Meftal (Mefenamic Acid) - United Pharmacies, Meftan

Meftal

Description

Meftal (Mefenamic Acid) is used to relieve pain. It is classified as a non-steroidal anti-inflammatory drug and it belongs to the fenamate group of NSAIDs. This medicine`s mechanism of action involves acting as an analgesic, anti-pyretic and anti-inflammatory agent, and these effects are thought to be achieved by reducing the amounts of prostaglandins (lipids which are responsible for mediating inflammation). Pain and swelling can therefore be effectively reduced. Indications include arthritis, menstrual pain (dysmenorrhea), toothaches, sore muscles, headaches, pain caused by sprains or other injuries, post surgery pain and various other disorders which have not been listed in this paragraph.

Dosage and Administration

Meftal (Mefenamic Acid) comes in 2 different strength tablets (250mg and 500mg) which are administered by mouth. The dosage will be carefully calculated by your physician and adjusted so as to suit your individual needs. Adults treating pain are sometimes directed by their physician to take 500mg by mouth, after which the dosage may be reduced to 250mg, taken at 6 hour intervals as required. Treatment will not exceed 7 days. Patients should take note of the fact that the dosage will differ for each patient according to their unique individual circumstances, and for this reason, it will be necessary to exercise strict compliance with the instructions provided by your physician at all times during treatment.

Should you notice any side effects while taking Meftal (Mefenamic Acid) tablets to treat pain or any other conditions, consult your physician. Some reactions are mild and will go away, however serious side effects are also possible. Possible reactions can include:

Anxiety

Blurry eyesight

Dizzy sensation

A buzzing sound in the ears

Perspiring more than normal

If you suffer from numbness, a weak feeling noticeable in the muscles, decreased urination, visual problems, difficulty related to balance or any other serious side effects which have not been referenced in this paragraph, you must get medical help immediately.

During treatment with Meftal (Mefenamic Acid) tablets, you should avoid the consumption of alcoholic beverages. This is because alcohol could put you at increased risk of bleeding in the stomach.

There is a possibility that the risk of severe problems relating to circulation or the heart. Patients with heart problems may be told not to take it.

If your physician decides that you need to undergo treatment with this medicine on a long term basis, regular medical checkups will be required.

Ciprinol - Drug Review Dosage, Side Effects, Action, Buy Ciprinol, Ciprinol

Ciprinol

Ciprinol review

Ciprinol is very useful in the treatment of an array of bacteria and produces less potential side effects compared to others in its class. Ciprinol is the generic name of the antibiotic that is available by the brand names Cipro. Ciprobay and Ciproxin. It is a fluoroquinolone, which acts as a bacteriocidal. Usually, bacteria in the human body are eliminated and the growth and spread is stopped through inhibitive actions. Ciprinol is used against a variety of bacterial infections including some urinary tract infections as well as the treatment and prevention of anthrax.

Ciprinol is a broad-spectrum antibiotic effective against Gram-negative and Gram-positive bacteria. It acts on enzymes to prevent bacterial cell division. Included in the bacteria that it fights are enterobacteriaceae, brucella, neisseria, campylobacter. vibrio, mycobacterium intracellulare, legionella sp. pseudomonas aeruginosa, Escherichia coli, streptococcus pneumoniae and Chlamydia. However, it is not as effective against bacteroides, entercoccus faecium, streptococcus pyogenes and ureaplasma urealyticum.

Side effects of Ciprinol, compared to other fluoroquinolones, are low in severity and frequency and usually mild to moderate. Mild to moderate side effects include nausea. vomiting. stomach pain, indigestion, cephalalgia, diarrhea. nervousness, anxiety. irritability, nightmares, insomnia. feelings of distrust, vaginal itching or discharge. These should be reported to your doctor. Serious side effects should immediately be reported to your doctor and patients should stop taking Ciprinol. Symptoms of serious side effects include rashes, hives. joint and myalgia, fainting, arrhythmia, hoarseness of voice, tingling sensation, easily fatigued, loss of appetite. fever. hallucination, depression. double vision, seizure, suicidal ideations and loss of sensitivity to touch.

Patients with hypersensitivity to quinolones and fluoroquinolones should be cautious about taking this medication. Ciprinol may interact negatively with tizanidine. anticoagulants, acetazolamide, anti-diarrheals, methotrexate and anti-inflammatory medications. Patients should tell their doctor if they are taking any herbal medications or nutritional supplements. Operating machinery and driving are discouraged until the effects of this medication are fully realized by the patient. The medication also increases skin sensitivity to ultraviolet light and sunlight but sunburns are not normal and should be reported to your doctor.

Ciprinol works by binding to the DNA gyrase enzyme. This enzyme is a type II topoisomerase and important in separating replicated DNA. The binding action causes double-stranded breaks in the chromosome of the bacteria, which stops cell division. The medication also directly acts on any existing bacteria by killing them.

In a study, 24 women ages 22 to 32 suffering from urinary tract infections were given 500 mg of Ciprinol twice daily in the form of oral pills. After 1 week, half the women were free from symptoms and by the end of the second week, all women were fully healed. Only 3 participants reported mild side effects while the others did not experience any adverse reactions.

