Tensobon Indication, Action Of Tensobon, Interactions, Tensobon


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Tensobon [in more detail]

For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.

Tensobon Mechanism Of Action:

Tensobon competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II levels results in a decrease in blood pressure, an increase in renin activity, and stimulation of baroreceptor reflex mechanisms. Kininase II, an enzyme which degrades the vasodilator bradykinin, is identical to ACE and may also be inhibited.

Tensobon Drug Interactions:

Amiloride Increased risk of hyperkaliemia Drospirenone Increased risk of hyperkaliemia Lithium The ACE inhibitor increases serum levels of lithium Potassium Increased risk of hyperkaliemia Spironolactone Increased risk of hyperkaliemia Tizanidine Tizanidine increases the risk of hypotension with the ACE inhibitor Triamterene Increased risk of hyperkaliemia

Food Interactions:

Avoid alcohol. Avoid salt substitutes containing potassium. Take on empty stomach: 1 hour before or 2 hours after meals, food decreases absorption by 30 to 55%. Avoid natural licorice. Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.

Tensobon Chemical Formula: