However if the sale of F1 to Liberty Media Group gets the green light from regulators it could prove to be one of the worst exits in CVC’s history as it stands to get at most $354 million in cash for its controlling stake. read »

The maker of camera-based vehicle sensor systems and Tesla have differing versions of why their relationship collapsed. read »

Mark Cuban says he’ll give a charity of Donald Trump’s choice (or Trump himself) $10 million if he does a four-hour interview with Cuban about his policies. Cuban’s challenge came hours after Trump said Cuban wasn’t smart enough to understand his policies. read »

A leading sports lawyer says that the legitimacy of the $8 billion sale of Formula One auto racing to conglomerate Liberty Media could be called into question due to a potential conflict of interest.

It confirms our exclusive last week that the contractual arrangements at the heart of F1 may need to be restructured if the sale to Liberty read »

Billionaire John Paulson remains confident on pharmaceuticals, even as the sector punishes his hedge fund’s performance. read »

A new report says Subaru picked up nearly 3.5 times more customers than it lost to other brands over the last year. read »

Here’s how Warren Buffett can respond to the fake account scandal at Wells Fargo, from stock swaps to shareholder activism. read »

A Peter Thiel spokesperson said that The Huffington Post’s sources are “lying” over a report that the billionaire investor is being considered for the highest court in the land. read »

Catering to billionaires and other wealthy entrepreneurs is becoming a greater priority at UBS. Advising on philanthropic giving is part of its latest push. read »

The billboard magnate passed away on Wednesday morning September 14. read »

The Facebook CEO sold $95 million of Facebook stock on Sept. 9 and Sept. 12 as part of his ongoing plan to give away 99% of his holdings in the company. read »

Amazon CEO Jeff Bezos is once again the third richest person in the world and the second richest person in America, unseating Warren Buffett, who lost $1.3 billion Tuesday in the fallout of Wells Fargo’s fake account scandal. read »

With no facts offered to support his extreme opinions, self-described neo-Nazi Andrew Anglin, who has endorsed Trump, portrays Hispanic immigrants as “loafing” and having a “lower IQ” and says women are “not fully conscious beings.” read »

A high-flying Chinese billionaire is making one of the country’s costliest divorce settlements ever. read »



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Microfollin Indication, Action Of Microfollin, Interactions, Microfollin

Microfollin [in more detail]

For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.

Microfollin Mechanism Of Action:

Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

Microfollin Drug Interactions:

Aminophylline The contraceptive increases the effect and toxicity of theophylline Dyphylline The contraceptive increases the effect and toxicity of theophylline Oxtriphylline The contraceptive increases the effect and toxicity of theophylline Theophylline The contraceptive increases the effect and toxicity of theophylline Amobarbital This product may cause a slight decrease of contraceptive effect Aprobarbital This product may cause a slight decrease of contraceptive effect Butabarbital This product may cause a slight decrease of contraceptive effect Butalbital This product may cause a slight decrease of contraceptive effect Butethal This product may cause a slight decrease of contraceptive effect Carbamazepine This product may cause a slight decrease of contraceptive effect Ethotoin This product may cause a slight decrease of contraceptive effect Fosphenytoin This product may cause a slight decrease of contraceptive effect Griseofulvin This product may cause a slight decrease of contraceptive effect Heptabarbital This product may cause a slight decrease of contraceptive effect Hexobarbital This product may cause a slight decrease of contraceptive effect Mephenytoin This product may cause a slight decrease of contraceptive effect Methohexital This product may cause a slight decrease of contraceptive effect Methylphenobarbital This product may cause a slight decrease of contraceptive effect Pentobarbital This product may cause a slight decrease of contraceptive effect Phenobarbital This product may cause a slight decrease of contraceptive effect Phenytoin This product may cause a slight decrease of contraceptive effect Primidone This product may cause a slight decrease of contraceptive effect Rifabutin This product may cause a slight decrease of contraceptive effect Rifampin This product may cause a slight decrease of contraceptive effect Rifapentine This product may cause a slight decrease of contraceptive effect Secobarbital This product may cause a slight decrease of contraceptive effect Talbutal This product may cause a slight decrease of contraceptive effect Amoxicillin This anti-infectious agent could decrease the effect of the oral contraceptive Ampicillin This anti-infectious agent could decrease the effect of the oral contraceptive Azlocillin This anti-infectious agent could decrease the effect of the oral contraceptive Aztreonam This anti-infectious agent could decrease the effect of the oral contraceptive Bacampicillin This anti-infectious agent could decrease the effect of the oral contraceptive Carbenicillin This anti-infectious agent could decrease the effect of the oral contraceptive Clavulanate This anti-infectious agent could decrease the effect of the oral contraceptive Cloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive Cyclacillin This anti-infectious agent could decrease the effect of the oral contraceptive Demeclocycline This anti-infectious agent could decrease the effect of the oral contraceptive Dicloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive Doxycycline This anti-infectious agent could decrease the effect of the oral contraceptive Flucloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive Hetacillin This anti-infectious agent could decrease the effect of the oral contraceptive Penicillin G This anti-infectious agent could decrease the effect of the oral contraceptive Penicillin V This anti-infectious agent could decrease the effect of the oral contraceptive Oxytetracycline This anti-infectious agent could decrease the effect of the oral contraceptive Oxacillin This anti-infectious agent could decrease the effect of the oral contraceptive Nafcillin This anti-infectious agent could decrease the effect of the oral contraceptive Minocycline This anti-infectious agent could decrease the effect of the oral contraceptive Mezlocillin This anti-infectious agent could decrease the effect of the oral contraceptive Meticillin This anti-infectious agent could decrease the effect of the oral contraceptive Methacycline This anti-infectious agent could decrease the effect of the oral contraceptive Itraconazole This anti-infectious agent could decrease the effect of the oral contraceptive Ketoconazole This anti-infectious agent could decrease the effect of the oral contraceptive Piperacillin This anti-infectious agent could decrease the effect of the oral contraceptive Pivampicillin This anti-infectious agent could decrease the effect of the oral contraceptive Rolitetracycline This anti-infectious agent could decrease the effect of the oral contraceptive Tazobactam This anti-infectious agent could decrease the effect of the oral contraceptive Tetracycline This anti-infectious agent could decrease the effect of the oral contraceptive Ticarcillin This anti-infectious agent could decrease the effect of the oral contraceptive Amprenavir Ritonavir could decrease the contraceptive efficacy Nelfinavir Ritonavir could decrease the contraceptive efficacy Ritonavir Ritonavir could decrease the contraceptive efficacy Anisindione Increased thrombotic risk due to estrogen Dicumarol Increased thrombotic risk due to estrogen Acenocoumarol Increased thrombotic risk due to estrogen Warfarin Increased thrombotic risk due to estrogen Aprepitant Aprepitant could decrease the effect of the oral contraceptive Bosentan Bosentan decreases the effect of contraceptive Cyclosporine The contraceptive increases the effect and toxicity of cyclosporine Etoricoxib Etoricoxib increases the levels of ethinyl estradiol Lamotrigine The oral contraceptive decreases the effect of lamotrigine Modafinil Modafinil decreases the effect of contraceptive Oxcarbazepine Oxcarbazepine decreases the effect of the contracepitve Pioglitazone Possible loss of contracepitve effect Troglitazone Possible loss of contracepitve effect Prednisolone The estrogenic agent increases the effect of corticosteroid Prednisone The estrogenic agent increases the effect of corticosteroid Raloxifene Association not recommended St. John's Wort St. John's Wort could reduce the contraceptive effect Tizanidine The contraceptive increases the effect of tizanidine Topiramate Topiramate decreases the effect of estrogen Ursodeoxycholic acid Estrogens decreases the effect of ursodiol

Food Interactions:

Microfollin Chemical Formula:



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Natm Buying Corporation Announces Hire Of New Executive Director, Satoren

NATM Buying Corporation Announces Hire of New Executive Director

August 21, 2014 03:35 PM Eastern Daylight Time

SMITHTOWN, N. Y.--( BUSINESS WIRE )--NATM Buying Corporation, a national buying co-op representing 10 regional retailers in the appliance and electronics industry, announced today the hiring of Gerald (Jerry) Satoren as the organization’s new executive director after an extensive, nationwide search. In his new position, Satoren will help lead the buying group of large regional appliance and electronics retailers.

Founded in 1970, NATM Buying Corporation (NATM) coordinates the buying and merchandising strategies for its members, and provides a forum for the exchange of ideas. Over the years, NATM has been recognized as the leading buying group in the industry.

“We are excited about the future of NATM and its members,” said Scott Hymas, CEO of RC Willey Home Furnishings and NATM member. “NATM’s leadership will be embarking on an expansion plan to bring additional members into the group to complete its national footprint. Jerry will be instrumental in this expansion and will help us take NATM to the next level. He is absolutely the right person for the job.”

Currently, NATM members include Abt Electronics & Appliances, ABC Warehouse, BrandsMart USA, Cowboy Maloney’s Electric City, Curacao, Electronic Express, Nebraska Furniture Mart, P. C. Richard & Son, RC Willey Home Furnishings and Video Only.

“To be asked to represent a group of the largest and finest retailers in America is an opportunity for which I am most honored and grateful,” said Satoren. “I look forward to providing the leadership to help our members continue on the path of prosperous growth and to ensure that the NATM brand continues to be synonymous with only the biggest and the best.”

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Clopidogrel - Fda Prescribing Information, Side Effects And Uses, Klopidogrel

Clopidogrel

WARNING: DIMINISHED EFFECTIVENESS IN POOR METABOLIZERS

The effectiveness of Clopidogrel is dependent on its activation to an active metabolite by the cytochrome P450 (CYP) system, principally CYP2C19 [see Warnings and Precautions (5.1) ]. Clopidogrel at recommended doses forms less of that metabolite and has a smaller effect on platelet function in patients who are CYP2C19 poor metabolizers. Poor metabolizers with acute coronary syndrome or undergoing percutaneous coronary intervention treated with Clopidogrel at recommended doses exhibit higher cardiovascular event rates than do patients with normal CYP2C19 function. Tests are available to identify a patient’s CYP2C19 genotype; these tests can be used as an aid in determining therapeutic strategy [see Clinical Pharmacology (12.5) ]. Consider alternative treatment or treatment strategies in patients identified as CYP2C19 poor metabolizers [see Dosage and Administration (2.3) ].

Indications and Usage for Clopidogrel

Acute Coronary Syndrome (ACS)

• For patients with non-ST-segment elevation ACS [unstable angina (UA)/non-ST-elevation myocardial infarction (NSTEMI)], including patients who are to be managed medically and those who are to be managed with coronary revascularization, Clopidogrel has been shown to decrease the rate of a combined endpoint of cardiovascular death, myocardial infarction (MI), or stroke as well as the rate of a combined endpoint of cardiovascular death, MI, stroke, or refractory ischemia. • For patients with ST-elevation myocardial infarction (STEMI), Clopidogrel has been shown to reduce the rate of death from any cause and the rate of a combined endpoint of death, re-infarction, or stroke. The benefit for patients who undergo primary percutaneous coronary intervention is unknown.

The optimal duration of Clopidogrel therapy in ACS is unknown.

Recent MI, Recent Stroke, or Established Peripheral Arterial Disease

For patients with a history of recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease, Clopidogrel has been shown to reduce the rate of a combined endpoint of new ischemic stroke (fatal or not), new MI (fatal or not), and other vascular death.

Clopidogrel Dosage and Administration

Acute Coronary Syndrome

Clopidogrel can be administered with or without food [see Clinical Pharmacology (12.3) ] .

• For patients with non-ST-elevation ACS (UA/NSTEMI), initiate Clopidogrel with a single 300 mg oral loading dose and then continue at 75 mg once daily. Initiate aspirin (75 to 325 mg once daily) and continue in combination with Clopidogrel [see Clinical Studies (14.1) ]. • For patients with STEMI, the recommended dose of Clopidogrel is 75 mg once daily orally, administered in combination with aspirin (75 to 325 mg once daily), with or without thrombolytics. Clopidogrel may be initiated with or without a loading dose [see Clinical Studies (14.1) ].

Recent MI, Recent Stroke, or Established Peripheral Arterial Disease

The recommended daily dose of Clopidogrel is 75 mg once daily orally, with or without food [see Clinical Pharmacology (12.3) ] .

CYP2C19 Poor Metabolizers

CYP2C19 poor metabolizer status is associated with diminished antiplatelet response to Clopidogrel. Although a higher dose regimen in poor metabolizers increases antiplatelet response [see Clinical Pharmacology (12.5) ]. an appropriate dose regimen for this patient population has not been established.

Use with Proton Pump Inhibitors (PPI)

Avoid using omeprazole or esomeprazole with Clopidogrel. Omeprazole and esomeprazole significantly reduce the antiplatelet activity of Clopidogrel. When concomitant administration of a PPI is required, consider using another acid-reducing agent with minimal or no CYP2C19 inhibitory effect on the formation of Clopidogrel active metabolite [see Warnings and Precautions (5.1). Drug Interactions (7.1) and Clinical Pharmacology (12.3) ].

Dosage Forms and Strengths

• 75 mg tablets: Pink colored, Round shaped, biconvex, film coated tablets de-bossed on one side with SG and 124 on other side. • 300 mg tablets: Pink colored, Modified oval shaped, film coated tablets de-bossed on one side with SG and 121 on other side.

Contraindications

Active Bleeding

Clopidogrel is contraindicated in patients with active pathological bleeding such as peptic ulcer or intracranial hemorrhage.

Hypersensitivity

Clopidogrel is contraindicated in patients with hypersensitivity (e. g. anaphylaxis) to Clopidogrel or any component of the product [see Adverse Reactions (6.2) ] .

Warnings and Precautions

Diminished Antiplatelet Activity Due to Impaired CYP2C19 Function

Clopidogrel is a prodrug. Inhibition of platelet aggregation by Clopidogrel is achieved through an active metabolite. The metabolism of Clopidogrel to its active metabolite can be impaired by genetic variations in CYP2C19 [see Boxed Warning ] and by concomitant medications that interfere with CYP2C19.

Proton Pump Inhibitors

Avoid concomitant use of Clopidogrel with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Clopidogrel [see Drug Interactions (7.1) and Dosage and Administration (2.4) ].

General Risk of Bleeding

Thienopyridines, including Clopidogrel, increase the risk of bleeding. If a patient is to undergo surgery and an antiplatelet effect is not desired, discontinue Clopidogrel five days prior to surgery. In patients who stopped therapy more than five days prior to CABG the rates of major bleeding were similar (event rate 4.4% Clopidogrel + aspirin; 5.3% placebo + aspirin). In patients who remained on therapy within five days of CABG, the major bleeding rate was 9.6% for Clopidogrel + aspirin, and 6.3% for placebo + aspirin.

Thienopyridines inhibit platelet aggregation for the lifetime of the platelet (7 to 10 days), so withholding a dose will not be useful in managing a bleeding event or the risk of bleeding associated with an invasive procedure. Because the half-life of Clopidogrel’s active metabolite is short, it may be possible to restore hemostasis by administering exogenous platelets; however, platelet transfusions within 4 hours of the loading dose or 2 hours of the maintenance dose may be less effective.

Discontinuation of Clopidogrel

Avoid lapses in therapy, and if Clopidogrel must be temporarily discontinued, restart as soon as possible. Premature discontinuation of Clopidogrel may increase the risk of cardiovascular events.

Patients with Recent Transient Ischemic Attack (TIA) or Stroke

In patients with recent TIA or stroke who are at high risk for recurrent ischemic events, the combination of aspirin and Clopidogrel has not been shown to be more effective than Clopidogrel alone, but the combination has been shown to increase major bleeding.

Thrombotic Thrombocytopenic Purpura (TTP)

TTP, sometimes fatal, has been reported following use of Clopidogrel, sometimes after a short exposure (<2 weeks). TTP is a serious condition that requires urgent treatment including plasmapheresis (plasma exchange). It is characterized by thrombocytopenia, microangiopathic hemolytic anemia (schistocytes [fragmented RBCs] seen on peripheral smear), neurological findings, renal dysfunction, and fever [see Adverse Reactions (6.2) ] .

