Official Site, Aeknil

Welcome to the AEKNIL website!

AEKNIL is widely used as an effective remedy for reducing fevers and relieving mild-to-moderate pain. AEKNIL has been prescribed by doctors for over 50 years and has established itself as a trusted brand among healthcare professionals in India and abroad.

AEKNIL Injection, a pioneer R&D product developed by Therapeutic Pharmaceuticals, is the first Paracetamol solution for Injection in the world and has been used by medical practictioners since 1968.

Numerous clinical trials and pharmacokinetic studies have been performed on AEKNIL range of products over a span of 40 years at multiple sites in India, Middle-East, South-East Asia and Africa.

These trials have confirmed the quality, safety, and efficacy profile of AEKNIL products and have made it a brand of choice and trust among the medical fraternity in India and around the world.

The active ingredient in AEKNIL is Paracetamol (USAN: Acetaminophen). It is used to reduce fevers and relieve headaches and other minor aches and pains.

Paracetamol is a major ingredient in numerous cold and flu remedies. Paracetamol can also be used in combination with opioid analgesics in management of more severe pain like post-surgical pain.

Paracetamol Injection, Aeknil

Fast and Effective.

AEKNIL Injection can be given directly by I. V. at recommended doses or can be given with any existing I. V. line as a maintenance dose as it does not interfere or react with normal saline or glucose. It is by far the most economical presentation of any Paracetamol Injection for I. V.

Ingredients and Uses

Contains Paracetamol. For reducing fevers and relieving pain. Rx Prescription-only medicine. To be used by or under the supervision of a medical practictioner only.

Dosage

I. V Route Adults: 2 to 4 ml every 4-6 hours or as directed by the Physician. Children (> 50 kg): Upto 3 ml (450 mg) every 6 hours OR Upto 12 mg to 15 mg/kg body weight. Children (Above 12 years / > 33 kg): Upto 3 ml (450 mg) every 6 hours OR Upto 12 mg to 15 mg/kg body weight or as per Physician's discretion. Do not administer to neonates and infants.

Administration

For Intravenous Administration.

Warnings

Contains Sodium Metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life threatening or less severe asthamatic episodes in certain susceptible persons. Also contains Benzyl Alcohol as preservative. This should not be administered to neonates or infants.

Precautions

Paracetamol should be given with care to patients with impaired kidney or liver function. Do not administer other Paracetamol containing medicines concurrently.

Aeknil, Aeknil

How Aeknil works

AEKNIL (Paracetamol) is a drug with antipyretic (fever-reducing) and analgesic (pain-relieving) properties. It has a weak anti-inflammatory action as well.

Paracetamol reduces fever by inhibiting the formation and release of prostaglandins in the central nervous system and inhibiting the action of endogenous pyrogens at the hypothalamic thermoregulatory centers.

The mechanism of analgesic action of Paracetamol is not fully established. Paracetamol may produce analgesia by inhibiting prostaglandin synthesis centrally and elevating the pain threshold.

Benefits of Aeknil

AEKNIL has been in the market since 1961 and has established itself as a brand of choice and trust among healthcare professionals all over the world. Over the years, AEKNIL has evolved from a single dosage form into multiple product extensions like infusions, tablets, pediatric drops, and syrups to cater to all age groups. All products are manufactured as per cGMP guidelines and have a well-documented safety and efficacy profile.

Clinical Studies

Numerous clinical trials and pharmacokinetic studies have been performed on AEKNIL range of products over a span of 40 years at multiple sites in India, Middle-East, South-East Asia and Africa.

These trials have confirmed the quality, safety, and efficacy profile of AEKNIL products and have made it a brand of choice and trust among the medical fraternity in India and around the world.

A brief, non-exhaustive list of clinical studies with AEKNIL range of products is given below.

Clinical trials

Effect of parenteral acetaminophen on the attenuation of post-operative pain subsequent colectomy. A randomized, double-blind, clinical trial. Dr. Issabeagloo et al, Department of Pharmacology, Islamic Azad University, Tabriz, Iran. Life Science Journal 2013;10(4s)

Analgesic efficacy of AEKNIL (Paracetamol) injection in immediate post-episiotomy/perineal tear pain management. Dr. I.A. Sotande et al, Oba Ademola Maternity Centre, Nigeria. OAMCJ 2007.

Use of n-acetylparaaminophenol (Paracetamol) in parenteral form in pediatrics. Dr. Versha Modi, Department of Pediatrics, B. J.Medical College and Civil Hospital, Ahmedabad, Gujarat. Pediatric Clinics of India, July 1974.

Therapy of fever with special reference to Paracetamol: A clinical trial. Dr. Manoranjan Sahai, Department of Pediatrics, Darbhanga Medical College, Laheria Sarai, Bihar. DMCJ 1972.

