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Informacion: Fluconazol Antimicotico sistemico Composicion:

Cada capsula contiene 150mg Fluconazol base. Indicaciones:

Onicomicosis (Tinea ungium). Dermatomicosis (Tinea pedis, Tinea corporis, Tinea cruris, Pitiriasis versicolor). Candidiasis genital (aguda o recurrente). Balanitis candidiasica. Candidiasis de mucosa. Candidiasis sistemica e infecciones invasivas por Candida, como por ejemplo candidemia o candidiasis diseminada. Criptococosis pulmonares o cutaneas y meningitis criptococosica. Prevencion de las infecciones micoticas en pacientes predispuestos a tales infecciones como resultado de su inmuno incompetencia. Contraindicaciones:

Pacientes hipersensibles a los componentes triazolados. No se debe prescribir a mujeres embarazadas ni en periodo de lactancia. No se recomienda su uso en ninos menores de 16 anos. La combinacion de fluconazol con cisaprida esta totalmente contraindicada. Precauciones:

La administracion simultanea de fluconazol y fenitoina puede incrementar significativamente los niveles de esta ultima. El Fluconazol aumenta la concentracion sanguinea de las sulfonilureas. Efectos Colaterales:

Pueden aparecer efectos adversos a nivel gastrointestinal como nauseas, vomitos, dolor abdominal, diarrea y flatulencia. Tambien se ha observado elevacion temporal de las enzimas hepaticas Dosificacion y Administracion:

En adultos se recomienda la siguiente pauta posologica: A - Candidiasis genital: Una dosis oral unica de 150 mg de fluconazol para cada miembro de la pareja. B - Dermatomicosis: 150 mg de Fluconazol una vez por semana durante 2 a 6 semanas. C - Onicomicosis: 150 mg de Fluconazol una vez por semana durante 6 a 12 meses. El fluconazol debe ser administrado despues de los alimentos. Presentacion:

Blister con 1 capsula.

?Para cuales condiciones o enfermedades se prescribe este medicamento?

El fluconazol se usa para tratar las infecciones por hongos, incluidas las infecciones por levaduras de la vagina, la boca, la garganta, el esofago (el conducto que va desde la boca hasta el estomago), el abdomen (el area entre el pecho y la cintura), los pulmones, la sangre y otros organos. El fluconazol tambien se usa para tratar la meningitis (infeccion de las membranas que recubren el cerebro y la columna vertebral) provocada por hongos. El fluconazol tambien se usa para prevenir las infecciones por levaduras en pacientes que es probable que se infecten porque estan siendo tratados con quimioterapia o radioterapia antes de un trasplante de medula osea (reemplazo del tejido esponjoso enfermo dentro de los huesos con tejido sano). El fluconazol pertenece a una clase de antimicoticos llamados triazoles. Actua haciendo mas lento el crecimiento de los hongos que causan la infeccion. ?Como se debe usar este medicamento?

La presentacion del fluconazol es en tabletas y en una suspension (liquido) para administrarse por via oral. Por lo general, suele tomarse con o sin alimentos, una vez al dia. Quizas deba tomar una sola dosis de fluconazol o quizas deba tomar fluconazol durante varias semanas o mas. La duracion del tratamiento depende de su afeccion y de que tan bien responde al fluconazol. Siga atentamente las instrucciones del medicamento recetado, y pidales a su medico o a su farmaceutico que le expliquen cualquier cosa que no entienda. Tome el fluconazol segun lo indicado. No aumente ni disminuya la dosis, ni la tome con mas frecuencia que la indicada por su medico.

Es posible que su medico le indique una dosis doble de fluconazol el primer dia de su tratamiento. Siga estas instrucciones al pie de la letra.

Agite bien el liquido antes de cada uso para mezclar uniformemente el medicamento.

Deberia comenzar a sentirse mejor a los pocos dias de tratamiento con fluconazol. Si los sintomas no mejoran, o si empeoran, llame a su medico.

Siga usando fluconazol hasta que su medico le indique que deje de hacerlo, aunque se sienta mejor. No deje de tomar fluconazol sin consultar a su medico. Si deja de tomar fluconazol demasiado pronto, es posible que su infeccion regrese despues de poco tiempo.

Pidales a su medico o a su farmaceutico una copia de la informacion del fabricante para el paciente. ?Que otro uso se le da a este medicamento? Volver al comienzo

El fluconazol, a veces, tambien se usa para tratar infecciones graves por hongos, que comienzan en los pulmones y pueden propagarse a traves del cuerpo, e infecciones por hongos de los ojos, la prostata (un organo reproductor masculino), la piel y las unas. El fluconazol, a veces, tambien se usa para prevenir las infecciones por hongos en las personas que son mas propensas a infectarse porque tienen el virus de la inmunodeficiencia humana (VIH) o cancer o han tenido una operacion de trasplante (cirugia para extraer un organo y reemplazarlo con el organo de un donante o con un organo artificial). Consulte a su medico sobre los posibles riesgos de usar este medicamento para tratar su afeccion.

Este medicamento puede recetarse para otros usos; pidales mas informacion a su medico o a su farmaceutico. ?Cuales son las precauciones especiales que debo seguir? Volver al comienzo Antes de tomar fluconazol:

Informe a su medico y a su farmaceutico si es alergico al fluconazol, a otros medicamentos antimicoticos como el itraconazol (Sporanox), ketoconazol (Nizoral), posaconazol (Noxafil) o voriconazol (Vfend), a algun otro medicamento o a alguno de los ingredientes en las tabletas o en la suspension de fluconazol. Pidale a su farmaceutico una lista de los ingredientes. Informe a su medico si esta tomando astemizol (Hismanal) (no se vende en los EE. UU.), cisaprida (Propulsid) (no se vende en los EE. UU.), pimozida (Orap), quinidina (Quinidex) o terfenadina (Seldane) (no se vende en los EE. UU.). Es probable que su medico le indique no tomar fluconazol si esta tomando alguno de estos medicamentos. Informe a su medico y a su farmaceutico que medicamentos con y sin receta, vitaminas, suplementos nutricionales y productos herbarios esta tomando o planea tomar. Ademas, informe a su medico que ha recibido fluconazol antes de comenzar a tomar cualquier medicamento nuevo en el termino de 7 dias de recibir fluconazol. No olvide mencionar ninguno de los siguientes: amitriptilina; anfotericina B (Abelcet, AmBisome, Amphotec, Fungizone); anticoagulantes (“diluyentes de la sangre”) como warfarina (Coumadin, Jantoven); benzodiazepinas como midazolam (Versed); bloqueadores de los canales de calcio, como amlodipina (Norvasc, en Caduet, en Lotrel), felodipina (Plendil, en Lexxel), isradipina (DynaCirc) y nifedipina (Adalat, Procardia); carbamazepina (Carbatrol, Epitol, Tegretol); celecoxib (Celebrex); medicamentos reductores del colesterol (estatinas), como atorvastatina (Lipitor, en Caduet), fluvastatina (Lescol) y simvastatina (Zocor, en Simcor, en Vytorin); clopidogrel (Plavix); ciclofosfamida (Cytoxan); ciclosporina (Gengraf, Neoral, Sandimmune); diureticos (“pastillas contra la retencion de agua”) como hidroclorotiazida (HydroDIURIL, Microzide); eritromicina (E. E.S. E-Mycin, Erythrocin); fentanilo (Actiq, Duragesic, Fentora, Sublimaze); isoniazida (INH, Nydrazid); losartan (Cozaar, en Hyzaar); metadona (Methadose); nevirapina (Viramune); medicamentos antiinflamatorios no esteroides (NSAID, por sus siglas en ingles) como ibuprofeno (Advil, Motrin, otros) y naproxeno (Aleve, Anaprox, Naprelan); anticonceptivos orales (pildoras anticonceptivas); medicamentos orales para la diabetes como glipizida (Glucotrol), gliburida (Diabeta, Micronase, Glycron, otros) y tolbutamida (Orinase); nortriptilina (Pamelor); fenitoina (Dilantin, Phenytek); prednisona (Sterapred); rifabutina (Mycobutin); rifampina (Rifadin, Rimactane, en Rifamate, en Rifater); saquinavir (Invirase); sirolimus (Rapamune); tacrolimus (Prograf); teofilina (Elixophyllin, Theo-24, Uniphyl, otros); triazolam (Halcion); acido valproico (Depakene, Depakote); vimblastina; vincristina; vitamina A; voriconazol (Vfend); y zidovudina (Retrovir). Es posible que su medico deba cambiar las dosis de sus medicamentos o vigilarlo de cerca por si presentara efectos secundarios. Muchos otros medicamentos tambien pueden interactuar con el fluconazol, por lo que no olvide informar a su medico sobre todos los medicamentos que esta tomando, incluso los que no aparezcan en esta lista. Informe a su medico si tiene o alguna vez ha tenido cancer; el sindrome de inmunodeficiencia adquirida (SIDA); latidos cardiacos irregulares; niveles bajos de calcio, sodio, magnesio o potasio en la sangre; afecciones hereditarias poco comunes en las que el cuerpo no puede tolerar la lactosa o la sacarosa; o enfermedad del corazon, de los rinones o del higado. Informe a su medico si esta embarazada, sobre todo si esta en los primeros 3 meses de embarazo, si planea quedar embarazada o si esta dando el pecho. Si queda embarazada mientras toma fluconazol, llame a su medico. El fluconazol puede causarle danos al feto. Si se va a realizar una cirugia, incluso una cirugia dental, informe al medico o al dentista que esta tomando fluconazol. Tenga en cuenta que el fluconazol puede provocarle mareos o convulsiones. No conduzca vehiculos ni opere maquinaria hasta que sepa como le afecta este medicamento.

?Que dieta especial debo seguir mientras tomo este medicamento? Volver al comienzo

A menos que su medico le indique lo contrario, continue con su dieta normal. ?Que tengo que hacer si me olvido de tomar una dosis? Volver al comienzo

Si olvida tomar una dosis, tomela en cuanto se acuerde. No obstante, si ya casi es hora de la dosis siguiente, deje pasar la dosis que olvido y continue con su horario de medicacion normal. No tome una dosis doble para compensar la que olvido. ?Cuales son los efectos secundarios que podria provocar este medicamento? Volver al comienzo El fluconazol puede provocar efectos secundarios. Informe a su medico si alguno de estos sintomas es intenso o no desaparece:

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dolor de estomago

cambios en la capacidad para percibir los sabores de los alimentos

Algunos efectos secundarios pueden ser graves. Si presenta alguno de los siguientes sintomas, llame a su medico de inmediato o busque tratamiento de emergencia:



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5 Obat Alergi Kulit Di Apotik, Zensoderm

Apotik Sehat - Dalam dunia medis Alergi biasa disebut juga dengan tipe 1 hipersensitivitas yang merupakan gangguan di dalam tubuh sehingga dapat membuat seseorang terkena hipersensitif dalam Imunologi pada beberapa jenis bahan yang antigenik, dimana secara umum tubuh akan mengalami reaksi yang berlebihan pada benda asing atau benda yang berbahaya. Alergi juga dapat bersumber dari beberapa jenis makanan. Kadang-kadang, seseorang yang memakan jenis makanan akan mengalami gejala alergi seperti gatal, ruam pada kulit dan bintik-bintik merah pada kulit.

Selain itu, gejala lain yang dapat mempengaruhi sering batuk, jantung berdebar cepat dan terasa sesak napas. Untuk mengatasi hal ini ada beberapa cara yang bisa dilakukan baik secra alami maupun medis, namun untuk hasil yang lebih cepat, pasien bisa menggunakan obat alergi kulit di Apotik untuk mengatasinya.

Jenis Obat Alergi Kulit di Apotik

Loratadin . Loratadin merupakan salah satu senyawa dari obat alergi kulit di apotik yang dapat menghambat produksi histamin zat di tubuh kita. Oleh karena itu, obat ini sudah dikenal sebagai antihistamin. Loratadine digunakan sebagai obat anti alergi. Loratadin tersedia dalam dua bentuk, yaitu sirup dan tablet juga, sehingga Loratadine dapat dikonsumsi baik oleh anak-anak maupun orang dewasa.

Hydrocortison . Hidrokortison asetat merupakan anti alergi dan antipruritus pada penyakit kulit. Dalam setiap gram krim mengandung hidrokortison asetat hidrokortison setara 28 mg 25 mg yang dapat menekan peradangan pada kulit yang bukan dikarenakan oleh infeksi seperti eksim dan alergi kulit seperti: atropik dermatitis, dermatitis kontak, dermatitis alergik, pruritus dan neuro anogenital infeksi kulit.

Deksametason Harsen . Deksametason adalah obat inflamasi Harsen dan juga obat anti alergi yang sangat kuat. Sebagai perbandingan Dexamethasone 0,75 mg setara dengan obat: 25 mg Cortisone, hidrokortison 20 mg, 5 mg prednisone, prednisolon 5 mg. Dexamethasone Harsen praktis dan tidak memiliki aktivitas kortikoid mineral dari Cortisone. Obat ini digunakan sebagai anti-inflamasi terutama untuk pengobatan glukokortikoid rheumatik penyakit lainnya seperti kolagen dan arthritis, dermatitis alergi serta penyakit kulit lainnya, penyakit inflamasi pada waktu dan kondisi lain di mana terapi glucocortcoid lebih berguna untuk limfoma tertentu dan penyakit leukemia dan peradangan dalam jaringan lunak dan hemolytica.

Alleron . Dalam setiap tablet Alleron mengandung Chlorpeniramini maleas (CTM) 4 mg yang dapat mengatasi rhinitis alergi, konjungtivitas alergi, urtikaria (gatal-gatal, Buran), gatal-gatal karena gigitan serangga, eksim alergi dan alergi dermatitis.

Zensoderm Cream . Zensoderm Cream merupakan obat alergi kulit di apotik yang berfungsi sebagai dermatosis inflamasi dengan komplikasi infeksi sekunder responsif terhadap terapi kortikosteroid dan peka terhadap Gentamisin, gunakan obat ini 2 sampai 3 kali sehari ketika Anda mengalami alergi pada kulit.

Rekomendasi:

5 Nama Obat Gatal Kulit di Apotik

15 Cara Mengobati Gatal Pada Kulit Tangan Dan Kaki

Perhatian: Informasi yang ditulis didalam artikel ini bukanlah resep atau nasihat medis!



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Vlo - News And Analysis - Valero Energy Corporation, Volero

Valero Energy Corp. engages in the provision of gas and fuel. Its activities include manufacture, and distribution of conventional gasoline. diesel, petrochemicals, and other refined products. It operates through the Refining, and Ethanol segments. The Refining segment refers to the sales of refined products through wholesale rack and bulk markets in the United States, Canada, United Kingdom, and other countries. The Ethanol segment refers to the production and distribution of ethanol products among refiners and gasoline blenders under term and spot contracts; as well as in bulk markets such as New York, Chicago, United States, Gulf Coast, Florida, and the United States West Coasts. The company was founded on January 1, 1980 and is headquartered in San Antonio, TX.

Sector: Basic Materials

Industry: Oil & Gas Refining & Marketing

Country: United States

Saudi Arabia seeks to expand U. S. operations amid uneasy relations with U. S.

SA Editor Carl Surran

• SA Editor Carl Surran

Saudi Arabia is seeking to strengthen its U. S. market position by buying LyondellBasell's (LYB -1.9% ) big oil refinery in the Houston Ship Channel, but negotiations take place as Congress is moving to allow families of victims of the 9-11 attacks to sue Saudi Arabia for supposed ties between government officials and the terrorists, NY Times reports.

Saudi Aramco is believed to be the top contender for the refinery, with competition from Valero (VLO -0.9% ), Suncor (SU -2.4% ) and Cenovus (CVE -4.7% ).