Ciprinol is a nonprescription medication and can be bought at pharmacies and drug stores. Be sure to check the expiration date, manufacturer and location to ensure the product is still good. When buying over the internet, be sure that the source is valid by checking the address and asking for verification.

Ciprinol is taken according to the recommended dose. Never double the dose if you miss one. Each dose should be taken with a full glass of water and pills should be swallowed whole, not crushed or chewed. Patients are discouraged from taking the medication with dairy products. The medication should be stored at room temperature and kept out of children's reach at all times.

Ciprinol has the following structural formula:

• Molecular formula of ciprinol is C17H18FN3O3 • Chemical IUPAC Name is 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid • Molecular weight is 331.342 g/mol • Ciprinol available. 0.3% solution 10ml bottle, 0.3% solution 2.5ml bottle, 0.3% solution 5ml bottle, 250mg tablets, 500mg tablets, 750mg tablets

Generic name: Ciprofloxacin

Ibilex, Ibilex

Generic Name: Cephalexin Product Name: Ibilex

Indication

Cefalexin-BC is an oral antibiotic used in the treatment of the following infections when they are caused by susceptible organisms: – respiratory tract infections, including the treatment of Streptococcal throat infections to prevent rheumatic fever – bacterial sinusitis – middle ear infections – skin and skin structure infections – genitourinary tract infections, including acute prostate infection Cefalexin-BC is NOT indicated in the treatment of bacterial infections of the brain and spinal cord. In the treatment of any infection, it is important to isolate the bacteria and its antibacterial susceptibilities if possible before commencing treatment.

Action

Cephalexin is an antibiotic from the cephalosporin family, known as a first generation cephalosporin. Cephalexin can kill a number of bacteria by inhibiting production of their cell walls. It is active against Streptococci and Staphylococci, including some of those resistant to penicillins. Methicillin-resistant Staph aureus (MRSA), however, is resistant to Cephalexin as well as methicillin-type antibiotics. Cephalexin is also active against the well-known E. coli and some other bugs in its class. Cephalexin does not have activity against Enterococcus faecalis, or Pseudomonas the virulent bugs that can cause dangerous hospital infections.

Dose advice

Cefalexin-BC is for oral administration. It should not be administered in any other way. Adults – usual dose is 250mg every 6 hours or 500mg every 12hours – larger doses may be required for more serious infections or those caused by less susceptible organisms – when daily dosing is greater than 1g, doses should be divided and given more often – daily dose should not exceed 4g, if greater than this dose is required, parenteral cephalosporins should be used Children – usual dose is 25-50mg/kg daily in divided doses – the powder for suspension is recommended for use in children, as smaller doses can be measured out – treatment for otitis media may require 75-100mg/kg/day in divided doses Duration of treatment – treatment should generally continue until the symptoms of infection have been gone for at least 2 days – treatment for Streptococcal throat infection should be no shorter than 10 days to prevent rheumatic fever

Schedule

Common side effects

– diarrhoea – nausea – vomiting (less commonly)

Uncommon side effects

– stomach upset – abdominal pain – itching – dizziness – fatigue – headache – muscle aches Allergy to Cefalexin-BC may rarely occur and the following symptoms should be alerted to your doctor: – rash – hives – swelling – trouble breathing – wheezing

For further information talk to your doctor.

Kindcef, Kindcef

Kindcef

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Fredyren Txokoa Berlin, Fredyren

Puerta de Brandenburgo - Brandenburger Tor, Pariser Platz

La Puerta de Brandeburgo, antigua puerta de la ciudad y simbolo de Berlin, se encontraba situada, durante los anos de la division de la ciudad, directamente detras de la frontera, dentro del sector sovietico. La Pariser Platz formaba parte de la franja fronteriza y por lo tanto, era inaccesible para el publico.

Reichstag, Columna de la Victoria (Siegessaule) Y Monumento al Holocausto

En los alrededores de la puerta de Brandenburgo. Se pueden visitar muy bien siguiendo la ruta del Bus 100. que va desde el Zoologischer garten hasta la Alexanderplatz, pasando por la Siegessaule, Palacio Belvedere, Casa de las culturas del mundo y el Reichstag. El monumento al Holocausto lo encontramos a la izquierda de la puerta de Brandenburgo, direccion Postdamerplatz, justo enfrente del Tiergarten.

El Reichstag es desde la vuelta a la capitalidad alemana de Berlin, la sede del parlamento Aleman. Merece la pena subir a la cupula, pero cuando estuvimos no pudo ser. Para visitar la cupula habia que haber reservado por internet, en la web del Bundestag ( http://www. bundestag. de/index. jsp ). Lo que no se si es una medida provisional, o seguira en el futuro.

Columna de la Victoria o Siegessaule es la columna de la victoria de Berlin. Esta situada en medio del parque de Tiergarten -

Tambien se puede subir y desde arriba admirar una de las vistas mas espectaculares de Berlin. El Tiergarten a tus pies. En esta ocasion estaba de obras, y no pudimos subir. En el ano 90 si que pudimos subir.