Clinical trials with AEKNIL brand of Paracetamol. Dr. Lohe, Deshpande et al, G. T. Hospital, Bombay. The Bombay Hospital Journal. Vol. 9, No. 3, July 1967.

Pharmacokinetic Studies

A Pharmacokinetic study of AEKNIL (Paracetamol) Injection. Dr. Esperanza Icasas-Cabral, Philippine Heart Center, Manila, Philippines. PHCJ 1998.

Quick Links

Cong Ty Cp Du?c - Trang Thi?t B? Y T? Binh D?nh (Bidiphar), Biragan

BIRAGAN CODEIN

Thanh ph?n: - Paracetamol - Codein phosphat D?ng bao ch?: Vien nén s?i b?t Quy cach dong goi: - H?p 4 v? x 4 vien, co kem toa hu?ng d?n s? d?ng. Ch? d?nh: Cac con dau v?a ph?i ho?c d? d?i ho?c khong dap ?ng v?i cac thu?c gi?m dau ngo?i bien khac. Ch?ng ch? d?nh: - Tr? em du?i 15 kg. - Ti?u phenylcetone (do co aspartam). - Lien quan d?n paracetamol: qua m?n c?m v?i paracetamol; suy ch?c nang gan. - Lien quan d?n codeine: qua m?n c?m v?i codein; suy ho h?p, t?c ngh?n du?ng th?, con hen c?p, nguy co t?c ru?t. Li?u dung: - Ngu?i l?n (tren 15 tu?i): 1 d?n 2 vien/l?n tuy theo m?c d? dau, 1-3 l?n/ngay. - Tr? em t? 15 kg tr? len (t? 3 tu?i tr? len): 3 mg/kg/ngay chia lam 4-6 l?n. T?i da 1 mg/kg/l?n tuong duong v?i 6 mg/kg/ngay. Cach dung: - Cho vien thu?c vao m?t ly nu?c l?n, s? d?ng sau khi vien s?i b?t va tan hoan toan. - Cac l?n dung thu?c nen cach nhau it nh?t 4 gi?. - Suy th?n n?ng (thanh th?i créatinine du?i 10 ml/phut): cach kho?ng cac l?n dung thu?c it nh?t 8 gi?. Th?n tr?ng: - Th?n tr?ng khi dung thu?c cho b?nh nhan suy th?n n?ng. - Trong tru?ng h?p ph?i theo ch? d? an nh?t, c?n luu y d?n lu?ng Na co trong thu?c. Lien quan d?n codein: - Khong u?ng ru?u khi dang dung thu?c. - Tru?ng h?p tang ap l?c s? nao, dung codein co th? lam n?ng them tinh tr?ng nay. - C?n luu y cac v?n d?ng vien th? thao r?ng thu?c co ch?a ho?t ch?t co th? cho k?t qu? duong tinh xét nghi?m s? d?ng ch?t kich thich. - S? d?ng kéo dai co th? d?n d?n tinh tr?ng nghi?n thu?c. - Lai xe va di?u khi?n may moc: c?n th?n tr?ng vi thu?c co th? gay bu?n ng?. Tac d?ng khong mong mu?n: Lien quan d?n paracetamol: - Vai tru?ng h?p d? ?ng bi?u hi?n b?i cac phat ban ngoai da v?i h?ng ban ho?c m? day, c?n ph?i ngung thu?c. - R?t hi?m khi gi?m ti?u c?u. Lien quan d?n codein: - ? li?u di?u tr?: co th? gay tao bon, bu?n ng?, chong m?t, bu?n non, non, co th?t ph? qu?n, d? ?ng da, ?c ch? ho h?p. - Qua li?u di?u tr?: co nguy co gay l? thu?c thu?c va xu?t hi?n h?i ch?ng cai nghi?n khi ngung thu?c d?t ng?t. H?n dung: 36 thang B?o qu?n: Du?i 30?C, tranh ?m.

S? lu?t truy c?p: 930544

BIRAGAN 500

THANH PH?N: Paracetamol. 500 mg Ta du?c v?a d?. 1 vien D?NG BAO CH?: Vien nén bao phim

QUY CACH DONG GOI: H?p 6 v? x 8 vien. H?p 10 v? x 10 vien.

CH? D?NH: - Gi?m dau, h? s?t. - Dung trong tru?ng h?p nh?c d?u, dau rang, c?m s?t.

CH?NG CH? D?NH: - Ngu?i b?nh nhi?u l?n thi?u mau ho?c co b?nh tim, ph?i, th?n ho?c gan. - Ngu?i b?nh qua m?n c?m v?i Paracetamol. - Ngu?i b?nh thi?u h?t G6PD.