The possible purchase comes as Saudi Aramco and Royal Dutch Shell are disbanding their Gulf of Mexico partnership, with the Saudis poised to gain control over the Port Arthur, Tex. refinery as well as some gasoline stations and storage facilities, while Shell will take over two smaller refineries in Louisiana that were jointly owned; Middle East oil experts say the loss of the two refineries would make the acquisition of the LYB refinery all the more vital in maintaining the Saudi's dominant market position along the Gulf coast.

Valero Energy Corporation (VLO )

Form 8-K | Filed: September 12, 2016

Refiners: Acquire Renewable Energy Group To Turn RIN Lemons Into Lemonade

08/29/16 • Viking Analytics

Refiners face a regulatory gauntlet, and RINs have become their highest operating expense.

Refiners that make ethanol can be trapped - knee deep in a river of RINs and dying of thirst.

Unlike ethanol producers, biodiesel producers have an ability to separate and control RINs.

REGI creates enough RINs to satisfy the obligation of many refiners.

The company is currently trading at less than 50% of its replacement value.

Chevron Swap Trade Successful. My Next Move? Adding Valero

08/29/16 • Cory Cramer

In June, I presented an idea to Chevron owners of a way they could increase their shares by 25%.

I argued that swapping Chevron stock for Twin Disc and holding some cash to pay oneself a dividend had an asymmetrical reward probability.

Over the last two months the spread between Twin Disc and Chevron had widened to over 30%, which was the target spread for the swap trade.

If one still finds Chevron a long term hold, they can swap back into Chevron, but I present what I think is a better alternative.

Reuters: LyondellBasell considering sale of Houston refinery

08/25/16 • SA Editor Carl Surran

• SA Editor Carl Surran

LyondellBasell (NYSE:LYB ) has retained Bank of America Merrill Lynch to help with the potential sale of its 263K bbl/day refinery in Houston, Reuters reports.

Saudi Aramco, Valero Energy (NYSE:VLO ), Cenovus Energy (NYSE:CVE ) and Suncor Energy (NYSE:SU ) are among the companies that have expressed interest, according to the report.

LYB CEO Bob Patel said earlier this year that he expected the refinery eventually would go on sale, but he has not offered any time frame.

Valero: Wait For A Better Entry Point

08/25/16 • Aristofanis Papadatos

The analysts have revised downwards their estimates for the earnings of Valero several times in the last 3 months.

The refining sector seems to be in the early stages of its down cycle.

US refiners will never enjoy the refining margins of the recent past due to the lift of the ban of crude oil exports.

The Market Got Valero All Wrong

08/23/16 • Paulo Santos

Valero has behaved as expected, with its stock underperforming and EPS consensus collapsing.

Yet, even with Valero doing so badly, the market is still wrong about it.

This article explains what the market's error is, and what it implies.

Is Valero's High Dividend Yield Safe? A Comprehensive Review

08/23/16 • Simply Safe Dividends

• Simply Safe Dividends

Valero's stock offers a 4.4% dividend yield, but the company's earnings recently fell over 50%. Valero also cut its dividend in 2010. Is the current payout sustainable?

The refining industry has been one of the only bright spots in the energy sector, but its margins have begun to compress. Learn the ins and outs of the industry.

Should conservative dividend investors buy Valero today? After slumping over 20% year-to-date, the stock looks very reasonably priced.

Valero Energy Partners buys terminal service assets in $325M drop-down

08/22/16 • SA Editor Carl Surran

• SA Editor Carl Surran

Valero Energy Partners (NYSE:VLP ) agrees to acquire terminals at two refineries in Louisiana and Texas from Valero Energy (NYSE:VLO ) for $325M.

The Meraux, La. assets have 3.9M barrels of storage capacity for crude oil, intermediates and refined petroleum products, while the Three Rivers, Tex. terminal has 2.25M barrels of capacity.

VLP expects the acquisition to add

$25M of net income and $39M of EBITDA during the first year of operation.

Valero Energy Targets Competitive Dividend

Valero is the world's largest independent refiner, and it is also one of North America's largest renewable fuels producers.

Having more than 55% of its throughput capacity in the US Gulf Coast region gives Valero Energy some key advantages.

Let's take a look at the firm's investment highlights as we walk through the valuation process and derive a fair value estimate for shares.

Icahn urges change to renewable fuel credit system

08/16/16 • SA Editor Yoel Minkoff

• SA Editor Yoel Minkoff

Billionaire investor Carl Icahn has called on the EPA to make changes to the market for renewable fuel credits or else risk "the mother of all short squeezes" that could bankrupt refiners.

"The RIN market is the quintessential example of a 'rigged' market where large gas station chains, big oil companies and large speculators are assured to make windfall profits at the expense of small and midsized independent refineries which have been designated the 'obligated parties' to deliver RINs."

Related tickers: VLO. NTI. CLMT. MPC. TSO. ALDW. CVI. WNR. PBF. DK. HFC. CVRR. NTI. ALJ. TSO. WNR. PSX. XOM. PBF

Reuters: Refiners on track to spend record on U. S. clean fuel standards

08/11/16 • SA Editor Carl Surran

• SA Editor Carl Surran

Major U. S. refiners are on track to pay record amounts this year for credits to comply with U. S. renewable fuel rules, a trend that is bound to continue to hurt profits for the group, Reuters reports.

A group of 10 refinery owners including Marathon Petroleum (NYSE:MPC ) and Valero Energy (NYSE:VLO ) spent at least $1.1B buying RINs, according to a Reuters review of their filings, placing them on track to surpass the annual record of $1.3B spent by the same group in 2013.

RINs averaged

$0.78 each during Q2,

25% above the same period a year ago, according to the analysis, due to more ambitious targets from U. S. regulators on the volumes of ethanol required to be blended with gasoline.

Other relevant tickers include PBF. CVRR. HFC. TSO. PSX. WNR. DK .

Valero Energy Corp. A Long-Term Bargain

08/09/16 • Cash-Centered Creep

As crude oil has slumped, so too has Valero's share price.

Valero offers a high dividend yield and sustainable shareholder value.

It is cheap now, but may be cheaper still in the very near future.

Refining trade group pushes EPA to change biofuels program

08/05/16 • SA Editor Carl Surran

• SA Editor Carl Surran

The American Fuel and Petrochemical Manufacturers trade group is petitioning the EPA to change the way the agency enforces the U. S. biofuel mandate, shifting the responsibility of program compliance with distributors who blend gasoline with ethanol for delivery to filling stations, not with refiners who make the fuels.

The AFPM and other oil and gas groups have long been opposed to the Renewable Fuel Standard, which sets the amounts of biofuels such as ethanol that must be blended into U. S. gasoline and diesel supplies annually, arguing the mandates are costly for refiners and do not reflect actual gasoline demand, which has not risen as fast as lawmakers originally envisioned.

Renewable fuel credits have surged 32% in the past two months. even as crude oil prices have dropped; this year, U. S. refiners will pay $1.8B for the RIN credits, adding to the pain of the lowest summer profit margins in five years.

Relevant tickers include VLO. PBF. CVRR. HFC. REGI. PEIX. REX. GPRE

Valero Energy Corporation (VLO )

Form 10-Q | Filed: August 4, 2016

Refiners to cut production as margins shrink, Phillips 66 CEO says

07/29/16 • SA Editor Carl Surran

• SA Editor Carl Surran

Phillips 66 (NYSE:PSX ) CEO Greg Garland predicts refiners will process less crude in H2 of this year as margins shrink due to a gasoline glut.

"We've got a lot of inventory stacked up," but demand for refined products remains strong, Garland said on today earnings conference call.

PSX says its refineries will function at a mid-90% capacity in the current quarter rather than 100% utilization in Q2, in which its reported profit was sliced in half as earnings from its refining business plunged 75% Y/Y .

PSX's Q2 refining margin was $7.13/bbl, well below $8.22/bbl estimated by Wells Fargo analysts, and smaller rival Alon USA Energy (NYSE:ALJ ) reported that its Q2 refinery operating margin fell by more than half to $3.96/bbl.

Throughout the week, Valero Energy (NYSE:VLO ), Marathon Petroleum (NYSE:MPC ) and BP all reported a decline in refining margins for the period.

Valero Isn't Worried About The Gasoline Glut - Oil Markets Daily

Valero blames high utilization earlier this year for the gasoline glut.

Valero won't take into account near-term economics into its turnaround decisions.

If refineries don't slow down, that will be good for crude oil prices.

Valero Energy declares $0.60 dividend

07/28/16 • SA Editor 1

Valero Energy (NYSE:VLO ) declares $0.60/share quarterly dividend. in line with previous.

Forward yield 4.63%

Payable Sept. 8; for shareholders of record Aug. 11; ex-div Aug. 9.

Should You Buy Valero Energy Following Earnings?

07/26/16 • Gold Mining Bull

• Gold Mining Bull

Valero Energy has reported its Q2 2016 financial results.

The company smashed my earnings expectations as it reported net income of $1.07 per share and generated $2.3 billion in operating cash flow.

Valero also said it bought back 7.5 million common shares of stock in Q2 for $401 million.

I break down the Q2 earnings and give my thoughts on the stock here.

Valero Energy (VLO) Joseph W. Gorder on Q2 2016 Results - Earnings Call Transcript

07/26/16 • SA Transcripts

Valero sees lower refinery utilization as margins slump

07/26/16 • SA Editor Carl Surran

• SA Editor Carl Surran

Valero Energy (VLO +4.6% ) is higher after Q2 earnings and revenues both beat analyst expectations and the refiner exported a Q2 record 396K bbl/day of diesel and gasoline combined.

The glut in refined products pushed down VLO's Q2 refining throughput margin to $8.93/bbl from $13.71/bbl a year ago, as combined Q2 throughput of 2.83M bbl/day at the company's 15 refineries is expected to fall slightly to 2.79M bbl/day in Q3; VLO says it expects 94% capacity utilization at its refineries in Q3, unchanged from Q2.

VLO says Q2 biofuel blending costs more than tripled to $173M from $56M a year ago, primarily due to the purchase of RIN credits, and continues to expect blending costs this year of $750M-$850M from $440M in 2015.

RIN prices have been rising since regulators set annual targets in May for the amount of biofuels including ethanol required to blend with gasoline and diesel amid increased worries over tightening inventories; elevated costs for RINs credits are one of VLO's major headwinds, investor relations VP John Locke said today's earnings conference call.

Valero Energy beats by $0.04, beats on revenue

07/26/16 • SA Editor Gaurav Batavia

• SA Editor Gaurav Batavia



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Controloc Control 20 Mg Gastro-Resistant Tablets, Controloc

CONTROLOC Control 20 mg gastro-resistant tablets

CONTROLOC Control contains the active substance pantoprazole, which blocks the ‘pump’ that produces stomach acid. Hence it reduces the amount of acid in your stomach.

CONTROLOC Control is used for the short-term treatment of reflux symptoms (for example heartburn, acid regurgitation) in adults. Reflux is the backflow of acid from the stomach into the gullet (“foodpipe”), which may become inflamed and painful. This may cause you symptoms such as a painful burning sensation in the chest rising up to the throat (heartburn) and a sour taste in the mouth (acid regurgitation).

You may experience relief from your acid reflux and heartburn symptoms after just one day of treatment with CONTROLOC Control, but this medicine is not meant to bring immediate relief. It may be necessary to take the tablets for 2-3 consecutive days to relieve the symptoms.

Do not take CONTROLOC Control:

if you are allergic (hypersensitive) to pantoprazole, to soya or to any of the other ingredients of CONTROLOC Control (listed insection 6 ‘What CONTROLOC Control contains’).

if you are taking a medicine containing atazanavir (for the treatment of HIV-infection)

if you are under 18 years of age

if you are pregnant or breast-feeding.

Take special care with CONTROLOC Control Talk to your doctor first if:

you have been treated for heartburn or indigestion continuously for 4 or more weeks

you are over 55 years old and taking non-prescription indigestion treatment on a daily basis

you are over 55 years old with new or recently changed symptoms

you have previously had a gastric ulcer or stomach surgery

you have liver problems or jaundice (yellowing of skin or eyes)

you regularly see your doctor for serious complaints or conditions

you are due to have an endoscopy or a breath test called a C-urea test.

Tell your doctor immediately . before or after taking this medicine, if you notice any of the following symptoms, which could be a sign of another, more serious, disease:

an unintentional loss of weight (not related to a diet or an exercise programme)

vomiting, particularly if repeated

vomiting blood; this may appear as dark coffee grounds in your vomit

you notice blood in your stools; which may be black or tarry in appearance

difficulty in swallowing or pain when swallowing

you look pale and feel weak (anaemia)

chest pain

stomach pain

severe and/or persistent diarrhoea, because CONTROLOC Control has been associated with a small increase in infectious diarrhoea. Your doctor may decide that you need some tests.

If you are due to have a blood test, tell your doctor that you are taking this medicine.

You may experience relief from your acid reflux and heartburn symptoms after just one day of treatment with CONTROLOC Control, but this medicine is not meant to bring immediate relief. You should not take it as a preventive measure.

If you have been suffering from repetitive heartburn or indigestion symptoms for some time, remember to see your doctor regularly.

Using other medicines CONTROLOC Control may stop certain other medicines from working properly. Tell yourdoctor or pharmacist if you are using anymedicines containing one of the following active substances:

ketoconazole (used for fungal infections).

warfarin and phenprocoumon(used to thin blood and prevent clots). You may need further blood tests

atazanavir (used to treat HIV-infection). You must not use CONTROLOC Control if you are taking atazanavir.

Do not take CONTROLOC Control with other medicines which limit the amount of acid produced in your stomach, such as another proton pump inhibitor (omeprazole, lansoprazole or rabeprazole) or an H2 antagonist (e. g. ranitidine, famotidine). However, you may take CONTROLOC Control with antacids (e. g. magaldrate, alginic acid, sodium bicarbonate, aluminium hydroxide, magnesium carbonate, or combinations thereof), if needed.

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. This alsoincludes herbal or homeopathic remedies.

Using CONTROLOC Control with food and drink The tablets should be swallowed whole with liquid before a meal.

Pregnancy and breast-feeding Do not take CONTROLOC Control if you are pregnant, think you may be pregnant, or are breast-feeding. Ask your doctor or pharmacist for advice before taking any medicine.

Driving and using machines If you experience side effects like dizziness or disturbed vision, you should not drive or operate machines.

Important information about some of the ingredients of CONTROLOC Control CONTROLOC Control contains soya lecithin. If you are allergic to peanut or soya, do not use this medicine.

Always take CONTROLOC Control exactly as described in this leaflet. You should check with your doctor orpharmacist if you are not sure.

Take one tablet a day. Do not exceed this recommended dose of 20 mg pantoprazole daily.

You should take this medicine for at least 2-3 consecutive days. Stop taking CONTROLOC Control when you are completely symptom-free. You may experience relief from your acid reflux and heartburn symptoms after just one day of treatment with CONTROLOC Control, but this medicine is not meant to bring immediate relief.

If you have no symptom-relief after taking this medicine for 2 weeks continuously, consult your doctor. Do not take CONTROLOC Control tablets for more than 4 weeks without consulting your doctor.

Take the tablet before a meal, at the same time every day. You should swallow the tablet whole with some water. Do not chew or break the tablet.

Children and adolescents CONTROLOC Control should not be used by children and young people under 18 years of age.

If you take more CONTROLOC Control than you should Tell your doctor or pharmacist straight away. If possible take your medicine and this leaflet with you. There are no known symptoms of overdose.

If you forget to take CONTROLOC Control Do not take a double dose to make up for the forgotten dose. Take your next, normal dose, the next day, at your usual time.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Like all medicines, CONTROLOC Control can cause side effects, although not everybody gets them.

Tell your doctor immediately or contact the casualty department at your nearest hospital, if you get any of the following serious side effects . Stop taking this medicine straight away, but take this leaflet and/or the tablets with you.

Serious allergic reactions (rare) . Hypersensitivity reactions, so-called anaphylactic reactions, anaphylactic shock and angioedema. Typical symptoms are: swelling of the face, lips, mouth, tongue and/or throat, which may cause difficulty in swallowing or breathing, hives (nettle rash), severe dizziness with very fast heartbeat and heavy sweating.