Cross-Reactivity among Thienopyridines

Hypersensitivity including rash, angioedema or hematologic reaction have been reported in patients receiving Clopidogrel, including patients with a history of hypersensitivity or hematologic reaction to other thienopyridines [see Contraindications (4.2) and Adverse Reactions (6.2) ].

Adverse Reactions

The following serious adverse reactions are discussed below and elsewhere in the labeling:

Clinical Studies Experience

Because clinical trials are conducted under widely varying conditions and durations of follow up, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Clopidogrel has been evaluated for safety in more than 54,000 patients, including over 21,000 patients treated for 1 year or more. The clinically important adverse reactions observed in trials comparing Clopidogrel plus aspirin to placebo plus aspirin and trials comparing Clopidogrel alone to aspirin alone are discussed below.

CURE

In CURE, Clopidogrel use with aspirin was associated with an increase in major bleeding (primarily gastrointestinal and at puncture sites) compared to placebo with aspirin (see Table 1). The incidence of intracranial hemorrhage (0.1%) and fatal bleeding (0.2%) were the same in both groups. Other bleeding events that were reported more frequently in the Clopidogrel group were epistaxis, hematuria, and bruise.

The overall incidence of bleeding is described in Table 1.

Table 1: CURE Incidence of Bleeding Complications (% Patients)

* Other standard therapies were used as appropriate. † Life-threatening and other major bleeding. ‡ Major bleeding event rate for Clopidogrel + aspirin was dose-dependent on aspirin: < 100mg = 2.6%; 100 mg to 200 mg = 3.5%; >200 mg = 4.9% Major bleeding event rates for Clopidogrel + aspirin by age were: <65 years = 2.5%,≥ 65 to <75 years = 4.1%, ≥75 years = 5.9% § Major bleeding event rate for placebo + aspirin was dose-dependent on aspirin: <100 mg = 2.0%; 100 mg to 200 mg = 2.3%; >200 mg = 4.0% Major bleeding event rates for placebo + aspirin by age were: <65 years = 2.1%, ≥65 to <75 years = 3.1%, ≥75 years = 3.6% ¶ Led to interruption of study medication

* Major bleeds were cerebral bleeds or non-cerebral bleeds thought to have caused death or that required transfusion.

** The relative rate of major noncerebral or cerebral bleeding was independent of age. Event rates for Clopidogrel + aspirin by age were: <60 years = 0.3%, ≥60 to <70 years = 0.7%,≥ 70 years = 0.8%. Event rates for placebo + aspirin by age were: <60 years = 0.4%, ≥60 to <70 years = 0.6%, ≥70 years = 0.7%.

CAPRIE (Clopidogrel vs. Aspirin)

In CAPRIE, gastrointestinal hemorrhage occurred at a rate of 2.0% in those taking Clopidogrel vs. 2.7% in those taking aspirin; bleeding requiring hospitalization occurred in 0.7% and 1.1%, respectively. The incidence of intracranial hemorrhage was 0.4% for Clopidogrel compared to 0.5% for aspirin.

Other bleeding events that were reported more frequently in the Clopidogrel group were epistaxis and hematoma.

Other Adverse Events

In CURE and CHARISMA, which compared Clopidogrel plus aspirin to aspirin alone, there was no difference in the rate of adverse events (other than bleeding) between Clopidogrel and placebo.

In CAPRIE, which compared Clopidogrel to aspirin, pruritus was more frequently reported in those taking Clopidogrel. No other difference in the rate of adverse events (other than bleeding) was reported.

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of Clopidogrel. Because these reactions are reported voluntarily from a population of an unknown size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

• Blood and lymphatic system disorders: Agranulocytosis, aplastic anemia/pancytopenia, thrombotic thrombocytopenic purpura (TTP), acquired hemophilia A • Eye disorders: Eye (conjunctival, ocular, retinal) bleeding • Gastrointestinal disorders: Gastrointestinal and retroperitoneal hemorrhage with fatal outcome, colitis (including ulcerative or lymphocytic colitis), pancreatitis, stomatitis, gastric/duodenal ulcer, diarrhea • General disorders and administration site condition: Fever, hemorrhage of operative wound • Hepato-biliary disorders: Acute liver failure, hepatitis (non-infectious), abnormal liver function test • Immune system disorders: Hypersensitivity reactions, anaphylactoid reactions, serum sickness • Musculoskeletal, connective tissue and bone disorders: Musculoskeletal bleeding, myalgia, arthralgia, arthritis • Nervous system disorders: Taste disorders, fatal intracranial bleeding, headache • Psychiatric disorders: Confusion, hallucinations • Respiratory, thoracic and mediastinal disorders: Bronchospasm, interstitial pneumonitis, respiratory tract bleeding, eosinophilic pneumonia • Renal and urinary disorders: Increased creatinine levels • Skin and subcutaneous tissue disorders: Maculopapular, erythematous or exfoliative rash, urticaria, bullous dermatitis, eczema, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis (AGEP), angioedema, drug-induced hypersensitivity syndrome, drug rash with eosinophilia and systemic symptoms (DRESS), erythema multiforme, skin bleeding, lichen planus, generalized pruritus • Vascular disorders: Vasculitis, hypotension

Drug Interactions

CYP2C19 Inhibitors

Clopidogrel is metabolized to its active metabolite in part by CYP2C19. Concomitant use of certain drugs that inhibit the activity of this enzyme results in reduced plasma concentrations of the active metabolite of Clopidogrel and a reduction in platelet inhibition [see Warnings and Precautions (5.1) and Dosage and Administration (2.4) ] .

Proton Pump Inhibitors (PPI)

Avoid concomitant use of Clopidogrel with omeprazole or esomeprazole. In clinical studies, omeprazole was shown to reduce the antiplatelet activity of Clopidogrel when given concomitantly or 12 hours apart. A higher dose regimen of Clopidogrel concomitantly administered with omeprazole increases antiplatelet response; an appropriate dose regimen has not been established. A similar reduction in antiplatelet activity was observed with esomeprazole when given concomitantly with Clopidogrel. Consider using another acid-reducing agent with minimal or no CYP2C19 inhibitory effect on the formation of Clopidogrel active metabolite. Dexlansoprazole, lansoprazole and pantoprazole had less effect on the antiplatelet activity of Clopidogrel than did omeprazole or esomeprazole [see Dosage and Administration (2.4). Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ] .

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Coadministration of Clopidogrel and NSAIDs increases the risk of gastrointestinal bleeding.

Warfarin (CYP2C9 Substrates)

Although the administration of Clopidogrel 75 mg per day did not modify the pharmacokinetics of S-warfarin (a CYP2C9 substrate) or INR in patients receiving long-term warfarin therapy, coadministration of Clopidogrel with warfarin increases the risk of bleeding because of independent effects on hemostasis.

However, at high concentrations in vitro. Clopidogrel inhibits CYP2C9.

SSRIs and SNRIs

Since selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) affect platelet activation, the concomitant administration of SSRIs and SNRIs with Clopidogrel may increase the risk of bleeding.

USE IN SPECIFIC POPULATIONS

Pregnancy

Pregnancy Category B

Reproduction studies performed in rats and rabbits at doses up to 500 and 300 mg/kg/day, respectively (65 and 78 times the recommended daily human dose, respectively, on a mg/m 2 basis), revealed no evidence of impaired fertility or fetotoxicity due to Clopidogrel. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of a human response, Clopidogrel should be used during pregnancy only if clearly needed.

Nursing Mothers

Studies in rats have shown that Clopidogrel and/or its metabolites are excreted in the milk. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Clopidogrel, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use

Safety and effectiveness in pediatric populations have not been established.

A randomized, placebo-controlled trial (CLARINET) did not demonstrate a clinical benefit of Clopidogrel in neonates and infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary arterial shunt. Possible factors contributing to this outcome were the dose of Clopidogrel, the concomitant administration of aspirin and the late initiation of therapy following shunt palliation. It cannot be ruled out that a trial with a different design would demonstrate a clinical benefit in this patient population.

Geriatric Use

Of the total number of subjects in the CAPRIE and CURE controlled clinical studies, approximately 50% of patients treated with Clopidogrel were 65 years of age and older, and 15% were 75 years and older. In COMMIT, approximately 58% of the patients treated with Clopidogrel were 60 years and older, 26% of whom were 70 years and older.

The observed risk of bleeding events with Clopidogrel plus aspirin versus placebo plus aspirin by age category is provided in Table 1 and Table 2 for the CURE and COMMIT trials, respectively [see Adverse Reactions (6.1) ]. No dosage adjustment is necessary in elderly patients.

Renal Impairment

Experience is limited in patients with severe and moderate renal impairment [see Clinical Pharmacology (12.2) ] .

Hepatic Impairment

No dosage adjustment is necessary in patients with hepatic impairment [see Clinical Pharmacology (12.2) ] .

Overdosage

Platelet inhibition by Clopidogrel is irreversible and will last for the life of the platelet. Overdose following Clopidogrel administration may result in bleeding complications. A single oral dose of Clopidogrel at 1500 or 2000 mg/kg was lethal to mice and to rats and at 3000 mg/kg to baboons. Symptoms of acute toxicity were vomiting, prostration, difficult breathing, and gastrointestinal hemorrhage in animals.

Based on biological plausibility, platelet transfusion may restore clotting ability.

Clopidogrel Description

Clopidogrel bisulfate is a thienopyridine class inhibitor of P2Y 12 ADP platelet receptors. Chemically it is methyl (+)-( S )-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4 H )-acetate sulfate (1:1). The empirical formula of Clopidogrel bisulfate is C 16 H 16 ClNO 2 S · H 2 SO 4 and its molecular weight is 419.9.

The structural formula is as follows:

Clopidogrel bisulfate, USP is a white to off-white powder. It is freely soluble in methanol, practically insoluble in ether. It has a specific optical rotation of about +56°.

Clopidogrel tablets, USP for oral administration is provided as either pink colored, round shaped, biconvex, de-bossed, film coated tablets containing 97.875 mg of Clopidogrel bisulfate which is the molar equivalent of 75 mg of Clopidogrel base or pink colored, modified oval shaped, de-bossed film coated tablets containing 391.5 mg of Clopidogrel bisulfate which is the molar equivalent of 300 mg of Clopidogrel base.

Each tablet contains microcrystalline cellulose, mannitol, croscarmellose sodium, hydroxy propyl cellulose, hydroxy propyl methyl cellulose and hydrogenated castor oil as inactive ingredients. The film coating contains hypromellose, titanium dioxide, polyethylene glycol and red iron oxide.

Clopidogrel - Clinical Pharmacology

Mechanism of Action

Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y 12 class of ADP receptors on platelets.

Pharmacodynamics

Clopidogrel must be metabolized by CYP450 enzymes to produce the active metabolite that inhibits platelet aggregation. The active metabolite of Clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y 12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. This action is irreversible. Consequently, platelets exposed to Clopidogrel’s active metabolite are affected for the remainder of their lifespan (about 7 to 10 days). Platelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP.

Dose-dependent inhibition of platelet aggregation can be seen 2 hours after single oral doses of Clopidogrel. Repeated doses of 75 mg Clopidogrel per day inhibit ADP-induced platelet aggregation on the first day, and inhibition reaches steady state between Day 3 and Day 7. At steady state, the average inhibition level observed with a dose of 75 mg Clopidogrel per day was between 40% and 60%. Platelet aggregation and bleeding time gradually return to baseline values after treatment is discontinued, generally in about 5 days.

Elderly (≥75 years) and young healthy subjects had similar effects on platelet aggregation.

After repeated doses of 75 mg Clopidogrel per day, patients with severe renal impairment (creatinine clearance from 5 to 15 mL/min) and moderate renal impairment (creatinine clearance from 30 to 60 mL/min) showed low (25%) inhibition of ADP-induced platelet aggregation.

After repeated doses of 75 mg Clopidogrel per day for 10 days in patients with severe hepatic impairment, inhibition of ADP-induced platelet aggregation was similar to that observed in healthy subjects.

In a small study comparing men and women, less inhibition of ADP-induced platelet aggregation was observed in women.

Pharmacokinetics

Clopidogrel is a prodrug and is metabolized to a pharmacologically active metabolite and inactive metabolites.

After single and repeated oral doses of 75 mg per day, Clopidogrel is rapidly absorbed. Absorption is at least 50%, based on urinary excretion of Clopidogrel metabolites.

Effect of Food

Clopidogrel can be administered with or without food. In a study in healthy male subjects when Clopidogrel 75 mg per day was given with a standard breakfast, mean inhibition of ADP-induced platelet aggregation was reduced by less than 9%. The active metabolite AUC 0-24 was unchanged in the presence of food, while there was a 57% decrease in active metabolite C max. Similar results were observed when a Clopidogrel 300 mg loading dose was administered with a high-fat breakfast.

Clopidogrel is extensively metabolized by two main metabolic pathways: one mediated by esterases and leading to hydrolysis into an inactive carboxylic acid derivative (85% of circulating metabolites) and one mediated by multiple cytochrome P450 enzymes. Cytochromes first oxidize Clopidogrel to a 2-oxo-Clopidogrel intermediate metabolite. Subsequent metabolism of the 2-oxo-Clopidogrel intermediate metabolite results in formation of the active metabolite, a thiol derivative of Clopidogrel. This metabolic pathway is mediated by CYP2C19, CYP3A, CYP2B6 and CYP1A2. The active thiol metabolite binds rapidly and irreversibly to platelet receptors, thus inhibiting platelet aggregation for the lifespan of the platelet.

The C max of the active metabolite is twice as high following a single 300 mg Clopidogrel loading dose as it is after four days of 75 mg maintenance dose. C max occurs approximately 30 to 60 minutes after dosing. In the 75 mg to 300 mg dose range, the pharmacokinetics of the active metabolite deviates from dose proportionality: increasing the dose by a factor of four results in 2.0- and 2.7-fold increases in C max and AUC, respectively.

Following an oral dose of 14 C-labeled Clopidogrel in humans, approximately 50% of total radioactivity was excreted in urine and approximately 46% in feces over the 5 days post-dosing. After a single, oral dose of 75 mg, Clopidogrel has a half-life of approximately 6 hours. The half-life of the active metabolite is about 30 minutes.

Clopidogrel is metabolized to its active metabolite in part by CYP2C19. Concomitant use of certain inhibitors of this enzyme results in reduced plasma concentrations of the active metabolite of Clopidogrel and a reduction in platelet inhibition.

Proton Pump Inhibitors (PPI)

The effect of proton pump inhibitors (PPI) on the systemic exposure to the Clopidogrel active metabolite following multiple doses of Clopidogrel 75 mg evaluated in dedicated drug interaction studies is presented in Figure 1.

Figure 1: Exposure to Clopidogrel Active Metabolite Following Multiple Doses of Clopidogrel 75 mg Alone or with Proton Pump Inhibitors (PPIs)

Co-administered PPI Effect on active metabolite AUC Mean and 90% confidence interval

Change relative to Clopidogrel administered alone

Pharmacodynamic and pharmacokinetic parameters measured in these studies showed that the interaction was highest with omeprazole and least with dexlansoprazole.

Pharmacogenomics

CYP2C19 is involved in the formation of both the active metabolite and the 2-oxo-Clopidogrel intermediate metabolite. Clopidogrel active metabolite pharmacokinetics and antiplatelet effects, as measured by ex vivo platelet aggregation assays, differ according to CYP2C19 genotype. Genetic variants of other CYP450 enzymes may also affect the formation of Clopidogrel’s active metabolite.

The CYP2C19*1 allele corresponds to fully functional metabolism while the CYP2C19*2 and *3 alleles are nonfunctional. CYP2C19*2 and *3 account for the majority of reduced function alleles in white (85%) and Asian (99%) poor metabolizers. Other alleles associated with absent or reduced metabolism are less frequent, and include, but are not limited to, CYP2C19*4, *5, *6, *7, and *8. A patient with poor metabolizer status will possess two loss-of-function alleles as defined above. Published frequencies for poor CYP2C19 metabolizer genotypes are approximately 2% for whites, 4% for blacks and 14% for Chinese. Tests are available to determine a patient’s CYP2C19 genotype.