LI?U DUNG – CACH DUNG: - Tr? em tren 11 tu?i va ngu?i l?n: U?ng ? - 1 vien/ l?n, 3 - 4 l?n/ngay. - Khong du?c dung paracetamol d? t? di?u tr? gi?m dau qua 10 ngay ? ngu?i l?n ho?c 5 ngay ? tr? em, tr? khi do th?y thu?c hu?ng d?n. - Khong dung paracetamol cho ngu?i l?n va tr? em d? t? di?u tr? s?t cao (tren 39,50C), s?t kéo dai tren 3 ngay. - D? gi?m thi?u nguy co qua li?u, khong nen cho tr? em qua 5 li?u paracetamol d? gi?m dau ho?c h? s?t trong vong 24 gi?, tr? khi do th?y thu?c hu?ng d?n.

TH?N TR?NG: - Paracetamol tuong d?i khong d?c v?i li?u di?u tr?. - Ph?i dung Paracetamol th?n tr?ng ? ngu?i b?nh co thi?u mau t? tru?c. - U?ng nhi?u ru?u co th? gay tang d?c tinh v?i gan c?a paracetamol; nen tranh ho?c h?n ch? u?ng ru?u. - Ph? n? mang thai ch? dung khi th?t c?n thi?t. Ph? n? dang cho con bu co th? dung du?c. - Khong ?nh hu?ng d?n lai xe va v?n hanh may moc.

H?N DUNG: 36 thang (k? t? ngay s?n xu?t).

B?O QU?N: Noi mat, tranh anh sang

Biocetamol 500 Tablet - 15 Tabs - Retail Pharma India, Biocetamol

Biocetamol 500 Tablet – 15 Tabs

Paracetamol has analgesic (pain reliever) and antipyretic (fever reducer) property. It is commonly used for the relief of headaches and other minor aches and pains and is a major ingredient in numerous cold and flu remedies. In combination with opioid analgesics, paracetamol can also be used in the management of more severe pain such as post-surgical pain and providing palliative care in advanced cancer patients. Though paracetamol is used to treat inflammatory pain.

Ingredients: Paracetamol 500 mg

Packing: 10 Tabs/Strip

Dosage: As directed by the physician.

Precautions: Renal or hepatic impairment, alcohol.

Side Effects: Nausea, allergic reactions, skin rashes, acute renal tubular necrosis, blood dyscrasias (thrombocytopenia), liver damage.

Storage Conditions: Store it at room temperature and in an airtight container. Keep away from light and children.

Paracold Kids, Paracold

Paracold kids

Ch? D?nh

Gi?m dau, h? s?t va tang cu?ng s?c d? khang trong cac tru?ng h?p: – S?t do chich ng?a, c?m l?nh, c?m cum, viem h?ng, viem xoang do nhi?m khu?n hay th?i ti?t,… – Dau d?u, dau tai, dau rang, m?c rang, nh? rang, dau do ch?n thuong, sau ph?u thu?t c?t amidan,…

Dong goi

H?p 24 Goi x 1,5mg Thu?c b?t s?i b?t

Cong th?c

Paracetamol. 150 mg – Vitamin C. 75 mg – Ta du?c. v?a d? 1 goi (Acid citric khan, Sodium bicarbonate, Mannitol, Saccharin, Sodium benzoate, Povidone, Mau Erythrosin dye, Mau Violet dye, B?t huong cam, Ethanol 96%, Du?ng RE)

Du?c l?c h?c

Paracetamol la thu?c gi?m dau – h? s?t khong gay nghi?n, khong ch?a salicylat, co tac d?ng gi?m dau ngo?i vi. Thu?c lam tang ngu?ng ch?u dau ? cac ch?ng nh?c d?u, dau co, dau kh?p va cac tri?u ch?ng kho ch?u khi b? c?m cum. Paracetamol lam gi?m than nhi?t ? ngu?i b?nh s?t, nhung hi?m khi lam gi?m than nhi?t ? ngu?i binh thu?ng. Thu?c tac d?ng len vung du?i d?i gay h? nhi?t, t?a nhi?t tang do gian m?ch va tang luu lu?ng mau ngo?i bien. – Vitamin C tham gia vao cac qua trinh chuy?n hoa, t?ng h?p cac ch?t c?n thi?t cho co th? va gi? vai tro quan tr?ng trong tang cu?ng ch?c nang mi?n d?ch, tang kh? nang d? khang v?i nhi?m khu?n c?a co th?. PARACOLD KIDS ch?a 150 mg Paracetamol va 75 mg Vitamn C, du?c bao ch? du?i d?ng thu?c b?t s?i b?t, hoa tan trong nu?c tru?c khi u?ng, thich h?p dung h? s?t – gi?m dau – tang cu?ng s?c d? khang cho tr? em.