Serious skin reactions (frequency not known) . rash with swelling, blistering or peeling of the skin, losing skin and bleeding around eyes, nose, mouth or genitals and rapid deterioration of your general health, or rash when exposed to the sun.

Other serious reactions (frequency not known) :yellowing of the skin and eyes (due to severe liver damage), or kidney problems such as painful urination and lower back pain with fever.

Side effects may occur with certain frequencies, which are defined as follows:

very common: affects more than 1 user in 10 common: affects 1 to 10 users in 100 uncommon: affects 1 to 10 users in 1,000 rare: affects 1 to 10 users in 10,000 very rare: affects less than 1 user in 10,000 not known: frequency cannot be estimated from the available data.

Uncommon side effects . headache; dizziness; diarrhoea; feeling sick, vomiting; bloating and flatulence (wind); constipation; dry mouth; bellyache and discomfort; skin rash or hives; itching; feeling weak, exhausted or generally unwell; sleep disorders; increase in liver enzymes in a blood test.

Rare side effects . disturbances in vision such as blurred vision; pain in the joints; muscle pains; weight changes; raised body temperature; swelling of the extremities; allergic reactions; depression; increased bilirubin and fat levels in blood (seen in blood tests).

Very rare side effects . disorientation; reduction in the number of blood platelets, which may cause you to bleed or bruise more than normal; reduction in the number of white blood cells, which may lead to more frequent infections.

Frequency not known :hallucination, confusion (especially in patients with a history of these symptoms); decreased level of sodium in blood.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

Keep out of the reach and sight of children.

Do not use CONTROLOC Control after the expiry date, which isstated on the carton and the blister. The expiry date refers to the last day of that month.

Store in the original package in order to protect from moisture .

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.



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Rabeprazole Indications, Side Effects, Warnings, Rabeprazolum

Rabeprazole

Rabeprazole is used for:

Treating heartburn or irritation of the esophagus caused by gastroesophageal reflux disease (GERD). It may be used for short-term treatment of ulcers of the small intestine. It may be used with certain antibiotics to treat ulcers of the small intestine and to help prevent them from coming back. It may be used to treat conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It may also be used for other conditions as determined by your doctor.

Rabeprazole is a proton pump inhibitor. It works by decreasing the amount of acid produced in the stomach.

Do NOT use rabeprazole if:

you are allergic to any ingredient in rabeprazole or to similar medicines (eg, omeprazole)

you are taking atazanavir, dasatinib, erlotinib, or rilpivirine

Contact your doctor or health care provider right away if any of these apply to you.

Before using rabeprazole:

Some medical conditions may interact with rabeprazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have low blood potassium or magnesium levels, liver problems, or stomach or bowel cancer

if you have osteoporosis (weak bones), a family history of osteoporosis, or other risk factors of osteoporosis (eg, smoking, poor nutrition)

Some MEDICINES MAY INTERACT with rabeprazole. Tell your health care provider if you are taking any other medicines, especially any of the following:

Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood magnesium levels may be increased

Anticoagulants (eg, warfarin), cyclosporine, diazepam, digoxin, methotrexate, phenytoin, raltegravir, risedronate, saquinavir, theophylline, or tolterodine because the risk of their side effects may be increased by rabeprazole

Atazanavir, bosutinib, clopidogrel, dasatinib, erlotinib, indinavir, iron, itraconazole, ketoconazole, mycophenolate, nelfinavir, nilotinib, posaconazole, rilpivirine, or sorafenib because their effectiveness may be decreased by rabeprazole

This may not be a complete list of all interactions that may occur. Ask your health care provider if rabeprazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use rabeprazole:

Use rabeprazole as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Rabeprazole comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get rabeprazole refilled.

Take rabeprazole by mouth with or without food.

Swallow rabeprazole whole. Do not break, crush, or chew before swallowing.

Tell your doctor if you cannot swallow tablets whole. You may need a different medicine.

You may take antacids while you are taking rabeprazole if you are directed to do so by your doctor.

Continue to take rabeprazole even if you feel well. Do not miss any doses.

If you miss a dose of rabeprazole, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use rabeprazole.

Important safety information:

Contact your doctor if you have any symptoms of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds, or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing.

Do NOT change your dose, stop taking rabeprazole, or take rabeprazole for longer than prescribed without checking with your doctor.

Rabeprazole may increase the risk of a serious form of diarrhea. Contact your doctor right away if stomach pain or cramps, severe or persistent diarrhea, or bloody or watery stools occur. Discuss any questions or concerns with your doctor.

Rabeprazole may increase the risk of hip, wrist, and spine fractures in patients with weak bones (osteoporosis). The risk may be greater if you use rabeprazole in high doses, for long periods of time, or if you are older than 50 years old. Contact your doctor if you have any questions about this information.

Low blood magnesium levels have been reported rarely in patients taking proton pump inhibitors for at least 3 months. In most cases, this effect was seen after a year of treatment. If you will be taking rabeprazole for a long time, or if you take certain other medicines (eg, digoxin, diuretics), your doctor may perform lab tests to check for low blood magnesium levels. Seek medical attention right away if you experience symptoms of low blood magnesium levels (eg, dizziness; fast or irregular heartbeat; involuntary muscle movements; jitteriness or tremors; muscle aches, cramps, pain, spasms, or weakness; seizures).

Check with your doctor to see whether you should take a calcium and vitamin D supplement while you use rabeprazole.

Tell your doctor or dentist that you take rabeprazole before you receive any medical or dental care, emergency care, or surgery.

Use rabeprazole with caution in the ELDERLY; they may be more sensitive to its effects, especially hip, wrist, and spine fractures.

Rabeprazole should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using rabeprazole while you are pregnant. It is not known if rabeprazole is found in breast milk. Do not breast-feed while taking rabeprazole.

Possible side effects of rabeprazole:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; gas; headache; mild diarrhea; mild sore throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or watery stools; bone pain; chest pain; dizziness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; involuntary muscle movements; joint or muscle aches or pain; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea, nausea, or vomiting; severe or persistent stomach or back pain; stomach cramps; swelling of the hands, ankles, or feet; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, unusual nausea, yellowing of the skin or eyes); tremors; unexplained weight loss; unusual bruising or bleeding; unusual tiredness or weakness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately.

Proper storage of rabeprazole:

Store rabeprazole at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep rabeprazole out of the reach of children and away from pets.

General information:

If you have any questions about rabeprazole, please talk with your doctor, pharmacist, or other health care provider.

Rabeprazole is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take rabeprazole or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about rabeprazole. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to rabeprazole. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using rabeprazole.

Review Date: August 8, 2016

Database Edition 13.4.1.001

Copyright © 2013 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.



Buy Online Rabeprazole Indications, Side Effects, Warnings, Rabeprazolum

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stufff kirjoitti: Ainut kaveri joka noita soi ampu ittensa. Taa tieto varmaa auttaaki paljo.

Kyl kyl, aivan helvetisti.

Joo, ehka ma jatan ne ottamatta tai sit puolitan ja puolitan ja ja ja.

En tieda onko noi millaan muotoo verrattavissa siihen Seroqueliin. Kun siita meni ihan sekaisin kun otti nii vahvan et jos toi sit tekee saman. Jaa-a.

hopohopo, siita sekasin mene se pistaa vaa vahan vasyttaa. Tutulla meni sita 1600mg paivaan. Ite soin n.1v 150-200mg iltaan. Se vaan vasyttaa.

"nyt tennarit jalkaan ja unta palloon"

"anteeksi, saatte pitaa tyhmana mutta miksi ihmeessa niin moni narkomaani nukkuu lenkkarit jalassa?"

Viirus Vahvasti panostava jasen Viestit: 531 Liittynyt: 19.9.2005 07:31:19

Ei kai mua muuten huoleta, mutta, mulla ei ole maniaa eika epilepsiaa, noi laakkeet ei ole mulle tarkoitettu, niita nyt vaan sattuneesta syysta pyorii nurkissa.

"Faster, faster, until the thrill of speed overcomes the fear of death." - Hunter S. Thompson -

Lamb Vahvasti panostava jasen Viestit: 641 Liittynyt: 3.12.2005 19:44:22

Se on yks lukuisista laakkeista, jotka jatin itse suosiolla, sitten kerroin lekurille. Oli mjuitakin, suljetulla antoivat, ja sitte A-klinikka jatkoi. Ja mina lopetin.

ceepos Vahvasti panostava jasen Viestit: 125 Liittynyt: 14.6.2007 10:44:58 Paikkakunta: Helsinki

Vastaus tulee ehka huonosti ajoitettuna, mutta henkilokohtaisella tasolla kyseisesta laakkeesta ei ole mielestani minkaan vertaa mitaan iloa. (Ihan laakarin maaraamana sain, ensimmainen minka aloitin) Laakkeen kayton aluksi helvetinmoinen vasymys, kiinnostus tehda asioita tai yhtaan mitaan sen puoleen tasan nolla, hengastyy rappusia kavellessa, tulee muutenkin yleistypera olo. Paivan kohokohta oli jos jaksoi kavella kauppaan (sijaitsee 50 metrin paassa). Saattaa ehka jollain tasolla lievittaa jotain "angsteja" mutta laakkeen todellinen vaikutusaika (se etta tulee hyva fiilis, tai lahinna se etta ei tule mitaan fiilista) on noin kuukauden verran. Edes isompi annos ei tuottanut mun kokoisella kevytrakenteisella naisella mitaan efektia. Itse vaihdoin Seroqueliin valitettuani zombie-olosta. Kotona odottaa avaamaton satsi kyseista tuotetta, en halua koskea niihin pitkalla tikullakaan. Sokerihumalakin tuottaa enemman iloa.

P. S Paino nousee myos molempien laakkeiden kohdalla.

Beratta for mig hur man bryter isen?

Isola Miedosti panostava jasen Viestit: 38 Liittynyt: 22.5.2007 18:29:27 Paikkakunta: Helsinki

Just, totaalinen tylsistyminen, mulla oli sen rinnalla jotakin, en muista enaa. Makasin vaan kuin lamaantuneena, sitte yks kusipaa viela aina muka auttoi mua, ku olin depiksessa. Olisin vaikka jotakin toimittanu siina, mutta lisas sita peiton alle piiloutumista ku joku esittaa pomoa mun kotonani. (Sama joka sittemmin pariin krt pah. piteli mut, no, se on puolvihanneksena, sai se tuomion silti) Taas OT-ei juma nyt on vasattava vedot, sit asioille.

Vaikka moniin laakkeisiin on mulla valtava tole, tai ei vaan toimi edes norm kaytossa, niin toi Deprakine mm. oli niita aivan kasittamattomia, tulee mieleen potilaan jostaki mielisairaalaleffasta.

ceepos Vahvasti panostava jasen Viestit: 125 Liittynyt: 14.6.2007 10:44:58 Paikkakunta: Helsinki

Mulle maaratty 600mg paivassa juuri epilepsiaan. En kylla oo niita syonyt, kun mielestani on aivan yksi ja sama syonko niita vai en. Ja eivat ole Seroqueleihin verrattavissa. Itella serquja nukahtamiseen, deprakinesta tuu yhtaan mitaan. Sama kuin kalkkitabuja soisi.

Flow Vahvasti panostava jasen Viestit: 659 Liittynyt: 16.1.2006 12:31:19

Mulla ei ole paino noussut eika ruokahalu lisaantynyt yhtaan vaan enemminkin paino pudonnut jonkun verran. Mulla ei myoskaan tullu mitaan zombie oloa ja oon kylla jaksanut treenata ja kayda lenkilla entiseen malliin. Ainut mista jotain huomaan on etta nukun yolla sikeammin ja se hypomaaninen olo on pois. Noi on niin yksilollisia noi sivuoireet.

ahis Vahvasti panostava jasen Viestit: 1428 Liittynyt: 7.8.2006 11:52:33



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Coumadin (Warfarin Sodium) Side Effects, Interactions, Warning, Dosage & Uses, Coumadine

COUMADIN can cause major or fatal bleeding [see WARNINGS AND PRECAUTIONS ].

Perform regular monitoring of INR in all treated patients [see DOSAGE AND ADMINISTRATION ].

Drugs, dietary changes, and other factors affect INR levels achieved with COUMADIN therapy [see DRUG INTERACTIONS ].

Instruct patients about prevention measures to minimize risk of bleeding and to report signs and symptoms of bleeding [see PATIENT INFORMATION ].

DRUG DESCRIPTION

COUMADIN (warfarin sodium) tablets and COUMADIN (warfarin sodium) for injection contain warfarin sodium, an anticoagulant that acts by inhibiting vitamin K - dependent coagulation factors. The chemical name of warfarin sodium is 3-(α-acetonylbenzyl)-4- hydroxycoumarin sodium salt, which is a racemic mixture of the R - and S-enantiomers. Crystalline warfarin sodium is an isopropanol clathrate. Its empirical formula is C 19 H 15 NaO 4 . and its structural formula is represented by the following:

Crystalline warfarin sodium occurs as a white, odorless, crystalline powder that is discolored by light. It is very soluble in water, freely soluble in alcohol, and very slightly soluble in chloroform and ether.

COUMADIN tablets for oral use also contain:

All strengths: Lactose, starch, and magnesium stearate 1 mg: D&C Red No. 6 Barium Lake 2 mg: FD&C Blue No. 2 Aluminum Lake and FD&C Red No. 40 Aluminum Lake 2-1/2 mg: D&C Yellow No. 10 Aluminum Lake and FD&C Blue No. 1 Aluminum Lake 3 mg: FD&C Yellow No. 6 Aluminum Lake, FD&C Blue No. 2 Aluminum Lake, and FD&C Red No. 40 Aluminum Lake 4 mg: FD&C Blue No. 1 Aluminum Lake 5 mg: FD&C Yellow No. 6 Aluminum Lake 6 mg: FD&C Yellow No. 6 Aluminum Lake and FD&C Blue No. 1 Aluminum Lake 7-1/2 mg: D&C Yellow No. 10 Aluminum Lake and FD&C Yellow No. 6 Aluminum Lake 10 mg: Dye-free

COUMADIN for injection for intravenous use is supplied as a sterile, lyophilized powder, which, after reconstitution with 2.7 mL Sterile Water for Injection, contains:

Warfarin sodium 2 mg per mL Sodium phosphate, dibasic, heptahydrate 4.98 mg per mL Sodium phosphate, monobasic, monohydrate 0.194 mg per mL Sodium chloride 0.1 mg per mL Mannitol 38.0 mg per mL Sodium hydroxide, as needed for pH adjustment to 8.1 to 8.3

What are the possible side effects of warfarin (Coumadin, Jantoven)?

Get emergency medical help if you have any of these signs of an allergic reaction . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using warfarin and call your doctor at once if you have a serious side effect such as:

pain, swelling, hot or cold feeling, skin changes, or discoloration anywhere on your body;

sudden and severe leg or foot pain, foot ulcer, purple toes or fingers;

sudden headache, dizziness, or weakness;

unusual bleeding (nose, mouth, vagina, or rectum), bleeding from wounds or needle.

What are the precautions when taking warfarin sodium (Coumadin)?

Before taking warfarin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood disorders (such as anemia, hemophilia), bleeding problems (such as bleeding of the stomach/intestines, bleeding in the brain), blood vessel disorders (such as aneurysms), recent major injury/surgery, liver disease, alcohol use, mental/mood disorders (including memory problems), frequent falls/injuries.

It is important that all your doctors and dentists know that you take warfarin. Before having surgery or any.

Last reviewed on RxList: 1/8/2016 This monograph has been modified to include the generic and brand name in many instances.



