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Naproxen sodium is the generic ingredient in Aleve and several other brands of pain medication.

Naproxen is in a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs), which work by blocking the production of prostaglandins, substances in the body that play a role in pain and inflammation.

Naproxen has been used in the United States since 1980. It is available generically and under many brand names.

After 14 years as a prescription-only medication, in 1994 naproxen was approved by the Food & Drug Administration (FDA) as an over-the-counter (OTC) drug.

The best-known brand name for OTC naproxen is Aleve, which is made by the Bayer Healthcare.

Other brand names for naproxen include Anaprox DS, Naprelan, Anaprox, EC-Naprosyn, and Naprosyn.

As a prescription-strength drug, naproxen comes in the form of tablets or as a liquid.

Tablets may be coated to protect your stomach, or they may be extended-release tablets that you need to take only once a day.

Prescription-strength naproxen is often used to treat joint pain, menstrual pain, rheumatoid arthritis. gout, ankylosing spondylitis. juvenile arthritis, tendonitis, and bursitis.

Nonprescription naproxen is commonly used to relieve pain, swelling, fever, cold and flu symptoms, and headaches.

Naproxen Warnings

Naproxen may raise your risk for heart attacks and stroke .

Heart and stroke risk is greater if you have a history of or risk factors for heart disease.

Naproxen may cause ulcers and bleeding in your gastrointestinal (GI) tract. Ulcer and bleeding risk is higher if you are elderly.

Because elderly people are more likely to have side effects, you should take the lowest possible effective dose if you are over age 65.

This drug is not recommended for children younger than 2 years.

Always tell your doctor if you are taking naproxen before having any surgical procedure, including dental surgery.

Before you take naproxen, it is important to tell your doctor or pharmacist about any allergies to NSAIDs.

In addition to stroke, heart disease, and gastrointestinal bleeding, other conditions also carry warnings related to naproxen use, so tell your doctor or pharmacist if you have any of these conditions:

High blood pressure

Fluid retention

Kidney disease

Liver disease

Anemia

Asthma

Nasal congestion or nasal polyps

Stomach ulcer

Inflammatory bowel disease (IBD)

Naproxen and Pregnancy

Naproxen may cause harm to a developing fetus, and should not be used in the later stages of pregnancy.

There's some evidence that naproxen can cause problems for developing babies and increase the risk for maternal bleeding during delivery.

Naproxen and Breastfeeding

Studies of naproxen use by women who are breastfeeding are inconsistent.

Some evidence suggests that naproxen is safe for a breastfeeding mother to use in moderate doses if her infant is at least one month old.

However, the American Academy of Family Physicians warns that naproxen can accumulate in an infant if a breastfeeding mother uses the drug for an extended period of time.

Ask your doctor if it's safe to use naproxen while breastfeeding. There may be safer alternatives for you and your nursing baby.

Q: When my husband had outpatient surgery on his back (lumbar discectomy), we were told that he should not take naproxen (500 mg) because it hinders the healing process. Yet my foot doctor gave me a prescription for naproxen (500 mg) to ease the swelling I experienced after foot surgery. So we are confused. Does Naproxen hinder the healing process? In both of our surgeries, we had bones that needed to heal.

A: Non-steroidal anti-inflammatory drugs like naproxen are powerful and effective drugs. They are routinely used in orthopedic conditions and in the perioperative setting. They are however associated with potentially serious side effects, and it is important to evaluate the risk versus benefit prior to medication use. There is evidence suggesting that these drugs adversely affect bone formation, and this has implications for their use in patients with fractures and other pathologies that involve bone remodelling. Similarly, other data suggest that nonsteroidal anti-inflammatory drugs significantly inhibit spinal fusion at doses typically used for postoperative pain control.

Q: Can Naproxen 500 mg or high blood pressure medications cause weight gain?

A: Naproxen does not appear to cause weight gain in patients taking the medication. High blood pressure medications do not generally cause weight gain, but if you are experiencing a sudden weight change you should consult your physician to rule out fluid retention.

Q: Can Naproxen 500 mg or high blood pressure medications cause weight gain?

A: Naproxen does not appear to cause weight gain in patients taking the medication. High blood pressure medications do not generally cause weight gain, but if you are experiencing a sudden weight change you should consult your physician to rule out fluid retention.

Q: I've been taking naproxen 500 mg twice a day for a year now for arthritis and bursitis pain. What are the long-term effects? Is it safe to continue?

A: According to the medication guide for naproxen, you should not stop taking this medication with out first consulting your health care provider. Naproxen is in a group of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). NSAID medicines may increase the chance of a heart attack or stroke that can lead to death. This chance increases with longer use of NSAID medicines in people who have heart disease. NSAID medicines can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can happen without warning symptoms and may cause death. NSAID medicines should only be used exactly as prescribed at the lowest dose possible for your treatment for the shortest time needed. Do not take an NSAID medicine if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine for pain right before or after heart bypass surgery. Tell your health care provider about all of your medical conditions and all of the medicines you take. NSAIDs and some other medicines can interact with each other and cause serious side effects. These are not all the side effects with NSAID medicines. Talk to your health care provider for more information about NSAID medicines.

Q: What is the effect of naproxen sodium on the kidneys?

A: Depending on the individual, naproxen can have a effect on kidneys. As long as you have good kidney function and no liver disease, you can use naproxen. Your health care provider should monitor your kidney functions as long as you are on this medication. The following are kidney conditions are listed in the literature: glomerular nephritis, hematuria, interstitial nephritis, nephrotic syndrome, nephropathy and tubular necrosis. Be sure to discuss your concerns with your health care provider. I have included a site with more information for you. http://www. everydayhealth. com/drugs/naproxen Gerald R. Levy, RPh

Q: I'm a type 2 diabetic and have started spilling phosphorus into my urine, A1C 6.4. Could naproxen be the culprit?

A: According to the FDA, the use of drugs like naproxen (Brand: Aleve), which are called NSAIDs, have been reported to cause kidney damage especially with long-term use and at high doses. Patients with impaired kidney function (which diabetes can cause over time) should avoid NSAIDs all together if possible. If while taking an NSAID, you develop sudden weight gain or fluid retention (for example, you notice swelling in your legs), notify your doctor right away. NSAIDs such as naproxen can also cause a change in blood sugar and decrease the effectiveness of oral diabetes medications. Check with your doctor before using NSAIDs, if you have diabetes. You may still be able to use them, but you may need to follow your blood sugars closely and, with the help of your doctor, adjust your diabetes medications appropriately. The elderly are at increased risk for side effects such as kidney damage and peptic ulcers from NSAIDs even at low doses. Consult with your doctor for an evaluation of your kidney function, to discuss your concerns about phosphorous in you urine, and for an appropriate course of action regarding the use of Naproxen. http://www. everydayhealth. com/drugs/naproxen http://www. everydayhealth. com/diabetes/type2/understanding. aspx

Q: If I take 500 mg of naproxen twice a day for 5 days as prescribed, can I get a hole in my stomach? Or is that only a long-term side effect? Can it happen in a few days?

A: Studies suggest that this is usually a long-term effect over the course of many months. But if a patient has existing stomach problems or if on multiple medications such as aspirin, other NSAIDs (Motrin, Advil, Aleve, etc.) stomach problems can be severe. Sometimes if physicians suspect stomach problems, they prescribe other medications to protect against it. Please consult with your physician prior to starting any new medications. Beena Thomas, PharmD

Q: I used to take Darvocet because I have sciatica pain and the doctor took me off of it and put me on Naproxen 500 mg twice daily. Now I am having shortness of breath and so tired I can hardly walk. I have been on this for one month. Could this medicine be causing me shortness of breath and the feeling of passing out?

A: Naproxen is a non-steroidal anti-inflammatory drug (or NSAID) that is used to treat pain and inflammation. The most common side effects of naproxen are heartburn, abdominal pain, nausea, constipation, headache, dizziness, drowsiness, itching, skin rashes, ringing of the ears, swelling, and shortness of breath. Naproxen, like other NSAIDs, may cause serious cardiovascular side effects, such as heart attack or stroke. Although serious cardiovascular events can occur without warning symptoms, patients should be aware of the signs and symptoms of chest pain, shortness of breath, weakness, slurring of speech, and should contact their health care provider if any of these occur. Michelle McDermott, PharmD

Q: What health effects does naproxen have on the kidneys?

A: As long as you have good kidney function and no liver disease, you can use naproxen. Your doctor should monitor your kidney function as long as you are on naproxen, however. The literature cites effects such as glomerular nephritis, hematuria, interstitial nephritis, nephrotic syndrome, nephropathy, and tubular necrosis. Since your doctor knows your medical condition, discuss any concerns you have about naproxen with him or her. For more information about naproxen, go to http://www. everydayhealth. com/drugs/naproxen. Gerald S. Levy, RPh

Q: I have rheumatoid arthritis and have been on Naproxen 500 mg once a day as a part of my treatment along with Enbrel 50 mg injection once a week and methotrexate 20 mg once a week. I've been stable on this protocol for the last four years. Recently, I've been having an increase in swelling of the feet/ankles that does not seem to resolve with decreasing salt intake or remaining in a cooler environment. I get a regular CBC and liver panel every three months and all is normal. Could the Naproxen be causing the swelling?

A: Naproxen is a medication used to treat pain and inflammation and is part of a class called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by blocking a hormone, called prostaglandin, that contributes to inflammation in the body. According to the prescribing information on Naproxen the most common side effects of this medication are: heartburn, nausea, constipation, headache, ringing in the ears, and fluid retention. These effects were seen in up to 3 percent of patients taking the medication during clinical trials. For more information on naproxen, visit http://www. everydayhealth. com/drugs/naproxen. If you feel you are experiencing fluid retention due to this medication, it would be best to consult with your physician to be sure that no other underlying condition is contributing to the problem. He or she will help you come up with a plan to deal with this issue. For more information on rheumatoid arthritis, visit http://www. everydayhealth. com/arthritis/rheumatoid-arthritis/index. aspx. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Lori Poulin, PharmD

Q: What is the difference between naproxen and Aleve? Is it true that you can't take both together?

A: Aleve is a brand name of naproxen, so they are the same. Naproxen is in a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by reducing hormones that cause inflammation and pain in the body. Naproxen is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendonitis, bursitis, gout, or menstrual cramps. Common side effects of naproxen include upset stomach, mild heartburn, stomach pain, diarrhea, constipation, bloating, gas, dizziness, headache, nervousness, blurred vision, and ringing in the ears. This is not a complete list of side effects that can occur with naproxen. Using NSAIDs can increase the risk of serious side effects, such as heart attack, stroke, and bleeding from the digestive tract. The risk of heart attack and stroke increase with long-term use of NSAIDS. Seek emergency medical attention if you experience chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance. Bleeding from the digestive tract can happen at any time during treatment with an NSAID. Contact your doctor right away if you have any symptoms of bleeding from the digestive tract, such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. Always read and follow the complete directions and warnings on over-the-counter medicines and discuss their use with your health care provider before taking them. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications. Sarah Lewis, PharmD

Q: Can naproxen be used for inflammation of the tooth?

A: Naprosyn (naproxen) is anti-inflammatory medication commonly used to treat mild to moderate pain, osteoarthritis, rheumatoid arthritis, headaches, and fever. Naprosyn (naproxen) could be used to relieve dental pain caused by inflammation and swelling. Common side effects of Naprosyn (naproxen) are constipation, diarrhea, abdominal pain, nausea, vomiting, heartburn, headache, dizziness, and drowsiness. This is not a complete list of possible side effects for Naprosyn (naproxen). Naprosyn (naproxen) should be taken with milk or food as prescribed by your physician. Naprosyn (naproxen) should not be taken with any other blood thinners (e. g. Coumadin) or other anti-inflammatory medication (e. g. Advil, Motrin, ibuprofen, or Aleve) unless directed by a physician. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Jennifer Carey, PharmD

Q: I've recently started suffering from osteoarthritis and have discovered that taking naproxen every day seems to keep the pain in check. What are the short - and long-term risks involved in taking naproxen every day?

A: Naproxen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by reducing hormones that cause inflammation and pain in the body and is used to treat conditions such as arthritis. Common side effects of naproxen include dizziness, drowsiness, stomach upset, mild heartburn, and rash. All NSAIDS can increase the risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use naproxen. Don't use this medicine just before or after having heart bypass surgery. Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance. NSAIDS can also increase the risk of serious effects on the stomach or intestines, including bleeding or perforation. These conditions can be fatal, and gastrointestinal effects can occur without warning at any time while you are taking naproxen. Older adults may have greater risk of these serious gastrointestinal side effects. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. Consult your health care provider for any specific concerns you have about using naproxen. For more information about this medication, go to http://www. everydayhealth. com/drugs/naproxen. Sarah Lewis, PharmD

Q: Does Naprelan have a generic equivalent?

A: Your question regards if Naprelan (naproxen) http://www. everydayhealth. com/drugs/naprelan-500 has a generic equivalent. To the best of my knowledge, there is no generic equivalent available for Naprelan. However, the active medication in Naprelan is naproxen. The medication Naprosyn http://www. everydayhealth. com/drugs/naprosyn also has naproxen as the active ingredient and that product is available in a generic. The medications have a different release into the body. Naprelan is usually dosed once daily, and it is a controlled release tablet while Naprosyn is dosed more often. As always, talk with your health care provider about questions you have about your medications. Jen Marsico, RPh

Q: Naproxen upsets my stomach. What else can I take for pain?

A: Over-the-counter medications for pain include non-steroidal anti-inflammatory drugs (NSAIDs) and the analgesic Tylenol (acetaminophen). Ibuprofen (Motrin, Advil) is an NSAID used for pain and inflammation. Doses of 200 to 400 mg every 4 to 6 hours or 1200 mg daily can be used over the counter. Naproxen (Aleve) is another over the counter NSAID. Naproxen can be taken at doses of 200 mg every 12 hours. NSAIDs should be avoided in patients with kidney or liver disease, patients with heart disease or a history of stomach ulcer or bleeding. Aspirin can also be considered an NSAID, but it should not be used in doses high enough to treat pain without the direction of a physician due to bleeding risks. Tylenol is an analgesic used to treat mild to moderate pain and fever. The maximum daily dose of Tylenol is 4000 mg (4 grams) daily. It is important to note that some prescription pain medications or cough and cold medications also contain acetaminophen. It is important to not take more than 4 grams of acetaminophen a day from all sources. Tylenol can affect the liver, so patients who already have liver damage should avoid taking Tylenol. Patients who drink more than 3 alcoholic drinks a day should also avoid taking Tylenol due to the increased risk of liver damage. Tylenol typically does not upset the stomach the way NSAIDs, such as naproxen, can. There are also many prescription pain medications available for moderate to severe pain that cannot be treated with an over-the-counter medication. If you have chronic pain or short term pain that is not relieved by over-the-counter medications, it is best to see your doctor who may evaluate your pain and decide to prescribe a pain medication. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Laura Cable, PharmD

Q: I've been taking naproxen for about 5 weeks. My doctor wants to give me a lower dose and have me take it one day on and two days off. His concern is that it will burn out my stomach. I have not had any adverse abdominal problems to date. The lower dose does not relieve enough of the pain to be worth it to me. Is this the best approach? Is there a test to check if there is a problem developing?

A: Naproxen (Naprosyn) is a non-steroidal anti-inflammatory drug (NSAID) that blocks substances in the body that normally cause pain and inflammation. Naproxen is indicated for pain associated with headache, cramps, and other pain. Naproxen is also used for pain and inflammation associated with arthritis and used as a fever reducer. Some of the common side effects associated with naproxen include constipation, diarrhea, headache, nausea, and stomach upset. According to the prescribing information, there are warnings associated with the use of naproxen. Long-term used of naproxen can increase the risk of serious cardiovascular events such as strokes and heart attacks. The risk of a serious adverse event can increase with the duration of treatment with naproxen. Naproxen should not be used just before or after coronary artery surgery. People with cardiovascular risk factors, those who are 60 years of age or older, have stomach ulcers or bleeding problems, take blood thinners or drink alcoholic drinks while taking naproxen are at a greater risk of a complication. Naproxen can increase the risk of serious stomach and intestine problems including bleeding or forming a hole (perforation). Talk to the doctor if signs and symptoms of bleeding occur. These symptoms include black, tarry or bloody stools or coughing up blood or vomit that looks like coffee grounds. Alcohol can increase the risk of stomach bleeding caused by naproxen. Avoid prolonged exposure to sunlight. Naproxen can worsen existing hypertension (high blood pressure), so talk to your doctor if you have hypertension. The lowest dose and shortest duration of treatment with NSAIDs for effective therapy is usually recommended. However, talk to your doctor if naproxen is not relieving the pain. Do not stop taking naproxen or take more medicine than what is prescribed. For more specific information and guidance on your current treatment based on your medical condition, consult with your healthcare provider. Kimberly Hotz, PharmD

Q: Does naproxen cause anemia?

A: Naproxen (Aleve, Naprosyn) belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by blocking substances in the body that cause pain and inflammation. Naproxen is used to treat fever, pain, and inflammation caused by a wide variety of conditions, including arthritis, bursitis, gout, headache, ankylosing spondylitis, tendonitis, menstrual cramps, and minor injuries. Common side effects of naproxen include nausea, stomach upset, heartburn, bloating, gas, diarrhea, constipation, dizziness, drowsiness, blurred vision, and ringing in the ears. A search of a drug database shows that anemia can occur in up to 10 percent of patients taking NSAIDs, including naproxen. This would be considered a frequent or common side effect. Consult with your doctor if you are concerned about anemia or if you are experiencing symptoms of anemia, such as fatigue, pale skin, coldness, or dizziness. This is not a complete list of risks or side effects that can occur with naproxen or any other NSAID. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications, particularly before taking any action. Sarah Lewis, PharmD

Q: Does naproxen affect bowel movements?

A: Naproxen (Aleve, Naprosyn) is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain and inflammation in a variety of conditions, including arthritis and gout. Naproxen and other NSAIDs can be irritating to the stomach, causing inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large intestine. To reduce the risk of gastrointestinal side effects, patients should receive the lowest effective dose of naproxen for the shortest period of time to adequately relieve symptoms. Other gastrointestinal side effects include nausea, diarrhea, constipation, and abdominal pain. If you think you are experiencing a side effect from your medication, talk to your doctor. Do not stop or change your medication unless your doctor directs you to do so. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Michelle McDermott, PharmD

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Ranitidine is used for treating certain conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It is also used to treat ulcers of the small intestine that have not responded to other treatment. It may be used as a short-term alternative to oral ranitidine, in patients who are not able to take medicine by mouth. Ranitidine is an H 2 - receptor blocker. It works by blocking the action of histamine in the stomach. This reduces the amount of acid the stomach makes. Reducing stomach acid helps to reduce heartburn, heal irritation of the esophagus, and heal ulcers of the stomach or intestines.

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You may take antacids while you are using Ranitidine if you are directed to do so by your doctor.

Continue to use Ranitidine even if you feel well. Do not miss any dose.

If you miss a dose of Ranitidine, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ranitidine.

Store Ranitidine between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ranitidine out of the reach of children and away from pets.

Do NOT use Ranitidine if:

you are allergic to any ingredient in Ranitidine

you have a history of the blood disease porphyria

you are taking dasatinib.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Ranitidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems

if you have abnormal blood electrolyte levels or a history of irregular heartbeat.