Du?c d?ng h?c

? Paracetamol: H?p thu nhanh chong va h?u nhu hoan toan qua du?ng tieu hoa. N?ng d? d?nh trong huy?t tuong d?t trong vong 30 – 60 phut sau khi u?ng v?i li?u di?u tr?. Phan b? nhanh va d?ng d?u trong ph?n l?n cac mo c?a co th?, qua du?c nhau thai va s?a m?. Kho?ng 25% Paracetamol trong mau k?t h?p v?i protein huy?t tuong. Th?i gian ban th?i t? 1 – 3 gi?. Paracetamol chuy?n hoa ? gan thanh ch?t trung gian N – acetyl – benzoquinonimin co th? gay d?c gan. Thu?c dao th?i ch? y?u theo du?ng ti?u trong vong 24 gi? du?i d?ng s?n ph?m chuy?n hoa (ch? m?t lu?ng nh? ? d?ng khong d?i). ? Vitamin C: H?p thu d? dang sau khi u?ng va phan b? r?ng rai trong cac mo co th?. Kho?ng 25% Vitamin C trong huy?t tuong k?t h?p v?i protein. Vitamin C oxy – hoa thu?n ngh?ch thanh acid dehydroascorbic. M?t it Vitamin C chuy?n hoa thanh nh?ng h?p ch?t khong co ho?t tinh g?m Ascorbic acid – 2– sulfat va acid oxalic du?c bai ti?t trong nu?c ti?u. Lu?ng Vitamin C vu?t qua nhu c?u c?a co th? cung du?c nhanh chong dao th?i ra nu?c ti?u du?i d?ng khong bi?n d?i.

Ch?ng ch? d?nh

– M?n c?m v?i Paracetamol. – Ngu?i b?nh nhi?u l?n thi?u mau ho?c co b?nh tim, ph?i, th?n, suy gan. – Ngu?i b?nh thi?u h?t glucose – 6– phosphate dehydrogenase. – Ngu?i co ti?n s? s?i th?n, tang oxalat ni?u va lo?n chuy?n hoa oxalat, b?nh thalassemia.

Tac d?ng ph?

– Hi?m g?p cac tai bi?n d? ?ng nhu ban d?, n?i m? day. Ngung dung thu?c khi th?y xu?t hi?n cac bi?u hi?n nay. – Dung li?u cao va keo dai co th? gay t?n thuong ? gan. – Vai tru?ng h?p hi?m th?y gi?m ti?u c?u. – Li?u cao Vitamin C co th? gay tieu ch?y, bu?n non, non, ? nong, nh?c d?u, m?t ng?, tang oxalat ni?u, thi?u mau tan huy?t. Thong bao cho bac s? nh?ng tac d?ng khong mong mu?n g?p ph?i khi s? d?ng thu?c. QUA LI?U: – Qua li?u Paracetamol co th? do dung m?t li?u cao duy nh?t, ho?c do u?ng l?p l?i li?u cao Paracetamol (7,5 – 10g m?i ngay, trong 1 – 2 ngay), ho?c do u?ng thu?c dai ngay. Ho?i t? gan la tac d?ng d?c c?p tinh nghiem tr?ng nh?t do qua li?u va co th? gay t? vong. Bu?n non, non va dau b?ng thu?ng x?y ra trong vong 2 – 3 gi? sau khi u?ng li?u cao c?a thu?c. Qua li?u Vitamin C gay s?i th?n, bu?n non, viem d? day va tieu ch?y. – X? ly: + C?n r?a d? day trong m?i tru?ng h?p, t?t nh?t trong vong 4 gi? sau khi u?ng va di?u tr? h? tr? tich c?c. + S? d?ng thu?c gi?i d?c: N – acetylcystein, Methionin. + Ngoai ra co th? dung than ho?t va/ho?c thu?c t?y mu?i d? lam gi?m h?p th? Paraceamol.

Th?n tr?ng

Paracetamol co th? gay cac ph?n ?ng tren da nghiem tr?ng nhu h?i ch?ng Steven – Jonhson (SJS), h?i ch?ng ho?i t? da nhi?m d?c (TEN) hay h?i ch?ng Lyell, h?i ch?ng ngo?i ban m?n m? toan than c?p tinh (AGEP). – Th?n tr?ng khi s? d?ng Paracetamol cho ngu?i b?nh thi?u mau t? tru?c. – Khong u?ng ru?u khi dung thu?c. – Dung Vitamin C vao bu?i t?i va li?u cao co th? gay kho ng?. – Tru?ng h?p an kieng mu?i c?n luu y thu?c co ch?a 95,1mg Na trong 1 goi. – N?u tri?u ch?ng dau dai d?ng qua 5 ngay, ho?c con s?t qua 3 ngay, ho?c thu?c chua d? hi?u qu?, ho?c th?y xu?t hi?n cac tri?u ch?ng khac, khong nen keo dai vi?c t? s? d?ng thu?c ma khong h?i y ki?n bac s?.