Mo numento al Holocausto,“Este lugar recuerda el peor de los crimenes alemanes: el intento por exterminar a todo un pueblo”, dijo el presidente del Parlamento al inaugurarlo.

Inaugurado en diciembre de 2004, ocupa una extension de 1,9 hectareas, y esta formado por 2700 estelas de hormigon. En la parte baja hay un centro explicativo de las atrocidades de los nazis contra los judios. Te pone los pelos de punta.

Fue durante muchos anos la arteria principal de Berlin. Su nombre viene de las 4 filas de Tilos que tiene. Aunque no siempre han estado ahi. Durante el tercer Reich fue escenario de los desfiles propagandisticos de los nazis - El la Bebel platz fueron quemados mas de 30000 libros de escritores no afines al regimen - Despues de la reunificacion ha recuperado su papel principal.

Fue hasta la segunda guerra mundial, una de las plazas mas populosas de Europa. El primer semaforo fue instalado ahi(hoy hay una replica), y ya despues de la guerra se convirtio en tierra de nadie. El muro dividia en dos lo que fue la Postdamerplatz. Hoy en dia ha recuperado la actividad comercial. solo diez anos despues de la caida del muro,`pero ha perdido el encanto cultural y comercial que tenia a principios de siglo.

Llama la atencion la plaza cerrada creada por la empresa Sony. En esta plaza se lleva a cabo el Festival de Cine de Berlin. mas conocido como la Berlinale ; donde se hace entrega de los osos de oro a las mejores peliculas del festival.

Es una de la mayor concentracion de museos. Lo forman cinco museos que estan en la isla de Spree. al este de Unter den Linden -

Bode Museum

Altes Museum

Alte National galeri

Neues Museum

Pergamon Museum

La entrada a cada museo cuesta 10 euros, pero puedes sacar un bono para los cinco por 16 euros. Nosotros solo fuimos a dos, al Pergamon y al Neues. Solo ver estos dos, ya merece la pena. Para ver los cinco habriamos necesitado mas de dos dias, y no era plan.

Con la entrada puedes coger una Audio Guia, que te explica lo que vas viendo. Una autentica gozada.

Neus museum

El busto de Nefertiti, la reina de Berlin, es la mayor atraccion de este museo. Es una maravilla. Pero no es solo eso, tiene una amplisima coleccion del museo egipcio, y una coleccion de arte prehistorico e historia temprana.

Pergamon Museum

El altar de Pergamo, el Mercado de Mileto y La puerta de Isthar, tres de las maravillas que te puedes encontrar en este museo

Casi un tercio de los 160.000 residentes son inmigrantes. muchos trabajadores turcos y sus descendientes.

El muro dividio Kreutzberg en dos partes. El rio hizo de frontera entre las dos partes.

La linea 1 de metro cruza todo el barrio. Es la mas antigua, y la mas vistosa. Su trayecto por el Kreutzberg es por superficie, mas bien por altura, y sus estaciones son verdaderas joyas.

La Oranienstra?e es su arteria principal. Ahi encontramos bares. restaurantes, tiendas de libros. de ropa, hay mucha vida y ambiente. Es la antitesis de lo que es Alemania. Una gran mayoria de jovenes viven o se reunen en Kreutzberg.

Cuando se cerro el muro, en el sector americano habia tres puntos de comunicacion con el sector este, Bravo, Alpha y Charlie.

Chek point Charlie fue el mas conocido de todos, entre otras cosa gracias a que fue en este punto donde se realizaron los intercambios de espias de uno y otro lado.

Fue en este punto donde Peter Fechter intentando cruzar de un lado a otro de Berlin fue tiroteado. Murio desangrado porque ni de uno ni de otro bando hicieron nada por salvarlo, unos. los americanos, por no crear un incidente diplomatico y los del este porque no les dio la gana, El caso es que despues de fallecer aun tardaron en recoger el cadaver. En su memoria hay a unos 100 metros de Chek point Charlie, un pequeno monumento en su memoria.

Al otro lado justo donde se encontraba el cuartel de la Gestapo, esta el Museo del Horror, que no es otra cosa que los sotanos donde los nazis torturaron a miles de ciudadanos.

Justo enfrente del puesto de control (es una replica del original)de la Friedrichstrasse. esta el museo del muro. Esta vez no hemos entrado, ya lo hicimos en el ano 90.

El segmento del antiguo “muro interior” conservado tiene aprox. 1,3 km de longitud, de manera que la East Side Gallery es la “mayor galeria al aire libre del mundo”. Tambien es el segmento mas largo del muro interior que se salvo de ser derruido en Berlin y desde 1992, ha sido declarado patrimonio artistico

Gendarmenplatz, Schloss Charlottenburg y Berliner Dom

En la Gerdarmenplatz hay dos iglesias casi gemelas. Una era de los Hugonotes que se instalaron el Berlin cuando les echaron de Francia, y otra es de los catolicos alemanes. En medio esta el edificio de la Philarmonica de Berlin, (una de las tres sedes que tiene).

En la zona hay dos cerveceria bavaras, la de Agustiner que esta al lado de la iglesia francesa, y la de Lowenbrau, que esta de manzanas detras de la alemana, haciendo esquina con la Leiptzigerstrasse -

Son cervecerias tipicas de Baviera, que no tienen mucho que ver con las del norte, los precios tampoco, 1/2 litro 4,10 euros, pero aun asi merece la pena.

