Gastrointestinal Buy Ranitidine At, Zanamet

Gastrointestinal

Ranitidine (Zanamet)

Ranitidine is used for treating certain conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It is also used to treat ulcers of the small intestine that have not responded to other treatment. It may be used as a short-term alternative to oral ranitidine, in patients who are not able to take medicine by mouth. Ranitidine is an H 2 - receptor blocker. It works by blocking the action of histamine in the stomach. This reduces the amount of acid the stomach makes. Reducing stomach acid helps to reduce heartburn, heal irritation of the esophagus, and heal ulcers of the stomach or intestines.

Use Ranitidine as directed by your doctor.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

You may take antacids while you are using Ranitidine if you are directed to do so by your doctor.

Continue to use Ranitidine even if you feel well. Do not miss any dose.

If you miss a dose of Ranitidine, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ranitidine.

Store Ranitidine between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ranitidine out of the reach of children and away from pets.

Do NOT use Ranitidine if:

you are allergic to any ingredient in Ranitidine

you have a history of the blood disease porphyria

you are taking dasatinib.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Ranitidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems

if you have abnormal blood electrolyte levels or a history of irregular heartbeat.

Some medicines may interact with Ranitidine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Certain benzodiazepines (eg, midazolam, triazolam), glipizide, procainamide, or warfarin because the risk of their side effects may be increased by Ranitidine

Dasatinib, delavirdine, gefitinib, certain HIV protease inhibitors (eg, atazanavir), itraconazole, or ketoconazole because their effectiveness may be decreased by Ranitidine.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ranitidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Ranitidine may rarely cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ranitidine with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Ranitidine may interfere with certain lab tests, including urine protein tests. Be sure your doctor and lab personnel know you are taking Ranitidine.

Lab tests, including liver function, may be performed while you use Ranitidine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Ranitidine should be used with extreme caution in children younger than 1 month old; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ranitidine while you are pregnant. Ranitidine is found in breast milk. Do not breastfeed while taking Ranitidine.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; headache; nausea; stomach upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); change in the amount of urine produced; confusion; dark urine; depression; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; severe or persistent headache or stomach pain; unusual bruising or bleeding; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Your order will be packed safely and secure and dispatched within 24 hours. This is how your parcel will look like, the images are photographs of real shipments. It has the size of a normal protected envelope and it does not disclose its contents.

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Orofar Spray 30 Ml, Orofar Lidocaine

OROFAR spray 30 ml.

OROFAR 0.2% / 0.15% Spray oromucosal contains 2 mg / ml benzoxonium chloride and 1.5 mg / ml lidocaine chloride. OROFAR 0.2% / 0.15% Spray oromucosal contains anti-inflammatory and local anesthetic agent for the treatment of diseases caused by bacteria, viruses and fungi that cause sore throat, and infections of the mouth and throat .

More info

OROFAR spray 30 ml.

What is OROFAR 0.2% / 0.15% Spray oral mucosa and what it is used OROFAR 0.2% / 0.15% Spray oromucosal contains 2 mg / ml benzoxonium chloride and 1.5 mg / ml lidocaine chloride. OROFAR 0.2% / 0.15% Spray oromucosal contains anti-inflammatory and local anesthetic agent for the treatment of diseases caused by bacteria, viruses and fungi that cause sore throat, and infections of the mouth and throat; sore throat, colds, pharyngitis or laryngitis (with or without difficulty in swallowing), small mouth ulcers (sores) and gingivitis. OROFAR 0.2% / 0.15% Spray oral mucosa can be used as a maintenance treatment for angina. OROFAR 0.2% / 0.15% oromucosal spray is indicated for the treatment of children over 4 years and older. OROFAR exists in the form of an oral spray mucosa and lozenges and does not cause irritation of the mouth and throat.

2. What you should know before using OROFAR 0.2% / 0.15% Spray Oromucosal Do not use OROFAR 0.2% / 0.15% Spray Oromucosal: if you are allergic to the active substances - quaternary ammonium compounds or lidocaine or nyakoyaot other ingredients of this medicine (listed in section 6). Warnings and Precautions OROFAR 0.2% / 0.15% oromucosal spray is not recommended to be used in children under 4 years of age. Consult your doctor if inflammation of the throat accompanied by high fever or lasts more than 5 days. OROFAR 0.2% / 0.15% oromucosal spray is intended for application to the buccal mucosa (mouth and throat). The spray should not be used if the applicator is damaged.

children OROFAR 0.2% / 0.15% oromucosal spray is not recommended to be used in children under 4 years of age.

Other medicines and OROFAR 0.2% / 0.15% Spray Oromucosal Inform your doctor or pharmacist if you are using, have recently used or might use any other medicines.

Pregnancy and lactation If you are pregnant or breast-feeding, think you may be pregnant or planning to become pregnant, talk to your doctor before taking OROFAR 0.2% / 0.15% Spray oral mucosa.

3. How to use OROFAR 0.2% / 0.15% Spray Oromucosal Always use this medicine exactly as described in the package insert or as you told your doctor or pharmacist. If you are not sure, ask your doctor or pharmacist. Apply OROFAR 0.2% / 0.15% Spray oral mucosa in the mouth or back of the oral cavity from 3 to 6 times daily. Keep OROFAR 0.2% / 0.15% oromucosal spray upright and press 4 times during each application.

Before using OROFAR 0.2% / 0.15% Spray Oromucosal: Remove the protective cap. Place the applicator on the pump and press firmly. Before initial use, activate the pump by pressing the applicator several times to the emergence of spray into the air. Applicator disinfected after use with a clean cloth moistened with a small amount of spray and then dry. In particular, the applicator should be disinfected and dried before use OROFAR 0.2% / 0.15% Spray oral mucosa of another patient. The applicator is removed after use and stored in the secondary packaging of OROFAR 0.2% / 0.15% Spray Oromucosal until further use. Use in children OROFAR 0.2% / 0.15% Spray oral mucosa can be used in children over 4 years, but the dose should be reduced. Spray only two to three times at each administration. OROFAR 0.2% / 0.15% oromucosal spray is not recommended to be used in children under 4 years of age.

If you use more than the amount OROFAR 0.2% / 0.15% Spray Oromucosal In case of accidental ingestion of large quantities of OROFAR 0.2% / 0.15% Spray Oromucosal immediately inform your doctor or pharmacist. Consult your doctor or pharmacist if you have the impression that the effect of OROFAR 0.2% / 0.15% Spray oral mucosa is too weak or the opposite - too hard.

4. Possible side effects Like all medicines OROFAR 0.2% / 0.15% Spray oral mucosa can cause side effects, although not everybody gets them. In some cases it may be a slight transient irritation at the application site. In very rare cases may experience allergic reactions such as skin rash and swelling of the face and throat. If you get any side effects, tell your doctor or pharmacist. This includes any possible effects not listed in this leaflet.

5. How to store OROFAR 0.2% / 0.15% Spray Oromucosal Keep out of the reach and sight of children. Do not use this medicine after the expiry date stated on the carton. The expiry date refers to the last day of that month. Do not store above 30 ° C. Store in the original package. Do not dispose of medications in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. Contents of the pack and other information What OROFAR 0.2% / 0.15% Spray Oromucosal The active substances are benzoxonium chloride and lidocaine hydrochloride. The other ingredients (excipients) are ethanol 94% (w / w), glycerol, peppermint oil, menthol, hydrochloric acid, purified water.

Acetylcysteine Report For Patients Like You, Pulmovent

Acetylcysteine treatment report

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This item is relevant to you: General health

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This item is relevant to you: Bronchiectasis

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What is acetylcysteine?

Acetylcysteine is a mucolytic (myoo-koe-LIT-ik) drug that breaks down mucus, the substance that lubricates many parts of the body such as the mouth, throat, and lungs.

Acetylcysteine is used to thin the mucus in people with certain lung conditions such as cystic fibrosis, emphysema, bronchitis, tuberculosis. Acetylcysteine is also used during surgery or anesthesia, and to prepare the throat or lungs for a medical test.

Acetylcysteine may also be used for purposes other than those listed in this medication guide.

Precautions

Do not use this medication if you are allergic to acetylcysteine.

Before using acetylcysteine, tell your doctor if you are allergic to any drugs, or if you have asthma. You may not be able to use acetylcysteine, or you may need dosage adjustments or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether acetylcysteine inhalation passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not mix other medicines in a nebulizer with acetylcysteine, unless your doctor has told you to.

Instructions

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of an acetylcysteine overdose are not known.

Use the medication as soon as you remember the missed dose. If it is almost time for your next dose, skip the missed dose and use the medicine at your next regularly scheduled time. Do not use extra medicine to make up the missed dose.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using acetylcysteine and call your doctor at once if you have chest tightness or trouble breathing.

Less serious side effects of acetylcysteine include:

unusual or unpleasant smell while using the medication;

sticky feeling around the nebulizer mask;

white patches or sores inside your mouth or on your lips;

nausea, vomiting;

fever;

runny nose, sore throat;

drowsiness; or

skin rash or clammy feeling.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Interactions

There may be other drugs that can affect acetylcysteine, or that should not be used in the same nebulizer. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

Acetadote, Acys-5, Mucomyst, Mucomyst-20, N-acetylcysteine, NAC, Parvolex, Parvolex (obsolete), Solgar NAC, acetylcysteine, and Mucomyst-10

Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

Last updated: September 20, 2016

What is the most important information I should know about acetylcysteine?

Do not use acetylcysteine at home if you do not fully understand all instructions that are specific to your use of this medication. Use only the inhaler device provided with your medicine or you may not get the correct dose.

Acetylcysteine solution can be inhaled directly from the nebulizer, or with a face mask, mouth piece, tent, or intermittent positive pressure breathing (IPPB) machine.

Do not mix your dose of acetylcysteine until you are ready to use the medication. Diluted acetylcysteine must be used within 1 hour of mixing.

Acetylcysteine liquid may change color once you have opened the bottle. This is caused by a chemical reaction and will not affect the medicine.

You may sense an unusual or unpleasant smell while using acetylcysteine.

Other side effects may include sticky feeling around the nebulizer mask, white patches or sores inside your mouth or on your lips, nausea, fever, runny nose, sore throat, drowsiness, skin rash, or clammy skin.

There may be other drugs that can affect acetylcysteine, or that should not be used in the same nebulizer. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Warning

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Leventa - Levothyroxine Oral Solution, Leventa

Leventa (levothyroxine) Solution Rx

What is Leventa (levothyroxine) Solution for Dogs?

Leventa is a product containing the medication levothyroxine in an easy to use liquid formula for dogs. Levothyroxine is a medication used in animals with low thyroid hormones (hypothyroidism). Leventa provides a synthetic replacement for your dog’s thyroid hormones he/she can’t produce.

What risks are associated with Leventa?

Dogs with extremely high thyroid hormone levels (thyrotoxicosis), those who’ve had a heart attack, and those with Addison's Disease or any other adrenal insufficiency should not take Leventa. The safety of Leventa in pregnant dogs has not been evaluated, thus it’s use is cautioned. When Leventa is used at the correct dose for your dog, there should be no notable side effects because it mimics their natural hormones. However, at too high of doses Leventa can cause symptoms of too much thyroid hormone. These symptoms include, but aren’t limited to rapid heartbeat, weight loss, increased appetite, increased thirst, rapid breathing, and hyperactivity. If your dog experiences these side effects, it is important to call your pet's veterinarian immediately.

How to use Levothyroxine Solution for Dogs:

Shake the bottle thoroughly and remove the cap

Insert the syringe into the adapter on the top of the bottle of Leventa

Turn the bottle upside down and pull the plunger back until the black line on the plunger lines up with the dose your pet's veterinarian has prescribed

Turn the bottle back over (right side up) and remove the syringe from the bottle

Give the Leventa dose directly to your dog by mouth or you may also put it on their food

Give Leventa at the same time(s) every day to best improve your dog’s condition

Keep all follow up appointments with your pet's veterinarian to see how Leventa is working in your dog

Acquistare Baxicin (Noroxin) Senza Ricetta, Baxicin

Baxicin (Noroxin) Acquistare Online senza Ricetta

Baxicin (Noroxin) Spiegazione

Baxicin medicina e una categoria di farmaci noti come chinolonici antibiotici. Funzioni Baxicin per prevenire l'espansione associata a germi.

Baxicin non deve essere utilizzato per il comune raffreddore, l'influenza, alcune altre infezioni batteriche patogeni, dolori di gola o anche alcune altre piccole infezioni batteriche, o evitare le infezioni batteriche.

Baxicin puo essere indicato anche come Norfloxacin, Norfloxacine, Apo-Norflox, Norflohexal, Roxin, Utinor.

titolo generale associato con Baxicin Norfloxacin e in realta.

Marca associata con Baxicin Baxicin e in realta.

Baxicin (Noroxin) dosaggio

Baxicin e disponibile in:

400 mg dose regolare di materiale di attrito

Ottieni Baxicin per via orale con una tazza completa associata con l'acqua potabile.

Ottieni Baxicin generalmente due volte al giorno, almeno un'ora prima di almeno due ore dopo un sacrificio di uccelli |. Lasciando la | a |.> Utilizzando la cena o anche prodotti lattiero-caseari (e gary il ragazzo gadget. latticini, yogurt).

Ottieni Baxicin due ore prima o anche due ore a destra dopo l'uso di qualsiasi tipo di elementi che contiene magnesio, alluminio leggero o addirittura minerale di calcio.

Il dosaggio effettivo associato con le pillole dipende dalle condizioni cosi come la sua terapia consigliata.

Se volete ottenere migliori risultati di solito non smettere di usare Baxicin tutto ad un tratto.

Baxicin (Noroxin) manca associato a dosaggio

Di solito non si ottiene doppia dose. Nel caso in cui si salta il dosaggio e necessario portare una volta di tenere a mente per quanto riguarda al tuo carente. Quando e il momento per il dosaggio e necessario per portare avanti la propria normale routine di dosaggio.

Baxicin (Noroxin) Overdose

In caso di overdose Baxicin e anche di evitare grandi e necessario controllare il vostro medico o anche il medico immediatamente.

Baxicin (Noroxin) spazio di archiviazione

Shop a temperature spaziali tra i 10 ei 30 livelli D (59 e ottantasei livelli F) di umidita e la temperatura. Mantenere il contenitore chiuso saldamente. Rafforzare qualsiasi tipo di farmaco intatto successivo al giorno di scadenza. Mantenere da raggiungere di bambini.

Baxicin (Noroxin) Effetti negativi

Baxicin offre gli effetti negativi. Il piu tipico tendono ad essere:

Materiale sequestri di attrito

modificazioni psicologiche (tra cui le idee non comuni associati con il suicidio) materiale di attrito

prolungato dolorante tonsille attrito Materiale

materiale di attrito temperatura materiale

modifiche alla vista di attrito

la perdita dell'udito materiale di attrito

miglioramenti apportati sulla quantita o anche guardare associato con materiale di attrito pipi

ingiallimento dall'occhio o anche i pori e materiale d'attrito della pelle

Materiale svenimento di attrito

battere veloce, lento, o addirittura cardiaco anormale materiale d'attrito

semplice sanguinamento o materiale di attrito ecchimosi

formicolio, Tingley associato con le mani o addirittura anca e le gambe materiale di attrito

diarrea prolungata materiale di attrito

stomaco o addirittura disagio pancia o addirittura crampi dolori materiale di attrito

sangue o anche il muco all'interno del vostro materiale di feci di attrito

molto meno tipico e gravi effetti negativi in ??tutto con Baxicin: reazioni allergiche (orticaria, reazione inspirare ed espirare problemi, allergie, cosi come eruzione).

indicazioni di effetti negativi sono si basano su farmaci si potrebbero utilizzare ma in piu si basano su proprie condizioni di benessere e altri aspetti.

Baxicin (Noroxin) Controindicazioni

Di solito non si ottiene Baxicin nel caso in cui siete sensibili al fine di elementi Baxicin o chinolonici antibiotici, ad esempio ciprofloxacina, gatifloxacina, gemifloxacina, levofloxacina, lomefloxacina, moxifloxacina o anche ofloxacina.

Baxicin non deve essere utilizzato per il comune raffreddore, l'influenza, alcune altre infezioni batteriche patogeni, dolori di gola o anche alcune altre piccole infezioni batteriche, o evitare le infezioni batteriche.

Fare attenzione nel caso in cui ci si aspetta, andando a rimanere incinta, e / o l'allattamento al seno.

Siate cauti nel caso in cui si utilizza qualsiasi tipo di medico le ha prescritto o farmaco anche senza ricetta medica, la preparazione naturale, o addirittura supplemento.

Fare attenzione per coloro che hanno crisi epilettiche, problemi di mente (e. Gary il ragazzo gadget. Desapasionado arteriosclerosi, tumori, il miglioramento della pressione intracranica), malattia di massa muscolare / debolezza (e. Gary il ragazzo gadget. miastenia gravis), problemi di cuore (e. Gary il ragazzo gadget. cardiomiopatia, frequenza cardiaca piu lenta, punta torsione een, QTc periodo di proroga), malattia renale, discrepanza dei nutrienti (e. Gary il ragazzo gadget. potassio basso o anche di magnesio), passato storico associato a problemi di tendinite / tendine.

Ogni volta che si ottiene Baxicin e necessario utilizzare grandi quantita di liquidi.

Evitare le bevande alcoliche e le bevande che contiene il caffe (caffe, te verde, cole), di solito non consumare una considerevole quantita associata con cioccolatini.

Evitare pubblicita luce del sole continua, prendere il sole cabine o anche lampade solari. Fare uso di una protezione solare e indossare abiti che proteggono ogni volta che al di fuori.

Puo essere dannoso per prevenire Baxicin con tutto ad un tratto.

Baxicin (Noroxin) Domande generali

Queen: Che cosa e esattamente Baxicin?

Il: Baxicin medicina e una categoria di farmaci noti come chinoloni anti-biotics. A

Queen: Che cosa esattamente e Baxicin utilizzato per?

Il: Baxicin viene utilizzato per affrontare una serie di transmissions. A

Queen: Cosi come fa esattamente la funzione Baxicin?

I: funzioni Baxicin per prevenire l'espansione associata con germs. A

Queen: Molto miglior titolo generale relativa ai Baxicin?

Il: titolo generale e in realta Norfloxacin. A

Queen: Esattamente quello che devo FAG situazione associata a dosaggio manca?

Nel caso di dosaggio priva e necessario per pillola piu rapidamente possibile. Di solito non si ottiene doppia dose. E quando e davvero il momento piu felice per dose e necessario per portare avanti la propria normale routine associata con Baxicin using. A

Queen: non dobbiamo davvero sfruttare Baxicin?

Il: Di solito non utilizzare Baxicin per coloro che hanno reazioni allergiche in esso o anche la elements. A

Queen: May Baxicin grilletto attacco allergico?

Il: infatti, puo. Essere prudenti. Associata a sintomi di allergia al fine di Baxicin: allergie, prurito, infiammazione, grave affaticamento, problemi di inalazione e exhaling. A

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Omexel Generic, Omexel

Omexel

Omexel - Omexel is in a group of drugs called alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. Omexel relaxes the muscles in the prostate and bladder neck, making it easier to urinate.

Omexel is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate).

Omexel may also be used for other purposes not listed in this medication guide.

Omexel, a sulfamoylphenethylamine-derivative alpha-adrenoceptor blocker with enhanced specificity for the alpha-adrenoceptors of the prostate, is commonly used to treat benign prostatic hyperplasia (BPH). The drug is commercially available in a racemic mixture of 2 isomers, and is pharmacologically related to doxazocin, prazosin, and terazosin. However, unlike these drugs, Omexel has a higher affinity for the alpha-1A - adrenergic receptors, which are located in vascular smooth muscle. Studies show that Omexel has about 12 times greater affinity for alpha-1 adrenergic receptors in the prostate than those in the aorta, which may result in a reduced incidence of adverse cardiovascular effects.

Omexel is used to treat symptoms of an enlarged prostate gland in men. This enlargement of the prostate gland is called Benign Prostate Hypertrophy (BPH). The enlarged prostate gland may cause problems when you pass urine. Omexel relaxes the muscles in the prostate gland and bladder. This helps to improve symptoms such as difficulty in passing urine, slow or interrupted flow of urine, frequent urination and dribbling after passing urine.

Oral Benign prostatic hyperplasia

Adult: As HCl: As modified-release preparation: 400 mcg once daily. May increase to 800 mcg once daily after 2-4 wk if necessary. If therapy is interrupted for several days, restart with 400 mcg once daily. Dose to be taken 30 minutes after the same meal each day. CrCl (ml/min) Dosage Recommendation ≥10 No dose adjustment needed. <10 Not studied. Hepatic impairment: Moderate hepatic impairment (Child-Pugh classification A and B): No dose adjustment needed. Severe hepatic impairment: Avoid.

Indications: Benign prostatic hyperplasia.

Omexel is used by men to treat the symptoms of an enlarged prostate ( benign prostatic hyperplasia - BPH ). It does not shrink the prostate, but it works by relaxing the muscles in the prostate and the bladder. This helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate often or urgently (including during the middle of the night).

Omexel belongs to a class of drugs known as alpha blockers.

Do not use this medication to treat high blood pressure.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

Omexel may also be used to help your body "pass," or get rid of, kidney stones through urination. It has also been used to help treat bladder problems in women.

Omexel is used to treat men who have symptoms of an enlarged prostate gland, which is also known as benign enlargement of the prostate (benign prostatic hyperplasia or BPH). Benign enlargement of the prostate is a problem that can occur in men as they get older. The prostate gland is located below the bladder. As the prostate gland enlarges, certain muscles in the gland may become tight and get in the way of the tube that drains urine from the bladder. This can cause problems in urinating, such as a need to urinate often, a weak stream when urinating, or a feeling of not being able to empty the bladder completely.

Omexel helps relax the muscles in the prostate and the opening of the bladder. This may help increase the flow of urine or decrease the symptoms. However, Omexel will not shrink the prostate. The prostate may continue to get larger. This may cause the symptoms to become worse over time. Therefore, even though Omexel may lessen the problems caused by enlarged prostate now, surgery still may be needed in the future.

Omexel is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Omexel is used in certain patients with the following medical conditions:

Ureteric stone (a kidney stone that has moved down into the ureter).

Preflam Rezeptfrei Kaufen ? Qualitat; ? Mit Niedrigen Preisen; ? Lieferung, Preflam

Prednisolon zur Behandlung von Allergien, Arthritis, Probleme mit der Atmung (zB Asthma), bestimmte Blutkrankheiten, Kollagenosen (zB Lupus), bestimmte Erkrankungen des Auges (z. B. Keratitis), Krebs (z. B. Leukamie), endokrinen Problemen (zB verwendet werden, Nebennierenrindeninsuffizienz), Darm-Problemen (zB Colitis ulcerosa), Schwellung aufgrund bestimmter Bedingungen oder Hautkrankheiten (zB Psoriasis). Prednisolon ist ein Kortikosteroid. Es funktioniert, indem Sie das Immunsystem des Korpers als Reaktion auf verschiedene Bedingungen und abnehmender Entzundung.

Verwenden Sie Prednisolon wie von Ihrem Arzt verordnet wurde.

Nehmen Sie Prednisolon durch den Mund mit Lebensmitteln.

Wenn Sie eine Dosis von Prednisolon, bringen Sie es so bald wie moglich. Wenn es fast Zeit fur Ihre nachste Dosis ist, uberspringen Sie die vergessene Dosis und gehen Sie zuruck zu Ihrem regelma?igen Dosierungsschema. Nehmen Sie nicht 2 Dosen auf einmal.

Fragen Sie Ihren Arzt Fragen konnen Sie sich uber die Verwendung von Prednisolon haben kann.

Shop Prednisolon bei Raumtemperatur zwischen 68 und 77 Grad F (20 und 25 Grad C) in einem dicht geschlossenen Behalter. Lager weg von der Hitze, Feuchtigkeit und Licht. Nicht im Bad. Halten Prednisolone au?erhalb der Reichweite von Kindern und weg von Haustieren.

Verwenden Sie KEINE Prednisolon, wenn:

Sie sind allergisch gegen jegliche Zutaten in Prednisolone

Sie haben eine systemische Pilzinfektion, eine bestimmte Art von Malaria, Entzundungen des Sehnervs oder Herpes-Infektion des Auges

Sie soll eine Live-oder abgeschwachten lebenden Impfung (z. B. Pocken)

Sie sind unter Mifepriston.

Fragen Sie Ihren Arzt sofort, wenn einer dieser Punkte auf Sie zutreffen.

Einige medizinische Bedingungen konnen mit Prednisolon interagieren. Informieren Sie Ihren Arzt oder Apotheker, wenn Sie irgendwelche medizinischen Bedingungen haben, vor allem, wenn einer der folgenden Punkte auf Sie zutrifft:

wenn Sie schwanger sind, planen, schwanger zu werden, oder stillen

wenn Sie verschreibungspflichtige oder nicht verschreibungspflichtige Arzneimittel, pflanzliche Zubereitung oder Nahrungserganzungsmittel

wenn Sie Allergien gegen Medikamente, Nahrungsmittel oder andere Substanzen,

wenn Sie eine Geschichte von Herzproblemen (zB Herzinsuffizienz), Herzinfarkt, Bluthochdruck, Nieren-, Leber-Probleme, Diabetes, Krampfanfalle, eine Unterfunktion der Schilddruse, Nebenniere Probleme Flussigkeitsansammlungen (zB Schwellung der Hande. Knochel oder Fu?), oder irgendwelche geistigen oder Stimmungsschwankungen

wenn Sie haben oder vor kurzem einen Pilz-, Bakterien, Viren oder andere Art von Infektion, Herpes-Infektion des Auges; Windpocken; Masern oder Gurtelrose

wenn Sie HIV-Infektion oder Tuberkulose (TB)-Infektion, oder wenn Sie jemals einen positiven TB-Hauttest

wenn Sie irgendwelche Magenprobleme (zB Geschwure), Darm-Problemen (zB Verstopfung, Perforation oder Infektion, unerklarliche Durchfall, Divertikulitis, Colitis ulcerosa), die jungsten Darm-Operation oder eine Entzundung der Speiserohre

wenn Sie schwache Knochen (zB Osteoporose) oder Muskel-Probleme (zB Myasthenia gravis)

wenn Sie vor kurzem eine Impfung (z. B. Pocken).

Einige Arzneimittel konnen mit Prednisolon interagieren. Informieren Sie Ihren Arzt, wenn Sie andere Arzneimittel einnehmen, vor allem einer der folgenden Eigenschaften sind:

Clarithromycin, Cyclosporin, Ostrogene (zB Estradiol), orale Kontrazeptiva (zB Antibabypille) oder Ketoconazol, weil sie das Risiko erhohen, Prednisolone die Nebenwirkungen

Barbiturate (zB Phenobarbital), Carbamazepin, Ephedrin, Hydantoinen (zB Phenytoin) oder Rifampicin, weil sie Prednisolone die Effektivitat verringern

Cholinesterasehemmer (zB Pyridostigmin), Aspirin, Diuretika (z. B. Hydrochlorothiazid, Furosemid), Methotrexat, Mifepriston, Chinolon-Antibiotika (zB Ciprofloxacin), Ritodrin, oder Live-oder abgeschwachte Lebendimpfstoffe, weil das Risiko der Nebenwirkungen konnen durch Prednisolon erhoht werden

Antikoagulantien (zB Warfarin), Hydantoinen (zB Phenytoin) oder getotet oder Impfstoffe inaktiviert, weil ihre Wirksamkeit von Prednisolon verringert werden kann.

Dies kann nicht eine vollstandige Liste aller Interaktionen, die auftreten konnen. Fragen Sie Ihren Arzt, wenn Prednisolone mit anderen Medikamenten, die Sie einnehmen. Prufen Sie mit Ihrem Arzt, bevor Sie starten, stoppen, oder andern Sie die Dosis einer Medizin.

Wichtige Sicherheitshinweise:

Vermeiden Sie Alkohol, wahrend Sie Prednisolon werden.

Prednisolon kann niedriger die Fahigkeit Ihres Korpers, Infektionen zu bekampfen. Vermeiden Sie den Kontakt mit Menschen, die Erkaltungen oder Infektionen. Informieren Sie Ihren Arzt, wenn Sie Anzeichen einer Infektion wie Fieber, Halsschmerzen, Hautausschlag, oder Schuttelfrost.

Wenn Sie noch nicht hatte Windpocken, Gurtelrose oder Masern, vermeiden Sie Kontakt mit jemandem, der tut.

Wenn Sie die Einnahme Prednisolone werden regelma?ig uber einen langeren Zeitraum, tragen eine ID-Karte zu allen Zeiten, die Sie treffen Prednisolone sagt.

Erhalten keine Lebendimpfstoff (zB Masern, Mumps, Pocken) wahrend der Einnahme von Prednisolon sind. Sprechen Sie mit Ihrem Arzt, bevor Sie irgendwelche Impfstoff erhalten.

Informieren Sie Ihren Arzt oder Zahnarzt, dass Sie Prednisolon, bevor Sie eine arztliche oder zahnarztliche Versorgung, Notfallversorgung, oder eine Operation zu erhalten.

Diabetes-Patienten - Prednisolon beeintrachtigen konnen Sie Ihren Blutzucker. Check Blutzucker eng. Fragen Sie Ihren Arzt, bevor Sie die Dosis Ihres Diabetes Medizin zu andern.

Lab-Tests, einschlie?lich die Funktion der Nebennierenrinde Tests konnen durchgefuhrt werden, wahrend Sie Prednisolon verwenden. Diese Tests konnen verwendet werden, um Ihren Zustand zu uberprufen oder auf Nebenwirkungen zu uberwachen. Achten Sie darauf, alle Arzt-und Labor-Terminen.

Vorsicht ist geboten bei der Verwendung Prednisolon bei Kindern, sie moglicherweise empfindlicher auf deren Auswirkungen.