Tuong tac

– Isoniazid, Alcool, cac thu?c ch?ng co gi?t (Phenytoin, Barbiturat, Carbamazepin) co th? lam gia tang nguy co d?c gan gay b?i Paracetamol. – Dung chung Phenothiazin v?i Paracetamol co th? d?n d?n kh? nang gay h? s?t nghiem tr?ng. – Metoclopramid co th? lam gia tang s? h?p thu c?a Paracetamol. – Vitamin C la m?t ch?t kh? m?nh, nen ?nh hu?ng d?n nhi?u xet nghi?m d?a tren ph?n ?ng oxy hoa – kh?. S? co m?t Vitamin C trong nu?c ti?u lam tang gi? t?o lu?ng glucose n?u d?nh lu?ng b?ng thu?c th? d?ng (II) sulfat va gi?m gi? t?o lu?ng glucose n?u d?nh lu?ng b?ng phuong phap glucose oxydase.

H?n dung

2 nam k? t? ngay s?n xu?t

B?o qu?n

Noi kho (d? ?m ? 70%), nhi?t d? khong qua 30 o C, tranh anh sang

Cach dung

Hoa tan thu?c vao lu?ng nu?c (thich h?p cho be) d?n khi s?i h?t b?t. Kho?ng cach gi?a cac l?n dung thu?c t? 4 – 6 gi?, khong qua 5 l?n/ngay. Li?u thong thu?ng t? 10 – 15 mg/kg/l?n va 60 mg/kg/ngay. – Tr? em tren 3 d?n 11 thang tu?i: u?ng 1/2 goi/l?n. Ngay 3– 4 l?n. – Tr? em tren 11 thang d?n du?i 2 tu?i: u?ng 3/4 goi/l?n. Ngay 3– 4 l?n. – Tr? em t? 2 d?n 3 tu?i: u?ng 1 goi/l?n. Ngay 3– 4 l?n. – Tr? em tren 3 d?n 6 tu?i: u?ng 1,5 goi/l?n. Ngay 3– 4 l?n. – Tr? em tren 6 d?n 9 tu?i: u?ng 2 – 2,5 goi/l?n. Ngay 3– 4 l?n. – Tr? em tren 9 d?n 12 tu?i: u?ng 3 goi/l?n. Ngay 3– 4 l?n. Ho?c theo ch? d?n c?a th?y thu?c.

Tieu chu?n

G?i email

Tachidol And Co-Efferalgan, Paracetamol Codeine Combo, Co-Efferalgan

26 dic 2013 . Panadeine ( paracetamol 500 mg - codeine 8 mg) was given. M. V. Tenoxicam and parac . 26 dic 2013 . Panadeine ( paracetamol 500 mg - codeine 8 mg) was given. M. V. Tenoxicam and parac . 2g propacetamol is hydrolysed to 1g paracetamol ; salicylates. Percocet<sup>®</sup> and Tylox<sup>®</sup> in combinati . Sep 5, 2016 . Codeine or 3-methylmorphine (a naturally occurring methylated. Preparations wil. Siu Guan, Taiwan; A. C. and C ( Paracetamol and Caffeine, + Codeine ). … Actavis, Malta; Actavis U. Jun 29, 2015 . heijn paracetamol 120 mg' OR 'albert heijn paracetamol 240. ultra rapi. PARACETAMOLO + CODEINA ( Tachidol ® , CO - Efferalgan ®). … A systematic review of combination step I..

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Panagesic, Panagesic

Panagesic

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Pamabrom

Foreign Name

2-Amino-2-methylpropanol 8-bromtheophyllin (German)

Generic Names

Pamabrom (OS: USAN)

8-Bromotheophylline comp. with 2-amino-2-methyl-1-propanol (IS)

Pamabrom (PH: USP 38)

Brand Names

Ai Jia (Pamabrom and Paracetamol) Shuaike Pharmaceutical, China

Dolo-Esan Periodo Menstrual (Pamabrom and Paracetamol, + Mepyramine) Farmaceutica Esan, Chile

Gesidol Periodo (Pamabrom and Mepyramine, + Paracetamol) Mintlab Co. Chile

Maximum Strength Aqua-Ban Thompson, United States

Mensodol (Pamabrom and Paracetamol) Anthus, India

Midol PMS Complete (Pamabrom and Paracetamol, + Mepyramine) Bayer Consumer Care, Canada

Midol Teen Maximum Strength (Pamabrom and Paracetamol) Bayer HealthCare, United States

Painaid PMF (Pamabrom and Paracetamol) ZEE Medical, United States

Pamprin Maximum Pain Relief (Pamabrom and Salicylic Acid) Chattem, United States

Panadol Menstrual (Pamabrom and Paracetamol) GlaxoSmithKline, Malaysia; GlaxoSmithKline, Singapore

Panagesic Periodo Menstrual (Pamabrom and Paracetamol, + Mepyramine) Chemopharma, Chile