Detras de la iglesia hugonota, estan la galerias Lafayette.

Hasta la apertura de los museos de la museuminsel albergaba, entre otras colecciones, la dedicada al antiguo Egipto. Como no. Nefertiti era su estrella. Ahora. sin sus colecciones, juega otro papel, sus jardines junto al rio son muy visitados por los Berlineses -

En la esquina de la Luisenplatz, en la parada del bus 109, esta la Brauhaus, que es una cerveceria de fabricacion propia, Hace unos anos era basicamente una cerveceria tipica, muy diferente a como es ahora, mas seria y formal, mas como un restaurant, pero aun asi siguen teniendo una magnifica cerveza.

La catedral protestante de Berlin. Esta situada al lado de la Altes Nationalgaleri, despues del puente que une la isla Spree y Unter den Linden.

No entramos porque nos parecia un abuso cobrar 6 euros por entrar.

Company Profile For Nipress Tbk Pt, Nipress

Profile: Nipress Tbk PT (NIPS. JK)

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Trinordiol Generic Name Levonorgestrel Online, Trinordiol

Trinordiol General Information

Trinordiol - Pharmacology:

Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like levonorgestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

Trinordiol Interactions

Changes in contraceptive effectiveness associated with coadministration of other products: Contraceptive effectiveness may be reduced when hormonal contraceptives are coadministered with antibiotics, anticonvulsants, and other drugs that increase the metabolism of contraceptive steroids. This could result in unintended pregnancy or breakthrough bleeding. Examples include rifampin, rifabutin, barbiturates, primidone, phenylbutazone, phenytoin, dexamethasone, carbamazepine, felbamate, oxcarbazepine, topiramate, griseofulvin, and modafinil.

Several cases of contraceptive failure and breakthrough bleeding have been reported in the literature with concomitant administration of antibiotics such as ampicillin and other penicillins, and tetracyclines, possibly due to a decrease of enterohepatic recirculation of estrogens.

However, clinical pharmacology studies investigating drug interactions between combined oral contraceptives and these antibiotics have reported inconsistent results. Enterohepatic recirculation of estrogens may also be decreased by substances that reduce gut transit time.

Several of the anti-HIV protease inhibitors have been studied with coadministration of oral combination hormonal contraceptives; significant changes (increase and decrease) in the plasma levels of the estrogen and progestin have been noted in some cases. The safety and efficacy of oral contraceptive products may be affected with coadministration of anti-HIV protease inhibitors. Health-care professionals should refer to the label of the individual anti-HIV protease inhibitors for further drug-drug interaction information.

Herbal products containing St. Johns Wort (Hypericum perforatum) may induce hepatic enzymes (cytochrome P 450) and p-glycoprotein transporter and may reduce the effectiveness of contraceptive steroids. This may also result in breakthrough bleeding.

During concomitant use of ethinyl estradiol containing products and substances that may lead to decreased plasma steroid hormone concentrations, it is recommended that a nonhormonal backup method of birth control be used in addition to the regular intake of Lo/Ovral. If the use of a substance which leads to decreased ethinyl estradiol plasma concentrations is required for a prolonged period of time, combination oral contraceptives should not be considered the primary contraceptive.

After discontinuation of substances that may lead to decreased ethinyl estradiol plasma concentrations, use of a nonhormonal back-up method of birth control is recommended for 7 days. Longer use of a back-up method is advisable after discontinuation of substances that have led to induction of hepatic microsomal enzymes, resulting in decreased ethinyl estradiol concentrations. It may take several weeks until enzyme induction has completely subsided, depending on dosage, duration of use, and rate of elimination of the inducing substance.

Increase in plasma levels associated with coadministered drugs: Coadministration of atorvastatin and certain oral contraceptives containing ethinyl estradiol increase AUC values for ethinyl estradiol by approximately 20%. The mechanism of this interaction is unknown. Ascorbic acid and acetaminophen increase the bioavailability of ethinyl estradiol since these drugs act as competitive inhibitors for sulfation of ethinyl estradiol in the gastrointestinal wall, a known pathway of elimination for ethinyl estradiol. CYP 3A4 inhibitors such as indinavir, itraconazole, ketoconazole, fluconazole, and troleandomycin may increase plasma hormone levels. Troleandomycin may also increase the risk of intrahepatic cholestasis during coadministration with combination oral contraceptives.

Changes in plasma levels of coadministered drugs: Combination hormonal contraceptives containing some synthetic estrogens (eg, ethinyl estradiol) may inhibit the metabolism of other compounds. Increased plasma concentrations of cyclosporin, prednisolone and other corticosteroids, and theophylline have been reported with concomitant administration of oral contraceptives. Decreased plasma concentrations of acetaminophen and increased clearance of temazepam, salicylic acid, morphine, and clofibric acid, due to induction of conjugation (particularly glucuronidation), have been noted when these drugs were administered with oral contraceptives.