Kortikosteroide konnen Wachstumsrate bei Kindern und Jugendlichen in einigen Fallen beeinflussen. Sie konnen regelma?ige Kontrollen Wachstum brauchen, wahrend sie Prednisolon nehmen.

Schwangerschaft und Stillzeit: Wenn Sie schwanger werden, wenden Sie sich an Ihren Arzt. Sie mussen die Vorteile und Risiken der Verwendung von Prednisolon zu diskutieren, wahrend Sie schwanger sind. Prednisolon ist in der Muttermilch gefunden. Wenn Sie sind oder werden stillen, wahrend Sie Prednisolon verwenden sind, mit Ihrem Arzt uberprufen. Diskutieren Sie mogliche Risiken fur Ihr Baby.

Wenn Sie auf langfristige oder hochdosierte Therapie und sind Sie plotzlich aufhoren Prednisolon, mussen Sie eventuell Entzugserscheinungen wie Fieber, Erbrechen, Appetitlosigkeit, Durchfall, Ubelkeit, Schwindel, Gewichtsverlust, Schwache, allgemeine korperliche Beschwerden, Gelenk-oder Muskelschmerzen Schmerzen.

Alle Arzneimittel konnen Nebenwirkungen haben, die aber viele Menschen haben keine oder nur geringfugige, Nebenwirkungen.

Erkundigen Sie sich bei Ihrem Arzt, wenn dieser am haufigsten auftretenden Nebenwirkungen fortbestehen oder storend empfunden werden:

Akne; Ungeschicklichkeit, Schwindel, Gesichtsrotung, Gefuhl einer wirbelnde Bewegung, allgemeine korperliche Beschwerden, Kopfschmerzen, gesteigerter Appetit, vermehrtes Schwitzen, Ubelkeit, Nervositat, Schlaflosigkeit, Magenbeschwerden.

Arztlich behandeln lassen, sofort, wenn dieser schwere Nebenwirkungen auftreten:

Schwere allergische Reaktionen (Hautausschlag, Nesselsucht, Juckreiz, Atembeschwerden, Engegefuhl in der Brust, Schwellungen im Mund-, Gesichts-, Lippen oder Zunge), schwarz, Teerstuhle, Veranderungen des Korperfetts, Anderungen in der Menstruation, Veranderungen der Hautfarbe. Brustschmerzen, leichte Blutergusse oder Blutungen, erhohte Hunger, Durst oder Harndrang, psychische oder Stimmungsschwankungen (zB Depression), Muskelschmerzen, Schwache oder verschwenden, Krampfanfalle, schwere Ubelkeit oder Erbrechen, Kurzatmigkeit, Anzeichen einer Infektion ( zB Fieber, Schuttelfrost, anhaltende Halsschmerzen), plotzliche schwere Schwindel oder Kopfschmerzen, Schwellungen der Knochel, Fu?e oder Hande, Sehnen-oder Knochenschmerzen; Ausdunnung der Haut, ungewohnliche Hautgefuhl, ungewohnliche Gewichtszunahme, Sehstorungen oder andere Augenprobleme; erbrechen, das aussieht wie Kaffeesatz.

Dies ist keine vollstandige Liste aller Nebenwirkungen, die auftreten konnen. Wenn Sie Fragen zu Nebenwirkungen haben, wenden Sie sich an Ihren Arzt.

Dolak Name Meaning - Dolak Family History At, Dolak

Dolak Family History

Dolak Name Meaning Czech and Slovak (Dolák): topographic name for someone living in the lower part of a village, a variant of Dolejs (see Doles 2), or habitational name for someone from a place called Dul or Dolan. Polish: patronymic form of Dola meaning ‘fate’, ‘destiny’. Polish: topographic name from a derivative of dó ‘pit’, ‘hole’. Polish: possibly from a pet form of the personal name Adolf.

Source: Dictionary of American Family Names ©2013, Oxford University Press

8,433 Historical Documents with Dolak on Ancestry 5,043 Birth, Marriage, and Deaths 1,257 Census and Voter Lists 304 Military Records 462 Immigration Records 1,367 Member Trees

Ready to discover your family story?

Simply start with yourself and we'll do the searching for you.

Atorvastatin - Brand Name List From, Sortis

Atorvastatin

See also.

Disclaimer: The indications, uses and warnings for individual medications outside the USA are determined by local regulatory bodies in each country or region. The Drugs. com website is intended primarily for audiences in the United States and its territories. Indications, uses and warnings on Drugs. com patient information leaflets are derived from FDA product labels and may differ in countries outside the USA. Every effort has been made to ensure that the information provided on this page is accurate, up-to-date and complete, but no guarantee is made to that effect. Drugs. com does not endorse drugs, diagnose patients or recommend specific therapies. The information on this page is not a substitute for the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that a drug or drug combination is safe, effective or appropriate for any given patient. Drugs. com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Always consult your doctor or healthcare specialist for medical advice.

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Bestsellers Buy Propecia At, Tricofarma

Bestsellers

Propecia (Tricofarma)

Propecia is used for treating certain types of male pattern hair loss (androgenic alopecia) in men. Propecia is a steroid reductase inhibitor. It works by reducing the amount of the hormone dihydrotestosterone (DHT) in the body. This may block certain types of hair loss in men.

Use Propecia as directed by your doctor.

Take Propecia by mouth with or without food.

Continue to take Propecia even if you notice improvement of your symptoms. Do not miss any dose.

Taking Propecia at the same time each day will help your remember to take it.

If you miss a dose of Propecia, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Propecia.

Store Propecia at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Propecia out of the reach of children and away from pets.

Active Ingredient: Finasteride.

Inactive Ingredients: lactose monohydrate, microcrystalline cellulose, pregelatinized starch, sodium starch glycolate, hydroxypropyl methylcellulose, hydroxypropyl cellulose LF, titanium dioxide, magnesium stearate, talc, docusate sodium, yellow ferric oxide, and red ferric oxide.

Propecia can affect a blood test called PSA (Prostate-Specific Antigen) for the screening of prostate cancer. If you have a PSA test done, you should tell your doctor(s) that you are taking Propecia. Because Propecia decreases PSA levels, changes in PSA levels will need to be carefully evaluated by your doctor(s). Any increase in follow-up PSA levels from their lowest point should be carefully evaluated even if the test results are still within the normal range for men not taking Propecia. You should also tell your doctor if you have not been taking Propecia as prescribed because this may affect the PSA test results. For more information, talk to your doctor.

Do NOT use Propecia if:

you are allergic to any ingredient in Propecia

the patient is a woman or a child.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Propecia. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a narrowing or blockage in the urinary tract, prostate cancer, or trouble urinating

if you have a history of abnormal liver function tests or liver problems.

Some medicines may interact with Propecia. However, no specific interactions with Propecia are known at this time. Ask your health care provider if Propecia may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

You may need to take Propecia for up to 3 months before you notice any improvement. Do not take more than the recommended dose without checking with your doctor.

If your symptoms do not improve within 12 months, check with your doctor. You may need to discuss other treatment options.

Infrequently, Propecia may cause decreased sexual desire or ability. These effects usually decrease in men who continue to take Propecia. If they continue or become bothersome, check with your doctor.

Propecia may increase the risk of certain birth defects, including abnormal formation of genitalia in male fetuses. Propecia is coated to prevent contact with finasteride while handling undamaged tablets. The coating is not effective if the tablets are damaged, broken, or crushed. Women who are pregnant or may be pregnant should avoid contact with damaged, broken, or crushed tablets. If contact occurs, tell your doctor at once.

Propecia may interfere with certain lab tests, including prostate-specific antigen tests. Be sure your doctor and lab personnel know you are taking Propecia.

Propecia is for use by men only and should not be used by women or children.

All medicines may cause side effects, but many people have no, or minor, side effects.

No common side effects have been reported with Propecia.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast enlargement, lumps, pain, or tenderness; nipple discharge; testicular pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Your order will be packed safely and secure and dispatched within 24 hours. This is how your parcel will look like, the images are photographs of real shipments. It has the size of a normal protected envelope and it does not disclose its contents.

Also you may like:

Panalgesic (Paracetamol, Codeine Phosphate - Doxylamine Succinate) Drug, Panagesic

Panalgesic

NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia. This page contains answers to some common questions about Panalgesic. It does not contain all the information that is known about Panalgesic. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risk of you using this medicine against the benefits he/she expects it will have for you. If you have any concerns about using this medicine, ask your doctor or pharmacist. Bookmark or print this page, you may need to read it again.

What is Panalgesic used for

Panalgesic is used to relieve pain and tension. It is used for painful conditions including tension headache, nerve pain and period pain. Paracetamol and codeine work together to stop the pain messages from getting through to the brain. Doxylamine is an antihistamine with calmative effects.

Your doctor may have prescribed this medicine for another use. If you want more information, ask your doctor or pharmacist.

Codeine is addictive.

Before you take Panalgesic

When you must not use it

You should not take Panalgesic if you are allergic to paracetamol, codeine, doxylamine or any of the ingredients listed under "Product Description".

The symptoms of an allergic reaction may include a rash, itching, swelling of the face, lips or tongue, which may cause difficulty in swallowing or breathing, asthma attack or hayfever.

Do not take Panalgesic if you are a CYP 2D6 ultra-rapid metaboliser.

Do not take Panalgesic if you have glucose-6-phosphate-dehydrogenase deficiency.

Do not take Panalgesic if you have impaired lung, liver or kidney function.

Panalgesic should not be used in children (aged below 18 years) who undergo tonsillectomy and/or adenoidectomy.

Do not take Panalgesic during the third trimester of pregnancy.

Do not take Panalgesic during labour, especially if the baby is premature.

This medicine may produce withdrawal effects in the newborn baby.

Do not take Panalgesic if you are breastfeeding or planning to breastfeed.

Panalgesic passes into breast milk and there is a possibility your baby may be affected.

Do not use Panalgesic after the expiry date (EXP) printed on the pack.

If you take it after the expiry date it may have no effect at all, or worse, have an entirely unexpected effect.

Do not use Panalgesic if the packaging is torn or shows signs of tampering.

Do not use this medicine to treat any other complaint unless your doctor says it is safe. Do not give this medicine to anyone else.

Before you start to take it

You must tell your doctor if:

You have allergies to any ingredients listed under "Product Description" at the end of this leaflet.

You have allergies to aspirin or any other NSAID medicine

You have any of these conditions:

Lung problems, such as asthma or respiratory depression

Impaired liver or kidney function

G6PD deficiency, a human enzyme deficiency

Are under 18 and have undergone adenoidectomy and/or tonsillectomy

If you know you are a CYP 2D6 ultra-rapid metaboliser

You drink large amounts of alcohol.

Tell your doctor if you are pregnant or intend to become pregnant.

Your pharmacist or doctor will discuss the risks and benefits of taking it if you are pregnant.

Taking other medicines

You should talk with your doctor or pharmacist if you are using any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food store.

Some medicines and Panalgesic may interfere with each other.

Any medicines causing sleepiness

Tranquillisers (medicines for anxiety or nerves)

Any medicines which thin the blood

Medicine to treat epilepsy

Metoclopramide, a medicine used to control nausea and vomiting

Propantheline, a drug used to treat stomach ulcers

Chloramphenicol, an antibiotic used to treat ear and eye infections

Flucloxacillin, zidovudine or rifampicin, drugs used to treat infections

These medicines may be affected by Panalgesic or may affect the way Panalgesic works.

Your doctor or pharmacist can tell you what to do if you are taking any of these medicines.

If you have not told your doctor about any of these things, tell him/her before you take Panalgesic.

How to take Panalgesic

How much to take

The label on your pack of Panalgesic will tell you how to take your medicine and how often. If you are unsure about the directions ask your doctor or pharmacist.

The usual dose is:

Adults and Children over 12 years: 2 capsules.

This dosage may be repeated in 4 hours if necessary.

You should not take more than 8 capsules in 24 hours.

If Panalgesic is not adequately controlling your pain, do not increase the dose. Please see your doctor.

Panalgesic is not recommended for children under 12 years.

How to take it

Swallow the capsules whole with a little water or other liquid.

The directions given to you by your doctor or pharmacist may be different from the information in this leaflet.

If you are unsure what dose to take ask your pharmacist or doctor.

If you forget to take it

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Do not take a double dose of Panalgesic to make up for the dose missed.

If you have trouble remembering when to take your medicine, ask your pharmacist for some hints.

If you take too much (Overdose)

Immediately telephone your doctor or Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency at your nearest hospital, if you think that you or anyone else has taken too much Panalgesic.

Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

Keep telephone numbers of these places handy.

If you take too many capsules you may feel nauseous, lightheaded, dizzy or drowsy. Fits can occur in children.

While you are taking Panalgesic

Things you must do

Take Panalgesic exactly as your doctor has prescribed.

Tell all your doctors, dentists and pharmacists that you are taking Panalgesic.

If you are about to be started on any new medicine, tell your doctor and pharmacist that you are taking Panalgesic.

Tell your doctor if you become pregnant while taking Panalgesic.

If you plan to have surgery that needs a general anaesthetic, tell your doctor or dentist that you are taking this medicine.

Things to be careful of

Panalgesic may cause dizziness or drowsiness in some people, especially after the first dose.

If affected do not drive a car, operate machinery or do anything else that could be dangerous if you are dizzy or drowsy. Children should not ride bicycles if affected and should be supervised to avoid potential harm.

Be careful if you are elderly, unwell or taking other medicines.

Some people may experience side effects such as drowsiness, confusion, dizziness and unsteadiness, which may increase the risk of a fall.

Do not drink alcohol.

Drinking alcohol increases the likelihood of becoming drowsy. It is not recommended that you drink alcohol while taking Panalgesic.

Panalgesic may be habit forming if taken in high doses for extended periods of time.

Please ask your doctor or pharmacist if you are concerned about this.

Side Effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while taking Panalgesic.

Like other medicines, Panalgesic can cause some side effects. If they occur, they are most likely minor and temporary. However, sometimes they are serious and need medical treatment.

Ask your doctor or pharmacist any questions you may have.

Tell your doctor if you notice any of the following and they worry you:

Stomach problems such as:

painful red areas with blisters and peeling layers of skin which may be accompanied by fever and/or chills

hepatitis (symptoms include loss of appetite, itching, yellowing of the skin and eyes, light coloured bowel motions, dark coloured urine)

If any of the following happen, stop taking this medicine and tell your doctor immediately, or go to Accident and Emergency at your nearest hospital:

swelling of the face, lips, mouth or throat, which may cause difficultly in swallowing or breathing

severe blisters and bleeding in the lips, eyes, mouth, nose and genitals

yellowing of the skin and eyes (jaundice)

These are very serious side effects. If you have them, you may have had a serious allergic reaction to Panalgesic. You may need urgent medical attention or hospitalisation.

These side effects are very rare.

If you believe Panalgesic is not working well for you do not increase the dose. Please see your doctor.

Some people may get other side effects not listed above.

Tell your doctor if you notice anything else that is making you feel unwell.

After taking Panalgesic

Storage

Keep your capsules in the blister pack until it is time to take them.

If you take the capsules out of the box or the blister pack they will not keep well.

Keep Panalgesic in a cool, dry place where the temperature stays below 30°C.

Heat and dampness can destroy some medicines. Do not leave Panalgesic in the car on hot days.

Do not store Panalgesic or any other medicine in the bathroom or near a sink.

Keep Panalgesic where young children cannot reach it.

A locked cupboard at least one and a half metres above the ground is a good place to store medicines.

Disposal

If your doctor tells you to stop taking the capsules, ask your pharmacist what to do with any capsules that are left over.

This is not all the information that is available on Panalgesic. If you have any more questions or are not sure about anything, ask your doctor or pharmacist.

Panalgesic comes as a yellow and white capsule marked 'PANALGESIC' in black ink on the body and cap of the capsule.

A box contains 24 capsules.

Product description

Doxymono, Doxymono

Product Description Common use Doxycyline is a synthetic broad-spectrum antibiotic derived from tetracycline and used to treat many different bacterial infections, such as infections of urinary tract, acne, gonorrhea, chlamydiosis, periodontitis (gum disease), blemishes, bumps, and acne-like lesions caused by rosacea.

Dosage and directions This medication should be taken after a meal with a big glass of water to decrease irritation of esophagus. Daily dose should be taken as a single dose or divided in two (12 hours between each one). Do not take it in larger amounts or continue to take it after the administered period. Certain brands of this medication cannot be used with dairy products. Do not crush, break, or open a delayed-release capsule, eat the pill whole. If it is an oral suspension shake it before use and measure with special measuring spoon. Never take this drug if it is expired as it may damage your kidney.

Precautions Usage of Doxycycline during growth of teeth may result in their permanent color change. Avoid exposure of your body to prolonged UV radiation during treatment and 4-5 days after it. If long treatment with this medication is prescribed a regular monitoring of peripheral blood cell content, liver function tests and determination of nitrogen and urea in serum are required.

Contraindications Hypersensitivity to Doxycycline and tetracyclines, pregnancy (second half of the term), breastfeeding, infancy (for children younger than 9 y. o.), leucopenia, porphyria, severe liver failure.

Possible side effect Side effects caused by Doxycycline may appear as headache, dizziness, blurred vision, fever, chills, body aches, red skin rash, pale or yellowed skin, dark colored urine, severe pain in upper stomach, loss of appetite, jaundice, easy bruising or bleeding. Contact your doctor if you experience severe effects listed above.

Drug interaction Co-administration with aluminum, magnesium, or calcium based antacids is not recommended as Doxycyline absorption maybe slowered. Minerals (such as calcium or iron) or with bismuth subsalicylate have the same effect. Doxycycline is reported to enhance the activity of warfarin. Phenytoin (Dilantin), carbamazepine (Tegretol), and barbiturates (such as phenobarbital) may enhance the metabolism of Doxycycline.

Missed dose Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose In case of serious and persistent nausea, vomiting, and diarrhea consult your doctor.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Dexamethasone Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Dexamethazon

dexamethasone

GENERIC NAME(S): DEXAMETHASONE

Uses

Dexamethasone is used to treat conditions such as arthritis. blood /hormone/immune system disorders. allergic reactions, certain skin and eye conditions, breathing problems. certain bowel disorders, and certain cancers. It is also used as a test for an adrenal gland disorder (Cushing's syndrome ).

This medication is a corticosteroid hormone (glucocorticoid). It decreases your body's natural defensive response and reduces symptoms such as swelling and allergic-type reactions.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

How to use dexamethasone

Take this medication by mouth as directed by your doctor. Take with food or milk to prevent stomach upset. Take this medication by mouth with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. If you are using the liquid form of the medication, use a medication-measuring device to carefully measure the prescribed dose. Do not use a household spoon.

If you take this medication once daily, take it in the morning before 9 AM. If you are taking this medication every other day or on another schedule besides a daily one, it may help to mark your calendar with a reminder.

The dosage and length of treatment are based on your medical condition and response to therapy. Your doctor may attempt to reduce your dose slowly from time to time to minimize side effects.

Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Follow the dosing schedule carefully, and take this medication exactly as prescribed.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

Inform your doctor if your condition does not improve or worsens.

Side Effects

Stomach upset, headache. dizziness. menstrual changes, trouble sleeping. increased appetite, or weight gain may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: signs of infection (e. g. fever, persistent sore throat ), bone/joint pain. increased thirst/urination, fast/slow/irregular heartbeat. eye pain /pressure, vision problems, heartburn. black stools, vomit that looks like coffee grounds, puffy face, swelling of the ankles /feet, stomach/abdominal pain. pain/redness/swelling of arms/legs, tiredness, mental/mood changes (e. g. depression. mood swings, agitation), unusual hair /skin growth, muscle pain /cramps. weakness. easy bruising/bleeding, slow wound healing, thinning skin, seizures .

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking dexamethasone, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids (e. g. prednisone ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: active fungal infections.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other infections (e. g. tuberculosis. herpes), kidney disease. liver disease, mental/mood conditions (e. g. psychosis, anxiety, depression), low blood minerals (e. g. low potassium /calcium), thyroid disease, stomach/intestinal problems (e. g. ulcer, ulcerative colitis. diverticulitis. unexplained diarrhea), high blood pressure. heart problems (e. g. congestive heart failure. recent heart attack), diabetes, eye diseases (e. g. cataracts, glaucoma, herpes infection of the eye), brittle bones (osteoporosis), history of blood clots.

This medication may mask signs of infection or put you at greater risk of developing very serious infections. Report any injuries or signs of infection (e. g. persistent sore throat/fever/cough, pain during urination, muscle aches) that occur during treatment.

Using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past 12 months. Tell your doctor right away if you develop unusual/extreme tiredness or weight loss. If you will be using this medication for a long time, carry a warning card or medical ID bracelet that identifies your use of this medication.

Do not have immunizations, vaccinations, or skin tests unless specifically directed by your doctor. Live vaccines may cause serious complications (e. g. infection) if given while you are taking this medication. Avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.

Avoid contact with people who have chickenpox or measles unless you have previously had these diseases (e. g. in childhood). If you are exposed to one of these infections and you have not previously had it, seek immediate medical attention.

If you have a history of ulcers or take large doses of aspirin or other arthritis medication, limit alcoholic beverages while taking this medication to decrease the risk of stomach/intestinal bleeding. Consult your doctor or pharmacist for more details.

If you have diabetes, this drug may make it harder to control your blood sugar levels. Monitor your blood sugar levels regularly and inform your doctor of the results. Your medicine, exercise plan, or diet may need to be adjusted.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

This medication may slow down a child's growth if used for a long time. Consult the doctor or pharmacist for more details. See the doctor regularly so your child's height and growth can be checked.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for an extended time and/or at high doses may have low levels of corticosteroid hormone. Tell your doctor right away if you notice symptoms such as persistent nausea/vomiting, severe diarrhea, or weakness in your newborn.

This drug may pass into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breast - feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aminoglutethimide, birth control pills, certain cancer drugs (dasatinib, lapatinib, sunitinib, aldesleukin), caspofungin, cholestyramine, cobicistat, cyclosporine, digoxin, elvitegravir, drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel "blood thinners" such as dabigatran/warfarin, NSAIDs such as aspirin/celecoxib/ibuprofen), ephedrine, estrogen hormone replacement, HIV protease inhibitors (such as indinavir), isoniazid, mifepristone, rilpivirine, thalidomide.

Other medications can affect the removal of dexamethasone from your body, which may affect how dexamethasone works. Examples include azole antifungals (such as ketoconazole), barbiturates (such as phenobarbital), rifamycins (such as rifampin), certain medications used to treat seizures (such as phenytoin, carbamazepine), among others.

If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

This medication may interfere with certain laboratory tests (including skin tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

If this medication is used for an extended time, laboratory and/or medical tests (e. g. blood sugar/mineral levels, blood pressure, eye exams) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Talk with your doctor about making changes to your lifestyle that may decrease the side effects of this medication (e. g. weight-bearing exercise, dietary changes including controlling salt intake and getting more potassium/calcium).

Missed Dose

If you are taking this medication daily and on a regular schedule, and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

If you are taking this medication every other day or are slowly reducing your dose, and you miss a dose, then contact your doctor or pharmacist right away to establish a new dosing schedule.

Storage

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised December 2015. Copyright(c) 2015 First Databank, Inc.

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Anti Fungal Buy Mycelex-G At, Fungikad

Mycelex-G (Clotrimazole) is an antifungal medication. It prevents fungus from growing.

Clotrimazole vaginal is used to treat vaginal candida (yeast) infections.

Clotrimazole vaginal may also be used for purposes other than those listed in this medication guide.

Use Mycelex-G exactly as directed by your doctor, or follow the directions that accompany the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using this medication.

Insert the tablet, suppository, or cream into the vagina using the applicator as directed.

Use this medication continuously for the prescribed amount of time, even during your menstrual period.

You can use a sanitary napkin to prevent the medication from staining your clothing but do not use a tampon.

If the infection does not clear up after you have finished one course of therapy, or if it appears to get worse, see your doctor. You may have another type of infection.

Avoid getting this medication in your eyes, nose, or mouth. Store clotrimazole vaginal at room temperature away from moisture and heat.

Active ingredient: Clotrimazole

Clotrimazole is an antifungal medication. It prevents fungus from growing.

Clotrimazole vaginal is used to treat vaginal candida (yeast) infections.

It also may be used for purposes other than those listed in this medication guide.

Safety information

Do not use clotrimazole vaginal if you have ever had an allergic reaction to it.

If this is the first time that you have ever had symptoms of a vaginal yeast infection, consult your doctor before using this medication.

Do not use clotrimazole vaginal if you have a fever, abdominal pain, foul-smelling discharge, diabetes, HIV, or AIDS. Consult your doctor. Do not use this medication without first talking to your doctor if you are pregnant. Do not use clotrimazole vaginal without first talking to your doctor if you are breast-feeding a baby. Do not use this medication if you are younger than 12 years of age.

Important safety information

Use this medication for the full amount of time prescribed by your doctor or recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.

Avoid wearing tight-fitting, synthetic clothing (e. g. panty hose) that does not allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed. Avoid getting this medication in your eyes, nose, or mouth.

Side effects

Stop using clotrimazole vaginal and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

Other, less serious side effects may be more likely to occur. These include burning, itching, irritation of the skin, and an increased need to urinate.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Avoid using other vaginal creams or douches at the same time as clotrimazole unless your doctor approves.

Drugs other than those listed here may also interact with clotrimazole vaginal. Talk to your doctor and pharmacist before taking any prescription or over the counter medicines.

Packaging

Your order will be packed safely and secure and dispatched within 24 hours. This is how your parcel will look like, the images are photographs of real shipments. It has the size of a normal protected envelope and it does not disclose its contents.

Special offers

Femodene Tablets, Femodeen

FEMODENE TABLETS

Transcript

Package leaflet: Information for the user

Femodene® Gestodene, Ethinylestradiol Important things to know about combined hormonal contraceptives (CHCs): R They are one of the most reliable reversible methods of contraception if used correctly. R They slightly increase the risk of having a blood clot in the veins and arteries, especially in the first year or when restarting a combined hormonal contraceptive following a break of 4 or more weeks. R Please be alert and see your doctor if you think you may have symptoms of a blood clot (see section 2.3 ‘Blood clots’). R The Pill may reduce your risk of cancer of the ovary and womb if used in the long term. R The Pill will not protect you against sexually transmitted diseases. R This medicine can increase your risk of problems such as blood clots and breast cancer. R Some women should not take the Pill because of current medical problems or illnesses. Please read this leaflet to make sure Femodene is right for you. R To prevent pregnancy it is important to take Femodene as instructed and start each pack on time. Please make sure that you understand what to do if you miss a pill or if you think you are pregnant. Read all of this leaflet carefully before you start taking this medicine. R Keep this leaflet. You may need to read it again. R If you have any questions or need more advice, ask your doctor, family planning nurse or pharmacist. R This medicine has been prescribed for you. Do not pass it on to others. It may harm them. R If any of the side effects gets severe, or if you notice any not listed in this leaflet, please tell your doctor, family planning nurse or pharmacist. In this leaflet 1. What Femodene does 2. What you need to know before you use Femodene

2.1 When you should not use Femodene 2.2 When to take special care with Femodene 2.3 Blood clots 2.4 The Pill and cancer 2.5 Taking other medicines 2.6 Taking Femodene with food and drink 2.7 Pregnancy and breast-feeding 2.8 Driving and using machines 2.9 Femodene contains lactose and sucrose 3. Taking Femodene

3.1 How to take it 3.2 Starting Femodene 3.3 A missed pill 3.4 A lost pill 3.5 If you are sick or have diarrhoea 3.6 Missed a period – could you be pregnant? 3.7 Taking more than one pill should not cause harm 3.8 When you want to get pregnant 4. Possible side effects 4.1 Serious side effects – see a doctor straight away 4.2 Less serious side effects 4.3 Bleeding between periods should not last long 1.3.2.2 5. How to store Femodene 6. What is in Femodene and who makes it

1. What Femodene does Femodene is a combined oral contraceptive pill (‘the Pill’). You take it to stop you getting pregnant. This contraceptive contains two types of female sex hormones, oestrogen and progestogen. These hormones stop you getting pregnant by working in three ways: by preventing an egg being released from your ovaries; by making the fluid (mucus) in your cervix thicker, which makes it more difficult for sperm to enter the womb; and by preventing the lining of your womb thickening enough for an egg to grow in it. Femodene is a 21-day Pill – you take one each day for 21 days, followed by 7 days when you take no pills. The benefits of taking the Pill include: R it is one of the most reliable reversible methods of contraception if used correctly R it doesn’t interrupt sex R it usually makes your periods regular, lighter and less painful R it may help with pre-menstrual symptoms. Femodene will not protect you against sexually transmitted infections, such as Chlamydia or HIV. Only condoms can help to do this. Femodene needs to be taken as directed to prevent pregnancy.

2. What you need to know before you use Femodene General notes Before you start using Femodene you should read the information on blood clots in section 2. It is particularly important to read the symptoms of a blood clot – see Section 2.3 ‘Blood clots’. It’s important that you understand the benefits and risks of taking the Pill before you start taking it, or when deciding whether to carry on taking it. Although the Pill is suitable for most healthy women it isn’t suitable for everyone. B Tell your doctor if you have any of the illnesses or risk factors mentioned in this leaflet. Before you start taking the Pill R Your doctor will ask about you and your family’s medical problems, check your blood pressure and exclude the likelihood of you being pregnant. You may also need other checks, such as a breast examination, but only if these examinations are necessary for you, or if you have any special concerns. While you’re on the Pill R You will need regular check-ups with your doctor or family planning nurse, usually when you need another prescription of the Pill. R You should go for regular cervical smear tests. R Check your breasts and nipples every month for changes – tell your doctor if you can see or feel anything odd, such as lumps or dimpling of the skin. R If you need a blood test tell your doctor that you are taking the Pill, because the Pill can affect the results of some tests. R If you’re going to have an operation, make sure your doctor knows about it. You may need to stop taking the Pill about 4–6 weeks before the operation. This is to reduce the risk of a blood clot (see section 2.3). Your doctor will tell you when you can start taking the Pill again.