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Lipitor - Cholesterol Lowering, Atorpharm

Common use Atorvastatin is a cholesterol-lowering used to treat high cholesterol or to lower the risk of stroke, heart attack or other heart complications in patients with coronary heart disease or second type of diabetes. Atorvastatin helps to clear harmful low-density lipoprotein cholesterol out of the blood and by limiting the body's ability to form new LDL cholesterol. Thus it can help prevent hardening of the arteries and heart disease, conditions that can lead to vascular disease, heart attack, stroke.

Dosage and direction Take it orally once a day with or without food. Atorvastatine should be taken with full glass of water. The common dose for adults is 10 mg once daily. The common dose for children from 10 to 17 years of age is 10 mg once daily. Using Atorvastatin in children less than 10 years of age is not recommended and dose must be determined by your family doctor.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.

Precautions People with diabetes, underactive thyroid glands, kidney disease, or muscle disease sometimes need additional tests before or during atorvastatin therapy since dosage adjustments may be required. Do not use large amounts of alcohol while taking this drug because it can worsen the adverse effects of this medicine on the liver. Atorvastatin should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use Atorvastatin before breast-feeding without doctor's permission.

Contraindications Atorvastatin is not allowed to people who have liver problems or unexplained abnormal liver function tests. Do not use it if you are taking an HIV protease inhibitor (eg, ritonavir), itraconazole, or mibefradil. Also Atorvastatin contraindicated if you are hypersensitive to any components of this medication, pregnancy or breast-feeding.

Possible side effect They may include all types of an allergic reaction. Also the most possible side effects include: muscle pain, tenderness, or weakness with fever or flu symptoms; or nausea, clay-colored stools, stomach pain, low fever, jaundice, loss of appetite, dark urine. Less serious include: mild nausea or stomach pain, stomach upset, heartburn; constipation, bloating, gas; stuffy nose; itching, skin rash; headache. If you experience one of them stop using Atorvastatin and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Atrovastatin interact with the following drugs: digoxin; erythromycin or clarithromycin; gemfibrozil or fenofibrate; niacin; an antifungal medication such as itraconazole, fluconazole, or ketoconazole; drugs that weaken your immune system such as cancer medicine or steroids, cyclosporine, sirolimus, tacrolimus, and others; HIV or AIDS medication such as indinavir, nelfinavir, ritonavir, lopinavir-ritonavir, or saquinavir. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Symptoms of Atorvastatin are not known well but most possible of them include a severe drop in blood pressure and a faster heartbeat. If you experience one of them or any unusual symptoms, call your doctor immediately.

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use Atorvastatin is a cholesterol-lowering used to treat high cholesterol or to lower the risk of stroke, heart attack or other heart complications in patients with coronary heart disease or second type of diabetes. Atorvastatin helps to clear harmful low-density lipoprotein cholesterol out of the blood and by limiting the body's ability to form new LDL cholesterol. Thus it can help prevent hardening of the arteries and heart disease, conditions that can lead to vascular disease, heart attack, stroke.

Dosage and direction Take it orally once a day with or without food. Atorvastatine should be taken with full glass of water. The common dose for adults is 10 mg once daily. The common dose for children from 10 to 17 years of age is 10 mg once daily. Using Atorvastatin in children less than 10 years of age is not recommended and dose must be determined by your family doctor.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.

Precautions People with diabetes, underactive thyroid glands, kidney disease, or muscle disease sometimes need additional tests before or during atorvastatin therapy since dosage adjustments may be required. Do not use large amounts of alcohol while taking this drug because it can worsen the adverse effects of this medicine on the liver. Atorvastatin should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use Atorvastatin before breast-feeding without doctor's permission.

Contraindications Atorvastatin is not allowed to people who have liver problems or unexplained abnormal liver function tests. Do not use it if you are taking an HIV protease inhibitor (eg, ritonavir), itraconazole, or mibefradil. Also Atorvastatin contraindicated if you are hypersensitive to any components of this medication, pregnancy or breast-feeding.

Possible side effect They may include all types of an allergic reaction. Also the most possible side effects include: muscle pain, tenderness, or weakness with fever or flu symptoms; or nausea, clay-colored stools, stomach pain, low fever, jaundice, loss of appetite, dark urine. Less serious include: mild nausea or stomach pain, stomach upset, heartburn; constipation, bloating, gas; stuffy nose; itching, skin rash; headache. If you experience one of them stop using Atorvastatin and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Atrovastatin interact with the following drugs: digoxin; erythromycin or clarithromycin; gemfibrozil or fenofibrate; niacin; an antifungal medication such as itraconazole, fluconazole, or ketoconazole; drugs that weaken your immune system such as cancer medicine or steroids, cyclosporine, sirolimus, tacrolimus, and others; HIV or AIDS medication such as indinavir, nelfinavir, ritonavir, lopinavir-ritonavir, or saquinavir. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Symptoms of Atorvastatin are not known well but most possible of them include a severe drop in blood pressure and a faster heartbeat. If you experience one of them or any unusual symptoms, call your doctor immediately.

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.



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Nifedipine, Adalat, Procardia Drug Side Effects & Dosing, Nifedine

nifedipine, Adalat (discontinued brand), Procardia, Afeditab, Nifediac

Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

William C. Shiel Jr. MD, FACP, FACR

Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Quick Guide How to Lower Blood Pressure: Exercise Tips (Pictures)



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Hydrochlorothiazide - Blood Pressure, Labodrex

Blood Pressure - Labodrex (Brand name: hydrochlorothiazide)

Hydrochlorothiazide is used for treating high blood pressure. It is also used to treat fluid buildup in the body caused by certain conditions (e. g. heart failure, liver cirrhosis, kidney problems) or medicines (e. g. corticosteroids, estrogen). It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Use Hydrochlorothiazide as directed by your doctor.

Take Hydrochlorothiazide by mouth with or without food. Hydrochlorothiazide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm. Ask your health care provider any questions you may have about how to use Hydrochlorothiazide. Drug Class and Mechanism

Hydrochlorothiazide is a thiazide diuretic. It helps the kidneys to remove fluid from the body.

If you miss a dose of Hydrochlorothiazide and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Hydrochlorothiazide between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hydrochlorothiazide out of the reach of children and away from pets.

Do not use Hydrochlorothiazide if:

you are allergic to any ingredient in Hydrochlorothiazide; you are unable to urinate; you are taking dofetilide or ketanserin. Contact your doctor or health care provider right away if any of these apply to you.

Important : Hydrochlorothiazide may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Hydrochlorothiazide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Hydrochlorothiazide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Your doctor may also prescribe a potassium supplement for you. If so, take the potassium supplement exactly as prescribed. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor. Tell your doctor or dentist that you take Hydrochlorothiazide before you receive any medical or dental care, emergency care, or surgery. Tell your doctor if you will be exposed to high temperatures. The risk of certain side effects (eg, low blood sodium levels) may be increased in hot weather. Hydrochlorothiazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Hydrochlorothiazide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. Hydrochlorothiazide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away. Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Lab tests, including kidney function, blood pressure, and electrolyte levels, may be performed while you use Hydrochlorothiazide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Pregnancy and breast-feeding: Hydrochlorothiazide may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hydrochlorothiazide while you are pregnant. Hydrochlorothiazide is found in breast milk. If you are or will be breast-feeding while you use Hydrochlorothiazide, check with your doctor. Discuss any possible risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; lightheadedness (especially when sitting up or standing); loss of appetite; nausea; temporary blurred vision. Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dark urine; decreased urination; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; increased thirst; joint pain, swelling, warmth, or redness (especially of the big toe joint); mental or mood changes; muscle pain or cramps; numbness or tingling; red, swollen, blistered, or peeling skin; seizures; severe or persistent dizziness; severe or persistent nausea or stomach pain; shortness of breath; unusual bruising or bleeding; unusual drowsiness, restlessness, tiredness, or weakness; unusually dry mouth; vomiting; yellowing of the eyes or skin.

If you have any questions about Hydrochlorothiazide, please talk with your doctor, pharmacist, or other health care provider. Hydrochlorothiazide is to be used only by the patient for whom it is prescribed. Do not share it with other people.



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Myogesic Drug Interactions, Myogesic

Myogesic (magnesium salicylate / phenyltoloxamine) Drug Interactions

A total of 962 drugs (5271 brand and generic names) are known to interact with Myogesic (magnesium salicylate / phenyltoloxamine) .

65 major drug interactions (303 brand and generic names)

852 moderate drug interactions (4807 brand and generic names)

45 minor drug interactions (161 brand and generic names)

Show all medications in the database that may interact with Myogesic (magnesium salicylate / phenyltoloxamine).

Check for interactions with Myogesic (magnesium salicylate / phenyltoloxamine)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Myogesic (magnesium salicylate / phenyltoloxamine)

Myogesic (magnesium salicylate / phenyltoloxamine) alcohol/food Interactions

There is 1 alcohol/food interaction with Myogesic (magnesium salicylate / phenyltoloxamine)

Myogesic (magnesium salicylate / phenyltoloxamine) disease Interactions

There are 13 disease interactions with Myogesic (magnesium salicylate / phenyltoloxamine) which include:

See also.

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.

Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.

Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

How to Prevent Deadly Drug Interactions

Exondys 51 Eteplirsen is a morpholino antisense oligomer for the treatment of Duchenne muscular dystrophy.

Yosprala Yosprala (aspirin and omeprazole) is a platelet aggregation inhibitor and proton pump inhibitor.

Cuvitru Cuvitru (immune globulin subcutaneous (human)) is indicated as replacement therapy in the treatment.

Erelzi Erelzi (etanercept-szzs) is a tumor necrosis factor (TNF) blocker biosimilar to Enbrel indicated.

FDA Consumer Updates

Myogesic Rating

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Zolodorm, Zolodorm

Zolpidem

Chemical Name

Foreign Names

Zolpidemum (Latin)

Zolpidem (German)

Zolpidem (French)

Zolpidem (Spanish)

Generic Names

Zolpidem (OS: BAN, DCF, DCIT)

SL 800750 (IS)

UNII-7K383OQI23 (IS)

Zolpidem Tartrate (OS: BANM, USAN, JAN)

HSDB 7045 (IS)

SL 800750-23N (IS)

UNII-WY6W63843K (IS)

Zolpidem hemitartrate (IS)

Zolpidem hydrogenotartras (IS)

Zolpidem (tartrat de) (PH: Ph. Eur. 8)

Zolpidem Tartrate (PH: BP 2016, JP XVI, USP 38)

Zolpidem tartrate (PH: Ph. Eur. 8)

Zolpidemi tartras (PH: Ph. Eur. 8)

Zolpidemtartrat (PH: Ph. Eur. 8)

Brand Names

Toxin Profiles

Zolpidem Identification Number: CASRN | 82626-48-0

Nastiness Attributes

Metabolic Interference or Disruption

Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.

Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

Exposure Produces Health Symptoms

Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

Has known Side Effects

This is often the result of long or short term medication use. The same medication can have a range of side effects ranging from none at all to totally debilitating symptoms within different individuals. Reasons for this include individual genetics, individual detoxification capacity, nutrition status, duration of use and total number of medications being taken.

It becomes very difficult to establish clear causes of symptoms when multiple medications are being taken at once.

See SIDE EFFECTS LINKOUT at end of this profile.

CATEGORIES: Medication or Drug | Food Toxin | Synthetic Toxin | Psychiatric Drug - Tranquilizers

SUBSTANCE LINEAGE: Organic Compounds | Heterocyclic Compounds | Azoles | Imidazoles | Phenylimidazoles

SYNONYMS: Adormix | Ambien | Ambien CR | Bikalm | Dormizol | Edluar | Hypnogen | Intermezzo | Ivadal | Ivedal | Myslee | N, N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamide | Nasen | Nimadorm | Nottem | Stilnoct | Stilnox | Stilnox CR | Zolpidem Ambien | Zolpidem tartrate | Zolpidemum | Zolpimist | Zolsana | Zoltis | 10-Nait, Adormix, Albapax, Alespan, Ambien, Ambulax-2, Amsic, Ansiozol, Atrimon, Bikalm, Cedrol, Conyx, Dalparan, Damixan, Dodorest, Dorlotil, Dormeben, Dormilan, Dormirex, Dormi-Ros, Dormizol, Dormosol, Dumitol, Edluar, Flazinil, Hipnatur, Hipnotab, Insodem, Insom, Intermezzo, Inzodem, Ivadal, Lioram, Litramol, Mondeal, Niotal, Nitrest, Nocpidem, Nocte, Noctum, Nokdrim, Nottem, Nuo Bin, Nytamel, Oniria, Sanval, Sedovalin, Somit, Somnil, Somnipax, Somnipron, Somno, Sovigen, Stildem, Stilnix, Stillnoct, Stilnoct, Stilnox, Stilpidem, Sublinox, Sucedal, Sumenan, Supedal, Talacen, Tardine, Uninorm, Vicknox, Viradex, Zaviana, Zimor, Ziohex, zodormdura, Zogno, Zolax, Zoldem, Zoldorm, Zoldox, Zolgen, Zolmia, Zolnod, Zolnox, Zolnuit, Zolodorm, Zolpeduar, Zolpibell, Zolpid, Zolpicin, Zolpidem, Zolpiden, Zolpidex, Zolpidohexal, Zolpi-Lich, Zolpi-Med, Zolpimist, Zolpinox, Zolpi-Q, Zolpitop, ZolpiWin, Zonata, Zopim, Zorimin

DESCRIPTION: Zolpidem (sold under the brand names Ambien, Ambien CR, Stilnox, and Sublinox) is a prescription medication used for the treatment of insomnia, as well as some brain disorders. It is a short-acting nonbenzodiazepine hypnotic of the imidazopyridine class that potentiates gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, by binding to GABAA receptors at the same location as benzodiazepines. It works quickly (usually within 15 minutes) and has a short half-life (two to three hours). Zolpidem has not adequately demonstrated effectiveness in maintaining sleep (unless delivered in a controlled-release form); however, it is effective in initiating sleep. Some users take zolpidem recreationally for these side effects. However, it may be less common than benzodiazepine abuse. Zolpidem can become addictive if taken for extended periods of time, due to dependence on its ability to put one to sleep or to the euphoria it can sometimes produce.

COMMENTS:

FORMULA: C19H21N3O

DATA SOURCES: DATA SOURCES: T3DB | PubChem | Drugbank | Peter Lehmann Psychiatric Drugs List

LAST UPDATE: 21/04/2015

Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

SYMPTOMS: Symptoms of overdose include impairment of consciousness ranging from somnolence to light coma.

POSSIBLE HEALTH CONSEQUENCES: They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive. | Zolpidem is converted to inactive metabolites in the liver. Route of Elimination: Zolpidem tartrate tablets are converted to inactive metabolites that are eliminated primarily by renal excretion. Half Life: 2.6 hours

ACTION OF TOXIN: Zolpidem modulates the alpha-subunit, known as the benzodiazepine receptor, within the GABA A receptor chloride channel macromolecular complex. Unlike the benzodiazepines, which non-selectively interact with all three alpha-receptor subtypes, Zolpidem preferentially binds to the alpha-1 receptor. | Zolpidem modulates the alpha-subunit, known as the benzodiazepine receptor, within the GABA A receptor chloride channel macromolecular complex. Unlike the benzodiazepines, which non-selectively interact with all three alpha-receptor subtypes, Zolpidem preferentially binds to the alpha-1 receptor.

TOXIN SITES OF ACTION IN CELL: "Membrane"

Additional Exposure Routes: For the short-term treatment of insomnia. SEE MEDICATION SIDE EFFECTS

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Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.

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Pharmacologic class: Calcium channel blocker

Therapeutic class: Antianginal, antiarrhythmic (class IV), antihypertensive

Pregnancy risk category C

Action

Inhibits calcium from entering myocardial and vascular smooth-muscle cells, thereby depressing myocardial and smooth-muscle contraction and decreasing impulse formation and conduction velocity. As a result, systolic and diastolic pressures decrease.