Interactions With Laboratory Tests - Certain endocrine and liver-function tests and blood components may be affected by oral contraceptives:

a. Increased prothrombin and factors VII, VIII, IX, and X; decreased antithrombin 3; increased norepinephrine-induced platelet aggregability.

b. Increased thyroid-binding globulin (TBG) leading to increased circulating total thyroid hormone, as measured by protein-bound iodine (PBI), T4 by column or by radioimmunoassay. Free T3 resin uptake is decreased, reflecting the elevated TBG; free T4 concentration is unaltered.

c. Other binding proteins may be elevated in serum ie, corticosteroid binding globulin (CBG), sex hormone-binding globulins (SHBG) leading to increased levels of total circulating corticosteroids and sex steroids respectively. Free or biologically active hormone concentrations are unchanged.

d. Triglycerides may be increased and levels of various other lipids and lipoproteins may be affected.

e. Glucose tolerance may be decreased.

f. Serum folate levels may be depressed by oral-contraceptive therapy. This may be of clinical significance if a woman becomes pregnant shortly after discontinuing oral contraceptives.

Trinordiol Contraindications

Combination oral contraceptives should not be used in women with any of the following conditions: - Thrombophlebitis or thromboembolic disorders - A past history of deep-vein thrombophlebitis or thromboembolic disorders - Cerebral-vascular or coronary-artery disease (current or history) - Thrombogenic valvulopathies - Thrombogenic rhythm disorders - Major surgery with prolonged immobilization - Diabetes with vascular involvement - Headaches with focal neurological symptoms - Uncontrolled hypertension Known or suspected carcinoma of the breast or personal history of breast cancer - Carcinoma of the endometrium or other known or suspected estrogen-dependent neoplasia - Undiagnosed abnormal genital bleeding - Cholestatic jaundice of pregnancy or jaundice with prior pill use - Hepatic adenomas or carcinomas, or active liver disease, as long as liver function has not returned to normal - Known or suspected pregnancy - Hypersensitivity to any of the components of Lo/Ovral

This description is suitable for active ingredient Levonorgestrel

Generic name, Overdose, Half Life Trinordiol, Food Interactions, Chemical, etc..

Trinordiol see also

Gabapentin (By Mouth) - National Library Of Medicine - Pubmed Health, Gabapentine

Gabapentin (By mouth)

Uses

Uses of This Medicine

Gabapentin is used to help control partial seizures (convulsions ) in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it.

Gabapentin is also used in adults to manage a condition called postherpetic neuralgia. which is pain that occurs after shingles .

Gabapentin works in the brain to prevent seizures and relieve pain for certain conditions in the nervous system. It is not used for routine pain caused by minor injuries or arthritis. Gabapentin is an anticonvulsant.

This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, gabapentin is used in certain patients with the following medical condition:

How To Use

Capsule, Liquid, Tablet

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. If you have epilepsy . do not allow more than 12 hours to pass between doses.

Capsule: Swallow the capsule whole with plenty of water. Do not open, crush, or chew it.

Gralise® tablet: Swallow the tablet whole. Do not crush, break, or chew it.

Neurontin® tablet: If you break a tablet into 2 pieces, use the second half as your next dose. If you don’t use it within 28 days, throw it away.

Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the Neurontin® oral liquid in the refrigerator. Do not freeze.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins. and herbal products.

Some medicines can affect how gabapentin works. Tell your doctor if you also use any of the following:

If you take an antacid, wait at least 2 hours before you take gabapentin .

Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

When Not To Use

This medicine is not right for everyone. Do not use it if you had an allergic reaction to gabapentin .

Warnings

Tell your doctor if you are pregnant or breastfeeding, or if you have kidney problems or are receiving dialysis. Tell your doctor if you have a history of depression or mental health problems.

This medicine may increase depression or thoughts of suicide. Tell your doctor right away if you start to feel more depressed or think about hurting yourself.

This medicine may cause a serious allergic reaction called multiorgan hypersensitivity, which can damage organs and be life-threatening.

Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. If you take this medicine to prevent seizures. your seizures may return or occur more often if you stop this medicine suddenly.

This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible side effects

Summary More details

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives. swelling in your face or hands. swelling or tingling in your mouth or throat. chest tightness, trouble breathing

Behavior problems, aggression, restlessness, trouble concentrating, moodiness (especially in children)

Change in how much or how often you urinate, bloody or cloudy urine ,

Chest pain, fast heartbeat, trouble breathing

Problems with coordination, shakiness, unsteadiness

Rapid weight gain, swelling in your hands. ankles. or feet

Unusual moods or behaviors, thoughts of hurting yourself, feeling depressed

If you notice these less serious side effects, talk with your doctor:

Dizziness, drowsiness, sleepiness, tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Brand names include

Active-Pac With Gabapentin, Convenience Pak, Cyclo/Gaba 10/300 Pack, FusePaq Fanatrex, Gaba-V, Gabarone, Gralise, Neurontin, Smart Rx Gaba Kit

There may be other brand names for this medicine.

The information contained in the Truven Health Analytics products is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Truven Health Analytics products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health Analytics makes no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH ANALYTICS MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE TRUVEN HEALTH ANALYTICS PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health Analytics does not assume any responsibility or risk for your use of the Truven Health Analytics products.