2.1 When you should not use Femodene You should not use Femodene if you have any of the conditions listed below. If you do have any of the conditions listed below, you must tell your doctor. Your doctor will discuss with you what other form of birth control would be more appropriate. Do not take Femodene: R If you have (or have ever had) a blood clot in a blood vessel of your legs (deep vein thrombosis, DVT), your lungs (pulmonary embolus, PE) or other organs R If you know you have a disorder affecting your blood clotting – for instance, protein C deficiency, protein S deficiency, antithrombin-III deficiency, Factor V Leiden or antiphospholipid antibodies R If you need an operation or if you are off your feet for a long time (see section 2.3 ‘Blood clots’)

R If you have ever had a heart attack or stroke R If you have (or have ever had) angina pectoris (a condition that causes severe chest pain and may be a first sign of a heart attack) or transient ischaemic attack (TIA – temporary stroke symptoms) R If you have any of the following diseases that may increase your risk of a clot in the arteries: P severe diabetes with blood vessel damage P very high blood pressure P a very high level of fat in the blood (cholesterol or triglycerides) P a condition known as hyperhomocysteinaemia R If you have (or have ever had) a type of migraine called ‘migraine with aura’ R If you have or have ever had breast cancer R If you have ever had a severe liver disease, and you have been told by your doctor that your liver function test results are not yet back to normal R If you have ever had liver tumours R If you are allergic (hypersensitive) to any of the ingredients in Femodene. B Tell your doctor or family planning nurse if you have any medical problems or illnesses

2.2 When to take special care with Femodene When should you contact your doctor? Seek urgent medical attention R if you notice possible signs of a blood clot that may mean you are suffering from a blood clot in the leg (i. e. deep vein thrombosis), a blood clot in the lung (i. e. pulmonary embolism), a heart attack or a stroke (see ‘Blood clots’ section below). For a description of the symptoms of these serious side effects please go to ‘How to recognise a blood clot’. Some of the conditions listed below can be made worse by taking the Pill. Or they may mean it is less suitable for you. You may still be able to take Femodene but you need to take special care and have check-ups more often. Tell your doctor if any of the following conditions apply to you. If the condition develops, or gets worse while you are using Femodene, you should also tell your doctor. R If you have Crohn’s disease or ulcerative colitis (chronic inflammatory bowel disease) R If you have systemic lupus erythematosus (SLE – a disease affecting your natural defence system) R If you have haemolytic uraemic syndrome (HUS – a disorder of blood clotting causing failure of the kidneys) R If you have sickle cell anaemia (an inherited disease of the red blood cells) R If you have inflammation of the pancreas (pancreatitis) R If you have elevated levels of fat in the blood (hypertriglyceridaemia) or a positive family history for this condition. Hypertriglyceridaemia has been associated with an increased risk of developing pancreatitis (inflammation of the pancreas) R If you need an operation, or you are off your feet for a long time (see in section 2.3 ‘Blood clots’) R If you have just given birth you are at an increased risk of blood clots. You should ask your doctor how soon after delivery you can start taking Femodene R If you have an inflammation in the veins under the skin (superficial thrombophlebitis) R If you have varicose veins R If you have diabetes R If you or your close family have ever had problems with your heart, or circulation such as high blood pressure R If you or your close family have ever had problems with blood clotting R If you have the inherited disease called porphyria R If you are overweight (obese)

R If you have migraines R If you have any illness that worsened during pregnancy or previous use of the Pill (see section 4.2)

Are you experiencing any of these signs?

What are you possibly suffering from?

2.3 Blood clots Using a combined hormonal contraceptive such as Femodene increases your risk of developing a blood clot compared with not using one. In rare cases a blood clot can block vessels and cause serious problems. Blood clots can develop: R in veins (referred to as a ‘venous thrombosis’, ‘venous thromboembolism’ or VTE); R in the arteries (referred to as an ‘arterial thrombosis’, ‘arterial thromboembolism’ or ATE). Recovery from blood clots is not always complete. Rarely, there may be serious lasting effects or, very rarely, they may be fatal. It is important to remember that the overall risk of having a harmful blood clot due to Femodene is small. HOW TO RECOGNISE A BLOOD CLOT Seek urgent medical attention if you notice any of the following signs or symptoms. Are you experiencing any of these signs? What are you possibly suffering from? R swelling of one leg or along a vein in the leg or Deep vein foot especially when accompanied by: thrombosis P pain or tenderness in the leg which may be felt only when standing or walking P increased warmth in the affected leg P change in colour of the skin on the leg e. g. turning pale, red or blue R sudden unexplained breathlessness or rapid Pulmonary breathing embolism R sudden cough without an obvious cause, which may bring up blood R sharp chest pain which may increase with deep breathing R severe light headedness or dizziness R rapid or irregular heartbeat R severe pain in your stomach If you are unsure, talk to a doctor as some of these symptoms such as coughing or being short of breath may be mistaken for a milder condition such as a respiratory tract infection (e. g. a ‘common cold’). Symptoms most commonly occur in one eye: Retinal vein thrombosis (blood clot in the eye) R immediate loss of vision or R painless blurring of vision which can progress to loss of vision R chest pain, discomfort, pressure, heaviness Heart attack R sensation of squeezing or fullness in the chest, arm or below the breastbone R fullness, indigestion or choking feeling R upper body discomfort radiating to the back, jaw, throat, arm and stomach R sweating, nausea, vomiting or dizziness R extreme weakness, anxiety, or shortness of breath R rapid or irregular heartbeats R sudden weakness or numbness of the face, Stroke arm or leg, especially on one side of the body R sudden confusion, trouble speaking or understanding R sudden trouble seeing in one or both eyes R sudden trouble walking, dizziness, loss of balance or coordination

R sudden, severe or prolonged headache with no known cause R loss of consciousness or fainting with or without seizure Sometimes the symptoms of stroke can be brief with an almost immediate and full recovery, but you should still seek urgent medical attention as you may be at risk of another stroke. R swelling and slight blue discolouration of an extremity

Blood clots blocking other blood vessels

R severe pain in your stomach (acute abdomen) B See a doctor as soon as possible. Do not take any more Femodene until your doctor says you can. Use another method of contraception, such as condoms, in the meantime. BLOOD CLOTS IN A VEIN What can happen if a blood clot forms in a vein? R The use of combined hormonal contraceptives has been connected with an increase in the risk of blood clots in the vein (venous thrombosis). However, these side effects are rare. Most frequently, they occur in the first year of use of a combined hormonal contraceptive. R If a blood clot forms in a vein in the leg or foot it can cause a deep vein thrombosis (DVT). R If a blood clot travels from the leg and lodges in the lung it can cause a pulmonary embolism. R Very rarely a clot may form in a vein in another organ such as the eye (retinal vein thrombosis). When is the risk of developing a blood clot in a vein highest? The risk of developing a blood clot in a vein is highest during the first year of taking a combined hormonal contraceptive for the first time. The risk may also be higher if you restart taking a combined hormonal contraceptive (the same product or a different product) after a break of 4 weeks or more. After the first year, the risk gets smaller but is always slightly higher than if you were not using a combined hormonal contraceptive. When you stop Femodene your risk of a blood clot returns to normal within a few weeks. What is the risk of developing a blood clot? The risk depends on your natural risk of VTE and the type of combined hormonal contraceptive you are taking. The overall risk of a blood clot in the leg or lung (DVT or PE) with Femodene is small. R Out of 10,000 women who are not using any combined hormonal contraceptive and are not pregnant, about 2 will develop a blood clot in a year. R Out of 10,000 women who are using a combined hormonal contraceptive that contains levonorgestrel, norethisterone, or norgestimate about 5-7 will develop a blood clot in a year. R Out of 10,000 women who are using a combined hormonal contraceptive that contains gestodene such as Femodene, between about 9 and 12 women will develop a blood clot in a year. R The risk of having a blood clot will vary according to your personal medical history (see ‘Factors that increase your risk of a blood clot in a vein’ below).

Women who are not using a combined hormonal pill and are not pregnant Women using a combined hormonal contraceptive pill containing levonorgestrel, norethisterone or norgestimate Women using Femodene

Risk of developing a blood clot in a year About 2 out of 10,000 women About 5-7 out of 10,000 women

About 9-12 out of 10,000 women

Factors that increase your risk of a blood clot in a vein The risk of a blood clot with Femodene is small but some conditions will increase the risk. Your risk is higher: R if you are very overweight (body mass index or BMI over 30kg/ m2 ) R if one of your immediate family has had a blood clot in the leg, lung or other organ at a young age (e. g. below the age of about 50). In this case you could have a hereditary blood clotting disorder R if you need to have an operation, or if you are off your feet for a long time because of an injury or illness, or you have your leg in a cast. The use of Femodene may need to be stopped several weeks before surgery or while you are less mobile. If you need to stop Femodene ask your doctor when you can start using it again. R as you get older (particularly above about 35 years) R if you gave birth less than a few weeks ago. The risk of developing a blood clot increases the more conditions you have. Air travel (>4 hours) may temporarily increase your risk of a blood clot, particularly if you have some of the other factors listed. It is important to tell your doctor if any of these conditions apply to you, even if you are unsure. Your doctor may decide that Femodene needs to be stopped. If any of the above conditions change while you are using Femodene, for example a close family member experiences a thrombosis for no known reason, or you gain a lot of weight, tell your doctor. BLOOD CLOTS IN AN ARTERY What can happen if a blood clot forms in an artery? Like a blood clot in a vein, a clot in an artery can cause serious problems. For example, it can cause a heart attack or a stroke. Factors that increase your risk of a blood clot in an artery It is important to note that the risk of a heart attack or stroke from using Femodene is very small but can increase: R with increasing age (beyond about 35 years) R if you smoke. When using a combined hormonal contraceptive like Femodene, you are advised to stop smoking. If you are unable to stop smoking and are older than 35 your doctor may advise you to use a different type of contraceptive R if you are overweight R if you have high blood pressure R if a member of your immediate family has had a heart attack or stroke at a young age (less than about 50). In this case you could also have a higher risk of having a heart attack or stroke R if you, or someone in your immediate family, have a high level of fat in the blood (cholesterol or triglycerides) R if you get migraines, especially migraines with aura R if you have a problem with your heart (valve disorder, disturbance of the rhythm called atrial fibrillation) R if you have diabetes. If you have more than one of these conditions or if any of them are particularly severe the risk of developing a blood clot may be increased even more. If any of the above conditions change while you are using Femodene, for example you start smoking, a close family member experiences a thrombosis for no known reason, or you gain a lot of weight, tell your doctor.

2.4 The Pill and cancer While high dose Pills reduce your risk of cancer of the ovary and womb if used in the long term, it is not clear whether lower dose Pills like Femodene also provide the same protective effects. However, it also seems that taking the Pill slightly increases your risk of cancer of the cervix – although this may be due to having sex without a condom, rather than the Pill. All women should have regular smear tests. If you have breast cancer, or have had it in the past, you should not take the Pill. The Pill slightly increases your risk of breast cancer. This risk goes up the longer you’re on the Pill, but returns to normal within about 10 years of stopping it. Because breast cancer is rare in women under the age of 40, the extra cases of

breast cancer in current and recent Pill users is small. For example: R Of 10,000 women who have never taken the Pill, about 16 will have breast cancer by the time they are 35 years old. R Of 10,000 women who take the Pill for 5 years in their early twenties, about 17–18 will have breast cancer by the time they are 35 years old. R Of 10,000 women who have never taken the Pill, about 100 will have breast cancer by the time they are 45 years old. R Of 10,000 women who take the Pill for 5 years in their early thirties, about 110 will have breast cancer by the time they are 45 years old. Your risk of breast cancer is higher: R if you have a close relative (mother, sister or grandmother) who has had breast cancer R if you are seriously overweight B See a doctor as soon as possible if you notice any changes in your breasts, such as dimpling of the skin, changes in the nipple or any lumps you can see or feel. Taking the Pill has also been linked to liver diseases, such as jaundice and non-cancer liver tumours, but this is rare. Very rarely, the Pill has also been linked with some forms of liver cancer in women who have taken it for a long time. B See a doctor as soon as possible if you get severe pain in your stomach, or yellow skin or eyes (jaundice). You may need to stop taking Femodene.

2.5 Taking other medicines If you ever need to take another medicine at the same time as being on the Pill, always tell your doctor, pharmacist or dentist that you’re taking Femodene. Also check the leaflets that come with all your medicines to see if they can be taken with hormonal contraceptives. Some medicines can have an influence on the blood levels of Femodene and can stop it from working properly – for example: R some medicines used to treat epilepsy R some medicines used to treat HIV and Hepatitis C Virus infections (so-called protease inhibitors and non-nucleoside reverse transcriptase inhibitors) R griseofulvin (an anti-fungal medicine) R certain antibiotics R certain sedatives (called ‘barbiturates’) R St. John’s Wort (a herbal remedy). If you do need to take one of these medicines, Femodene may not be suitable for you or you may need to use extra contraception for a while. Your doctor, pharmacist or dentist can tell you if this is necessary and for how long. Femodene can also affect how well other medicines work. Your doctor may need to adjust the dose of your other medicine. In addition, Femodene can also interfere with the results of some blood tests, so always tell your doctor that you are taking Femodene if you have a blood test.

2.6 Taking Femodene with food and drink There are no special instructions about food and drink while on Femodene.

2.7 Pregnancy and breast-feeding Do not use Femodene if you are pregnant. If you think you might be pregnant, do a pregnancy test to confirm that you are before you stop taking Femodene. If you are breast-feeding, your doctor or family planning nurse may advise you not to take Femodene. They will be able to suggest alternative contraception. Breast-feeding may not stop you getting pregnant.

2.8 Driving and using machines Femodene has no known effect on the ability to drive or use machines.

2.9 Femodene contains lactose and sucrose If you have been told by your doctor that you have intolerance to some sugars, contact your doctor before using Femodene.

Packaging Technology Berlin sgqwx page 1 Bayer Pharma AG client: JS86 material-no. 85182528 PZ: 2709W-3 code-no. 103 name: LF-INS-Femodene SCT 21 GB country: GB/-/BPH colors: Black version: 19.02.2016/03 approval: dimension: 266 x 677 mm

This area must be identical on both sides! 3. Taking Femodene 3.1 How to take it To prevent pregnancy, always take Femodene as described below. Check with your doctor or family planning nurse if you are not sure. Take Femodene every day for 21 days Femodene comes in strips of 21 pills, each marked with a day of the week. R Take your pill at the same time every day. R Start by taking a pill marked with the correct day of the week. R Follow the direction of the arrows on the strip. Take one pill each day, until you have finished all 21 pills. R Swallow each pill whole, with water if necessary. Do not chew the pill. Then have seven pill-free days After you have taken all 21 pills in the strip, you have seven days when you take no pills. So, if you take the last pill of one pack on a Friday, you will take the first pill of your next pack on the Saturday of the following week. Within a few days of taking the last pill from the strip, you should have a withdrawal bleed like a period. This bleed may not have finished when it is time to start your next strip of pills. You don’t need to use extra contraception during these seven pillfree days – as long as you have taken your pills correctly and start the next strip of pills on time. Then start your next strip Start taking your next strip of Femodene after the seven pill-free days – even if you are still bleeding. Always start the new strip on time. As long as you take Femodene correctly, you will always start each new strip on the same day of the week.

3.2 Starting Femodene As a new user or starting the Pill again after a break It is best to take your first Femodene pill on the first day of your next period. By starting in this way, you will have contraceptive protection with your first pill. Changing to Femodene from another contraceptive Pill R If you are currently on a 21-day Pill: start Femodene the next day after the end of the previous strip. You will have contraceptive protection with your first pill. You will not have a bleed until after your first strip of Femodene. R If you are currently on a 28-day Pill: start taking Femodene the day after your last active pill. You will have contraceptive protection with your first pill. You will not have a bleed until after your first strip of Femodene. R Or, if you are taking a progestogen-only Pill (POP or ‘mini Pill’): start Femodene on the first day of bleeding, even if you have already taken the progestogen-only Pill for that day. You will have contraceptive cover straight away. Starting Femodene after a miscarriage or abortion If you have had a miscarriage or an abortion during the first three months of pregnancy, your doctor may tell you to start taking Femodene straight away. This means that you will have contraceptive protection with your first pill. If you have had a miscarriage or an abortion after the third month of pregnancy, ask your doctor for advice. You may need to use extra contraception, such as condoms, for a short time. Contraception after having a baby If you have just had a baby, your doctor may advise you that Femodene should be started 21 days after delivery provided that you are fully mobile. You do not have to wait for a period. You will need to use another method of contraception, such as a condom, until you start Femodene and for the first 7 days of pill taking.

3.3 A missed pill If you are less than 12 hours late with a pill, take it straight away. Keep taking your pills at the usual time. This may mean taking two pills in one day. Don’t worry – your contraceptive protection should not be reduced.

If you are more than 12 hours late with a pill, or you have missed more than one pill, your contraceptive protection may be reduced. R Take the most recently missed pill as soon as you remember, even if it means taking two at once. Leave any earlier missed pills in the pack. R Continue to take a pill every day for the next seven days at your usual time. R If you come to the end of a strip of pills during these seven days, start the next strip without taking the usual seven day break. You probably won’t have a bleed until after you finish the second strip of pills, but don’t worry. If you finish the second strip of pills and don’t have a bleed, do a pregnancy test before starting another strip. R Use extra contraception for seven days after missing a pill, such as condoms. R If you have missed one or more pills from the first week of your strip (days 1 to 7) and you had sex in that week, you could become pregnant. Contact your doctor, family planning nurse or pharmacist for advice as soon as possible. They may recommend you use emergency contraception. If you have missed any of the pills in a strip, and you do not bleed in the first pill-free break, you may be pregnant. Contact your doctor or family planning clinic, or do a pregnancy test yourself. If you start a new strip of pills late, or make your ‘week off’ longer than seven days, you may not be protected from pregnancy. If you had sex in the last seven days, ask your doctor, family planning nurse or pharmacist for advice. You may need to consider emergency contraception. You should also use extra contraception, such as a condom, for seven days.

3.4 A lost pill If you lose a pill, Either take the last pill of the strip in place of the lost pill. Then take all the other pills on their proper days. Your cycle will be one day shorter than normal, but your contraceptive protection won’t be affected. After your seven pill-free days you will have a new starting day, one day earlier than before. Or if you do not want to change the starting day of your cycle, take a pill from a spare strip if you have one. Then take all the other pills from your current strip as usual. You can then keep the opened spare strip in case you lose any more pills.

3.5 If you are sick or have diarrhoea If you are sick (vomit) or have very bad diarrhoea within 4 hours of taking the Pill, your body may not get its usual dose of hormones from that pill. If you are better within 12 hours of taking Femodene, follow the instructions in section 3.4 A lost pill, which describes how to take another pill. If you are still sick or have diarrhoea more than 12 hours after taking Femodene, see section 3.3, A missed pill. B Talk to your doctor if your stomach upset carries on or gets worse. He or she may recommend another form of contraception. Packaging Technology Berlin sgqwx page 2 Bayer Pharma AG client: JS86 material-no. 85182528 PZ: 2709W-3 code-no. 103 name: LF-INS-Femodene SCT 21 GB country: GB/-/BPH colors: Black version: 19.02.2016/03 approval: dimension: 266 x 677 mm

3.6 Missed a period – could you be pregnant? Occasionally, you may miss a withdrawal bleed. This could mean that you are pregnant, but that is very unlikely if you have taken your pills correctly. Start your next strip at the normal time. If you think that you might have put yourself at risk of pregnancy (for example, by missing pills or taking other medicines), or if you miss a second bleed, you should do a pregnancy test. You can buy these from the chemist or get a free test at your family planning clinic or doctors surgery. If you are pregnant, stop taking Femodene and see your doctor.

3.7 Taking more than one pill should not cause harm It is unlikely that taking more than one pill will do you any harm, but you may feel sick, vomit or have some vaginal bleeding. Talk to your doctor if you have any of these symptoms.

3.8 When you want to get pregnant If you are planning a baby, it’s best to use another method of contraception after stopping Femodene until you have had a proper period. Your doctor or midwife relies on the date of your last natural period to tell you when your baby is due. However, it

This area must be identical on both sides! will not cause you or the baby any harm if you get pregnant straight away.

4. Possible side effects Like all medicines, Femodene can cause side effects, although not everybody gets them. If you get any side effect, particularly if severe and persistent, or have any change to your health that you think may be due to Femodene, please talk to your doctor. An increased risk of blood clots in the veins (venous thromboembolism (VTE)) or blood clots in the arteries (arterial thromboembolism (ATE)) is present for all women using combined hormonal contraceptives. For more detailed information on the different risks from taking combined hormonal contraceptives please see section 2 “What you need to know before you use Femodene”. B Tell your doctor, pharmacist or family planning nurse if you are worried about any side effects which you think may be due to Femodene.

4.1 Serious side effects – see a doctor straight away Rare side effects (between 1 and 10 in every 10,000 users may be affected) R harmful blood clots in a vein or artery for example: P in a leg or foot (i. e. DVT) P in a lung (i. e. PE) P heart attack P stroke P mini-stroke or temporary stroke-like symptoms, known as a transient ischaemic attack (TIA) P blood clots in the liver, stomach/intestine, kidneys or eye. The chance of having a blood clot may be higher if you have any other conditions that increase this risk (see section 2 for more information on the conditions that increase risk for blood clots and the symptoms of a blood clot). Signs of a blood clot (see section 2.3 ‘Blood clots’) Signs of a severe allergic reaction or worsening of hereditary angioedema: R swelling of the hands, face, lips, mouth, tongue or throat. A swollen tongue/throat may lead to difficulty swallowing and breathing R a red bumpy rash (hives) and itching. Signs of breast cancer include: R dimpling of the skin R changes in the nipple R any lumps you can see or feel. Signs of cancer of the cervix include: R vaginal discharge that smells and/or contains blood R unusual vaginal bleeding R pelvic pain R painful sex. Signs of severe liver problems include: R severe pain in your upper abdomen R yellow skin or eyes (jaundice) R inflammation of the liver (hepatitis) R your whole body starts itching. B If you think you may have any of these, see a doctor straight away. You may need to stop taking Femodene.

4.2 Less serious side effects Common side effects (between 100 and 1000 in every 10,000 users may be affected) R feeling sick R stomach ache R putting on weight R headaches R depressive moods or mood swings R sore or painful breasts Uncommon side effects (between 10 and 100 in every 10,000 users may be affected) R being sick and stomach upsets R fluid retention

R migraine R loss of interest in sex R breast enlargement R skin rash, which may be itchy Rare side effects (between 1 and 10 in every 10,000 users may be affected) R poor tolerance of contact lenses R losing weight R increase of interest in sex R vaginal or breast discharge Other side effects reported R Bleeding and spotting between your periods can sometimes occur for the first few months but this usually stops once your body has adjusted to Femodene. If it continues, becomes heavy or starts again, contact your doctor (see section 4.3). R Chloasma (yellow brown patches on the skin). This may happen even if you have been using Femodene for a number of months. Chloasma may be reduced by avoiding too much sunlight and/or UV lamps R Occurrence or deterioration of the movement disorder chorea R Ulcerative colitis R Conditions that may worsen during pregnancy or previous use of the Pill: P yellowing of the skin (jaundice) P persistent itching (pruritus) P kidney or liver problems P gall stones P certain rare medical conditions such as systemic lupus erythematosus P blister-like rash (herpes gestationis) whilst pregnant P an inherited form of deafness (otosclerosis) P Crohn’s disease P a personal or family history of a form of sickle cell disease P swelling of body parts (hereditary angioedema) P an inherited disease called porphyria P cancer of the cervix B Tell your doctor, pharmacist or family planning nurse if you are worried about any side effects which you think may be due to Femodene. Also tell them if any existing conditions get worse while you are taking Femodene.

Do not throw away any medicines down a drain or into a bin. Ask your pharmacist what to do with any medicines you do not want. This will help to protect the environment.

6. What is in Femodene and who makes it

What is in Femodene Each box of Femodene contains three strips of 21 white tablets containing 75 micrograms of the progestogen gestodene, and 30 micrograms of the oestrogen ethinylestradiol. Femodene also contains the inactive ingredients: Lactose, maize starch, povidone, magnesium stearate (E572), sodium calcium edetate, sucrose, macrogol 6000, calcium carbonate (E170), talc, montan glycol wax. The company that holds the product licence for Femodene is: Bayer plc, Bayer House, Strawberry Hill, Newbury, Berkshire, RG14 1JA. Femodene is made by: Bayer Weimar GmbH & Co KG, Weimar, Germany or Delpharm Lille SAS, Lys-Lez-Lannoy, France. This leaflet was last updated in February 2016.

4.3 Bleeding between periods should not last long A few women have a little unexpected bleeding or spotting while they are taking Femodene, especially during the first few months. Normally, this bleeding is nothing to worry about and will stop after a day or two. Keep taking Femodene as usual. The problem should disappear after the first few strips. You may also have unexpected bleeding if you are not taking your pills regularly, so try to take your pill at the same time every day. Also, unexpected bleeding can sometimes be caused by other medicines. B Make an appointment to see your doctor if you get breakthrough bleeding or spotting that: R carries on for more than the first few months R starts after you’ve been taking Femodene for a while R carries on even after you’ve stopped taking Femodene. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.

5. How to store Femodene Keep all medicines out of the sight and reach of children. Do not use Femodene after the expiry date shown on the strip. Do not store above 25°C and protect from light. 85182528

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Percocet - Fda Prescribing Information, Side Effects And Uses, Percocet

Percocet

WARNING: ADDICTION, ABUSE, AND MISUSE; LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL INGESTION; NEONATAL OPIOID WITHDRAWAL SYNDROME; CYTOCHROME P450 3A4 INTERACTION; and HEPATOTOXICITY

Addiction, Abuse, and Misuse

Percocet exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient’s risk prior to prescribing Percocet and monitor all patients regularly for the development of these behaviors or conditions (see WARNINGS ).

Life-Threatening Respiratory Depression

Serious, life-threatening, or fatal respiratory depression may occur with use of Percocet. Monitor for respiratory depression, especially during initiation of Percocet or following a dose increase (see WARNINGS ).

Accidental ingestion of even one dose of Percocet, especially by children, can result in a fatal overdose of Percocet (see WARNINGS ).

Neonatal Opioid Withdrawal Syndrome

Prolonged use of Percocet during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available (see WARNINGS ).

Cytochrome P450 3A4 Interaction

The concomitant use of Percocet with all cytochrome P450 3A4 inhibitors may result in an increase in Percocet plasma concentrations, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression. In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in Percocet plasma concentration. Monitor patients receiving Percocet and any CYP3A4 inhibitor or inducer (see CLINICAL PHARMACOLOGY. WARNINGS. PRECAUTIONS; Drug Interactions ).

Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen-containing product (see WARNINGS ; PRECAUTIONS ; ADVERSE REACTIONS ; OVERDOSAGE ) .

Percocet Description

Each tablet, for oral administration, contains oxycodone hydrochloride and acetaminophen in the following strengths:

Oxycodone Hydrochloride, USP 2.5 mg* Acetaminophen, USP 325 mg *2.5 mg oxycodone HCl is equivalent to 2.2409 mg of oxycodone.

Oxycodone Hydrochloride, USP 5 mg* Acetaminophen, USP 325 mg *5 mg oxycodone HCl is equivalent to 4.4815 mg of oxycodone.

Oxycodone Hydrochloride, USP 7.5 mg* Acetaminophen, USP 325 mg *7.5 mg oxycodone HCl is equivalent to 6.7228 mg of oxycodone.

Oxycodone Hydrochloride, USP 10 mg* Acetaminophen, USP 325 mg *10 mg oxycodone HCl is equivalent to 8.9637 mg of oxycodone.

All strengths of Percocet also contain the following inactive ingredients: Colloidal silicon dioxide, croscarmellose sodium, crospovidone, microcrystalline cellulose, povidone, pregelatinized cornstarch, and stearic acid. In addition, the 2.5 mg/325 mg strength contains FD&C Red No. 40 Aluminum Lake and the 5 mg/325 mg strength contains FD&C Blue No. 1 Aluminum Lake. The 7.5 mg/325 mg strength contains FD&C Yellow No. 6 Aluminum Lake. The 10 mg/325 mg strength contains D&C Yellow No. 10 Aluminum Lake. The 7.5 mg/325 mg strength and the 10 mg/325 mg strength may also contain corn starch.

Oxycodone, 14-hydroxydihydrocodeinone, is a semisynthetic opioid analgesic which occurs as a white, odorless, crystalline powder having a saline, bitter taste. The molecular formula for oxycodone hydrochloride is C 18 H 21 NO 4 •HCl and the molecular weight 351.82. It is derived from the opium alkaloid thebaine, and may be represented by the following structural formula:

Acetaminophen, 4’-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic and antipyretic which occurs as a white, odorless, crystalline powder, possessing a slightly bitter taste. The molecular formula for acetaminophen is C 8 H 9 NO 2 and the molecular weight is 151.17. It may be represented by the following structural formula:

Percocet - Clinical Pharmacology

Central Nervous System

Oxycodone is a semisynthetic pure opioid agonist whose principal therapeutic action is analgesia. Other pharmacological effects of oxycodone include anxiolysis, euphoria and feelings of relaxation. These effects are mediated by receptors (notably µ and κ) in the central nervous system for endogenous opioid-like compounds such as endorphins and enkephalins. Oxycodone produces respiratory depression through direct activity at respiratory centers in the brain stem and depresses the cough reflex by direct effect on the center of the medulla.