Availability

Capsules (extended-release, sustained-release ): 60 mg, 90 mg, 120 mg, 180 mg, 240 mg, 300 mg, 360 mg, 420 mg

Injection: 5 mg/ml in 10-ml vials, 100-mg Monovial

Tablets: 30 mg, 60 mg, 90 mg, 120 mg

⊘ Indications and dosages

➣ Angina pectoris and vasospastic (Prinzmetal's) angina; hypertension; supraventricular tachyarrhythmias; atrial flutter or fibrillation

Adults: 30 to 90 mg P. O. three to four times daily (tablets), or 60 to 120 mg P. O. b. i.d. (sustained-release), or 180 to 240 mg P. O. once daily (extended-release), adjusted after 14 days as needed, up to a total daily dosage of 360 mg. Or 0.25 mg/kg by I. V. bolus over 2 minutes; if response is inadequate after 15 minutes, may give 0.35 mg/kg over 2 minutes; may follow with continuous I. V. infusion at 10 mg/hour (at a range of 5 to 15 mg/hour) for up to 24 hours.

Dosage adjustment

• Severe hepatic or renal impairment • Elderly patients

Off-label uses

• Unstable angina, coronary artery bypass graft surgery • Tardive dyskinesia • Migraine • Hyperthyroidism • Raynaud's phenomenon

Contraindications

• Hypersensitivity to drug • Atrial flutter or fibrillation associated with shortened refractory period (Wolff-Parkinson-White syndrome, with I. V. use) • Recent myocardial infarction or pulmonary congestion • Cardiogenic shock, concurrent I. V. beta-blocker therapy, ventricular tachycardia, neonates (with I. V. use, because of benzyl alcohol in syringe formulation) • Sick sinus syndrome, second - or third-degree atrioventricular block (except in patients with ventricular pacemakers) • Hypotension (systolic pressure below 90 mm Hg)

Precautions

Use cautiously in: • severe hepatic or renal impairment, heart failure • history of serious ventricular arrhythmias • concurrent use of I. V. diltiazem and I. V. beta blockers • elderly patients • pregnant or breastfeeding patients • children (safety not established).

Administration

• When giving I. V. dilute in dextrose 5% in water or normal saline solution. • Give I. V. bolus dose over 2 minutes; a second bolus may be given after 15 minutes. • Administer continuous I. V. infusion at a rate of 5 to 15 mg/hour.

☞ When giving by continuous I. V. infusion, make sure emergency equipment is available and that patient has continuous ECG monitoring with frequent blood pressure monitoring. • Don't crush tablets or sustained-release capsules; they must be swallowed whole. • Withhold dose if systolic blood pressure falls below 90 mm Hg, diastolic pressure is below 60 mm Hg, or apical pulse is slower than 60 beats/minute.

Adverse reactions

CNS: headache, abnormal dreams, anxiety, confusion, dizziness, drowsiness, nervousness, psychiatric disturbances, asthenia, paresthesia, syncope, tremor

CV: peripheral edema, bradycardia, chest pain, hypotension, palpitations, tachycardia, arrhythmias, heart failure

EENT: blurred vision, tinnitus, epistaxis

GI: nausea, vomiting, diarrhea, constipation, dyspepsia, dry mouth

GU: urinary frequency, dysuria, nocturia, polyuria, gynecomastia, sexual dysfunction

Hematologic: anemia, leukopenia, thrombocytopenia

Musculoskeletal: joint stiffness, muscle cramps

Respiratory: cough, dyspnea

Skin: rash, dermatitis, flushing, diaphoresis, photosensitivity, pruritus, urticaria, erythema multiforme

Other: unpleasant taste, gingival hyperplasia, weight gain, decreased appetite, Stevens-Johnson syndrome

Interactions

Drug-drug. Beta-adrenergic blockers, digoxin, disopyramide, phenytoin: bradycardia, conduction defects, heart failure

Carbamazepine, cyclosporine, quinidine: decreased diltiazem metabolism, increased risk of toxicity

Cimetidine, ranitidine: increased blood level and effects of diltiazem

Fentanyl, nitrates, other antihypertensives, quinidine: additive hypotension

HMG-CoA reductase inhibitors, imipramine, sirolimus, tacrolimus: increased blood levels of these drugs

Lithium: decreased lithium blood level, reduced antimanic control

Nonsteroidal anti-inflammatory drugs: decreased antihypertensive effect of diltiazem

Theophylline: increased theophylline effects

Drug-diagnostic tests. Hepatic enzymes: increased levels

Drug-food. Grapefruit juice: increased blood level and effects of diltiazem

Drug-behaviors. Acute alcohol ingestion: additive hypotension

Patient monitoring

• Check blood pressure and ECG before starting therapy, and monitor closely during dosage adjustment period. Withhold dose if systolic pressure is below 90 mm Hg.

☞ Monitor for signs and symptoms of heart failure and worsening arrhythmias. • Supervise patient during ambulation.

Patient teaching

• Instruct patient to swallow extended-release capsules whole and not to crush or chew them. • Advise patient to change position slowly to minimize light-headedness and dizziness. • Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and behaviors mentioned above.

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Selan Exploration Technology Limited (SELAN) is a private sector listed company, incorporated in 1985, engaged in oil exploration and production since 1992.

The Promoters and Management have extensive experience and domain knowledge in the field of Petroleum Exploration, Development and Production as well as in the field of Geophysical Data Acquisition, Processing and Interpretation.

Following the move by the Government of India in 1992 in opening up the oil sector for private initiative in exploration and production of Hydrocarbons, SELAN was amongst the first private sector companies to have obtained rights to develop three discovered oilfields situated in the state of Gujarat namely Bakrol, Indrora and Lohar, all with proven oil and gas reserves. SELAN was subsequently awarded two more fields in Gujarat namely Ognaj Oilfield and Karjisan Gas field.

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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Vasotop

Vasotop is a drug that is used in the management of congestive heart failure in dogs. Vasotop is manufactured by Intervet Schering-Plough and is available in three sizes of tablets, 1.25mg, 2.5mg and 5mg. Ramipril is the active ingredient in Vasotop which belongs to a class of drugs called Angiotensin Converting Enzyme Inhibitors. Vasotop tablets are given once daily with food.

Vasotop is used to treat cases of decompensated congestive heart failure in dogs. The clinical signs associated with heart failure as well as the prognosis improve when giving Vasotop as it helps to support the cardiovascular system. Vasotop is often used with other drugs also designed to support heart function, specifically diuretics such as frusemide, used to stop the lungs filling with fluid and a drug called digoxin which is used to treat abnormal heart rhythms.

· The dose of Vasotop is based on weight so weigh your pet regularly

· You should only give Vasotop to your pet if directed by a vet to do so

· Vasotop is usually given once a day

· If you see any side effects after giving Vasotop then call your vet

· Vasotop is available in three sizes to improve accuracy of dosing

· Contact your vet immediately if you suspect an overdose of Vasotop

· Vasotop will often be given along with other drugs

· Store Vasotop in a dry place, under 30 o C

· Keep Vasotop out of reach of children

· Vomiting, diarrhoea and anorexia are the main side effects that are seen

· Call your vet if you suspect any adverse reactions to Vasotop

· Low blood pressure may occur at higher doses of Vasotop

· Higher doses of Vasotop may cause lethargy

· You must be careful giving Vasotop with other drugs that can lower blood pressure

· Vasotop should be used cautiously in animals with existing kidney disease

· Kidney parameters should be monitored while on treatment with Vasotop

· No information is available about the use of Vasotop in pregnant bitches

· Vasotop comes in 1.25mg, 2.5mg and 5mg tablets

· Vasotop tablets are scored to make dividing them easier

· The dose of Vasotop will be calculated according to the weight of your pet

· Your vet will advise you on the correct dose of Vasotop

· Vasotop is given once daily

· Vasotop can be given with food

· The dose can be increased with severe disease but this will be decided by your vet

· Do not change the dose of Vasotop without consulting your vet.

· Vasotop can be given with other medications

Further Information about Vasotop

Vasotop is a drug used in the management of congestive heart failure in dogs and contains the active ingredient Ramipril. Vasotop is available in 1.25mg, 2.5mg and 5mg tablets and the exact dose will depend on the weight of your pet. Vasotop is a POM-V class drug which means it needs to be prescribed by the vet who is looking after your pet.

Ramipril is part of a class of drugs called Angiotensin Converting Enzyme Inhibitors. Vasotop will reduce the conversion of Angiotensin I to Angiotensin II. Angiotensin II causes constriction of blood vessels which increases the resistance that the heart has to pump against. Vasotop will therefore reduce this resistance, helping the heart to pump blood more effectively. The ramipril in Vasotop is converted to ramiprilat, the active form, in the liver.

Vasotop can be given once daily with food. Occasionally side effects such as vomiting, diarrhoea and anorexia can be seen. At higher doses of Vasotop and sometimes after a dose change animals can seem lethargic and have an unsteady gait. Call your vet if you see any potential side effects from Vasotop.

Further information about dosing and administration of Vasotop

The dose of Vasotop in dogs is 1.25mg ramipril per kilogram of your pet’s bodyweight. It is therefore important that you weigh your pet regularly so that the dose is always accurate. The dose is given once daily with, 1.25mg, 2.5mg or 5mg tablets or a combination. Vasotop 1.25mg tablets are beige and scored for easy dividing. Vasotop 2.5mg tablet are yellow in colour and scored and Vasotop 5mg are pink in colour and again, scored so they can be divided.

This dose of Vasotop can be increased after two weeks in cases of severe disease but this should only be done under the supervision and guidance of your vet. Vasotop tablets can be given with food or directly into the mouth. Vasotop is often given in conjunction with other drugs to better control the heart failure.

The dosage chart below shows a suggested dosing schedule for Vasotop.

Frequently asked questions

Q. What does Vasotop do?

A. Vasotop helps improve the quality of life of dogs with heart failure but helping the heart to pump more effectively

Q. How much Vasotop should I give my dog?

A. The exact dose is based on your pet’s weight and will be decided by your vet but the above table gives a suggested dose rate.

Q. Can I split the Vasotop tablet?

A. Yes, Vasotop tablets are designed to be split in half for more accurate dosing.

Q. How long will my dog need to be taking Vasotop?

A. Once treatment is started it is usually required for the rest of the dog’s life as heart failure is managed rather than cured.

Q. How is Vasotop administered?

A. Vasotop must be given by mouth but can be given once daily in food.

Q. Does Vasotop have any side effects?

A. Vasotop can occasionally have side effects such as vomiting, diarrhoea, anorexia and lethargy. If you see any of these problems then call your vet for advice.

Q. What should I do if I give my pet an extra dose of Vasotop by mistake?

A. Call your vet immediately for advice and monitor your pet for any problems.

Q. Does it matter if I miss a dose of Vasotop by mistake?

A. It is always best to adhere closely to the dose regime advised by your vet but if you miss a dose then just give the next dose as normal, don’t give double the dose next time.

Q. Is it possible that the Vasotop will stop working?

A. The Vasotop may stop having such a beneficial effect on your pet if the heart disease is getting progressively worse. If you see signs of deterioration in your pet then contact your vet as soon as possible.

Q. How often should my dog be rechecked at the vets?

A. This will need to be done regularly to start with then can be less often if your pet is stable. Rechecks are usually no less then every 6 months but the exact schedule will be determined by your vet.



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IBUPROFEN 400 MG TABLETS

Transcript

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



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Pravastatin Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Pravastatine

pravastatin

GENERIC NAME(S): PRAVASTATIN SODIUM

Uses

Pravastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL. triglycerides ) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of drugs known as "statins ." It works by reducing the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks .

In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising. losing weight if overweight. and stopping smoking. Consult your doctor for more details.

How to use pravastatin

Take this medication by mouth with or without food as directed by your doctor, usually once daily. For best results, take this medication in the evening.

The dosage is based on your medical condition, response to treatment, age, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

If you also take certain other drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol ), take pravastatin at least 1 hour before or at least 4 hours after taking these medications. These products can react with pravastatin, preventing its full absorption.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high cholesterol or triglycerides do not feel sick.

It is very important to continue to follow your doctor's advice about diet and exercise. It may take up to 4 weeks before you get the full benefit of this drug.

Side Effects

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very small number of people taking pravastatin may have mild memory problems or confusion. If these rare effects occur, talk to your doctor.

Rarely, statins may cause or worsen diabetes. Talk to your doctor about the benefits and risks.

This drug may rarely cause muscle problems (which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy). Tell your doctor right away if you develop any of these symptoms during treatment and if these symptoms persist after your doctor stops this drug: muscle pain /tenderness/weakness (especially with fever or unusual tiredness), signs of kidney problems (such as change in the amount of urine).

This medication may rarely cause liver problems. If you notice any of the following rare but serious side effects, tell your doctor right away: yellowing eyes /skin. dark urine, severe stomach /abdominal pain. persistent nausea /vomiting .

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking pravastatin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease. alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Limit alcoholic beverages. Daily use of alcohol may increase your risk for liver problems, especially when combined with pravastatin. Ask your doctor or pharmacist for more information.

Older adults may be more sensitive to the side effects of this drug, especially muscle problems.

This medication must not be used during pregnancy. Pravastatin may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control (such as condoms. birth control pills ) while taking this medication. If you become pregnant or think you may be pregnant, tell your doctor right away.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

See also How To Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: colchicine, gemfibrozil.

Do not take any red yeast rice products while you are taking pravastatin because some red yeast rice products may also contain a statin called lovastatin. Taking pravastatin and red yeast rice products together can increase your risk of serious muscle and liver problems.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as blood cholesterol/triglyceride levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59 and 86 degrees F (15 to 30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised April 2016. Copyright(c) 2016 First Databank, Inc.

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Ceftin is used for treating bacterial infections (sinus, skin, lung, urinary tract, ear, and throat). It may also be used to treat Lyme disease and gonorrhea. Ceftin is a cephalosporin antibiotic. It works by interfering with the formation of the bacteria's cell wall so that the wall ruptures, resulting in the death of the bacteria.

Use Ceftin as directed by your doctor.

Take Ceftin by mouth with or without food.

Swallow Ceftin whole. Do not break, crush, or chew before swallowing.

Ceftin works best if it is taken at the same time each day.

To clear up your infection completely, take Ceftin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Ceftin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose, and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ceftin.

Store Ceftin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ceftin out of the reach of children and away from pets.

Active Ingredient: Cefuroxime axetil.

Do NOT use Ceftin if:

you are allergic to any ingredient in Ceftin or to any other cephalosporin antibiotic (eg, cephalexin, cefprozil).

Contact your doctor or health care provider right away if any of these apply to you.

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach or intestinal infection, or a blood clotting problem

if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to a penicillin antibiotic (eg, amoxicillin) or other beta-lactam antibiotic (eg, imipenem).

Some medicines may interact with Ceftin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aminoglycosides (eg, gentamicin), cyclosporine, diuretics (eg, furosemide, hydrochlorothiazide), or other medicines affecting the kidney because side effects, such as kidney toxicity, may occur

Hormonal contraceptives (eg, birth control pills) because their effectiveness may be decreased by Ceftin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ceftin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur during treatment or within several months after treatment with Ceftin. Do not treat diarrhea without first checking with your doctor.

The tablet and oral suspension forms of Ceftin are not equivalent. Do not substitute one for the other.

Ceftin only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use Ceftin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Ceftin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Diabetes patients - Ceftin may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Ceftin. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Lab tests, including liver function, kidney function, and complete blood cell count, may be performed while you use Ceftin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Ceftin should not be used in children younger 3 months; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ceftin while you are pregnant. Ceftin is found in breast milk. Do not breastfeed while taking Ceftin.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea/loose stools; nausea; vomiting. Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; change in the amount of urine; dark urine; easy bruising or bleeding; fatigue; fever; seizures; severe diarrhea; stomach cramps/pain; vaginal irritation or discharge; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Nimotop (Nimodipine) is in a group of drugs called calcium channel blockers. Nimodipine relaxes (widens) blood vessels and improves blood flow.