Portions Copyright © 2016. Truven Health Analytics, an IBM company. All rights reserved. Use of this content is subject to Truven Health Analytics' full disclaimer, available here.

Innomax America S Finest Sleep Products, Minomax

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We pride ourselves in having very friendly, knowledgeable sleep & sale consultants that provide our customers with prompt, knowledgeable assistance & enthusiastic service! When You’re Ready To Do It Right! Don’t Delay… Call or Stop In Today!

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Please feel free to use our "Live Chat" feature on our website to chat with an InnoMax Representative online or please give us a call toll free at 1-800-InnoMax (1-800-466-6629) and we’ll be happy to answer any questions that you may have.

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Cozaar (Losavik)

Cozaar is used for treating high blood pressure alone or with other medicines. It is used in certain patients to decrease the risk of stroke. It is used in certain patients to treat kidney problems caused by diabetes (diabetic nephropathy). Cozaar is an angiotensin II receptor blocker (ARB). It works by relaxing blood vessels. This helps to lower blood pressure.

Use Cozaar as directed by your doctor.

Take Cozaar by mouth with or without food.

Take Cozaar on a regular schedule to get the most benefit from it. Taking Cozaar at the same time each day will help you remember to take it.

Continue to take Cozaar even if you feel well. Do not miss any dose.

If you miss a dose of Cozaar, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Cozaar.

Store Cozaar at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cozaar out of the reach of children and away from pets.

Active Ingredient: Losartan potassium.

Do NOT use Cozaar if:

you are allergic to any ingredient in Cozaar

you are in your second or third trimester of pregnancy

the patient is a child with severe kidney problems.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Cozaar. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you are able to become pregnant

if you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an angiotensin-converting enzyme (ACE) inhibitor (eg, lisinopril)

if you have a history of heart problems (eg, heart failure), blood vessel problems, blood flow problems, liver or kidney problems, or diabetes

if you have a history of stroke or recent heart attack

if you are dehydrated or have low blood volume

if you have electrolyte problems (eg, high blood potassium levels, low blood sodium levels) or are on a low-salt (sodium) diet

if you are on dialysis or are scheduled to have major surgery.

Some medicines may interact with Cozaar. Tell your health care provider if you are taking any other medicines, especially any of the following:

Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood pressure may be increased

Potassium-sparing diuretics (eg, spironolactone, triamterene) or potassium supplements because the risk of high blood potassium levels may be increased

Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or rifampin because they may decrease Cozaar's effectiveness

Lithium because the risk of its side effects may be increased by Cozaar.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cozaar may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Cozaar may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Cozaar with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Cozaar may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Cozaar may cause a serious side effect called angioedema. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes throat, or tongue; difficulty swallowing or breathing; or hoarseness.

Cozaar may not work as well to reduce the risk of stroke in black patients. Discuss any questions or concerns with your doctor.

Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.

Check with your doctor before you use a salt substitute or a product that has potassium in it.

Tell your doctor or dentist that you take Cozaar before you receive any medical or dental care, emergency care, or surgery.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.

Diabetes patients - This may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including blood pressure, blood electrolyte levels, and heart, kidney, or liver function, may be performed while you use Cozaar. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Cozaar should not be used in children younger 6 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: Cozaar may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if Cozaar is found in breast milk. Do not breastfeed while taking Cozaar.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; dizziness; tiredness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; hoarseness); change in the amount of urine produced; chest pain; dark urine; difficulty swallowing; fast, slow, or irregular heartbeat; muscle pain or cramps; severe or persistent stomach pain (with or without nausea or vomiting); symptoms of low blood pressure (eg, fainting, severe dizziness, lightheadedness); unusual bruising or bleeding; vision changes; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Coreg (Carvedilol) Patient Information Side Effects And Drug Images At Rxlist, Cardilor

Brand Names: Coreg, Coreg CR

Generic Name: carvedilol (Pronunciation: KAR ve dil ole)

What is carvedilol (Coreg)?

Carvedilol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

Carvedilol is used to treat heart failure and hypertension (high blood pressure). It is also used after a heart attack that has caused your heart not to pump as well.

Carvedilol may also be used for purposes not listed in this medication guide.

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What are the possible side effects of carvedilol (Coreg)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

feeling like you might pass out;

slow or uneven heartbeats;

chest pain, dry cough, wheezing, chest tightness, trouble breathing;

feeling short of breath, even with mild exertion;

swelling, rapid weight gain;

numbness or cold feeling in your hands and feet;

loss of bladder control;

pale skin, feeling light-headed, rapid heart rate, trouble concentrating;

high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss); or

severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

dizziness, drowsiness;

nausea, vomiting, diarrhea;

dry eyes;

feeling weak or tired;

joint pain;

cough; or

decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Coreg (carvedilol) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about carvedilol (Coreg)?

You should not take this medication if you are allergic to carvedilol, or if you have asthma, bronchitis, emphysema, severe liver disease, or a serious heart condition such as heart block, sick sinus syndrome, or slow heart rate (unless you have a pacemaker).

If you need surgery, tell the surgeon ahead of time that you are using carvedilol. You may need to stop using the medicine for a short time.