Some medicines may interact with Ranitidine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Certain benzodiazepines (eg, midazolam, triazolam), glipizide, procainamide, or warfarin because the risk of their side effects may be increased by Ranitidine

Dasatinib, delavirdine, gefitinib, certain HIV protease inhibitors (eg, atazanavir), itraconazole, or ketoconazole because their effectiveness may be decreased by Ranitidine.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ranitidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Ranitidine may rarely cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ranitidine with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Ranitidine may interfere with certain lab tests, including urine protein tests. Be sure your doctor and lab personnel know you are taking Ranitidine.

Lab tests, including liver function, may be performed while you use Ranitidine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Ranitidine should be used with extreme caution in children younger than 1 month old; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ranitidine while you are pregnant. Ranitidine is found in breast milk. Do not breastfeed while taking Ranitidine.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; headache; nausea; stomach upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); change in the amount of urine produced; confusion; dark urine; depression; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; severe or persistent headache or stomach pain; unusual bruising or bleeding; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Ranitidine is used for treating certain conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It is also used to treat ulcers of the small intestine that have not responded to other treatment. It may be used as a short-term alternative to oral ranitidine, in patients who are not able to take medicine by mouth. Ranitidine is an H 2 - receptor blocker. It works by blocking the action of histamine in the stomach. This reduces the amount of acid the stomach makes. Reducing stomach acid helps to reduce heartburn, heal irritation of the esophagus, and heal ulcers of the stomach or intestines.

Use Ranitidine as directed by your doctor.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

You may take antacids while you are using Ranitidine if you are directed to do so by your doctor.

Continue to use Ranitidine even if you feel well. Do not miss any dose.

If you miss a dose of Ranitidine, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ranitidine.

Store Ranitidine between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ranitidine out of the reach of children and away from pets.

Do NOT use Ranitidine if:

you are allergic to any ingredient in Ranitidine

you have a history of the blood disease porphyria

you are taking dasatinib.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Ranitidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems

if you have abnormal blood electrolyte levels or a history of irregular heartbeat.

Some medicines may interact with Ranitidine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Certain benzodiazepines (eg, midazolam, triazolam), glipizide, procainamide, or warfarin because the risk of their side effects may be increased by Ranitidine

Dasatinib, delavirdine, gefitinib, certain HIV protease inhibitors (eg, atazanavir), itraconazole, or ketoconazole because their effectiveness may be decreased by Ranitidine.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ranitidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Ranitidine may rarely cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ranitidine with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Ranitidine may interfere with certain lab tests, including urine protein tests. Be sure your doctor and lab personnel know you are taking Ranitidine.

Lab tests, including liver function, may be performed while you use Ranitidine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Ranitidine should be used with extreme caution in children younger than 1 month old; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ranitidine while you are pregnant. Ranitidine is found in breast milk. Do not breastfeed while taking Ranitidine.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; headache; nausea; stomach upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); change in the amount of urine produced; confusion; dark urine; depression; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; severe or persistent headache or stomach pain; unusual bruising or bleeding; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Metazol 200 Mg Tablets; Metazol 400 Mg Tablets, Metazole

PROPRIETARY NAME (and dosage form):

METAZOL 200 mg TABLETS METAZOL 400 mg TABLETS

COMPOSITION: Metronidazole 200 mg and 400 mg per tablet respectively.

PHARMACOLOGICAL CLASSIFICATION: A20.2.6 Medicines against protozoa.

PHARMACOLOGICAL ACTION: Metronidazole has antiprotozoal and antibacterial actions and is directly trichomonacidal and amoebicidal and bactericidal in vitro for many anaerobic micro-organisms including Bacteroides species.

INDICATIONS: 1. Trichomonas infections in both males and females. 2. All forms of amoebiasis. 3. Lambliasis and Vincent's infection. 4. Treatment of infections in which anaerobic bacteria have been identified or are suspected as pathogens, particularly Bacteroides fragilis and other species of Bacteroides, and including other species for which metronidazole is bactericidal. 5. Prevention of post operative infections due to anaerobic bacteria.

CONTRA-INDICATIONS: Metronidazole should not be used in patients with blood dyscrasias or with active disease of the central nervous system. Its use should be avoided during pregnancy.

DOSAGE AND DIRECTIONS FOR USE: Seven days treatment should be satisfactory for most patients. Prolonged treatment can be used if the physician considers it to be necessary. 1 . Treatment of anaerobic infections Adults and children over 12 years: 400 mg three times daily. Children under 12 years: 7,5 mg per kg body mass three times daily.

2. Prevention of anaerobic infections GYNAECOLOGICAL SURGERY Adults: 2 g as a single dose followed by 200 mg three times daily until pre-operative withholding of solids and liquids by mouth becomes necessary. Medication with 200 mg three times daily should be resumed after the operation and for up to seven days.

3. Vincent's infection Adults and children over 12 years: 200 mg three times daily for three days or 400 mg orally morning and evening for three days.

4. Treatment of trichomonas infections (To prevent re-infection the consort should receive similar courses of treatment concurrently.) Adults and children over 12 years: Either 200 mg three times daily for seven day. Or 800 mg mornings and 1,2 g evenings for two days. Or a single 2 g oral dose.

5. Treatment of Amoebic infections Adults and children over 12 years: 800 mg three times daily for 5 - 10 days.

6. Treatment of Lambliasis Adults and children over 12 years: 2 g once daily for three days.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS: Side effects of Metronidazole include gastro-intestinal discomfort, anorexia, nausea, coated tongue, dryness of mouth and unpleasant taste, headaches and skin rashes; vomiting, diarrhoea, weakness, vertigo, depression, insomnia, drowsiness, urethral discomfort and darkening of the urine. There may be a temporary decrease in the white-cell count. Peripheral neuropathy has been reported in patients on prolonged therapy. When given in conjunction with alcohol Metronidazole may provoke a disulfiram-like reaction. Metronidazole enhances the anti-coagulant effect of warfarin. Pseudomembranous colitis has been reported with the use of Metronidazole.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT: Symptoms: Nausea, diarrhoea, epigastric pain, abdominal cramps, metallic taste and furry tongue. Dizziness, vertigo, ataxia. Treatment: Supportive and symptomatic therapy.

CONDITIONS OF REGISTRATION: Advertising to the professions only.

IDENTIFICATION: A) 200 mg: White, round, biconvex, uncoated tablet with a dividing groove on one side with a diameter of 11,5 mm. B) 400 mg: White, round, flat uncoated tablet with a dividing groove on one side and a "11/400" inscription on the other, with a diameter of 12,5 mm.

PRESENTATION: 200 mg: Containers of 1000 tablets. 400 mg: Containers of 1000 tablets.

STORAGE INSTRUCTIONS: Store in a cool place (Below 25°C) Protect from light. KEEP OUT OF REACH OF CHILDREN.

REGISTRATION NUMBERS: 200 mg strength: W/20.2.6/63. 400 mg strength: W/20.2.6/64.

NAME AND BUSINESS ADDRESS OF THE APPLICANT: Geo Schwulst Laboratories Limited Needham Park 1 Manchester Road Wadeville

DATE OF PUBLICATION OF THIS PACKAGE INSERT: October 1988



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What Is Omeprazole Used For, Loseprazol

What Is Omeprazole Used For?

Some of the uses of omeprazole include the treatment of such conditions as gastroesophageal reflux disease (GERD), gastric ulcers, duodenal ulcers, pathological hypersecretory conditions, and H. pylori infections. On occasion, a healthcare provider may prescribe omeprazole off-label to prevent stomach ulcers in people taking nonsteroidal anti-inflammatory drugs (NSAIDs). Prescription omeprazole uses are approved for children as young as one year of age.

Uses of Omeprazole: An Overview

Omeprazole (Prilosec ® ) is a prescription medication used to treat several conditions related to the esophagus, stomach, and intestines. Omeprazole is part of a class of drugs known as proton pump inhibitors (PPIs). Nonprescription omeprazole magnesium (Prilosec OTC ® ) is also available and is approved to treat frequent heartburn (that occurs at least twice a week).

Specific uses for prescription omeprazole include treating:

Duodenal ulcers (ulcers in the very first part of the intestine after the stomach).

Helicobacter pylori infections associated with duodenal ulcers -- omeprazole is used in combination with antibiotics to eliminate H. pylori bacteria in the stomach, helping to heal duodenal ulcers.

Benign (noncancerous) gastric ulcers (or stomach ulcers).

Gastroesophageal reflux disease (GERD ) -- omeprazole helps to treat GERD by relieving heartburn and healing esophagitis (damage to the esophagus).

Pathological hypersecretory conditions -- omeprazole helps to treat these conditions (when too much stomach acid is produced), such as Zollinger-Ellison syndrome.



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Viagra - Erectile Dysfunction, Betnoval G

Common use The main component of Viagra is Sildenafil Citrate. Sildenafil Citrate affects the response to sexual stimulation. It acts by enhancing smooth muscle relaxation using nitric oxide, a chemical that is normally released in response to sexual stimulation. This smooth muscle relaxation allows increased blood flow into certain areas of the penis, which leads to an erection. Sildenafil Citrate is applied for the treatment of erectile dysfunction (impotence) in men and pulmonary arterial hypertension. Sildenafil Citrate may also be used for other purposes not listed above.

Dosage and direction Usually the recommended dose is 50 mg. It is taken approximately 0,5-1 hour before sexual activity. Do not take Viagra more then once a day. A high fat meal may delay the time of the effect of this drug. Try not to eat grapefruit or drink grapefruit juice while you are being treated with Sildenafil Citrate .

Precautions Before you start taking Sildenafil Citrate. tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Aged people may be more sensitive to the side effects of the drug.

Viagra is contraindicated in patients who take another medicine to treat impotence or using a nitrate drug for chest pain or heart problems. This medicine should not be taken by women and children as well as in patients with a known hypersensitivity to any component of the tablet.

Possible side effect The most common side effects are headache, flushing, heartburn, stomach upset, nasal stuffiness, lightheadedness, dizziness or diarrhea. A serious allergic reaction to this drug is very rare, but seek immediate medical help if it occurs. Many people who use this medicine do not have serious side effects. In case you notice any side effects not listed above, contact your doctor or pharmacist.

Drug interaction This drug should not be used with nitrates and recreational drugs called "poppers" containing amyl or butyl nitrite; alpha-blocker medications; other medications for impotence; high blood pressure medicines, etc. Consult your doctor or pharmacist for more details.

Missed dose Viagra is used as needed, so you are unlikely to be on a dosing schedule.

Overdose If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store the drugs in the bathroom. Keep all drugs away from reach of children and pets.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.



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Ketipinor (Quetiapine) Report For Patients Like You, Ketipinor

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What is quetiapine?

Quetiapine is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Quetiapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression).

Quetiapine may also be used for purposes other than those listed in this medication guide.

Precautions

Quetiapine is not for use in psychotic conditions related to dementia. Quetiapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Before you take quetiapine, tell your doctor if you have:

liver or kidney disease;

heart disease, high blood pressure, heart rhythm problems;

a history of heart attack or stroke;

a thyroid disorder;

seizures or epilepsy;

high cholesterol or triglycerides;

a personal or family history of diabetes; or

trouble swallowing.

If you have any of these conditions, you may not be able to use quetiapine, or you may need a dosage adjustment or special tests during treatment.

Quetiapine may cause you to have high blood sugar (hyperglycemia). Talk to your doctor if you have any signs of hyperglycemia such as increased thirst or urination, excessive hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis while you are taking quetiapine.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether quetiapine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give quetiapine to anyone younger than 18 years old without the advice of a doctor.

Quetiapine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol, which can increase some of the side effects of quetiapine.

Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by quetiapine. Tell your doctor if you need to use any of these other medicines while you are taking quetiapine.

Instructions

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include extreme drowsiness, fast heart rate, feeling light-headed, or fainting.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Other serious side effects include:

fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;

jerky muscle movements you cannot control;

sudden numbness or weakness, especially on one side of the body;

sudden headache, confusion, problems with vision, speech, or balance;

increased thirst, frequent urination, excessive hunger, or weakness;

feeling like you might pass out; or

urinating less than usual or not at all.

Less serious side effects may include:

dizziness, drowsiness, or weakness;

dry mouth, runny nose, sore throat;

nausea, vomiting, stomach pain, constipation;

blurred vision, headache, anxiety, agitation;

breast swelling or discharge;

missed menstrual periods; or

weight gain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Interactions

Before taking quetiapine, tell your doctor if you are taking any of the following medicines:

cimetidine (Tagamet);

erythromycin (E-Mycin, E. E.S, Ery-Tab);

lorazepam (Ativan);

rifabutin (Mycobutin) or rifampin (Rifadin, Rimactane, Rifater);

steroids (prednisone and others);

thioridazine (Mellaril);

an antifungal medication such as fluconazole (Diflucan), ketoconazole (Nizoral), or itraconazole (Sporanox);

medicine for depression or mental illness, such as fluoxetine (Prozac), haloperidol (Haldol), imipramine (Tofranil), or risperidone (Risperdal);

a medication to treat high blood pressure or a heart condition; or

seizure medication such as carbamazepine (Tegretol), divalproex (Depakote), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin), or valproate (Depakene).

This list is not complete and there may be other drugs that can interact with quetiapine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

Seroquel, quetiapine, and Seroquel XR

Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

Last updated: September 19, 2016

What is the most important information I should know about quetiapine?

Quetiapine is not for use in psychotic conditions related to dementia. Quetiapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Stop using quetiapine and call your doctor at once if you have the following symptoms: fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, uncontrolled muscle movements, symptoms that come on suddenly such as numbness or weakness, severe headache, and problems with vision, speech, or balance.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Warning

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.



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Terazosin Indications, Side Effects, Warnings, Terazosab

Terazosin

Treating high blood pressure and treating signs and symptoms of benign prostatic hyperplasia (BPH).

Terazosin is an alpha-blocker. It works by relaxing muscles in the blood vessels, resulting in lowering of blood pressure. In BPH, alpha-blockers work by relaxing muscles around the urethra (tube that drains urine from the bladder), which improves urinary symptoms.

Do NOT use terazosin if:

you are allergic to any ingredient in terazosin or to similar medicines (eg, prazosin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using terazosin:

Some medical conditions may interact with terazosin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have prostate cancer, angina pectoris, heart disease, or kidney or liver problems

if you will be having eye surgery

Some MEDICINES MAY INTERACT with terazosin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Phosphodiesterase type 5 (PDE5) inhibitors (eg, sildenafil) or verapamil because severe dizziness, lightheadedness, or fainting may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if terazosin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use terazosin:

Use terazosin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take terazosin by mouth with or without food.

Terazosin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly.

If you miss a dose of terazosin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use terazosin.

Important safety information:

Terazosin may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use terazosin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using terazosin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Terazosin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. This will help to reduce your lightheadedness or dizziness. These effects are more likely to occur after the first few doses or if your dose has increased, but can occur at any time while you are taking the medicine. It can also occur if you stop taking the medicine and then restart treatment.

Terazosin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

Do NOT take more than the recommended dose without checking with your doctor.

Terazosin may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.

Tell your doctor or dentist that you take terazosin before you receive any medical or dental care, emergency care, or surgery (including eye surgery).

Lab tests, including blood pressure, may be performed while you use terazosin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Terazosin should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using terazosin while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use terazosin, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of terazosin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; lightheadedness; nasal congestion; nausea; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; chest pain; decreased sexual desire or ability; fainting; fast, slow, or irregular heartbeat;painful, prolonged erection; severe or prolonged dizziness or headache; shortness of breath; swelling of the ankles, feet, or hands.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately. Symptoms may include dizziness; weakness.

Proper storage of terazosin:

Store terazosin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep terazosin out of the reach of children and away from pets.

General information:

If you have any questions about terazosin, please talk with your doctor, pharmacist, or other health care provider.

Terazosin is to be used only by the patient for whom it is prescribed. Do not share it with other people. Do not use it for other health conditions.

If your symptoms do not improve or if they become worse, check with your doctor.

If using terazosin for an extended period of time, obtain refills before your supply runs out.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take terazosin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about terazosin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to terazosin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using terazosin.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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Oftaler, Oftaler

En adultos y niños mayores de 3 años: Instilar 1 gota en el (los) ojo (s) afectado (s) de solución oftálmica cada 8 - 12 horas.

En adultos: Instilar 1 a 2 gotas en el (los) ojo (s) afectado (s) de solución oftálmica 2 a 4 veces al día.

Cada 100 mL de SOLUCIÓN OFTÁLMICA contiene: Ketotifeno 0,025 g (como fumarato). Excipientes c. s.

Cada 100 mL de SOLUCIÓN OFTÁLMICA contiene:

Ketotifeno 0,050 g (como fumarato). Excipientes c. s.

Está contraindicado en hipersensibilidad a los principios activos.

OFTALER 0,025% no se recomienda administrar a niños menores de 3 años.

No se ha estudiado su efecto durante el embarazo y la lactancia.

Alivio de los síntomas y signos (picazón) de la conjuntivitis alérgica.

PRESENTACIÓN: Frasco con 10 mL de solución oftálmica .

Av. Pdte. Eduardo Frei Montalva 4.600 - Renca Telf. 707-3000 Fax: 736-3674

Paraguay

OFTALER COLIRIO

ComposiciпїЅn.

Cada 100ml de soluciпїЅn oftпїЅlmica contienen: ketotifeno 0,05g (0,05%).

FarmacologпїЅa.

OFTALER es ketotifeno fumarato, un derivado del benzocicloheptatiofeno con actividad antihistamпїЅnica y antialпїЅrgica potente, posee un efecto terapпїЅutico rпїЅpido y de larga duraciпїЅn. OFTALER actпїЅa inhibiendo la liberaciпїЅn de mediadores quпїЅmicos de mastocitos sensibilizados y leucocitos, aunque otros mecanismos pueden estar implicados como antiquimiotпїЅctico de eosinпїЅfilos. OFTALER tambiпїЅn posee propiedades bloqueantes de histamina, pues es un antagonista relativamente selectivo, no competitivo de histamina (receptor-H1). OFTALER actпїЅa en las fases temprana y tardпїЅa del proceso alпїЅrgico: bloquea receptores H1 de histamina, estabiliza mastocitos y basпїЅfilos, inhibe la quimiotaxis y activaciпїЅn de eosinпїЅfilos e inhibe la liberaciпїЅn y/o acciпїЅn de varios mediadores implicados en la inflamaciпїЅn alпїЅrgica. Existe evidencia de que ketotifeno puede tener un efecto inmunomodulador sobre cпїЅlulas presentadoras de antпїЅgeno y sobre los linfocitos T. Al inhibir la actividad de fosfolipasa A2, reduce la liberaciпїЅn de пїЅcido araquidпїЅnico de los fosfolпїЅpidos de membrana y la producciпїЅn de leucotrienos y prostaglandinas, que se sabe son potentes mediadores proinflamatorios en el proceso alпїЅrgico. Sus acciones favorables sobre varias vпїЅas de la alergia ocular hacen que OFTALER posea un perfil antialпїЅrgico пїЅnico cuando se lo compara con otras alternativas existentes como los antihistamпїЅnicos y los estabilizadores de mastocitos.

Indicaciones.

Alivio de los signos y sпїЅntomas de la conjuntivitis alпїЅrgica.

DosificaciпїЅn.

Dosis usual: instilar 1 a 2 gotas de soluciпїЅn oftпїЅlmica dos veces al dпїЅa.

Contraindicaciones.

Hipersensibilidad conocida al principio activo.

Reacciones adversas.

En general es bien tolerado. Se ha informado reacciones transitorias de ardor en el ojo. Raramente se producen otras manifestaciones de irritaciпїЅn local como congestiпїЅn, inflamaciпїЅn o picazпїЅn. Si se produce blefaritis y dermatitis en el pпїЅrpado, el tratamiento debe suspenderse. Las bajas dosis utilizadas no producen somnolencia.

