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Other - Retebem (Brand name: oxytrol)

Oxytrol (oxybutynin) reduces muscle spasms of the bladder and urinary tract.

Oxytrol transdermal skin patch is used to treat symptoms of overactive bladder, such as frequent or urgent urination, incontinence (urine leakage), and increased nighttime urination.

Oxytrol may also be used for purposes not listed in this medication guide.

Use Oxytrol exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Oxytrol comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

To use the Oxytrol patch, open the sealed pouch and remove the protective liner. Apply the transdermal patch to a clean, dry area on your stomach, hip or buttock. Avoid skin that is oily, irritated, or damaged. Avoid placing the patch on a skin area that will be rubbed by a waistband or tight clothing.

Press the Oxytrol patch onto the skin and press it down firmly with your fingers. Make sure the patch is well sealed around the edges. When properly applied, the patch should stay on while swimming or bathing.

Leave the Oxytrol patch in place and wear it for 3 to 4 days. You should change the patch twice per week. Each time you apply a new patch, choose a different skin area on your stomach, hip, or buttock. Do not apply a patch to the same skin twice within one week.

Try to change your Oxytrol patch on the same two days each week (such as every Sunday and Thursday). There is a calendar printed on the package of this medication to help you establish a steady patch-changing schedule.

If the patch falls off, try sticking it back on. If it does not stay on, replace it with a new one and wear it until your next regular patch-changing day. Do not change your schedule, even if you apply a new patch to replace one that has fallen off.

After removing an Oxytrol patch, fold it in half so it sticks together and throw it away in a place where children or pets cannot get to it.

Use baby oil or mild soap and water to remove any adhesive residue that stays on your skin. Avoid using harsh soaps, alcohol, nail polish remover, or other solvents that could irritate your skin.

The Oxytrol patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging). Remove the patch before undergoing such a test. Keep the Oxytrol patch in its sealed pouch until you are ready to use it.

Adults: The usual dose is 5mg two or three times a day. This may be increased to a maximum of 5 mg four times a day to obtain a clinical response provided that the side effects are tolerated. Elderly (including frail elderly): The elimination half-life is increased in the elderly. Therefore, a dose of 2.5mg twice a day, particularly if the patient is frail, is likely to be adequate. This dose may be titrated upwards to 5mg two times a day to obtain a clinical response provided the side effects are well tolerated. Children (under 5 years of age) : Not recommended. Children (over 5 years of age) : Neurogenic bladder instability: the usual dose is 2.5mg twice a day. This dose may be titrated upwards to 5mg two or three times a day to obtain a clinical response provided the side effects are well tolerated. Nocturnal enuresis: the usual dose is 2.5mg twice a day. This dose may be titrated upwards to 5mg two or three times a day to obtain a clinical response provided the side effects are tolerated. The last dose should be given before bedtime.

Store this medicine at room temperature in a tightly-closed container, away from heat and light.

Active ingredient: Oxybutynin

Do not use Oxytrol if you are allergic to oxybutynin, or if you have:

untreated or uncontrolled glaucoma;

a blockage in your digestive tract (stomach or intestines); or

if you have decreased urination or are unable to urinate.

To make sure you can safely use Oxytrol, tell your doctor if you have any of these other conditions:

an enlarged prostate;

an intestinal disorder, such as ulcerative colitis; or

a stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion.

FDA pregnancy category B. Oxytrol is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether oxybutynin passes into breast milk or if it could harm a nursing baby. Do not use Oxytrol without telling your doctor if you are breast-feeding a baby.

Important safety information:

Before using Oxytrol, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by oxybutynin.

Tell your doctor about all other medicines you use, especially:

atropine (Donnatal, and others);

hyoscyamine (Anaspaz, Cystospaz, Levsin, and others);

an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E. E.S. EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek); or

antifungal medicine such as itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), miconazole (Oravig), or voriconazole (Vfend).

This list is not complete and other drugs may interact with Oxytrol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction to Oxytrol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Oxytrol and call your doctor at once if you have a serious side effect such as:

fever with hot, dry skin;

uneven heart rate;

pain or burning when you urinate;

urinating less than usual or not at all; or

severe itching, burning, or blistering that does not clear up within several hours after removing the skin patch.

Less serious Oxytrol side effects may include:

mild skin itching, burning, redness, or discoloration where a patch was worn;

dizziness, drowsiness, weakness;

dry eyes, blurred vision;

warmth, tingling, or redness under your skin;

nausea, vomiting, stomach pain;

constipation or diarrhea;

feeling restless; or

sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Ditropan is used for relieving symptoms of bladder problems (urinary urgency, frequency, or leakage; loss of bladder control; and painful urination) in certain patients. Ditropan is an anticholinergic. It works by relaxing muscles in the bladder.

Use Ditropan as directed by your doctor.

Take Ditropan by mouth with or without food.

Take Ditropan on a regular schedule to get the most benefit from it. Taking Ditropan at the same time each day will help you remember to take it.

Continue to take Ditropan event if you feel well. Do not miss any dose.

If you miss a dose of Ditropan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ditropan.

Store Ditropan at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tight container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ditropan out of the reach of children and away from pets.

Active Ingredient: Oxybutynin chloride.

Do NOT use Ditropan if:

you are allergic to any ingredient in Ditropan

you have bladder blockage or are unable to urinate

you have certain stomach or bowel problems (eg, blockage, decreased muscle movement) or tightening of the esophagus

you have uncontrolled narrow-angle glaucoma

you have heart problems caused by severe bleeding.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Ditropan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have trouble urinating or have very poor health

if you have a history of heart problems (eg, heart failure, fast or irregular heartbeat), high blood pressure, nervous system problems, esophagus problems (eg, reflux disease, inflammation), stomach or bowel problems (eg, colitis, inflammation), or hiatal hernia

if you have a history of liver or kidney problems, myasthenia gravis, an enlarged prostate, an overactive thyroid, or glaucoma, or if you are at risk for glaucoma.

Some medicines may interact with Ditropan. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticholinergics (eg, scopolamine), azole antifungals (eg, ketoconazole), or macrolide antibiotics (eg, erythromycin) because they may increase the risk of Ditropan's side effects

Bisphosphonates (eg, alendronate) because the risk of irritation of the esophagus may be increased

Phenothiazines (eg, chlorpromazine) because their effectiveness may be decreased by Ditropan and they may increase the risk of Ditropan's side effects.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ditropan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Ditropan may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ditropan with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Ditropan; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Ditropan may cause decreased sweating. Do not become overheated in hot weather or while you are being active; heatstroke may occur. Contact your doctor if you have been exposed to high temperatures and you develop fever; flushing; hot, dry skin; severe or persistent headache; dizziness; sudden fatigue; fast heartbeat; seizures; or fainting.

Ditropan may cause dry mouth. To help relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute. Ask your doctor or pharmacist if you have any questions.

Use Ditropan with caution in the elderly; they may be more sensitive to its effects.

Ditropan should be used with extreme caution in children younger 5 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: It is not known if Ditropan can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ditropan while you are pregnant. It is not known if Ditropan is found in breast milk. If you are or will be breast-feeding while you use Ditropan, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Blurred vision; constipation; diarrhea; dizziness; drowsiness; dry eyes, nose, skin, or mouth; headache; indigestion; nausea; stomach pain; taste changes; trouble sleeping.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficult or painful urination; fast or irregular heartbeat; fever; hallucinations; mental or mood changes (eg, agitation); seizures; swelling of the hands, ankles, or feet; vision problems.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.