Do not stop taking carvedilol without first talking to your doctor. Stopping suddenly may make your condition worse.

Avoid drinking alcohol within 2 hours before or after taking extended-release carvedilol (Coreg CR). Also avoid taking medicines or other products that might contain alcohol. Alcohol may cause the carvedilol in Coreg CR to be released too quickly into the body.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

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Flagyl ER (Varizil)

Flagyl ER is used for treating certain bacterial infections of the vagina (bacterial vaginosis). Flagyl ER is an oral antiprotozoal and antibacterial. It is thought to work by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria.

Use Flagyl ER as directed by your doctor.

Take Flagyl ER by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Swallow Flagyl ER whole. Do not break, crush, or chew before swallowing.

To clear up your infection completely, take Flagyl ER for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Flagyl ER, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Flagyl ER.

Store Flagyl ER at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Flagyl ER out of the reach of children and away from pets.

Active Ingredient: Metronidazole.

Do NOT use Flagyl ER if:

you are allergic to any ingredient in Flagyl ER or to another nitroimidazole (eg, tinidazole)

you are in the first trimestr of pregnancy

you are taking busulfan, an ergot alkaloid (eg, ergotamine), or you have taken disulfiram within the past 2 weeks

you are taking an HIV protease inhibitor that contains alcohol (eg, amprenavir solution); check with your pharmacist if you are unsure if the medicine contains alcohol

you drink alcohol.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Flagyl ER. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have nerve, brain, or blood problems; Crohn disease; or a history of liver problems or seizures.

Some medicines may interact with Flagyl ER. Tell your health care provider if you are taking any other medicines, especially any of the following:

Disulfiram because side effects, such as mental or mood changes, may occur

Amiodarone because the risk of irregular heartbeat may be increased

Barbiturates (eg, phenobarbital) or phenytoin because they may decrease Flagyl ER's effectiveness

Anticoagulants (eg, warfarin), busulfan, cyclosporine, ergot alkaloids (eg, ergotamine), HIV protease inhibitors containing alcohol (eg, amprenavir solution ), lithium, or macrolide immunosuppressants (eg, tacrolimus) because the risk of their side effects may be increased by Flagyl ER.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Flagyl ER may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Flagyl ER may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Flagyl ER with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not drink alcohol while you are taking Flagyl ER and for at least 3 days after the last dose.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Flagyl ER only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use Flagyl ER for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Flagyl ER may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Flagyl ER may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Flagyl ER.

Lab tests, including liver function and white blood cell counts, may be performed while you use Flagyl ER. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Flagyl ER with caution in the elderly; they may be more sensitive to its effects.

Flagyl ER should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Flagyl ER while you are pregnant. Do not use Flagyl ER in the first 3 months of pregnancy. Flagyl ER is found in breast milk. Do not breastfeed while taking Flagyl ER.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Appetite loss; constipation; diarrhea; dizziness; headache; metallic taste; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; decreased coordination; increased or decreased urination; numbness, tingling, or burning of the arms, hands, legs, or feet; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; severe or persistent dizziness or headache; sore throat, chills, or fever; speech problems; stiff neck; stomach pain or cramps; vaginal itching, odor, or discharge; vision loss or other vision changes; white patches in the mouth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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a garment worn over ordinary clothes to protect them from dirt etc . She wears an overall when cleaning the house. oorpak, oorrok ????? ??????? ????? ???????? ?????????? престилка avental pracovni plast der Overall kittel ?????. ????? ???????? guardapolvo. bata kittel ????? haalari blouse ??????-???????? ??? ?? ???? ?? ??? ??????? ????? ?? ??? ??? ??? ???? kombinezon kopeny pakaian kerja vinnusloppur; samfestingur grembiule ???? ???, ??? darbinis chalatas virsvalks baju luar overall kittel. ermeforkle kitel ??????? ??????? avental халат pracovny plast delovna halja radni mantil skydds-, stadrock ????????????????????????????? tulum ?? робочий халат; спецодяг ??? ?? ??? ????? ?? ???? ao khoac lam vi?c ??

complete, including everything. What is the overall cost of the scheme? totale ?????? ????? общ total uhrnny, celkovy Gesamt-.. samlet ????????? total uld-, kogu - ??? kokonais - total ???? ?????????: ukupan ossz - keseluruhan heildar - totale ??? ??? ???? bendras kopejs, visparejs keseluruhan totaal samlet. total-. helhets - calkowity ??? total total, global полный, общий celkovy celoten ukupan total ??????? tum. toplam ?? повний; всеосяжний ?????? t?ng th? ??

( also over all ) complete, including everything. What will the scheme cost overall? in totaal, totale ????????? ??????? общо no total celkem insgesamt samlet ???????? en total uhtekokku ???? yhteensa au total ???? ??? sveukupan osszesen seluruhnya i heild sinni in tutto ??? ??? is viso kopuma, visuma keseluruhan in totaal samlet. totalt w sumie ?? ????? ???? no total in total в целом. вообще celkom v celoti ukupno totalt [sett] ??????? tum olarak ????,??? повністю ?????? ??? ?? noi chung ????,???