Acetaminophen is a non-opiate, non-salicylate analgesic and antipyretic. The site and mechanism for the analgesic effect of acetaminophen has not been determined. The antipyretic effect of acetaminophen is accomplished through the inhibition of endogenous pyrogen action on the hypothalamic heat-regulating centers.

Gastrointestinal Tract and Other Smooth Muscle

Oxycodone reduces motility by increasing smooth muscle tone in the stomach and duodenum. In the small intestine, digestion of food is delayed by decreases in propulsive contractions. Other opioid effects include contraction of biliary tract smooth muscle, spasm of the Sphincter of Oddi, increased ureteral and bladder sphincter tone, and a reduction in uterine tone.

Cardiovascular System

Oxycodone may produce a release of histamine and may be associated with orthostatic hypotension, and other symptoms, such as pruritus, flushing, red eyes, and sweating.

Pharmacokinetics

Absorption and Distribution

The mean absolute oral bioavailability of oxycodone in cancer patients was reported to be about 87%. Oxycodone has been shown to be 45% bound to human plasma proteins in vitro. The volume of distribution after intravenous administration is 211.9 ±186.6 L.

Absorption of acetaminophen is rapid and almost complete from the GI tract after oral administration. With overdosage, absorption is complete in 4 hours. Acetaminophen is relatively uniformly distributed throughout most body fluids. Binding of the drug to plasma proteins is variable; only 20% to 50% may be bound at the concentrations encountered during acute intoxication.

Metabolism and Elimination

A high portion of oxycodone is N-dealkylated to noroxycodone during first-pass metabolism. Oxymorphone, is formed by the O-demethylation of oxycodone. The metabolism of oxycodone to oxymorphone is catalyzed by CYP2D6. Free and conjugated noroxycodone, free and conjugated oxycodone, and oxymorphone are excreted in human urine following a single oral dose of oxycodone. Approximately 8% to 14% of the dose is excreted as free oxycodone over 24 hours after administration. Following a single, oral dose of oxycodone, the mean ± SD elimination half-life is 3.51 ± 1.43 hours.

Acetaminophen is metabolized in the liver via cytochrome P450 microsomal enzyme. About 80-85% of the acetaminophen in the body is conjugated principally with glucuronic acid and to a lesser extent with sulfuric acid and cysteine. After hepatic conjugation, 90 to 100% of the drug is recovered in the urine with in the first day.

About 4% of acetaminophen is metabolized via cytochrome P450 oxidase to a toxic metabolite which is further detoxified by conjugation with glutathione, present in a fixed amount. It is believed that the toxic metabolite NAPQI (N acetyl-p-benzoquinoneimine, N-acetylimidoquinone) is responsible for liver necrosis. High doses of acetaminophen may deplete the glutathione stores so that inactivation of the toxic metabolite is decreased. At high doses, the capacity of metabolic pathways for conjugation with glucuronic acid and sulfuric acid may be exceeded, resulting in increased metabolism of acetaminophen by alternate pathways.

Indications and Usage for Percocet

Percocet is indicated for the management of moderate to moderately severe pain, severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Limitations of Use

Because of the risks of addiction, abuse, and misuse, with opioids, even at recommended doses (see WARNINGS ), reserve Percocet for use in patients for whom alternative treatment options (e. g. non-opioid analgesics)

Have not been tolerated, or are not expected to be tolerated,

Have not provided adequate analgesia, or are not expected to provide adequate analgesia

Contraindications

Percocet is contraindicated in patients with:

Significant respiratory depression (see WARNINGS )

Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment (see WARNINGS )

Known hypersensitivity to oxycodone, acetaminophen, or any other component of this product

Hypercarbia

Known or suspected paralytic ileus

Warnings

Addiction, Abuse, and Misuse

Percocet contains Oxycodone, a Schedule II controlled substance. As an opioid, Percocet exposes users to the risks of addiction, abuse, and misuse (see DRUG ABUSE AND DEPENDENCE ).

Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed Percocet. Addiction can occur at recommended dosages and if the drug is misused or abused.

Assess each patient’s risk for opioid addiction, abuse, or misuse prior to prescribing Percocet, and monitor all patients receiving Percocet for the development of these behaviors or conditions. Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e. g. major depression). The potential for these risks should not, however, prevent the proper management of pain in any given patient. Patients at increased risk may be prescribed opioids such as Percocet, but use in such patients necessitates intensive counseling about the risks and proper use of Percocet along with intensive monitoring for signs of addiction, abuse, and misuse.

Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing Percocet. Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity and advising the patient on the proper disposal of unused drug (see PRECAUTIONS ; Information for Patients ). Contact local state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product.

Life-Threatening Respiratory Depression

Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used as recommended. Respiratory depression, if not immediately recognized and treated, may lead to respiratory arrest and death. Management of respiratory depression may include close observation, supportive measures, and use of opioid antagonists, depending on the patient’s clinical status (see OVERDOSAGE ). Carbon dioxide (CO 2 ) retention from opioid-induced respiratory depression can exacerbate the sedating effects of opioids.

While serious, life-threatening, or fatal respiratory depression can occur at any time during the use of Percocet, the risk is greatest during the initiation of therapy or following a dosage increase. Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy with and following dosage increases of Percocet.

To reduce the risk of respiratory depression, proper dosing and titration of Percocet are essential (see DOSAGE AND ADMINISTRATION ). Overestimating the Percocet dosage when converting patients from another opioid product can result in a fatal overdose with the first dose.

Accidental ingestion of even one dose of Percocet, especially by children can result in respiratory depression and death due to an overdose of oxycodone.

Neonatal Opioid Withdrawal Syndrome

Prolonged use of Percocet during pregnancy can result in withdrawal in the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available (see PRECAUTIONS ; Information for Patients. Pregnancy ).

Risks of Concomitant Use or Discontinuation of Cytochrome P450 3A4 Inhibitors and Inducers

Concomitant use of Percocet with a CYP3A4 inhibitor, such as macrolide antibiotics (e. g. erythromycin), azole-antifungal agents (e. g. ketoconazole), and protease inhibitors (e. g. ritonavir), may increase plasma concentrations of Percocet and prolong opioid adverse reactions, which may cause potentially fatal respiratory depression (see WARNINGS ), particularly when an inhibitor is added after a stable dose of Percocet is achieved. Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in Percocet-treated patients may increase Percocet plasma concentrations and prolong opioid adverse reactions. When using Percocet with CYP3A4 inhibitors or discontinuing CYP3A4 inducers in Percocet-treated patients, monitor patients closely at frequent intervals and consider dosage reduction of Percocet until stable drug effects are achieved (see PRECAUTIONS; Drug Interactions ).

Concomitant use of Percocet with CYP3A4 inducers or discontinuation of an CYP3A4 inhibitor could decrease Percocet plasma concentrations, decrease opioid efficacy or, possibly, lead to a withdrawal syndrome in a patient who had developed physical dependence to Percocet. When using Percocet with CYP3A4 inducers or discontinuing CYP3A4 inhibitors, monitor patients closely at frequent intervals and consider increasing the opioid dosage if needed to maintain adequate analgesia or if symptoms of opioid withdrawal occur (see PRECAUTIONS; Drug Interactions ).

Risks due to Interactions with Central Nervous System Depressants

Hypotension, profound sedation, respiratory depression, coma, and death may result if Percocet is used concomitantly with alcohol or other central nervous system (CNS) depressants (e. g. benzodiazepines and other sedatives/hypnotics, anxiolytics, and tranquilizers, muscle relaxants, general anesthetics, antipsychotics, other opioids).

When considering the use of Percocet in a patient taking a CNS depressant, assess the duration of use of the CNS depressant and the patient’s response, including the degree of tolerance that has developed to CNS depression. Additionally, evaluate the patient’s use of alcohol or illicit drugs that can cause CNS depression. If the decision to begin Percocet tablets is made, start with a lower dosage of Percocet tablets, monitor patients for signs of respiratory depression, sedation, and hypotension, and consider using a lower dose of the concomitant CNS depressant (see PRECAUTIONS; Drug Interactions ).

Life-Threatening Respiratory Depression in Patients with Chronic Pulmonary Disease or in Elderly, Cachectic, or Debilitated Patients

The use of Percocet in patients with acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment is contraindicated.

Patients with Chronic Pulmonary Disease: Percocet-treated patients with significant chronic obstructive pulmonary disease or cor pulmonale, and those with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression are at increased risk of decreased respiratory drive including apnea, even at recommended dosages of Percocet (see WARNINGS ).

Elderly, Cachetic, or Debilitated Patients: Life-threatening respiratory depression is more likely to occur in elderly, cachectic, or debilitated patients because they may have altered pharmacokinetics or altered clearance compared to younger, healthier patients (see WARNINGS ).

Monitor such patients closely, particularly when initiating and titrating Percocet and when Percocet is given concomitantly with other drugs that depress respiration (see WARNINGS ). Alternatively, consider the use of non-opioid analgesics in these patients.

Adrenal Insufficiency

Cases of adrenal insufficiency have been reported with opioid use, more often following greater than 1 month of use. Presentation of adrenal insufficiency may include non-specific symptoms and signs including nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure. If adrenal insufficiency is suspected, confirm the diagnosis with diagnostic testing as soon as possible. If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. Wean the patient off of the opioid to allow adrenal function to recover and continue corticosteroid treatment until adrenal function recovers. Other opioids may be tried as some cases reported use of a different opioid without recurrence of adrenal insufficiency. The information available does not identify any particular opioids as being more likely to be associated with adrenal insufficiency.

Head Injury and Increased Intracranial Pressure

The respiratory depressant effects of opioids include carbon dioxide retention and secondary elevation of cerebrospinal fluid pressure, and may be markedly exaggerated in the presence of head injury, other intracranial lesions or a pre-existing increase in intracranial pressure. Oxycodone produces effects on pupillary response and consciousness which may obscure neurologic signs of worsening in patients with head injuries.

Hypotensive Effect

Oxycodone may cause severe hypotension particularly in individuals whose ability to maintain blood pressure has been compromised by a depleted blood volume, or after concurrent administration with drugs which compromise vasomotor tone such as phenothiazines. Oxycodone, like all opioid analgesics of the morphine-type, should be administered with caution to patients in circulatory shock, since vasodilation produced by the drug may further reduce cardiac output and blood pressure. Oxycodone may produce orthostatic hypotension in ambulatory patients.

Hepatotoxicity

Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen containing product. The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophen-containing products.

The risk of acute liver failure is higher in individuals with underlying liver disease and in individuals who ingest alcohol while taking acetaminophen.

Instruct patients to look for acetaminophen or APAP on package labels and not to use more than one product that contains acetaminophen. Instruct patients to seek medical attention immediately upon ingestion of more than 4000 milligrams of acetaminophen per day, even if they feel well.

Serious skin reactions

Rarely, acetaminophen may cause serious skin reactions such as acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. Patients should be informed about the signs of serious skin reactions, and use of the drug should be discontinued at the first appearance of skin rash or any other sign of hypersensitivity.

Hypersensitivity / anaphylaxis

There have been post-marketing reports of hypersensitivity and anaphylaxis associated with use of acetaminophen. Clinical signs including swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention. Instruct patients to discontinue Percocet immediately and seek medical care if they experience these symptoms. Do not prescribe Percocet for patients with acetaminophen allergy.

Precautions

General

Opioid analgesics should be used with caution when combined with CNS depressant drugs, and should be reserved for cases where the benefits of opioid analgesia outweigh the known risks of respiratory depression, altered mental state, and postural hypotension.

Acute Abdominal Conditions

The administration of Percocet (Oxycodone and Acetaminophen Tablets, USP) or other opioids may obscure the diagnosis or clinical course in patients with acute abdominal conditions.

Percocet tablets should be given with caution to patients with CNS depression, elderly or debilitated patients, patients with severe impairment of hepatic, pulmonary, or renal function, hypothyroidism, Addison's disease, prostatic hypertrophy, urethral stricture, acute alcoholism, delirium tremens, kyphoscoliosis with respiratory depression, myxedema, and toxic psychosis.

Percocet tablets may obscure the diagnosis or clinical course in patients with acute abdominal conditions. Oxycodone may aggravate convulsions in patients with convulsive disorders, and all opioids may induce or aggravate seizures in some clinical settings.

Following administration of Percocet tablets, anaphylactic reactions have been reported in patients with a known hypersensitivity to codeine, a compound with a structure similar to morphine and oxycodone. The frequency of this possible cross-sensitivity is unknown.

Interactions with Other CNS Depressants

Patients receiving other opioid analgesics, general anesthetics, phenothiazines, other tranquilizers, centrally-acting anti-emetics, sedative-hypnotics or other CNS depressants (including alcohol) concomitantly with Percocet tablets may exhibit an additive CNS depression. When such combined therapy is contemplated, the dose of one or both agents should be reduced.

Interactions with Mixed Agonist/Antagonist Opioid Analgesics

Agonist/antagonist analgesics (i. e. pentazocine, nalbuphine, and butorphanol) should be administered with caution to a patient who has received or is receiving a course of therapy with a pure opioid agonist analgesic such as oxycodone. In this situation, mixed agonist/antagonist analgesics may reduce the analgesic effect of oxycodone and/or may precipitate withdrawal symptoms in these patients.

Ambulatory Surgery and Postoperative Use

Oxycodone and other morphine-like opioids have been shown to decrease bowel motility. Ileus is a common postoperative complication, especially after intra-abdominal surgery with use of opioid analgesia. Caution should be taken to monitor for decreased bowel motility in postoperative patients receiving opioids. Standard supportive therapy should be implemented.

Use in Pancreatic/Biliary Tract Disease

Oxycodone may cause spasm of the Sphincter of Oddi and should be used with caution in patients with biliary tract disease, including acute pancreatitis. Opioids like oxycodone may cause increases in the serum amylase level.

Tolerance and Physical Dependence

Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia (in the absence of disease progression or other external factors). Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist. Physical dependence and tolerance are not unusual during chronic opioid therapy.

The opioid abstinence or withdrawal syndrome is characterized by some or all of the following: restlessness, lacrimation, rhinorrhea, yawning, perspiration, chills, myalgia, and mydriasis. Other symptoms also may develop, including: irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate.

Information for Patients

The following information should be provided to patients receiving Percocet tablets by their physician, nurse, pharmacist, or caregiver:

Do not take Percocet if you are allergic to any of its ingredients.

If you develop signs of allergy such as a rash or difficulty breathing stop taking Percocet and contact your healthcare provider immediately.

Do not take more than 4000 milligrams of acetaminophen per day. Call your doctor if you took more than the recommended dose.

Patients should be aware that Percocet tablets contain oxycodone, which is a morphine-like substance.

Patients should be instructed to keep Percocet tablets in a secure place out of the reach of children. In the case of accidental ingestions, emergency medical care should be sought immediately.

When Percocet tablets are no longer needed, the unused tablets should be destroyed by flushing down the toilet.

Patients should be advised not to adjust the medication dose themselves. Instead, they must consult with their prescribing physician.

Patients should be advised that Percocet tablets may impair mental and/or physical ability required for the performance of potentially hazardous tasks (e. g. driving, operating heavy machinery).

Patients should not combine Percocet tablets with alcohol, opioid analgesics, tranquilizers, sedatives, or other CNS depressants unless under the recommendation and guidance of a physician. When co-administered with another CNS depressant, Percocet tablets can cause dangerous additive central nervous system or respiratory depression, which can result in serious injury or death.

The safe use of Percocet tablets during pregnancy has not been established; thus, women who are planning to become pregnant or are pregnant should consult with their physician before taking Percocet tablets.

Nursing mothers should consult with their physicians about whether to discontinue nursing or discontinue Percocet tablets because of the potential for serious adverse reactions to nursing infants.

Patients who are treated with Percocet tablets for more than a few weeks should be advised not to abruptly discontinue the medication. Patients should consult with their physician for a gradual discontinuation dose schedule to taper off the medication.

Patients should be advised that Percocet tablets are a potential drug of abuse. They should protect it from theft, and it should never be given to anyone other than the individual for whom it was prescribed.

Addiction, Abuse, and Misuse Inform patients that the use of Percocet, even when taken as recommended, can result in addiction, abuse, and misuse, which can lead to overdose and death ( see WARNINGS ). Instruct patients not to share Percocet with others and to take steps to protect Percocet from theft or misuse.

Life-Threatening Respiratory Depression Inform patients of the risk of life-threatening respiratory depression, including information that the risk is greatest when starting Percocet or when the dosage is increased, and that it can occur even at recommended dosages (see WARNINGS ). Advise patients how to recognize respiratory depression and to seek medical attention if breathing difficulties develop.

Accidental Ingestion Inform patients that accidental ingestion, especially by children, may result in respiratory depression or death (see WARNINGS ). Instruct patients to take steps to store Percocet securely and to dispose of unused Percocet by flushing down the toilet.

Interactions with Alcohol and Other CNS Depressants Inform patients that potentially serious additive effects may occur if Percocet is used with alcohol or other CNS depressants and not to use such drugs unless supervised by a health care provider (see WARNINGS. PRECAUTIONS ; Drug Interactions ).

Serotonin Syndrome Inform patients that Percocet could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. Warn patients of the symptoms of serotonin syndrome and to seek medical attention right away if symptoms develop. Instruct patients to inform their physicians if they are taking, or plan to take serotonergic medications (see PRECAUTIONS ; Drug Interactions ).

Adrenal Insufficiency Inform patients that Percocet could cause adrenal insufficiency, a potentially life threatening condition. Adrenal insufficiency may present with non-specific symptoms and signs such as nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure. Advise patients to seek medical attention if they experience a constellation of these symptoms (see WARNINGS ).

Neonatal Opioid Withdrawal Syndrome Inform patients that prolonged use of Percocet during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated (see WARNINGS. PRECAUTIONS; Pregnancy )

Embryo-Fetal Toxicity Inform female patients of reproductive potential that Percocet can cause fetal harm and to inform the prescriber of a known or suspected pregnancy (see PRECAUTIONS; Pregnancy ).

Lactation Advise nursing mothers to monitor infants for increased sleepiness (more than usual), breathing difficulties, or limpness. Instruct nursing mothers to seek immediate medical care if they notice these signs (see PRECAUTIONS; Nursing Mothers ).

Disposal of Unused Percocet Advise patients to dispose of unused tablets by flushing down the toilet.

Laboratory Tests

Although oxycodone may cross-react with some drug urine tests, no available studies were found which determined the duration of detectability of oxycodone in urine drug screens. However, based on pharmacokinetic data, the approximate duration of detectability for a single dose of oxycodone is roughly estimated to be one to two days following drug exposure.

Urine testing for opiates may be performed to determine illicit drug use and for medical reasons such as evaluation of patients with altered states of consciousness or monitoring efficacy of drug rehabilitation efforts. The preliminary identification of opiates in urine involves the use of an immunoassay screening and thin-layer chromatography (TLC). Gas chromatography/mass spectrometry (GC/MS) may be utilized as a third-stage identification step in the medical investigational sequence for opiate testing after immunoassay and TLC. The identities of 6-keto opiates (e. g. oxycodone) can further be differentiated by the analysis of their methoxime-trimethylsilyl (MO-TMS) derivative.

Drug Interactions

CYP3A4 Inhibitor The concomitant use of Percocet and CYP3A4 inhibitors, such as macrolide antibiotics (e. g. erythromycin), azole-antifungal agents (e. g. ketoconazole), and protease inhibitors (e. g. ritonavir), can increase the plasma concentration of Percocet, resulting in increased or prolonged opioid effects. These effects could be more pronounced with concomitant use of Percocet and CYP3A4 inhibitors, particularly when an inhibitor is added after a stable dose of Percocet is achieved (see WARNINGS ).

After stopping a CYP3A4 inhibitor, as the effects of the inhibitor decline, the Percocet plasma concentration will decrease (see CLINICAL PHARMACOLOGY ), resulting in decreased opioid efficacy or a withdrawal syndrome in patients who had developed physical dependence to Percocet.

If concomitant use is necessary, consider dosage reduction of Percocet until stable drug effects are achieved. Monitor patients for respiratory depression and sedation at frequent intervals. If a CYP3A4 inhibitor is discontinued, consider increasing the Percocet dosage until stable drug effects are achieved. Monitor for signs of opioid withdrawal.

Inducer The concomitant use of Percocet and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of Percocet (see CLINICAL PHARMACOLOGY ), resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to Percocet (see WARNINGS ).

After stopping a CYP3A4 inducer, as the effects of the inducer decline, the Percocet plasma concentration will increase (see CLINICAL PHARMACOLOGY ), which could increase or prolong both the therapeutic effects and adverse reactions, and may cause serious respiratory depression.

If concomitant use is necessary, consider increasing the Percocet dosage until stable drug effects are achieved. Monitor for signs of opioid withdrawal. If a CYP3A4 inducer is discontinued, consider Percocet dosage reduction and monitor for signs of respiratory depression.

Central Nervous System Depressants

Due to additive pharmacologic effect, the concomitant use of CNS depressants such as alcohol, benzodiazepines and other sedative hypnotics, anxiolytics, and tranquilizers, muscle relaxants, general anesthetics, antipsychotics, and other opioids, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death.

Consider dose reduction of one or both drugs. Monitor patients for signs of respiratory depression, sedation, and hypotension (see WARNINGS ).

The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that effect the serotonin neurotransmitter system (e. g. mirtazapine, trazodone, tramadol), and monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue), has resulted in serotonin syndrome. (see PRECAUTIONS ; Information for Patients ).

If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Discontinue Percocet if serotonin syndrome is suspected.

Drug/Drug Interactions with Oxycodone

Opioid analgesics may enhance the neuromuscular-blocking action of skeletal muscle relaxants and produce an increase in the degree of respiratory depression.

Patients receiving CNS depressants such as other opioid analgesics, general anesthetics, phenothiazines, other tranquilizers, centrally-acting anti-emetics, sedative-hypnotics or other CNS depressants (including alcohol) concomitantly with Percocet tablets may exhibit an additive CNS depression. When such combined therapy is contemplated, the dose of one or both agents should be reduced. The concurrent use of anticholinergics with opioids may produce paralytic ileus.

Agonist/antagonist analgesics (i. e. pentazocine, nalbuphine, naltrexone, and butorphanol) should be administered with caution to a patient who has received or is receiving a pure opioid agonist such as oxycodone. These agonist/antagonist analgesics may reduce the analgesic effect of oxycodone or may precipitate withdrawal symptoms.

Drug/Drug Interactions with Acetaminophen

Alcohol, ethyl: Hepatotoxicity has occurred in chronic alcoholics following various dose levels (moderate to excessive) of acetaminophen.

Anticholinergics: The onset of acetaminophen effect may be delayed or decreased slightly, but the ultimate pharmacological effect is not significantly affected by anticholinergics.

Oral Contraceptives: Increase in glucuronidation resulting in increased plasma clearance and a decreased half-life of acetaminophen.

Charcoal (activated): Reduces acetaminophen absorption when administered as soon as possible after overdose.

Beta Blockers (Propranolol): Propranolol appears to inhibit the enzyme systems responsible for the glucuronidation and oxidation of acetaminophen. Therefore, the pharmacologic effects of acetaminophen may be increased.

Loop diuretics: The effects of the loop diuretic may be decreased because acetaminophen may decrease renal prostaglandin excretion and decrease plasma renin activity.

Lamotrigine: Serum lamotrigine concentrations may be reduced, producing a decrease in therapeutic effects.

Probenecid: Probenecid may increase the therapeutic effectiveness of acetaminophen slightly.

Zidovudine: The pharmacologic effects of zidovudine may be decreased because of enhanced non-hepatic or renal clearance of zidovudine.

Drug/Laboratory Test Interactions

Depending on the sensitivity/specificity and the test methodology, the individual components of Percocet (Oxycodone and Acetaminophen Tablets, USP) may cross-react with assays used in the preliminary detection of cocaine (primary urinary metabolite, benzoylecgonine) or marijuana (cannabinoids) in human urine. A more specific alternate chemical method must be used in order to obtain a confirmed analytical result. The preferred confirmatory method is gas chromatography/mass spectrometry (GC/MS). Moreover, clinical considerations and professional judgment should be applied to any drug-of-abuse test result, particularly when preliminary positive results are used.

Acetaminophen may interfere with home blood glucose measurement systems; decreases of >20% in mean glucose values may be noted. This effect appears to be drug, concentration and system dependent.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Animal studies to evaluate the carcinogenic potential of oxycodone and acetaminophen have not been performed.

The combination of oxycodone and acetaminophen has not been evaluated for mutagenicity. Oxycodone alone was negative in a bacterial reverse mutation assay (Ames), an in vitro chromosome aberration assay with human lymphocytes without metabolic activation and an in vivo mouse micronucleus assay. Oxycodone was clastogenic in the human lymphocyte chromosomal assay in the presence of metabolic activation and in the mouse lymphoma assay with or without metabolic activation.

Chronic use of opioids may cause reduced fertility in females and males of reproductive potential. It is not known whether these effects on fertility are reversible (see ADVERSE REACTIONS ).

Pregnancy

Pregnancy Category C

Animal reproductive studies have not been conducted with Percocet. It is also not known whether Percocet can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Percocet should not be given to a pregnant woman unless in the judgment of the physician, the potential benefits outweigh the possible hazards.

Fetal/Neonatal Adverse Reactions Prolonged use of opioid analgesics during pregnancy for medical or nonmedical purposes can result in physical dependence in the neonate and neonatal opioid withdrawal syndrome shortly after birth.

Neonatal opioid withdrawal syndrome presents as irritability, hyperactivity and abnormal sleep pattern, high pitched cry, tremor, vomiting, diarrhea and failure to gain weight. The onset, duration, and severity of neonatal opioid withdrawal syndrome vary based on the specific opioid used, duration of use, timing and amount of last maternal use, and rate of elimination of the drug by the newborn. Observe newborns for symptoms of neonatal opioid withdrawal syndrome and manage accordingly (see WARNINGS ).

Labor and Delivery

Opioids cross the placenta and may produce respiratory depression and psycho-physiologic effects in neonates. An opioid antagonist, such as naloxone, must be available for reversal of opioid-induced respiratory depression in the neonate. Percocet is not recommended for use in pregnant women during or immediately prior to labor, when other analgesic techniques are more appropriate. Opioid analgesics, including Percocet, can prolong labor through actions which temporarily reduce the strength, duration, and frequency of uterine contractions. However, this effect is not consistent and may be offset by an increased rate of cervical dilation, which tends to shorten labor. Monitor neonates exposed to opioid analgesics during labor for signs of excess sedation and respiratory depression.

Nursing Mothers

The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Percocet and any potential adverse effects on the breastfed infant from Percocet or from the underlying maternal condition.

Infants exposed to Percocet through breast milk should be monitored for excess sedation and respiratory depression. Withdrawal symptoms can occur in breastfed infants when maternal administration of an opioid analgesic is stopped, or when breast-feeding is stopped.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Geriatric Use

Elderly patients (aged 65 years or older) may have increased sensitivity to Percocet. In general, use caution when selecting a dosage for an elderly patient, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.

Respiratory depression is the chief risk for elderly patients treated with opioids, and has occurred after large initial doses were administered to patients who were not opioid-tolerant or when opioids were co-administered with other agents that depress respiration. Titrate the dosage of Percocet slowly in geriatric patients (see WARNINGS ).

Hepatic Impairment

In a pharmacokinetic study of oxycodone in patients with end-stage liver disease, oxycodone plasma clearance decreased and the elimination half-life increased. Care should be exercised when oxycodone is used in patients with hepatic impairment.

Renal Impairment

In a study of patients with end stage renal impairment, mean elimination half-life was prolonged in uremic patients due to increased volume of distribution and reduced clearance. Oxycodone should be used with caution in patients with renal impairment.

Adverse Reactions

Serious adverse reactions that may be associated with Percocet tablet use include adrenal insufficiency, apnea, circulatory depression, hypotension, respiratory arrest, respiratory depression, serotonin syndrome, and shock (see OVERDOSAGE ).

Chronic use of opioids may influence the hypothalamic-pituitary-gonadal axis, leading to androgen deficiency that may manifest as symptoms of hypogonadism, such as impotence, erectile dysfunction, or amenorrhea. The causal role of opioids in the syndrome of hypogonadism is unknown because the various medical, physical, lifestyle, and psychological stressors that may influence gonadal hormone levels have not been adequately controlled for in studies conducted to date. Patients presenting with symptoms of androgen deficiency should undergo laboratory evaluation.

The most frequently observed non-serious adverse reactions include dizziness, drowsiness or sedation, lightheadedness, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in nonambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down. Other adverse reactions include, constipation, dysphoria, euphoria, and pruritus.

Hypersensitivity reactions may include: Erythematous skin reactions, skin eruptions, urticarial. Hematologic reactions may include: Hemolytic anemia, neutropenia, thrombocytopenia, pancytopenia. Rare cases of agranulocytosis has likewise been associated with acetaminophen use. In high doses, the most serious adverse effect is a dose-dependent, potentially fatal hepatic necrosis. Renal tubular necrosis and hypoglycemic coma also may occur.