Nimodipine is used to prevent brain damage caused by reduced blood flow to the brain resulting from aneurysm (AN-yor-iz-m), a dilated or ruptured blood vessel in the brain.

Nimodipine may also be used for purposes other than those listed here.

Take nimodipine exactly as it was prescribed for you. Do not take it in larger doses or for longer than recommended by your doctor.

Nimodipine gel capsules are to be taken by mouth only. The medicine in the capsule should never be placed into a needle and syringe and injected into a vein. If the person taking nimodipine cannot swallow the capsule, use a needle to make a hole in each end of the capsule, and squeeze the medicine out into an oral syringe. The syringe can then be used to give the medicine through a nasogastric (through the nose and into the stomach) tube. If you are able to swallow capsules, take nimodipine on an empty stomach, one hour before or two hours after meals. Take each dose with a full glass of water.

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To be sure this medication is helping your condition, your blood pressure will need to be tested on a regular basis. Your liver function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

Take the medicine as prescribed by your doctor.

Store nimodipine at room temperature away from moisture and heat.

Active ingredient: Nimodipine

Nimotop (nimodipine) belongs to the class of pharmacological agents known as calcium channel blockers.

Before taking nimodipine, tell your doctor if you have liver disease, low blood pressure, high blood pressure (hypertension) for which you take medicine, or a history of heart problems such as a slow heart rate, congestive heart failure, or heart attack.

Nimodipine gel capsules are to be taken by mouth only. The medicine in the capsule should never be placed into a needle and syringe and injected into a vein. If the person taking nimodipine cannot swallow the capsule, use a needle to make a hole in each end of the capsule, and squeeze the medicine out into an oral syringe. The syringe can then be used to give the medicine through a nasogastric (through the nose and into the stomach) tube.

If you are able to swallow capsules, take nimodipine on an empty stomach, one hour before or two hours after meals. Avoid drinking alcohol while you are taking nimodipine. Alcohol and nimodipine may cause low blood pressure, drowsiness, or dizziness. Do not stop taking nimodipine without first talking to your doctor, even if you begin to feel better. If you stop taking the medication, your condition could become worse.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known if nimodipine passes into breast milk or if it could harm a nursing infant. Do not take nimodipine without telling your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to have side effects from nimodipine. Your doctor may prescribe a lower dose of this medication.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using nimodipine and call your doctor at once if you have any of these serious side effects:

unusually fast or slow heartbeats;

fainting or severe dizziness;

easy bruising or bleeding, unusual weakness;

swelling in your legs or ankles.

Other, less serious side effects may be more likely. Continue taking Nimovac-v and talk to your doctor if you have any of these less serious side effects:

flushing (redness, warmth, or tingling feeling);

nausea, constipation; or

Side effects other than those listed here may also occur.

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Satil

This is recently opened Indian restaurant in my neighborhood. There're three one-table seats and 4 two-table seats in the small restaurant, so the lunch time is pretty much occupied between the noon and after 1pm for office workers in this area and have to wait or other ramen shops around this neighbor.

The lunch set is a curry which is from roughly 20 kinds and a soft drink ( I recommend a mango lassi), choice of rice or nan (both free refill). The curry tastes good and freshly made nan they serve is pretty big, over 40cm, and tasty so the range of 800-900 is pretty reasonable.

Just one thing I was disappointed then was some customers smoke there inside of the small restaurant at the busy lunch time. I know these restaurants cannot say no to smoker for not to losing customer but I wish customer can consider about the situation.

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Bisacardiol ar tankt nar det galler aldre bara anvanda.

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Bisacardiol (Zebeta) Negativa effekter

Bisacardiol erbjuder de negativa effekterna. Den mest typiska tenderar att vara:

forbattrad svett friktionsmaterial

trotthet friktionsmaterial

huvudvark friktionsmaterial

torkat munnen omrade friktionsmaterial

somnloshet friktionsmaterial

diarre friktionsmaterial

illamaende eller krakningar friktionsmaterial

kastar upp friktionsmaterial

hosta friktionsmaterial

rinit friktionsmaterial

faryngit friktionsmaterial

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Mycket mindre vanliga och allvarliga negativa effekter hela anvander Bisacardiol: allergisk reaktion reaktioner (urtikaria, andas in och andas problem, allergi, samt utbrott).

Negativa effekter indikationer ar beroende av medicin du kanske anvander men dessutom lita pa ditt valbefinnande villkor och en annan aspekter.

Bisacardiol (Zebeta) Kontraindikationer

Vanligtvis inte far Bisacardiol om du ar kanslig for att Bisacardiol element eller ens jamforbara lakemedel.

Var forsiktig tillsammans med Bisacardiol om du vantar annars du tanker ha ett barn, annars ar du verkligen en medicinsk mamma.

Vanligtvis inte utnyttjar Bisacardiol till betablockerare fastighetsmaklare.

Vanligtvis inte utnyttjar Bisacardiol lider tillsammans med kardiogen overraskning, oppen hjarta misslyckas, 2: a eller ens 3: e nivan AUDIO-VIDEO forhindrar, liksom mark nasa bradykardi.

Var forsiktig tillsammans med Bisacardiol om du anvander hjartdepressiva, hammare i samband med AUDIO-VIDEO borgen.

Var forsiktig tillsammans med Bisacardiol om du drabbas av suprarrenal liksom lever funktionshinder.

Vanligtvis inte utnyttjar kalium kosttillskott eller ens natrium alternativ.

Om du vill astadkomma basta resultat med nagra negativa effekter ar det lampligt att undvika alkoholhaltiga drycker.

Vanligtvis inte sluta anvanda Bisacardiol helt plotsligt.

Bisacardiol (Zebeta) Vanliga fragor

Queen: Mycket basta fokus pa i samband med Bisacardiol?

Bisacardiol anvands for att behandla hogt blodtryck (hogt blodomloppet tryck) A

Queen: Vad exakt ar Bisacardiol?

Bisacardiol (bisoprololfumarat) ar verkligen en konstgjord, beta 1-selektiva (kardioselektiv) adrenoceptor hindrar fastigheter agent. A

Queen: Sa hur exakt gor Bisacardiol tillganglig?

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Queen: Mycket basta normal dos i samband med Bisacardiol?

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My knowledge is constantly improving. I still make mistakes and sometimes give bad recommendations, but I'm getting better. I'm learning from you, the people who use my service. If you want to help me, fill in your profile!

I'm Emmy!

I provide recommendations and help you discover new music, movies, TV shows, books, authors and games, based on what you like. Some call me a recommendation engine, but I prefer to simply be called TasteKid. Explore your taste!

Better discovery experience

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Zolpidem

Chemical Name

Foreign Names

Zolpidemum (Latin)

Zolpidem (German)

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Generic Names

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Bonemax

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BoneMax

BoneMax

Supports Bone Metabolism

Supports Bone Strength

Provides Micronutrients for Utilization in Bone Production and Structure

Ossopan is a well-researched, standardized extract from one of the world’s safest premium sources of bone—free-range New Zealand cattle. Ossopan contains microcrystalline hydroxyapatite concentrate (MCHC), a complex crystalline compound containing calcium, phosphorus, bioactive growth factors, type I collagen, amino acids, glycosaminoglycans, and a broad range of essential trace elements that naturally comprise healthy bone.* Bone Max MD delivers 500 mg of MCHC per capsule along with additional calcium and magnesium in the form of highly absorbable Albion® minerals. Vitamin D, in the form of cholecalciferol, supports intestinal calcium absorption and homeostasis in the body and completes the comprehensiveness of this bone-support formula.*

All Center for Natural HealthCare Formulas Meet or Exceed cGMP Quality Standards

Directions

Take two capsules with meals, twice daily, or as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged. The labeling on this product does not comply with California’s Proposition 65. Therefore, this product may not be sold in California.

Does Not Contain

Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Supplement Facts

Serving Size: 2 Capsules Servings Per Container: 60

Amount Per Serving% Daily Value

Vitamin D3 (cholecalciferol)

Calcium (as MCHC † and DimaCal ® di-calcium malate)

Phosphorus (as MCHC † )

Magnesium (as Albion ® di-magnesium malate)

Microcrystalline Hydroxyapatite (as MCHC † )

** Daily Value not established. † Microcrystalline Hydroxyapatite Concentrate

All XYMOGEN® Formulas Meet or Exceed cGMP Quality Standards.

Discussion

More than 20 years of scientific research have given the name Ossopan worldwide recognition as a source of microcrystalline hydroxyapatite concentrate (MCHC). Numerous published studies support the safety, tolerability, and bone health-related effectiveness of MCHC supplementation.[1,2] Studies suggest that the bioavailability of calcium from MCHC supplements may be as good as or better than the bioavailability of calcium from calcium gluconate supplements.[3,4] Center for Natural HealthCare utilizes standardized, safe, bovine-sourced MCHC from New Zealand, a country with stringent standards. Its production features a proprietary technique that preserves the bioactive contents of bone. This process creates a naturally balanced formula because whole bone extract provides all of the nutrients found in healthy bone.*

Unlike other calcium supplements on the market, Ossopan consists of collagenous and non-collagenous proteins and peptides. These compounds include insulin-like growth factors I and II (IGF-I, IGF-II), transforming growth factor beta (TGF-beta), and osteocalcin, factors that stimulate alkaline phosphatase activity and support metabolism in human bone cells.[5] Removal of the protein fraction appears to reduce the positive effects of the formula, highlighting the importance of its presence.*[6]

A study suggested that the occurrence of positive and statistically significant changes in forearm bone integrity were the result of daily supplementation with 3000 mg of microcrystalline hydroxyapatite.[7] Earlier studies compared Ossopan to other forms of calcium with regard to the support of normal bone turnover and bone mineral integrity. In one 20-month, double-blind study, women were given 1400 mg of elemental calcium (equivalent to approximately 5000 mg MCHC) as either calcium carbonate or Ossopan. At the end of the study, the presence of bone integrity was statistically significant in the Ossopan group.*[8]

Clinical trials suggested that Ossopan supplementation was well-tolerated and yielded a positive outcome for dental status, bone integrity, and healthy bone metabolism.[9,10] A randomized, controlled study indicated that the addition of Ossopan to exogenously administered hormones provided statistically significant support (4.7%, P<0.1) to vertebral bone mass.[10] Another study of 60 subjects suggested that bone mass was maintained while on Ossopan.*[11]

Ossopan is high-quality MCHC from New Zealand. The World Organization for Animal Health (the OIE) has classified New Zealand as a “negligible BSE risk country,” the most favorable official classification a country can be given.[12] Ossopan is manufactured under proprietary processes that meet FDA, USDA, and EU regulatory requirements. Gentle processing is used to retain the delicate protein matrix and organic factors. X-ray-diffraction analysis confirms the microcrystalline structure. The MCHC is assayed for hydroxyproline content. The collagen content is greater than 22% with the majority being type l, the predominant collagen occurring in bone. Frequent heavy metal assays assure purity.

Bone Max MD delivers 500 mg of Ossopan per capsule along with vitamin D, magnesium, and additional calcium. Vitamin D is provided as cholecalciferol, which stimulates intestinal calcium absorption and helps support calcium and phosphorus homeostasis in the body. Calcium is provided as MCHC and DimaCal® dicalcium malate, and magnesium is provided as Albion dimagnesium malate and TRAACS® magnesium bisglycinate chelate. The buffering malate forms of calcium and magnesium do not react with stomach acid and are less likely than carbonates to cause discomfort and acid rebound.*[13]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

BoneMax

BoneMax

Supports Bone Metabolism

Supports Bone Strength

Provides Micronutrients for Utilization in Bone Production and Structure

Ossopan is a well-researched, standardized extract from one of the world’s safest premium sources of bone—free-range New Zealand cattle. Ossopan contains microcrystalline hydroxyapatite concentrate (MCHC), a complex crystalline compound containing calcium, phosphorus, bioactive growth factors, type I collagen, amino acids, glycosaminoglycans, and a broad range of essential trace elements that naturally comprise healthy bone.* Bone Max MD delivers 500 mg of MCHC per capsule along with additional calcium and magnesium in the form of highly absorbable Albion® minerals. Vitamin D, in the form of cholecalciferol, supports intestinal calcium absorption and homeostasis in the body and completes the comprehensiveness of this bone-support formula.*

All Center for Natural HealthCare Formulas Meet or Exceed cGMP Quality Standards

Directions

Take two capsules with meals, twice daily, or as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged. The labeling on this product does not comply with California’s Proposition 65. Therefore, this product may not be sold in California.

Does Not Contain

Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Supplement Facts

Serving Size: 2 Capsules Servings Per Container: 60

Amount Per Serving% Daily Value

Vitamin D3 (cholecalciferol)

Calcium (as MCHC † and DimaCal ® di-calcium malate)

Phosphorus (as MCHC † )

Magnesium (as Albion ® di-magnesium malate)

Microcrystalline Hydroxyapatite (as MCHC † )

** Daily Value not established. † Microcrystalline Hydroxyapatite Concentrate

All XYMOGEN® Formulas Meet or Exceed cGMP Quality Standards.

Discussion

More than 20 years of scientific research have given the name Ossopan worldwide recognition as a source of microcrystalline hydroxyapatite concentrate (MCHC). Numerous published studies support the safety, tolerability, and bone health-related effectiveness of MCHC supplementation.[1,2] Studies suggest that the bioavailability of calcium from MCHC supplements may be as good as or better than the bioavailability of calcium from calcium gluconate supplements.[3,4] Center for Natural HealthCare utilizes standardized, safe, bovine-sourced MCHC from New Zealand, a country with stringent standards. Its production features a proprietary technique that preserves the bioactive contents of bone. This process creates a naturally balanced formula because whole bone extract provides all of the nutrients found in healthy bone.*

Unlike other calcium supplements on the market, Ossopan consists of collagenous and non-collagenous proteins and peptides. These compounds include insulin-like growth factors I and II (IGF-I, IGF-II), transforming growth factor beta (TGF-beta), and osteocalcin, factors that stimulate alkaline phosphatase activity and support metabolism in human bone cells.[5] Removal of the protein fraction appears to reduce the positive effects of the formula, highlighting the importance of its presence.*[6]

A study suggested that the occurrence of positive and statistically significant changes in forearm bone integrity were the result of daily supplementation with 3000 mg of microcrystalline hydroxyapatite.[7] Earlier studies compared Ossopan to other forms of calcium with regard to the support of normal bone turnover and bone mineral integrity. In one 20-month, double-blind study, women were given 1400 mg of elemental calcium (equivalent to approximately 5000 mg MCHC) as either calcium carbonate or Ossopan. At the end of the study, the presence of bone integrity was statistically significant in the Ossopan group.*[8]

Clinical trials suggested that Ossopan supplementation was well-tolerated and yielded a positive outcome for dental status, bone integrity, and healthy bone metabolism.[9,10] A randomized, controlled study indicated that the addition of Ossopan to exogenously administered hormones provided statistically significant support (4.7%, P<0.1) to vertebral bone mass.[10] Another study of 60 subjects suggested that bone mass was maintained while on Ossopan.*[11]

Ossopan is high-quality MCHC from New Zealand. The World Organization for Animal Health (the OIE) has classified New Zealand as a “negligible BSE risk country,” the most favorable official classification a country can be given.[12] Ossopan is manufactured under proprietary processes that meet FDA, USDA, and EU regulatory requirements. Gentle processing is used to retain the delicate protein matrix and organic factors. X-ray-diffraction analysis confirms the microcrystalline structure. The MCHC is assayed for hydroxyproline content. The collagen content is greater than 22% with the majority being type l, the predominant collagen occurring in bone. Frequent heavy metal assays assure purity.

Bone Max MD delivers 500 mg of Ossopan per capsule along with vitamin D, magnesium, and additional calcium. Vitamin D is provided as cholecalciferol, which stimulates intestinal calcium absorption and helps support calcium and phosphorus homeostasis in the body. Calcium is provided as MCHC and DimaCal® dicalcium malate, and magnesium is provided as Albion dimagnesium malate and TRAACS® magnesium bisglycinate chelate. The buffering malate forms of calcium and magnesium do not react with stomach acid and are less likely than carbonates to cause discomfort and acid rebound.*[13]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.