Predual (Pamabrom and Paracetamol, + Mepyramine) Laboratorios Andromaco, Chile

Syncol (Pamabrom and Paracetamol, + Mepyramine) Sanfer, Mexico

Syncol Teen (Pamabrom and Paracetamol (pediatric)) Sanfer, Mexico

Tapsin Periodo (Pamabrom and Mepyramine, + Paracetamol) Maver, Chile

Tylenol Menstrual Extra Strength (Pamabrom and Paracetamol, + Mepyramine) McNeil Consumer Healthcare, Canada

Womankit (Pamabrom and Paracetamol) Haya Ph. Egypt

Women's Tylenol Menstrual Relief (Pamabrom and Paracetamol) McNeil Consumer Healthcare, United States

Glossary

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Introduccion - Acetaminofen, Sintesis, Usos Y Mas, Acetaminofen

El paracetamol o acetaminofen (acetaminofeno ) presenta accion analgesica (reductora del dolor), al impedir la formacion de prostaglandinas en el organismo. Ademas, presenta accion antipiretica (reductora de la fiebre), al inhibir las prostaglandinas a nivel del centro termorregulador situado en el hipotalamo, en el cerebro. Sin embargo, no presenta accion antiinflamatoria significativa. Se utiliza, por tanto, para el tratamiento de la fiebre y el dolor moderado. Ademas, tiene efectos antipireticos. Se presenta habitualmente en forma de capsulas, comprimidos, supositorios o gotas de administracion oral.

Los nombres paracetamol y acetaminofen pertenecen a la historia de este compuesto y provienen de la nomenclatura tradicional de laquimica organica, N-acetil-para-aminofenol y para-acetil-aminofenol

1. Dart R. Erdman A. Acetaminophen Poisoning: an Evidence-Based Consensus Guideline for Out-of-Hospital Management. Clinical Toxicology 2006, 44:1; 1- 18.

4. Wallace CI, Dargan PI, Jones AL. Paracetamol overdose: an evidence based flowchart to guide management. Emerg Med J 2002; 19: 202-205

5.Manual de intoxicaciones Capitulo 8 Intoxicacion por paracetamol Autor: C. Luaces i Cubells, A. Noguera Julian

Panodil, Panodil

paracetamol

paracetamol

An over-the-counter analgesic used for headaches, muscle or joint pain, and fever, which lacks anti-inflammatory activity.

Therapeutic range 10–25 mg/L

Critical value ≥ 300 mg/L

Toxicology Overdose can cause fatal liver failure. Up to 10% of hospitalisations for overdose and 40% of acute hepatic failure are linked to paracetamol overdose, which is more often accidental—e. g. children, alcoholics—than suicidal. Doses of > 150 mg/kg/24 hours cause acute liver failure.

Clinical stage of paracetamol toxicity 1. 1–24 hours—Non-specific. 2. 24–48 hours—Right upper quadrant pain, tenderness with elevated liver enzymes. 3. 72–96 hours—Marked increase in liver enzymes; fulminant hepatic failure, coagulopathy, acidosis. 4. 4–14 days—Liver recuperates or patient dies.

Pathogenesis of paracetamol overdose 90% is metabolised in the liver to non-toxic glucuronide and sulphate conjugates; 5% is oxidised by cytochrome p450 to NAPQI, which covalently binds to hepatocyte macromolecules, leading to hepatocyte death; 5% is excreted unchanged in urine.

paracetamol

A drug widely used to relieve pain and reduce fever. The drug does not irritate the stomach, as ASPIRIN does, but overdose causes liver and kidney damage and may cause death from liver failure. 15 g or more is potentially serious. The victim remains well for a day or two and liver failure develops between the third and fifth day. The drug is on the WHO official list. Brand names are Alvedon, Calpol Disprol Paediatric, Infadrops, Medinol and Salzone. Preparations that include paracetamol include Cosalgesic, Distalgesic, Domperamol, Fortagesic, Kapake, Midrid, Migraleve, Paradote, Paramax, Remedeine and Solpadol. acetaminophen; N - acetyl - p - aminophenol; paracetamol a non-opioid analgesic with little or no anti-inflammatory action; first-line painkiller of choice; used with care in patients with hepatic or renal impairment, or alcohol dependency, or those taking metoclopramide; overdose causes severe liver damage and death; recommended adult dose: daily maximum of 4 g (i. e. 8 × 500 mg tablets) ( see Table 1 )

Table 1: Principles of pain management

Examples of drug

Paracetamolum, Paracetamolum

paracetamol

paracetamol

An over-the-counter analgesic used for headaches, muscle or joint pain, and fever, which lacks anti-inflammatory activity.

Therapeutic range 10–25 mg/L

Critical value ≥ 300 mg/L

Toxicology Overdose can cause fatal liver failure. Up to 10% of hospitalisations for overdose and 40% of acute hepatic failure are linked to paracetamol overdose, which is more often accidental—e. g. children, alcoholics—than suicidal. Doses of > 150 mg/kg/24 hours cause acute liver failure.