Other adverse reactions obtained from postmarketing experiences with Percocet tablets are listed by organ system and in decreasing order of severity and/or frequency as follows:

Body as a Whole

Anaphylactoid reaction, allergic reaction, malaise, asthenia, fatigue, chest pain, fever, hypothermia, thirst, headache, increased sweating, accidental overdose, non-accidental overdose

Cardiovascular

Hypotension, hypertension, tachycardia, orthostatic hypotension, bradycardia, palpitations, dysrhythmias

Central and Peripheral Nervous System

Stupor, tremor, paraesthesia, hypoaesthesia, lethargy, seizures, anxiety, mental impairment, agitation, cerebral edema, confusion, dizziness

Fluid and Electrolyte

Dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis

Gastrointestinal

Dyspepsia, taste disturbances, abdominal pain, abdominal distention, sweating increased, diarrhea, dry mouth, flatulence, gastro-intestinal disorder, nausea, vomiting, pancreatitis, intestinal obstruction, ileus

Hepatic

Transient elevations of hepatic enzymes, increase in bilirubin, hepatitis, hepatic failure, jaundice, hepatotoxicity, hepatic disorder

Hearing and Vestibular

Hearing loss, tinnitus

Hematologic

Hypersensitivity

Acute anaphylaxis, angioedema, asthma, bronchospasm, laryngeal edema, urticaria, anaphylactoid reaction

Metabolic and Nutritional

Hypoglycemia, hyperglycemia, acidosis, alkalosis

Musculoskeletal

Ocular

Miosis, visual disturbances, red eye

Psychiatric

Drug dependence, drug abuse, insomnia, confusion, anxiety, agitation, depressed level of consciousness, nervousness, hallucination, somnolence, depression, suicide

Respiratory System

Bronchospasm, dyspnea, hyperpnea, pulmonary edema, tachypnea, aspiration, hypoventilation, laryngeal edema

Skin and Appendages

Erythema, urticaria, rash, flushing

Urogenital

Interstitial nephritis, papillary necrosis, proteinuria, renal insufficiency and failure, urinary retention

Drug Abuse and Dependence

Controlled Substance

Percocet contains oxycodone, a Schedule II controlled substance.

Abuse

Percocet contains oxycodone, a substance with a high potential for abuse similar to other opioids including morphine and other opioids in analgesia. Percocet can be abused and is subject to misuse, addiction, and criminal diversion (see WARNINGS ).

All patients treated with opioids require careful monitoring for signs of abuse and addiction, since use of opioid analgesic products carries the risk of addiction even under appropriate medical use.

Prescription drug abuse is the intentional non-therapeutic use of a prescription drug, even once, for its rewarding psychological or physiological effects.

Drug addiction is a cluster of behavioral, cognitive, and physiological phenomena that develop after repeated substance use and includes: a strong desire to take the drug, difficulties in controlling its use, persisting in its use despite harmful consequences, a higher priority given to drug use than to other activities and obligations, increased tolerance, and sometimes a physical withdrawal.

“Drug-seeking” behavior is very common in persons with substance use disorders. Drug-seeking tactics include emergency calls or visits near the end of office hours, refusal to undergo appropriate examination, testing, or referral, repeated “loss” of prescriptions, tampering with prescriptions and reluctance to provide prior medical records or contact information for other treating health care provider(s). “Doctor shopping” (visiting multiple prescribers) to obtain additional prescriptions is common among drug abusers and people suffering from untreated addiction. Preoccupation with achieving adequate pain relief can be appropriate behavior in a patient with poor pain control.

Abuse and addiction are separate and distinct from physical dependence and tolerance. Health care providers should be aware that addiction may not be accompanied by concurrent tolerance and symptoms of physical dependence in all addicts. In addition, abuse of opioids can occur in the absence of true addiction.

Percocet like other opioids, can be diverted for non-medical use into illicit channels of distribution. Careful record-keeping of prescribing information, including quantity, frequency, and renewal requests, as required by state and federal law, is strongly advised.

Proper assessment of the patient, proper prescribing practices, periodic re-evaluation of therapy, and proper dispensing and storage are appropriate measures that help to limit abuse of opioid drugs.

Risks Specific to Abuse of Percocet

Percocet are for oral use only. Abuse of Percocet pose a risk of overdose and death.

Dependence

Both tolerance and physical dependence can develop during chronic opioid therapy. Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia (in the absence of disease progression or other external factors). Tolerance may occur to both the desired and undesired effects of drugs, and may develop at different rates for different effects.

Physical dependence results in withdrawal symptoms after abrupt discontinuation or a significant dosage reduction of a drug. Withdrawal also may be precipitated through the administration of drugs with opioid antagonist activity (e. g. naloxone, nalmefene), mixed agonist/antagonist analgesics (pentazocine, butorphanol, nalbuphine), or partial agonists (buprenorphine). Physical dependence may not occur to a clinically significant degree until after several days to weeks of continued opioid usage.

Percocet should not be abruptly discontinued (see DOSAGE AND ADMINISTRATION ). If Percocet are abruptly discontinued in a physically dependent patient, a withdrawal syndrome may occur. Some or all of the following can characterize this syndrome: restlessness, lacrimation, rhinorrhea, yawning, perspiration, chills, myalgia, and mydriasis. Other signs and symptoms also may develop, including: irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate.

Infants born to mothers physically dependent on opioids will also be physically dependent and may exhibit respiratory difficulties and withdrawal signs (see PRECAUTIONS; Pregnancy ).

Interactions with Alcohol and Drugs of Abuse

Oxycodone may be expected to have additive effects when used in conjunction with alcohol, other opioids, or illicit drugs that cause central nervous system depression.

Overdosage

Following an acute overdosage, toxicity may result from the oxycodone or the acetaminophen.

Acute overdose with Percocet can be manifested by respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and, in some cases, pulmonary edema, bradycardia, hypotension, partial or complete airway obstruction, atypical snoring, and death. Marked mydriasis rather than miosis may be seen with hypoxia in overdose situations.

In acetaminophen overdosage: dose-dependent potentially fatal hepatic necrosis is the most serious adverse effect. Renal tubular necrosis, hypoglycemic coma, and coagulation defects may also occur.

Early symptoms following a potentially hepatotoxic overdose may include: nausea, vomiting, diaphoresis, and general malaise. Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion.

Treatment of Overdose

Oxycodone In case of overdose, priorities are the reestablishment of a patent and protected airway and institution of assisted or controlled ventilation, if needed. Employ other supportive measures (including oxygen and vasopressors) in the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require advanced life-support techniques.

The opioid antagonists, naloxone or nalmefene, are specific antidotes to respiratory depression resulting from opioid overdose. For clinically significant respiratory or circulatory depression secondary to Percocet overdose, administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant respiratory or circulatory depression secondary to Percocet overdose.

Because the duration of opioid reversal is expected to be less than the duration of action of oxycodone in Percocet, carefully monitor the patient until spontaneous respiration is reliably re-established. If the response to an opioid antagonist is suboptimal or only brief in nature, administer additional antagonist as directed by the product’s prescribing information.

In an individual physically dependent on opioids, administration of the recommended usual dosage of the antagonist will precipitate an acute withdrawal syndrome. The severity of the withdrawal symptoms experienced will depend on the degree of physical dependence and the dose of the antagonist administered. If a decision is made to treat serious respiratory depression in the physically dependent patient, administration of the antagonist should be begun with care and by titration with smaller than usual doses of the antagonist.

Acetaminophen Gastric decontamination with activated charcoal should be administered just prior to N-acetylcysteine (NAC) to decrease systemic absorption if acetaminophen ingestion is known or suspected to have occurred within a few hours of presentation. Serum acetaminophen levels should be obtained immediately if the patient presents 4 hours or more after ingestion to assess potential risk of hepatotoxicity; acetaminophen levels drawn less than 4 hours post-ingestion may be misleading. To obtain the best possible outcome, NAC should be administered as soon as possible where impending or evolving liver injury is suspected. Intravenous NAC may be administered when circumstances preclude oral administration.

Vigorous supportive therapy is required in severe intoxication. Procedures to limit the continuing absorption of the drug must be readily performed since the hepatic injury is dose dependent and occurs early in the course of intoxication.

Percocet Dosage and Administration

Important Dosage and Administration Instructions

Initiate the dosing regimen for each patient individually, taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse (see WARNINGS ).

Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy and following dosage increases with Percocet and adjust the dosage accordingly (see WARNINGS ).

Initial Dosage

Initiating Treatment with Percocet

Initiate treatment with Percocet tablets 2.5 mg/325 mg adult dosage, with one or 2 tablets every 6 hours as needed for pain.

The total daily dose of acetaminophen should not exceed 4 grams.

Initiate treatment with Percocet tablets 5 mg/325 mg; Percocet tablets 7.5 mg/325 mg; Percocet tablets 10 mg/325 mg, adult dosage, with one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.

Titration and Maintenance of Therapy

Individually titrate Percocet to a dose that provides adequate analgesia and minimizes adverse reactions. Continually reevaluate patients receiving Percocet to assess the maintenance of pain control and the relative incidence of adverse reactions, as well as monitoring for the development of addiction, abuse, or misuse (see WARNINGS ). Frequent communication is important among the prescriber, other members of the healthcare team, the patient, and the caregiver/family during periods of changing analgesic requirements, including initial titration.

If the level of pain increases after dosage stabilization, attempt to identify the source of increased pain before increasing the Percocet dosage. If unacceptable opioid-related adverse reactions are observed, consider reducing the dosage. Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions.

Discontinuation of Percocet tablets

When a patient who has been taking Percocet regularly and may be physically dependent no longer requires therapy with Percocet, use a gradual downward titration of the dosage to prevent signs and symptoms of withdrawal. Do not stop Percocet abruptly (see WARNINGS. DRUG ABUSE AND DEPENDENCE ).

How is Percocet Supplied

Percocet (Oxycodone and Acetaminophen Tablets, USP) is supplied as follows:

2.5 mg/325 mg Pink, oval, tablet, debossed with “Percocet” on one side and “2.5” on the other. Bottles of 100 NDC 63481-627-70

5 mg/325 mg Blue, round, tablet, debossed with “Percocet” and “5” on one side and bisect on the other. Bottles of 100 NDC 63481-623-70 Bottles of 500 NDC 63481-623-85

7.5 mg/325 mg Peach, oval-shaped, tablet, debossed with “Percocet” on one side and “7.5/325” on the other. Bottles of 100 NDC 63481-628-70

10 mg/325 mg Yellow, capsule-shaped, tablet, debossed with “Percocet” on one side and “10/325” on the other. Bottles of 100 NDC 63481-629-70

Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature].

Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).

DEA Order Form Required.

Manufactured for: Endo Pharmaceuticals Inc. Malvern, PA 19355

Percocet ® is a registered trademark of Endo Pharmaceuticals Inc.

© 2016 Endo Pharmaceuticals Inc. All rights reserved.

8183395 R6 March 2016

Medication Guide Percocet ® (ˈpər-kō-ˌset) Tablets, CII

A strong prescription pain medicine that contains an opioid (narcotic) that is used to manage moderate to moderately severe pain severe enough to require an opioid analgesic, when other pain treatments such as non-opioid pain medicines do not treat your pain well enough or you cannot tolerate them.

An opioid pain medicine that can put you at risk for overdose and death. Even if you take your dose correctly as prescribed you are at risk for opioid addiction, abuse, and misuse that can lead to death.

Important information about Percocet tablets

Get emergency help right away if you take too much Percocet (overdose). When you first start taking Percocet, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur.

Never give anyone else your Percocet. They could die from taking it. Store Percocet away from children and in a safe place to prevent stealing or abuse. Selling or giving away Percocet is against the law.

Do not take Percocet if you have:

severe asthma, trouble breathing, or other lung problems

a bowel blockage or have narrowing of the stomach or intestines

known hypersensitivity to oxycodone, acetaminophen, or any other component of this product

hypercarbia

Before taking Percocet tell your healthcare provider if you have a history of:

head injury, seizures

problems urinating

abuse of street or prescription drugs, alcohol addiction, or mental health problems.

liver, kidney, thyroid problems

pancreas or gallbladder problems

Tell your healthcare provider if you are:

pregnant or planning to become pregnant. Prolonged use of Percocet during pregnancy can cause withdrawal symptoms in your newborn baby that could be life-threatening if not recognized and treated.

breastfeeding. Percocet passes into breast milk and may harm your baby.

taking prescription or over-the-counter medicines, vitamins, or herbal supplements. Taking Percocet with certain other medicines can cause serious side effects that could lead to death.

When taking Percocet:

Do not change your dose. Take Percocet exactly as prescribed by your healthcare provider.

Take your prescribed dose every 6 hours at the same time every day. Do not take more than your prescribed dose. If you miss a dose, take your next dose at your usual time.

Call your healthcare provider if the dose you are taking does not control your pain.

If you have been taking Percocet regularly, do not stop taking Percocet without talking to your healthcare provider.

After you stop taking Percocet, the unused tablets should be destroyed by flushing down the toilet.

While taking Percocet DO NOT:

Drive or operate heavy machinery, until you know how Percocet affects you. Percocet can make you sleepy, dizzy, or lightheaded.

Drink alcohol or use prescription or over-the-counter medicines that contain alcohol. Using products containing alcohol during treatment with Percocet may cause you to overdose and die.

The possible side effects of Percocet.

constipation, nausea, sleepiness, vomiting, tiredness, headache, dizziness, abdominal pain. Call your healthcare provider if you have any of these symptoms and they are severe.

Get emergency medical help if you have:

trouble breathing, shortness of breath, fast heartbeat, chest pain, swelling of your face, tongue, or throat, extreme drowsiness, light-headedness when changing positions, feeling faint, agitation, high body temperature, trouble walking, stiff muscles, or mental changes such as confusion.

These are not all the possible side effects of Percocet. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. For more information go to dailymed. nlm. nih. gov

Manufactured for: Endo Pharmaceuticals Inc. Malvern, PA 19355. call 1-800-462-3636

This Medication Guide has been approved by the U. S. Food and Drug Administration.

Issued: March/2016 8183820 R0

Package Label - Principal Display Panel – 2.5 mg/325 mg 100 Count Bottle

Package Label - Principal Display Panel - 5 mg/325 mg 100 Count Bottle

Package Label - Principal Display Panel - 7.5 mg/325 mg 100 Count Bottle

Package Label - Principal Display Panel - 10 mg/325 mg 100 Count Bottle

Braxton Family Values - Tamar Braxton - We Tv, Tiamar

Tamar Braxton

About Tamar Braxton

The youngest and most outspoken of the Braxton’s six children, Tamar started singing as a toddler. Evelyn recognized her daughter’s talents when one day Tamar sang “Can you please get me some toilet paper!” Tamar claims she knew as early as three years old that she wanted to be center stage.

When the sisters formed The Braxtons, Tamar’s high soprano voice was in sharp contrast to Toni’s husky contralto. Then after The Braxtons broke up, Tamar and her sisters sang back-up for Toni and can be seen in the video “Seven Whole Days.” In 1996 (without Toni), the sisters released an album for Atlantic called “So Many Ways.” A few years later, Tamar explored her gospel side on T. D. Jakes’ Love Songs album. She later met Christopher “Tricky” Stewart, a rapper/producer based in Atlanta, Georgia, who recorded her solo debut album, Ridiculous, which got its name due to the many different musical styles on the album. Ridiculous was retooled and released by Dreamworks as Tamar in 2000.

Also in 2000, Tamar performed in Toni Braxton’s “He Wasn’t Man Enough” video and sang on the soundtrack for the feature “Kingdom Come”, in which Toni appears as Juanita Slocumb. Tamar also sang background on Toni’s albums The Heat, More Than A Woman, Libra and Pulse. In 2004, Tamar was briefly signed to Tommy Mattola’s Casablanca Records and released the promotional single “I’m Leaving”.

While writing and actively singing on Toni’s albums, Tamar began working closely with “super producer,” executive and best friend to Toni, Vincent Herbert. The two became very close and wed in the fall of 2008. While still being a well sought after background singer, Tamar signed a new deal with her husband’s record label and is currently working on her long awaited album. Along with working on her own music, Tamar also was a featured background vocalist in Lady Gaga’s “Born This Way.” Tamar is also an actress who has worked with Tyler Perry on the play “Madea Goes to Jail” as well as doing a voice-over for Will Smith’s webisodes, “The Fresh Prince.” Although Tamar has always had a close relationship to Toni, who used to dress her up and take her everywhere she went, Tamar is determined not to live in her big sister’s shadow.

Tamar has simple advice for keeping a man: bacon maple donuts. Tamar; “… any man you want – black, yellow, purple, Puerto Rican, Asian. Right there.”

More Cast

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Ciprodex (Otic Suspension) Ear Drops, Cipronex

Ciprodex

Ciprodex ear drops contain ciprofloxacin and dexamethasone. Ciprofloxacin is an antibiotic that treats infections caused by bacteria.

Dexamethasone is a steroid. It reduces the actions of chemicals in the body that cause inflammation.

Ciprodex is used to treat infections inside the ear (also called otitis media ), and infections of the ear canal (also called otitis externa).

Ciprodex may also be used for purposes not listed in this medication guide.

Important information

You should not use Ciprodex ear drops if you have a viral infection affecting your ear canal, including herpes or chickenpox.

Do not use this medication in the eyes or take it by mouth. Ciprodex is intended for use in the ears only. Do not touch the dropper opening to any surface, including the ears or hands. The dropper opening is sterile. If it becomes contaminated, it could cause another infection in the ear.

Notify your doctor if the condition does not improve or appears to worsen.

Before taking this medicine

You should not use Ciprodex ear drops if you are allergic to ciprofloxacin or dexamethasone, or if you have:

a viral infection affecting your ear canal, including herpes or chickenpox; or

if you are allergic to any antibiotic similar to ciprofloxacin (Cipro), such as gatifloxacin (Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), or ofloxacin (Floxin).

To make sure Ciprodex is safe for you, tell your doctor if you have:

severe ear pain; or

FDA pregnancy category C. It is not known whether Ciprodex will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether ciprofloxacin and dexamethasone otic passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Ciprodex should not be used on a child younger than 6 months old.

How should I use Ciprodex?

Use Ciprodex exactly as directed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not take by mouth. Ciprodex is for use only in the ears.

Shake the medicine well just before each use.

You may warm the medicine before use by holding the bottle in your hand for 1 or 2 minutes. Using cold ear drops can cause dizziness, especially in a child who has ear tubes in place.

To use the Ciprodex ear drops:

Lie down or tilt your head with your ear facing upward. Open the ear canal by gently pulling your ear back, or pulling downward on the earlobe when giving this medicine to a child.

Hold the dropper upside down over your ear and drop the correct number of drops into the ear.

Stay lying down or with your head tilted for 60 seconds. You may use a small piece of cotton to plug the ear and keep the medicine from draining out.

Do not touch the Ciprodex dropper tip or place it directly in your ear. It may become contaminated. Wipe the tip with a clean tissue but do not wash with water or soap.

Use Ciprodex for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have new symptoms.

Store Ciprodex ear drops at room temperature away from moisture, heat, and light. Throw away any unused medicine after your treatment is finished.

Ciprodex dosing information

Usual Adult Dose of Ciprodex for Otitis Externa:

4 drops in the affected ear twice daily for 7 days

Usual Pediatric Dose for Otitis Media:

>=6 months: 4 drops in the affected ear twice daily for 7 days

Usual Pediatric Dose for Otitis Externa:

>=6 months: 4 drops in the affected ear twice daily for 7 days

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of this medicine is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using Ciprodex?

Avoid getting water in your ears while bathing or showering. Avoid swimming while you are treating an ear infection.

Avoid getting the medicine in your eyes.

Do not use other ear medications unless your doctor tells you to.

Ciprodex side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Ciprodex . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Ciprodex and call your doctor at once if you have:

the first sign of any skin rash, no matter how mild;

drainage from your ears; or

severe burning or other irritation after using the ear drops.

Common Ciprodex side effects may include:

ear itching or pain, ear discomfort or fullness;

unusual taste in your mouth;

a buildup of debris in the ear canal.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Ciprodex?

It is not likely that other drugs you take orally or inject will have an effect on Ciprodex used in the ears. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

More about Ciprodex (ciprofloxacin / dexamethasone otic)

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about Ciprodex.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Ciprodex only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 2.01. Revision Date: 2014-10-29, 1:59:13 PM.

The 19th Annual Independent Games Festival, Liporest

2011 - Multiple award winner Minecraft has now sold almost 2 million copies and spawned a worldwide cult around its charming open-world game design.

2010 - Playdead's stark monochromatic platform title Limbo is a smash hit on Xbox Live Arcade, following its summer 2010 release, picking up a 2011 Game Developers Choice Award for Best Visual Arts.

2010 - The team behind 2009 Student Showcase finalist Tag: The Power of Paint are hired by Valve to implement new paint gun mechanics into Portal 2.

2009 - The Behemoth's follow-up to Alien Hominid, the IGF-winning Castle Crashers, tops XBLA charts to critical acclaim.

2009 - IGF multi-award winner World Of Goo launches as one of the best-selling, best-reviewed WiiWare titles of all time, alongside a popular PC version.

2009 - Petri Purho's Crayon Physics Deluxe spawns an iPhone version courtesy of Hudson, plus a popular PC downloadable version.

2008 - The team behind IGF Student Showcase finalist Narbacular Drop is hired by Valve. The game is reworked into Portal and goes on to win the coveted Game Developer's Choice "Best Game" award for 2008, as well as numerous game of the year accolades.

2008 - Design Innovation winner Braid debuts on Xbox Live Arcade to significant success. 2008 - Excellence in Audio winner Audiosurf launches on Valve's Steam distribution service and goes on to become the highest selling game of February, outselling even Valve's own Orange box (including Team Fortress 2 and Game Developer's Choice "Best Game" winner Portal.)

2007 - Design Innovation winner Everyday Shooter is signed by Sony for distribution on the PlayStation 3's PlayStation Network, after Sony's John Hight plays the game at the IGF Pavilion during GDC 2007 - Everyday Shooter's Jon Mak also appears at the inaugural Independent Games Summit.

2006 - Grand prize winner Darwinia gets both digital distribution via Valve's Steam system and U. S. retail distribution from new indie label Cinemaware Marquee.

2005 - Multi award-winner Alien Hominid receives publishing deals in the U. S. (via O3 Publishing) and Europe(via Zoo Digital), much critical acclaim, and even spawns a mobile version.

2005 - Fan favorite N wins the audience award, and, as N+, releases as a hit XBLA title, as well as notable Nintendo DS and Sony PSP versions.

2004 - Innovative casual strategy game Oasis wins the web/downloadable grand prize, going on to launch on major online portals the following year.

2003 - Super X Studios' Wild Earth, a photographic game based around a worldwide safari, takes multiple prizes and subsequently becomes a motion simulator ride and eventually (in adapted form) a Wii title.

2000 - Tread Marks, created by the late Seumas McNally, which the IGF's grand prize is now named after, wins 3 major awards.

1999 - Vicarious Visions, now a major handheld / console developer, honored for Terminus.

Anacin - Pain Relief, Doxyfene

Anacin is a pain reliever intended for the temporary relief of minor aches and pains. Anacin is a combination salicylate and stimulant. It works by blocking several different chemical processes within the body that cause pain, inflammation, and fever. It also reduces the tendency for blood to clot.

Availability: In Stock (17 packs)

Anacin is used for treating pain including, headache, muscle aches, sprains, tooth extraction and toothache, menstrual cramps, arthritis and rheumatism, and pain and fever of the common cold. It may also be used for other conditions as determined by your doctor.

Use Anacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Anacin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Taking it with food may not decrease the risk of stomach or bowel problems (eg, bleeding, ulcers) that may occur while taking Anacin.

Take Anacin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Anacin.

Use Anacin exactly as directed on the package, unless instructed differently by your doctor. If you are taking Anacin without a prescription, follow any warnings and precautions on the label.

If you miss a dose of Anacin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Anacin.

Store Anacin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Anacin out of the reach of children and away from pets.

Anacin may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Anacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate). This includes any medicines that contain caffeine.

Anacin has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Talk to your doctor before you take Anacin or other pain relievers/fever reducers if you drink more than 3 drinks with alcohol per day. Serious stomach ulcers or bleeding can occur with the use of Anacin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Anacin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Taking more than the recommended dose or taking Anacin regularly may be habit-forming.

Anacin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

Aspirin has been linked to a serious illness called Reye syndrome. Do not give Anacin to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.

Diabetes patients - Anacin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If Anacin has a strong vinegar-like smell upon opening, do not use. It means the medicine is breaking down. Throw the bottle away safely and out of the reach of children; contact your pharmacist and replace.

Tell your doctor or dentist that you take Anacin before you receive any medical or dental care, emergency care, or surgery.

Do not take Anacin for at least 7 days after any surgery unless directed by your health care provider.

Do not take Anacin for more than 10 days for pain or for more than 3 days for fever unless directed to do so by your health care provider.

Different brands of Anacin may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.

Do NOT use Anacin if:

you are allergic to any ingredient in Anacin

you are a child or teenager with influenza (flu) or chickenpox

you have bleeding problems such as hemophilia, von Willebrand disease, or low blood platelets, or you have active severe bleeding

you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness) to aspirin, tartrazine, or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)

you are taking anticoagulants (eg, heparin, warfarin) or methotrexate

Before using Anacin:

Some medical conditions may interact with Anacin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have alcoholism or if you consume 3 or more alcohol-containing drinks every day

if you have asthma, bleeding or clotting problems, growths in the nose (nasal polyps), kidney or liver problems, stomach or intestinal problems (eg, ulcer, inflammation), heart problems, heartburn, upset stomach, stomach pain, hives, influenza (flu) or chickenpox, or vitamin K deficiency

if you have anxiety, trouble sleeping, or heart problems

if you are a child with a stroke, a weakened blood vessel (cerebral aneurysm) or bleeding in the brain, rheumatic disease (eg, rheumatoid arthritis), or Kawasaki syndrome (a rare inflammation causing heart problems in children)

Some MEDICINES MAY INTERACT with Anacin. Tell your health care provider if you are taking any other medicines.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Anacin while you are pregnant. Anacin is not recommended during the last 3 months (third trimester) of pregnancy because it may cause harm to the fetus. Anacin is found in breast milk. If you are or will be breast-feeding while you use Anacin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects. Anacin's side effects may include dizziness, heartburn, irritability, nausea, nervousness, rashes, hives, bloody stools, drowsiness, hearing loss, ringing in the ears, and trouble sleeping.

Check with your doctor if any of the listed above most COMMON side effects persist or become bothersome.

Seek medical attention right away if any of these SEVERE side effects occur: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; confusion; diarrhea; drowsiness; hearing loss; ringing in the ears; severe or persistent dizziness; severe or persistent stomach pain or heartburn; shakiness; trouble sleeping; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Anova (Analysis Of Variance) - Statistics Definition, Aova

What Is ANOVA?

By Courtney Taylor. Statistics Expert

Courtney K. Taylor, Ph. D. is an associate professor of mathematics at Anderson University in Anderson, Indiana. He teaches a wide variety of courses throughout mathematics, including those involving statistics.

Updated October 14, 2015.

Many times when we study a group, we are really comparing two populations. Depending upon the parameter of this group we are interested in and the conditions we are dealing with, there are several techniques available. Statistical inference procedures that concern the comparison of two populations cannot usually be applied to three or more populations. To study more than two populations at once, we need different types of statistical tools.

Continue Reading Below

Analysis of variance. or ANOVA, is a technique from statistical interference that allows us to deal with several populations.

Comparison of Means

To see what problems arise and why we need ANOVA, we will consider an example. Suppose we are trying to determine if the mean weights of green, red, blue and orange M&M candies are different from each other. We will state the mean weights for each of these populations, ? 1 . ? 2 . ? 3 ? 4 and respectively. We may use the appropriate hypothesis test several times, and test C(4,2). or six different null hypotheses :

H 0 . ? 1 = ? 2 to check if the mean weight of the population of the red candies is different than the mean weight of the population of the blue candies.

H 0 . ? 2 = ? 3 to check if the mean weight of the population of the blue candies is different than the mean weight of the population of the green candies.

H 0 . ? 3 = ? 4 to check if the mean weight of the population of the green candies is different than the mean weight of the population of the orange candies.

H 0 . ? 4 = ? 1 to check if the mean weight of the population of the orange candies is different than the mean weight of the population of the red candies.

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H 0 . ? 1 = ? 3 to check if the mean weight of the population of the red candies is different than the mean weight of the population of the green candies.

H 0 . ? 2 = ? 4 to check if the mean weight of the population of the blue candies is different than the mean weight of the population of the orange candies.

There are many problems with this kind of analysis. We will have six p - values. Even though we may test each at a 95% level of confidence. our confidence in the overall process is less than this because probabilities multiply. 95 x .95 x .95 x .95 x .95 x .95 is approximately .74, or an 74% level of confidence. Thus the probability of a type I error has increased.

At a more fundamental level, we cannot compare these four parameters as a whole by comparing them two at a time. The means of the red and blue M&Ms may be significant, with the mean weight of red being relatively larger than the mean weight of the blue. However, when we consider the mean weights of all four kinds of candy, there may not be a significant difference.

Analysis of Variance

To deal with situations in which we need to make multiple comparisons we use ANOVA. This test allows us to consider the parameters of several populations at once, without getting into some of the problems that confront us by conducting hypothesis tests on two parameters at a time.

To conduct ANOVA with the M&M example above, we would test the null hypothesis H 0 :? 1 = ? 2 = ? 3 = ? 4 . This states that there is no difference between the mean weights of the red, blue and green M&Ms. The alternative hypothesis is that there is some difference between the mean weights of the red, blue, green and orange M&Ms. This hypothesis is really a combination of several statements H a :

The mean weight of the population of red candies is not equal to the mean weight of the population of blue candies, OR

The mean weight of the population of blue candies is not equal to the mean weight of the population of green candies, OR

The mean weight of the population of green candies is not equal to the mean weight of the population of orange candies, OR

The mean weight of the population of green candies is not equal to the mean weight of the population of red candies, OR

The mean weight of the population of blue candies is not equal to the mean weight of the population of orange candies, OR

The mean weight of the population of blue candies is not equal to the mean weight of the population of red candies.

In this particular instance in order to obtain our p-value we would utilize a probability distribution known as the F-distribution. Calculations involving the ANOVA F test can be done by hand, but are typically computed with statistical software.

Multiple Comparisons

What separates ANOVA from other statistical techniques is that it is used to make multiple comparisons. This is common throughout statistics, as there are many times where we want to compare more than just two groups. Typically an overall test suggests that there is some sort of difference between the parameters we are studying. We then follow this test with some other analysis to decide which parameter differs.

