Gastroloc, Gastroloc

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Gastroloc - General Information

A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and zollinger-ellison syndrome. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-exchanging ATPase) in the proton pump of gastric parietal cells. [PubChem]

Pharmacology of Gastroloc

Gastroloc is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis, and H. pylori eradication to reduce the risk of duodenal ulcer recurrence. Gastroloc belongs to a new class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2 histamine antagonistic properties, but that suppress gastric acid secretion by specific inhibition of the H + /K + ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, omeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.

Gastroloc for patients

PRILOSEC Delayed-Release Capsules should be taken before eating. Patients should be cautioned that the PRILOSEC Delayed-Release Capsule should not be opened, chewed or crushed, and should be swallowed whole.

For patients who have difficulty swallowing capsules, the contents of a PRILOSEC Delayed-Release Capsule can be added to applesauce. One tablespoon of applesauce should be added to an empty bowl and the capsule should be opened. All of the pellets inside the capsule should be carefully emptied on the applesauce. The pellets should be mixed with the applesauce and then swallowed immediately with a glass of cool water to ensure complete swallowing of the pellets. The applesauce used should not be hot and should be soft enough to be swallowed without chewing. The pellets should not be chewed or crushed. The pellets/applesauce mixture should not be stored for future use.

Gastroloc Interactions

Omeprazole can prolong the elimination of diazepam, warfarin and phenytoin, drugs that are metabolized by oxidation in the liver. Although in normal subjects no interaction with theophylline or propranolol was found, there have been clinical reports of interaction with other drugs metabolized via the cytochrome P-450 system ( e. g., cyclosporine, disulfiram, benzodiazepines). Patients should be monitored to determine if it is necessary to adjust the dosage of these drugs when taken concomitantly with omeprazole.

Because of its profound and long lasting inhibition of gastric acid secretion, it is theoretically possible that omeprazole may interfere with absorption of drugs where gastric pH is an important determinant of their bioavailability ( e. g., ketoconazole, ampicillin esters, and iron salts). In the clinical trials, antacids were used concomitantly with the administration of omeprazole.

Combination Therapy with Clarithromycin

Co-administration of omeprazole and clarithromycin may result in increases in plasma levels of ompeprazole, clarithromycin, and 14-hydroxy-clarithromycin.

Concomitant administration of clarithromycin with cisapride, pimozide, or terfenadine is contraindicated.

There have been reports of an intereaction between erythromycin and astemizole resulting in QT prolongation and torsades de points. Concomitant administration of erythromycin and astemizole is contraindicated. Because clarithromycin is also metabolized by cytochrome P450, concomitant administration of clarithromycin with astemizole is not recommended.

Gastroloc Contraindications

Omeprazole delayed-release capsules are contraindicated in patients with known hypersensitivity to any component of the formulation.

Additional information about Gastroloc

Gastroloc Indication: For the treatment of gastroesophageal reflux disease. Mechanism Of Action: Gastroloc is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H + /K + - ATPase in the gastric parietal cell. By acting specifically on the proton pump, omeprazole blocks the final step in acid production, thus reducing gastric acidity. Drug Interactions: Alprazolam Gastroloc increases the effect of benzodiazepine Diazepam Gastroloc increases the effect of benzodiazepine Clonazepam Gastroloc increases the effect of benzodiazepine Clorazepate Gastroloc increases the effect of benzodiazepine Chlordiazepoxide Gastroloc increases the effect of benzodiazepine Estazolam Gastroloc increases the effect of benzodiazepine Flurazepam Gastroloc increases the effect of benzodiazepine Halazepam Gastroloc increases the effect of benzodiazepine Ketazolam Gastroloc increases the effect of benzodiazepine Midazolam Gastroloc increases the effect of benzodiazepine Prazepam Gastroloc increases the effect of benzodiazepine Quazepam Gastroloc increases the effect of benzodiazepine Triazolam Gastroloc increases the effect of benzodiazepine Mephenytoin Gastroloc increases the effect of hydantoin Phenytoin Gastroloc increases the effect of hydantoin Fosphenytoin Gastroloc increases the effect of hydantoin Ethotoin Gastroloc increases the effect of hydantoin Voriconazole Voriconazole increases the effect and toxicity of omeprazole St. John's Wort St. John's Wort decreases the levels/effects of omeprazole Methotrexate Gastroloc increases the levels of methotrexate Cilostazol Gastroloc increases the effect of cilostazol Atazanavir This gastric pH modifier decreases the levels/effects of atazanavir Cyclosporine Gastroloc increases the effect and toxicity of cyclosporine Dasatinib Possible decreased levels of dasatinib Enoxacin The agent decreases the absorption of enoxacin Indinavir Gastroloc decreases the absorption of indinavir Itraconazole The proton pump inhibitor decreases the absorption of the imidazole Ketoconazole The proton pump inhibitor decreases the absorption of the imidazole Disopyramide The beta-blocker increases toxicity of disopyramide Food Interactions: Avoid alcohol. Take 30-60 minutes before meals. Generic Name: Omeprazole Synonyms: Omeprazol [Inn-Spanish]; Omeprazolum [Inn-Latin]; OMEP; OMZ; OMP; Omeprazole magnesium Drug Category: Anti-Ulcer Agents; Proton-pump Inhibitors Drug Type: Small Molecule; Approved; Investigational Other Brand Names containing Omeprazole: Antra; Audazol; Aulcer; Belmazol; Ceprandal; Danlox; Demeprazol; Desec; Dizprazol; Dudencer; Elgam; Emeproton; Epirazole; Erbolin; Exter; Gasec; Gastrimut; Gastroloc; Gibancer; Indurgan; Inhibitron; Inhipump; Lensor; Logastric; Lomac; Losec; Mepral; Miol; Miracid; Mopral; Morecon; Nilsec; Nopramin; Ocid; Olexin; Omapren; Omebeta 20; Omed; Omegast; Omepral; Omeprazon; Omeprol; Omesek; Omezol; Omezolan; Omid; Omisec; Omizac; Ompanyt; Ortanol; Osiren; Ozoken; Paprazol; Parizac; Pepticum; Pepticus; Peptilcer; Prazentol; Prazidec; Prazolit; Prilosec; Procelac; Proclor; Prysma; Ramezol; Regulacid; Result; Sanamidol; Secrepina; Tedec Ulceral; Ulceral; Ulcesep; Ulcometion; Ulcozol; Ulcsep; Ulsen; Ultop; Ulzol; Victrix; Zefxon; Zegerid; Zepral; Zimor; Zoltum; Absorption: Absorption is rapid, absolute bioavailability (compared to intravenous administration) is about 30-40% at doses of 20-40 mg. Toxicity (Overdose): Symptoms of overdose include confusion, drowsiness, blurred vision, tachycardia, nausea, diaphoresis, flushing, headache. and dry mouth. Protein Binding: 95% Biotransformation: Hepatic. Half Life: 0.5-1 hour Dosage Forms of Gastroloc: Capsule, delayed release Oral Tablet, delayed release Oral Capsule Oral Chemical IUPAC Name: 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole Chemical Formula: C17H19N3O3S Omeprazole on Wikipedia: http://en. wikipedia. org/wiki/Omeprazole Organisms Affected: Humans and other mammals


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