Clinical stage of paracetamol toxicity 1. 1–24 hours—Non-specific. 2. 24–48 hours—Right upper quadrant pain, tenderness with elevated liver enzymes. 3. 72–96 hours—Marked increase in liver enzymes; fulminant hepatic failure, coagulopathy, acidosis. 4. 4–14 days—Liver recuperates or patient dies.

Pathogenesis of paracetamol overdose 90% is metabolised in the liver to non-toxic glucuronide and sulphate conjugates; 5% is oxidised by cytochrome p450 to NAPQI, which covalently binds to hepatocyte macromolecules, leading to hepatocyte death; 5% is excreted unchanged in urine.

paracetamol

A drug widely used to relieve pain and reduce fever. The drug does not irritate the stomach, as ASPIRIN does, but overdose causes liver and kidney damage and may cause death from liver failure. 15 g or more is potentially serious. The victim remains well for a day or two and liver failure develops between the third and fifth day. The drug is on the WHO official list. Brand names are Alvedon, Calpol Disprol Paediatric, Infadrops, Medinol and Salzone. Preparations that include paracetamol include Cosalgesic, Distalgesic, Domperamol, Fortagesic, Kapake, Midrid, Migraleve, Paradote, Paramax, Remedeine and Solpadol. acetaminophen; N - acetyl - p - aminophenol; paracetamol a non-opioid analgesic with little or no anti-inflammatory action; first-line painkiller of choice; used with care in patients with hepatic or renal impairment, or alcohol dependency, or those taking metoclopramide; overdose causes severe liver damage and death; recommended adult dose: daily maximum of 4 g (i. e. 8 × 500 mg tablets) ( see Table 1 )

Table 1: Principles of pain management

Examples of drug

Acamoli, Acamoli

paracetamol

paracetamol

An over-the-counter analgesic used for headaches, muscle or joint pain, and fever, which lacks anti-inflammatory activity.

Therapeutic range 10–25 mg/L

Critical value ≥ 300 mg/L

Toxicology Overdose can cause fatal liver failure. Up to 10% of hospitalisations for overdose and 40% of acute hepatic failure are linked to paracetamol overdose, which is more often accidental—e. g. children, alcoholics—than suicidal. Doses of > 150 mg/kg/24 hours cause acute liver failure.

Clinical stage of paracetamol toxicity 1. 1–24 hours—Non-specific. 2. 24–48 hours—Right upper quadrant pain, tenderness with elevated liver enzymes. 3. 72–96 hours—Marked increase in liver enzymes; fulminant hepatic failure, coagulopathy, acidosis. 4. 4–14 days—Liver recuperates or patient dies.

Pathogenesis of paracetamol overdose 90% is metabolised in the liver to non-toxic glucuronide and sulphate conjugates; 5% is oxidised by cytochrome p450 to NAPQI, which covalently binds to hepatocyte macromolecules, leading to hepatocyte death; 5% is excreted unchanged in urine.

paracetamol

A drug widely used to relieve pain and reduce fever. The drug does not irritate the stomach, as ASPIRIN does, but overdose causes liver and kidney damage and may cause death from liver failure. 15 g or more is potentially serious. The victim remains well for a day or two and liver failure develops between the third and fifth day. The drug is on the WHO official list. Brand names are Alvedon, Calpol Disprol Paediatric, Infadrops, Medinol and Salzone. Preparations that include paracetamol include Cosalgesic, Distalgesic, Domperamol, Fortagesic, Kapake, Midrid, Migraleve, Paradote, Paramax, Remedeine and Solpadol. acetaminophen; N - acetyl - p - aminophenol; paracetamol a non-opioid analgesic with little or no anti-inflammatory action; first-line painkiller of choice; used with care in patients with hepatic or renal impairment, or alcohol dependency, or those taking metoclopramide; overdose causes severe liver damage and death; recommended adult dose: daily maximum of 4 g (i. e. 8 × 500 mg tablets) ( see Table 1 )

Table 1: Principles of pain management

Examples of drug

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4 марта 2015 г. в 10:18 · Доступно всем

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5 Interaction with other medicines.

Paracetamol :

Reduced absorption of cholestyramine within 1 hr of admin. Accelerated absorption with metoclopramide. Decreased effect with barbiturates, carbamazepine, hydantoins, rifampicin and sulfinpyrazone. Paracetamol may increase effect of warfarin. Potentially Fatal: Paracetamol increases the risk of liver damage in chronic alcoholics. Increased risk of toxicity with other hepatotoxic drugs or drugs which induce microsomal enzymes e. g. barbiturates, carbamazepine, hydantoins, rifampicin and sulfinpyrazone.