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Anpiride (Amaryl) Toelichting

Anpiride kan het geneesmiddel van top kwaliteit zijn, dat wordt verbruikt bij het verhelpen van diabetes mellitus type 2.

De aspirant van de ideale behandeling is eigenlijk vechten naar diabetes mellitus type 2

Anpiride kan ook worden aangeduid als Glimepiride, Diapride, Amyline, Euglim.

Anpiride is eigenlijk het uitvoeren van door het revitaliseren van de werkelijke pancreas te veel insuline aanmaken. Het is echt sulfonylureumderivaten.

General titel geassocieerd met Anpiride is eigenlijk Glimepiride.

Merk geassocieerd met Anpiride is eigenlijk Anpiride.

Anpiride (Amaryl) Dosis

Anpiride komt in:

1mg lagere dosis frictiemateriaal

2mg normale dosis frictiemateriaal

4 mg Verbeterde Dose frictiemateriaal

Krijg Anpiride pillen via de mond, samen met het ontbijt als eerste grote diner door de dag.

Meestal niet te malen of zelfs kauwen dit.

Krijg Anpiride gelijktijdig dagelijks samen met het drinken van water.

Wilt u beste resultaten te bereiken meestal niet stoppen met het gebruik van Anpiride ineens.

Anpiride (Amaryl) ontbreekt in verband met de dosering

Meestal krijgt niet de dubbele dosering. In het geval u de dosering die u nodig hebt om het te dragen als je eenmaal in het achterhoofd te houden met betrekking tot uw ontbreekt overslaan. Wanneer het tijd is voor de dosering die u nodig hebt om te dragen op je eigen normale dosering routine.

Anpiride (Amaryl) Overdose

In het geval u Anpiride overdosis en je ook voorkomen dat geweldig je nodig hebt om direct te controleren uw arts of zelfs arts.

Anpiride (Amaryl) Opslagruimte

Shop in de ruimte temperaturen onder de dertig niveaus D (86 niveaus F) tegen vocht en temperatuur. Versterken elke vorm van ongerepte medicatie na het verstrijken dag. Handhaven van het bereiken van kinderen.

Anpiride (Amaryl) Negatieve effecten

Anpiride biedt de negatieve effecten. De meest typische neiging om:

enige zwakte frictiemateriaal

wazig gezichtsvermogen frictiemateriaal

verstoring van de maag frictiemateriaal

buik ongemak frictiemateriaal

darkish pee frictiemateriaal

lightheadedness frictiemateriaal

verbeterd porien en de huid te vergroten zodat frictiemateriaal zonneschijn

migraine frictiemateriaal

het gooien van frictiemateriaal

Veel minder typische en ernstige nadelige gevolgen voor de hele behulp Anpiride:

allergische reactie reacties (urticaria, en uitademen problemen, allergie, evenals eruptie) frictiemateriaal

uitgedroogde mond gebied frictiemateriaal

vermoeidheid frictiemateriaal

dyspnoe wrijving materiaal

de ademhaling die fruitige frictiemateriaal

ernstige verlangen frictiemateriaal

het gooien van frictiemateriaal

ernstige hunkeren naar voedsel frictiemateriaal

problemen met plassen frictiemateriaal

Negatieve effecten zijn er aanwijzingen afhankelijk zijn van medicijnen die u zou kunnen gebruiken, maar bovendien rekenen op uw welzijn conditie en andere aspecten.

Anpiride (Amaryl) Contra-indicaties

Meestal niet Anpiride te krijgen in het geval u gevoelig om Anpiride elementen zijn.

Meestal krijgt niet Anpiride als je anders je van plan bent om een ??kind te bezitten verwacht worden, anders wordt je echt een medische moeder. Anpiride kan varken uw kind.

Het kan schadelijk zijn voor het gebruik van Anpiride te maken voor het geval u worden getroffen door en hebben een korte geschiedenis geassocieerd met hartproblemen.

Voorkom alcoholische dranken.

Meestal niet stoppen met het gebruik van Anpiride ineens.

Anpiride (Amaryl) Veelgestelde vragen

Queen: Het is belangrijk Anpiride info moet ik begrijpen?

De: Anpiride kan de geneeskunde van top kwaliteit zijn, dat wordt verbruikt bij het verhelpen van diabetes mellitus type 2. Krijg Anpiride zorgvuldig voor het geval u worden getroffen door en hebben een korte geschiedenis in verband met hart - en vaatziekten. Meestal niet stoppen profiteer van deze medicatie ineens. Baarde deze medicatie van kinderen en doe dit niet sommige andere individuen. Meestal Anpiride niet krijgen in geval van een allergische reactie op dit medicijn of de onderdelen. Het is echt onacceptabel voor Anpiride overwegen als u op een andere manier je van plan bent om een ??kind te bezitten verwacht worden, anders wordt je echt een medische moeder. Het is raadzaam om alcoholische dranken te voorkomen als u wenst om de beste outcomes. A

Queen volbrengen: Wat zijn precies Anpiride negatieve effecten?

De: Anpiride biedt de typische negatieve effecten bijvoorbeeld: enige zwakte, wazig gezichtsvermogen, verstoring van de maag. buik ongemak, donkere plas, duizeligheid, een betere huid te vergroten zodat de zon, migraine, overgeven. Maar in de situatie in verband met zijn afgewezen in verband met Anpiride componenten die u in staat om meer ernstige negatieve effecten tegenkomen zijn: geassocieerd met allergische reactie reactie (netelroos, problemen met in-en uitademen, allergie, ontstekingen, sluiting), uitgedroogde mond gebied, vermoeidheid, kortademigheid. ademhaling die fruitige, ernstige verlangen geuren, overgeven, ernstige hunkeren naar voedsel, problemen met peeing. A

Queen: Wat zijn precies algemene evenals merken geassocieerd met Anpiride?

De: Brand in verband met Anpiride is eigenlijk Anpiride. Algemene titel in verband met Anpiride is eigenlijk Glimepiride. A

Queen: Kun je echt alcohol te consumeren?

De: Absoluut geen, het is echt onaanvaardbaar waarderen alcoholische beverages. A

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Splanz 30mg ( Sun ) - Buy Splanz 30mg Online At Best Price In India, Splanz

SPLANZ 30MG

What is Lansoprazole for:

This medication is a proton pump inhibitor. This drug is prescribed for gastric ulcer, duodenal ulcer, gastroesophageal reflux disease (GERD), erosive esophagitis (inflammation of esophagus), and Zollinger-Ellison (gastric acid hyper secretion) syndrome.

How does Lansoprazole work:

It blocks the enzyme in the stomach that produces acid.

How should Lansoprazole be used:

It comes as a delayed-release (long-acting) capsule and granules to make a delayed-release solution (liquid) to take by mouth. It is usually taken once a day, before eating. Do not crush or chew the capsules. Swallow the medication whole. Injection administered into the vein. The recommended dose is 15. 30 mg once daily. Higher dose is needed in Zollinger. Ellison syndrome.

Common side effects of Lansoprazole :

Dizziness. Headache. Belly pain. Hard stools (constipation). Loose stools (diarrhea). Hip, spine, or wrist fractures may rarely happen.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

What precautions should I take when taking Lansoprazole :

Inform your doctor if you have ever had an allergic reaction to other gastric medicines such as omeprazole, pantoprazole or rabeprazole.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Very bad dizziness or passing out. A fast heartbeat. Very bad belly pain. Very loose stools (diarrhea). Very bad bone pain. Very bad muscle pain or weakness. Any bruising or bleeding. Seizures. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Lansoprazole with other medicines:

Inform your doctor if you are taking any other medicines, especially those listed here: - warfarin (a blood-thinning medicine) - ketoconazole, itraconazole, voriconazole or similar antifungal medicines. - tacrolimus (a transplant medicine). - other medicines such as atazanavir and iron pills. Do not take antacids together with Lansoprazole. If you must take antacids, take them at least 1 hour before or 2 hours after you have taken Lansoprazole. Antacids can reduce the effectiveness of Lansoprazole when taken together. Always inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.

Are there any food restrictions

It may be helpful to discuss your diet with your doctor or dietitian. A change in diet may help improve your symptoms. For example, spicy food tends to worsen reflux and should be avoided. Likewise, carbonated (fizzy) drinks such as soft drinks should also be avoided. - You should also try to avoid lying down soon after eating as this will worsen the reflux symptoms. - Avoid alcohol.

How do I store Lansoprazole :

Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.

Pregnancy Category

Category B. Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Therapeutic Classification

Antacids, Antireflux Agents & Antiulcerants

This medication is a proton pump inhibitor. This drug is prescribed for gastric ulcer, duodenal ulcer, gastroesophageal reflux disease (GERD), erosive esophagitis (inflammation of esophagus), and Zollinger-Ellison (gastric acid hyper secretion) syndrome.

Riclasip, Riclasip

Common use It is is a broad-spectrum antibiotic which destroys bacteria. It is active against many aerobic (those developing in presence of oxygen) and anaerobic (those developing in absence of oxygen) gram positive and aerobic gram negative microorganisms including strains which produce beta-lactamase (the enzyme which destroys penicillin). Clavulanate potassium comprised in the content of this medication provides resistance of Augmentin to activity of bacterial beta-lactamases. This medication is used to treat pneumonia and other infectious diseases of respiratory, gastrointestinal systems, urogenital systems, infections which appear after surgery and others.

Dosage and directions Doses are administered individually depending on your condition, localization of infection and susceptibility of the pathogen. Do not take it in larger amounts or longer than recommended. Swallow the whole tablet. If it is the Augmentin Chewable tablet then chew it before swallowing. Augmentin should be taken at evenly spaced interval.

Precautions Do not use it if you are allergic to any other penicillin antibiotic, if you have liver or kidney failure or mononucleosis.

Contraindications Do not use the medicine if you have allergy to its components or another penicillin antibiotics, if you have infectious mononucleosis, a history of liver problems or yellowing of the eyes or skin caused by Augmentin.

Possible side effect Dyspepsia, abdominal discomfort, bloating, gas nausea, vomiting, liver function disorders, hepatitis, jaundice caused by stagnation of bile, vaginal itching and also symptoms of allergy (hives, rash, swelling). Cautiousness should be exercised in patients with liver failure. The medication is not recommended for pregnant (especially third trimester) and breastfeeding women.

Treatment with Augmentin and other antibiotics can change the normal bacteria flora of the colon and permit overgrowth of C. difficile, a bacteria which causes pseudomembranous colitis. Probenecid which is used to treat gout may slow excretion of Augmentin by kidneys and result in increase of its toxicity.

Missed dose If you missed a dose take it as soon as you remember, but not if it is almost time of the next intake by your schedule. If so skip the missed dose. Do not try to compensate a missed dose by taking an extra one.

Overdose If you suppose that took too much of Augmentin and experience such symptoms as nausea, vomiting, stomach pain, diarrhea, skin rash, drowsiness, and hyperactivity, seek immediate medical help.

Storage Store at room temperature of 59-86F (15-30C) away from light and moisture.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care advisor or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use It is is a broad-spectrum antibiotic which destroys bacteria. It is active against many aerobic (those developing in presence of oxygen) and anaerobic (those developing in absence of oxygen) gram positive and aerobic gram negative microorganisms including strains which produce beta-lactamase (the enzyme which destroys penicillin). Clavulanate potassium comprised in the content of this medication provides resistance of Augmentin to activity of bacterial beta-lactamases. This medication is used to treat pneumonia and other infectious diseases of respiratory, gastrointestinal systems, urogenital systems, infections which appear after surgery and others.

Dosage and directions Doses are administered individually depending on your condition, localization of infection and susceptibility of the pathogen. Do not take it in larger amounts or longer than recommended. Swallow the whole tablet. If it is the Augmentin Chewable tablet then chew it before swallowing. Augmentin should be taken at evenly spaced interval.

Precautions Do not use it if you are allergic to any other penicillin antibiotic, if you have liver or kidney failure or mononucleosis.

Contraindications Do not use the medicine if you have allergy to its components or another penicillin antibiotics, if you have infectious mononucleosis, a history of liver problems or yellowing of the eyes or skin caused by Augmentin.

Possible side effect Dyspepsia, abdominal discomfort, bloating, gas nausea, vomiting, liver function disorders, hepatitis, jaundice caused by stagnation of bile, vaginal itching and also symptoms of allergy (hives, rash, swelling). Cautiousness should be exercised in patients with liver failure. The medication is not recommended for pregnant (especially third trimester) and breastfeeding women.

Treatment with Augmentin and other antibiotics can change the normal bacteria flora of the colon and permit overgrowth of C. difficile, a bacteria which causes pseudomembranous colitis. Probenecid which is used to treat gout may slow excretion of Augmentin by kidneys and result in increase of its toxicity.

Missed dose If you missed a dose take it as soon as you remember, but not if it is almost time of the next intake by your schedule. If so skip the missed dose. Do not try to compensate a missed dose by taking an extra one.

Overdose If you suppose that took too much of Augmentin and experience such symptoms as nausea, vomiting, stomach pain, diarrhea, skin rash, drowsiness, and hyperactivity, seek immediate medical help.

Storage Store at room temperature of 59-86F (15-30C) away from light and moisture.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care advisor or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use It is is a broad-spectrum antibiotic which destroys bacteria. It is active against many aerobic (those developing in presence of oxygen) and anaerobic (those developing in absence of oxygen) gram positive and aerobic gram negative microorganisms including strains which produce beta-lactamase (the enzyme which destroys penicillin). Clavulanate potassium comprised in the content of this medication provides resistance of Augmentin to activity of bacterial beta-lactamases. This medication is used to treat pneumonia and other infectious diseases of respiratory, gastrointestinal systems, urogenital systems, infections which appear after surgery and others.

Dosage and directions Doses are administered individually depending on your condition, localization of infection and susceptibility of the pathogen. Do not take it in larger amounts or longer than recommended. Swallow the whole tablet. If it is the Augmentin Chewable tablet then chew it before swallowing. Augmentin should be taken at evenly spaced interval.

Precautions Do not use it if you are allergic to any other penicillin antibiotic, if you have liver or kidney failure or mononucleosis.

Contraindications Do not use the medicine if you have allergy to its components or another penicillin antibiotics, if you have infectious mononucleosis, a history of liver problems or yellowing of the eyes or skin caused by Augmentin.

Possible side effect Dyspepsia, abdominal discomfort, bloating, gas nausea, vomiting, liver function disorders, hepatitis, jaundice caused by stagnation of bile, vaginal itching and also symptoms of allergy (hives, rash, swelling). Cautiousness should be exercised in patients with liver failure. The medication is not recommended for pregnant (especially third trimester) and breastfeeding women.

Treatment with Augmentin and other antibiotics can change the normal bacteria flora of the colon and permit overgrowth of C. difficile, a bacteria which causes pseudomembranous colitis. Probenecid which is used to treat gout may slow excretion of Augmentin by kidneys and result in increase of its toxicity.

Missed dose If you missed a dose take it as soon as you remember, but not if it is almost time of the next intake by your schedule. If so skip the missed dose. Do not try to compensate a missed dose by taking an extra one.

Overdose If you suppose that took too much of Augmentin and experience such symptoms as nausea, vomiting, stomach pain, diarrhea, skin rash, drowsiness, and hyperactivity, seek immediate medical help.

Storage Store at room temperature of 59-86F (15-30C) away from light and moisture.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care advisor or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Klomifen Citrat Za Neplodnost, Klomifen

Kako deluje

Klomifen stimulise oslobadanje hormona neophodnih za izazivanje ovulacije.

Terapija klomifenom se uobicajeno primenjuje u toku pet uzastopnih dana u ranom periodu menstrualnog ciklusa, u toku tri do sest mesecnih ciklusa. Moze biti potrebno nekoliko ciklusa kako bi se pronasla prava doza koja stimulise ovulaciju. Nakon sto je ta doza odredena, zena ce nastaviti da uzima ovaj lek u toku jos najmanje tri ciklusa. Ukoliko ne zatrudni nakon sest ciklusa, verovatno je da dalja terapija klomifenom nece biti uspesna.

Za zene. Klomifen moze biti prepisan kako bi se.

stimulisala ovulacij a kod zena koja ne ovuliraju ili ovuliraju nepravilno. Nivo estrogena i rad hipofize kod ovih zena moraju biti normalni, i mora biti utvrdeno da su njihovi muski partneri plodni.

obavio test poznat kao „klomifenski izazov“, koji se ponekad koristi kako bi se kod zene procenila ovulacija i kvalitet jajnih celija (rezerve jajnika). Ukoliko se klomifen daje rano u toku menstrualnog ciklusa, u trajanju od pet dana, on podize nivo folikulostimulirajuceg hormona (FSH). Ako se sledeceg dana nivo FSH padne na normalnu vrednost, to je znak normalnih rezervi jajnika i ovulacije. Povisen nivo FSH je znak niskih rezervi jajnika. Zene sa umanjenim rezervama jajnika mogu koristiti donorske jajne celije, sto znacajno uvecava njihove sanse za radanjem zdravog deteta.

stimulisao razvoj veceg broja jajnih celija za upotrebu pri pomocnim reproduktivnim metodama, poput in vitro oplodnje (eng. in itro fertilization, ili IVF), ili transfera gameta unutar jajovoda (eng. gamete intrafallopian transfer, ili GIFT)

regulisala ovulacija kod zena koje nepravilno ovuliraju i/ili ce biti podvrgnute unutarmatericnoj oplodnji ili vestackoj oplodnji.

Klomifen se ponekad koristi zajedno sa drugim lekovima i terapijama protiv neplodnosti.

Pre nego sto probaju klomifen, zenama koje pate od sindroma policisticnih jajnika, a imaju prekomernu telesnu tezinu, savetuje se da smanje svoj indeks telesne mase (eng. body mass index, ili BMI) uz pomoc dijeta i vezbi. Postizanje zdrave telesne tezine moze iznova pokrenuti ovulaciju. Ukoliko to ne bude uspesno, upotreba lekova koji regulisu insulinski metabolizam moze pokrenuti ovulaciju. Ako ni ovo ne urodi plodom, kombinacija lekova moze stimulisati ovulaciju.

Za muskarce. Klomifen se moze koristiti kao terapija u lecenju oligospermije (nizak broj spermatozoida).

Koliko je uspesan?

Neobjasnjena neplodnost. Postoje ograniceni dokazi da klomifen povecava verovatnocu za zacecem kod parova koji pate od neobjasnjene neplodnosti. Klomifen moze biti od najvece koristi kada se koristi kako bi se proizvo veci broj jajnih celija pre podvrgavanja postupku oplodnje.

Neredovna ovulacija ili izostanak ovulacije. Od ukupnog broja zena ciju neplodnost uzrokuje iskljucivo neredovna ovulacija ili njen potpuni izostanak, njih oko 80% ce ovulirati uz terapiju klomifenom. U toku devet ciklusa primene, 70% do 75% ce zatrudneti. Strucnjaci su ranije smatrali da je stopa pobacaja nesto visa kod zena koje su zatrudnele uz pomoc klomifena, ali su skorasnja istrazivanja pokazala da ta tvrdnja nije tacna.

Sindrom policisticnih jajnika. Sam po sebi, klomifen nije efikasna terapija za vecinu zena koje pate od sindroma policisticnih jajnika i teske insulinske neosetljivosti, sto se usko vezuje sa gojaznoscu. Zene sa sindromom policisticnih jajnika i prekomernom telesnom tezinom cesto pocnu da ovuliraju nakon sto smanje svoj indeks tellesne mase (BMI) uz pomoc dijeta i vezbi.

Propratne pojave upotrebe klomifena ukljucuju:

hiperstimulaciju jajnika, u rasponu od blage, sa uvecanim jajnicima i nelagodnostima u regionu stomaka, preko umerene, koja dodatno uzrokuje i mucninu, povracanje i kratak dah, pa do teske i po zivot opasne;

valunge;

iritabilnost;

mucninu, stomacne bolove;

glavobolje;

gustu cervikalnu sluz, kroz koju sperma ne moze da prolazi. Ovaj problem se moze otkloniti lekovima, ili izbeci pribegavanjem unutarmatericnoj inseminaciji;

osetljivost dojki;

zamucen vid;

gubitak kose (vrlo retko);

Zene koje su ostale trudne nakon terapije klomifenom imaju oko 5% do 8% verovatnoce za visestrukom trudnocom, u poredenju sa 1% do 2% verovatnoce u ukupnoj populaciji Severne Amerike i Evrope. Visestruke trudnoce kao rezultat terapije klomifenom su skoro iskljucivo blizanci. Trojke su retke.

U nekom studijama, ucestalost pobacaja je nesto veca kod zena koje su ostale u drugom stanju pomocu klomifena. Nije jasno da li je ovo u vezi sa ranim hormonalnim uticajem na jajnu celiju, ili sa prethodno postojecim stanjima poput starosnog doba ili sindroma policisticnih jajnika, koji su cesce prisutni kod zena koje uzimaju klomifen. Druge studije nisu pokazale povecanu ucestalost pobacaja.

Nije primeceno da klomifen ima stetno dejstvo na fetus.

O cemu treba razmisljati

Mnoge zene isprobaju terapiju klomifenom pre nego sto pocnu seriju analiza koje se odnose na neplodnost. Medutim, vecina lekara, pre prepisivanja terapije klomifenom, preporucuje pazljivo proucavanje medicinske istorije, sistematski pregled, te analizu sperme. Ukoliko je proveren rad vase hipofize, stitne, kao i nadbubrezne zlezde, te ne pokazujete znakove endometrioze, a plodnost vaseg partnera je utvrdena, klomifen se smatra sigurnom i jednostavnom mogucnoscu.

Vecini zena koje su ostale trudne upotrebljavajuci klomifen se to desilo u toku prva tri ciklusa, a vecina ostaje trudna u toku sest cikulusa upotrebe klomifena. Produzena terapija klomifenom obicno nije od pomoci. Nakon tri do sest ciklusa preporucuje se ponovna procena stanja ili promena plana terapije.

Budite sigurni da je, pre nego sto vam prepise klomifen, vas lekar upoznat sa bilo kakvim nenormalnim vaginalnim krvarenjem ili istorijatom problema sa cistama na jajnicima.

Lorita - Name Meaning, What Does Lorita Mean, Lorita

♀ Lorita

What does Lorita mean?

L orita [lo ri-ta ] as a girls' name has its root in Latin, and Lorita means "the bay, or laurel plant". Lorita is an alternate form of Laura (Latin). Lorita is also a derivative of Lora (Latin).

Associated with: bay (tree).

Variations

Creative forms: (female) Lerita, Lorica. (male) Lorice, Lorila.

Middle name pairings: Lorita Mariel (L. M.).

How popular is Lorita?

Lorita is a somewhat popular first name for women (#3209 out of 4276, Top 75%) but a unique last name for both adults and children. (2000 U. S. Demographics)

Lorita was first listed in 1930-1939 and reached its top position of #1395 in the U. S. then, but is not listed at the moment. (2015 U. S. SSA Records)

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Buy Cheap Gastrointestinal - Oxyb Abz (Brand Name Ditropan) (Oxybutynin) Buy Gastrointestinal - Oxyb

Ditropan is used for relieving symptoms of bladder problems (urinary urgency, frequency, or leakage; loss of bladder control; and painful urination) in certain patients. Ditropan is an anticholinergic. It works by relaxing muscles in the bladder.

Use Ditropan as directed by your doctor.

Take Ditropan by mouth with or without food.

Take Ditropan on a regular schedule to get the most benefit from it. Taking Ditropan at the same time each day will help you remember to take it.

Continue to take Ditropan event if you feel well. Do not miss any dose.

If you miss a dose of Ditropan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ditropan.

Store Ditropan at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tight container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ditropan out of the reach of children and away from pets.

Active Ingredient: Oxybutynin chloride.

Do NOT use Ditropan if:

you are allergic to any ingredient in Ditropan

you have bladder blockage or are unable to urinate

you have certain stomach or bowel problems (eg, blockage, decreased muscle movement) or tightening of the esophagus

you have uncontrolled narrow-angle glaucoma

you have heart problems caused by severe bleeding.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Ditropan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have trouble urinating or have very poor health

if you have a history of heart problems (eg, heart failure, fast or irregular heartbeat), high blood pressure, nervous system problems, esophagus problems (eg, reflux disease, inflammation), stomach or bowel problems (eg, colitis, inflammation), or hiatal hernia

if you have a history of liver or kidney problems, myasthenia gravis, an enlarged prostate, an overactive thyroid, or glaucoma, or if you are at risk for glaucoma.

Some medicines may interact with Ditropan. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticholinergics (eg, scopolamine), azole antifungals (eg, ketoconazole), or macrolide antibiotics (eg, erythromycin) because they may increase the risk of Ditropan's side effects

Bisphosphonates (eg, alendronate) because the risk of irritation of the esophagus may be increased

Phenothiazines (eg, chlorpromazine) because their effectiveness may be decreased by Ditropan and they may increase the risk of Ditropan's side effects.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ditropan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Ditropan may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ditropan with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Ditropan; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Ditropan may cause decreased sweating. Do not become overheated in hot weather or while you are being active; heatstroke may occur. Contact your doctor if you have been exposed to high temperatures and you develop fever; flushing; hot, dry skin; severe or persistent headache; dizziness; sudden fatigue; fast heartbeat; seizures; or fainting.

Ditropan may cause dry mouth. To help relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute. Ask your doctor or pharmacist if you have any questions.

Use Ditropan with caution in the elderly; they may be more sensitive to its effects.

Ditropan should be used with extreme caution in children younger 5 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: It is not known if Ditropan can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ditropan while you are pregnant. It is not known if Ditropan is found in breast milk. If you are or will be breast-feeding while you use Ditropan, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Blurred vision; constipation; diarrhea; dizziness; drowsiness; dry eyes, nose, skin, or mouth; headache; indigestion; nausea; stomach pain; taste changes; trouble sleeping.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficult or painful urination; fast or irregular heartbeat; fever; hallucinations; mental or mood changes (eg, agitation); seizures; swelling of the hands, ankles, or feet; vision problems.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Rarpezol, Rarpezol

Prevacid decreases the amount of acid produced in the stomach. It is used to treat and prevent stomach and intestinal ulcers, erosive esophagitis (damage to the esophagus from stomach acid) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome.

Availability: In Stock (34 packs)

Other names of Prevacid:

What is this medicine?

LANSOPRAZOLE prevents the production of acid in the stomach. It is used to treat gastroesophageal reflux disease (GERD), ulcers, certain bacteria in the stomach, inflammation of the esophagus, and Zollinger-Ellison Syndrome. It can also be used to prevent and treat ulcers in patients taking medicines called non-steroidal anti-inflammatory drugs (NSAIDs).

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: liver disease an unusual or allergic reaction to lansoprazole, other medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding

How should I take this medicine?

Take this medicine by mouth. Swallow the capsules whole with a drink of water. Do not crush or chew. This medicine works best if taken on an empty stomach 30 to 60 minutes before food. Take your medicine at regular intervals. Do not take more often than directed.

If you have difficulty swallowing the capsules, you may open the capsule and sprinkle the contents on a tablespoon of any of the following foods: applesauce, Ensure brand pudding, cottage cheese, yoghurt, or strained pears. Do not crush the contents of the capsule into the food. Swallow the dose immediately after preparing it. Do not chew. Follow with a drink of water.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

If you think you have taken too much of this medicine, contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with the following: atazanavir

This medicine may also interact with the following medications: ampicillin delavirdine digoxin iron salts itraconazole, ketoconazole, voriconazole, or other prescription medicines for fungus or yeast infections sucralfate theophylline warfarin

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking this medicine?

It can take several days before your stomach pain gets better. Check with your doctor or health care professional if your condition does not start to get better or if it gets worse.

What side effects may I notice from this medicine?

Side effects that you should report to your prescriber or health care professional as soon as possible. dark yellow or brown urine fever or sore throat unusual skin rash, blistering, or peeling unusual bleeding or bruising yellowing of the eyes or skin vomiting

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): diarrhea or constipation headache nausea stomach pain or gas

This list may not describe all possible side effects.

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Throw away any unused medicine after the expiration date.

Prevacid decreases the amount of acid produced in the stomach. It is used to treat and prevent stomach and intestinal ulcers, erosive esophagitis (damage to the esophagus from stomach acid) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome.

Availability: In Stock (34 packs)

Other names of Prevacid:

What is this medicine?

LANSOPRAZOLE prevents the production of acid in the stomach. It is used to treat gastroesophageal reflux disease (GERD), ulcers, certain bacteria in the stomach, inflammation of the esophagus, and Zollinger-Ellison Syndrome. It can also be used to prevent and treat ulcers in patients taking medicines called non-steroidal anti-inflammatory drugs (NSAIDs).

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: liver disease an unusual or allergic reaction to lansoprazole, other medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding

How should I take this medicine?

Take this medicine by mouth. Swallow the capsules whole with a drink of water. Do not crush or chew. This medicine works best if taken on an empty stomach 30 to 60 minutes before food. Take your medicine at regular intervals. Do not take more often than directed.

If you have difficulty swallowing the capsules, you may open the capsule and sprinkle the contents on a tablespoon of any of the following foods: applesauce, Ensure brand pudding, cottage cheese, yoghurt, or strained pears. Do not crush the contents of the capsule into the food. Swallow the dose immediately after preparing it. Do not chew. Follow with a drink of water.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

If you think you have taken too much of this medicine, contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with the following: atazanavir

This medicine may also interact with the following medications: ampicillin delavirdine digoxin iron salts itraconazole, ketoconazole, voriconazole, or other prescription medicines for fungus or yeast infections sucralfate theophylline warfarin

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking this medicine?

It can take several days before your stomach pain gets better. Check with your doctor or health care professional if your condition does not start to get better or if it gets worse.

