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LIPAGLYN 4 mg. Pack of 10 Tablets

Side Effects of Tixylix 60ml Linctus:

CNS depression, paradoxical excitation in childn, dryness of mouth, blurring of vision, retention of urine, constipation, glaucoma, tachycardia, headache, hypotension, tinnitus.

Drug Interactions of Tixylix 60ml Linctus:

Masks ototoxicity of aminoglycoside antibiotics. May enhance the sedative effects of CNS depressants like alcohol, hypnotics, barbiturates and opioids. Potentially Fatal: Ventricular arrhythmias when used with drugs that prolong QT interval.

Contraindications of Tixylix 60ml Linctus:

Hypersensitivity, coma, porphyria, cardiac disease, hypokalaemia, intra-arterial or SC inj, neonates and young children, pregnancy, lactation.

Mechanism of Action of Tixylix 60ml Linctus:

Promethazine, a phenothiazine derivative, blocks postsynaptic dopaminergic receptors in the brain and has a strong ?-adrenergic blocking effect. It competitively binds to H1-receptors. Absorption: Well absorbed (Oral, IM); peak plasma concentrations after 2-3 hr. Distribution: Widely distributed: Brain, crosses the placenta, enters breast milk. Protein-binding: 76-93%. Metabolism: Extensive hepatic 1st-pass metabolism; converted to promethazine sulfoxide, N-desmethylpromethazine. Excretion: Via urine and bile (as metabolites); 5-14 hr (elimination half-life).

Special Precautions for Tixylix 60ml Linctus:

Elderly, glaucoma, epilepsy, CVS disease, impaired liver function, asthma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction. May cause drowsiness. For parenteral admin: Drug must be administered carefully and slowly; incorrect admin can lead to severe tissue injury.

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