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Discotrine

Ortostatisk hypotension. Synkope.

Meget sj?ldne ( 2 /24 timer.

Ved applikation pa intakt hud af 1 depotplaster 10 mg/24 timer nas steady state-plasmakoncentration pa ca. 0,2 nanogram/ml efter ca. 2 timer.

Denne koncentration opretholdes, indtil plastret fjernes inden for 24 timer.

Glycerylnitratabsorptionen forts?tter efter fjernelsen af plastret, idet den i hudlaget bundne m?ngde frigores, og det vil derfor vare ca. 1 time, for plasmakoncentrationen er halveret.

Plasmahalveringstid for glycerylnitrat er ca. 5 minutter.

Egenskaber, handtering og holdbarhed

Plastrene er transparente og ovale (absorptionsareal 13,3 cm 2 ).

Bem?rk: Det brugte plaster indeholder stadig aktivt l?gemiddel og skal derfor kasseres pa samme made som anden medicin.