Cipronil, Cipronil


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Ciprinol

Ciprofloxacin is reported as an ingredient of Ciprinol in the following countries:

Ciprofloxacin hydrochloride monohydrate (a derivative of Ciprofloxacin) is reported as an ingredient of Ciprinol in the following countries:

Ciprofloxacin lactate (a derivative of Ciprofloxacin) is reported as an ingredient of Ciprinol in the following countries:

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Product Details

Cipronil ® Description Cipronil®, containing Ciprofloxacin is a synthetic quinolones anti-infective agent. Ciprofloxacin has broad spectrum of activity. It is active against most gram-negative aerobic bacteria including Enterobacteriaceae and Pseudomonas aeruginosa. Ciprofloxacin is also active against gram-positive aerobic bacteria including penicillinase producing, non-penicillinase producing, and methicilline-resistant staphylococci, although many strains of streptococci are relatively resistant to the drug. The bactericidal action of Ciprofloxacin results from interference with the enzyme DNA gyrase needed for the synthesis of bacterial DNA.

Following oral administration it is absorbed from the G. I. tract rapidly and well. It is widely distributed into body tissues and fluids. The half-life is about 3.5 hours. About 30% to 50% of an oral dose of ciprofloxacin is excreted in the urine within 24 hours as unchanged drug and biologically active metabolites. Presentation Cipronil® 500: Each film-coated tablet contains Ciprofloxacin 500 mg as Ciprofloxacin Hydrochloride USP. Cipronil® 750: Each film-coated tablet contains Ciprofloxacin 750 mg as Ciprofloxacin Hydrochloride USP. Cipronil® PFS. When reconstitute each 5ml contain Ciprofloxacin 250mg. Indications Cipronil® is used in the treatment of infections caused by sensitive organisms. Respiratory tract infections: lobar and bronchopneumonia, acute & chronic bronchitis, cystic fibrosis, bronchiectasis. Ear, nose and throat infections: otitis media, sinusitis, mastoiditis, and tonsilitis. Skin and soft tissue infection: infection of wound, abscess, cellulitis, furunculosis, impetigo, and infected burn. Acute systemic infections: septicemia peritonitis. Gastrointestinal tract infections: enteric fever, diarrhoea due to infection, bacillary dysentery, enteritis, peritonitis. Eye infection: bacterial conjunctivitis. Infections of bone joints: osteomyelitis, septic arthritis. Gonorrhoea: urethral, rectal and pharyngeal gonorrhoea caused by beta lactamase producing organisms.

Dosage and administration The dose of Cipronil® is determined according to the type of infection, severity of the pathogen and age, weight and effectiveness of the kidney of the patient. General dosage for adults: 250-750 mg 12 hourly. For the treatment of gonorrhoea: 500 mg as a single dose. Depending on the severity of urinary tract infection: 250-500 mg 12 hourly. Depending on the severity of respiratory tract infection: 250-500 mg 12 hourly according to the direction of the physician. Serious skin and soft tissue infections and osteomyelitis: Caused by Gram-negative bacteria recommended dose 500-750 mg twice daily. For serious skin and soft tissue infections, the duration of treatment is 5 to 10 days. For osteomyelitis, the usual duration of treatment is 4 to 6 weeks or longer. Impaired renal function: Dosage adjustments are required with severe renal impairment (serum creatinine > 265 micromole/l or creatinine 51 kg) 10 to 21 days Twice daily Typhoid fever 12mg/kg 10 days Twice daily Invasive diarrhea 10mg/kg 3 days Twice daily Shigellosis 10mg/kg 5 days Twice daily Inhalational anthrax (post exposure) 15mg/kg (maximum 500mg per dose) 60 days Twice daily

Contraindications, Side effects, Warnings etc: Contraindication Ciprofloxacin should not be given to patients with a history of hypersensivity to Ciprofloxacin and to other quinolones and to children and in pregnant women. Side effects Nausea, vomiting, abdominal pain, diarrhoea, headache, dizziness, rash, itching, fatigue, joint pain, mild light sensitivity, crystalluria, temporary disturbance of liver enzymes, myalgia, etc. Pregnancy and lactating mother Ciprofloxacin cannot be used during pregnancy or for lactating mothers. Drug interaction Magnesium hydroxide or aluminium hydroxide containing antacids decreases the absorption of Ciprofloxacin. The use of Ciprofloxacin with theophylline may increase the plasma concentration of theophylline. Precaution It should be used with caution in patients with suspected or known CNS disorders such as arteriosclerosis or epilepsy or other factors which predispose to seizures and convulsions. It is excreted in human milk and because of the potential for serious adverse reaction to Ciprofloxacin in infants, it may be used after taking into account the importance of the drug to the mother. Patients taking Ciprofloxacin should drink a large amount of water or other liquids to prevent excessive alkalinity in urine. Pharmaceuticals Precautions Cipronil® should be stored in a cool and dry place, away from light. Keep out of reach of children.