A crossover study in 40 healthy subjects, 10 each in the four CYP2C19 metabolizer groups, evaluated pharmacokinetic and antiplatelet responses using 300 mg followed by 75 mg per day and 600 mg followed by 150 mg per day, each for a total of 5 days. Decreased active metabolite exposure and diminished inhibition of platelet aggregation were observed in the poor metabolizers as compared to the other groups. When poor metabolizers received the 600 mg/150 mg regimen, active metabolite exposure and antiplatelet response were greater than with the 300 mg/75 mg regimen (see Table 3 ). An appropriate dose regimen for this patient population has not been established in clinical outcome trials.

Table 3: Active Metabolite Pharmacokinetics and Antiplatelet Responses by CYP2C19 Metabolizer Status

Some published studies suggest that intermediate metabolizers have decreased active metabolite exposure and diminished antiplatelet effects.

The relationship between CYP2C19 genotype and Clopidogrel treatment outcome was evaluated in retrospective analyses of Clopidogrel-treated subjects in CHARISMA (n=2428) and TRITON-TIMI 38 (n=1477), and in several published cohort studies. In TRITON-TIMI 38 and the majority of the cohort studies, the combined group of patients with either intermediate or poor metabolizer status had a higher rate of cardiovascular events (death, myocardial infarction, and stroke) or stent thrombosis compared to extensive metabolizers. In CHARISMA and one cohort study, the increased event rate was observed only in poor metabolizers.

Nonclinical Toxicology

Carcinogenesis, Mutagenesis, Impairment of Fertility

There was no evidence of tumorigenicity when Clopidogrel was administered for 78 weeks to mice and 104 weeks to rats at dosages up to 77 mg/kg per day, which afforded plasma exposures >25 times that in humans at the recommended daily dose of 75 mg.

Clopidogrel was not genotoxic in four in vitro tests (Ames test, DNA-repair test in rat hepatocytes, gene mutation assay in Chinese hamster fibroblasts, and metaphase chromosome analysis of human lymphocytes) and in one in vivo test (micronucleus test by oral route in mice).

Clopidogrel was found to have no effect on fertility of male and female rats at oral doses up to 400 mg/kg per day (52 times the recommended human dose on a mg/m 2 basis).

Clinical Studies

Acute Coronary Syndrome

The CURE study included 12,562 patients with ACS without ST-elevation (UA or NSTEMI) and presenting within 24 hours of onset of the most recent episode of chest pain or symptoms consistent with ischemia. Patients were required to have either ECG changes compatible with new ischemia (without ST-elevation) or elevated cardiac enzymes or troponin I or T to at least twice the upper limit of normal. The patient population was largely Caucasian (82%) and included 38% women, and 52% patients ≥65 years of age.

Patients were randomized to receive Clopidogrel (300-mg loading dose followed by 75 mg once daily) or placebo, and were treated for up to one year. Patients also received aspirin (75 to 325 mg once daily) and other standard therapies such as heparin. The use of GPIIb/IIIa inhibitors was not permitted for three days prior to randomization.

The number of patients experiencing the primary outcome (CV death, MI, or stroke) was 582 (9.3%) in the Clopidogrel-treated group and 719 (11.4%) in the placebo-treated group, a 20% relative risk reduction (95% CI of 10% to 28%; p < 0.001) for the Clopidogrel-treated group (see Table 4).

Table 4: Outcome Events in the CURE Primary Analysis

Clopidogrel (+ aspirin)* (n=6,259)

Placebo (+ aspirin)* (n=6,303)

Relative Risk Reduction (%) (95% CI)

* Other standard therapies were used as appropriate. † The individual components do not represent a breakdown of the primary and co-primary outcomes, but rather the total number of subjects experiencing an event during the course of the study.

Primary outcome (Cardiovascular death, MI, stroke)

Most of the benefit of Clopidogrel occurred in the first two months, but the difference from placebo was maintained throughout the course of the trial (up to 12 months) (see Figure 2).

Figure 2: Cardiovascular Death, Myocardial Infarction, and Stroke in the CURE Study

In CURE, the use of Clopidogrel was associated with a lower incidence of CV death, MI or stroke in patient populations with different characteristics, as shown in Figure 3. The benefits associated with Clopidogrel were independent of the use of other acute and long-term cardiovascular therapies, including heparin/LMWH, intravenous glycoprotein IIb/IIIa (GPIIb/IIIa) inhibitors, lipid-lowering drugs, beta-blockers, and ACE-inhibitors. The efficacy of Clopidogrel was observed independently of the dose of aspirin (75 mg to 325 mg once daily). The use of oral anticoagulants, non-study antiplatelet drugs, and chronic NSAIDs was not allowed in CURE.

Figure 3: Hazard Ratio for Patient Baseline Characteristics and On-Study Concomitant Medications/Interventions for the CURE Study

The use of Clopidogrel in CURE was associated with a decrease in the use of thrombolytic therapy (71 patients [1.1%] in the Clopidogrel group, 126 patients [2.0%] in the placebo group; relative risk reduction of 43%), and GPIIb/IIIa inhibitors (369 patients [5.9%] in the Clopidogrel group, 454 patients [7.2%] in the placebo group, relative risk reduction of 18%). The use of Clopidogrel in CURE did not affect the number of patients treated with CABG or PCI (with or without stenting), (2253 patients [36.0%] in the Clopidogrel group, 2324 patients [36.9%] in the placebo group; relative risk reduction of 4.0%).

In patients with STEMI, the safety and efficacy of Clopidogrel were evaluated in the randomized, placebo-controlled, double-blind study, COMMIT. COMMIT included 45,852 patients presenting within 24 hours of the onset of the symptoms of myocardial infarction with supporting ECG abnormalities (i. e. ST-elevation, ST-depression or left bundle-branch block).

Patients were randomized to receive Clopidogrel (75 mg once daily) or placebo, in combination with aspirin (162 mg per day), for 28 days or until hospital discharge, whichever came first.

The primary endpoints were death from any cause and the first occurrence of re-infarction, stroke or death.

The patient population included 28% women, 58% age ≥ 60 years (26% age ≥ 70 years), 55% patients who received thrombolytics, 68% who received ACE-inhibitors, and only 3% who underwent PCI.

As shown in Table 5 and Figure 4 and Figure 5 below, Clopidogrel significantly reduced the relative risk of death from any cause by 7% (p=0.029), and the relative risk of the combination of re-infarction, stroke or death by 9% (p=0.002).

Table 5: Outcome Events in the COMMIT Analysis

* The difference between the composite endpoint and the sum of death+non-fatal MI+non-fatal stroke indicates that 9 patients (2 Clopidogrel and 7 placebo) suffered both a non-fatal stroke and a non-fatal MI.

** Non-fatal MI and non-fatal stroke exclude patients who died (of any cause).

Figure 4: Cumulative Event Rates for Death in the COMMIT Study *

* All treated patients received aspirin.

Figure 5: Cumulative Event Rates for the Combined Endpoint Re-Infarction, Stroke or Death in the COMMIT Study*

* All treated patients received aspirin.

The effect of Clopidogrel did not differ significantly in various pre-specified subgroups as shown in Figure 6. The effect was also similar in non-prespecified subgroups including those based on infarct location, Killip class or prior MI history (see Figure 7). Such subgroup analyses should be interpreted cautiously.

Figure 6: Effects of Adding Clopidogrel to Aspirin on the Combined Primary Endpoint across Baseline and Concomitant Medication Subgroups for the COMMIT Study

* Three similar-sized prognostic index groups were based on absolute risk of primary composite outcome for each patient calculated from baseline prognostic variables (excluding allocated treatments) with a Cox regression model.

Figure 7: Effects of Adding Clopidogrel to Aspirin in the Non-Prespecified Subgroups in the COMMIT Study

Recent Myocardial Infarction, Recent Stroke, or Established Peripheral Arterial Disease

The CAPRIE trial was a 19,185-patient, 304-center, international, randomized, double-blind, parallel-group study comparing Clopidogrel (75 mg daily) to aspirin (325 mg daily). The patients randomized had: 1) recent histories of myocardial infarction (within 35 days); 2) recent histories of ischemic stroke (within 6 months) with at least a week of residual neurological signs; or 3) established peripheral arterial disease. Patients received randomized treatment for an average of 1.6 years (maximum of 3 years).

The trial's primary outcome was the time to first occurrence of new ischemic stroke (fatal or not), new myocardial infarction (fatal or not), or other vascular death. Deaths not easily attributable to nonvascular causes were all classified as vascular.

Table 6: Outcome Events in the CAPRIE Primary Analysis

As shown in Table 6, Clopidogrel was associated with a lower incidence of outcome events, primarily MI. The overall relative risk reduction (9.8% vs. 10.6%) was 8.7%, p=0.045. Similar results were obtained when all-cause mortality and all-cause strokes were counted instead of vascular mortality and ischemic strokes (risk reduction 6.9%). In patients who survived an on-study stroke or myocardial infarction, the incidence of subsequent events was lower in the Clopidogrel group.

The curves showing the overall event rate are shown in Figure 8. The event curves separated early and continued to diverge over the 3-year follow-up period.

Figure 8: Fatal or Non-Fatal Vascular Events in the CAPRIE Study

The statistical significance favoring Clopidogrel over aspirin was marginal (p=0.045). However, because aspirin is itself effective in reducing cardiovascular events in patients with recent myocardial infarction or stroke, the effect of Clopidogrel is substantial.

The CAPRIE trial included a population that was randomized on the basis of 3 entry criteria. The efficacy of Clopidogrel relative to aspirin was heterogeneous across these randomized subgroups (p=0.043). It is not clear whether this difference is real or a chance occurrence. Although the CAPRIE trial was not designed to evaluate the relative benefit of Clopidogrel over aspirin in the individual patient subgroups, the benefit appeared to be strongest in patients who were enrolled because of peripheral vascular disease (especially those who also had a history of myocardial infarction) and weaker in stroke patients. In patients who were enrolled in the trial on the sole basis of a recent myocardial infarction, Clopidogrel was not numerically superior to aspirin.

Lack of Established Benefit of Clopidogrel plus Aspirin in Patients with Multiple Risk Factors or Established Vascular Disease

The CHARISMA trial was a 15,603 subject, randomized, double-blind, parallel group study comparing Clopidogrel (75 mg daily) to placebo for prevention of ischemic events in patients with vascular disease or multiple risk factors for atherosclerosis. All subjects were treated with aspirin 75 mg to 162 mg daily. The mean duration of treatment was 23 months. The study failed to demonstrate a reduction in the occurrence of the primary endpoint, a composite of CV death, MI, or stroke. A total of 534 (6.9%) patients in the Clopidogrel group versus 573 (7.4%) patients in the placebo group experienced a primary outcome event (p=0.22). Bleeding of all severities was more common in the subjects randomized to Clopidogrel.

How Supplied/Storage and Handling

Clopidogrel tablets, USP 75 mg are available as pink colored, round shaped, biconvex, film coated tablets de-bossed on one side with SG and 124 on other side. They are available as follows:

NDC 42543-713-30: Bottles of 30 tablets

NDC 42543-713-90: Bottles of 90 tablets

NDC 42543-713-01: Bottles of 100 tablets

NDC 42543-713-05: Bottles of 500 tablets

NDC 42543-713-10: Bottles of 1000 tablets

Clopidogrel tablets, USP 300 mg are available as pink colored, modified oval shaped, film coated tablets de-bossed on one side with SG and 121 on other side. They are available as follows:

NDC 42543-714-30: Bottles of 30 tablets

NDC 42543-714-90: Bottles of 90 tablets

NDC 42543-714-01: Bottles of 100 tablets

NDC 42543-714-05: Bottles of 500 tablets

Store at 20° to 25°C (68° to 77° F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].

PHARMACIST: Dispense a Medication Guide with each prescription.

Patient Counseling Information

Benefits and Risks

• Summarize the effectiveness features and potential side effects of Clopidogrel. • Tell patients to take Clopidogrel exactly as prescribed. • Remind patients not to discontinue Clopidogrel without first discussing it with the physician who prescribed Clopidogrel.

Bleeding

Inform patients that they:

• will bruise and bleed more easily. • will take longer than usual to stop bleeding. • should report any unanticipated, prolonged, or excessive bleeding, or blood in their stool or urine.

Other Signs and Symptoms Requiring Medical Attention

• Inform patients that TTP is a rare but serious condition that has been reported with Clopidogrel and other drugs in this class of drugs. • Instruct patients to get prompt medical attention if they experience any of the following symptoms that cannot otherwise be explained: fever, weakness, extreme skin paleness, purple skin patches, yellowing of the skin or eyes, or neurological changes.

Invasive Procedures

Instruct patients to:

• inform physicians and dentists that they are taking Clopidogrel before any invasive procedure is scheduled. • tell the doctor performing the invasive procedure to talk to the prescribing health care professional before stopping Clopidogrel.

Concomitant Medications

Ask patients to list all prescription medications, over-the-counter medications, or dietary supplements they are taking or plan to take [ see Warnings and Precautions (5) and Drug Interactions (7) ].

Coumadin® is a registered trademark of Bristol-Myers Squibb Pharma Company.

Prilosec® and Nexium® are registered trademark of AstraZeneca.

Jantoven® is a registered trademark of USL Pharma.

Manufactured for: Vensun Pharmaceuticals, Inc. Yardley, PA 19067

Manufactured by: ScieGen Pharmaceuticals, Inc. Hauppauge, NY 11788 USA

Rev. 02, April 2016

MEDICATION GUIDE Clopidogrel (kloe pid′ oh grel) TABLETS, USP 75 mg and 300 mg

Read this Medication Guide before you start taking Clopidogrel tablets and each time you get a refill. There may be new information. This Medication Guide does not take the place of talking with your doctor about your medical condition or your treatment.

What is the most important information I should know about Clopidogrel tablets?

1. Clopidogrel tablets may not work as well in people who:

• have certain genetic factors that affect how the body breaks down Clopidogrel. Your doctor may do genetic tests to make sure Clopidogrel tablets are right for you. • take certain medicines, especially omeprazole (Prilosec ® ) or esomeprazole (Nexium ® ). Your doctor may change the medicine you take for stomach acid problems while you take Clopidogrel tablets.

2. Clopidogrel tablets can cause bleeding which can be serious and can sometimes lead to death. Clopidogrel is a blood thinner medicine that lowers the chance of blood clots forming in your body. While you take Clopidogrel tablets:

• you may bruise and bleed more easily • you are more likely to have nose bleeds • it will take longer for any bleeding to stop

Call your doctor right away if you have any of these signs or symptoms of bleeding:

• unexpected bleeding or bleeding that lasts a long time • blood in your urine (pink, red or brown urine) • red or black stools (looks like tar) • bruises that happen without a known cause or get larger • cough up blood or blood clots • vomit blood or your vomit looks like coffee grounds

Do not stop taking Clopidogrel tablets without talking to the doctor who prescribes it for you. People who stop taking Clopidogrel tablets too soon have a higher risk of having a heart attack or dying. If you must stop Clopidogrel tablets because of bleeding, your risk of a heart attack may be higher.

What are Clopidogrel tablets?

Clopidogrel tablets are a prescription medicine used to treat people who have any of the following:

• chest pain due to heart problems • poor circulation in their legs (peripheral arterial disease) • a heart attack • a stroke

Clopidogrel tablets are used alone or with aspirin to lower your chance of having another serious problem with your heart or blood vessels such as heart attack, stroke, or blood clot that can lead to death.

Platelets are blood cells that help your blood clot normally. Clopidogrel tablets help to prevent platelets from sticking together and forming a clot that can block an artery.

It is not known if Clopidogrel tablets are safe and effective in children.

Who should not take Clopidogrel tablets?

Do not take Clopidogrel tablets if you:

• currently have a condition that causes bleeding, such as a stomach ulcer • are allergic to Clopidogrel or other ingredients in Clopidogrel tablets. See the end of this leaflet for a complete list of ingredients in Clopidogrel tablets.

What should I tell my doctor before taking Clopidogrel tablets?

Before you take Clopidogrel tablets, tell your doctor if you:

• have a history of bowel (gastrointestinal) or stomach ulcers • have a history of bleeding problems • plan to have surgery or a dental procedure. See “How should I take Clopidogrel tablets?” • are pregnant or plan to become pregnant. It is not known if Clopidogrel tablets will harm your unborn baby • are breastfeeding or plan to breastfeed. It is not known if Clopidogrel passes into your breast milk. You and your doctor should decide if you will take Clopidogrel tablets or breastfeed. You should not do both without talking to your doctor. • have had an allergy or reaction to any medicine used to treat your disease.