Precauciones.

Previo a la instilaciпїЅn del fпїЅrmaco, los lentes de contacto deben ser removidos; pueden volver a colocarse luego de 15 minutos. Los pacientes con visiпїЅn borrosa transitoria deberпїЅan evitar conducir vehпїЅculos u operar maquinarias. Como en toda soluciпїЅn oftalmica, el uso de OFTALER debe considerar las precauciones habituales: sпїЅlo para uso oftпїЅlmico tпїЅpico; despuпїЅs de su uso tapar inmediatamente; evпїЅtese el contacto directo de la punta del gotario con el globo ocular; mantпїЅngase alejado del alcance de los niпїЅos. Embarazo y lactancia: los estudios en animales con ketotifeno sistпїЅmico no mostraron potencial embriotпїЅxico o teratogпїЅnico. Sin embargo, no hay estudios al respecto en humanos por lo que no se recomienda su uso en estas circunstancias.

Interacciones.

No se han descrito.

SobredosificaciпїЅn.

No se ha descrito.

PresentaciпїЅn.

Chile

OFTALER

ComposiciпїЅn.

Cada 100 ml de soluciпїЅn oftпїЅlmica contiene: Ketotifeno (Como fumarato) 0,025 g (0,025%). Excipientes c. s.

FarmacologпїЅa.

OFTALER es ketotifeno fumarato, un derivado del benzocicloheptatiofeno con actividad antihistamпїЅnica y antialпїЅrgica potente, posee un efecto terapпїЅutico rпїЅpido y de larga duraciпїЅn. OFTALER actпїЅa inhibiendo la liberaciпїЅn de mediadores quпїЅmicos de mastocitos sensibilizados y leucocitos, aunque otros mecanismos pueden estar implicados como antiquimiotпїЅctico de eosinпїЅfilos. OFTALER tambiпїЅn posee propiedades bloqueantes de histamina, pues es un antagonista relativamente selectivo, no competitivo de histamina (receptor-H1). OFTALER actпїЅa en las fases temprana y tardпїЅa del proceso alпїЅrgico: bloquea receptores H1 de histamina, estabiliza mastocitos y basпїЅfilos, inhibe la quimiotaxis y activaciпїЅn de eosinпїЅfilos e inhibe la liberaciпїЅn y/o acciпїЅn de varios mediadores implicados en la inflamaciпїЅn alпїЅrgica. Existe evidencia de que ketotifeno puede tener un efecto inmunomodulador sobre cпїЅlulas presentadoras de antпїЅgeno y sobre los linfocitos T. Al inhibir la actividad de fosfolipasa A2, reduce la liberaciпїЅn de пїЅcido araquidпїЅnico de los fosfolпїЅpidos de membrana y la producciпїЅn de leucotrienos y prostaglandinas, que se sabe son potentes mediadores proinflamatorios en el proceso alпїЅrgico. Sus acciones favorables sobre varias vпїЅas de la alergia ocular hacen que OFTALER posea un perfil antialпїЅrgico пїЅnico cuando se lo compara con otras alternativas existentes como los antihistamпїЅnicos y los estabilizadores de mastocitos.

Indicaciones.

Alivio de los signos y sпїЅntomas de la conjuntivitis alпїЅrgica.

DosificaciпїЅn.

Dosis usual: instilar 1 a 2 gotas de soluciпїЅn oftпїЅlmica dos veces al dпїЅa.

Contraindicaciones.

Hipersensibilidad conocida al principio activo.

Reacciones adversas.

En general es bien tolerado. Se ha informado reacciones transitorias de ardor en el ojo. Raramente se producen otras manifestaciones de irritaciпїЅn local como congestiпїЅn, inflamaciпїЅn o picazпїЅn. Si se produce blefaritis y dermatitis en el pпїЅrpado, el tratamiento debe suspenderse. Las bajas dosis utilizadas no producen somnolencia.

Precauciones.

Previo a la instilaciпїЅn del fпїЅrmaco, los lentes de contacto deben ser removidos; pueden volver a colocarse luego de 15 minutos. Los pacientes con visiпїЅn borrosa transitoria deberпїЅan evitar conducir vehпїЅculos u operar maquinarias. Como en toda soluciпїЅn oftalmica, el uso de OFTALER debe considerar las precauciones habituales: sпїЅlo para uso oftпїЅlmico tпїЅpico; despuпїЅs de su uso tapar inmediatamente; evпїЅtese el contacto directo de la punta del gotario con el globo ocular; mantпїЅngase alejado del alcance de los niпїЅos. Embarazo y lactancia:Los estudios en animales con ketotifeno sistпїЅmico no mostraron potencial embriotпїЅxico o teratogпїЅnico. Sin embargo, no hay estudios al respecto en humanos por lo que no se recomienda su uso en estas circunstancias.

Interacciones.

No se ha descrito.

SobredosificaciпїЅn.

No se ha descrito.

PresentaciпїЅn.

Frasco gotario sellado con 10 ml de soluciпїЅn oftпїЅlmica estпїЅril al 0,025%.

OFTALER

SAVAL-NICOLICH

Forte

ComposiciпїЅn.

Cada 100 ml de soluciпїЅn oftпїЅlmica contiene: Ketotifeno (Como fumarato) 0,05 g (0,05%). Excipientes c. s.

FarmacologпїЅa.

OFTALER es ketotifeno fumarato, un derivado del benzocicloheptatiofeno con actividad antihistamпїЅnica y antialпїЅrgica potente, posee un efecto terapпїЅutico rпїЅpido y de larga duraciпїЅn. OFTALER actпїЅa inhibiendo la liberaciпїЅn de mediadores quпїЅmicos de mastocitos sensibilizados y leucocitos, aunque otros mecanismos pueden estar implicados como antiquimiotпїЅctico de eosinпїЅfilos. OFTALER tambiпїЅn posee propiedades bloqueantes de histamina, pues es un antagonista relativamente selectivo, no competitivo de histamina (receptor-H1). OFTALER actпїЅa en las fases temprana y tardпїЅa del proceso alпїЅrgico: bloquea receptores H1 de histamina, estabiliza mastocitos y basпїЅfilos, inhibe la quimiotaxis y activaciпїЅn de eosinпїЅfilos e inhibe la liberaciпїЅn y/o acciпїЅn de varios mediadores implicados en la inflamaciпїЅn alпїЅrgica. Existe evidencia de que ketotifeno puede tener un efecto inmunomodulador sobre cпїЅlulas presentadoras de antпїЅgeno y sobre los linfocitos T. Al inhibir la actividad de fosfolipasa A2, reduce la liberaciпїЅn de пїЅcido araquidпїЅnico de los fosfolпїЅpidos de membrana y la producciпїЅn de leucotrienos y prostaglandinas, que se sabe son potentes mediadores proinflamatorios en el proceso alпїЅrgico. Sus acciones favorables sobre varias vпїЅas de la alergia ocular hacen que OFTALER posea un perfil antialпїЅrgico пїЅnico cuando se lo compara con otras alternativas existentes como los antihistamпїЅnicos y los estabilizadores de mastocitos.

Indicaciones.

Alivio de los signos y sпїЅntomas de la conjuntivitis alпїЅrgica.

DosificaciпїЅn.

Dosis usual: instilar 1 a 2 gotas de soluciпїЅn oftпїЅlmica dos veces al dпїЅa.

Contraindicaciones.

Hipersensibilidad conocida al principio activo.

Reacciones adversas.

En general es bien tolerado. Se ha informado reacciones transitorias de ardor en el ojo. Raramente se producen otras manifestaciones de irritaciпїЅn local como congestiпїЅn, inflamaciпїЅn o picazпїЅn. Si se produce blefaritis y dermatitis en el pпїЅrpado, el tratamiento debe suspenderse. Las bajas dosis utilizadas no producen somnolencia.

Precauciones.

Previo a la instilaciпїЅn del fпїЅrmaco, los lentes de contacto deben ser removidos; pueden volver a colocarse luego de 15 minutos. Los pacientes con visiпїЅn borrosa transitoria deberпїЅan evitar conducir vehпїЅculos u operar maquinarias. Como en toda soluciпїЅn oftalmica, el uso de OFTALER debe considerar las precauciones habituales: sпїЅlo para uso oftпїЅlmico tпїЅpico; despuпїЅs de su uso tapar inmediatamente; evпїЅtese el contacto directo de la punta del gotario con el globo ocular; mantпїЅngase alejado del alcance de los niпїЅos. Embarazo y lactancia:Los estudios en animales con ketotifeno sistпїЅmico no mostraron potencial embriotпїЅxico o teratogпїЅnico. Sin embargo, no hay estudios al respecto en humanos por lo que no se recomienda su uso en estas circunstancias.

Interacciones.

No se ha descrito.

SobredosificaciпїЅn.

No se ha descrito.

PresentaciпїЅn.



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Enzimar Snc Di D Erasmo Marino E Peroni Enzo In Grottammare, Ascoli Piceno, Enzimar

ENZIMAR SNC DI D'ERASMO MARINO E PERONI ENZO

Basic data of ENZIMAR SNC DI D'ERASMO MARINO E PERONI ENZO

The company ENZIMAR SNC DI D'ERASMO MARINO E PERONI ENZO is situated in the province Ascoli Piceno, in the city GROTTAMMARE and its postal address is STRADA PROVINCIALE VALTESINO, 102, 63013, GROTTAMMARE, Ascoli Piceno.

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Company´s activity ENZIMAR SNC DI D'ERASMO MARINO E PERONI ENZO is Rivestimento di pavimenti e di muri.

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Co-Amoxiclav 500mg, Julmentin

CO-AMOXICLAV 500MG/125MG TABLETS

Transcript

Augmentin 625mg Tablets (amoxicillin / clavulanic acid) Patient Information Leaflet Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. * Keep this leaflet. You may need to read it again. * If you have any further questions, ask your doctor or pharmacist. * This medicine has been prescribed for you (or for your child). Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. * If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. Your medicine is called Augmentin 625mg Tablets but will be referred to as Augmentin throughout this Patient Information Leaflet. What is in this leaflet: 1

What Augmentin is and what it is used for

What you need to know before you take Augmentin

How to take Augmentin

Possible side effects

How to store Augmentin

Contents of the pack and other information

What Augmentin is and what it is used for

Augmentin is an antibiotic and works by killing bacteria that cause infections. It contains two different medicines called amoxicillin and clavulanic acid. Amoxicillin belongs to a group of medicines called “penicillins” that can sometimes be stopped from working (made inactive). The other active component (clavulanic acid) stops this from happening. Augmentin is used in adults and children to treat the following infections: * middle ear and sinus infections * respiratory tract infections * urinary tract infections * skin and soft tissue infections including dental infections * bone and joint infections.

Pregnancy, breast-feeding and fertility If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Driving and using machines Augmentin can have side effects and the symptoms may make you unfit to drive. Do not drive or operate machinery unless you are feeling well.

What you need to know before you take Augmentin

Do not take Augmentin: * if you are allergic to amoxicillin, clavulanic acid, penicillin or any of the other ingredients of this medicine (listed in section 6) * if you have ever had a severe allergic (hypersensitive) reaction to any other antibiotic. This can include a skin rash or swelling of the face or neck * if you have ever had liver problems or jaundice (yellowing of the skin) when taking an antibiotic. ? Do not take Augmentin if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Augmentin. Warnings and Precautions Talk to your doctor or pharmacist before taking Augmentin if you: * have glandular fever * are being treated for liver or kidney problems * are not passing water regularly. If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Augmentin. In some cases, your doctor may investigate the type of bacteria that is causing your infection. Depending on the results, you may be given a different strength of Augmentin or a different medicine. Conditions you need to look out for Augmentin can make some existing conditions worse, or cause serious side effects. These include allergic reactions, convulsions (fits) and inflammation of the large intestine. You must look out for certain symptoms while you are taking Augmentin, to reduce the risk of any problems. See ‘Conditions you need to look out for’ in Section 4. Blood and urine tests If you are having blood tests (such as red blood cell status tests or liver function tests) or urine tests (for glucose), let the doctor or nurse know that you are taking Augmentin. This is because Augmentin can affect the results of these type of tests. Other medicines and Augmentin Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines. * If you are taking allopurinol (used for gout) with Augmentin, it may be more likely that you will have an allergic skin reaction. * If you are taking probenecid (used for gout), your doctor may decide to adjust your dose of Augmentin. * If medicines to help stop blood clots (such as warfarin) are taken with Augmentin then extra blood tests may be needed. * Augmentin can affect how methotrexate (a medicine used to treat cancer or rheumatic diseases) works.

How to take Augmentin

Always take Augmentin exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. Adults and children weighing 40 kg and over The usual dose is: * 1 tablet three times a day Children weighing less than 40 kg Children aged 6 years or less should preferably be treated with Augmentin oral suspension or sachets. Ask your doctor or pharmacist for advice when giving Augmentin tablets to children weighing less than 40 kg. The tablets are not suitable for children weighing less than 25 kg. Patients with kidney and liver problems * If you have kidney problems the dose might be changed. A different strength or a different medicine may be chosen by your doctor. * If you have liver problems you may have more frequent blood tests to see how your liver is working. How to take Augmentin

* Swallow the tablets whole with a glass of water at the start of a meal or

Augmentin may affect how mycophenolate mofetil (a medicine used to prevent the rejection of transplanted organs) works.

slightly before. Tablets can be broken along the score line to make them easier to swallow. You must take both pieces of the tablet at the same time. Space the doses evenly during the day, at least 4 hours apart. Do not take 2 doses in 1 hour. Do not take Augmentin for more than 2 weeks. If you still feel unwell you should go back to see the doctor.

If you take more Augmentin than you should If you have too much Augmentin, signs might include an upset stomach (feeling sick, being sick or diarrhoea) or convulsions. Talk to your doctor as soon as possible. Take the medicine carton or bottle to show the doctor. If you forget to take Augmentin

* If you forget to take a dose, take it as soon as you remember. * You should not take the next dose too soon, but wait about 4 hours before

taking the next dose. Do not take a double dose to make up for a forgotten dose.

If you stop taking Augmentin Keep taking Augmentin until the treatment is finished, even if you feel better. You need every dose to help fight the infection. If some bacteria survive they can cause the infection to come back. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Conditions you need to look out for Allergic reactions: * skin rash * inflammation of blood vessels (vasculitis) which may be visible as red or purple raised spots on the skin, but can affect other parts of the body * fever, joint pain, swollen glands in the neck, armpit or groin * swelling, sometimes of the face or mouth (angioedema), causing difficulty in breathing * collapse. ? Contact a doctor immediately if you get any of these symptoms. Stop taking Augmentin. Inflammation of large intestine Inflammation of the large intestine, causing watery diarrhoea usually with blood and mucus, stomach pain and/or fever. ? Contact your doctor as soon as possible for advice if you get these symptoms.

Augmentin 625mg Tablets (amoxicillin / clavulanic acid) Patient Information Leaflet (continued) Very common side effects These may affect more than 1 in 10 people * diarrhoea (in adults). Common side effects These may affect up to 1 in 10 people (candida - a yeast infection of the vagina, mouth or skin folds) * thrush sick (nausea), especially when taking high doses *?feeling if affected take Augmentin before food * vomiting * diarrhoea (in children). Uncommon side effects These may affect up to 1 in 100 people rash, itching * skin itchy rash (hives) * raised * indigestion * dizziness headache.

Uncommon side effects that may show up in your blood tests: increase in some substances (enzymes) produced by the liver.

Rare side effects These may affect up to 1 in 1000 people rash, which may blister, and looks like small targets (central dark * skin spots surrounded by a paler area, with a dark ring around the edge - erythema multiforme) ? if you notice any of these symptoms contact a doctor urgently. Rare side effects that may show up in your blood tests: number of cells involved in blood clotting * low * low number of white blood cells. Frequency not known Frequency cannot be estimated from the available data. reactions (see above) * Allergic of the large intestine (see above) * Inflammation Inflammation of the protective membrane surrounding the brain * (aseptic meningitis) * Serious skin reactions: - a widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome), and a more severe form, causing extensive peeling of the skin (more than 30% of the body surface - toxic epidermal necrolysis) - widespread red skin rash with small pus-containing blisters (bullous exfoliative dermatitis) - a red, scaly rash with bumps under the skin and blisters (exanthemous pustulosis). ? Contact a doctor immediately if you get any of these symptoms. of the liver (hepatitis) * inflammation caused by increases in the blood of bilirubin (a substance * jaundice, produced in the liver) which may make your skin and whites of the eyes appear yellow of tubes in the kidney * inflammation takes longer to clot * blood * hyperactivity (in people taking high doses of Augmentin or who have kidney * convulsions problems) * black tongue which looks hairy. Side effects that may show up in your blood or urine tests: reduction in the number of white blood cells * severe number of red blood cells (haemolytic anaemia) * low * crystals in urine. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www. mhra. gov. uk/yellowcard. By reporting side effects, you can help provide more information on the safety of this medicine.

How to store this medicine

OUT OF THE SIGHT AND REACH OF CHILDREN. * KEEP not store above 25°C. * Do in a dry place. * Store not take this medicine after the expiry date shown on the carton label. * IfDoyour doctor tells you to stop taking this medicine, take any remaining medicine back to the pharmacist for safe disposal. Only keep this medicine if your doctor tells you to. If your medicine become discoloured or show any other signs of * deterioration, consult your pharmacist who will tell you what to do. Medicines should not be disposed of via wastewater or household waste. * Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

Contents of the pack and other information

What this medicine contains: Each tablet contains 500mg amoxicillin and 125 mg clavulanic acid. The other ingredients are: magnesium stearate E572, sodium starch glycollate, colloidal anhydrous silica, microcrystalline cellulose E460, titanium dioxide E172, hypromellose E464, macrogol and dimeticone. What this medicine looks like and contents of the pack Augmentin Tablets are white to off-white, oval film-coated tablets debossed with AC and a score line on one side and plain on the other. Augmentin Tablets are available in blister packs of 21 tablets. Manufacturer and Licence Holder This medicine is manufactured by SmithKline Beecham Pharmaceuticals, Worthing, West Sussex, United Kingdom and is procured from within the EU. Repackaged by the Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE. If you have any questions or are not sure about anything, ask your doctor or pharmacist. They will have additional information about this medicine and will be able to advise you.

Augmentin 625mg Tablets

Augmentin is a registered trademark of the GlaxoSmithKline Group of Companies. Revision date: 27/04/16

Blind or partially sighted? Is this leaflet hard to see or read? Phone Lexon (UK) Limited, Tel: 01527 505414 for help. Advice/medical education Antibiotics are used to treat infections caused by bacteria. They have no effect against infections caused by viruses. Sometimes an infection caused by bacteria does not respond to a course of an antibiotic. One of the commonest reasons for this to occur is because the bacteria causing the infection are resistant to the antibiotic that is being taken. This means that they can survive and even multiply despite the antibiotic. Bacteria can become resistant to antibiotics for many reasons. Using antibiotics carefully can help to reduce the chance of bacteria becoming resistant to them. When your doctor prescribes a course of an antibiotic it is intended to treat only your current illness. Paying attention to the following advice will help prevent the emergence of resistant bacteria that could stop the antibiotic working. 1. It is very important that you take the antibiotic at the right dose, at the right times and for the right number of days. Read the instructions on the label and if you do not understand anything ask your doctor or pharmacist to explain. 2. You should not take an antibiotic unless it has been prescribed specifically for you and you should use it only to treat the infection for which it was prescribed. 3. You should not take antibiotics that have been prescribed for other people even if they had an infection that was similar to yours. 4. You should not give antibiotics that were prescribed for you to other people. 5. If you have any antibiotic left over when you have taken the course as directed by your doctor you should take the remainder to a pharmacy for appropriate disposal.