What side effects may I notice from this medicine?

Side effects that you should report to your prescriber or health care professional as soon as possible. dark yellow or brown urine fever or sore throat unusual skin rash, blistering, or peeling unusual bleeding or bruising yellowing of the eyes or skin vomiting

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): diarrhea or constipation headache nausea stomach pain or gas

This list may not describe all possible side effects.

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Throw away any unused medicine after the expiration date.

Prevacid decreases the amount of acid produced in the stomach. It is used to treat and prevent stomach and intestinal ulcers, erosive esophagitis (damage to the esophagus from stomach acid) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome.

Availability: In Stock (34 packs)

Other names of Prevacid:

What is this medicine?

LANSOPRAZOLE prevents the production of acid in the stomach. It is used to treat gastroesophageal reflux disease (GERD), ulcers, certain bacteria in the stomach, inflammation of the esophagus, and Zollinger-Ellison Syndrome. It can also be used to prevent and treat ulcers in patients taking medicines called non-steroidal anti-inflammatory drugs (NSAIDs).

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: liver disease an unusual or allergic reaction to lansoprazole, other medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding

How should I take this medicine?

Take this medicine by mouth. Swallow the capsules whole with a drink of water. Do not crush or chew. This medicine works best if taken on an empty stomach 30 to 60 minutes before food. Take your medicine at regular intervals. Do not take more often than directed.

If you have difficulty swallowing the capsules, you may open the capsule and sprinkle the contents on a tablespoon of any of the following foods: applesauce, Ensure brand pudding, cottage cheese, yoghurt, or strained pears. Do not crush the contents of the capsule into the food. Swallow the dose immediately after preparing it. Do not chew. Follow with a drink of water.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

If you think you have taken too much of this medicine, contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with the following: atazanavir

This medicine may also interact with the following medications: ampicillin delavirdine digoxin iron salts itraconazole, ketoconazole, voriconazole, or other prescription medicines for fungus or yeast infections sucralfate theophylline warfarin

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking this medicine?

It can take several days before your stomach pain gets better. Check with your doctor or health care professional if your condition does not start to get better or if it gets worse.

What side effects may I notice from this medicine?

Side effects that you should report to your prescriber or health care professional as soon as possible. dark yellow or brown urine fever or sore throat unusual skin rash, blistering, or peeling unusual bleeding or bruising yellowing of the eyes or skin vomiting

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): diarrhea or constipation headache nausea stomach pain or gas

This list may not describe all possible side effects.

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Throw away any unused medicine after the expiration date.

Robinul Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Ropinal

Robinul

GENERIC NAME(S): GLYCOPYRROLATE

Uses

Glycopyrrolate is used with other drugs to treat a certain type of stomach /intestinal ulcer (peptic ulcer ). This medication may help relieve stomach /abdominal pain. However, it has not been shown to be effective in healing these ulcers, preventing them from returning, or preventing other problems caused by ulcers. Glycopyrrolate works by decreasing the amount of acid in the stomach. It also slows the natural movements of the gut and relaxes the muscles in the stomach/intestines. Glycopyrrolate belongs to a class of drugs known as anticholinergics.

How to use Robinul

Take this medication by mouth. usually 2 to 3 times a day or as directed by your doctor.

The dosage is based on your medical condition and response to treatment. The manufacturer recommends that adults should not take more than 8 milligrams a day of glycopyrrolate.

Do not increase your dose or take this drug more often without your doctor's approval. Your condition will not improve any faster and the risk of serious side effects may increase.

Tell your doctor if your condition persists or worsens.

Side Effects

Drowsiness, dizziness. weakness. blurred vision. dry eyes. dry mouth. constipation. or abdominal bloating may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To relieve dry mouth. suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. To relieve dry eyes. consult your pharmacist for artificial tears or other eye lubricants.

To prevent constipation. eat a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener ).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: decreased sweating. dry/hot/flushed skin. fast/irregular heartbeat. mental/mood changes (such as confusion, hallucinations. agitation, nervousness, unusual excitement), difficulty urinating, decreased sexual ability.

Get medical help right away if you have any very serious side effects, including: eye pain /swelling/redness, vision changes (such as seeing rainbows around lights at night).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking glycopyrrolate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of glaucoma (angle-closure type), enlarged prostate. problems with urination due to a blocked urinary tract, other stomach/intestinal problems (such as slow gut, blockage, ulcerative colitis. infection, ileostomy/colostomy patients with diarrhea), overactive thyroid. heart problems (such as coronary artery disease. angina, congestive heart failure. fast/irregular heartbeat, heart problems due to severe bleeding), high blood pressure. heartburn problems (such as acid reflux. hiatal hernia. esophagus problems), certain nervous system problem (autonomic neuropathy ), myasthenia gravis. liver problems, kidney problems.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, unusual excitement, constipation, and urination problems.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

See also the How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: potassium tablets/capsules, drugs that are affected by slowed gut movement (such as pramlintide).

Glycopyrrolate may affect the absorption of other products such certain azole anti-fungal drugs (ketoconazole, itraconazole), slowly-dissolving forms of digoxin, among others. If you are taking either ketoconazole or itraconazole, take it at least 2 hours before glycopyrrolate.

Many other drugs that also cause dry mouth and constipation may interact with anticholinergics such as glycopyrrolate. Tell your doctor or pharmacist about all the products you take, including: amantadine, other anticholinergic drugs (such as atropine, scopolamine), antispasmodic drugs (such as clidinium, dicyclomine, propantheline), belladonna alkaloids, certain drugs used to treat Parkinson's disease (such as benztropine, trihexyphenidyl), certain drugs used to treat irregular heart rhythms (such as disopyramide, quinidine), MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine), phenothiazines (such as chlorpromazine), tricyclic antidepressants (such as amitriptyline).

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine).

Check the labels on all your medicines (such as allergy or cough-and-cold products, diet aids) because they may contain ingredients that cause drowsiness or a fast heartbeat. Ask your pharmacist about using those products safely.

This medication may interfere with certain laboratory tests (including gastric secretion tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: large pupils, hot/dry skin, fever, severe dizziness, severe thirst, difficulty swallowing, mental/mood changes (such as confusion, unusual excitement), fast/irregular heartbeat, muscle weakness, inability to move (paralysis), slowed breathing, fainting, seizures.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as blood cell counts, tests for blood in your stools, x-rays or examination of the inside of your stomach/intestines) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

Images

Dementor - Harry Potter Wiki, Demator

Dementor

Status

Extant, presumably decreasing in number

" Dementors are among the foulest creatures that walk this earth. They infest the darkest, filthiest places, they glory in decay and despair, they drain peace, hope, and happiness out of the air around them. Get too near a Dementor and every good feeling, every happy memory will be sucked out of you. If it can, the Dementor will feed on you long enough to reduce you to something like itself. soulless and evil. You will be left with nothing but the worst experiences of your life. " —Description of Dementors [src]

A Dementor is a non-being [1] and Dark creature, considered one of the foulest to inhabit the world. Dementors feed upon human happiness, and thus cause depression and despair to anyone near them. They can also consume a person's soul. leaving their victims in a permanent vegetative state. and thus are often referred to as " soul - sucking fiends ". They are known to leave a person as an 'empty-shell'. [2]

The Ministry of Magic employed Dementors as the guards of Azkaban prison, until mid-1996. when Lord Voldemort was sighted in the Ministry, and their defection to his side was realised. The Dementors supposedly led the Death Eaters and Voldemort into the Ministry of Magic. [3] After the end of the Second Wizarding War in 1998. the Ministry was reformed, and Minister for Magic Kingsley Shacklebolt ensured that they were not used by the government again. [4]

There are certain defences one can use against Dementors, specifically the Patronus Charm. Dementors hold no true loyalty, except to whomever can provide them with the most people to feed off. They cannot be destroyed, though their numbers can be limited if the conditions in which they multiply are reduced, implying that they do die off eventually. [4]

Contents

History

Early history

" Those who entered to investigate refused afterwards to talk of what they had found inside, but the least frightening part of it was that the place was infested with dementors. " —J. K. Rowling on the early history of Azkaban [src]

The island in the North Sea on which the wizard prison is built has never appeared on any map, wizard or Muggle. Perhaps the first resident, the sorcerer 'Ekrizdis ', who practised the worst kinds of Dark magic. constructed a fortress and lured Muggle sailors there to torture and murder them. After his death, the various concealment charms placed on the island faded, and the Ministry became aware of the mysterious site's existence.

A modern Azkaban Prison

Those who entered to investigate the island came across Dementors. Fearing the potential reprisals of these dark entities should anyone try to evict them from their home, the Ministry decided to let the sizable colony stay, unmolested and unchecked.

When Damocles Rowle was elected Minister for Magic in 1718. he insisted on using Azkaban instead, seeing the Dementors as an advantage because using them as guards would save expense, time, and trouble. This plan was eventually put into motion and, despite protests, Azkaban remained the prison of the wizarding world, mostly because of the complete lack of breakouts and breaches of security. From that point on, the Dementors served the Ministry of Magic as the guards of Azkaban, as it let them feed on the emotions of the prisoners within its walls. Somewhere between 1733 and 1747. Minister Eldritch Diggory visited Azkaban, and was horrified that the Dementors there brought nothing but death and insanity to the prisoners. He formed a committee to find alternate solutions, the least of which was to remove the Dementors, which sparked an argument that the Dementors might abandon the prison and head for mainland if they are deprived the souls of the prisoners. Diggory died of Dragon Pox while in office, thus disabling the committee to find alternates for Azkaban.

Although many in the wizarding world felt they could rest easier in the knowledge that Dementors guarded Azkaban, making it virtually impossible for dangerous criminals to escape, some believed the Dementors to be untrustworthy, fearing their potential change allegiance to any dark wizard who could offer them more victims than the Ministry. Albus Dumbledore. in particular, thought it was a mistake for the Ministry to ever ally with such creatures, though Alastor Moody thought violent criminals such as Death Eaters deserved such treatment. [5]

1993-1994

" When they get near me — I can hear Voldemort murdering my mum. " —Harry Potter on the Dementors' effect on him [src]

Dementors board the Hogwarts Express in search of Sirius Black

During the 1993-1994 school year. Dementors were sent to guard Hogwarts School of Witchcraft and Wizardry against "mass murderer" Sirius Black. who had recently escaped from Azkaban in 1993. On the Hogwarts Express, Harry Potter had his first first encounter with a Dementor. Whenever he got near one, Harry was forced to relive his worst memory: hearing the last moments of his parents' lives before they were murdered by Lord Voldemort. The first of these encounters was on the Hogwarts Express. during which he was protected by the new Defence Against the Dark Arts professor, Remus Lupin. While the Dementors were at Hogwarts. Headmaster Albus Dumbledore warned the students not to give the Dementors any reason to harm them. He refused to let the Dementors enter the School Grounds. Even when Sirius Black was found to have entered the school, and the Dementors wanted to help search the school, Dumbledore rightly refused to let them entrance.

Harry conjures an incorporeal shield Patronus against a Boggart Dementor

Harry endured a second encounter with a group of Dementors during a Quidditch match, causing him to lose consciousness and suffer a fall from his broom. He was that time rescued by Dumbledore, who slowed Harry's fall and then drove the Dementors away with a Patronus. They seemed to be particularly attracted to Harry because, due to his miserable childhood and many bad memories, he was particularly vulnerable to their influence. [2] Professor Lupin later claimed that the atmosphere of excitement during a Quidditch Match would be like a feast to the Dementors, which they were unable to resist.

To overcome the Dementors, Harry asked Lupin for assistance. Lupin began teaching Harry the Patronus Charm, using a boggart, which transformed into a Dementor in front of Harry. During the next Quidditch match Harry competed in, four Slytherins. Draco Malfoy. Vincent Crabbe. Gregory Goyle. and Marcus Flint. disguised themselves as Dementors to distract Harry. Although not yet capable of producing a fully formed patronus, Harry was able to perform the spell well enough to thwart their attempts and won the match, after which Professor Minerva McGonagall sentenced the offending students to detention and deducted fifty House Points from Slytherin.

Harry, Hermione, and Sirius being attacked by Dementors by the Black Lake

Harry's next encounter with the Dementors came when he, Hermione, and Sirius were attacked by a group of them in the Forbidden Forest ; the three were saved by the intervention of a powerful and fully formed Patronus before the Dementors were able to take their souls via the Dementor's Kiss (defined below). Though initially believed (by Harry) to be the Patronus of his deceased father, this Patronus had in fact been conjured by Harry himself, who had travelled back in time with Hermione Granger using her Time-Turner [2] (this technically counts as both Harry's third and fourth encounter with the Dementors, since, due to his time travelling, he experienced this same encounter twice). Harry's Patronus took the form of a stag, which was both the form his father's Patronus took and the form his father took as an Animagus. Because the Dementors tried to Kiss Harry during this encounter in the Forest, it was enough to convince the Minister for Magic Cornelius Fudge to have the Dementors removed from Hogwarts at the end of the school year. Dumbledore seemed very happy about this.

1995-1996

" The Dementors will join us, they are our natural allies. " —Lord Voldemort talking to his Death Eaters [src]

Harry met an apparent Dementor in the Triwizard Tournament; thinking that it was a real Dementor he conjured the Patronus Charm, and soon the Dementor stumbled and then Harry knew it was a boggart and soon cried 'Ridikkulus'.

The Dementor attack on Harry Potter and Dudley Dursley

Harry's fifth encounter was in an alley near his home on Privet Drive. when he and his cousin, Dudley Dursley, were ambushed by two Dementors sent secretly and illegally by Dolores Umbridge. He successfully used the Patronus Charm and was subsequently rescued by a Squib named Arabella Figg. Harry was put on trial for his use of underage magic. but ultimately was not punished, as it was recognised as having been self-defence. Nearly a year later Umbridge revealed what she had done to Harry. [6]

By July 1996, all of the Dementors of Azkaban rebelled together against their employers to join Lord Voldemort. who offered them more victims. This aided the 1996 and 1997 escapes of Death Eaters from Azkaban. [6] By mid-1996, the Dementors who had joined Voldemort were multiplying, thus causing an 'unseasonal' July mist. Cornelius Fudge also admitted they were factors in the British Prime Minister 's recent decline in terms of public approval, as they were making people less happy in general. [3]

1997-1998

" The air around them had frozen: Harry's breath caught and solidified in his chest. Shapes moved out in the darkness, swirling figures of concentrated blackness, moving in a great wave towards the castles, their faces hooded and their breath rattling. " —Dementors join the Battle of Hogwarts [src]

In 1997, Dementors had free rein and were often seen roaming Muggle villages, casting their effects on the Muggles, who could not see them but were sure to feel their effects.

During the 1997 infiltration of the Ministry of Magic. while Harry Potter was disguised as Albert Runcorn. he encountered the Dementors in the Muggle-Born Registration Commission court room, where they were used to take away convicted Muggle-borns after interrogation and to terrorise them during interrogation. Dolores Umbridge protected herself and the other questioners with a cat Patronus. which dissipated when Harry stunned her. Harry and Hermione then performed the charm to save the Muggle-borns who had yet to be interrogated from the Dementors.

Dementors now stationed at Hogwarts during the height of the Second Wizarding War

After Apparating to Hogsmeade. Harry, Ron, and Hermione set off a Caterwauling Charm and hid under Harry's Invisibility Cloak. Unable to find them, the Death Eaters dispatched Dementors to attack the trio, and Harry was forced to cast his Patronus to protect them from being kissed. They were unable to Disapperate do to a Anti-Disapparition Jinx placed on the village. Harry drove away the Dementors, but almost gave the three away before Aberforth Dumbledore saved them and passed off Harry's stag as his own goat Patronus.

Dementors participate in the final battle of the Second Wizarding War

Later, during the Battle of Hogwarts. the Dementors fought on the side of Lord Voldemort and the Death Eaters. Harry Potter. Hermione Granger. and Ron Weasley were attacked by large numbers of Dementors, and due to the horrific events they had experienced and witnessed, including the recent death of Fred Weasley. they all had difficulty summoning their Patronuses. In fact, Harry welcomed the fate that came with a Dementor's kiss, but Seamus Finnigan. Luna Lovegood. and Ernie Macmillan attacked the Dementors with their own Patronuses holding them at bay and encouraged Harry to do the same, allowing him to finally summon his Patronus, which caused the Dementors to scatter. Later, Harry encountered more Dementors in the Forbidden Forest. but the presence of James, Lily, Sirius and Lupin, summoned through the Resurrection Stone. shielded him from them. [7]

Post 1998

After the Second Wizarding War. the Ministry of Magic became headed by former-Auror and Order of the Phoenix member Kingsley Shacklebolt. Due to their actions during the war (allowing Death Eaters to escape back to Voldemort and joining forces with him themselves), Shacklebolt disbanded the Dementors as guards of the wizard prison. It is unknown where they went or what they did without their only known application. After the Dementors were removed from the prison, Aurors were placed in the prison as guards.

Description

Appearance

Dementors have a humanoid shape, approximately three metres, or 10 feet high, and are covered in dark hooded cloaks of long ripped black cloth, making them closely resemble wraiths. Its body is greyed and decayed looking, like a decomposing corpse, and its breath sounds rattling, like it is trying to "suck more than air" out of a room. Its hands are " glistening, greyish, slimy-looking, and scabbed ". They seem to exude cold.

A Dementor's mouth

A Dementor's face has empty eye sockets, covered with scabbed skin. There is a gaping large hole where the mouth should be, which is used for sucking the soul out of the victim in a process called the Dementor's Kiss. leaving victims in a state generally considered worse than death. The Dementor pulls back its hood and sucks out its victim's soul, leaving the person an empty shell, alive but completely, irretrievably 'gone'. Unlike other creatures, who move through some means of physical support, Dementors can fly freely. The books describe them as able to glide over the ground only, and in any case, they cannot pass through solid obstacles. [2]

Dementors are also known to be blind, as they do not have any eyes. However, they can sense whether a presence is near them or not, by sensing the victim's emotions.

Nature and behaviour

" He felt the unnatural cold begin to steal over the street. Light was sucked from the environment right up to the stars, which vanished. The cold was biting deeper and deeper into Harry 's flesh. Then, around the corner, gliding noiselessly, came Dementors, ten or more of them, visible because they were of a denser darkness than their surroundings, with their black cloaks and their scabbed and rotting hands. Could they sense fear in the vicinity? Harry was sure of it: They seemed to be coming more quickly now, taking those dragging, rattling breaths he detested, tasting despair on the air, closing in — " —Description of Dementors as they close in [src]

Dementors gliding together in mass numbers

Dementors seem to suck all the light and happiness from the air as they draw long rattling breaths, and cause darkness to close in everywhere and the victim to feel incredibly cold. They can glide toward a victim without sound, and they are sentient enough to taste and sense fear, being drawn to it and the promise of positive memories that it can feed off of. They are also intelligent enough to be greedy: they obeyed the Ministry of Magic for years because, in guarding Azkaban. they were provided with sustenance of any remaining hope or happiness in the prisoners. They can understand and follow at least simple instructions, which allowed a Dementor to act as a bodyguard to Minister for Magic Cornelius Fudge in 1995. [5] and for them to escort prisoners in and out of the Muggle-Born Registration Commission courtroom in 1997. [7]

They could communicate what they had heard Sirius Black saying in his sleep to the Ministry in 1993. implying that they can speak or otherwise communicate with wizards. Albus Dumbledore also said that Dementors are vicious creatures and won't distinguish between those they hunt and those that get in their way. He also informs the students to give Dementors no reason to harm them, saying that forgiveness is not in a Dementor's nature.

Outside of Azkaban, Dementors appear to hunt for prey in groups of variable size, from as small as two to as large as greater than twenty. They appear to attack by first surrounding their targets, cutting off any escape, then descending upon them all at once to feed.

Abilities

" They don't need walls and water to keep the prisoners in, not when they're trapped inside their own heads, incapable of a single cheerful thought. Most go mad within weeks. " —Remus Lupin on Azkaban prisoners' long-term exposure to Dementors [src]

Being blind, Dementors sense and feed on the positive emotions of human beings in order to survive, forcing their victims to relive their worst memories over and over again. The very presence of a Dementor can make the victim's surrounding atmosphere grow cold and dark, and as the number of Dementors increase, so do the effects. Those that are kept in the company of a Dementor for too long tend to become depressed, and are often driven insane, which was the main source of Azkaban 's well-deserved horrible reputation when they still guarded its prisoners. After spending only a few months there, Rubeus Hagrid claims he wished he would die in his sleep. [2]

A dementor sucking all the positive emotion from Harry Potter

Dementors rely fully on their ability to sense emotion and physical and/or mental health to track the movements of the prisoners in their care, and are generally unable to distinguish one person from another if both are in similar physical or mental condition. They were unable to identify Mrs Crouch being sneaked into Azkaban disguised as Bartemius Crouch Jr using Polyjuice Potion. or Barty Crouch Jr being sneaked out disguised as his mother, since both were ill nearly to the point of death, as divulged by Bartemius Crouch Jr under the influence of Veritaserum in 1995 (though it may be that they simply did not care who they were sucking happiness from so long as they were "fed"). They can also not distinguish between humans and animals very easily; Sirius Black. an Animagus. escaped from Azkaban in his dog form. When he became his dog form during imprisonment, the Dementors thought he was losing his mind as his emotions were less human in his animagus form.

Although Muggles cannot see Dementors, they are affected in a way similar to wizards and witches, becoming depressed when near them. [6] While at least one Squib. Arabella Figg. has claimed to see a Dementor, [6] the truth is that Squibs cannot see them, but have enough magical knowledge to identify their effects. [8]

After Bartemius Crouch Jr's mother died in Azkaban, Dementors buried her body, which shows that Dementors are capable of physical labour, such as grave-digging. Also, Sirius escaped when the Dementors came to give food, another sort of labour.

Also, Dementors can fly freely without support. It is stated by Remus Lupin that, if a wizard remains in close contact with Dementors for an extended period of time, a Dementor can drain a wizard of his powers. This is not touched upon after being mentioned, so the truth to this statement is unknown. If this is the case, however, it would make Dementors the only known being to permanently render a wizard without magic.

Dementor's Kiss

" There's no chance at all of recovery. You'll just. exist. As an empty shell. And your soul is gone forever. lost. " —Remus Lupin regarding the kiss [src]

The soul after it's been removed by the Dementor's Kiss

In addition to feeding on positive emotions, Dementors can perform their last and most dangerous ability: the Dementor's Kiss, in which a Dementor latches its mouth onto a victim's and sucks out the person's soul. [2] The victim is left as an empty shell, incapable of thought and with no possibility of recovery. It is believed that existing after a Dementor's Kiss is worse than death: as a person's soul is their true self, to be 'kissed' by a Dementor is to cease to exist, and yet also remain. The Ministry of Magic occasionally allowed this as a punishment, before Kingsley Shacklebolt became Minister for Magic. It is unknown what effect a Dementor's Kiss would have on a person who had split his or her soul through use of a Horcrux. It is also possible that the soul is trapped inside the Dementor, thus the victim in unable to pass on. This is probably what "worse than death" is.

The only Kiss portrayed in the books occurred in 1995; Barty Crouch Jr. who had been working in secret for Voldemort. and was restrained at Hogwarts awaiting trial. His soul was sucked out by the Dementor accompanying Cornelius Fudge as a bodyguard. [5] The unfortunate consequence of this act was that it rendered Crouch unable to testify about his master's return, allowing Voldemort almost a full year to gather strength while the Ministry continued in its denial.

Protection from Dementors

Patronus Charm

" A Patronus is a kind of positive force, and for the wizard who can conjure one, it works something like a shield, with the Dementor feeding on it, rather than him. " —Remus Lupin regarding what a Patronus is [src]

Harry Potter protecting himself and Sirius Black from Dementors, using the Patronus Charm

No one has ever demonstrated the ability to kill a Dementor, by Avada Kedavra or otherwise, implying that they can not be killed through physical means, but can only be driven away or temporarily kept at bay. One of the few ways to shield oneself from Dementors is by the very difficult Patronus Charm to fend them off. [2] The charm summons a Patronus, a magical manifestation of good will and happiness, providing varied levels of protection against the Dementors' influence, based on the caster's strength as a wizard. With sufficient ability, a single wizard can hold off dozens, if not hundreds, of Dementors with a single corporeal Patronus, as Harry Potter demonstrated during his third year at Hogwarts when he drove off a big horde of Dementors seeking to consume Hermione Granger, Sirius Black, and Harry's past self. [2]

As the Patronus is not alive, the Dementor cannot feed on it. Only when summoned by an experienced caster will the Patronus take the form of an animal significant in some way to the individual. While the lower level Patronus was more amorphous and ephemeral, corporeal Patronuses chase down Dementors and force them to flee the vicinity. [6] An incorporeal Patronus only slows a Dementor down, [2] as if the creature is walking through quicksand, and tends not to last long.

Other

Since Dementors can not properly sense the less complex thoughts and emotions of a person when he or she takes on an Animagus form, doing so allowed some, such as Sirius Black. to temporarily avoid feeling the effects of the Dementors' presence. [2] When they sensed the less-than-human thoughts of his Animagus form, the Dementors simply thought Sirius was losing his mind.

Though clearly not a common method of repelling Dementors, the enigmatic form people take after being brought back by the Resurrection Stone appears to function much like a Patronus. as the 'resurrected' forms of Sirius Black. Remus Lupin. and James and Lily Potter were able to shield Harry Potter from the Dementors that Voldemort had stationed in the Forbidden Forest in 1998.

There may be another, more common way of repelling a Dementor, aside from the Patronus Charm, as Harry Potter disagreed with Professor Snape on the best method for confronting one when it was the subject of a report in his sixth year. [3] This implies that there are, indeed, other methods.

The mood-enhancing properties of chocolate are well known in both the Muggle and wizard worlds. Chocolate is the perfect antidote for anyone who has been overcome in the presence of Dementors, which suck hope and happiness out of their surroundings. Chocolate can only be a short-term remedy, however. Finding ways to fight off Dementors — or depression — are essential if one is to become permanently happier. Excessive chocolate consumption cannot benefit either Muggle or wizard. [9]

Dark Wizards cannot produce Patronuses. However, they do not need to do so in the first place, as they are like-minded in evil. Voldemort even states that they are natural allies.

Media

Etymology

The English word dementor is used generically to refer to any evil or fearsome creature. The word ultimately derives from the Latin demens . meaning "to be insane ".

Behind the scenes

A Dementor in LEGO form

J. K. Rowling has revealed that the inspiration for Dementors came from her bout with severe depression before her phenomenal success. [10] [11] She described the feeling as an " absence of being able to envisage that you will ever be cheerful again. The absence of hope. That very deadened feeling, which is so very different from feeling sad ." [10]

In an attempt to sabotage Harry during a Quidditch match in 1994, Draco Malfoy. Vincent Crabbe. Gregory Goyle. and Marcus Flint dressed up as Dementors to scare him. Malfoy was standing on Goyle's shoulders. Considering how tall Dementors are (they are described in Prisoner of Azkaban as reaching from the floor to the ceiling on the Hogwarts Express ), the foursome appear to account for two Dementors, when just a few pages earlier, Harry saw three Dementors. (Although Marcus Flint. as an older student — in his seventh year — may have been tall enough to pass as a Dementor without someone on his shoulders.) However, their attempt failed when Harry cast a Patronus Charm at them.

The Dementors in the film series seem to possess the ability to fly, whereas in the book they only seem to glide.

Because of this, the corporeal Patronus Charm in Harry Potter and the Prisoner of Azkaban seems to work differently by sending a pulse at the Dementors flying in the air rather than charging at them on the ground.

Animatronic Dementors appear in Harry Potter and the Forbidden Journey at The Wizarding World of Harry Potter. chasing the riders' flying bench through the Chamber of Secrets and around the skeleton of the Basilisk. The Dark Mark appears along with them, suggesting that a Death Eater summoned them to Hogwarts.

Dementors are often compared to the Nazgul from The Lord of the Rings . as well as the Spectres from His Dark Materials . They can also be compared to the Ra'zac of The Inheritance Cycle in that the foul breath of the Ra'zac engenders terror and lethargy in humans, though the Ra'zac cannot be repelled by a simple charm, nor are they are amortal spirits that cannot be truly destroyed.

According to W. O.M. B.A. T.. Dementors may be unknown in tropical regions.

In LEGO Harry Potter: Years 1-4 . a large Dementor serves as the final boss of Year 3.

J. K. Rowling has said that Dementors don't breed, but grow like fungi where there is decay; and are functionally immortal in terms of age. [12]

The Dementors' appearances (tall corpse-like beings wearing tattered black cloaks) is very similar to popular depictions of the Grim Reaper. Because of this, some readers assumed Dementors were incarnations of death rather than depression; the concept was very notably used in Harry Potter and the Methods of Rationality .

In Harry Potter and the Deathly Hallows: Part 2 . Aberforth repels the attacking Dementors in the Battle of Hogwarts with a wave-like Patronus. similar to the one cast by Harry in the film version of Prisoner of Azkaban .

Dementors and the Dementor's Kiss exhibit interesting parallels to Lord Voldemort and the spell that creates a Horcrux.

The Dementor's Kiss sucks out a victim's soul, while the Horcrux spell allows part of the caster's soul to be broken off. Total soul removal results in something similar to a Persistent Vegetative State and is irreversible, while creating a Horcrux reduces the humanity of the caster, both in terms of morality/behaviour and appearance (evidenced by the once handsome Tom Marvolo Riddle becoming monstrous and snake-like in appearance over time). The damage of creating a Horcrux may be undone through remorse, but the process is so painful it can be fatal.

The victim of a Dementor's Kiss cannot become a ghost. since the soul has been lost. Presumably, the victim also cannot enter the afterlife, or possibly even Limbo. Similarly, the maker of a Horcrux cannot die, while the Horcrux(es) is/are intact, and if an unrepentant Horcrux maker is killed, he or she is trapped in Limbo and cannot enter the afterlife.