Tell all of your doctors and your dentist that you are taking Clopidogrel tablets. They should talk to the doctor who prescribed Clopidogrel tablets for you before you have any surgery or invasive procedure.

Tell your doctor about all the medicines you take. including prescription, non-prescription medicines, vitamins and herbal supplements.

Clopidogrel tablets may affect the way other medicines work, and other medicines may affect how Clopidogrel tablets works. See “What is the most important information I should know about Clopidogrel tablets?”

Taking Clopidogrel tablets with certain other medicines may increase your risk of bleeding.

Especially tell your doctor if you take :

• aspirin, especially if you have had a stroke. Always talk to your doctor about whether you should take aspirin along with Clopidogrel tablets to treat your condition. • Non-steroidal anti-inflammatory drugs (NSAIDs). Ask your doctor or pharmacist for a list of NSAID medicines if you are not sure. • warfarin (Coumadin ®. Jantoven ® ) • selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs). Ask your doctor or pharmacist for a list of SSRI or SNRI medicines if you are not sure.

Know the medicines you take. Keep a list of them to show your doctor or pharmacist when you get a new medicine.

How should I take Clopidogrel tablets?

• Take Clopidogrel tablets exactly as your doctor tells you. • Do not change your dose or stop taking Clopidogrel tablets without talking to your doctor first. Stopping Clopidogrel tablets may increase your risk of heart attack or stroke. • Take Clopidogrel tablets with aspirin as instructed by your doctor. • You can take Clopidogrel tablets with or without food. • If you miss a dose, take Clopidogrel tablets as soon as you remember. If it is almost time for your next dose, skip the missed dose. Take the next dose at your regular time. Do not take 2 doses of Clopidogrel tablets at the same time unless your doctor tells you to. • If you take too much Clopidogrel tablets, call your doctor or go to the nearest emergency room right away. • Talk with your doctor about stopping your Clopidogrel tablets before you have surgery. Your doctor may tell you to stop taking Clopidogrel tablets at least 5 days before you have surgery to avoid excessive bleeding during surgery.

What are the possible side effects of Clopidogrel tablets?

Clopidogrel tablets can cause serious side effects including:

• See “What is the most important information I should know about Clopidogrel tablets?” • A blood clotting problem called Thrombotic Thrombocytopenic Purpura (TTP). TTP can happen with Clopidogrel tablets, USP, sometimes after a short time (less than 2 weeks). TTP is a blood clotting problem where blood clots form in blood vessels; and can happen anywhere in the body. TTP needs to be treated in a hospital right away, because it may cause death. Get medical help right away if you have any of these symptoms and they can not be explained by another medical condition: • purplish spots (called purpura) on the skin or in the mouth (mucous membranes) due to bleeding under the skin • your skin or the whites of your eyes are yellow (jaundice) • you feel tired or weak • your skin looks very pale • fever • fast heart rate or feeling short of breath • headache • speech changes • confusion • coma • stroke • seizure • low amount of urine, or urine that is pink or has blood in it • stomach area (abdominal) pain • nausea, vomiting, or diarrhea • vision changes

Tell your doctor if you have any side effect that bothers you or that does not go away. Tell your doctor if you develop an allergic reaction including skin reactions while taking Clopidogrel tablets.

These are not all the possible side effects of Clopidogrel tablets. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Clopidogrel tablets, USP?

• Store Clopidogrel tablets at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).

Keep Clopidogrel tablets and all medicines out of the reach of children.

General information about Clopidogrel tablets

Medicines are sometimes used for purposes other than those listed in a Medication Guide. Do not take Clopidogrel tablets for a condition for which it was not prescribed. Do not give Clopidogrel tablets to other people, even if they have the same symptoms that you have. It may harm them.

This Medication Guide summarizes the most important information about Clopidogrel tablets. If you would like more information, talk to your doctor. Ask your doctor or pharmacist for information about Clopidogrel tablets that was written for healthcare professionals.

For more information, contact Vensun Pharmaceuticals, Inc. at 1-800-385-1540.

What are the ingredients in Clopidogrel tablets?

Active ingredient: Clopidogrel bisulfate, USP

Inactive ingredients: Tablet: microcrystalline cellulose, mannitol, croscarmellose sodium, hydroxy propyl cellulose, hydroxy propyl methyl cellulose and hydrogenated castor oil

Film coating: Hypromellose, titanium dioxide, polyethylene glycol and red iron oxide.

This Medication Guide has been approved by the U. S. Food and Drug Administration.

Coumadin® is a registered trademark of Bristol-Myers Squibb Pharma Company.

Prilosec® and Nexium® are registered trademark of AstraZeneca.

Jantoven® is a registered trademark of USL Pharma.

Manufactured for: Vensun Pharmaceuticals, Inc. Yardley, PA 19067

Manufactured by: ScieGen Pharmaceuticals, Inc. Hauppauge, NY 11788 USA

Rev. 01, August 2015

PRINCIPAL DISPLAY PANEL

NDC 42543-713-30 30 Tablets

Clopidogrel Bisulfate Tablets, USP 75 mg

PHARMACIST: Dispense the accompanying Medication Guide to each patient.

Rx only VENSUN PHARMACEUTICALS, INC.

PRINCIPAL DISPLAY PANEL

NDC 42543-714-30 30 Tablets

Clopidogrel Bisulfate Tablets, USP 300 mg

PHARMACIST: Dispense the accompanying Medication Guide to each patient.

Rx only VENSUN PHARMACEUTICALS, INC.



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Albenza (Albendazole) Medical Facts From, Albenda

Albenza

What is Albenza (albendazole)?

Albendazole is an anthelmintic (an-thel-MIN-tik) or anti - worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.

Albendazole is used to treat certain infections caused by worms such as pork tapeworm and dog tapeworm.

Albendazole may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Albenza (albendazole)?

Albendazole should not be used during pregnancy, unless there is no alternate treatment. You may need to have a negative pregnancy test before starting this treatment.

What should I discuss with my healthcare provider before taking Albenza (albendazole)?

You should not use this medicine if you are allergic to albendazole, or to similar drugs such as mebendazole (Vermox).

To make sure albendazole is safe for you, tell your doctor if you have:

liver disease; or

bone marrow suppression.

It is not known whether this medicine will harm an unborn baby. Albendazole should not be used during pregnancy, unless there is no alternate treatment. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. Use effective birth control to prevent pregnancy while taking this medicine and for at least 1 month after your treatment ends.

You may need to have a negative pregnancy test before starting this treatment.

It is not known whether albendazole passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take Albenza (albendazole)?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

In a young child (or anyone who is unable to swallow a whole albendazole tablet), the tablet should be crushed or chewed and swallowed with a full glass of water.

You may be given other medicines to prevent certain side effects of albendazole, or certain effects that can result when the parasites die within your body.

Tell your doctor if you have any changes in weight. Albendazole doses are based on weight.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Albendazole will not treat a viral infection such as the flu or a common cold.

Albendazole can weaken your immune system. Your blood may need to be tested often. You will need frequent blood tests (every 2 weeks) to check your liver function.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Albenza (albendazole)?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Albenza (albendazole) side effects

Get emergency medical help if you have signs of an allergic reaction . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

signs of bone marrow suppression--sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing, easy bruising or bleeding; or

liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

stomach pain, nausea, vomiting;

dizziness, spinning sensation;

temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Albenza (albendazole)?

Other drugs may interact with albendazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

More about Albenza (albendazole)

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about albendazole.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 3.02. Revision Date: 2015-09-11, 8:19:42 AM.

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Zovirax (Acyclovir) Dosing, Indications, Interactions, Adverse Effects, And More, Aciclin

acyclovir (Rx) Brand and Other Names: Zovirax

Genital Herpes

Initial treatment: 200 mg PO q4hr while awake (5 times daily) for 10 days or 400 mg PO q8hr for 7-10 days

Intermittent treatment for recurrence: 200 mg PO q4hr while awake (5 times daily) for 5 days; initiate at earliest sign or symptom of recurrence

Chronic suppression for recurrence: 400 mg PO q12hr for up to 12 months; alternatively, 200 mg 3-5 times daily

Herpes Simplex Virus Encephalitis

10-15 mg/kg IV q8hr for 10 days; up to 14-21 days reported

In obese patients, use IBW

Mucocutaneous Herpes Simplex Virus Infection

Treatment in immunocompromised patients

IV: 5 mg/kg q8hr for 7 days; dosing up to 14 days reported

In obese patients, use IBW

PO (off-label): 400 mg q4hr while awake (5 times daily) for 7 days

Herpes Zoster (Shingles)

Acute treatment: 800 mg PO q4hr while awake (5 times daily) for 7-10 days

10 mg/kg IV q8hr for 7 days

In obese patients, use IBW

CrCl 25-50 mL/min: Full recommended IV dose q12hr

CrCl 10-25 mL/min: Full recommended IV dose once daily

CrCl 0-10 mL/min: 50% of recommended IV dose once daily

Varicella Zoster (Chickenpox)

>40 kg (immunocompetent): 800 mg PO q6hr for 5 days

Immunocompromised patients: 10-15 mg/kg IV q8hr for 7-10 days

In obese patients, use IBW

Dosing Modifications

Dose adjustment based on renal clearance and normal dosage regimen

200 mg every 4 hr

0-10 mL/min/1.73 m?: 200 mg q12hr

>10 mL/min/1.73 m?: 200 mg q4hr (five times daily)

400 mg every 12 hr

0-10 mL/min/1.73 m?: 200 mg q12hr

>10 mL/min/1.73 m?: 400 mg q12hr

800 mg every 4 hr

0-10 mL/min/1.73 m?: 800 mg q12hr

10-25 mL/min/1.73 m?: 800 mg q8hr

>25 mL/min/1.73 m?: 800 mg q4hr (five times daily)

Dose adjustment based on dosage form

Renal impairment (IV)

CrCl 25-50 mL/min/1.73 m?: Give recommended dose q12hr

CrCl 10-25 mL/min/1.73 m?: Give recommended dose q24hr

CrCl <10 mL/min/1.73 m?: Give 50% of recommended dose q24hr

Renal impairment (PO)

Normal dosage 200 mg q4hr or 400 mg q12hr and CrCl <10 mL/min/1.73 m?: Decrease to 200 mg q12hr

Normal dosage 800 mg q4hr and CrCl 10-25 mL/min/1.73 m?: Decrease to 800 mg q8hr

Normal dosage 800 mg q4hr and CrCl <10 mL/min/1.73 m?: Decrease to 800 mg q12hr

Herpetic Keratitis (Orphan)

Orphan designation for treatment of herpetic keratitis

Cumulus Pharmaceuticals LLC; 1712 Pioneer Avenue, Suite 1377; Cheyenne, Wyoming 82001

Blood products and protein-containing solutions

Additive: Dobutamine, dopamine, meropenem (?)

Y-site: Amifostine, amsacrine, aztreonam, cefepime, dobutamine, dopamine, fludarabine, foscarnet, gemcitabine, idarubicin, levofloxacin, morphine sulfate (?), ondansetron, piperacillin-tazobactam, sargramostim, vinorelbine

IV Compatibilities

Y-site (partial list): Allopurinol, ampicillin, cefazolin, cimetidine, diphenhydramine, fluconazole, heparin, linezolid, lorazepam, magnesium sulfate, potassium chloride, propofol, trimethoprim-sulfamethoxazole, vancomycin

IV Preparation

Reconstitution: Concentrations >10 mg/mL increase risk of phlebitis; usually recommended not to exceed 7 mg/mL in D5W

IV Administration

Maximum dosage: 20 mg/kg q8hr

For IV infusion only

Avoid rapid infusion; infuse over 1 hour at constant rate to prevent renal damage

Maintain adequate hydration

Check for phlebitis, and rotate infusion sites

Storage

Reconstituted solutions remain stable for 24 hours at room temperature

To prevent precipitation, avoid refrigerating reconstituted solutions

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

View the formulary and any restrictions for each plan.

Manage and view all your plans together – even plans in different states.

Compare formulary status to other drugs in the same class.

Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

This drug is available at the lowest co-pay. Most commonly, these are generic drugs.

This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.

This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.

This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.

This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.

This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.

NOT COVERED – Drugs that are not covered by the plan.

Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.

Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.

Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.

Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

About Medscape Drugs & Diseases

Medscape's clinical reference is the most authoritative and accessible point-of-care medical reference for physicians and healthcare professionals, available online and via all major mobile devices. All content is free.

The clinical information represents the expertise and practical knowledge of top physicians and pharmacists from leading academic medical centers in the United States and worldwide.

The topics provided are comprehensive and span more than 30 medical specialties, covering:

Diseases and Conditions

More than 6000 evidence-based and physician-reviewed disease and condition articles are organized to rapidly and comprehensively answer clinical questions and to provide in-depth information in support of diagnosis, treatment, and other clinical decision-making. Topics are richly illustrated with more than 40,000 clinical photos, videos, diagrams, and radiographic images.

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More than 7100 monographs are provided for prescription and over-the-counter drugs, as well as for corresponding brand-name drugs, herbals, and supplements. Drug images are also included.

Drug Interaction Checker

Our Drug Interaction Checker provides rapid access to tens of thousands of interactions between brand and generic drugs, over-the-counter drugs, and supplements. Check mild interactions to serious contraindications for up to 30 drugs, herbals, and supplements at a time.

Access health plan drug formulary information when looking up a particular drug, and save time and effort for you and your patient. Choose from our complete list of over 1800 insurance plans across all 50 US states. Customize your Medscape account with the health plans you accept, so that the information you need is saved and ready every time you look up a drug on our site or in the Medscape app. Easily compare tier status for drugs in the same class when considering an alternative drug for your patient.

Medscape Reference features 129 medical calculators covering formulas, scales, and classifications. Plus, more than 600 drug monographs in our drug reference include integrated dosing calculators.

Hundreds of image-rich slideshow presentations visually engage and challenge readers while expanding their knowledge of both common and uncommon diseases, case presentations, and current controversies in medicine.

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Aspicam, Aspicam

First make sure you have cmake and git installed:

You might also need gcc/g++ in case it's not already installed, along with some other libraries:

You need the raspberry pi userland libraries:

Build the raspicam library

This will create:

libraspicamcv. a . A static raspberry cam library which provides an opencv like interface

libraspicamcv. so . A shared library of the above

raspicamtest . A small test app which uses the static library. Execute with ./raspicamtest. Press Esc to exit.

Using the static library

Add the include path

Link with the raspicamcv library

Link with the userland libraries:

In your code add #include "RaspiCamCV. h" and replace:

CvCapture -> RaspiCamCvCapture

cvCreateCameraCapture -> raspiCamCvCreateCameraCapture

cvQueryFrame -> raspiCamCvQueryFrame

cvReleaseCapture -> raspiCamCvReleaseCapture

cvGetCaptureProperty -> raspiCamCvGetCaptureProperty

cvSetCaptureProperty does not currently work. Use the raspiCamCvCreateCameraCapture2 method to specify width, height, framerate, bitrate and monochrome settings.

Using the shared library

Example C# can be found here which made this .



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Buy Diatrim 24 - Sulfamethoxazole, Trimethoprim - Online Without Prescriptions, Diatrim 24

Bactrim (Diatrim 24)

Bactrim is used for treating infections caused by certain bacteria. Bactrim is an antibiotic combination containing a sulfonamide antibiotic. It works by killing sensitive bacteria.

Use Bactrim as directed by your doctor.

Take Bactrim by mouth with or without food.

Bactrim works best if it is taken at the same time each day.

Take Bactrim with a full glass of water (8 oz/240 mL). Drinking extra fluids while you are taking Bactrim is recommended. Check with your doctor for instructions.

To clear up your infection completely, take Bactrim for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Bactrim, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Bactrim.

Store Bactrim at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Keep in a tight, light-resistant container. Do not store in the bathroom. Keep Bactrim out of the reach of children and away from pets.

Active Ingredients: Sulfamethoxazole and trimethoprim.