Co-amoxiclav 500mg/125mg Tablets (amoxicillin / clavulanic acid) Patient Information Leaflet Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. * Keep this leaflet. You may need to read it again. * If you have any further questions, ask your doctor or pharmacist. * This medicine has been prescribed for you (or for your child). Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. * If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. Your medicine is called Co-amoxiclav 500mg/125mg Tablets but will be referred to as Co-amoxiclav throughout this Patient Information Leaflet. What is in this leaflet: 1

What Co-amoxiclav is and what it is used for

What you need to know before you take Co-amoxiclav

How to take Co-amoxiclav

Possible side effects

How to store Co-amoxiclav

Contents of the pack and other information

What Co-amoxiclav is and what it is used for

Co-amoxiclav is an antibiotic and works by killing bacteria that cause infections. It contains two different medicines called amoxicillin and clavulanic acid. Amoxicillin belongs to a group of medicines called “penicillins” that can sometimes be stopped from working (made inactive). The other active component (clavulanic acid) stops this from happening. Co-amoxiclav is used in adults and children to treat the following infections: * middle ear and sinus infections * respiratory tract infections * urinary tract infections * skin and soft tissue infections including dental infections * bone and joint infections.

Pregnancy, breast-feeding and fertility If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Driving and using machines Co-amoxiclav can have side effects and the symptoms may make you unfit to drive. Do not drive or operate machinery unless you are feeling well.

What you need to know before you take Co-amoxiclav

Do not take Co-amoxiclav: * if you are allergic to amoxicillin, clavulanic acid, penicillin or any of the other ingredients of this medicine (listed in section 6) * if you have ever had a severe allergic (hypersensitive) reaction to any other antibiotic. This can include a skin rash or swelling of the face or neck * if you have ever had liver problems or jaundice (yellowing of the skin) when taking an antibiotic. ? Do not take Co-amoxiclav if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Co-amoxiclav. Warnings and Precautions Talk to your doctor or pharmacist before taking Co-amoxiclav if you: * have glandular fever * are being treated for liver or kidney problems * are not passing water regularly. If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Co-amoxiclav. In some cases, your doctor may investigate the type of bacteria that is causing your infection. Depending on the results, you may be given a different strength of Co-amoxiclav or a different medicine. Conditions you need to look out for Co-amoxiclav can make some existing conditions worse, or cause serious side effects. These include allergic reactions, convulsions (fits) and inflammation of the large intestine. You must look out for certain symptoms while you are taking Co-amoxiclav, to reduce the risk of any problems. See ‘Conditions you need to look out for’ in Section 4. Blood and urine tests If you are having blood tests (such as red blood cell status tests or liver function tests) or urine tests (for glucose), let the doctor or nurse know that you are taking Co-amoxiclav. This is because Co-amoxiclav can affect the results of these type of tests. Other medicines and Co-amoxiclav Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines. * If you are taking allopurinol (used for gout) with Co-amoxiclav, it may be more likely that you will have an allergic skin reaction. * If you are taking probenecid (used for gout), your doctor may decide to adjust your dose of Co-amoxiclav. * If medicines to help stop blood clots (such as warfarin) are taken with Co-amoxiclav then extra blood tests may be needed. * Co-amoxiclav can affect how methotrexate (a medicine used to treat cancer or rheumatic diseases) works.

How to take Co-amoxiclav

Always take Co-amoxiclav exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. Adults and children weighing 40 kg and over The usual dose is: * 1 tablet three times a day Children weighing less than 40 kg Children aged 6 years or less should preferably be treated with Co-amoxiclav oral suspension or sachets. Ask your doctor or pharmacist for advice when giving Co-amoxiclav tablets to children weighing less than 40 kg. The tablets are not suitable for children weighing less than 25 kg. Patients with kidney and liver problems * If you have kidney problems the dose might be changed. A different strength or a different medicine may be chosen by your doctor. * If you have liver problems you may have more frequent blood tests to see how your liver is working. How to take Co-amoxiclav

* Swallow the tablets whole with a glass of water at the start of a meal or

Co-amoxiclav may affect how mycophenolate mofetil (a medicine used to prevent the rejection of transplanted organs) works.

slightly before. Tablets can be broken along the score line to make them easier to swallow. You must take both pieces of the tablet at the same time. Space the doses evenly during the day, at least 4 hours apart. Do not take 2 doses in 1 hour. Do not take Co-amoxiclav for more than 2 weeks. If you still feel unwell you should go back to see the doctor.

If you take more Co-amoxiclav than you should If you have too much Co-amoxiclav, signs might include an upset stomach (feeling sick, being sick or diarrhoea) or convulsions. Talk to your doctor as soon as possible. Take the medicine carton or bottle to show the doctor. If you forget to take Co-amoxiclav

* If you forget to take a dose, take it as soon as you remember. * You should not take the next dose too soon, but wait about 4 hours before

taking the next dose. Do not take a double dose to make up for a forgotten dose.

If you stop taking Co-amoxiclav Keep taking Co-amoxiclav until the treatment is finished, even if you feel better. You need every dose to help fight the infection. If some bacteria survive they can cause the infection to come back. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Conditions you need to look out for Allergic reactions: * skin rash * inflammation of blood vessels (vasculitis) which may be visible as red or purple raised spots on the skin, but can affect other parts of the body * fever, joint pain, swollen glands in the neck, armpit or groin * swelling, sometimes of the face or mouth (angioedema), causing difficulty in breathing * collapse. ? Contact a doctor immediately if you get any of these symptoms. Stop taking Co-amoxiclav. Inflammation of large intestine Inflammation of the large intestine, causing watery diarrhoea usually with blood and mucus, stomach pain and/or fever. ? Contact your doctor as soon as possible for advice if you get these symptoms.

Co-amoxiclav 500mg/125mg Tablets (amoxicillin / clavulanic acid) Patient Information Leaflet (continued) Very common side effects These may affect more than 1 in 10 people * diarrhoea (in adults). Common side effects These may affect up to 1 in 10 people (candida - a yeast infection of the vagina, mouth or skin folds) * thrush sick (nausea), especially when taking high doses *?feeling if affected take Augmentin before food * vomiting * diarrhoea (in children). Uncommon side effects These may affect up to 1 in 100 people rash, itching * skin itchy rash (hives) * raised * indigestion * dizziness headache.

Uncommon side effects that may show up in your blood tests: increase in some substances (enzymes) produced by the liver.

Rare side effects These may affect up to 1 in 1000 people rash, which may blister, and looks like small targets (central dark * skin spots surrounded by a paler area, with a dark ring around the edge - erythema multiforme) ? if you notice any of these symptoms contact a doctor urgently. Rare side effects that may show up in your blood tests: number of cells involved in blood clotting * low * low number of white blood cells. Frequency not known Frequency cannot be estimated from the available data. reactions (see above) * Allergic of the large intestine (see above) * Inflammation Inflammation of the protective membrane surrounding the brain * (aseptic meningitis) * Serious skin reactions: - a widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome), and a more severe form, causing extensive peeling of the skin (more than 30% of the body surface - toxic epidermal necrolysis) - widespread red skin rash with small pus-containing blisters (bullous exfoliative dermatitis) - a red, scaly rash with bumps under the skin and blisters (exanthemous pustulosis). ? Contact a doctor immediately if you get any of these symptoms. of the liver (hepatitis) * inflammation caused by increases in the blood of bilirubin (a substance * jaundice, produced in the liver) which may make your skin and whites of the eyes appear yellow of tubes in the kidney * inflammation takes longer to clot * blood * hyperactivity (in people taking high doses of Augmentin or who have kidney * convulsions problems) * black tongue which looks hairy. Side effects that may show up in your blood or urine tests: reduction in the number of white blood cells * severe number of red blood cells (haemolytic anaemia) * low * crystals in urine. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www. mhra. gov. uk/yellowcard. By reporting side effects, you can help provide more information on the safety of this medicine.

How to store this medicine

OUT OF THE SIGHT AND REACH OF CHILDREN. * KEEP not store above 25°C. * Do in a dry place. * Store not take this medicine after the expiry date shown on the carton label. * IfDoyour doctor tells you to stop taking this medicine, take any remaining medicine back to the pharmacist for safe disposal. Only keep this medicine if your doctor tells you to. If your medicine become discoloured or show any other signs of * deterioration, consult your pharmacist who will tell you what to do. Medicines should not be disposed of via wastewater or household waste. * Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

Contents of the pack and other information

What this medicine contains: Each tablet contains 500mg amoxicillin and 125 mg clavulanic acid. The other ingredients are: magnesium stearate E572, sodium starch glycollate, colloidal anhydrous silica, microcrystalline cellulose E460, titanium dioxide E172, hypromellose E464, macrogol and dimeticone. What this medicine looks like and contents of the pack Co-amoxiclav Tablets are white to off-white, oval film-coated tablets debossed with AC and a score line on one side and plain on the other. Co-amoxiclav Tablets are available in blister packs of 21 tablets. Manufacturer and Licence Holder This medicine is manufactured by SmithKline Beecham Pharmaceuticals, Worthing, West Sussex, United Kingdom and is procured from within the EU. Repackaged by the Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE. If you have any questions or are not sure about anything, ask your doctor or pharmacist. They will have additional information about this medicine and will be able to advise you.

Co-amoxiclav 625mg Tablets

Co-amoxiclav is a registered trademark of the GlaxoSmithKline Group of Companies. Revision date: 27/04/16

Blind or partially sighted? Is this leaflet hard to see or read? Phone Lexon (UK) Limited, Tel: 01527 505414 for help. Advice/medical education Antibiotics are used to treat infections caused by bacteria. They have no effect against infections caused by viruses. Sometimes an infection caused by bacteria does not respond to a course of an antibiotic. One of the commonest reasons for this to occur is because the bacteria causing the infection are resistant to the antibiotic that is being taken. This means that they can survive and even multiply despite the antibiotic. Bacteria can become resistant to antibiotics for many reasons. Using antibiotics carefully can help to reduce the chance of bacteria becoming resistant to them. When your doctor prescribes a course of an antibiotic it is intended to treat only your current illness. Paying attention to the following advice will help prevent the emergence of resistant bacteria that could stop the antibiotic working. 1. It is very important that you take the antibiotic at the right dose, at the right times and for the right number of days. Read the instructions on the label and if you do not understand anything ask your doctor or pharmacist to explain. 2. You should not take an antibiotic unless it has been prescribed specifically for you and you should use it only to treat the infection for which it was prescribed. 3. You should not take antibiotics that have been prescribed for other people even if they had an infection that was similar to yours. 4. You should not give antibiotics that were prescribed for you to other people. 5. If you have any antibiotic left over when you have taken the course as directed by your doctor you should take the remainder to a pharmacy for appropriate disposal.

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



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Camcolit (Lithium Carbonate) Report For Patients Like You, Camcolit

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What is lithium?

Lithium affects the flow of sodium through nerve and muscle cells in the body. Sodium affects excitation or mania.

Lithium is used to treat the manic episodes of manic depression. Manic symptoms include hyperactivity, rushed speech, poor judgment, reduced need for sleep, aggression, and anger. Lithium also helps to prevent or lessen the intensity of manic episodes.

Lithium may also be used for other purposes not listed in this medication guide.

Precautions

Do not use this medication if you are allergic to lithium.

Before taking lithium, tell your doctor if you are allergic to any drugs, or if you have:

heart disease;

kidney disease;

underactive thyroid;

a severe or debilitating medical condition; or

if you are dehydrated or have low levels of sodium in your blood (hyponatremia).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take lithium.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use lithium without your doctor’s consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.

Lithium can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the effects of this medication.

Do not give lithium to a child younger than 12 years old.

Lithium can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor’s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Do not change the amount of salt that you consume in your diet. Changing your intake of salt could alter the amount of lithium in your blood.

Instructions

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, diarrhea, drowsiness, muscle weakness, tremor, lack of coordination, blurred vision, or ringing in your ears.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking lithium and call your doctor at once if you have any of these serious side effects:

extreme thirst, urinating more or less than usual;

weakness, fever, feeling restless or confused, eye pain and vision problems;

restless muscle movements in your eyes, tongue, jaw, or neck;

pain, cold feeling, or discoloration in your fingers or toes;

feeling light-headed, fainting, slow heart rate;

hallucinations, seizure (blackout or convulsions);

fever with muscle stiffness, sweating, fast or uneven heartbeats; or

early signs of lithium toxicity, such as nausea, vomiting, diarrhea, drowsiness, muscle weakness, tremor, lack of coordination, blurred vision, or ringing in your ears.

Less serious side effects may include:

mild tremor of the hands;

weakness, lack of coordination;

mild nausea, vomiting, loss of appetite, stomach pain or upset;

thinning or drying of the hair; or

itching skin.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Interactions

Before taking lithium, tell your doctor if you are taking any other medications, especially any of the following:

acetazolamide (Diamox);

aminophylline (Truphylline) or theophylline (Elixophyllin, Respbid, Theo-Bid, Theo-Dur, Uniphyl);

sodium bicarbonate (Alka-Seltzer, Bicitra, Polycitra, or baking soda home remedy antacid);

carbamazepine (Carbatrol, Tegretol);

fluoxetine (Prozac);

metronidazole (Flagyl);

potassium iodide thyroid medication (Pima);

an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik);

a calcium channel blocker such as diltiazem (Tiazac, Cartia, Cardizem) or verapamil (Calan, Covera, Isoptin, Verelan);

a diuretic (water pill) such as amiloride (Midamor, Moduretic), bumetanide (Bumex), chlorthalidone (Hygroton, Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Vasoretic, Zestoretic), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), spironolactone (Aldactazide, Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), torsemide (Demadex), and others;

medicines to treat psychiatric disorders, such as haloperidol (Haldol), aripiprazole (Abilify), chlorpromazine (Thorazine), clozapine (Clozaril, Fazaclo), olanzapine (Zyprexa), quetiapine (Seroquel), pimozide (Orap), risperidone (Risperdal), or ziprasidone (Geodon); or

celecoxib (Celebrex) or an NSAID (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.

This list is not complete and there may be other drugs that can interact with lithium. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

Eskalith, Eskalith-CR, Lithobid, Lithonate, Lithotabs, and lithium

Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

Last updated: September 19, 2016

What is the most important information I should know about lithium?

Do not use this medication without telling your doctor if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Call your doctor at once if you have any early signs of lithium toxicity, such as nausea, vomiting, diarrhea, drowsiness, muscle weakness, tremor, lack of coordination, blurred vision, or ringing in your ears.

Do not crush, chew, or break an extended-release tablet. Swallow the pill whole.

Drink extra fluids to keep from getting dehydrated while you are taking lithium. Tell your doctor if you have been sweating excessively, or if you are sick with fever, vomiting, or diarrhea.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor’s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Lithium can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Warning

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed



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Tretinoin Medlineplus Drug Information, Tretinoone

Tretinoin

Tretinoin may cause severe side effects. Tretinoin should be given only under the supervision of a doctor who has experience in treating people who have leukemia (cancer of the white blood cells) and in a hospital where patients can be monitored for severe side effects and treated if these side effects occur.

Tretinoin may cause a serious or life-threatening group of symptoms called retinoic acid-APL(RA-APL) syndrome. Your doctor will monitor you carefully to see whether you are developing this syndrome. If you experience any of the following symptoms, call your doctor immediately: fever; weight gain; swelling of the arms, hands, feet, ankles, or lower legs; shortness of breath; labored breathing; wheezing; chest pain; or cough. At the first sign that you are developing RA-APL syndrome, your doctor will prescribe one or more medications to treat the syndrome.

Tretinoin may cause a rapid increase in the number of white blood cells in the body. This is associated with a higher risk of life-threatening side effects. If you have a very high number of white blood cells before you begin tretinoin treatment, or if you have an increase in the number of white blood cells during your treatment with tretinoin, expecially if you experience any of the symptoms of RA-APL syndrome, your doctor may prescribe one or more medications to treat or prevent the increase in white blood cells.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to tretinoin.

Talk to your doctor about the risk(s) of taking tretinoin.

For female patients:

Tretinoin must not be taken by patients who are pregnant or who may become pregnant. There is a high risk that tretinoin will cause the baby to be born with birth defects (physical problems that are present at birth).

If you can become pregnant, you will need to avoid pregnancy during your treatment with tretinoin. You must use two acceptable forms of birth control during your treatment and for 1 month after your treatment, even if you have infertility (difficulty becoming pregnant) or have experienced menopause ('change of life'; end of monthly menstrual periods). You must use these two forms of birth control at all times unless you can promise that you will not have any sexual contact with a male for 1 month after your treatment. Your doctor will tell you which forms of birth control are acceptable, and will give you full information about birth control.

If you plan to use oral contraceptives (birth control pills) while taking tretinoin, tell your doctor the name of the pill you will use. Microdosed progestin ('minipill') oral contraceptives (Ovrette, Micronor, Nor-D) may not be an effective form of birth control for people who are taking tretinoin.

You must have a negative pregnancy test within 1 week before you begin to take tretinoin. You will also need to be tested for pregnancy in a laboratory each month during your treatment. Tell your doctor immediately if you think you might be pregnant at any time during your treatment with tretinoin.

Why is this medication prescribed?

Tretinoin is used to treat acute promyelocytic leukemia (APL; a type of cancer in which there are too many immature blood cells in the blood and bone marrow) in people who have not been helped by other types of chemotherapy or whose condition has improved but then worsened following treatment with other types of chemotherapy. Tretinoin is used to produce remission (a decrease or disappearance of signs and symptoms of cancer) of APL, but other medications must be used after treatment with tretinoin to prevent the cancer from returning. Tretinoin is in a class of medications called retinoids. It works by slowing or stopping the growth of cancer cells by causing immature blood cells to develop into normal blood cells.

How should this medicine be used?

Tretinoin comes as a capsule to take by mouth. It is usually taken twice a day for up to 90 days. Take tretinoin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tretinoin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take tretinoin even if you feel well. Do not stop taking tretinoin without talking to your doctor.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking tretinoin,

tell your doctor and pharmacist if you are allergic to tretinoin, other retinoids such as acitretin (Soriatane), etretinate (Tegison), bexarotene, or isotretinoin (Accutane, Claravis, Sotret), any other medications, parabens (a preservative), or any of the other ingredients in tretinoin capsules. Ask your doctor or pharmacist for a list of the ingredients.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminocaproic acid (Amicar); certain calcium channel blockers such as diltiazem (Cardizem, Dilacor, Tiazac, others) and verapamil (Calan, Covera, Isoptin, Verelan); cimetidine (Tagamet); cyclosporine (Sandimmune, Gengraf, Neoral); erythromycin (E. E.S. Erythrocin, E-Mycin); hydroxyurea (Droxia); ketoconazole (Nizoral); pentobarbital; phenobarbital; rifampin (Rifadin, Rimactane);oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); tetracycline antibiotics such as demeclocycline (Declomycin), doxycycline (Monodox, Vibramycin, others), minocycline (Minocin), oxytetracycline (Terramycin), and tetracycline (Sumycin, Tetrex, others); tranexamic acid (Cyklokapron); and vitamin A. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with tretinoin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

tell your doctor if you have or have ever had increased amounts of cholesterol (a fat-like substance) and other fatty substances in the blood, or liver or heart disease.

tell your doctor if you are breast-feeding.

if you will be having surgery, including dental surgery, tell your doctor or dentist that you are taking tretinoin.

you should know that tretinoin may cause dizziness or severe headache. Do not drive a car or operate machinery until you know how this medication affects you.