In Harry Potter and the Prisoner of Azkaban . Lupin states "the only people that know what's under a Dementor's hood are in no state to tell us (being soulless)" but from the 5th movie and onward, they are shown without any hood at all. This is likely due to change of directors.

A species of wasp. Ampulex dementor . is named after the Dementor. This name was chosen to reflect the fact that the wasp uses a toxin to neutralise the neural behaviour of cockroaches and make them docile, as if they had had their souls sucked out. [13]

For the films they initially created puppets for the Dementors which were operated underwater to give them their floating on air effect. Ultimately these did not appear in the final edit and CGI Dementors were used instead.

Foreign words for Dementor

Albanian . "Marroses"

Bulgarian: "Диментор"

Catalan . "Dementor" (pronounced duh-MEN-toor)

Chinese .

Taiwan . ??? - cuikuangmo - "drive-mad devil/demon"

Mainland . ??? - shehunguai - "suck-soul devil/monster"

Czech . "mozkomor" - "plague of the brain"

Danish: "Dementor"

Dutch: "Dementor"

Finnish . "ankeuttaja", from "ankeus" - "drearyness"

French . "detraqueur" - "that which makes (things) go wrong or break down"

German . "Dementor"

Georgian . ????????? (???????????); (pronounced dementori, plural: dementorebi)

Greek: "??????????" (pronounced "Parafronas") - from Greek "????????" meaning "mentally ill".

Hebrew . "??????" - from "????" ("prison warden") and "????" ("destructive")

Hindi (India): ??????? ( damapishacha or dampishach ) - from Sanskrit dama = "house" and pishacha (a type of Hindu demon: see pishacha ).

Hungarian: "Dementor"

Icelandic . "Vitsuga" - The one who sucks out your mind, or sense of anything.

Indonesian . "iblis" - "demon of death and happiness remover"; see wikipedia:Iblis

Italian . "dissennatore" - "he who takes sanity away", from senno meaning 'mental sanity'

Japanese .

?????? - dimenta

??? - " kyukonki " - suck-soul ghost/demon (modeled after East Asian words for vampires)

Lithuanian . "Psichas" - Mental/Psycho

Latvian: Atpratotajs

Macedonian: Дементор

Norwegian . "Desperant" - One that brings out despair

Persian: "?????? ???" - Maddening

Polish: "Dementor"

Portuguese .

Brazilian . "Dementador"

European . "Dementor" (plural: "Dementores")

Romanian . "Dementor"

Russian: "Дементор" (plural: Дементоры)

Slovak . "Dementor"

Slovenian: "Morakvar"

Spanish . "Dementor"

Swedish: "Dementor"

Thai . "????????????" - "Poo-khum-win-yarn" - Soul Warden

Turkish . "Ruh Emici" - "soul-suckers"

Ukrainian: " Дементор" (plural: Дементори)

Vietnamese . "giam ng?c Azkaban" - "prison guards of Azkaban"

Appearances

The Harry Potter Wiki has 56 images related to Dementor .

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Some medicines may interact with Aciclovir. Tell your health care provider if you are taking any other medicine, especially any of the following:

Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aciclovir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Aciclovir may cause drowsiness, dizziness, vision changes, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Aciclovir with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Aciclovir may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit down or stand up slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Aciclovir may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Aciclovir. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Aciclovir is not a cure for genital herpes and will not prevent the virus from spreading. Avoid sexual intercourse when sores are present to prevent infecting your partner. You can also be contagious and spread the herpes virus but not have any signs or symptoms at all. This is called asymptomatic viral shedding.

Lab tests, including kidney function and serum urea nitrogen (BUN), may be performed while you use Aciclovir. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Aciclovir with caution in the elderly; they may be more sensitive to its effects, especially confusion, drowsiness, or hallucinations.

Aciclovir is not recommended for use in children younger than 2 years old as safety and effectiveness for children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Aciclovir while you are pregnant. Aciclovir is found in breast milk. If you are or will be breast-feeding while you use Aciclovir, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; general body discomfort; headache; nausea/vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); aggressive behavior; blood in the urine; confusion; decreased consciousness; decreased urination; hallucinations; lower back pain; mental or mood changes; red, swollen, blistered, or peeling skin; seizures; unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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New Page 1, Nepatic

What are the common liver masses?

Malignant liver tumors

Metastatic tumors

Hepatocellular carcinoma

Cholangiocarcinoma

Benign focal liver lesions

Cysts

congenital

parasitic - echinococcal

Cavernous hemangiomas

Focal nodular hyperplasia

Hepatic adenomas

Abscesses

What are the useful imaging modalities to investigate liver masses?

Utility of each procedure - Indicate when you would select each procedure.

CT scan

Is the best imaging modality to evaluate liver masses. It can identify other intra-abdominal masses and vascular involvement, i. e. thrombosis, etc.

CT angiography shows early enhancement of tumor in arterial phase.

Ultrasound

Is most useful intra-operatively, during which the transducer is placed directly upon the liver surface to recognize liver lesions.

Transabdominal ultrasonography is inferior in sensitivity for liver masses to CT or MRI.

Doppler is helpful to demonstrate vascularity of lesions.

Carcinoma can be recognized as discrete nodules.

These typically appear as slightly hyperechoic and hypoechoic nodules.

MRI

MRI is useful for delineating vascular involvement and identifying additional intra-abdominal lesions.

Pathology of hepatoma (hepatocellular carcinoma):

Hepatoma can present as single or multiple masses or diffuse involvement.

It has a tendency to invade portal and hepatic veins.

Image Atlas of Hepatic Masses

It is divided into four lobes of unequal size and shape.

It is important to understand the complex blood flow (hepatic and portal systems) through the liver.

Parenchyma (reticuloendothelial cells) enhances with contrast uniformly with portal vein and hepatic artery branches seen through it.

In the superior slices we can see hepatic veins draining into inferior vena cava.

It is of same density as spleen.

Normal biliary ducts are not seen. They are seen only when they are dilated.

What are the imaging findings of hepatoma?

Single, multiple masses or diffuse involvement

Low attenuation lesion

Hemorrhage

Fat

Necrosis

Calcification

Hypodense capsule or rim

Enhancement seen with contrast

Can invade portal and hepatic veins

CT scan in a patient with Multicentric hepatoma

CT scan in another patient with Hepatoma

Arrowheads point to the enhancing mass. Note the lobulated margins of the liver, lower density than spleen and ascites indicating underlying cirrhosis.

Hepatoma with hemorrhage

NML is the normal liver density. White arrows point to increased density of the liver from hemorrhage (blood appears white on CT).

Black arrows point to the hepatoma. Note tiny calcification in the tumor.

Black arrows in the angiogram show the hypervascular tumor.

Hepatoma

Arrows: Tumor

Arrowheads: Tumor extends to portal vein

Portal veins dilated with intraluminal tumor. Portal veins in liver appears dark on CT because it does not enhance with contrast.

MR Imaging

Single, multiple masses or diffuse involvement

T1 weighted images

Heterogeneous, isointense to hyperintense

Hemorrhage

Fat

Necrosis

Calcification

T2 weighted images

Most hyperintense, may be isointense

Vascular invasion

Enhancement reflects vascularity and necrosis

MR shows a mass that has low signal intensity on T1 and high signal on T2.

Oval, well defined

Imperceptible or thin wall

Water density

No enhancement

Wall calcification

Septa

Well defined, anechoic

May be echogenic due to fluid content

T1 hypointense T2 marked hyperintense

May be indistinguishable from hemangioma without IV contrast

Liver Cyst

CT with IV contrast

Large cyst right lobe of liver.

Oval, well defined

Imperceptible or thin wall

Water density

Liver Cyst

An echoic mass: Cyst

Sharp posterior wall

Good posterior enhancement of echoes

Ultrasound features that are specific for a cyst include an echolucent mass with a well-defined thin wall and increased through-transmission.

Lesions which show these features need no further evaluation.

Small (< 1.0 cm) cysts may be difficult to characterize with confidence.

What are the imaging findings of liver metastases?

Single lesion

Multiple hypodense lesions

Hypervascular lesions

Liver metastasis

Multiple hypodense lesions seen in the liver with no significant contrast enhancement.

Primary: Colon carcinoma

Discuss the utility of imaging procedures for detection of liver metastases.

CT scan is the imaging procedure of choice to evaluate liver for metastases.

Hypervascular metastases may be difficult to detect on CT scans performed with a single phase technique. Triphasic scans should be done.

CT arterial portography can improve sensitivity for metastatic lesions, albeit with lower specificity.

Is most useful intraoperatively, during which the transducer is placed directly upon the liver surface to recognize liver metastases.

Transabdominal ultrasonography is inferior in sensitivity for liver masses to CT or MRI.

Aceptin-R, Aceptin-R

Ranitidine is used for treating certain conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It is also used to treat ulcers of the small intestine that have not responded to other treatment. It may be used as a short-term alternative to oral ranitidine, in patients who are not able to take medicine by mouth. Ranitidine is an H 2 - receptor blocker. It works by blocking the action of histamine in the stomach. This reduces the amount of acid the stomach makes. Reducing stomach acid helps to reduce heartburn, heal irritation of the esophagus, and heal ulcers of the stomach or intestines.

Use Ranitidine as directed by your doctor.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

You may take antacids while you are using Ranitidine if you are directed to do so by your doctor.

Continue to use Ranitidine even if you feel well. Do not miss any dose.

If you miss a dose of Ranitidine, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ranitidine.

Store Ranitidine between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ranitidine out of the reach of children and away from pets.

Do NOT use Ranitidine if:

you are allergic to any ingredient in Ranitidine

you have a history of the blood disease porphyria

you are taking dasatinib.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Ranitidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems

if you have abnormal blood electrolyte levels or a history of irregular heartbeat.

Some medicines may interact with Ranitidine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Certain benzodiazepines (eg, midazolam, triazolam), glipizide, procainamide, or warfarin because the risk of their side effects may be increased by Ranitidine

Dasatinib, delavirdine, gefitinib, certain HIV protease inhibitors (eg, atazanavir), itraconazole, or ketoconazole because their effectiveness may be decreased by Ranitidine.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ranitidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Ranitidine may rarely cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ranitidine with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Ranitidine may interfere with certain lab tests, including urine protein tests. Be sure your doctor and lab personnel know you are taking Ranitidine.

Lab tests, including liver function, may be performed while you use Ranitidine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Ranitidine should be used with extreme caution in children younger than 1 month old; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ranitidine while you are pregnant. Ranitidine is found in breast milk. Do not breastfeed while taking Ranitidine.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; headache; nausea; stomach upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); change in the amount of urine produced; confusion; dark urine; depression; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; severe or persistent headache or stomach pain; unusual bruising or bleeding; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Gastrointestinal - Aceptin-r (Brand name: ranitidine)

Ranitidine is used for treating certain conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It is also used to treat ulcers of the small intestine that have not responded to other treatment. It may be used as a short-term alternative to oral ranitidine, in patients who are not able to take medicine by mouth. Ranitidine is an H 2 - receptor blocker. It works by blocking the action of histamine in the stomach. This reduces the amount of acid the stomach makes. Reducing stomach acid helps to reduce heartburn, heal irritation of the esophagus, and heal ulcers of the stomach or intestines.

Use Ranitidine as directed by your doctor.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

You may take antacids while you are using Ranitidine if you are directed to do so by your doctor.

Continue to use Ranitidine even if you feel well. Do not miss any dose.

If you miss a dose of Ranitidine, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ranitidine.

Store Ranitidine between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ranitidine out of the reach of children and away from pets.

Do NOT use Ranitidine if:

you are allergic to any ingredient in Ranitidine

you have a history of the blood disease porphyria

you are taking dasatinib.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Ranitidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems

if you have abnormal blood electrolyte levels or a history of irregular heartbeat.

Some medicines may interact with Ranitidine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Certain benzodiazepines (eg, midazolam, triazolam), glipizide, procainamide, or warfarin because the risk of their side effects may be increased by Ranitidine

Dasatinib, delavirdine, gefitinib, certain HIV protease inhibitors (eg, atazanavir), itraconazole, or ketoconazole because their effectiveness may be decreased by Ranitidine.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ranitidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Ranitidine may rarely cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ranitidine with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Ranitidine may interfere with certain lab tests, including urine protein tests. Be sure your doctor and lab personnel know you are taking Ranitidine.

Lab tests, including liver function, may be performed while you use Ranitidine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Ranitidine should be used with extreme caution in children younger than 1 month old; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ranitidine while you are pregnant. Ranitidine is found in breast milk. Do not breastfeed while taking Ranitidine.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; headache; nausea; stomach upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); change in the amount of urine produced; confusion; dark urine; depression; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; severe or persistent headache or stomach pain; unusual bruising or bleeding; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Concrete & Masonry, Sand Springs, OK

R. W. Davis Company, is a locally owned and operated company with over 25 years of industry experience. We are a full service home improvement contracting company and specialize in a variety of home improvement projects to include concrete work, doors, and windows. We pride ourselves on the quality of our work as well as our commitment to outstanding results. We look forward to building lasting relationships with our clients and guarantee your satisfaction!

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Door Installation, Replacement, and Repair

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Residential

Commercial

Accepting

Lidocaine - National Library Of Medicine - Pubmed Health, Lignocaine

Lidocaine

Evidence reviews

Lidocaine is the drug of choice for inducing spinal anaesthesia in ambulatory surgery because of its rapid onset of action, intense nerve blockade, and short duration of action. The possible side effects of spinal anaesthesia in adults, which develop after recovery, are backache, post?dural puncture headache, and transient neurologic symptoms that are characterized by slight to severe pain in the buttocks and legs. TNS symptoms develop within a few hours and up to 24 hours after anaesthesia. They last, in most cases, up to two days. The present review shows that lidocaine is more likely to cause transient neurologic symptoms than bupivacaine, prilocaine, and procaine. However, these drugs produce prolonged local anaesthetic effects and therefore are not desirable for ambulatory patients. It is possible that the reintroduction of 2?chloroprocaine will solve this lack of a suitable intrathecal local anaesthetic; confirmatory studies are needed.

Joint dislocation refers to displacement of the bones which form a joint away from their anatomical position. The shoulder is the most commonly dislocated joint managed in the emergency department (ED). When the dislocation occurs towards the front of the body, this is known as an anterior shoulder dislocation. It is called an acute anterior shoulder dislocation if the dislocation occurred with the previous 48 hours. Manually manipulating the displaced bones back to their normal position (manual reduction) is very painful. To allow for manual reduction, pain relief can be achieved either by injecting a local anaesthetic drug (for example, lignocaine) into the dislocated shoulder joint (intra?articular lignocaine injection); or by injecting a pain killer with or without a sedative directly into the bloodstream through a vein (intravenous analgesia). The review authors searched the medical literature and identified five studies comparing these two methods. The studies included 211 patients with acute anterior shoulder dislocation; 113 patients underwent intra?articular lignocaine injection and 98 underwent intravenous analgesia with sedation. The review found that there may be no difference in the immediate success of manual reduction of the dislocated shoulder between patients receiving intra?articular lignocaine injection and those who received intravenous analgesia and sedation. However, intra?articular lignocaine injection may be associated with fewer side effects and a shorter stay in the emergency department before discharge from hospital. Compared with intravenous analgesia and sedation, intra?articular lignocaine may also be cheaper. However, the relatively small number of studies included in the review and the relatively small number of patients in each study means that the results of the review preclude definitive conclusions regarding the superiority of either method.

Burns are very common and sometimes fatal, and the pain associated with such injury is one of the most difficult types to relieve. The use of high?dose opioid medications like morphine is common, but side effects are encountered. Alternative agents such as lidocaine, an anaesthetic, have been proposed. This is an update of the review of the same name first published in 2007.

Summaries for consumers

Lidocaine is the drug of choice for inducing spinal anaesthesia in ambulatory surgery because of its rapid onset of action, intense nerve blockade, and short duration of action. The possible side effects of spinal anaesthesia in adults, which develop after recovery, are backache, post?dural puncture headache, and transient neurologic symptoms that are characterized by slight to severe pain in the buttocks and legs. TNS symptoms develop within a few hours and up to 24 hours after anaesthesia. They last, in most cases, up to two days. The present review shows that lidocaine is more likely to cause transient neurologic symptoms than bupivacaine, prilocaine, and procaine. However, these drugs produce prolonged local anaesthetic effects and therefore are not desirable for ambulatory patients. It is possible that the reintroduction of 2?chloroprocaine will solve this lack of a suitable intrathecal local anaesthetic; confirmatory studies are needed.

Joint dislocation refers to displacement of the bones which form a joint away from their anatomical position. The shoulder is the most commonly dislocated joint managed in the emergency department (ED). When the dislocation occurs towards the front of the body, this is known as an anterior shoulder dislocation. It is called an acute anterior shoulder dislocation if the dislocation occurred with the previous 48 hours. Manually manipulating the displaced bones back to their normal position (manual reduction) is very painful. To allow for manual reduction, pain relief can be achieved either by injecting a local anaesthetic drug (for example, lignocaine) into the dislocated shoulder joint (intra?articular lignocaine injection); or by injecting a pain killer with or without a sedative directly into the bloodstream through a vein (intravenous analgesia). The review authors searched the medical literature and identified five studies comparing these two methods. The studies included 211 patients with acute anterior shoulder dislocation; 113 patients underwent intra?articular lignocaine injection and 98 underwent intravenous analgesia with sedation. The review found that there may be no difference in the immediate success of manual reduction of the dislocated shoulder between patients receiving intra?articular lignocaine injection and those who received intravenous analgesia and sedation. However, intra?articular lignocaine injection may be associated with fewer side effects and a shorter stay in the emergency department before discharge from hospital. Compared with intravenous analgesia and sedation, intra?articular lignocaine may also be cheaper. However, the relatively small number of studies included in the review and the relatively small number of patients in each study means that the results of the review preclude definitive conclusions regarding the superiority of either method.

Burns are very common and sometimes fatal, and the pain associated with such injury is one of the most difficult types to relieve. The use of high?dose opioid medications like morphine is common, but side effects are encountered. Alternative agents such as lidocaine, an anaesthetic, have been proposed. This is an update of the review of the same name first published in 2007.

Buy Roxithromycin - Online Without Prescriptions, Infectoroxit

Roxithromycin

Roxithromycin is a macrolide antibiotic. Roxithromycin is very similar in composition, chemical structure (semi-synthetic) and mechanism of action to erythromycin, azithromycin, or clarithromycin. Antibiotics such as Roxithromycin can often be prescribed for several different infections, including some STDs, upper and lower respiratory tract infections and asthma, gum infections like gingivitis, and bacterial infections associated with stomach and intestinal ulcers. Roxithromycin is absorbed well into the gastro-intestinal tract, with few side effects, and actively responds to the presence of cryptosporidium, pneumocystis carinii (PCP), toxoplasma gondii, and Mycobacterium Avium (MAC).

Use Roxithromycin as directed by your doctor.

Take Roxithromycin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

To clear up your infection completely, take Roxithromycin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Roxithromycin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Roxithromycin.

Store Roxithromycin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Roxithromycin out of the reach of children and away from pets.

Do NOT use Roxithromycin if:

you are allergic to any ingredient in Roxithromycin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Roxithromycin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances.

Ask your health care provider if Roxithromycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Be sure to use Roxithromycin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Roxithromycin only works against bacteria; it does not treat viral infections.

Long-term or repeated use of Roxithromycin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Use Roxithromycin with caution in the elderly; they may be more sensitive to the effects of Roxithromycin.

Use Roxithromycin with extreme caution in children younger 10 years who have diarrhea or an infection of the stomach or bowel.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Roxithromycin while you are pregnant. Roxithromycin is found in breast milk. If you are or will be breast-feeding while you use Roxithromycin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Nausea, vomiting, indigestion, cramps.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; dark urine; decreased urination; fever, chills, or sore throat; joint pain; red, swollen, or blistered skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; unusual tiredness or weakness; vaginal itching, odor, or discharge; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Salon Cerchio - 11 Reviews - Hair Salons - 11113 Main St, Bellevue, Wa - Phone Number, Cerchio

Salon Cerchio

Ok, so I just came home from getting my hair done by Jerre at this salon, and I have to say, in all honesty, that this is the best damn haircut and color I've ever had in my whole life!

First of all, this is a lovely, homey salon that used to be an art gallery. They still incorporate art pieces on the walls, and there's a fireplace against a wall. Hardwood floors. Rooms, ante rooms and a deck through some French doors. The staff couldn't be nicer and I felt at home here immediately.

Jerre is a veritable artist. I've never known a hair stylist like her: she truly takes the time to analyze your hair and listen to you, what look you're hoping to achieve. I've never had a stylist take so much time to work with you so you get the results you want. And, my god, what a fabulous new hair style and color I got! I feel like a totally different person.

I really like how Jerre said I could return within 2 weeks if I wasn't thrilled with my color and/or hair cut and she will change it. But I AM thrilled, so it's all moot. And how cool, to be guided outside (on the deck) to see how the color was in natural light.

The color is phenomenal. Three colors were used (a darker under-color for depth, and a top color with lighter highlights). The cut is phenomenal. My fine hair looks and feels a ton fuller, and thicker, and healthier. I'm being told I look a lot younger. Who doesn't want to hear that.

Was this review …?

I used a Groupon for Ginette Thomas. I had a cut, highlights, shampoo and blow dry. I was a bit leery about using a Groupon for hair services. The results were satisfactory. The experience was not. The haircut turned out great, highlights were put on a bit sloppy and I have a huge streak on one side of my head. The appointment started 20 minutes late. No apologies were given. She checked her haircut work rather thoroughly. I found her attitude a bit brusque. When I was leaving she shouted a rude remark about "stay on the road". I did tip on the regular price. Maybe this is why a stylist that obviously has some talent has to have a Groupon to attract clients.

Was this review …?

I absolutely love Tracy! I moved here from Texas and went through hair dressers very quickly, that is until I found Tracy. I even stayed with her after I moved to West Seattle. For those of you who have made the trip, you know Tracy is something special. She is the only hairdresser has done what I asked for and after my first visit I knew I could trust her with my hair. Now I go in, tell her what I like and she puts her expertise to work and I have yet to be disappointed! She also has the sweetest personality and my visits always go quickly. I cannot recommend her enough!

Was this review …?

My first facial experience at Unis Spa inside Salon Cerchio can be summed up in two words: relaxation and satisfaction. I'd been cautious about getting facials before because my skin is rather on the sensitive side and can get irritated easily. However, after getting a facial done at Unis Spa (recommended by my cousin) I see how it can be addicting now! Alisha, the esthetician, gave me a couple different oxygen treatments and it felt really refreshing. Afterwards, my face looked brighter and my skin hasn't been as dry as it used to be in winter time.

Was this review …?

In regards to "Elle - A clinical day spa" located inside the Salon Cerchio: Coemala, the Esthetician I was booked with was 27 minutes late for the appointment. Just as I was about to walk out, she pulled up. I assume they would have made me forfeit my appointment with a fee if I had shown up that late. If that wasn't bad enough, she never once said "I'm sorry". So unprofessional and disrespectful! The entire experience/product was substandard. I will not go back and would not recommend it to anyone.

Was this review …?

Today is my second time going back and having Ginnette Thomas as my hair stylist! I had received recommendations for Salon Cerchio through a friend and finally decided to give it a go! The first time she hi-lighted and styled my hair, she just knew what color would be a perfect fit and how she styled and cut my hair was just what I needed. I have been to so many hair stylists from North Carolina to Hawaii and thought I had seen them all but nope, Ginnette is by far the best and the only stylist that just knows how to transform and just make you look and feel beautiful. Not only is she good at what she does, she is fun and super sweet too. A real down to earth lady! I will be back! Thank you Ginnette!

Was this review …?

I love Salon Cerchio and highly recommend it for it's friendly, comfortable and professional environment! The new Salon is especially inviting and worth the drive to Bellevue from Seattle. Everyone there makes you feel welcome and at home when you visit. Debi has cut my hair for 7 years now and I wouldn't trust anyone else. My naturally curly hair can be difficult to cut, but every time Debi does my hair it turns out beautifully. I especially appreciate Debi's knowledge of hair products as I tend to be very picky about I use. She has found me great organic products that contain no chemicals and work wonderfully. Most of all, Debi is a great listener and really cares about her clients!!

Was this review …?

Other Hair Salons Nearby

0.8 Miles away from Salon Cerchio

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A welcoming, fun team specializing in current trends. Redken Elite Platinum Salon offering Redken and Pureology products, Redken hair color, Chi straightening, and hair extensions. read more

We offer to you hair services, waxing, and top notch skin care services. We have a nail technician, with does gel nails, shellac and spa pedicures. Our staff members are trained, …

Specialties

We offer to you hair services, waxing, and top notch skin care services. We have a nail technician, with does gel nails, shellac and spa pedicures.

Our staff members are trained, experienced specialists who are equipped with the knowledge and skills to ensure personalized service of the highest quality.

At Salon Cerchio, our goal is to provide our clients the individual attention they deserve and ensure that they walk out of the salon looking and feeling sensational.

History

Established in 2009.

We moved into the former home and art studio of IIona Rittler.

IIona was an internationally renowned artist. At the age of 14 years old she was already an accomplished painter. She completed her formal academic and fine arts education in pre World War II Europe. She continued to study under various painters of the time in Budapest, Salzburg and Rome. She established and operated the "Exhibitors Gallery and IIona Rittler School of Fine Arts" on Main Street in Bellevue for over 50 years, actively teaching and painting until she passed away at the age of 93.

In her school, spanning over a half century, IIona and her staff taught thousands of students both professionals and amateurs of all ages, thus her passion became their passion. We hope to carry on with the same tradition as IIona, creating a warm and inviting atmosphere. We want to share with you our valued client her love of being creative by offering you a salon that is not a hair factory.

Meet the Business Owner

In 2009, Debi opened Salon Cerchio, a full-service, family concept salon. The focus of Salon Cerchio is to create a personal, tailored experience for each customer.

In 1977, Debi Pinorini launched her professional hair care career at the suggestion of her friend, Kelly Carmichael. After beauty school, she worked at the Nordstrom hair salon for the first 5 years of her career, learning the Nordstrom's approach to customer service. At that point, a great opportunity presented itself and she opened Sahaira Salon. In her 15 years at Sahaira, the salon grew to a staff of 16 people--some of whom still work with her today.

Sahaira salon was awarded the "Outstanding Volunteer Service" award from Friends of Youth, a nonprofit that supports at-risk youth, and "Salon of the Year" from Advanced Salon Products in 1995.

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Pavlich Bernie Sanders And His Leeches, Pravalich

Pavlich: Bernie Sanders and his leeches

“Sanders spent most of his life as an angry radical and agitator who never accomplished much of anything. And yet now he thinks he deserves the power to run your life and your finances,” the editorial board wrote. “Friends said he was ‘always poor’ and his ‘electricity was turned off a lot.’ They described him as a slob who kept a messy apartment — and this is what his friends had to say about him. The only thing he was good at was talking. non-stop. about socialism and how the rich were ripping everybody off.”

Before turning 40, Sanders lived in a rundown shack with a dirt floor, not because the system was against him but because he spent his time playing victim. When he failed to do any private-sector job well, including writing porn and working as a carpenter, he blamed free market straw men. He made excuses rather than learning from mistakes and bettering himself, not to mention taking responsibility for failure. When the opportunity to enter politics came along, he jumped at the chance, and he has been funded by American taxpayers for decades.

In the 1980s, a young Sanders further proved his socialist zealotry by praising breadlines as a sign of economic progress, fairness and success.

“You know, it’s funny. Sometimes American journalists talk about how bad a country is when people are lining up for food. That’s a good thing. In other countries, people don’t line up for food. The rich get the food and the poor starve to death,” Sanders said.

On the 2016 campaign trail, he’s developed a following of millennials with speeches about a “free” utopia and justice for the evil rich who are keeping poor people down.

Reality proves Sanders’s promises can never be kept and teaches us there is no such thing as “free,” period. No free college, no free housing, no free healthcare, no free cellphone service. Confiscation of 100 percent of America’s wealthiest individual assets, the “1 percent,” wouldn’t put a dent in the national debt, not to mention provide “free” everything for the other “99 percent.”

In the short term, the rich can pay taxes to provide entitlement services until the money runs out and an entire generation becomes enslaved to the government.

This is socialism, a system sold as fair. Everyone is treated equally despite how much money an individual may have in his bank account. The harsh reality is that socialism not only destroys economic freedom, it severely limits the capability of everyone to reach maximum potential. It’s a system that doesn’t provide more, but instead vastly less.

Take for example socialist Venezuela, which is currently rationing electricity and toilet paper in the name of fairness. In free market, capitalist America, the vast majority of individuals don’t have a shortage or rationing of either. Sanders isn’t offering an easier, more sustainable lifestyle. He’s offering dependence, hardship and despair.

But despite Sanders’s dishonest offerings, there is hope.

“The expanded social welfare state Sanders thinks the United States should adopt requires everyday people to pay considerably more in taxes. Yet millennials become averse to social welfare spending if they foot the bill. As they reach the threshold of earning $40,000 to $60,000 a year, the majority of millennials come to oppose income redistribution, including raising taxes to increase financial assistance to the poor,” CATO Institute research fellow Emily Ekins recently published in The Washington Post. “Similarly, a Reason-Rupe poll found that while millennials still on their parents’ health-insurance policies supported the idea of paying higher premiums to help cover the uninsured (57 percent), support flipped among millennials paying for their own health insurance with 59 percent opposed to higher premiums.”

Considering the millennial generation is the largest ever produced, I’ll hold onto that silver lining.

The definition of “free” under Sanders’s policies means taking from someone else, just as Sanders has done throughout his lifetime.

Pavlich is editor for Townhall. com and a Fox News contributor.

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