Endometrin (Progesterone) Side Effects, Interactions, Warning, Dosage & Uses, Endometrin


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DRUG DESCRIPTION

Endometrin (progesterone ) vaginal insert contains micronized progesterone. Endometrin is supplied with polyethylene vaginal applicators.

The active ingredient, progesterone, is present in 100 mg amount along with other excipients. The chemical name for progesterone is pregn-4-ene-3,20-dione. It has an empirical formula of C 21 H 30 O 2 and a molecular weight of 314.5. Progesterone exists in two polymorphic forms. The form used in Endometrin, the alpha-form, has a melting point of 127-131°C. The structural formula is:

Each Endometrin Vaginal Insert delivers 100 mg of progesterone in a base containing lactose monohydrate, polyvinylpyrrolidone, adipic acid, sodium bicarbonate, sodium lauryl sulfate, magnesium stearate, pregelatinized starch, and colloidal silicon dioxide.

What are the possible side effects of progesterone vaginal?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

sudden headache, numbness or weakness (especially on one side of the body), shortness of breath, or problems with vision, speech, or balance;

chest pain or heavy feeling, pain spreading to the arm or shoulder;

pain or swelling in one or both legs;

nausea, stomach pain, low fever, loss of appetite, dark urine.

What are the precautions when taking progesterone (Endometrin)?

Before using progesterone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of blood clots, recent stroke or heart attack (within 1 year), liver disease, cancer of the breast or other female organs, vaginal bleeding of unknown cause, a loss of pregnancy with some tissue remaining in the uterus ("missed abortion"), an abnormal pregnancy where the fertilized egg is outside of the uterus (ectopic pregnancy).

Before using this.

Last reviewed on RxList: 4/22/2013 This monograph has been modified to include the generic and brand name in many instances.