Do NOT use Bactrim if:

you are allergic to any ingredient in Bactrim or to similar medicines

you had a severe allergic reaction to any other sulfonamide (sulfa) medicine (eg, glipizide, hydrochlorothiazide)

you are taking dofetilide

you have anemia caused by low levels of folate in the blood or urinary blockage

you are in week 38 of pregnancy or later (full-term) or you are breast-feeding

the patient is a child younger than 2 months old

you will be receiving a live oral typhoid vaccine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Bactrim. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription (especially seizure medications) or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have liver or kidney problems, blood problems (eg, anemia, porphyria), asthma, or HIV infection

if you have severe allergies, glucose-6-phosphate dehydrogenase deficiency, or an enzyme deficiency

if you are at risk for low levels of folate in the blood (eg, you have alcoholism, you are elderly, you do not absorb nutrients from food properly, you are in a poor nutritional state, you are taking medicine for seizures).

Some medicines may interact with Bactrim. Tell your health care provider if you are taking any other medicines, especially any of the following:

Leucovorin because it may decrease Bactrim's effectiveness

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, hydrochlorothiazide) because they may increase the risk of Bactrim's side effects

Anticoagulants (eg, warfarin) because the risk of bleeding may be increased

Dofetilide because the risk of severe heart problems may be increased

Digoxin, methotrexate, phenytoin, sulfones (eg, dapsone), or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Bactrim

BCG vaccine or oral typhoid vaccine because their effectiveness may be decreased by Bactrim

Cyclosporine because its effectiveness may be decreased and the risk of liver side effects may be increased.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Bactrim may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Bactrim may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Bactrim. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur during treatment or within several months after treatment with Bactrim. Do not treat diarrhea without first checking with your doctor.

Be sure to use Bactrim for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Bactrim only works against bacteria; it does not treat viral infections (eg, the common cold).

Long-term or repeated use of Bactrim may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Diabetes patients - Bactrim may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Bactrim may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Bactrim.

Lab tests, including complete blood cell counts and kidney function, may be performed while you use Bactrim. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Bactrim with caution in the elderly; they may be more sensitive to its effects, especially severe skin reactions, bone marrow suppression, or high blood potassium levels.

Bactrim should not be used in children younger 2 months; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Bactrim while you are pregnant. Do not use Bactrim if you are in week 38 of pregnancy or later (full-term). Bactrim is found in breast milk. Do not breastfeed while taking Bactrim.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Appetite loss; diarrhea; nausea; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); blistered, peeling, red, or swollen skin; bloody or black, tarry stools; chest pain; chills, fever, or sore throat; confusion; dark urine; decreased urination; depression; hallucinations; irregular heartbeat; joint or muscle pain; mental or mood changes; painful or stiff neck; purple patches under the skin; seizures; severe diarrhea; severe or persistent cough; severe or persistent headache; severe or persistent nausea or vomiting; shortness of breath; stomach cramps/pain; unusual bruising or bleeding; unusual tiredness or weakness; unusually pale skin; vaginal irritation or discharge; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Bactrim (Diatrim 24)

Bactrim is used for treating infections caused by certain bacteria. Bactrim is an antibiotic combination containing a sulfonamide antibiotic. It works by killing sensitive bacteria.

Use Bactrim as directed by your doctor.

Take Bactrim by mouth with or without food.

Bactrim works best if it is taken at the same time each day.

Take Bactrim with a full glass of water (8 oz/240 mL). Drinking extra fluids while you are taking Bactrim is recommended. Check with your doctor for instructions.

To clear up your infection completely, take Bactrim for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Bactrim, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Bactrim.

Store Bactrim at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Keep in a tight, light-resistant container. Do not store in the bathroom. Keep Bactrim out of the reach of children and away from pets.

Active Ingredients: Sulfamethoxazole and trimethoprim.

Do NOT use Bactrim if:

you are allergic to any ingredient in Bactrim or to similar medicines

you had a severe allergic reaction to any other sulfonamide (sulfa) medicine (eg, glipizide, hydrochlorothiazide)

you are taking dofetilide

you have anemia caused by low levels of folate in the blood or urinary blockage

you are in week 38 of pregnancy or later (full-term) or you are breast-feeding

the patient is a child younger than 2 months old

you will be receiving a live oral typhoid vaccine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Bactrim. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription (especially seizure medications) or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have liver or kidney problems, blood problems (eg, anemia, porphyria), asthma, or HIV infection

if you have severe allergies, glucose-6-phosphate dehydrogenase deficiency, or an enzyme deficiency

if you are at risk for low levels of folate in the blood (eg, you have alcoholism, you are elderly, you do not absorb nutrients from food properly, you are in a poor nutritional state, you are taking medicine for seizures).

Some medicines may interact with Bactrim. Tell your health care provider if you are taking any other medicines, especially any of the following:

Leucovorin because it may decrease Bactrim's effectiveness

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, hydrochlorothiazide) because they may increase the risk of Bactrim's side effects

Anticoagulants (eg, warfarin) because the risk of bleeding may be increased

Dofetilide because the risk of severe heart problems may be increased

Digoxin, methotrexate, phenytoin, sulfones (eg, dapsone), or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Bactrim

BCG vaccine or oral typhoid vaccine because their effectiveness may be decreased by Bactrim

Cyclosporine because its effectiveness may be decreased and the risk of liver side effects may be increased.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Bactrim may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Bactrim may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Bactrim. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur during treatment or within several months after treatment with Bactrim. Do not treat diarrhea without first checking with your doctor.

Be sure to use Bactrim for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Bactrim only works against bacteria; it does not treat viral infections (eg, the common cold).

Long-term or repeated use of Bactrim may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Diabetes patients - Bactrim may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Bactrim may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Bactrim.

Lab tests, including complete blood cell counts and kidney function, may be performed while you use Bactrim. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Bactrim with caution in the elderly; they may be more sensitive to its effects, especially severe skin reactions, bone marrow suppression, or high blood potassium levels.

Bactrim should not be used in children younger 2 months; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Bactrim while you are pregnant. Do not use Bactrim if you are in week 38 of pregnancy or later (full-term). Bactrim is found in breast milk. Do not breastfeed while taking Bactrim.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Appetite loss; diarrhea; nausea; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); blistered, peeling, red, or swollen skin; bloody or black, tarry stools; chest pain; chills, fever, or sore throat; confusion; dark urine; decreased urination; depression; hallucinations; irregular heartbeat; joint or muscle pain; mental or mood changes; painful or stiff neck; purple patches under the skin; seizures; severe diarrhea; severe or persistent cough; severe or persistent headache; severe or persistent nausea or vomiting; shortness of breath; stomach cramps/pain; unusual bruising or bleeding; unusual tiredness or weakness; unusually pale skin; vaginal irritation or discharge; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Orfix · Cash Packaging, Orfix

ORFIX · CASH PACKAGING

Thinking about cash packaging means thinking about orfix. Our extensive product range of high quality cash packaging products offers solutions which are optimized for use and meet all international standards.

orfix · Cash Packaging

is one of the core capabilities of orfix since 1950. With experience and know how orfix developed together with the German National Bank (Deutsche Bundesbank - BKK) the actual valid standard of requirements for coin and banknote wrappers. In cooperation with the machine manufacturers orfix contributed to the standardization of paper rolls for automatic coin wrapping.

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Krimizole, Krimizole

Krimizole

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Ranibos, Ranibos

Film coated tablets for rapid and efficient removal and prevention of gastric disorders

Composition: Each film ctd tablet contains 75 mg of ranitidine

Action: Active component in its composition inhibits strongly both day and night secretion of gastric acid by blocking the histaminic H2 receptors located in mucous membrane of stomach.

heartburn

acid belching

overfed and heavy stomach sensation

nausea

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acid

Dosage and administration: Adults and children older than 16 years: at onset of disorder it is recommended to take 1 film ctd tablet and in case of more serious disorders and those lasting more than 1 hour 2 film ctd tablets may be taken. For prevention of symptoms caused by intensified excretion of stomach acid it is recommended to administer 1 film ctd tablet 30 minutes to 1 hour before consuming the food and drink supposed to be able to provoke the disorder.

Special warnings: It is not recommended to administer the drug in children below the age of 16. Caution is needed in persons taking concomitantly one or more drugs for other diseases.

Presentation: Bottle containing 30 film ctd tablets

Before use, read carefully the attached instructions for use.

Checked to distinguish fire

Ranitidine is used for treating certain conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It is also used to treat ulcers of the small intestine that have not responded to other treatment. It may be used as a short-term alternative to oral ranitidine, in patients who are not able to take medicine by mouth. Ranitidine is an H 2 - receptor blocker. It works by blocking the action of histamine in the stomach. This reduces the amount of acid the stomach makes. Reducing stomach acid helps to reduce heartburn, heal irritation of the esophagus, and heal ulcers of the stomach or intestines.

Use Ranitidine as directed by your doctor.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

You may take antacids while you are using Ranitidine if you are directed to do so by your doctor.

Continue to use Ranitidine even if you feel well. Do not miss any dose.

If you miss a dose of Ranitidine, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ranitidine.

Store Ranitidine between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ranitidine out of the reach of children and away from pets.

Do NOT use Ranitidine if:

you are allergic to any ingredient in Ranitidine

you have a history of the blood disease porphyria

you are taking dasatinib.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Ranitidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems

if you have abnormal blood electrolyte levels or a history of irregular heartbeat.

Some medicines may interact with Ranitidine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Certain benzodiazepines (eg, midazolam, triazolam), glipizide, procainamide, or warfarin because the risk of their side effects may be increased by Ranitidine

Dasatinib, delavirdine, gefitinib, certain HIV protease inhibitors (eg, atazanavir), itraconazole, or ketoconazole because their effectiveness may be decreased by Ranitidine.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ranitidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Ranitidine may rarely cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ranitidine with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Ranitidine may interfere with certain lab tests, including urine protein tests. Be sure your doctor and lab personnel know you are taking Ranitidine.

Lab tests, including liver function, may be performed while you use Ranitidine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Ranitidine should be used with extreme caution in children younger than 1 month old; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ranitidine while you are pregnant. Ranitidine is found in breast milk. Do not breastfeed while taking Ranitidine.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; headache; nausea; stomach upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); change in the amount of urine produced; confusion; dark urine; depression; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; severe or persistent headache or stomach pain; unusual bruising or bleeding; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Asociacion Nacional De Productores De Leche, Analac

Se informa a todas las personas interesadas en asistir al Congreso de conmemoracion de los 60 anos de ANALAC, que no pudieron hacer oportunamente su registro, que a partir de la 01:00 p. m. se estara haciendo directamente el registro en la Sede Salitre de la Camara de Comercio de Bogota.

El ingreso al evento no tiene ningun costo.

Lugar: Auditorio Camara de Comercio Sede Salitre, Bogota. Avenida El Dorado No. 68D-35 Edificio Sede y Centro Empresarial Salitre

ANALAC Carrera 13 # 33-74…

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Se informa a todas las personas interesadas en asistir al Congreso de conmemoracion de los 60 anos de ANALAC, que no pudieron hacer oportunamente su registro, que a partir de la 01:00 p. m. se estara haciendo directamente el registro en la Sede Salitre de la Camara de Comercio de Bogota.

El ingreso al evento no tiene ningun costo.

Lugar: Auditorio Camara de Comercio Sede Salitre, Bogota. Avenida El Dorado No. 68D-35 Edificio Sede y Centro Empresarial Salitre Informes: ANALAC Carrera 13 # 33-74…

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# CongresoANALAC Se agota el tiempo para realizar su inscripcion, 30 de agosto 2016, envie sus datos personales a contactolechero @analac. org, o comuniquese al telefono: (031) 4838080

Compartimos la agenda del evento.

ASISTA GRATIS A NUESTRO CONGRESO EL PROXIMO 30 DE AGOSTO.

Lugar: Auditorio Camara…

Se informa a todas las personas interesadas en asistir al Congreso de conmemoracion de los 60 anos de ANALAC, que no pudieron hacer oportunamente su registro, que a partir de la 01:00 p. m. se estara haciendo directamente el registro en la Sede Salitre de la Camara de Comercio de Bogota.

El ingreso al evento no tiene ningun costo.

Lugar: Auditorio Camara de Comercio Sede Salitre, Bogota. Avenida El Dorado No. 68D-35 Edificio Sede y Centro Empresarial Salitre

ANALAC Carrera 13 # 33-74…

30 августа в 16:00 · Доступно всем

Se informa a todas las personas interesadas en asistir al Congreso de conmemoracion de los 60 anos de ANALAC, que no pudieron hacer oportunamente su registro, que a partir de la 01:00 p. m. se estara haciendo directamente el registro en la Sede Salitre de la Camara de Comercio de Bogota.

El ingreso al evento no tiene ningun costo.

Lugar: Auditorio Camara de Comercio Sede Salitre, Bogota. Avenida El Dorado No. 68D-35 Edificio Sede y Centro Empresarial Salitre Informes: ANALAC Carrera 13 # 33-74…

29 августа в 23:03 · Доступно всем

# CongresoANALAC Se agota el tiempo para realizar su inscripcion, 30 de agosto 2016, envie sus datos personales a contactolechero @analac. org, o comuniquese al telefono: (031) 4838080

Compartimos la agenda del evento.

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Cremirit, Cremirit

Cada 100 g de CREMA contiene: Betametasona (como dipropionato) 0,05 g.

CONTRAINDICACIONES: Lesiones ulcerosas, acné, rosácea, dermatitis, lesiones de la piel causadas por infecciones virales primarias. Hipersensibilidad a Betametasona u otros corticoides.

REACCIONES ADVERSAS: Sequedad de la piel, ulceraciones de la piel, irritación, prurito, hipopigmentación, adelgazamiento de la piel en forma dolorosa y lenta, piel oscura, enrojecimiento de la piel.

INDICACIONES: Alivio de manifestaciones inflamatorias y pruríticas de las dermatosis que responden a corticoesteroides.

DOSIFICACIÓN: Aplicar una pequeña cantidad de crema sobre el área afectada 1 ó 2 veces al día.

PRESENTACION: Pomo con 15 g de crema.

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Nasonex Nasal Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Mesonex

Nasonex nasal

Uses

Mometasone is used to prevent and treat seasonal and year-round allergy symptoms (such as stuffy/runny nose. itching. and sneezing ). It is also used to treat certain growths in the nose (nasal polyps ). Mometasone belongs to a class of drugs known as corticosteroids. It works by reducing swelling (inflammation ) in the nasal passages.

OTHER USES: This section contains uses of this drug that are not listed in the approved US professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

How to use Nasonex nasal

Read the Patient Information Leaflet if available from your pharmacist before you start using mometasone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Use this medication in the nose as directed by your doctor, usually once a day for runny nose (rhinitis) and once or twice a day for polyps. Do not spray in the eyes or mouth. Gently blow your nose before using this drug. Shake the container well before each use. Follow the instructions to properly prime the spray pump.

To use the spray, remove the protective cap. Close one nostril by pressing it with your finger. Tilt your head slightly forward and, keeping the bottle upright, carefully insert the nasal applicator into the other nostril. Press down firmly on the pump to deliver the prescribed number of sprays. Do not spray directly onto the middle wall of your nose (nasal septum). Breathe in gently through your nose and out through your mouth. Repeat in the other nostril. Wipe the applicator tip and replace the plastic cap. Avoid blowing your nose for 15 minutes after using this medication.

Dosage is based on your medical condition and response to treatment. Younger children may need a smaller dose and help from an adult to use this medication properly. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day. Do not increase your dose or use it more frequently than directed.

This medication does not work right away. Some people will feel this medication working within 2 days, but it may take up to 2 weeks before the full benefit of this drug takes effect. Therefore, when using mometasone to prevent seasonal allergy symptoms, you may need to start this medication 2-4 weeks before pollen season begins. Ask your doctor or pharmacist if you should also use other medications (such as nose drops/spray, allergy drugs taken by mouth ) along with this drug until it takes full effect.

Keep track of the number of sprays used from the container. Discard the container after you have used the number of sprays specified on the manufacturer's package. Follow the package instructions to unblock the spray tip if needed and to clean the spray bottle.

Tell your doctor if your symptoms do not improve after 2 weeks or if they worsen.

Side Effects

See also Precautions.

Nose/throat dryness or irritation, blood - tinged mucus/phlegm, and nosebleeds may occur. If any of these side effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these serious side effects occur: pain/sores in your nose, white patches in your nose/mouth, painful swallowing/trouble swallowing.