What special dietary instructions should I follow?

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Tretinoin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

weakness

extreme tiredness

shivering

pain

earache

feeling of fullness in the ears

dry skin

rash

hair loss

constipation

diarrhea

stomach pain

heartburn

loss of appetite

weight loss

bone pain

dizziness

numbness, burning, or tingling in the hands or feet

nervousness

depression

difficulty falling asleep or staying asleep

confusion

agitation

hallucinating (seeing things or hearing voices that do not exist)

difficulty urinating

flushing

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

headache

nausea

vomiting

blurred or double vision, or other vision problems

unusual bruising or bleeding

vomit that is bloody or looks like coffee grounds

bright red or black and tarry stools

irregular heartbeat

hearing loss

bleeding

infections

Tretinoin may increase the levels of cholesterol and other fats in your blood and may stop your liver from working normally. Your doctor will monitor you carefully to see whether you are experiencing either of these side effects.

Tretinoin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

headache

flushing

red, cracked, and sore lips

stomach pain

dizziness

loss of coordination

What other information should I know?

Do not let anyone else take your medication. Ask your pharmacist if you have any questions about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names



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Armanaks, Armanaks

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Naproxen (Naprosyn)

is a medicine that is widely prescribed in the treatment of pain and inflammation that can be caused by a variety of medical conditions:

Ankylosing Spondylitis

Aseptic Necrosis

Back Pain

Bursitis

Chronic Myofascial Pain

Costochondritis

Diffuse Idiopathic Skeletal Hyperostosis

Dysautonomia

Fever

Frozen Shoulder

Gout – Acute

Headache

Juvenile Rheumatoid Arthritis

Muscle Pain

Osteoarthritis

Pain

Period Pain

Radiculopathy

Rheumatoid Arthritis

Sciatica

Spondylolisthesis

Tendonitis

Transverse Myelitis

It is also used for the treatment of primary dysmenorrhea.

Brand Names : Adco-Naproxen, Adin N, Aflamax, Aflaxil, Aksen Fort, ALACETAN NNA, Aleve, Aleve, Aleve-D Sinus & Cold (Naproxen and Pseudoephedrine), Alevetabs, Alidase, Alidase, Alpoxen, Alpron, Anaflex, Anaflex SR, Analgen, Anapran, Anapran Neo, Anaprox, Anaprox DS, Anex, Annoxen-S, A-Nox, Antalgin, Ao Pu Li, Apain, Apo-Napro, Apo-Napro-Na, Apo-Naproxen, Apralgin Forte, Apraljin, Apranax, Apranax, Apraxin, Aprodent, Aprol, Apromed, Apronax, Apronax, Apron-F, Aprowell, Aproxen, Aproxil, Armanaks, Artagen, Arthopan (Naproxen and Pantoprazole), Arthrox, Aspen Naproxen, Assonax, Atac, Aterpin (Naproxen and Paracetamol), Bai Tong, Beckanflam, Bei Li, Bifardol (Naproxen and Paracetamol), Bloxen, Bonmin, Bonyl, Boots Period Pain Relief, Boots Pharmacy Period Pain Relief, Brax (Naproxen and Paracetamol), Bremol (Naproxen and Paracetamol), Brixonax, Brunadol (Naproxen and Paracetamol), Brunadol (Naproxen and Paracetamol), Bruproxen, Bumaflex N, Chemists’ Own Period Pain Tablets, Colfem Forte (Naproxen and Scopolamine), Congex, Cudeprox, Dafloxen, Dafloxen F (Naproxen and Paracetamol), Debril, Deflamox Plus (Naproxen and Paracetamol), Deproxen, Desinflam, Deucoval, Deucoval Forte, Diproxen, Diproxen CR, Dolo Apranax (Naproxen and Paracetamol), Dolofleximax, Dolomes, Dolormin mit Naproxen, Dolotandax (Naproxen and Paracetamol (veterinary use)), Doprox, Dozin, Dropsen, Dysmenalgit, EC-Naprosyn, Emox, Emoxen, Equiproxen (veterinary use), Eurogesic, Eurogesic, Eurogesic Forte, Exvile, Fabralgina, Febrax (Naproxen and Paracetamol), Feminax Ultra, Femynass, Flanax, Flogotone, Fluconazinn, Gao Di (Naproxen and Pseudoephedrine), Gen-Naproxen EC, Gerinap, Gynestrel, Honlow, Hui Ke, Improstan, Inflamax, Inza, Iraxen, Jia Dan, Jie Jie, Jinkangpuli, Kapnax, Karoksen, Laser, Lexinax, Licorax, Liotondol Action, Lumbal Lafrancol (Naproxen and Caffeine), Lundiran, Mafidol Compuesto (Naproxen and Paracetamol), Mai Er, Maxiflam, Mednap, Melgar, Messelxen, Miranax, Mobilat, Momendol, Momendol, Momendol (Naproxen and Sulodexide), Monarit, Monochroton, Movibon, Mylan Naproxen, Na Pu Xing, Nafar, Nafasol, Nafxen, Naixan, Nalgesin, Nalgesin, Nalgesin Forte, Nalgesin Forte, Nalgesin S, Nalgesin S, Naloxen, Napec, Napflam, Napmel, Naponal, Naposin, Napoton, Napoxen, Napradol, Napratec (Naproxen and Misoprostol), Napreben, Naprelan, Napren-E, Naprind, Naprius, Napro, Napro Itedal, Napro-A, Naprobene, Naprocet, Naprocop Compuesto (Naproxen and Paracetamol), Naprodel, Naprodev, Naprodom (Naproxen and Domperidone), Naprofidex, Naproflam, Naproflex, Naprogen, Naprogesic, Naprogesic Forte, Naproksen, Naproksens, Napromed, Naprometin, Naprontag, Napro-Pac (Naproxen and Lansoprazole), Napropain, Naprophar, Naprophar Duo (Naproxen and Paracetamol), Naprorex, Naprosian, Naproson, Naprossene Eg, Naprosyn, Naprosyn, Naprosyn CR, Naprosyn EC, Naprosyn Entero, Naprosyn SR, Naprosyne, Naproval, Naproven, Naprovite, Naprox, Naproxen, Naproxen – 1 A Pharma, Naproxen – Shyndec Pharm, 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CH. Naproxeno Sodico Mintlab, Naproxeno Sodico MK, Naproxeno Sodico Nifa, Naproxen-ratiopharm, Naproxfilm, Naproxin, Naproxol, Naproxpharma, Naprozen, Naprux, Naprux Gesic, Napryn, Napsen, Napsod, Napsyn, Napton, Napton, Napton SR, Napusin, Naputon, Narocin, Natoxen, Natrax, Naxdom (Naproxen and Domperidone), Naxen, Naxin, Naxo, Naxodol (Naproxen and Carisoprodol), Naxyn, Neo Eblimon, Neoprox, Neoproxen, Neuralgesic (Naproxen and Paracetamol), Neuralprona, Nitens, Noflam, Nomax Dol (Naproxen and Paracetamol), Nomaxen, Nopain, Nopain, Nopain DS, Nopraxin, Novo-Naprox, Novo-Naprox Sodium, Noxen, Noyan, Nu-Naprox, Nuprafen, Nupralgin, Nurolasts, Odontogesic, Onexol, Onexol Duo (Naproxen and Paracetamol), Opraks, Pabi-Naproxen, Painflex, Pairox, Period Pain Reliever, Pharex Naproxen, PMS-Naproxen, PMS-Naproxen EC, Point, Polyxen, Ponstan RD, Prexan, Priaxen, Promaxx Farma, Promizem, Pronaxen, Proxagol, Proxalin-Plus (Naproxen and Paracetamol), Proxen, Proxen S, Proxen SR, Proxidol, Pu Sen Ou Ke (Naproxen and Pseudoephedrine), Qi Gu Ke, Quilnax Duo (Naproxen and Paracetamol), Ramoksen, Releve, Relokap Fort, Repro, Reuxen, Riproxen, Safrosyn, Sanaprox, Sanomed, Seladin, Servinaprox, Shi Luo Te, Sindolan, Sinton, Skelan, Soden, Sonafalm, Sonap, Soproxen, Sumigran (Naproxen and Sumatriptan), Sunprox, Supofebril, Sutolin, Synalgo, Synax, Synflex, Tai Ze, Tarproxen, Teva-Naproxen, Teva-Naproxen Sodium, Teva-Naproxen Sodium DS, Teva-Naproxen-EC, Ticoflex, Togal Naproxen, Treximet (Naproxen and Sumatriptan), Triox, Tundra, Uninapro, U-Ritis, Vimovo (Naproxen and Esomeprazole), Winpron, Xenapro, Xenar-CR, Xenifar, Xenodol, Xi Tai Meng (Naproxen and Codeine), Xpro, YuanQi.

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Constilax, Constilax

Product Description Common use Noroxin is quinolone antibiotic used for treatment of urinary tract such as pyelonephritis, cystitis, urethritis), genitals (prostatitis, cervicitis, endometritis), gastrointestinal tract (salmonellosis, shigellosis), uncomplicated gonorrhea. Mechanism of its action consists in inhibition of DNA gyrase leading to destabilization of the bacterial DNA and death of the susceptible bacteria. Noroxin is active against Staphylococcus spp. (including Staphylococcus aureus), Neisseria spp. E. coli, Citrobacter spp. Klebsiella spp. Proteus spp. Salmonella spp. Enterobacter spp. Hafnia, Shigella spp. Mycobacterium tuberculosis, Vibrio cholerae, Haemophilus influenzae, Chlamydia spp. Mycoplasma spp. and some others. Medication is active for 12 hours.

Dosage and directions To treat infections of urinary tract, take 400 mg of Noroxin two times a day during 7-10 days, to treat non-complicated cystitis treatment continues 3-7 days, and in patients with recurrent chronic infection of urinary tract it is up to 12 weeks. For prostatitis the recommended daily dose is 800 mg, divided into 2 doses, for four weeks. Usual single recommended dose to treat gonorrhea is 800 milligrams for 1 day. The maximal daily dose is 800 milligrams. Take with a full glass of water two hours after a meal or one hour before it. Drink plenty of water while taking Noroxin to avoid formation of needle-shaped crystals in your urine. The elderly and people with kidney problems may need to use a reduced dosage or have their kidney function monitored. Take exactly as prescribed by your doctor. Do not start or stop treatment without your doctor's permission.

Precautions In elderly and patients with kidney impairment, kidney function monitoring is required on a regular basis. This medication may cause photosensibilization, avoid direct sun rays during treatment. Limit consummation of alcoholic beverages as they may worsen such side effects as dizziness, drowsiness and others which may affect your ability to operate machinery and driving.

Contraindications This medication cannot be administered in patients with hypersensitivity to Noroxin, pregnant and breastfeeding women, children under 18 y. o. individuals with glucose-6-phosphate dehydrogenase deficiency. Caution is required when Noroxin is administered in individuals with cerebral arteriosclerosis, cerebrovascular dysfunctions, epilepsy, epileptic syndrome, Myasthenia gravis, kidney or liver failure.

Possible side effect The most common side effects include: weakness, headache, drowsiness, dizziness, nausea, stomach upset. Rare but serious side effects are: tremor and sun sensitivity, seizures, mental/mood changes, sore throat/fever, vision changes, hearing loss, change in amount or appearance of urine, jaundice, fainting, changes in heartbeat, easy bruising or bleeding, numbness or tingling of extremities. Tendon damage and weakening of muscles is rare but possible. Stop exercising and claim prompt medical attention if you experience pain in your joint or tendon. In case of pseudomembranous colitis (persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool) which may develop even a few weeks after the treatment was discontinued, do not use anti-diarrhea products or narcotic pain medications. Tell your doctor immediately about your condition. Prolonged or repeated used of Noroxin may cause oral thrush or a new vaginal yeast infection with such symptoms as: white patches in the mouth, a change in vaginal discharge. Inform your doctor immediately if you experience allergic reaction (severe dizziness, rash, itching, swelling, trouble breathing).

Drug interaction Theophylline dose should be decreased while on Noroxin. Noroxin increases the blood concentration of indirect anticoagulants, cyclosporine, decreases effects of nitrofurans. Antacids which contain ions of Al and Mg, medications which contain Fe, Zn2+, sucralfate should be taken at least with four hour interval with Noroxin. Concomitant intake with the medicines decreasing epileptic threshold may lead to epileptic attacks. Dangerous sudden drop in blood pressure or changes in heart rhythm are possible when Noroxin is concomitantly used with the drugs for blood pressure or affecting the heart rhythm. Inform your doctor about all prescribed and over-the-counter medications and herbal products you are taking.

Missed dose If you miss a dose, take it as soon as you remember unless it is almost time of your next dose. If it is near the time of the next dose, skip the missed dose and return dosing schedule. Do not double the dose to make up the missed dose.

Overdose Symptoms of overdose include: dizziness, nausea, vomiting, drowsiness, "cold" sweating, puffy face without major changes in hemodynamic indices.

Storage Store at room temperature in a tight container, away from moisture and humidity.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.



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Glucosamine - Side Effects, Dosage, Interactions, Glucosamine

Glucosamine

Glucosamine is a dietary supplement that some people take to support bone and joint health.

Some studies suggest the supplement may relieve pain caused by osteoarthritis and wear and tear on the joints.

The body naturally produces glucosamine, but the glucosamine found in supplements comes from shellfish or is synthesized in a laboratory.

Glucosamine is available without a prescription (over-the-counter, or OTC).

Glucosamine and Chondroitin

Glucosamine can be taken as a single supplement, but it's most commonly combined with other supplements, especially chondroitin.

Chondroitin is a protein that comes from shark or cow cartilage.

Glucosamine and Dogs

Some studies suggest that glucosamine and chondroitin might provide some pain relief in animals, including dogs, cats, and horses.

In particular, glucosamine and chondroitin together might be helpful in relieving pain in dogs and cats plagued by worn cartilage in the hip joint.

Talk with your veterinarian about glucosamine for dogs or other animals before you give them the supplement.

Glucosamine Warnings

Glucosamine can thin the blood, so you might want to ask your doctor or pharmacist before taking blood thinners, such as warfarin (Coumadin and Jantoven), enoxaparin (Lovenox ), apixaban (Eliquis ), rivaroxaban (Xarelto ), or dabigatran (Pradaxa ).

People with diabetes should know that glucosamine might raise blood sugar, since glucose is part of glucosamine's structure.

Taking glucosamine with an herbal supplement that contains skullcap increases the risk of liver damage.

If you want to take glucosamine, discontinue using any supplement that contains skullcap.

If you're allergic to shellfish, you still may be able to use glucosamine made from shellfish since shells themselves do not contain the protein that causes an allergic reaction.

Pregnancy and Glucosamine

To date, there aren't any studies showing how glucosamine affects unborn babies or infants whose mothers take glucosamine while breastfeeding.

Talk to your doctor before taking glucosamine if you're pregnant, might become pregnant, or are breastfeeding.

Tell your doctor all the medications you take.

This includes prescription and over-the-counter (OTC) medications, vitamins and other dietary supplements (nutritional shakes, protein powders, etc.), herbal remedies, and any illegal and recreational drugs.

Ask your doctor about whether glucosamine is safe for you if you're taking any of the following:

Non-steroidal anti-inflammatory drugs (NSAIDs ), such as ibuprofen (Relafen, Motrin, Advil) and naproxen (Aleve, Anaprox, Naprosyn)

Drugs that stop platelets from sticking together, such as clopidogrel (Plavix) and prasugrel (Effient)

Blood thinners, such as warfarin (Coumadin. Jantoven), heparin, apixaban (Eliquis ), rivaroxaban (Xarelto ), and fondaparinux (Arixtra)

Medications for depression like citalopram (Celexa) and venlafaxine (Effexor)

Cancer chemotherapy drugs, such as etoposide (Etopophos) and doxorubicin (Adriamycin)

Diabetes medications, such as pioglitazone (Actos), rosiglitazone (Avandia), and insulin

Glucosamine and Alcohol

Some data suggest that glucosamine may interact with alcohol, so avoid drinking alcohol while taking the supplement.

Glucosamine and Grapefruit Juice

The liver breaks down glucosamine, but scientists aren't sure whether grapefruit juice interferes with that process.

To be safe, it's best not to take glucosamine with grapefruit or the juice.

Glucosamine Dosage

You can buy glucosamine by itself in varying amounts per tablet.

You can also purchase glucosamine pills that also contain chondroitin or another vitamin, such as vitamin D3 .

Since the effective dose varies according to the reason you're taking it, talk to your physician about how much you should take.

The usual dose of glucosamine is 500 mg, three times a day for osteoarthritis and temporomandibular joint dysfunction (TMJ).

Glucosamine Overdose

If you think you might have overdosed on glucosamine, call your poison control center or emergency room right away.

You can contact a poison control center at (800) 222-1222.

Missed Dose of Glucosamine

If you miss a dose of glucosamine, take it as soon as you remember.

If it's almost time for the next dose, skip the missed dose and take your next dose at the regular time.

Don't take two doses of the supplement at the same time.

Glucosamine FAQ

Q: Is it okay to take chondroitin and/or glucosamine with a multivitamin?

A: Yes. There are no contraindications of taking chondroitin and or glucosamine with a multivitamin. If you are diabetic, there is some evidence that taking the two together may alter blood sugar levels.

Q: I was told that glucosamine and chondroitin was good for knee joints. Is it safe for type 2 diabetics (not on insulin)?

A: In theory, glucosamine may decrease insulin production or increase the body's resistance to the effects of insulin. Both of these actions could result in high blood sugar. However, studies generally show that this is probably not a problem for most people. Consult with your physician before starting this supplement and it might be a good idea to check your blood sugar more often when starting or stopping glucosamine, just to be safe. Lori Poulin, PharmD

Q: I'm 64 and take glucosamine daily. Could that be causing occasional slight stomach pains, or should I look for another cause?

A: Common side effects of glucosamine sulfate include nausea, vomiting, indigestion, diarrhea, or constipation. Taking glucosamine with meals may help alleviate some of these side effects. Consult your health care provider for proper evaluation of stomach pain or upset, particularly if it continues during a rest from the drug. Sarah Lewis, PharmD

Q: I have arthritis and am considering taking glucosamine. Does it really help?

A: Glucosamine is an over-the-counter (OTC) dietary supplement used to alleviate the symptoms of arthritis. It is not a FDA-approved medication; therefore, it is has not undergone the rigorous testing and approval that the FDA performs on FDA-approved products. In addition, the effectiveness and safety of the medication has not been evaluated by the FDA. There is an interesting article on Everyday Health addressing the issue on how well glucosamine works at http://www. everydayhealth. com/publicsite/index. aspx? puid=5431AD93-BECF-4A51-8BD4-29C925576A8A&id=620078. The article quotes Dr. Steven Vlad saying "There is still a lot of uncertainty about glucosamine." Dr. Vlad reviewed studies on glucosamine and feels that glucosamine hydrochloride doesn't work. Glucosamine sulfate showed wide variation on how well it works. Some physicians support the use of glucosamine while others do not. It appears that more studies need to be performed to fully realize what benefits this product provides. Please speak to your health care provider for further information about glucosamine and if it would be beneficial to you. You may also find helpful information on glucosamine at http://www. everydayhealth. com/drugs/glucosamine. Jennyfer Marsico RPh

Q: Do products like Joint Juice and glucosamine really work? If yes, what is the best form for digestion?