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Codeine 10mg, Napacod

Codeine 10mg / Acetaminophen (Paracetamol) 500mg tabs x (100) (Adco-Napacod / Co-Codamol / Painamol)

Each tablet contains: Acetaminophen / Paracetamol: 500 mg Codeine phosphate: 10 mg Nipastat: 0.185% m/m as preservative

INDICATIONS: NAPACOD is indicated for the relief of headaches, as well as other types of pain and fever.

Napacod's easy to swallow tablets are a powerful combination analgesic (pain killer) that offers fast, effective, multi-symptom relief from pain. The Napacod formula contains two main active ingredients:

Two strong analgesics (pain killers) Acetaminophen / Paracetamol and Codeine Phosphate which get straight to work on your thumping headache or pain.

Napacod is also very effective for:

Headache

Period Pain

Muscular aches and pains

Toothache

Backache

So this combination of medications is also used to effectively treat pain associated with conditions such as headache, dental pain, muscle pain, painful menstruation, pain following an accident, and pain following operations.

DOSAGE AND DIRECTIONS FOR USE

Adults: 1 - 2 tablets, repeated 4-6 hourly if necessary Children 7 - 12 years: ? - 1 tablet, repeated 6 hourly if necessary Children under 6 years: Not recommended

Do not take more than 8-10 tablets in any 24 hour period

IDENTIFICATION Pink, flat, round, bevelled edge, bisected tablets measuring ?" (12,7 mm) in diameter.

Do not use Napacod if:

You are allergic to Acetaminophen / Paracetamol or Codeine.

You are taking any other medicines containing Acetaminophen / Paracetamol or Codeine (without consulting your doctor).

You think you may be pregnant or you are breast feeding.

You suffer from alcoholism.

You suffer from severe lung disease and difficulty breathing.

You are at risk from blocked intestine

Have raised pressure within your skull

You have suffered a head injury

You have severe stomach pain

Information

Dioflam, Dioflam

Duoflam

Typical use Of Ibuprofen :

Ibuprofen Is Used For The Relief Of Mild To Moderate Pain Including Pain In The Joints And Muscles, Migraine (one-sided Headache), Dental Pain, Body Pain, Pain During The Menstrual Cycle, As Well As To Treat Fever And Symptoms Of ColdA .

Mechanism of action of Ibuprofen :

Ibuprofen Belongs To The Group Of Medicines Called Nonsteroidal Anti-inflammatory Drugs. It Is A Pain-killer That Relieves Pain By Blocking Production Of A Certain Natural Substance (prostaglandin) That Is Released In The BodyA During Pain.

Drug Interaction of Ibuprofen :

Ibuprofen Should Be Used With Caution In Combination With Drugs Such As Corticosteroids, Aspirin, Lithium Drugs, Methotrexate, Cyclosporine, Drugs Used To Treat High Blood Pressure (anti-hypertensive) Or Heart Related Problems (cardiac Glycosides), Blood Thinning Drugs (warfarin), Selective Serotonin-reuptake Inhibitors, Mifepristone, Tacrolimus, Zidovudine, And Quinolone Antibiotics. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.

Side effects of Ibuprofen :

Indigestion, Vomiting, Abdominal Pain, Heart Burn, Diarrhea, Dizziness, Skin Rashes, Sever Allergic Reactions. Heart Patients May Experience Swelling Of Body And Fluid Retention. Overdose May Cause Stomach Or Abdominal Pain And Ringing In The Ears.

INTERACTIONS OF IBUPROFEN

How Ibuprofen will impact on Pregnancy ?

Typical use Of Paracetamol :

Paracetamol Is Used For The Relief Of Mild To Moderate Pain In Conditions Such As Headache (including Migraine), Toothache, Ear Pain, Joint Pain, Pain Of Menstruation, Fever, Feverish Colds, And Flu.

Mechanism of action of Paracetamol :

Paracetamol Is Categorized As An Analgesic (painkiller) And Antipyretic (fever Reducing) Drug. Paracetamol Reduces Pain By Increasing The Pain Threshold. It Reduces Fever By Acting On The Temperature-regulating Region Of Brain, Resulting In Increased Blood Flow Across The Skin, Sweating And Heat Loss.

Drug Interaction of Paracetamol :

Cholestyramine, Metoclopramide And Domperidone May Alter The Effects Of Paracetamol. Use Of Paracetamol With Warfarin May Increase The Risk Of Bleeding. Paracetamol May Increase The Effects Of Chloramphenicol. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.

Side effects of Paracetamol :

Side Effects Of Paracetamol Are Usually Rare, And Include Allergic Reactions Such As Shortness Of Breath, Abnormalities Of Blood Cells, Skin Reddening, Blisters Or Rash, Swollen Facial Features, Or A Runny Nose. Overdose (more Than 4 G In Adults And More Than 2 G In Children) May Cause Severe Liver Damage.

INTERACTIONS OF PARACETAMOL

How Paracetamol will impact on Pregnancy ?

Information Not Available.

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