Rarely, it is possible that corticosteroids given in the nose will be absorbed into the bloodstream. This can lead to side effects of too much corticosteroid. These side effects are more likely in children and people who use this medication for a long time and in high doses. Tell your doctor right away if any of the following side effects occur: unusual/extreme tiredness, weight loss. headache. swelling ankles /feet, increased thirst/urination, vision problems.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using mometasone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye problems (such as glaucoma. cataracts ), infections (including tuberculosis. herpes eye infection), recent nose problems (such as injury, ulcers, surgery).

Avoid contact with people who have infections that may spread to others (such as chickenpox, measles. flu ). Consult your doctor if you have been exposed to an infection or for more details.

Rarely, using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Though it is unlikely, this medication may slow down a child's growth if used for a long time. The effect on final adult height is unknown. See the doctor regularly so your child's height can be checked.

During pregnancy. this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast - feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Medical examinations (especially of your nose and eyes) should be performed periodically during prolonged use of this medication to monitor your progress or check for side effects. Consult your doctor for more details.

Make sure all of your doctors know that you are using this medication or have used it in the past.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store upright at room temperature away from light and moisture. Do not store in the bathroom. Do not freeze. Keep all medications away from children and pets.

Different brands of this medication may have different storage requirements. Read the package labeling or ask your pharmacist for the storage requirements for the product you are using.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Dilast Tool And Die Ltd, Dilast

at dilast tool and die.

OUR QUALITY POLICY.

Our commitment to quality is the main focus of what we do. In order to maintain our superb reputation in quality production, we have developed a quality-focused company culture structured on ISO standards, customer specifications and our own determination to build the finest tooling available.

As a custom tool shop, our operation is driven by our customer's needs at every stage from quoting and design to delivery. We are proud to service the needs of our customers from small business to Fortune 500.

Suppliers of precision tooling from design to delivery

We specialize in the design and production of precision tooling, primarily for the automotive industry.

We work closely with our customers through all stages of design, production and part development to ensure the finished tooling produces the parts you require, within your timeframe.

We value the longstanding relationships we have developed with our customers by providing continued support for our tooling throughout its production lifespan.

We are proud of our reputation as a high quality supplier of precision tooling, and we will continue to evolve in order to meet and exceed our customer requirements.

Copyright 2011 Dilast Tool & Die Ltd. All rights reserved.

Designed and maintained by admin@dilast. ca

at dilast tool and die.

OUR QUALITY POLICY.

Our commitment to quality is the main focus of what we do. In order to maintain our superb reputation in quality production, we have developed a quality-focused company culture structured on ISO standards, customer specifications and our own determination to build the finest tooling available.

As a custom tool shop, our operation is driven by our customer's needs at every stage from quoting and design to delivery. We are proud to service the needs of our customers from small business to Fortune 500.

Suppliers of precision tooling from design to delivery

We specialize in the design and production of precision tooling, primarily for the automotive industry.

We work closely with our customers through all stages of design, production and part development to ensure the finished tooling produces the parts you require, within your timeframe.

We value the longstanding relationships we have developed with our customers by providing continued support for our tooling throughout its production lifespan.

We are proud of our reputation as a high quality supplier of precision tooling, and we will continue to evolve in order to meet and exceed our customer requirements.

Copyright 2011 Dilast Tool & Die Ltd. All rights reserved.

Designed and maintained by admin@dilast. ca

at dilast tool and die.

OUR QUALITY POLICY.

Our commitment to quality is the main focus of what we do. In order to maintain our superb reputation in quality production, we have developed a quality-focused company culture structured on ISO standards, customer specifications and our own determination to build the finest tooling available.

As a custom tool shop, our operation is driven by our customer's needs at every stage from quoting and design to delivery. We are proud to service the needs of our customers from small business to Fortune 500.

Suppliers of precision tooling from design to delivery

We specialize in the design and production of precision tooling, primarily for the automotive industry.

We work closely with our customers through all stages of design, production and part development to ensure the finished tooling produces the parts you require, within your timeframe.

We value the longstanding relationships we have developed with our customers by providing continued support for our tooling throughout its production lifespan.

We are proud of our reputation as a high quality supplier of precision tooling, and we will continue to evolve in order to meet and exceed our customer requirements.

Copyright 2011 Dilast Tool & Die Ltd. All rights reserved.

Designed and maintained by admin@dilast. ca

at dilast tool and die.

OUR QUALITY POLICY.

Our commitment to quality is the main focus of what we do. In order to maintain our superb reputation in quality production, we have developed a quality-focused company culture structured on ISO standards, customer specifications and our own determination to build the finest tooling available.

As a custom tool shop, our operation is driven by our customer's needs at every stage from quoting and design to delivery. We are proud to service the needs of our customers from small business to Fortune 500.

Suppliers of precision tooling from design to delivery

We specialize in the design and production of precision tooling, primarily for the automotive industry.

We work closely with our customers through all stages of design, production and part development to ensure the finished tooling produces the parts you require, within your timeframe.

We value the longstanding relationships we have developed with our customers by providing continued support for our tooling throughout its production lifespan.

We are proud of our reputation as a high quality supplier of precision tooling, and we will continue to evolve in order to meet and exceed our customer requirements.

Copyright 2011 Dilast Tool & Die Ltd. All rights reserved.

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Relitone, Relitone

Welcome to a better way to do drums.

With RealiDrums, you’ll be working faster, you’ll be getting what we believe are the best sounds available, the most sounds available (with 42 snares, you *will* find what you need), and most importantly, you’ll be having more fun doing it. Yes, seriously.

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Gluvas, Gluvas

Gluvas

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Product Description Common use Amaryl is an oral blood sugar-lowering drug which belongs to the class of sulfonylureas. Active substance is Glimepiride. It is used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes. The mechanism of its action is to stimulate the secretion and release of insulin from beta cells of the pancreas (pancreatic effect). Amaryl is used to treat non-insulin depending diabetes (type 2) as monotherapy or in combination with insulin (or metformin).

Dosage and direction

The best dose is determined by a physician on a basis of regular measurements of blood sugar content.

Be careful your sugar does not fall too low due to stress, skipping a meal, exercising too long, or drinking alcohol. Know signs of hypoglycemia and keep a source of sugar at hand. If your sugar level is too high you may feel very thirsty or hungry. You may also urinate more than usual. Take this medication exactly as prescribed as it is a part of a complicated program consisting of diet, medication, and exercise routines. Tell your doctor if you are pregnant or plan to become pregnant, have adrenal or pituitary gland problems before taking this medication.

Contraindication Amaryl is contraindicated in patients with history of diabetic ketoacidosis, diabetic coma and prekoma, insulin-dependent diabetes (type 1), severe renal dysfunction, severe hepatic impairment, individual hypersensitivity to Amaryl, other members of sulfonylurea class and sulfonamides.

Possible side effect If you have any signs of allergic reaction to this medication such as hives, swelling of face and throat, rash or other major symptoms (severe skin rash, itching, redness, pale skin, easy bruising or bleeding, numbness, dark urine, clay-colored stools, abdominal pain, fever, nausea)seek for immediate medical help.

Drug interaction Diuretics like hydrochlorothiazide (Hydrodiuril, Ezide, Hydro-Par, Microzide, furosemide (Lasix)), corticosteroids such as prednisone and methylprednisolone (Medrol), phenytoin (Dilantin), niacin, and sympathomimetics such as pseudoephedrine (Sudafed) are able to increase blood sugar and diminish effect of Amaryl. Propranolol (Inderal) and atenolol (Tenormin) belong to beta-blockers and also are able to affect blood levels and decrease activity of Amaryl.

Missed dose Take the missed dose as soon as you remember about it. If it is almost time of your next dose just skip it and return to your regular schedule.

Overdose Immediate medical attention is needed in case you took too much medicine. Possible side effects include: extreme weakness, confusion, blurred vision, stomach pain, trouble speaking, tremors, sweating, seizure, and coma.

Storage Store at room temperature in a tight container and keep away from sunlight, moisture, kids and pets.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

. WARNINGS AND PRECAUTIONS.

Careful administration in patients with anemia, gastrointestinal disorders, and asthma.

Caution used in pregnancy, used if it is necessary.

Do not exceed the recommended dose, it may cause liver dysfunction.

Careful administration in patients with renal impairment.

If fever does not improve after 2 days or if there is no relief from pain after 5 days, contact the physician immediately.

Allergic reactions, neutropenia, thrombocytopenia, purpura, nausea, vomiting, gastrointestinal tract disorders.

High-dose or long-term used may cause hepatic impairment.

Lower respiratory tract infections: acute and chronic bronchitis, infected bronchiectasis, bacterial pneumonia, lung abscess and postoperative chest infections.

Urinary tract infections: acute and chronic pyelonephritis, cystitis, asymptomatic bacteriuria.

Soft tissue infection: cellulitis, erysipelas, peritonitis and wound infections.

Bone and joint infection: osteomyelitis.

Obstetric and gynecological infection: pelvic inflammatory disease.

Gonorrhoea, particularly if penicillin is unsuitable.

Other infections: septicemia and meningitis.

Prophylaxis against infection in abdominal, pelvic, orthopedic, cardiac, pulmonary, esophageal and vascular surgery where there is increased risk from infection.

Patients with known hypersensitivity to cephalosporin antibiotics.

. DOSAGE AND ADMINISTRATIONS.

General dosage Adults: Many infections will respond to 750 mg three times daily by intramuscular or intravenous injection. For more severe infections this dose should be increased to 1.5 gram three times daily intravenously.

Infants and children: Doses of 30 to 100 mg/kg/day given in 3 or 4 divided doses. A dose of 60 mg/kg/day will be appropriate for most infections.

Neonates: Doses of 30 to 100 mg/kg/day given in 2 or 3 divided doses.

Gonorrhoe: 1.5 gram should be given as a single dose or as two 750 mg injections into different sites.

Meningitis Infants and children: 150 to 250 mg/kg/day intravenously in 3 or 4 divided doses. This dosage may be reduced to 100 mg/kg/day after three days or when clinical improvement occurs.

Adults: 3 gram intravenously every eight hours.

Prophylaxis The usual dose is 1.5 gram intravenously with induction of anesthesia. For orthopedic, pelvic and abdominal operations, this may be followed with two 750 mg doses 8 and 16 hours later. For vascular, cardiac, esophageal and pulmonary operations this may be supplemented with 750 mg intramuscularly three times a day for a further 24 to 48 hours.

Dosage in impaired renal function The dosage should be reduced to allow for slower excretion in patients with impaired renal function.

Patients who have experienced an anaphylactic reaction to penicillin.

Patients who receive high dosage of cephalosporin and use potent diuretics (such as furosemide) or aminoglycosides, as these combinations are suspected of adversely affecting renal function.

Pregnant and nursing patients.

Patients with gastrointestinal history, particularly colitis.

Gastrointestinal disturbance: pseudomembranous colitis

Hypersensitivity reaction: skin rashes (maculopapular and urticarial), drug fever and anaphylaxis reaction.

Hematologic reactions: a decrease in hemoglobin concentration, eosinophilia, leukopenia and neutropenia.

Thrombophlebitis may occur at the site of intravenous injection.

. DOSAGE AND ADMINISTRATION.

Treatment of post-operative nausea and vomiting: A single dose of 4 mg IM and 4 mg given by slow intravenous injection is recommended.

Prevention and treatment of nausea and vomiting induced by chemotherapy: Adults:

Highly emetogenic chemotherapy: A dose of 8 mg by slow intravenous injection or as a short-time intravenous infusion over 15 minutes immediately before chemotherapy, followed by a constant infusion of 1 mg/hour for up to 24 hours or 2 further slow intravenous injection doses of 8 mg (over 15 minutes) 4 hours apart, or by oral administration is 8 mg twice daily should be continued for up to 5 days after a course of treatment.

Emetogenic chemotherapy: A dose of 8 mg by slow intravenous injection or as a short-time intravenous infusion over 15 minutes immediately before chemotherapy, followed by per oral 8 mg twice daily should be continued for up to 5 days after a course of treatment.

Children >4 years of age: 5 mg/ml by intravenous infusion over 15 minutes immediately before chemotherapy, followed by per oral 4 mg every 12 hours for less than 5 days.

Elderly: Ondansetron is well tolerated by patients over 65 years and no alteration of dosage, dosing frequency or route of administration are required.

Patients with renal dysfunction: No alteration of daily dosage or frequency of dosing, or route of administration is required.

Patients with hepatic impairment: A total daily dose of 8 mg should not be exceeded.

. WARNINGS AND PRECAUTIONS.

Pregnancy (particularly first trimester of pregnancy) and breast-feeding women.

Children under 2 years old.

Headache, constipation, sensation of warmth or flushing, sedation and diarrhea.

Box, 2 ampoules @ 4 ml. 2 ampoules @ 2 ml.

Each ULSIDEXR tablet contain: Sucralfate (allumunium sucrose sulphate bass) 500 mg

Peptic and duodenal ulcers.

. DOSAGE AND ADMINISTRATION.

Adults . 2 tablets, 3-4 times daily, taken on an empty stomach. *For short term treatment (until 8 weeks).

. WARNINGS AND PRECAUTIONS.

Should be used with caution in patients with impaired renal function.

Pregnancy, lactation, and children.

. PRESENTATION AND REGISTRATION NUMBER.

Box, 10 strips @ 10 tablets;

Should not be used in patients who are sensitive to other sympathomimetics drugs (e. g. ephedrine, phenylpropanolamine, phenylephrine), patients with severe hypertension, and who are receiving monoamine oxidase inhibitor (MAOI) antidepressant therapy.

Do not exceed the recommended dose.

Should be used with caution in patients with hypertension, or who have potentiality to develop hypertension or stroke, such as patients with overweight or elderly patients.

If within 3 days common cold symptoms do not subside, contact your doctor or health care facilities immediately.

Stop using the drug if you experience insomnia, palpitation, and dizziness.

Each 5 ml contains: Pseudoephedrine hydrochloride 15 mg Chlorpheniramine maleate 1 mg

Relieves sneezing, nasal congestion due to the common cold.

See boxed warning. Patients who are hypersensitive to the components of this drug.

. DOSAGE AND ADMINISTRATIONS.

Adults and children older than 12 years of age: 2 measuring spoonful (10 ml), three times daily.

Children 6-12 years of age: 1 measuring spoonful (5 ml), three times daily.

Children 2-5 years of age: 1/2 measuring spoonful (2.5 ml), three times daily.

Children younger than 2 years of age: as directed by a physician.

. WARNING AND PRECAUTIONS.

See boxed warning.

Should be used with caution in patients with liver and kidney dysfunction, glaucoma, prostate hypertrophy, hyperthyroidism, urinary retention, heart disorders, and diabetes mellitus.

It is not recommended for children younger than 2 years of age, pregnant and nursing women, unless as directed by a physician.

When using this product do not drive a motor vehicle or operate machinery.

Should be cautious if used concomitantly with other central nervous system (CNS) depressant drugs.

Insomnia, headache, excitation, tremor, tachycardia, arrhythmia, palpitation, difficult urination, and gastrointestinal disturbance.

Chlorpheniramine maleate may cause drowsiness, and dry mouth.

See boxed warning.

Concomitant use with monoamine oxidase inhibitor (MAOI) antidepressant may cause hypertensive crisis.

The effect of treatment which acts centrally (sympathomimetics, antidepressants) may be increased by pseudoephedrine hydrochloride or chlorpheniramine.



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Prism - Definition Of Prism By The Free Dictionary, Prisma

prism

prism

1. A solid figure whose bases or ends have the same size and shape and are parallel to one another, and each of whose sides is a parallelogram.

2. A transparent body of this form, often of glass and usually with triangular ends, used for separating white light passed through it into a spectrum or for reflecting beams of light.

3. A cut-glass object, such as a pendant of a chandelier.

4. A crystal form consisting of three or more similar faces parallel to a single axis.

5. A medium that misrepresents whatever is seen through it.

[Late Latin prīsma . from Greek prīsma . thing sawed off, prism . from prīzein . to saw . variant of prīein .]

prism

1. (General Physics) a transparent polygonal solid, often having triangular ends and rectangular sides, for dispersing light into a spectrum or for reflecting and deviating light. They are used in spectroscopes, binoculars, periscopes, etc

2. (General Physics) a form of crystal with faces parallel to the vertical axis

3. (Mathematics) maths a polyhedron having parallel, polygonal, and congruent bases and sides that are parallelograms

[C16: from Medieval Latin prisma, from Greek: something shaped by sawing, from prizein to saw]

prism

1. Optics. a transparent solid body, often having triangular bases, used for dispersing light into a spectrum or for reflecting rays of light.