A: Although the studies on glucosamine and chondroitin are inconclusive, I have several patients tell me that they can tell the difference when they stop using them after they had been for several months. I think that in their large tablet form that there is an argument for absorption. Products such as "Joint Juice" market their product with the promise that their product will be more rapidly absorbed and a larger amount of the active substance will be absorbed. However, research has told us that it takes several weeks to a month before any noticeable improvement is recognized, so "rapid" absorption may not necessarily be pertinent. Furthermore, if their claims are true, keep in mind that putting drugs in liquid form typically lowers the shelf life of the substance significantly. Currently, in the United States, glucosamine and chondroitin are approved as dietary supplements only and are not approved for any medicinal use. Here is a link to a forum that addresses your very question: http://www. everydayhealth. com/forums/arthritis/topic/glucosamine-and-condroitin-liquid. Matt Curley, PharmD

Q: I have been taking glucosamine for joint pain and to keep joints healthy. I was told it is just "a sugar" pill. Is glucosamine good for joints or just a sugar pill?

A: There is much controversy surrounding glucosamine and its effectiveness. Glucosamine is classified as a dietary supplement. Many supplements such as glucosamine are not FDA-approved medications. This means that the extensive testing that is performed on FDA approved products including but not limited to safety, side effects, drug interactions, disease state issues, etc. has not been performed on supplements that are not FDA-approved. With that being said, claims have been made that glucosamine helps alleviate symptoms of arthritis. Glucosamine may be involved with production of cartilage. As with any supplement, the recommendation is to talk to your health care provider to determine if glucosamine is an appropriate treatment for you. Click here for an article on Everyday Health that discusses the struggle of studies to gauge the worth of glucosamine. The article states that there is still a lot of uncertainty regarding glucosamine. As always, talk with your health care provider regarding questions you have about over the counter supplements. Jen Marsico, RPh

Q: After taking glucosamine with sulfate I developed muscle weakness in my arms and legs. Why is this happening to me? I stopped taking it, but now still have joint pain. What can I take?

A: Glucosamine is registered with the Food and Drug Administration (FDA) as a food supplement and it is not meant to cure, treat or prevent any disease. They obtain glucosamine from shellfish, so I'm guessing that you may have a shellfish sensitivity. As far as what else you can take, please contact your provider for the best selection for you, I do not have your chart in front of me and I don't know the severity of your joint pain. Most people typically start with Tylenol for arthritis. Matt Curley, PharmD

Q: Does Glucosamine cause fluid retention?

A: Glucosamine is a compound that is found naturally in the body. Glucosamine is needed to produce glycosaminoglycan, a molecule used in the formation and repair of cartilage and other body tissues. People use this supplement to help with arthritis, especially in knees, to help repair damaged cartilage in the joints. For information on this medication, click on this link: http://www. everydayhealth. com/drugs/glucosamine The most common side effects of glucosamine are stomach upset, drowsiness, headache, insomnia, heartburn, constipation or diarrhea and nausea. Fluid retention is not mentioned as a side effect of this supplement. If you are experiencing any type of fluid retention, you should consult with your physician to be sure other medications or underlying medical conditions are not causing the problem. Lori Mendoza, PharmD Poulin, PharmD

Q: How long will it take before I should see some relief from knee pain from taking glucosamine chondroitin? Also are there any pain medications that aren't hard on the kidneys, as I am diabetic with some kidney damage?

A: Glucosamine is naturally found in healthy cartilage. According to the National Institute of Health, there is good evidence to support the use of glucosamine sulfate in the treatment of mild-to-moderate knee osteoarthritis. It is believed that the sulfate form provides clinical benefit in the synovial fluid by strengthening cartilage and aiding glycosaminoglycan synthesis. Currently, other forms of glucosamine (such as the hydrochloride) do not have the scientific evidence like the sulfate form does. Most studies that showed an effect of glucosamine sulfate on arthritis were conducted over a period of 30 to 90 days. Acetaminophen is generally recommended over aspirin and the nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen or naproxen) for occasional use in patients with kidney disease. It is important to follow the labeled instructions for dosing. Acetaminophen in excessive doses or in combination with alcohol can cause liver problems. For longer-term use, you should speak to your doctor about what the best choice is for you. Michelle McDermott, PharmD

Q: I take lovastatin, lisinopril, atenolol, and Maxzide. Could I also take a joint medication such as glucosamine? Would it cause any interference with my prescriptions?

A: There aren't drug interactions listed between glucosamine and the other medications you're taking. However, it's important to understand that products sold as dietary or nutritional supplements (such as glucosamine) don't undergo the same detailed testing in the United States that prescription drug products do to show that they're safe and effective. Most supplements haven't been tested to find out if they interact with medicines, foods, or other herbs and supplements. It's also important for your doctor to be aware of all supplements you take, because of the risk of interactinos. So be sure to check with your doctor about taking glucosamine. Michelle McDermott, PharmD

Q: What is the best product to help build cartilage between joints?

A: The combination of glucosamine and chondroitin is often used to help maintain healthy joints. Chondroitin is a naturally occurring substance made up of sugar chains. It is believed to help the body maintain fluid and flexibility in the joints. Glucosamine is a sugar protein that is believed to help develop and renew cartilage. Cartilage is the hard connective tissue located mainly on bones near joints in the body. Glucosamine may help keep cartilage lubricated to improve joint movement and flexibility. The combination is marketed as a nutritional supplement for people with osteoarthritis or other inflammatory joint disorders. Nutritional and herbal supplements are not regulated by the U. S. Food and Drug Administration (FDA) in the same way that prescription and over-the-counter medications are. Because supplements are not strictly regulated by the FDA, these products are not required to be tested for effectiveness, purity, or safety. So, their manufacturers aren

Q: Is there a prescription drug name for glucosamine?

A: Glucosamine, which is produced naturally in the body, plays a key role in building cartilage, the tough connective tissue that cushions the joints. A number of scientific studies suggest that glucosamine may be an effective treatment for osteoarthritis (OA). Osteoarthritis is a type of arthritis that occurs when cartilage breaks down and is lost, either due to injury or to normal wear and tear. Studies have not shown conclusively that glucosamine helps repair or grow new cartilage, or stops cartilage from being further damaged. Glucosamine is available in oral dietary supplements as glucosamine sulfate, glucosamine hydrochloride, and n-acetyl glucosamine. These products may come in tablet, capsule, and powder forms. It is often combined with chondroitin and sometimes manganese as well. Glucosamine is classified as a dietary supplement in the US. Because herbs and supplements are not strictly regulated by the U. S. Food and Drug Administration, these products are not required to be tested for effectiveness, purity, or safety. In general, dietary supplements should only be taken under the supervision of your health care provider. For more specific information, consult with your pharmacist about the potential for drug interactions based on your specific condition and current medications, particularly before taking any action. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Shereen A. Gharbia, PharmD

Q: I have just started taking glucosamine and chondroitin without consulting a physician. I have diabetes (which is totally under control because of my exercise regimen), but should I check with my doctor about this?

A: It is highly recommended that patients inform their provider any time a new supplement or over-the-counter medication has been or will be taken. Glucosamine is a food supplement in this country and it is not meant to treat, cure or prevent any disease or specific ailment. With that said, there are several people that feel that glucosamine is very effective treatment for their arthritis. For diabetics, it has been shown that it can cause blood sugar to fluctuate and can slightly increase cholesterol levels. I would recommend that anyone that has diabetes closely watch their glucose levels and record them. Based on the results after a week, I recommend discussing continuing glucosamine with the provider if he or she feels that the "treatment" is warranted. Keep in mind it may take several weeks to realize a benefit from the use of the glucosamine. Matt Curley, PharmD

Q: I take glucosamine, chondroitin, and Lutera (birth control). Is this a problem?

A: Glucosamine and chondroitin is considered a dietary supplement. Many supplements such as glucosamine and chondroitin are not Food and Drug Administration (FDA) approved medications. This means that the extensive testing that is performed on FDA-approved products including but not limited to safety, side effects, drug interactions, disease state issues, etc. has not been performed on supplements that are not FDA approved. With that being said, a drug interaction report was performed by Lexi-Comp on your Lutera and glucosamine chondroitin and no interactions were detected. As always, talk with your health care provider regarding questions you have about your medications. Jen Marsico, RPh

Q: What is glucosamine for?

A: Glucosamine and chondroitin are compounds derived from cartilage and they are available as dietary supplements. According to the National Institutes of Health, results of scientific studies support the use of glucosamine in the treatment of osteoarthritis, especially when the arthritis is present in the knee. Scientists believe that the supplements strengthen cartilage. Use of these supplements may allow for reduced doses of pain relievers, such as nonsteroidal anti-inflammatory drugs (NSAIDs, like ibuprofen, naproxen), in patients with osteoarthritis. Glucosamine is generally well tolerated; reported side effects include stomach upset, drowsiness, insomnia, headache, skin reactions, sun sensitivity, and nail toughening. Dietary supplements like glucosamine are not strictly regulated by the US Food and Drug Administration and have not been thoroughly studied in the clinical setting. Thus, these products are not required to be tested for effectiveness, purity, or safety. In general, dietary supplements should only be taken under the supervision of your health care provider. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Michelle McDermott, PharmD

Q: I am having some cartilage and joint problems with my knees. Should I try glucosamine and chondroitin? Should I use a topical gel instead?

A: Glucosamine is a naturally-occurring substance that exists in healthy cartilage and fluid around the joints. Glucosamine is often taken as a supplement, along with chondroitin, which is a substance derived from cartilage. The combination of glucosamine and chondroitin is marketed for various medical conditions. According to the Natural Standard Research Collaboration Glucosamine Monograph, there is some evidence that glucosamine is effective for mild-to-moderate cases of knee osteoarthritis and may allow for lesser doses of non-steroidal anti-inflammatory drugs (NSAIDs). According to the Natural Standard Research Collaboration Glucosamine Monograph, possible side effects with glucosamine may include upset stomach, drowsiness, insomnia (trouble going to sleep or staying asleep), headache, skin reactions, sensitivity to the sun, and toughening of nails. Also, it is still unknown if glucosamine can change blood sugar levels. Some studies report that glucosamine taken by mouth does not affect blood sugar, whereas some other studies report that glucosamine taken by mouth affects blood sugar. Because treatment of knee pain depends on several patient specific factors, please consult with your health care provider regarding the most appropriate treatment options for you. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kristen Dore, PharmD

By Frieda Wiley, PharmD | Medically Reviewed by Robert Jasmer, MD

Latest Update: 2015-05-18



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Dolorex Indications, Side Effects, Warnings, Dolorex

Dolorex

Dolorex is used for:

Treating mild to moderate aches and pains associated with headache, muscle and joint soreness, backache, menstrual cramps, colds and flu, sinusitis, toothache, and minor pain from arthritis, and to reduce fever. It may also be used to treat other conditions as determined by your doctor.

Dolorex is an analgesic, antihistamine, and antipyretic combination. It works by blocking substances in the body that cause fever, pain, and inflammation. It also blocks histamine, which causes sneezing and itchy, watery eyes.

Do NOT use Dolorex if:

you are allergic to any ingredient in Dolorex

you have lung problems (asthma, emphysema, chronic obstructive pulmonary disease [COPD]), difficulty urinating due to an enlarged prostate, glaucoma, kidney or liver problems, or blood clotting problems

you are taking medicine for blood clotting or sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dolorex:

Some medical conditions may interact with Dolorex. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have bleeding problems, blood vessel problems in the brain, blockage of the stomach, chickenpox, flu, rheumatoid arthritis, Kawasaki syndrome, prostate problems, blockage of the urinary tract, or difficulty urinating

Some MEDICINES MAY INTERACT with Dolorex. Tell your health care provider if you are taking any other medicines, especially any of the following:

Isoniazid or sodium oxybate because the risk of side effects may be increased

Blood thinners (eg, warfarin) because the risk of side effects, including the risk of bruising or bleeding, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dolorex may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dolorex:

Use Dolorex as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Dolorex with food and a large glass of water or milk to reduce stomach irritation.

If you miss a dose of Dolorex and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dolorex.

Important safety information:

Dolorex may cause drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Dolorex. Using Dolorex alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

Dolorex contains acetaminophen. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains acetaminophen. If it does or if you are uncertain, contact your doctor or pharmacist.

Avoid taking medicines that cause drowsiness (eg, sedatives, tranquilizers) while taking Dolorex. Dolorex will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.

Do not exceed the recommended dosage or take Dolorex for longer than prescribed without checking with your doctor.

If you consume 3 or more alcohol-containing drinks every day, ask your doctor whether you should take Dolorex or other pain relievers/fever reducers. Acetaminophen may cause liver damage. Alcohol use combined with Dolorex may increase your risk for liver damage.

A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

If you are taking Dolorex for pain or fever and your symptoms do not improve within 10 days or if they become worse, check with your doctor.

Before you have any medical or dental treatments or surgery, tell the doctor or dentist that you are taking Dolorex.

Do not give Dolorex to a child or teenager who has chickenpox, the flu, or another viral infection. Use of Dolorex for treating the symptoms of a viral infection may cause a serious illness called Reye syndrome.

Dolorex is not recommended for use in CHILDREN younger than 6 years of age. Safety and effectiveness in this age group have not been established.

PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Dolorex during pregnancy. Dolorex is excreted in breast milk. Do not breast-feed while taking Dolorex.

Possible side effects of Dolorex:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; dry mouth, nose, or throat; heartburn; nausea; thickening of mucus in the nose and throat; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black stools; confusion; dark urine or pale stools; decreased urination; diarrhea; difficulty swallowing; dizziness; hearing loss; hoarseness; persistent sore throat or other signs of infection; ringing in the ears; severe stomach pain; unusual bruising or bleeding; unusual tiredness; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately. Symptoms may include abnormal behavior; dark urine; excessive sweating; extreme tiredness; fast or deep breathing; loss of consciousness; ringing in the ears; stomach pain; vomiting.

Proper storage of Dolorex:

Store at room temperature, 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dolorex out of the reach of children and away from pets.

General information:

If you have any questions about Dolorex, please talk with your doctor, pharmacist, or other health care provider.

Dolorex is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Dolorex or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Dolorex. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Dolorex. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Dolorex.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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Amaryl (Glimepiride) Side Effects, Interactions, Warning, Dosage & Uses, Glimeride

DRUG DESCRIPTION

AMARYL is an oral sulfonylurea that contains the active ingredient glimepiride. Chemically, glimepiride is identified as 1-[[p-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) ethyl]phenyl]sulfonyl]-3-(trans - 4-methylcyclohexyl)urea (C 24 H 34 N 4 O 5 S) with a molecular weight of 490.62. Glimepiride is a white to yellowish-white, crystalline, odorless to practically odorless powder and is practically insoluble in water.

The structural formula is:

AMARYL tablets contain the active ingredient glimepiride and the following inactive ingredients: lactose (hydrous), sodium starch glycolate, povidone, microcrystalline cellulose, and magnesium stearate. In addition, AMARYL 1 mg tablets contain Ferric Oxide Red, AMARYL 2 mg tablets contain Ferric Oxide Yellow and FD&C Blue #2 Aluminum Lake, and AMARYL 4 mg tablets contain FD&C Blue #2 Aluminum Lake.

What are the possible side effects of glimepiride (Amaryl)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

severe skin rash, itching, redness, or irritation;

pale skin, easy bruising or bleeding, fever, unusual weakness;

numbness or tingly feeling;

trouble breathing;

feeling like you might pass out;

dark urine, clay-colored stools;

upper stomach pain, low fever, jaundice (yellowing of the skin or.

What are the precautions when taking glimepiride (Amaryl)?

Before taking glimepiride, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, thyroid disease, certain hormonal conditions (adrenal/pituitary insufficiency, syndrome of inappropriate secretion of antidiuretic hormone-SIADH), electrolyte imbalance (hyponatremia).

You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels. Do not drive, use machinery, or do any activity that requires alertness or clear vision until.

Last reviewed on RxList: 9/13/2016 This monograph has been modified to include the generic and brand name in many instances.



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Dilacor Xr Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Dilacor Xr

Dilacor XR

GENERIC NAME(S): DILTIAZEM HCL

Uses

Diltiazem is used to treat high blood pressure (hypertension ) and prevent chest pain (angina ). Lowering high blood pressure helps prevent strokes, heart attacks. and kidney problems. When used regularly, diltiazem can decrease the number and severity of episodes of chest pain from angina. It may help increase your ability to exercise .

Diltiazem is called a calcium channel blocker. It works by relaxing blood vessels in the body and heart so blood can flow more easily. Diltiazem also lowers your heart rate. These effects help the heart work less hard and lower blood pressure .

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

Diltiazem may also be used to control your heart rate if you have a fast/irregular heartbeat (such as atrial fibrillation ).

How to use Dilacor XR

Take this medication by mouth without food, usually once daily before breakfast or as directed by your doctor. Swallow the capsules whole. Do not crush or chew the capsules. Doing so can release all of the drug at once and may increase your risk of side effects.

Your doctor may gradually increase your dose. Follow your doctor's instructions carefully. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. For the treatment of high blood pressure, it may take 2 weeks before you get the full benefit of this drug.

This medication must be taken regularly to prevent angina. It should not be used to treat angina when it occurs. Use other medications (such as nitroglycerin placed under the tongue ) to relieve an angina attack as directed by your doctor. Consult your doctor or pharmacist for details.

Tell your doctor if your condition worsens (for example, your chest pain worsens or your routine blood pressure readings increase).

Side Effects

Dizziness. lightheadedness, weakness. nausea. flushing, constipation. and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To lower the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: fainting. slow/irregular/pounding/fast heartbeat, swelling ankles /feet, shortness of breath, unusual tiredness, unexplained/sudden weight gain. mental/mood changes (such as depression. agitation), unusual dreams. severe stomach /abdominal pain. severe constipation. dark urine, persistent nausea/vomiting. yellowing eyes /skin .

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking diltiazem, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain types of heart rhythm problems (such as sick sinus syndrome/atrioventricular block), liver disease, kidney disease, heart failure, narrowing of any part of the stomach/intestines.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Older adults may be more sensitive to the side effects of this drug, especially dizziness, constipation, or swelling ankles/feet.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: amiodarone, digoxin, fingolimod.

Other medications can affect the removal of diltiazem from your body, which may affect how this medication works. Examples include cimetidine, quinidine, St. John's wort, azole antifungals such as ketoconazole, macrolide antibiotics such as erythromycin, rifamycins including rifabutin and rifampin.

Diltiazem may also affect how your body gets rid of many drugs (such as aprepitant/fosaprepitant, buspirone, ivabradine, certain anti-seizure drugs including carbamazepine, certain benzodiazepines including triazolam and midazolam).

Check the labels on all your medicines (such as cough-and-cold products, diet aids, nonsteroidal anti-inflammatory drugs-NSAIDs for pain/fever reduction) because they may contain ingredients that could increase your blood pressure or heart rate (such as pseudoephedrine, phenylephrine, ibuprofen, naproxen). Ask your pharmacist about using these products safely.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others. Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.

Laboratory and/or medical tests (such as kidney/liver function tests, pulse, blood pressure, EKG) may be performed from time to time to monitor your progress or check for side effects. Consult your doctor for more details.

There are different brands and types of this medication available. Many do not have the same effects. Do not change brands or types without consulting your doctor or pharmacist.

Have your blood pressure checked regularly while taking this medication. Learn how to monitor your own blood pressure at home, and share the results with your doctor.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medication away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised February 2016. Copyright(c) 2016 First Databank, Inc.