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Urobiotic (Oxytetracycline, Sulfamethizole And Phenazopyridine) Drug Information Indications, Dosage

INDICATIONS

Based on a review of this drug by the National Academy of Sciences-National Research Council and/or other information, FDA has classified the indications as follows:

"Lacking substantial evidence of effectiveness as a fixed combination":

Urobiotic (oxytetracycline, sulfamethizole and phenazopyridine) -250 is indicated in the therapy of a number of genitourinary infections caused by susceptible organisms. These infections include the following: pyelonephritis, pyelitis, ureteritis, cystitis, prostatitis, and urethritis.

Since both Terramycin and sulfamethizole provide effective levels in blood, tissue, and urine, Urobiotic (oxytetracycline, sulfamethizole and phenazopyridine) -250 provides a multiple antimicrobial approach at the site of infection. Both antibacterial components are active against the most common urinary pathogens, including Escherichia coli, Pseudomonas aeruginosa, Aerobacter aerogenes, Streptococcus faecalis, Streptococcus hemolyticus . and Micrococcus pyogenes . Urobiotic (oxytetracycline, sulfamethizole and phenazopyridine) -250 is particularly useful in the treatment of infections caused by bacteria more sensitive to the combination than to either component alone. The combination is also of value in those cases with mixed infections, and in those instances where the causative organism is unknown pending laboratory isolation.

Final classification of the less than effective indications requires further investigation. Clinical studies to substantiate the efficacy of Urobiotic (oxytetracycline, sulfamethizole and phenazopyridine) -250 are ongoing. Completion of these ongoing studies will provide data for final classification of these indications.

DOSAGE AND ADMINISTRATION

Urobiotic (oxytetracycline, sulfamethizole and phenazopyridine) -250 is recommended in adults only. A dose of 1 capsule four times daily is suggested. In refractory cases 2 capsules four times a day may be used.

Therapy should be continued for a minimum of seven days or until bacteriologic cure in acute urinary tract infections.

Administration of adequate amounts of fluid along with capsule forms of drugs in the tetracycline class is recommended to wash down the drugs and reduce the risk of esophageal irritation and ulceration. (See ADVERSE REACTIONS .)

To aid absorption of the drug, it should be given at least one hour before or two hours after eating. Aluminum hydroxide gel given with antibiotics has been shown to decrease their absorption and is contraindicated.

HOW SUPPLIED

Urobiotic (oxytetracycline, sulfamethizole and phenazopyridine) -250 capsules: bottles of 50 ( NDC 0049-0920-50), and unit dose packages of 100 (10 X 10's) ( NDC 0049-0920-41).

Revised Dec. 1986.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 8/24/2009



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Diflucan Uses, Dosage - Side Effects, Flucan

Diflucan

Diflucan (fluconazole) is an antifungal medicine.

Diflucan is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, bladder, genital area, and the blood.

Diflucan is also used to prevent fungal infection in people who have a weak immune system caused by cancer treatment, bone marrow transplant. or diseases such as AIDS .

Important information

Certain other drugs can cause unwanted or dangerous effects when used with Diflucan, especially cisapride, erythromycin, pimozide, and quinidine. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.

Before taking Diflucan, tell your doctor if you have liver disease, kidney disease, a heart rhythm disorder, or a history of Long QT syndrome.

Take Diflucan for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antifungal medication. Diflucan will not treat a viral infection such as the common cold or flu.

Before taking this medicine

You should not use Diflucan if you are allergic to fluconazole, or if you also take cisapride, erythromycin, pimozide, or quinidine.

To make sure Diflucan is safe for you, tell your doctor if you have:

heart disease or heart rhythm disorder;

a personal or family history of Long QT syndrome;

kidney disease; or

if you are allergic to other antifungal medicine (such as ketoconazole, itraconazole, miconazole, posaconazole, voriconazole, and others).

Diflucan oral suspension (liquid) contains sucrose. Talk to your doctor before using this form of fluconazole if you have a problem digesting sugars or milk.

A single dose of Diflucan taken to treat a vaginal yeast infection is not expected to harm an unborn baby.

Do not take more than 1 dose of Diflucan if you are pregnant. Long-term use of high doses fluconazole can harm an unborn baby or cause birth defects. Tell your doctor if you become pregnant during treatment.

Diflucan can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy while taking Diflucan for more than 1 dose.

Fluconazole can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Diflucan?

Take Diflucan exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Your dose will depend on the infection you are treating. Vaginal infections are often treated with only one pill. For other infections, your first dose may be a double dose. Carefully follow your doctor's instructions.

You may take Diflucan with or without food.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Diflucan will not treat a viral infection such as the flu or a common cold.

Call your doctor if your symptoms do not improve, or if they get worse while using Diflucan.

Store the tablets at room temperature away from moisture and heat.

You may store liquid Diflucan in a refrigerator, but do not allow it to freeze. Throw away any leftover liquid medicine that is more than 2 weeks old.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include confusion or unusual thoughts or behavior.

What should I avoid while taking Diflucan?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Diflucan side effects

Get emergency medical help if you have any signs of an allergic reaction to Diflucan . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

fever, chills, body aches, flu symptoms;

easy bruising or bleeding, unusual weakness;

liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

skin rash or skin lesions; or

severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Diflucan side effects may include:

stomach pain, diarrhea, upset stomach;

changes in your sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Diflucan?

Certain other drugs can cause unwanted or dangerous effects when used with Diflucan. Your doctor may need to change your treatment plan if you use any of the following drugs:



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Labileno (Lamictal) Explicacion

Labileno es realmente una medicina senalo en relacion con el tratamiento complementario con respecto a la infancia utilizando los tipos siguientes de incautacion por ejemplo convulsiones incompletas, principales convulsiones tonico-clonicas generales, convulsiones generales asociadas al sindrome de Lennox sintomas - Gastaut; monoterapia con respecto a madurar a lo largo de los enfermos con convulsiones incompletas que estan recibiendo, ademas, su propia terapia junto con la carbamazepina, fenitoina, fenobarbital, primidona, asi como valproato; bipolar terapia grupos de apoyo con respecto a los adultos. Labileno le ayuda a manejar los ataques de sentimientos (depresion, odio, hipomania, asi como episodios combinados).

Labileno sigue siendo un impacto asociado con las estaciones de sal. Por lo tanto, Labileno mantiene lejos estaciones de sal respaldo paredes ansiosos, asi como hereupon regulan presinaptica todo eso lanzamiento asociado con proteinas excitatorias.

Labileno tambien puede ser referido como lamotrigina, Lametec.

titulo general asociada con Labileno es en realidad lamotrigina.

Marca asociada con Labileno Labileno es en realidad.

Labileno (Lamictal) Dosis

Labileno viene en:

25 mg Baja Dosis material de friccion

50 mg de material Regular friccion Dosis

100mg Mejora de material de friccion Dosis

Llevelo por via oral.

Labileno puede utilizarse a traves de los adultos y los ninos.

Si usted desea lograr mejores resultados por lo general no dejar de usar Labileno de repente.

Labileno (Lamictal) Careciendo asocia con dosis

Por lo general, no reciben doble dosis. En caso de que salte la dosis que necesita para llevar una vez se tiene en cuenta en lo que respecta a su deficiente. Cuando es hora de la dosis que necesita para llevar a cabo su propia rutina de dosificacion normal.

Labileno (Lamictal)

En el caso de que una sobredosis de Labileno y que tambien se evita gran usted necesita comprobar hacia fuera su medico o incluso el medico de inmediato. Asociado con la sobredosis de Labileno: ataxia, nistagmus, la mejora de las convulsiones, disminucion de grado de conciencia, coma, fianza intraventricular mantener a raya.

Labileno (Lamictal) Espacio de almacenamiento

Tienda en temperaturas de espacio entre 10 y 30 niveles de D (59, asi como ochenta y seis niveles F) de humedad, asi como la temperatura. Fortalecer cualquier tipo de medicamento sin tocar a partir del dia de vencimiento. Mantener colocado de forma segura fuera del camino de los ninos.

Labileno (Lamictal) Efectos negativos

Labileno ofrece los efectos negativos. El mas tipico tienden a ser:

material de friccion migrana Material

sintomas de influenza friccion

nauseas o vomitos material de friccion

arcadas material de friccion

material de friccion diarrea

material de friccion charla problema

material de friccion vision borrosa

Mucho menos tipica y efectos negativos graves en todo el uso de Labileno:

respuestas reaccion alergica (urticaria, inhalando y exhalando, cuestiones de alergia, asi como la erupcion) material de friccion

poros y la piel severas empuja friccion materiales Material

respuestas de hipersensibilidad friccion

multiorganica severa material de friccion en su defecto

material de friccion discrasias torrente sanguineo

tomar una vez que la conducta de vida, asi como ideacion material de friccion

Material convulsiones devolucion de friccion

Material posicion epileptico friccion

fallecimiento inesperado inusual dentro de material de friccion de la epilepsia

Negativa Efectos indicaciones son dependen de la medicacion que pueda estar utilizando, pero, ademas, confiar en su condicion de bienestar y otros aspectos.

Labileno (Lamictal) Contraindicaciones

Por lo general no reciben Labileno en caso de que son sensibles con el fin de elementos Labileno.

Tenga cuidado junto con Labileno en caso de que usted esta esperando, van a quedar embarazada, y / o en periodo de lactancia.

Tenga cuidado junto con Labileno en el caso de los diversos tipos de utilizacion de anticonceptivos, incapacidad hepatica, discapacidad suprarrenal.

Puede ser danino para evitar el uso de Labileno de repente.

Labileno (Lamictal) Preguntas comunes

Queen: ?Que es exactamente se utiliza para Labileno?

El: Labileno es realmente una medicina senalo en relacion con el tratamiento complementario con respecto a la infancia utilizando los tipos de convulsiones posteriores: incompleto convulsiones. principal general, tonico-clonicas convulsiones. en general convulsiones asociado con sintomas de Lennox-Gastaut; monoterapia con respecto a madurar a lo largo de los enfermos con incompletos convulsiones que estan recibiendo, ademas, su propia terapia junto con la carbamazepina, fenitoina, fenobarbital, primidona, asi como valproato; bipolar terapia grupos de apoyo con respecto a los adultos. Labileno le ayuda a manejar los ataques de sentimientos ( trastornos depresivos. odio, hipomania y episodios combinados).A

Reina: ?Como pueden realmente funcionar Labileno?

El: El sistema actual de sigue siendo un impacto asociado con las estaciones de sal. Labileno mantiene lejos estaciones de sal, por tanto, que respaldan las paredes de ansiedad, asi como hereupon regulan presinaptica todo eso lanzamiento asociado con excitatorio proteins. A

Reina: ?Sabe usted la asociada con sobredosis?

El: Asociado con la sobredosis suelen ser ataxia, nistagmus, la mejora de las convulsiones, disminucion de grado de conciencia, coma, fianza intraventricular mantener off. A

Queen: he saltado la dosis real asociado con Labileno. Exactamente ?que debo realizar?

El: En el caso de la dosis carente de lo necesario para el fin de la pildora tan pronto como sea posible. Por lo general, no reciben doble dosis. Y cuando lo que realmente es el tiempo mas afortunado para la dosis que necesita para llevar a cabo su propia rutina normal asociada con Labileno using. A

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Trimetoprim Sulfa, Trimetoprim Sulfa

Sulfamethoxazole/ trimethoprim

Treating infections caused by certain bacteria.

Sulfamethoxazole/trimethoprim is an antibiotic combination containing a sulfonamide antibiotic. It works by killing sensitive bacteria.

Do NOT use sulfamethoxazole/ trimethoprim if:

you are allergic to any ingredient in sulfamethoxazole/trimethoprim or to any other sulfonamide (sulfa) medicine (eg, glipizide, hydrochlorothiazide)

you have a history of low blood platelet levels (immune thrombocytopenia) caused by trimethoprim or a sulfa medicine

you have liver damage or severe kidney problems

you have anemia caused by low levels of folate in the blood

the patient is a child younger than 2 months old

you are taking dofetilide or methenamine

Contact your doctor or health care provider right away if any of these apply to you.

Before using sulfamethoxazole/ trimethoprim:

Some medical conditions may interact with sulfamethoxazole/trimethoprim. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have liver or kidney problems, certain blood problems (eg, anemia, porphyria), thyroid problems, asthma, glucose-6-phosphate dehydrogenase (G6PD) deficiency, or HIV infection

if you have low levels of folate in the blood or are at risk for low blood folate levels (eg, you have alcoholism, you are elderly, you do not absorb nutrients from food properly, you are in a poor nutritional state, you are taking medicine for seizures)

if you have a history of high blood potassium levels

Some MEDICINES MAY INTERACT with sulfamethoxazole/trimethoprim. Tell your health care provider if you are taking any other medicines, especially any of the following:

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), diuretics (eg, hydrochlorothiazide), or indomethacin because they may increase the risk of sulfamethoxazole/trimethoprim's side effects

Anticoagulants (eg, warfarin) because the risk of bleeding may be increased

Dofetilide because the risk of its side effects, including severe irregular heartbeat, may be increased by sulfamethoxazole/trimethoprim

Pyrimethamine because it is possible that a certain type of anemia may develop

Methenamine because certain urinary problems may occur

Amantadine, digoxin, hydantoins (eg, phenytoin), methotrexate, sulfones (eg, dapsone), or oral medicine for diabetes (eg, glipizide, metformin, pioglitazone) because the risk of their side effects may be increased by sulfamethoxazole/trimethoprim

Tricyclic antidepressants (eg, amitriptyline) because their effectiveness may be decreased by sulfamethoxazole/trimethoprim

Cyclosporine because its effectiveness may be decreased and the risk of kidney side effects may be increased by sulfamethoxazole/trimethoprim

This may not be a complete list of all interactions that may occur. Ask your health care provider if sulfamethoxazole/trimethoprim may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use sulfamethoxazole/ trimethoprim:

Use sulfamethoxazole/trimethoprim as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Sulfamethoxazole/trimethoprim is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using sulfamethoxazole/trimethoprim at home, a health care provider will teach you how to use it. Be sure you understand how to use sulfamethoxazole/trimethoprim. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

Do not use sulfamethoxazole/trimethoprim if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

To clear up your infection completely, use sulfamethoxazole/trimethoprim for the full course of treatment. Keep using it even if you feel better in a few days.

If you miss a dose of sulfamethoxazole/trimethoprim, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use sulfamethoxazole/trimethoprim.

Important safety information:

Sulfamethoxazole/trimethoprim may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to sulfamethoxazole/trimethoprim. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Mild diarrhea is common with antibiotic use. However, a more serious and sometimes fatal form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Be sure to use sulfamethoxazole/trimethoprim for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Sulfamethoxazole/trimethoprim only works against bacteria; it does not treat viral infections (eg, the common cold).

Long-term or repeated use of sulfamethoxazole/trimethoprim may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

Severe and sometimes fatal liver problems have happened in patients taking sulfamethoxazole/trimethoprim. Tell your doctor right away if you develop symptoms of liver problems (eg, dark urine; pale stools; severe or persistent nausea or vomiting, loss of appetite, or stomach pain; unusual tiredness; yellowing of skin or eyes).

Serious and sometimes fatal blood problems may happen. Contact your doctor immediately if you develop fever, chills, or sore throat; joint pain; pale skin; unusual bruising or bleeding; or unusual tiredness or weakness.

Sulfamethoxazole/trimethoprim may cause serious lung problems. Tell your doctor right away if you develop a cough, shortness of breath, or chest pain.

Patients taking sulfamethoxazole/trimethoprim to treat a certain type of pneumonia should avoid taking leucovorin. It may decrease sulfamethoxazole/trimethoprim's effectiveness. Talk with your doctor if you are taking leucovorin.