2. Geom. a solid having bases or ends that are parallel, congruent polygons and sides that are parallelograms.

3. Crystall. a form having faces parallel to the vertical axis and intersecting the horizontal axes.

[1560–70; < Late Latin prīsma < Greek prisma literally, something sawed, akin to prizein to saw, pristēs sawyer]

prism

1. A geometric solid whose bases are congruent polygons lying in parallel planes and whose sides are parallelograms.

2. A solid of this type, often made of glass with triangular ends, used to disperse light and break it up into a spectrum.

prism

A transparent, solid object, with at least two plane faces, that bends a light beam and splits it into its component colors.

Thesaurus Antonyms Related Words Synonyms Legend:

prism

prism

1. a solid figure whose sides are parallel and whose two ends are the same in shape and size. prisma ??????? призма prisma hranol das Prisma prisme ?????? prisma prisma ????? sarmio prisme ???????? ????????? hasab prisma (marg)strendingur prisma ?? ??? prizme prizma prisma prisma prisme graniastoslup ????? prisma prisma призма hranol prizma prizma prisma ???????????? prizma ?? призма ?????? ???? ??? ?? ?? ????? ??? ????? ??? ????? ??? lang tr? ??

2. a glass object of this shape, usually with triangular ends, which breaks up a beam of white light into the colours of the rainbow. prisma ?????? призма prisma prizma das Prisma prisme ?????? prisma prisma ????? ??? ??? prisma prisme ?????????? ????????? prizma prisma prisma, strendingur prisma ???? ??? prizme prizma prisma prisma prisme pryzmat ????? ????? prisma prisma призма prizma prizma prizma prisma ?????????????? prizma ?? призма ?????? ??? ??? ???? ?? ?? ??? lang kinh ??

pris?matic ( - ?ma - ) adjective

prismaties ????????? ???????? призматичен prismatico hranolovy Prismen-. stralende ??????????? prismatico prisma - ????? ????? prismaattinen prismatique ????????? ????????????, ???????????? prizma alaku berbentuk prisma strendur prismatico ????? ????, ??? prizminis prizmas-; prizmatisks berbentuk prisma prismatisch prismatisk. stralende pryzmatyczny ? ????? ?? ??? prismatico prismatic призматический hranolovy prizmaticen prizmatican prismatisk ??????????? prizma seklinde ???? призматичний ????? ?? ????? thu?c lang tr? ????

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References in classic literature ?

The mammoth grand-stand was clothed in flags, streamers, and rich tapestries, and packed with several acres of small-fry tributary kings, their suites, and the British aristocracy; with our own royal gang in the chief place, and each and every individual a flashing prism of gaudy silks and velvets -- well, I never saw anything to begin with it but a fight between an Upper Mississippi sunset and the aurora borealis.

In a young man of twenty-three the senses count for much in love; their fire produces a sort of prism between his eyes and the woman.

He wore but a single article of clothing or adornment, a small collar of gold from which depended upon his chest a great ornament as large as a dinner plate set solid with huge diamonds, except for the exact center which was occupied by a strange stone, an inch in diameter, that scintillated nine different and distinct rays; the seven colors of our earthly prism and two beautiful rays which, to me, were new and nameless.

His name and his bright past, seen through the prism of whispered gossip, had gained him the nickname of THE ADMIRAL.

It was then ten in the morning; the rays of the sun struck the surface of the waves at rather an oblique angle, and at the touch of their light, decomposed by refraction as through a prism. flowers, rocks, plants, shells, and polypi were shaded at the edges by the seven solar colours.

In the atmosphere of the Easterly weather, as pellucid as a piece of crystal and refracting like a prism. we could see the appalling numbers of our helpless company, even to those who in more normal conditions would have remained invisible, sails down under the horizon.

It scintillated nine different and distinct rays; the seven primary colours of our earthly prism and the two rays which are unknown upon Earth, but whose wondrous beauty is indescribable.

Of course I submitted to him, because it was my duty; it was my feeling for him," said Dorothea, looking through the prism of her tears.

His face and eyes were as beautiful as ever, and his fancy was still like a prism. separating everything that fell upon it into rainbows.

Every light, if you can split it up with a prism. gives the same colours.

At the other end of the series we have the cells of the hive-bee, placed in a double layer: each cell, as is well known, is an hexagonal prism. with the basal edges of its six sides bevelled so as to join on to a pyramid, formed of three rhombs.

Proceeding from a religious heart it will raise to a divine use the railroad, the insurance office, the joint - stock company; our law, our primary assemblies, our commerce, the galvanic battery, the electric jar, the prism. and the chemist's retort; in which we seek now only an economical use.



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Cyproterone Acetate, Cyproteron

Cyproterone Acetate

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.



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Remethan, Remethan

Remethan ® [Diclofenac]

Presentations

Enteric-coated tablets 25 and 50mg. Slow-release tablets 100mg. Topical gel 1% 20,50 and 100mg. Suppositories 100mg.

Properties:

Diclofenac sodium, the active ingredient of Remethan ® is a non-steroidal anti-inflammatory agent (NSAID), a phenylacetic acid derivative, which has marked analgesic, antipyretic and anti-inflammatory properties. It is an inhibitor of prostaglandin synthetase.

Indications

Remethan ® is indicated for the treatment of rheumatoid arthritis, ankylosing spondylitis, oseteoarthrosis, low back pain, frozen shoulder, tendinitis, tenosynovitis, bursitis, strains, sprains and acute gout. Remethan ® is also indicated for the control of pain and inflammation in orthopaedic, dental and other minor surgery. Remethan ® 25: In children is indicated for the treatment of Juveline chronic arthritis. Remethan ® 100R: is not indicated for children. Remethan ® gel: is indicated for the local symptomatic relief of pain and inflammation in: trauma of the tendons, ligaments, muscles and joints, e. g. due to sprains, strains and bruises, localised forms of soft tissue rheumatism and for the treatment of osteoarthritis of superficial joints such as the knee.

Dosage

Remethan ® 25 and 50mg

Adults: the recommended adult dose is 75-150mg daily given in two or three divided doses. The maximum daily dose is 150mg. Children: Children should be given 1-3mg/kg per day in divided doses (only for remethan ® 25).

Remethan ® 100R

Adults: the recommended adult dose is one tablet daily, taken whole with liquid, preferably at meal times. If necessary, the daily dosage can be increased to 150 mg by supplementation with conventional remethan ® Tablets.

Remethan ® Gel

Adults: Remethan ® Gel should be rubbed gently into the skin. Depending on the size of the affected side to be treated 2-4g(a circular shaped mass approximately 2. 0-2.5cm in diameter) should be applied 3-4 times daily. Remethan ® Gel is not recommended for use in children.

Remethan ® Suppositories

Adults: the recommended dose is one 100mg suppository daily, usually administrated at night. In more severe cases, combined therapy with 25 or 50mg tablets is recommended. The total daily dose should not exceed 150mg.

Side-effects

There have been reported: gastrointestinal disturbances, hypersensitivity reactions, haematological effects, liver or renal dysfunction, cardiovascular and cerebrovascular effects. For more information please see the summary of product characteristics.



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Mena Financial Expo Dubai 2016, Meforex

Xtrade is a renowned digital trading platform for retail clients. Established in 2009, the Cyprus-based brokerage operates 21 regional offices and enables traders to trade CFDs on Forex, stocks, shares, indices, and commodities. Xtrade’s main services include five cutting-edge digital platforms, trading analysis tools, and a menu of 1,000 tradable assets. Xtrade’s mobile trading apps offer the latest in financial technology, for example single-swipe trading, real-time alerts, and live order fill notifications.

Xtrade puts a premium on trading security. The company is regulated by the European Union’s Cyprus and Exchange Commission, the EU’s Markets in Financial Instruments Directive, and the Australian Securities and Investments Commission.

Xtrade’s Global Ambassador is football star Cristiano Ronaldo.

For more information, visit www. xtrade. com

AvaTrade is a pioneer of online Forex and CFD trading, and a leading broker within this arena. The company’s main focus is to empowering people to trade with confidence in an innovative and reliable environment with 24-hour, 5 days a week multilingual help desks in 14 language. AvaTrade is regulated across Europe, Australia, Japan, South Africa and the British Virgin Islands.

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FxPro is an award-winning online broker, offering CFDs on forex, futures, indices, shares, spot metals and energies, serving clients in more than 150 countries worldwide. FxPro offers execution with no-dealing - desk intervention and maintains a client-centric business model that puts customer needs at the forefront of our operations. Our acquisition of leading spot FX aggregator, Quotix, enables us to offer access to a deep pool of liquidity, as well as top-class order-matching and some of the most competitive spreads in the market. FxPro is one of only few brokers offering Negative Balance Protection, ensuring that clients cannot lose more than their overall investment. FxPro UK Limited is authorised and regulated by the Financial Conduct Authority (registration number: 509956). FxPro Financial Services Limited is authorised and regulated by the Cyprus Securities and Exchange Commission (licence number: 078/07) and by the South Africa Financial Services Board (authorisation number 45052). Risk Warning: Trading CFDs involves significant risk of loss. Risk Disclosure: www. fxpro. co. uk/documents/risk-disclosure Specialties Contracts for Difference (CFDs) on forex, futures, indices, shares, spot metals and energies.

Websitewww. fxpro. co. uk Industry: Financial Services Type: Privately Held Headquarters: 13-14 Basinghall street London, City of London EC2V 5BQ United Kingdom Company Size 51-200 employees Founded: 2006

FXPRIMUS is globally acclaimed for offering one of the most secure online trading environments available anywhere in the forex industry. Client funds are protected via an award-winning risk management model, built to withstand any unexpected market volatility. We are fully regulated by CySEC, and in full compliance with the regulations of Markets in Financial Instruments Directive (MiFID.) We also have an official partnership with Manchester City FC.

Clients of FXPRIMUS are welcomed with a $33 no deposit bonus to KickStart their trading journey to success.

HotForex is an award-winning forex and commodities broker, offering trading services and facilities to both retail and institutional clients. Through its policy of providing the best possible trading conditions to its clients and allowing both scalpers and traders using expert advisors unrestricted access to its liquidity, HotForex has positioned itself as the forex broker of choice for traders worldwide. Its vision is to maintain its market leader status known for superior customer services.

Swissquote Bank Ltd is the leading provider of online financial services in Switzerland. It is a recognized public bank supervised by the Swiss Financial Market Supervisory Authority, which means that creditors and investors of the company are protected by the Swiss banking security standards.

Swissquote also ranks among the top 10 online Forex brokers in the world, empowering over 200,000 private investors and institutional clients to trade a wide range of currencies, commodities and indices. Always at the forefront of technological innovation, it develops cutting-edge solutions and analysis tools to meet the needs of its clients, whether they are beginners or experts.

In addition to Advanced Trader, Swissquote’s proprietary platform, the popular MetaTrader 4 and 5 platforms are also fully integrated into its superior liquidity combined with low trading costs and precise execution.

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Swissquote Group has offices in multiple locations in Switzerland, as well as in Dubai, London, Malta and Hong Kong, to serve customers in over 120 countries. Swissquote Group Holding Ltd (SQN) is listed on the SIX Swiss Exchange.

Swissquote is proud to be the official bank of the 15th MENA Forex Show and will be pleased to share its expertise with all visitors.

TradeSocio provides cloud-based marketing technology to companies in the financial services sector. TradeSocio’s solutions include a white-label social trading platform, big data, and a marketing platform that enables financial institutions to improve their marketing and sales effectiveness.

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Tradesto is founded by a group of institutional traders and technology evangelist with a combined trading, investment, technology and financial experience of 60 years. Its shareholders and directors have combined net worth of 500 million USD and above.

As an independent brokerage, Tradesto has gained the trust of institutional and private customers. With the best technology, we ensure safe, secure, speedy and simple trading experience. Tradestohas its headquarters in New Zealand, offices in Saint Vincent and UK.

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Excellent Service

Prime by ADS Securities is an exclusive service that changes the way private clients trade forex, bullion and CFDs. Prime extends institutional standards of execution with tailored support for individual investors across FX, precious metals and CFDs. Access ADS Securities’ deep liquidity, market-leading prices and spreads for an exceptional trading experience. Prime: award-winning technology and personalized customer service.

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AFX Capital offers trading and investment services in multiple languages throughout the world. Catering to both retail and institutional clients, we provide access to a wide range of diversified products and services of exceptional standards, falling under four trading brands:

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AFX Affiliates, delivering turnkey, highly-innovative partnership and technological solutions.

16th MENA FFXPO, Managed Funds & Investment Show 2016

MENA 15th Forex, Managed Funds & Investment Show 2015

MENA 14th Forex Show, Managed Funds & Investment Show 2015

MENA 13th Forex Show, Managed Funds & Investment Opportunities 2014

MENA 12th Forex Show, Managed Funds & Investment Opportunities 2013

MENA 11th Forex Show, Managed Funds & Investment Opportunities 2013

MENA 10th Forex Show, Managed Funds & Investment Opportunities 2012

The 9th MENA Forex & Investment Summit 2011

The 8th MENA Forex Expo & Conference 2011

The 7th MENA Forex and The Middle East Online Trading Summit & Awards 2010

The 6th MENA Forex Expo 2010

The 5th MENA Forex Trading Expo 2009

The 4th MENA Forex & Middle East Money Summit 2008

3rd MENA Forex Trading Expo Bahrain 2008

The 2nd MENA Forex Trading Expo 2007

The 1st MENA Forex Trading Expo 2007

President Message

Following the great success and response of our April show, where we welcomed 1300 visitors we have launched our November 2016 show.

Be the First to book your package at our upcoming 17th MENA FFXPO to be held on 3-4 November 2016 in The Westin Mina Seyahi Hotel Dubai A 2 days event targeting The B2B and B2C Investors, Traders, Institutions, Corporates, Banks, Family Offices in the MENA Region

Get from today Prominent branding, Prime Location at the Expo, online presence on our event website, from now till the Expo, and get in advance the data base of the visitors who will register online on a daily basis so you can network with them, sell them, establish business relations, months before the show.

If you are involved as a Broker or company providing services into one of the following fields than this is the show to be in : Forex – Stocks - Shares – Options - CFDs – Indices – Bonds - Investments – Managed Portfolios – Managed FX funds – Wealth management – Binary Options - Future options - Payment systems – Liquidity provider - Analytics - Automated Trading – Social Trading – Robots – Platforms – Signals provider – News and Technical analysis provider – Education and Training provider – Translating Services - and more……

Take care and refrain from saying you have time to our Next show because it is 6 months ahead, in fact taking off Weekends, summer Vacations, and National Holidays it is only 100 working days away

Our team will serve you and provide you all needed information contact vp@arabcomgroup. com & sales@arabcomgroup. com

Katia Tayar Founder & President Arabcom Group

Arabcom Group has launched the first series of Forex, Online Trading, Managed Funds and Investments shows in the MENA region in 2007.

Since 1993, Arabcom Group is a pioneer in promoting sustainable socio-economic development in the Middle East. It has in its portfolio over 100 specialized conferences and exhibitions in Telecom, ICT, financial, real estate and other sectors.

vp@arabcomgroup. com ? +971.4.3903511 ? +961.5.450212 or +961.3.214215 ? P. O Box 502040 Dubai © 17th MENA FFXPO International Financial Forum & Expo 2016 All Rights Reserved to Arabcom Group Developed by Adagio Infotech Pvt. Ltd.



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Heptovir Advanced Patient Information, Heptovir

Heptovir (Oral)

Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported. Severe acute exacerbations of hepatitis B have been reported in patients who have discontinued anti-hepatitis B therapy (including EPIVIR-HBV(R)) or who are co-infected with hepatitis B virus (HBV) and HIV-1 and have discontinued EPIVIR(R); monitor hepatic function upon discontinuation of therapy. EPIVIR(R) Tablets and Oral Solution (used to treat HIV-1 infection) contain a higher dose of the active ingredient (lamivudine) than EPIVIR-HBV(R) Tablets and Oral Solution (used to treat chronic hepatitis B infection). Patients with HIV-1 infection should receive only dosage forms appropriate for treatment of HIV-1. EPIVIR-HBV(R) is not approved for the treatment of HIV-1 infection. HIV-1 resistance may emerge in chronic hepatitis B-infected patients with unrecognized or untreated HIV-1 infection; offer HIV counseling and testing to all patients prior to beginning treatment with EPIVIR-HBV(R) and periodically during therapy .