Packaging quantity Cipronil® 500. Each box containing 30 tablets in alu-alu pack. Cipronil® 750. Each box containing 12 tablets in alu-alu pack. Cipronil® PFS :Ciprofloxacin 250mg/5ml Pellets for 60ml suspension.

Ciplox is used to treat different types of bacterial infections. It may also be used to prevent or slow anthrax after exposure.

Take Cipro exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take Cipro with a full glass of water (8 ounces). Drink several extra glasses of fluid each day while you are taking this medicine. Cipro may be taken with or without food, but take it at the same time each day. Shake the oral suspension (liquid) for at least 15 seconds just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

When taking the Cipro oral liquid, swallow it without chewing the medicine beads you may notice in the liquid.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time. Do not take Cipro with dairy products such as milk or yogurt, or with calcium-fortified juice. You may eat or drink these products as part of a regular meal, but do not use them alone when taking Cipro. They could make the medication less effective.

Take Cipro for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cipro will not treat a viral infection such as the common cold or flu.

Store Cipro at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

If you missed a dose - take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Take exactly as prescribed by your Health Provider.

Store this medicine at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

You should not use Ciplox if you are taking tizanidine (Zanaflex), if you have a history of myasthenia gravis, or if you are allergic to ciprofloxacin or similar antibiotics such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), and others.

Before taking Ciplox, tell your doctor if you have a heart rhythm disorder, kidney or liver disease, joint problems, diabetes, muscle weakness or trouble breathing, a condition called pseudotumor cerebri, a history of seizures, a history of head injury or brain tumor, low levels of potassium in your blood, a personal or family history of Long QT syndrome, or if you have ever had an allergic reaction to an antibiotic.

Do not take Ciplox with dairy products such as milk or yogurt, or with calcium-fortified juice. Avoid taking antacids, vitamin or mineral supplements, sucralfate (Carafate), or didanosine (Videx) powder or chewable tablets within 6 hours before or 2 hours after you take Ciplox. Ciprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. Stop taking Ciplox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions.

You should NOT take Ciplox if:

you are also taking tizanidine (Zanaflex);

you have a history of myasthenia gravis; or

you are allergic to ciprofloxacin or similar medications such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), ofloxacin (Floxin), norfloxacin (Noroxin), and others.

To make sure you can safely take Ciplox, tell your doctor if you have any of these other conditions:

heart rhythm disorder, especially if you take quinidine (Quin-G), disopyramide (Norpace), bretylium (Bretylol), procainamide (Pronestyl, Procan SR), amiodarone (Cordarone, Pacerone), or sotalol (Betapace);

a history of head injury or brain tumor;

a condition called pseudotumor cerebri (high pressure inside the skull that may cause headaches, vision loss, or other symptoms);

a history of allergic reaction to an antibiotic;

joint problems;

kidney or liver disease;

epilepsy or seizures;

diabetes;

muscle weakness or trouble breathing;

low levels of potassium in your blood (hypokalemia); or

a personal or family history of Long QT syndrome.

FDA pregnancy category C. It is not known whether Ciplox will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using it. Ciprofloxacin passes into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Ciplox may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking Ciplox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions. Do not share Ciplox with another person (especially a child), even if they have the same symptoms you have.

Get emergency medical help if you have any of these signs of an allergic reaction to Ciplox: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Ciplox and call your doctor at once if you have a serious side effect such as:

severe dizziness, fainting, fast or pounding heartbeats;

sudden pain, snapping or popping sound, bruising, swelling, tenderness, stiffness, or loss of movement in any of your joints;

diarrhea that is watery or bloody;

confusion, hallucinations, depression, unusual thoughts or behavior;

seizure (convulsions);

severe headache, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;

pale or yellowed skin, dark colored urine, fever, weakness;

urinating less than usual or not at all;

easy bruising or bleeding;

numbness, tingling, or unusual pain anywhere in your body;

the first sign of any skin rash, no matter how mild; or

severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects:

nausea, vomiting;

dizziness or drowsiness;

blurred vision;

feeling nervous, anxious, or agitated; or

sleep problems (insomnia or nightmares).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.