Do not receive a live vaccine (eg, measles, mumps) while you are taking sulfamethoxazole/trimethoprim. Talk with your doctor before you receive any vaccine.

Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients (eg, asthma patients). If you have ever had an allergic reaction to sulfites, ask your pharmacist if your product has sulfites in it.

Diabetes patients - Sulfamethoxazole/trimethoprim may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Sulfamethoxazole/trimethoprim may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using sulfamethoxazole/trimethoprim.

Lab tests, including complete blood cell counts, blood potassium levels, and kidney function, may be performed while you use sulfamethoxazole/trimethoprim. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use sulfamethoxazole/trimethoprim with caution in the ELDERLY; they may be more sensitive to its effects, especially severe skin reactions, bone marrow problems, or high blood potassium levels.

Sulfamethoxazole/trimethoprim should not be used in CHILDREN younger than 2 months old; safety and effectiveness in these children have not been confirmed.

Sulfamethoxazole/trimethoprim has benzyl alcohol in it. Do not use it in NEWBORNS or INFANTS. It may cause serious and sometimes fatal nervous system problems and other side effects.

PREGNANCY and BREAST-FEEDING: Sulfamethoxazole/trimethoprim may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using sulfamethoxazole/trimethoprim while you are pregnant. Sulfamethoxazole/trimethoprim is found in breast milk. If you are or will be breast-feeding while you use sulfamethoxazole/trimethoprim, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of sulfamethoxazole/ trimethoprim:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; mild diarrhea; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); bloody or black, tarry stools; change in the amount of urine produced; confusion; decreased urination; fast or irregular heartbeat; hallucinations; joint or muscle pain; lower back or flank pain; mental or mood changes (eg, depression); pain, redness, or swelling at the injection site; painful or stiff neck; purple patches under the skin; seizures; severe or persistent diarrhea; severe or persistent headache; severe or persistent nausea or vomiting; severe stomach or back pain (with or without nausea or vomiting); stomach cramps; swelling or soreness of the mouth or tongue; symptoms of low blood sugar (eg, increased sweating, weakness, tremors, dizziness, fainting, drowsiness, headache, chills, fast heartbeat, vision changes, increased hunger); vaginal irritation or discharge; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately.

Proper storage of sulfamethoxazole/trimethoprim:

Sulfamethoxazole/trimethoprim is usually handled and stored by a health care provider. If you are using sulfamethoxazole/trimethoprim at home, store sulfamethoxazole/trimethoprim as directed by your pharmacist or health care provider. Keep sulfamethoxazole/trimethoprim out of the reach of children and away from pets.

General information:

If you have any questions about sulfamethoxazole/trimethoprim, please talk with your doctor, pharmacist, or other health care provider.

Sulfamethoxazole/trimethoprim is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take sulfamethoxazole/trimethoprim or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about sulfamethoxazole/trimethoprim. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to sulfamethoxazole/trimethoprim. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using sulfamethoxazole/trimethoprim.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about sulfamethoxazole/trimethoprim

sulfamethoxazole and trimethoprim, Bactrim, Bactrim DS

GENERIC NAMES: Sulfamethoxazole and trimethoprim; cotrimoxazole

BRAND NAMES: Bactrim, Bactrim DS, Sulfatrim Pediatric

DISCONTINUED BRAND: Septra, Septra DS

GENERIC AVAILABLE: Yes

USES: Sulfamethoxazole/trimethoprim is used for treating infections due to susceptible bacteria. Examples include urinary tract infections, flares of chromic bronchitis due to bacteria, middle ear infections, for prevention of infections due to pneumococcus in organ transplant recipients, for the treatment or prevention of Pneumocystis carinii pneumonia. chancroid. and prevention of toxoplasma encephalitis in patients with AIDS.

Other side effects include:

MORE SERIOUS SIDE EFFECTS: Sulfamethoxazole/trimethoprim should be stopped at the first appearance of a skin rash before the rash becomes severe. Serious rashes include Stevens-Johnson syndrome (aching joints and muscles; redness, blistering, and peeling of the skin); toxic epidermal necrolysis (difficulty in swallowing; peeling, redness, loosening, and blistering of the skin).

Sulfamethoxazole/trimethoprim therapy also can cause extensive sunburn. following exposure to sunlight. Patients receiving Sulfamethoxazole/trimethoprim should avoid excessive exposure to sunlight (photosensitivity to drugs ) and should wear sunscreen.

Sulfamethoxazole/trimethoprim may form crystals in the urine which may damage the kidney and cause bleeding into the urine. It is important to drink additional liquids during therapy to prevent these side effects.

Medically Reviewed by a Doctor on 7/13/2016

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Actoplus Met (Pioglitazone/Metformin)

Actoplus Met is used for treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.

Use Actoplus Met as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with Actoplus Met. Talk to your pharmacist if you have questions about this information. Take Actoplus Met by mouth with meals. Take Actoplus Met on a regular schedule to get the most benefit from it. Taking Actoplus Met at the same times each day will help you remember to take it. Continue to take Actoplus Met even if you feel well. Do not miss any doses.

Drug Class and Mechanism

Actoplus Met is a biguanide and thiazolidinedione antidiabetic combination. It works by decreasing the amount of sugar the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.

If you miss a dose of Actoplus Met. take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store this medicine at room temperature at 77 degrees F (25 degrees C) in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted.

Do NOT use Actoplus Met if: you are allergic to any ingredient in Actoplus Met you have type 1 diabetes you have moderate to severe heart failure you have a severe infection, low blood oxygen levels, kidney or liver problems, or high blood ketone or acid levels (eg, diabetic ketoacidosis), or you are severely dehydrated you have had a stroke or a recent heart attack, or you are in shock you are 80 years old or more and have not had a kidney function test you will be having surgery or certain lab procedures you have a history of liver problems, including jaundice (yellowing of the skin or eyes), during therapy with a similar medicine called troglitazone

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Actoplus Met. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of heart problems (eg, heart failure), abnormal liver function tests, lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, eye or vision problems (eg, macular degeneration), bladder cancer, or lactic acidosis if you have fluid retention or swelling problems, vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B12 levels, or anemia, or if you are dehydrated if you have an infection, fever, recent injury, or moderate to severe burns if you have a history of bone fracture, weak bones (eg, osteoporosis), or low calcium intake if you drink alcohol or have a history of alcohol abuse if you will be having surgery or certain lab procedures if you take a beta-blocker (eg, propranolol) Some MEDICINES MAY INTERACT with Actoplus Met. Tell your health care provider if you are taking any other medicines, especially any of the following: Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin because they may increase the risk of Actoplus Met 's side effects Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), insulin, isoniazid, nicotinic acid, oral antidiabetics (eg, glipizide), phenothiazines (eg, chlorpromazine), phenytoin, sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the risk of high or low blood sugar may be increased Gemfibrozil because it may increase the risk of Actoplus Met 's side effects Rifampin because it may decrease Actoplus Met 's effectiveness, resulting in high blood sugar Anticoagulants (eg, warfarin) because their effectiveness may be decreased or the risk of their side effects may be increased by Actoplus Met

Possible Side Effects

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Cold-like symptoms; diarrhea; headache; indigestion; mild weight gain; nausea; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; bone pain; chest pain or discomfort; dark urine; difficult or painful urination; dizziness or lightheadedness; fainting; fast or difficult breathing; feeling of being unusually cold; general feeling of being unwell; muscle pain or weakness; pale stools; persistent loss of appetite; severe or persistent headache, nausea, or vomiting; shortness of breath; slow or irregular heartbeat; sudden unexplained weight gain; swelling of the hands, ankles, or feet; unusual stomach pain or discomfort; unusual drowsiness; unusual tiredness or weakness; yellowing of the eyes or skin.

If you have any questions about Actoplus Met. please talk with your doctor, pharmacist, or other health care provider. Actoplus Met is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. If using Actoplus Met for an extended period of time, obtain refills before your supply runs out.



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Clarithromycin ist ein Medikament gegen bakterielle Infektionen und fallt unter die Kategorie Makrolid-Antibiotika. Clarithromycin wird bei folgenden bakteriellen Infektionen eingesetzt: obere und untere Atemwege, ampoule Hals-Nase-Ohren, Haut (z. B. Wundrose), sowie in Kombination mit einem Magensaureblocker (Protonenpumpen-Hemmer) und einem weiteren Antibiotikum zur Beseitigung des Erregers Helicobacter pylori, dem Erreger von Magen-Darm-Geschwuren. Weiterlesen →

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Parkinson Disease - Other Medications - Parkinson Disease Health Information - Ny Times Health, Move

Parkinson Disease

In-Depth From A. D.A. M. Other Medications

Monoamine Oxidase B (MAO-B) Inhibitors

Selegiline (Eldepryl, Movergan, Zelepar), also known as deprenyl, is an antioxidant drug that blocks monoamine oxidase B (MAO-B), an enzyme that degrades dopamine. Until recently, selegiline was commonly used in early-onset disease and in combination with levodopa for maintenance. Concerns over significant side effects have been raised, however.

A newer MAO-B inhibitor, rasagiline (Azilect), is used alone during early-stage PD and in combination with L-dopa for moderate-to-advanced PD. Unlike selegiline, which is taken twice a day, rasagiline is taken once a day.

Side Effects. MAO-B inhibitors may have severe side effects:

One of the most important side effects is orthostatic hypotension, particularly in people taking Sinemet plus selegiline. This condition is a sudden drop in blood pressure that causes dizziness and lightheadedness when a patient stands up. Orthostatic hypotension can also occur with other Parkinson's drugs.

Can cause high blood pressure (hypertension) if combined with drugs that increase serotonin levels -- such drugs include nearly every major antidepressant. Patients suffering from depression and taking selegiline should discuss all treatment options with their doctor.

Can also cause a dangerous increase in blood pressure if patients eat foods rich in the amino acid tyramine. While taking selegiline or rasagiline and for 2 weeks after stopping medication, patients should avoid foods such as aged cheeses, processed lunch meats, pickled herring, yeast extract, aged red wines, draft beers, sauerkraut, and soy sauce.

Debate over Mortality Rates. Some major studies have reported higher mortality rates in patients with advanced PD. Such findings may be due to adverse effects on the heart and blood vessels. Although other studies have not reported lower survival rates, some doctors believe that, given its modest effects, selegiline may be a poorer drug choice than others, particularly in patients with risk factors for heart disease.

Dopamine Agonists

Dopamine agonists stimulate dopamine receptors in the substantia nigra, the part of the brain in which Parkinson's is thought to originate. Dopamine agonists are effective in delaying motor complications during the first 1 or 2 years of treatment.

Newer Dopamine Agonists. The most commonly prescribed dopamine agonists are pramipexole (Mirapex) and ropinirole (Requip). They are used either alone or in combination with L-dopa. Pramipexole appears to work better and have fewer side effects than ropinirole.

Recent research suggests that L-dopa is better at improving motor disability and dopamine agonists are better at reducing motor complications. L-dopa has a higher risk for dyskinesia side effects than dopamine agonists, but dyskinesia (difficulty controlling muscle movements) can also occur with dopamine agonists. There is debate about the value of dopamine agonists as initial therapy for Parkinson’s disease. Recent research suggests that early treatment with dopamine agonists may not provide any long-term advantages compared with starting treatment with L-dopa.

Side Effects. Side effects of pramipexole and ropinirole vary but can be severe and include:

Gastrointestinal side effects (nausea and constipation). Nausea can be controlled by drugs, such as domperidone.

Headache

Orthostatic hypotension (sudden drop in blood pressure upon standing up)

Nasal congestion

Nightmares, hallucinations, and psychosis (more severe than with L-dopa for both drugs)

Sudden sleep attacks. These can be very serious, particularly if patients are driving.

Other Dopamine Agonists.

Specific dopamine agonists that contain ergot alkaloids include bromocriptine (Parodel), pergolide (Permax), cabergoline (Dostinex), and lisuride (Dopergin). Bromocriptine is the only ergot dopamine agonist approved for Parkinson's treatment in the United States. Pergolide and cabergoline have been found to be associated with heart valve damage and are not used in the U. S.

Apomorphine is a dopamine agonist used as a "rescue" drug in people having on-off effects severe enough to require going off L-dopa for a few days. It is FDA-approved for treating off-time episodes of Parkinson's disease. Apomorphine is given by injection. Because it causes severe nausea and vomiting, it must be taken with an anti-nausea drug.

Catechol-O-Methyl Transferase (COMT) Inhibitors

Catechol-O-methyl transferase (COMT) inhibitors increase concentrations of existing dopamine in the brain. Entacapone (Comtan, Stalevo) is the current standard COMT inhibitor. (Stalevo combines entacapone and levodopa into a single pill.) It improves motor fluctuations related to the wearing-off effect and has shown good results in improving on time and reducing the requirements for L-dopa. If the patient does not respond to the drug within 3 weeks, it should be withdrawn. No one should withdraw abruptly from these drugs.

Side Effects. Side effects include:

Involuntary muscle movements

Mental confusion and hallucinations

Cramps, nausea, and vomiting

Insomnia

Headache

Urine discoloration (a harmless side effect but should be reported to the doctor)

Diarrhea

Less commonly, constipation, susceptibility to respiratory infection, sweating, dry mouth

Of major concern are reports of a few deaths from liver damage in patients taking the COMT inhibitor tolcapone (Tasmar). The drug has been taken off the market in many countries and is recommended in the U. S. only for patients who cannot tolerate other drugs. Entacapone does not appear to have the same effects on the liver and does not require monitoring. Still, patients should watch out for symptoms of liver damage, including jaundice (yellowish skin), fatigue, and loss of appetite.

Jaundice is a condition produced when excess amounts of bilirubin circulating in the bloodstream dissolve in the subcutaneous fat (the layer of fat just beneath the skin), causing a yellowish appearance of the skin and the whites of the eyes. With the exception of normal newborn jaundice in the first week of life, all other jaundice indicates overload or damage to the liver, or inability to move bilirubin from the liver through the biliary tract to the gut.

Anticholinergic Drugs

Anticholinergics were the first drugs used for PD, but have largely been replaced by dopamine drugs. They are generally used only to control tremor in the early stages. They are not as effective against bradykinesia and posture problems and may increase the risk for dementia in late stages. Among the many anticholinergics are trihexyphenidyl (Artane, Trihexy), benztropine (Cogentin), biperiden (Akineton), procyclidine (Kemadrin), and ethopropazine (Parisdol). Orphenadrine (Norflex) is a drug with anticholinergic properties, but is also a muscle relaxant and does not cause urinary retention.

Side Effects. Anticholinergics commonly cause dryness of the mouth (which can actually be an advantage in some people who experience drooling). Other side effects are nausea, urinary retention, blurred vision, and constipation. These drugs can also increase heart rate and worsen constipation. Anticholinergics can sometimes cause significant mental problems, including memory loss, confusion, and even hallucinations. People with glaucoma should use these drugs cautiously.

Amantadine

Amantadine (Symadine, Symmetrel) stimulates the release of dopamine and may be used for patients with early mild symptoms. It has some benefit against muscle rigidity and slowness and may help some patients in advanced stages who are unresponsive to other drugs. It is less powerful than levodopa and may lose its effectiveness after 6 months. It may also reduce motor fluctuations brought on by levodopa, however, and these benefits appear to persist for at least a year. Large, well-conducted studies are still needed to determine its true benefits and safety.

Side Effects. Side effects are similar to those of anticholinergic drugs and also may include swollen ankles and mottled skin. It can also cause visual hallucinations. Overdose can cause serious and even life-threatening toxicity. Patients with Parkinson's should not withdraw from this drug abruptly. In rare instances, it can cause acute delirium or a life-threatening condition called neuroleptic malignant syndrome.

More Information on This Topic

Review Date: 9/16/2013 Reviewed By: Harvey Simon, MD, Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A. D.A. M. Inc.

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