Commonly used brand name(s)

Available Dosage Forms:

Therapeutic Class: Antiretroviral Agent

Pharmacologic Class: Nucleoside Reverse Transcriptase Inhibitor

Uses For Heptovir

Lamivudine is used in combination with other medicines for the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS).

Lamivudine will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of serious health problems usually related to AIDS or HIV disease from occurring. Lamivudine will not keep you from spreading HIV to other people. People who receive this medicine may continue to have other problems usually related to AIDS or HIV disease.

Lamivudine is also used to treat chronic (long-term) hepatitis B virus (HBV) infection.

This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, lamivudine is used in certain patients with the following medical condition:

Human immunodeficiency virus (HIV) infection due to occupational exposure (possible prevention of)

Before Using Heptovir

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of lamivudine for the treatment of HIV infection in children 3 months to 16 years of age. However, safety and efficacy have not been established in children younger than 3 months of age.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of lamivudine for the treatment of chronic hepatitis B infection in children 2 to 17 years of age. However, safety and efficacy have not been established in children younger than 2 years of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lamivudine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving lamivudine.

Pregnancy

Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Dasabuvir

Interferon Alfa

Paritaprevir

Ribavirin

Zalcitabine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Diabetes—The oral solution contains sucrose, which can make this condition worse.

Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Liver disease—Use with caution. May make this condition worse.

Pancreatitis (inflammation or swelling of the pancreas), history of—Epivir® should be used with caution. May make this condition worse.

Proper Use of lamivudine

This section provides information on the proper use of a number of products that contain lamivudine. It may not be specific to Heptovir. Please read with care.

Take this medicine exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Epivir® and Epivir-HBV® both contain the same medicine, but Epivir® has more medicine in each tablet or dose of liquid. Use only the brand of this medicine that your doctor prescribed . If you have HIV or AIDS, you need to use Epivir® . If you have hepatitis B but you do not have HIV or AIDS, you can use Epivir-HBV® .

Your doctor may want to test you for HIV before you start using Epivir-HBV® and during your treatment. Your medicine may need to be changed based on these test results.

It is important to take Epivir® as part of a combination regimen. Take all of the medicines your doctor prescribed at the right time of day. This will make your medicines work better.

Keep taking lamivudine for the full time of treatment . even if you or your child begin to feel better. Do not stop taking it without checking first with your doctor. When your supply of the medicine is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of the medicine.

If you are using the oral liquid . use a specially marked measuring spoon, dosing syringe, or medicine cup to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (solution or tablets):

For treatment of hepatitis B infection:

Adults—100 milligrams (mg) once a day.

Children 2 to 17 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 3 milligrams (mg) per kilogram (kg) of body weight per day. The doctor may increase your dose as needed. However, the dose is usually not more than 100 mg per day. If your child cannot swallow the tablets, he or she may take the oral liquid.

Children younger than 2 years of age—Use and dose must be determined by your doctor.

For treatment of HIV infection or AIDS:

Adults and children 17 years of age and older—300 milligrams (mg) once a day or 150 mg two times a day.

Children 3 months to 16 years of age—

Solution: Dose is based on body weight and must be determined by your doctor. The dose is usually 4 milligrams (mg) per kilogram (kg) of body weight taken two times a day, or 8 mg per kg once a day. The doctor may increase your dose as needed. However, the dose is usually not more than 150 mg two times a day, taken with other HIV medicines.

Tablets: Dose is based on body weight and must be determined by your doctor. The dose is usually 150 to 300 mg per day.

Children younger than 3 months of age—Use and dose must be determined by your doctor.

Note: Patients that require treatment for both hepatitis B and either AIDS or HIV should follow the dosing schedule for HIV or AIDS.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Heptovir

It is very important that your doctor check the progress of you or your child at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Do not use this medicine if you or your child is also taking zalcitabine or medicines containing emtricitabine or lamivudine (eg, Atripla®, Combivir®, Complera®, Emtriva®, Epzicom®, Stribild®, Trizivir®, Truvada®). Tell your doctor right away if you are using any of these medicines.

Two rare but serious reactions to this medicine are lactic acidosis (build-up of acid in the blood) and liver toxicity, including an enlarged liver. These are more common if you are female, very overweight (obese), or have been taking anti-HIV medicines for a long time. Call your doctor right away if you or your child has stomach discomfort or cramping, nausea, vomiting, or diarrhea, a decreased appetite, a general feeling of discomfort, muscle cramping or pain, unusual tiredness or weakness, trouble breathing, or yellow skin or eyes.

This medicine may cause worsening of hepatitis B infection when treatment is stopped.

Pancreatitis may occur while you are using Epivir®. Tell your doctor right away if you or your child has sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

Your immune system may get stronger when you start taking Epivir®. This could cause a hidden infection in your body to become active. Tell your doctor right away if you or your child notice any changes in your health.

Epivir® may cause you or your child to have excess body fat. Tell your doctor right away if you notice changes in your body shape, including an increased amount of body fat in the neck or upper back, face, around the chest, or stomach area. You might also lose fat from your legs, arms, or face.

Lamivudine does not decrease the risk of transmitting HIV infection to others through sexual contact or by contamination through blood. HIV may be acquired from or spread to others through infected body fluids, including blood, vaginal fluid, or semen. If you are infected, it is best to avoid any sexual activity involving an exchange of body fluids with other people. If you do have sex, always wear (or have your partner wear) a condom (“rubber”). Only use condoms made of latex or polyurethane and use them every time you have contact with semen, vaginal secretions, or blood. Also, do not re-use or share needles or equipment with anyone. If you have any questions about this, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Heptovir Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach discomfort

black, tarry stools

bleeding gums

bloating

blood in the urine or stools

chills

constipation

cough

darkened urine

decreased appetite

diarrhea

difficulty with swallowing

dizziness

fast heartbeat

fast, shallow breathing

fever

general feeling of discomfort

general tiredness and weakness

indigestion

light-colored stools

loss of appetite

muscle cramps or spasms

muscle pain or stiffness

nausea and vomiting

pains in the stomach, side, or abdomen, possibly radiating to the back

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

right upper abdominal or stomach pain and fullness

skin rash, hives, or itching

sleepiness

tightness in the chest

unusual bleeding or bruising

unusual tiredness or weakness

upper right abdominal or stomach pain

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

belching

burning, tingling, numbness or pain in the hands, arms, feet, or legs

depression

general feeling of discomfort or illness

headache

heartburn

indigestion

muscle or joint pain

sensation of pins and needles

sore throat

stabbing pain

stomach discomfort, upset, or pain

stuffy or runny nose

trouble sleeping

weight loss

Incidence not known

Blurred vision

dry mouth

flushed, dry skin

fruit-like breath odor

hair loss or thinning of the hair

increased hunger

increased thirst

increased urination

pale skin

sweating

troubled breathing with exertion

unexplained weight loss

weight gain around your neck, upper back, breast, face, or waist

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Truven Health Micromedex products as delivered by Drugs. com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products.

Copyright 2016 Truven Health Analytics, Inc. All Rights Reserved.



Buy Online Heptovir Advanced Patient Information, Heptovir

Laxamag, 10 Mg, Supozitoare - Prospect Laxamag, 10 Mg, Supozitoare, Laxamag

Laxamag, 10 mg, supozitoare

Ce este Laxamag si pentru ce se utilizeaza

Laxamag este un laxativ cu actiune locala, care produce stimularea miscarilor peristaltice ale intestinului si diminuarea consistentei fecalelor.

Laxamag apartine unui grup de medicamente numite laxative. Laxamag este utilizat pentru tratamentul de scurta durata al constipatiei, pentru pregatirea investigatiilor medicale, inainte si dupa operatii si afectiuni care necesita facilitarea evacuarii colonului.

Se administreaza la adulti si copii cu varsta peste 10 ani.

Inainte sa utilizati Laxamag

Nu utilizati Laxamag

daca sunteti alergic (hipersensibil) la bisacodil sau la oricare dintre celelalte componente ale Laxamag;

daca suferiti de ileus (oprire temporara a miscarilor peristaltice ale intestinului) sau obstructie intestinala;

daca suferiti de abdomen acut chirurgical, incluzand apendicita, boli inflamatorii intestinale acute;

daca corpul dumneavoastra a pierdut multe lichide;

daca aveti dureri abdominale severe asociate cu greata si varsaturi, care pot fi semne ale unei afectiuni severe;

aveti fisuri anale;

aveti proctita si rectoragii;

la copii cu varsta sub 10 ani.

Aveti grija deosebita cand utilizati Laxamag

Laxamag trebuie utilizat numai in tratamentul de scurta durata al constipatiei.

Daca dumneavoastra va este necesara administrarea zilnica de laxative sau pe perioade indelungate, atunci trebuie sa-i spuneti medicului dumneavoastra pentru a investiga cauza constipatiei, deoarece administrarea excesiva perioade indelungate poate produce un dezechilibru hidroelectrolitic si valori scazute ale potasiului din sange (hipokaliemie).

Au fost raportate ameteli si/sau sincope la pacienti tratati cu Laxamag. Aceste evenimente pot fi corelate cu constipatia si nu neaparat administrarii de Laxamag.

Daca utilizati timp indelungat Laxamag puteti avea:

o anumita afectiune numita boala laxativelor precum si anumite dezechilibre cum sunt pierderi de apa si electroliti, inclusiv de potasiu si/sau vitamine;

dependenta (cu necesitatea administrarii repetate a laxativului, a cresterii dozelor si constipatie severa in cazul intreruperii tratamentului).

In caz de torsada varfurilor se recomanda administrarea unui laxativ non-stimulant (hipokaliemia este un factor favorizant, ca si bradicardia si sindromul de QT prelungit preexistent).

Nu trebuie administrat Laxamag la copii cu varsta sub 10 ani fara recomandarea medicului.

Utilizarea altor medicamente

Va rugam sa spuneti medicului dumneavoastra sau farmacistului daca luati sau ati luat recent orice alte medicamente, inclusiv dintre cele eliberate fara prescriptie medicala si medicamentele pe baza de plante.

Evitati administrarea concomitenta a Laxamag cu medicamente care pot determina torsada varfurilor:

antiaritmice (amiodarona, bretiliu, disopiramida, sotalol, chinidinice);

astemizol, bepridil, eritromicina i. v. halofantrina, pentamidina, sultopirida, terfenadina, vincamina), deoarece poate sa apara hipokaliemie in cazul unei utilizari prelungite sau in doze mari.

Utilizati cu prudenta Laxamag cu:

glicozide tonicardiace;

diuretice hipokaliemiante;

amfotericina B i. v.;

glucocorticoizi si mineralocorticoizi administrati sistemic);

tetracosactid.

Deoarece bisacodilul poate sa scada absorbtia altor medicamente, se recomanda utilizarea cu prudenta in cazul asocierii, de exemplu cu anticonceptionale orale.

Sarcina si alaptarea

Adresati-va medicului dumneavoastra sau farmacistului pentru recomandari inainte de a lua orice medicament.

Adresati-va medicului dumneavoastra pentru recomandari inainte de a lua Laxamag in cazul in care sunteti insarcinata, planuiti sa ramaneti insarcinata sau alaptati.

Conducerea vehiculelor si folosirea utilajelor

Nu s-au efectuat studii privind efectele Laxamag asupra capacitatii de a conduce vehicule si de a folosi utilaje.

Cum sa utilizati Laxamag

Utilizati intotdeauna Laxamag exact asa cum scrie in acest prospect sau asa cum v-a spus medicul dumneavoastra. Trebuie sa discutati cu medicul dumneavoastra sau cu farmacistul daca nu sunteti sigur.

Este destinat pentru administrare rectala.

Daca nu este prescris altfel de catre medic, sunt recomandate urmatoarele doze:

Adulti si copii cu varsta peste 10 ani: doza uzuala este de un supozitor Laxamag 10 mg pe zi, administrat timp de 5 zile.

Pentru pregatirea procedurilor diagnostice si preoperator

Pentru administrarea bisacodilului in vederea pregatirii pacientului pentru proceduri diagnostice, in tratamentul pre-sau postperator si in afectiuni care necesita facilitarea evacuarii colonului, Laxamag trebuie administrat sub supraveghere medicala.

Pentru evacuarea completa a colonului, doza recomandata de Laxamag recomandata este de un supozitor Laxamag 10 mg, cu 30-60 minute inainte de momentul stabilit pentru evacuarea colonului.

Utilizarea la copii cu varsta sub 10 ani

Nu se recomanda administrarea Laxamag 10 mg supozitoare la copii cu varsta sub 10 ani.

Nu exista recomadari speciale pentru aceasta categorie de varsta. Instructiuni de utilizare a supozitoarelor:

Desprindeti cele doua parti ale ambalajului si impingeti pentru a iesi supozitorul.

Pentru administrare se recomanda sa va culcati pe o parte si sa introduceti supozitorul intrarectal profund.

Se recomanda, de asemenea, sa ramaneti culcat timp de 15 pana la 20 minute, timp necesar pentru aparitia efectului laxativ.

Daca uitati sa utilizati Laxamag

Daca ati uitat sa luati o doza, luati-o cat de repede va amintiti, dar nu luati o doza dubla pentru a compensa doza uitata.

Daca utilizati mai mult decat trebuie din Laxamag

Daca luati doze mari, se pot produce scaune lichide (diaree), crampe abdominale si pierderi de potasiu si de alti electroliti.

In caz de supradozaj, adresati-va imediat medicului dumneavoastra sau mergeti la cel mai apropiat spital.

Daca incetati sa luati Laxamag

Laxamag trebuie luat numai la nevoie si trebuie intrerupt dupa ameliorare.

Daca aveti orice intrebari suplimentare cu privire la acest produs, adresati-va medicului dumneavoastra sau farmacistului.

Reactii adverse posibile

Ca toate medicamentele, Laxamag poate provoca reactii adverse, cu toate ca nu apar la toate persoanele.

Reactiile adverse sunt clasificate dupa urmatoarele frecvente:

Mai putin frecvente: varsaturi, disconfort abdominal.

Frecvente: dureri abdominale, crampe abdominale, greata, diaree (cu hipokaliemie). Rare: reactii de hipersensibilitate.

Cu frecventa necunoscuta: colita, reactii anafilactice, angioedem, deshidratare, atonie intestinala. Administrarea repetata poate determina proctita.

Daca vreuna dintre reactiile adverse devine grava sau daca observati orice reactie adversa nementionata in acest prospect, va rugam sa spuneti medicului dumneavoastra sau farmacistului.

Cum se pastreaza Laxamag

A nu se lasa la indemana si vederea copiilor. A se pastra la temperaturi sub 25°C, in ambalajul original.

Nu utilizati Laxamag dupa data de expirare inscrisa pe ambalaj, dupa EXP. Data de expirare se refera la ultima zi a lunii respective.

Medicamentele nu trebuie aruncate pe calea apei menajere sau a reziduurilor menajere. Intrebati farmacistul cum sa eliminati medicamentele care nu va mai sunt necesare. Aceste masuri vor ajuta la protejarea mediului.

Informatii suplimentare

Ce contine Laxamag

Substanta activa este bisacodil . Un supozitor contine bisacodil 10 mg.

Celelalte componente sunt: gliceride solide de semisinteza.

Cum arata Laxamag si continutul ambalajului

Laxamag se prezinta sub forma de supozitoare in forma de torpila de culoare alba sau alb-galbuie. Este ambalat in cutii cu 2 blistere a cate 3 supozitoare.

Detinatorul autorizatiei de punere pe piata si producatorul

Detinatorul autorizatiei de punere pe piata si fabricantul

Magistra C&C SRL B-dul Aurel Vlaicu nr.82 A 900055, Constanta Romania

Acest prospect a fost aprobat in Decembrie 2010



Buy Online Laxamag, 10 Mg, Supozitoare - Prospect Laxamag, 10 Mg, Supozitoare, Laxamag