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Ranfen - 200 Tablets; Ranfen - 400 Tablets, Ranfen

PROPRIETARY NAME (and dosage form):

RANFEN 200 Tablets RANFEN 400 Tablets

COMPOSITION: Ranfen 200 Tablets Each film coated tablet contains ibuprofen 200 mg Ranfen 400 Tablets Each film coated tablet contains ibuprofen 400 mg

PHARMACOLOGICAL CLASSIFICATION: A 3.1 Antirheumatics (anti-inflammatory agents)

PHARMACOLOGICAL ACTION: Mechanism of Action Ibuprofen acts by inhibiting the activity of enzyme cyclo-oxygenase, resulting in decreased formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Pharmacokinetics and Metabolism Ibuprofen is rapidly absorbed after oral administration and peak concentrations in plasma are observed after 1 to 2 hours. The half - life in plasma is about 2 hours. Ibuprofen is extensively (99%) bound to plasma proteins. Ibuprofen passes slowly into synovial spaces and may remain there in higher concentration as the concentrations in plasma decline. The excretion of ibuprofen is rapid and complete. More than 90% of an ingested dose is excreted in the urine as metabolites or their conjugates, and no ibuprofen per se is found in the urine. The major metabolites are a hydroxylated and a carboxylated compound.

INDICATIONS: Ibuprofen is indicated: For the treatment of rheumatic diseases such as: * Rheumatoid arthritis * Osteoarthritis * Ankylosing spondylitis * Juvenile rheumatoid arthritis For the relief of mild to moderate pain especially when anti - inflammatory actions may also be desired e. g. following dental or obstetric surgery, and for relief of musculoskeletal pain due to soft tissue athletic injuries (strains or sprains). For the relief of pain and inflammation of acute gouty arthritis. In the treatment of painful nonrheumatic inflammatory conditions such as athletic injuries, bursitis, capsulitis, synovitis, tendinitis or tenosynovitis. For reduction of fever. For the relief of pain associated with primary dysmenorrhoea.

CONTRA-INDICATIONS: Except under special circumstances this medication should not be used when the following medical problems exist:-

History of severe allergic reaction such as anaphylaxis or angioedema, induced by aspirin or other NSAIDs. Because of the possibility of cross-sensitivity due to structural relationships which exists among non-steroidal anti-inflammatory medicines, acute allergic reactions are likely to occur in patients who have exhibited allergic reactions to these compounds.

Aspirin-induced nasal polyps associated with bronchospasm. (high risk of severe allergic reactions because of cross sensitivity).

Children under the age and 2 years.

Active peptic ulceration.

Safety in pregnancy and lactation has not been established.

WARNINGS: Regular use of NSAID's during the third trimester of pregnancy may result in premature closure of the foetal ductus arteriosus in utero and possibily in persistent pulmonary hypertension of the new born. The onset of labour may be delayed and its duration increased.

DOSAGE AND DIRECTIONS FOR USE: Usual adult dose: Adults: The recommended dosage is 1200 mg daily in divided doses. In severe cases the initial dose in the acute phase may be increased, until the acute phase has been brought under control. Maximum daily dose: 2,4 g per day. Acute gout: 2400 mg daily either as 800 mg, 8 hourly or 600 mg, 6 hourly until acute symptoms have been relieved. If acute symptoms do not resolve within 3 days, consult a doctor. Juvenile Rheumatoid Arthritis: Total daily dose is 20 mg/kg of body weight in divided doses. Pyrexia and pain: 20 mg/kg/day in divided doses.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS: Side effects: Cardiovascular system: Tachycardia, flushing, increase in blood pressure. Central nervous system: Confusion, hallucinations, mental depression, peripheral neuropathy, tinnitus, drowsiness, insomnia. Gastro-intestinal system: Epigastric pain or discomfort, gastritis, haematemesis, gastro-intestinal perforation, gastro-intestinal ulceration Dermatological: Allergic dermatitis, erythema multiforme, Stevens-Johnson Syndrome, toxic epidermal necrolysis. Renal: Haematuria, cystitis, renal impairment or failure, polyuria, fluid retention/ oedema. acute renal failure, interstitial nephritis, nephrotic syndrome Haematological: Agranulocytosis, anaemia, aplastic anaemia, eosinophilia, haemolytic anaemia, leukopaenia, thrombocytopaenia. Hypersensitivity reactions: Angiitis, angioedema, bronchospastic allergic reactions, allergic rhinitis, serum sickness like reaction, systemic lupus erythematosus, aseptic meningitis. Ophthalmic: Amblyopia, blurred or double vision, conjunctivitis, dry irritated or swollen eyes, scotomata. Oral: Aphthous stomatitis, gingival ulcerations. Ear, Nose and Throat: Decreased hearing or any change in hearing, epistaxis, Hepatic effects: Hepatitis Pancreatic effects: Pancreatitis Precautions Cross-sensitivity and/or related problems Patients sensitive to one of the NSAIDs, may also be sensitive to any of the other NSAIDs. NSAIDs may cause bronchoconstriction or anaphylaxis in aspirin-sensitive asthmatics, especially those with aspirin induced nasal polyps, asthma, and other allergic reactions (the “aspirin triad”). Geriatrics NSAID-induced gastro-intestinal ulceration and/or bleeding may be more likely to cause serious consequences, including fatalities, in geriatric patients than in younger adults. In addition, elderly patients are more likely to have age-related renal function impairment, which may increase the risk of NSAID-induced hepatic and renal toxicity and may also require dosage reduction to prevent accumulation of the medication. Also, careful monitoring of the patient is recommended. Dental NSAIDs may cause soreness, irritation, or ulceration of oral mucosa. Ibuprofen may rarely cause leukopaenia and/or thrombocytopaenia, which may result in an increased incidence of microbial infection, delayed healing, and gingival bleeding. If leukopaenia or thrombocytopaenia occurs, dental work should be deferred until blood counts have returned to normal, and patients should be instructed in proper oral hygiene, including caution in use of regular tooth brushes, dental floss and toothpicks. Surgical Caution is recommended in patients who require surgery. Most NSAIDs inhibit platelet aggregation and may prolong bleeding time, which may increase intra - and postoperative bleeding. Recovery of platelet function may occur within one day after discontinuation of ibuprofen. Consideration should be given to discontinuing NSAID treatment for an appropriate length of time prior to elective surgery, depending on the potency and duration of effect of the individual agent on platelet aggregability. Special precautions

Mild allergic reaction such as allergic rhinitis, urticaria or skin rash induced by aspirin or other NSAIDs

Conditions such as compromised cardiac function, congestive heart disease, pre-existing oedema, renal function impairment.

Conditions predisposing to gastrointestinal toxicity, such as alcoholism, inflammatory or ulcerative disease of upper or lower GI tract, including crohn’s disease, diverticulitis, peptic ulcer disease, or ulcerative colitis.

Haemophilia or other bleeding problems including coagulation or platelet function disorders.

Hepatic cirrhosis or hepatic function impairment.

Renal function impairment

Systemic lupus erythematosus

In view of the product's inherent potential to cause fluid retention, heart failue may be precipitated in some compromised patients.

Interactions Paracetamol: Prolonged concurrent use of paracetamol with ibuprofen may increase the risk of adverse renal effects; it is recommended that patients be under close medical supervision while receiving such combined therapy. Alcohol or corticosteroids or chronic therapeutic use of corticotrophin or potassium supplements: Concurrent use with ibuprofen may increase the risk of gastrointestinal side effects, including ulceration or haemorrhage. Anticoagulants (coumarin or indandione derivative) or heparin or thrombolytic agents (e. g. Streptokinase, Urokinase): Inhibition of platelet aggregation by ibuprofen and possibility of ibuprofen-induced gastrointestinal ulceration or bleeding, may be hazardous to patients receiving anticoagulant or thrombolytic therapy. Oral antidiabetic agents or insulin: Ibuprofen may increase the hypoglycemic effect of these medications because prostaglandins are directly involved in regulatory mechanisms of glucose metabolism and possibly because of displacement of the oral antidiabetics from serum proteins. Hence, dosage adjustments of antidiabetic agent may be necessary. Antihypertensives or diuretics: Increase monitoring of the response to an antihypertensive agent may be advisable when ibuprofen is used concurrently because it has been shown to reduce or reverse the effects of antihypertensives, possibly by renal prostaglandin synthesis and/or by causing sodium and fluid retention. Other NSAIDs (used concurrently with ibuprofen): Concurrent use of two or more NSAIDs is not recommended; concurrent therapy may increase the risk of gastrointestinal toxicity, including ulceration or haemorrhage, without providing additional symptomatic relief. Concurrent administration of two or more NSAIDs may alter the pharmacokinetic profile of at least one of the medications; which may alter the therapeutic effect and/or increase the risk of adverse effects, specifically aspirin decreases the bioavailability of ibuprofen by 50%. Bone marrow depressants: Leukopaenic and/or thrombocytopaenic effects of these medications may be increased with concurrent or recent therapy; dosage adjustment of the bone marrow depressant, if necessary, should be based on blood counts. Digoxin: Ibuprofen has been reported to increase digoxin plasma concentration. Cefamandole or valproic acid: These medications may cause hypoprothrombinaemia; in addition, valproic acid may inhibit platelet aggregation; concurrent use with ibuprofen may increase the risk of bleeding because of additive interferences with platelet function and/or the potential occurrence of ibuprofen-induced gastrointestinal ulceration or haemorrhage. Ciclosporin or Gold Compounds and other nephrotoxic compounds: Inhibition of renal prostaglandin activity by ibuprofen may increase the plasma concentration of ciclosporin and/or the risk of ciclosporin induced nephrotoxicity; patients should be carefully monitored during concurrent use. Lithium Ibuprofen has been reported to increase the steady state concentration of lithium possibly by decreasing its renal clearance. Methotrexate NSAIDs may decrease protein binding and/or renal elimination of methotrexate, resulting in increased and prolonged methotrexate plasma concentrations and increased risk of toxicity, especially during high dose methotrexate infusion therapy. Laboratory Value Alterations Bleeding time may be prolonged with the use of ibuprofen. Decrease in blood glucose concentration has been reported with ibuprofen.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT See side-effects and special precautions. Treatment is symptomatic and supportive.

IDENTIFICATION: Ranfen 200 Tablets Peach-red coloured, round biconvex film coated tablets with intact coating. Ranfen 400 Tablets Peach-red coloured, round, biconvex film coated tablets with intact coating.

PRESENTATION: Ranfen 200 Tablets White HDPE bottle containing 28 tablets White HDPE bottle containing 500 tablets White HDPE bottle containing 1000 tablets. Ranfen 400 Tablets White HDPE bottle containing 1000 tablets.

STORAGE INSTRUCTIONS: Ranfen 200 Tablets: Store in well closed containers, below 30°C, protected from moisture. Ranfen 400 Tablets: Store in well closed containers, below 25°C, protected from moisture. Keep out of reach of children.

REGISTRATION NUMBER Ranfen 200 Tablets . 30/3.1/0440 Ranfen 400 Tablets . 34/3.1/0446

NAME AND BUSINESS ADDRESS OF THE APPLICANT RANBAXY (SA) (PTY) LTD Third Floor, Outspan House, 1006 Lenchen Avenue North, Centurion, Pretoria

DATE OF PUBLICATION OF THIS PACKAGE INSERT:

Updated on this site: March 2003 Source: Pharmaceutical Industry SAEPI HOME PAGE TRADE NAME INDEX GENERIC NAME INDEX FEEDBACK Information presented by Malahyde Information Systems © Copyright 1996-2006



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Hemorrhoidal Cream Rectal Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Jelliproct

Hemorrhoidal Cream rectal

Uses

This medication is used to temporarily relieve swelling, burning, pain, and itching caused by hemorrhoids. This product contains phenylephrine and pramoxine .

Phenylephrine is a sympathomimetic amine that works by temporarily narrowing the blood vessels in the area. This effect decreases swelling and discomfort. Pramoxine belongs to a class of drugs known as local anesthetics. It works on nerves in the skin to block or reduce the feeling of pain and itching .

Some products may also contain substances (e. g. cocoa butter, hard fat, mineral oil. shark liver oil) that soothe or form a protective barrier to prevent too much irritating contact with stool.

How to use Hemorrhoidal Cream rectal

Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist. Before use, clean the area with mild soap and water, rinse well, and pat dry.

Apply the product to the skin of the affected area up to 4 times daily, usually in the morning and bedtime. or after each bowel movement. or as directed by your doctor. To apply this product inside the lower part of the anus. use the applicator tip/cap/nozzle. Follow all instructions in the product package, or use as directed by your doctor. Do not apply the product high up inside the rectum.

Dosage is based on your medical condition and response to treatment. Do not use more often or for a longer time than recommended.

If symptoms do not improve within 7 days, if bleeding/worsening pain occurs, or if you think you may have a serious medical problem, consult your doctor promptly.

Side Effects

This medication does not usually have bothersome side effects when used as directed. Mild pain/stinging may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Stop using this medication and tell your doctor right away if any of these rare but very serious side effects occur: fast/irregular heartbeat. pounding headache. nervousness, shakiness (tremor), trouble sleeping .

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching/swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using this product, tell your doctor or pharmacist if you are allergic to phenylephrine; or to pramoxine; or to any of its ingredients; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

If you have any of the following health problems, consult your doctor or pharmacist before using this product: diabetes. heart problems (e. g. chest pain. heart attack ), high blood pressure. overactive thyroid (hyperthyroidism), difficult urination due to blockage (e. g. enlarged prostate ).

Do not use this product in children 12 years or younger without talking with the doctor.

During pregnancy. this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast - feeding.

Interactions

If you are using this product under your doctor's direction, your doctor or pharmacist may already be aware of possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Check the labels on all your medicines (e. g. cough-and-cold products, diet aids ) because they may contain ingredients that could increase your heart rate and blood pressure. Ask your pharmacist about using those products safely.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

To maintain normal bowel function and reduce the risk of hemorrhoids, eat a proper diet high in fiber, drink 6 to 8 glasses of water each day, and exercise regularly.

Missed Dose

If you are using this product on a regular schedule and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature at 68-77 degrees F (20-25 degrees C). Different brands of this medication may have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

Images

No data available at this time.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Welcome to Stuff4Beauty salon hair products and product reviews.

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Most all products advertised on this site are in stock. Often you will receive your order within 4 - 7 business days of ordering, but not always. A few examples that could cause a delay (extra time) in order filling is if you order a product in high demand, gallons or large numbers or liters of product. In these special order cases please allow 1-21 days for your order to be shipped from our location - and then, please allow 4 additional days for the package to arrive after it has been shipped

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**Store Phone Hours:

Monday's: Noon to 5pm Central Time Tues. through Thursday: 11am to 5pm Central Time Friday's: CLOSED Weekends (Sat. and Sun): CLOSED

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Our phone and fax number is toll free to the USA 1-866-458-4441 all others, please email.

Contact By Snail Mail:

Stuff4Beauty PO Box 532 Shelbyville Il 62565

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Stuff4Beauty. com is your premier online store where you can purchase brand name, discounted salon products, skin care products and tanning lotions. All of our customers are handled with the utmost care to ensure that your shopping experience is a quick and pleasant one. We have several locations across the USA, our main location is in Illinois. Our policies are outlined on this page.

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Lucille - Walking Dead Wiki, Lucille

Lucille

This article is a disambiguation page for Lucille. The following is a list of links to pages that might share the same title. Please follow one of the disambiguation links below or search to find the page you were looking for if it is not listed. If an internal link led you here, you may wish to change the link to point directly to the intended article.

Lucille is a name that refers to two objects in The Walking Dead medias, appearing in both the TV Series and Comic Series. as well as a character from the Comic Series.

TV Series

Lucille - A baseball bat coated in barb wire that Negan uses as his primary weapon.

Comic Series

Lucille - A baseball bat coated in barb wire that Negan uses as his primary weapon and apparently has sexual fantasies about.

Lucille - Negan's wife.



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Mobic - Pain Relief, Flogosine

Mobic is used to relieve the pain and stiffness of osteoarthritis and rheumatoid arthritis.

Take Mobic exactly as directed by your physician. It is recommended that you take it with a glass of water and a meal (to avoid an empty stomach).

If you miss a dose of Mobic, then skip it and continue with your regular schedule. However, do not take a double dose to make up for the missed dose.

Store Mobic at room temperature away from heat, light and moisture.

Some of the symptoms of a Mobic overdose include nausea, vomiting, stomach pain and bleeding. In extreme cases, it may lead to a heart attack or even coma. Seek medical attention immediately if you suspect an overdose.

Consult your doctor before starting treatment if you are allergic to aspirin, have asthma or experience difficulty breathing while using Mobic. Do not smoke, have alcohol or take steroidal medications while using this drug. Use only if prescribed.

Do not use Mobic if:

you are allergic to any ingredient in Mobic; you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, celecoxib); you have recently had or will be having bypass heart surgery; you have a peptic ulcer; you are in the last 3 months of pregnancy. Contact your doctor or health care provider right away if any of these apply to you.

Important : Do not drive or perform other possibly unsafe tasks until you know how you react to it. Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor. Mobic is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist. Do not take aspirin while you are using Mobic unless your doctor tells you to. Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be performed while you use Mobic. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Use Mobic with caution in the elderly; they may be more sensitive to its effects, especially stomach bleeding and kidney problems. Caution is advised when using Mobic in children; they may be more sensitive to its effects, especially diarrhea, fever, headache, stomach pain, and vomiting. Mobic should be used with extreme caution in children younger than 2 years old; safety and effectiveness in these children have not been determined. Pregnancy and breast-feeding: Mobic may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Mobic while you are pregnant. It is not known if Mobic is found in breast milk. Do not breast-feed while taking Mobic.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach upset; trouble sleeping. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

Mobic is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.



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Nadolol - Side Effects, Dosage, Interactions, Naponal

Nadolol

Nadolol is the generic form of the brand-name medicine Corgard, which is used to treat high blood pressure and chest pain.

This prescription medicine is also sometimes given to prevent migraine headaches. In addition, it's used to treat Parkinson's disease (a movement disorder) and irregular heartbeat.

Nadolol belongs to a class of drugs called beta-blockers. It works by relaxing blood vessels and slowing the heart rate.

The U. S. Food and Drug Administration (FDA) approved nadolol in 1979.

Nadolol Warnings

Nadolol contains a black box warning because it could cause chest pain or a heart attack if you stop taking it suddenly.

Don't stop using this medicine without first talking to your doctor. Your healthcare provider will gradually take you off nadolol.

Before you use this medicine, tell your doctor if you have, or have ever had:

Breathing conditions, such as bronchitis, asthma, sleep apnea, or chronic obstructive pulmonary disease (COPD)

Heart failure, a heart blockage, a slow heart rate, heart disease, chest pain, or any other heart problems

Blood vessel problems

Circulation problems

Stroke

A thyroid disorder

Liver or kidney disease

Diabetes

Psoriasis (a skin condition)

Myasthenia gravis (a chronic neuromuscular disease)

Pheochromocytoma (a tumor on a small gland near the kidneys)

Depression

Severe allergies

Tell your healthcare provider that you're using this medicine before having any type of surgery, including a dental procedure.

If you have diabetes, this medicine may mask the symptoms of a low blood sugar episode. Monitor your blood sugar levels carefully while using nadolol.

Your doctor may recommend following a diet and exercise plan while taking nadolol. Follow these instructions carefully.

Keep all appointments with your doctor and laboratory while taking this medicine. You'll need to have your blood pressure and heart rate checked regularly.

Your doctor may also order other tests to check your body's response to this medicine.

Pregnancy and Nadolol

It's not known whether nadolol could harm an unborn baby if it's taken during pregnancy.

Tell your doctor if you're pregnant, or plan to become pregnant before using this medicine.

This drug passes into breast milk. Don't breastfeed a baby without first talking to your doctor while using nadolol.

Nadolol Side Effects

Common Side Effects of Nadolol

Tell your doctor if any of the following side effects become severe or don't go away:

Mild dizziness or lightheadedness

Tiredness

Headache

Serious Side Effects of Nadolol

Tell your doctor right away if you experience any of the following serious side effects:

Blurred vision or other vision problems

Fainting

Severe dizziness or lightheadedness

Fever, chills, or sore throat

Shortness of breath

Chest pain or discomfort

Slow or irregular heartbeat

Sudden, unexplained weight gain

Swelling of the hands, ankles, or feet

Unusual bleeding or bruising

Pain in the upper right part of the stomach

Yellowing of the skin or eyes

Dark-colored urine

Clay-colored stools

Behavior changes

Hallucinations

Short-term memory problems

Burning, numbness, or tingling

Cold fingers or toes

Signs of a severe allergic reaction, which may include hives, rash, difficulty breathing, tightness in the chest, or swelling of the mouth, lips, face, or tongue

Nadolol Interactions

Tell your doctor about all prescription, nonprescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially:

Reserpine

Thioridazine

Lanoxin (digoxin)

Catapres or Kapvay (clonidine)

Clorpres (clonidine and chlorthalidone)

Adrenaclick or EpiPen (epinephrine)

Other medication for high blood pressure or heart disease

Nonsteroidal anti-inflammatory drugs (NSAIDs), such as Advil or Motrin (ibuprofen) and Indocin or Indo-Lemmon (indomethacin)

Medication for asthma or other breathing disorders

Cold medicines, stimulants, or diet pills

Medicines for diabetes, Parkinson's disease, mood disorders, high cholesterol, or migraines

Dietary supplements

Nadolol and Other Interactions

Nadolol may cause drowsiness.

Don't drive, operate machinery, or perform other activities that require alertness until you know how this medicine affects you.

Nadolol and Green Tea

Green tea may interfere with how nadolol works in your body.

Talk to your doctor about this potential interaction.

Nadolol and Alcohol

Alcohol may worsen certain side effects of nadolol.

Talk to your doctor before drinking alcoholic beverages while using this drug.

Nadolol Dosage

Nadolol comes as a tablet to take by mouth, usually once a day.

Your dose will depend on your medical condition and response to treatment.

Your doctor may start you on a low dose and gradually increase it.

Try to take nadolol around the same time each day, without missing a dose.

You can take this medicine with or without food.

Follow the instructions on your prescription label carefully. Don't take more or less nadolol than is recommended.

It may take a few weeks before you experience the full benefits of this drug.

Continue to take nadolol even if you feel well. Don't stop using it without talking to your doctor.

Nadolol Overdose

Symptoms of a nadolol overdose may include:

Severe dizziness or lightheadedness

Fainting

Difficulty breathing or swallowing

Slow heartbeat

Sudden, unexplained weight gain

Swelling of the hands, ankles, lower legs, or feet

If you suspect an overdose, contact a poison control center or emergency room immediately.

You can get in touch with a poison control center at 800-222-1222.

Missed Dose of Nadolol

If you miss a dose of nadolol, take it as soon as you remember.

But if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular medication schedule.

Don't take extra medicine to make up for a missed dose.



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Necon® 0.5/35 (norethindrone and ethinyl estradiol) Tablets USP

Necon® 10/11 (norethindrone and ethinyl estradiol) Tablets USP

Necon (norethindrone and ethinyl estradiol tablets ) ® 1/50 (norethindrone and mestranol) Tablets USP

Patients should be counseled that this product does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

DRUG DESCRIPTION

Each of the following products is a combination oral contraceptive containing the progestational compound norethindrone and the estrogenic compound ethinyl estradiol:

Necon® 1/35 (norethindrone and ethinyl estradiol tablets ) : Each dark yellow tablet contains 1 mg of norethindrone and 0.035 mg of ethinyl estradiol. Inactive ingredients include D&C Yellow No. 10 Aluminum Lake, microcrystalline cellulose, lactose (anhydrous), magnesium stearate, polacrilin potassium. and povidone. Each white tablet in the Necon (norethindrone and ethinyl estradiol tablets ) ® 1/35 package contains only inert ingredients, as follows: micro - crystalline cellulose, lactose (anhydrous), and magnesium stearate.

Necon (norethindrone and ethinyl estradiol tablets ) ® 0.5/35: Each light yellow tablet contains 0.5 mg of norethindrone and 0.035 mg of ethinyl estradiol. Inactive ingredients include D&C Yellow No. 10 Aluminum Lake, microcrystalline cellulose, lactose (anhydrous), magnesium stearate, polacrilin potassium, and povidone. Each white tablet in the Necon (norethindrone and ethinyl estradiol tablets ) ® 0.5/35 package contains only inert ingredients as listed under white tablets in Necon® 1/35 (norethindrone and ethinyl estradiol tablets ) .

Necon (norethindrone and ethinyl estradiol tablets ) ® 10/11: Each light yellow tablet (10) contains 0.5 mg of norethindrone and 0.035 mg of ethinyl estradiol. Each dark yellow tablet (11) contains 1 mg of norethindrone and 0.035 mg of ethinyl estradiol. Inactive ingredients include D&C Yellow No. 10 Aluminum Lake, microcrys - talline cellulose, lactose (anhydrous), magnesium stearate, polacrilin potassium, and povidone. Each white tablet in the Necon (norethindrone and ethinyl estradiol tablets ) ® 10/11 package contains only inert ingredients as listed under white tablets in Necon® 1/35 (norethindrone and ethinyl estradiol tablets ) .

Each of the following products is a combination oral contraceptive containing the progestational compound norethindrone and the estrogenic compound mestranol:

Necon (norethindrone and ethinyl estradiol tablets ) ® 1/50: Each light blue tablet contains 1 mg of norethindrone and 0.05 mg of mestranol. Inactive ingredients include FD&C Blue No. 1 Aluminum Lake, microcrystalline cellulose, lactose (anhydrous), magnesium stearate, polacrilin potassium, and povidone. Each white tablet in the Necon (norethindrone and ethinyl estradiol tablets ) ® 1/50 package contains only inert ingredients as listed under white tablets in Necon® 1/35 (norethindrone and ethinyl estradiol tablets ) .

The chemical name for norethindrone is 17- hydroxy-19-nor-17a-pregn-4-en-20-yn-3-one, for ethinyl estradiol is 19-nor-17a-pregna - 1,3,5(10)-trien-20-yn-3,17-diol, and for mestranol is 3-methoxy-19-nor-17a-pregna-1,3,5(10)- trien-20-yn-17-ol. The structural formulas are as follows:

What are the possible side effects of birth control pills?

Get emergency medical help if you have any of these signs of an allergic reaction . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using birth control pills and call your doctor at once if you have a serious side effect such as:

sudden numbness or weakness, especially on one side of the body;

sudden and severe headache, confusion, problems with vision, speech, or balance;

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

sudden cough, wheezing, rapid.

Last reviewed on RxList: 3/24/2008 This monograph has been modified to include the generic and brand name in many instances.



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Prostol Review Does This Product Really Work, Prostol

Prostol Review: How Safe and Effective is This Product?

Description of Prostol

196,038 the number of men diagnosed with prostate cancer in the US in the year 2010 alone. Apart from this huge number, there are more men around the world suffering not just from prostate cancer but also from other prostate diseases such as benign prostate hyperplasia (BHP), and prostatitis. Prostate issues have been limiting men and significantly affecting their lives for years.

Nature’s Way, the frontrunner in herbal medicine in the USA, claims to have concocted an innovative prostate supplement the Prostol Dual Action Prostate Formula, that promises to liberate men from the shadows of prostate issues. This formula can be bought for as low as $20.95 per bottle with 60 soft gel capsules making it the cheapest prostate supplement there is in the market.

Prostol Makings

Prostol basically has two key ingredients which have been proven to be clinically significant and effective in the prevention and control of prostate enlargement and deterioration.

Sabal Extract/Saw Palmetto Concentrate . The chief and specific action of Sabal Extract is to deter the action of 5-alpha-reductase, an enzyme responsible for the conversion of the hormone testosterone to the harmful substance dihydrotestosterone (DHT). Studies have shown Sabal Extract’s potency and value in the regulation of the prostate gland’s normal size and function.

Urtica Extract/Nettle Root Concentrate . Urtica Extract contains active anti-inflammatory compounds and it has been shown to improve the urinary problems manifested by patients with prostate problems.

Gelatin

Plant Glycerides

Glycerine

Soybean Oil

Caramel

Titanium Dioxide

Carmine

How Does it Work?

Prostol Dual Action Prostate Formula contains two of the most essentially potent ingredients needed in order to protect and prevent the prostate from deteriorating morphologically and physiologically. Prostol is a synergistic formulation with a dual enzyme inhibitor capacity against 5-alpha-reductase and aromatase. 5-alpha-reductase is an enzyme that men normally produce. As men grow older, they tend to produce more of this enzyme, the role of which is to convert testosterone to dihydrotestosterone (DHT), a male sex hormone that stimulates cell growth, specifically in the prostate gland. Since the concentration of 5-alpha-reductase increases with age, the DHT level also increases resulting in the enlargement of the prostate gland. The action of Prostol is to inhibit 5-alpha-reductase; thereby, maintaining the normal size of the prostate gland. Moreover, this prostate supplement also inhibits the action of aromatase which also promotes unnecessary cellular proliferation of the prostate gland. Apart from this inhibitory mechanism, Prostol also aids in the promotion of normal urine flow in males. Both key ingredients are proven to provide relief in men who complain of urinary problems secondary to prostate issues. These two extracts have been suggested to work well with each other potentiating their beneficial effects.

Pros of Prostol

Firstly, Prostol is manufactured by one of the most, if not the most reputable herbal medicine company in the US. This gives the consumers the assurance that it is of excellent quality. It contains extracts that have been clinically proven to be effective. It is also more affordable as compared to other prostate supplements.

Cons of Prostol

Prostol has only two key ingredients. which makes its beneficial effects limited only to the prostate gland and to a smaller extent the male reproductive system. Additionally, utmost compliance of the consumer is required; otherwise, the effectiveness of the product would be greatly affected.

Does It Really Promote Prostate Health?

This prostate supplement promotes prostate health to a certain extent. Since it only has two key ingredients, the actions of this supplement are limited to the maintenance of normal prostate size and normal urine flow. Prostol, however, does not guarantee prostate protection from other conditions such as prostatitis. It does not contain supportive supplements that would help a lot in the overall and complete well-being of the prostate gland.

Daily Dosage of Prostol

One soft gel capsule twice a day is the recommended dosage of Prostol. It should to be taken with a full glass of water. Continuous use is highly recommended for best results.

Warnings of Prostol

Prostol is double safety sealed with a printed outer shrink wrap film and a printed inner bottle freshness seal. Do not use if either seal is broken or missing. Once opened, the bottle should be stored in a cool and dry place. Make sure that the lid is tightly closed and keep out of reach of children .

Bottom Line

Prostol Dual Action Prostate Formula has been verified to act against enzymes responsible for prostate enlargement which could eventually lead to serious prostate conditions. However, it offers only a limited prostate protection due to the fact that the formulation is inadequate if compared to other prostate supplements these days. However, the product is highly affordable, and is suitable for patients looks for PBH prevention.

Below is the key prostate health products sold in the market today. They are highly efficient in improving prostate concerns. They give you the support you need with the help of their natural groundbreaking ingredients. Above all, these products are tested scientifically and don't cause any side effects. These products are tested for their effectiveness and also don't cost much.

Our Top Prostate Support Choices

**This is a subjective assessment based on the strength of the available information and our estimation of efficacy.

*Results may vary. If you have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as medical advice. Always consult your doctor before using any supplements.

Disclosure of Material Connection . Some of the links in the post above are "associate sales links." This means if you click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

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Author: Dr. Ahmed Zayed

Dr. Ahmed Zayed Helmy holds a baccalaureate of Medicine and Surgery. He has completed his degree in 2011 at the University of Alexandria, Egypt. Dr. Ahmed believes in providing knowledgeable information to readers. Other than his passion for writing, currently he is working as a Plastic surgeon at bank el Ahly hospital and is doing his masters at Ain shams University.

Disclaimer:- This site is owned and operated by Twenty First Century Web, Inc © 2016 All Rights Reserved. The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. You should not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. Your use of this website indicates your agreement to this websites published terms of use and all site policies. All trademarks, registered trademarks and service-marks mentioned on this site are the property of their respective owners.

Copyright © 2003 - 2016 Consumer Health Digest, Inc. All rights reserved. Consumer Health Digest is for informational purposes and should not be considered medical advice, diagnosis or treatment recommendations.



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We are a free monitoring service designed for patients like you who want to be in the driver seat of your medical treatment. We have a community of more than 2.6 million members and offer the services below.

Medication Information Personalized Risk Rating Easy to understand overview Serious Side Effects Printable Medication List

Information you can understand Overview on Safety Alerts & Recalls Overview of Medications & Conditions

Community of patients Members’ Feedback Members Treatment Satisfaction

Health condition information Easy to understand overview Commonly Used Medications

Safety checks Safety Alerts & Recalls Drug - Drug Interaction Drug - Condition Interaction

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Your #1 Choice for Boats for Sale in Maine

Hamlin’s Marine wants you to enjoy every moment on the water.

For over twenty years Hamlin’s Marine has delivered on a simple promise… ”If you purchase a boat from Hamlin’s Marine, we’ll always be there when you need us.” Hamlin’s Marine offers convenience and assurance with our locations in Waterville and Hampden, staff of twenty-five dedicated employees, and a fleet of service trucks.

At Hamlin’s we only sell boats that we can stand behind. Our manufacturers include Bennington Pontoons. Stingray. Mastercraft. Cutwater. Northcoast. Puffin. Alumacraft. Achilles. Scout Boats. and Yamaha Outboards. These manufacturers lead the industry in quality construction, and make it easier to serve you when it matters most.

So come on in and choose from our selection of new and used Pontoon Boats, Tow Boats or any other fishing boats or family fun boats. With two easy locations in Waterville, Maine (Boat Sales and Service) or Hampden, Maine (Boat Sales, Service, and Marina) it couldn't get any more convenient. Choose Hamlin’s Marine as your boat dealer, service center, marina, and indoor storage facility, and we promise you’ll make wonderful memories on the water in Maine.

At Hamlin's Marine we stand behind all of our boats for sale in Maine .

Why Buy From Hamlin's Marine:

31 Years in Business

#1 Yamaha Outboard Dealer in New England for 5 Years in a Row

Alumacraft is America's #1 selling Deep V Aluminum Fishing Boat

Multiple Locations to serve you

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Lake County Indiana Public Library Events Programs Kids Books Teens, Ciplin

Our annual booksale featuring books, movies, audiobooks and more, starts 9/29 for Friends of the Library and 9/30 for the public! Learn more.

Looking for the whole story? Want to build critical thinking skills? You need Opposing Viewpoints in Context: credible, unbiased sources from both sides of over 20,000 hot-button issues. Learn More.

Holiday Hours

Oct. 10, Columbus Day

Library Updates

Happy National Library Card Sign-Up Month!

Tell your friends: getting a library card is easier than ever with our instant access online sign up !

For all those cool kids who already have a card, check our calendar for awesome events happening all month long.

Make sure you're registered before the Lake County deadline, confirm where your polling place is, and find out who's on your ballot (hint: it's not just the Presidential candidates!) We've got all the information you need to make voting a breeze - and as always, we're happy to be a non-partisan source of information for all voters. Learn more about voting here.



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Inpractice® Africa, Ethatyl

Ethionamide

Formulations

Indications and Pharmacology

Indication: used in treatment of multidrug-resistant tuberculosis in combination with other second-line drugs.

Mechanism of action: not precisely defined, appears to inhibit peptide synthesis; may be bacteriostatic or bactericidal depending on concentration.

Pharmacokinetics: Rapidly absorbed and widely distributed in the body; metabolized in liver to active and inactive metabolites; half-life 3 hours. Good penetration of blood–brain barrier.*

Dosage

Adult Dose: 15-20 mg/kg once daily, maximum 1 g/day; dose may be divided or reduced to improve gastrointestinal tolerance. Should be taken with food to increase gastrointestinal tolerance.*

Use in Renal or Hepatic Insufficiency:

Creatinine clearance < 30 mL/min or if patient on haemodialysis: 250-500 mg/day.*

Contraindicated in patients with severe hepatic impairment.

Use in Pregnancy and Breastfeeding: Pregnancy category C. Teratogenicity in animals has been reported. Avoid use in pregnancy.*

≥ 10 yrs of age: adult dose.

< 10 yrs of age: 10 mg/kg/day increased over 1 week to 15-20 mg/kg/day (in 2 doses until well tolerated), maximum 1 g/day.

Tuberculosis meningitis in children: 20 mg/kg daily.*

Warnings

Contraindicated in patients with severe hepatic impairment, porphyria, and those hypersensitive to the drug.

Concomitant administration of pyridoxine may prevent or reduce neurotoxicity.

Use alone or failure to complete full treatment regimen may result in rapid development of resistance. †

Diabetes may be difficult to control after starting this drug.

Ophthalmologic, thyroid function, and laboratory exams (serum transaminases, blood glucose) should be considered before and during therapy.*

Dose may be divided or reduced, or timing of dosage changed to improve gastrointestinal tolerance.

Caution should be used in patients with depression, psychiatric illness, chronic alcoholism, epilepsy, hypothyroidism, and diabetes.

Use alone or failure to complete full treatment regimen may result in rapid development of resistance. ‡

Vitamin B6 (pyridoxine) 150 mg can minimise or prevent peripheral neuropathy.

Pellagra-type encephalopathy responds to niacin treatment.

Assess monthly for signs of hypothyroidism, measure thyroid stimulating hormone every 6 months in adults and every 2 months in children.*

Ethionamide has good penetration of blood–brain barrier, so consider using for miliary tuberculosis or tuberculosis meningitis.*

Drug–Drug Interactions

Increased concentration of concomitant medication: isoniazid .

Potentiation of adverse effects of concomitant medication: cycloserine. terizidone (convulsions and other central nervous system toxicity); pyrazinamide (hepatotoxicity and hyperuricemia)*; ethambutol .*

Considerations for Special Populations

Drug malabsorption may occur with concomitant HIV. †

Diabetes may be difficult to control.

See above for pregnancy and lactation.

Adverse Effects

Gastrointestinal intolerance (nausea, vomiting, anorexia, metallic taste, abdominal discomfort, diarrhoea, weight loss); central nervous system effects (seizures, pellagra-like encephalopathy, acute psychosis, anxiety and depression, optic neuritis, peripheral neuropathy); hepatotoxicity; hypothyroidism, especially in HIV patients or if used with para-aminosalicylic acid.

Gynaecomastia, impotence, amenorrhoea, hypoglycaemia, hypersensitivity, alopecia, photosensitivity, arthralgia may also occur in rare instances.

*Information from Aurum Institute Drugs on the Go. † Information from US Prescribing Information.

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The materials published on the inPractice® Africa Site were originally developed with support from the American people delivered through the US Agency for International Development (USAID). The contents are the responsibility of the Foundation for Professional Development and Clinical Care Options and do not necessarily reflect the opinion of USAID or the US Government. The materials published on the inPractice Africa Site reflect the views of the reviewers or authors of the material, not those of the Foundation for Professional Development, Clinical Care Options, LLC, or the organizations providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved for use in your clinical setting. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.



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