?overalls noun plural

a type of trousers or suit made of hard-wearing materials worn usually over ordinary clothes by workmen etc to protect them from dirt etc . The painter put on his overalls before starting work; I'll need a clean pair of overalls tomorrow. werkpak ??????? ??????? ??? ???????? комбинезон macacao kombineza die Arbeitshose overall; sm?kbukser ????? ???????? mono tunked ???? ??? haalari salopette ???? ???? ??????, ????? kombinezon, radno odijelo szereloruha pakaian kerja (vinnu)samfestingur/-sloppur tuta da lavoro ??????? ??? ??? kombinezonas, specdrabuziai kombinezons baju monyet overall arbeidskl?r. kjeledress. overall kombinezon ? ??? ???? macacao salopeta комбинезон kombineza pajac kombinezon overdragsklader, overall ?????????????????? isci tulumu ????? широкі робочі штани ??? ???? ??? ????? ?? ???? ???????? ???? ????? qu?n ch?t ?ng c?a si quan ???

overall

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Gender-Selective Abortion, Selectine

Gender-selective abortion-choosing abortion solely or primarily because of not preferring the unborn child's sex-is often practiced in several places in the world. Due to cultural biases, female fetuses are generally targeted for abortion in such cases much more often than males.

In the November 9, 2001, cover story of the Indian magazine, Frontline, Nobel Laureate Amartya Sen wrote that "sex-selective abortion" is "particularly prevalent in East Asia, in China and South Korea in particular, but also in Singapore and Taiwan, and it is beginning to emerge as a statistically significant phenomenon in India and South Asia as well." 1

A 1998 study published by the Alan Guttmacher Institute, which was founded as a division of the Planned Parenthood Federation of America, also lists Thailand among the nations in which "sex selection is believed to play a role in abortion." 2

Jyotsna Patro, an Indian delegate to the Asian Church Women's Conference and former president of the Church of North India Women's Fellowship, has recently reported that "[t]he callousness in allowing female feticide is worsening," with "[p]arents hav[ing] no qualms about aborting female fetuses." 3

The widespread practice of sex-selective abortion is believed to be a main cause of the extremely skewed sex ratios at birth in India, where it was recently estimated that only 882 girls are born for every 1,000 boys, and China, where 832 girls are born for every 1,000 boys. 4

While precise estimates vary, there are now tens of millions of "missing women" in the world thanks to sex-selective abortions. In India alone, about 10 million female fetuses are estimated to have been selectively aborted in the last two decades. 5 The Voice of America news service recently reported that "by the year 2020," China is expected to "have 30 million more men than women, making it difficult for many men to find wives." 6 Chinese population expert Chu Junhong has reported that "[p]renatal sex selection was probably the primary cause, if not the sole cause, for the continuous rise of the sex ratio at birth" in China since the implementation of that country's one-child policy. These growing gender imbalances are believed to exacerbate such problems as prostitution and human trafficking. 7 Furthermore, according to Dr. Therese Hesketh, a researcher at the University College London Institute of Child Health and co-author of a recent study on societal gender imbalances, this emergence of large numbers of young men unable to find wives "could lead to increased levels of antisocial behavior and violence." 8

At the March 2007 meeting of the United Nation's Commission on the Status of Women, in New York, a resolution supported by South Korea, the United States, and others would have condemned sex-selective abortion and infanticide and encouraged steps to eliminate them. However, the resolution was ultimately not adopted.9

The United Methodist Social Principles affirm "[o]ur belief in the sanctity of unborn human life" and "unconditionally reject" abortion being used "as a means of gender selection" (¶ 161J). While the members of our denomination are not of one mind over the precise conditions in which abortion can be supported, we cannot support abortion for such trivial reasons as not preferring the gender of the fetus.

The widespread practice of sex-selective abortion horribly treats females as inferior before they are even born. This is absolutely contrary to The United Methodist Church's long history of championing the biblical principle of gender equality.

Therefore, be it resolved, that the General Conference of The United Methodist Church strongly condemns sex-selective abortion as a particularly lamentable and violent expression of sexism. We call on religious, government, and community leaders to proactively pursue humane means for stopping the practice of sex-selective abortion. The General Board of Church and Society is encouraged to seek out and take advantage of opportunities to make this concern of our church known to national leaders of the United States and of other nations.

1. Amartya Sen, "Many Faces of Gender Inequality," Frontline, 9 November 2001; available from ; Internet; accessed 20 August 2007.

2. Akinrinola Bankole, Susheela Singh and Taylor Haas, "Reasons Why Women Have Induced Abortions: Evidence from 27 Countries," International Family Planning Perspectives 24, no. 3 [September 1998]; available from: nals/2411798.html>; accessed 20 August 2007.

3. Anto Akkara, "Indian Christian Women Warn of Female Extinction from Feticide," Ecumenical News International, 26 July 2007; available from tured/article. php? id=1077>; Internet; accessed 20 August 2007.

4. Raekha Prasad and Randeep Ramesh, "India's Missing Girls," Guardian [London], 28 February 2007; available from: 0,,2022983,00.html>; Internet; accessed 20 August 2007. Cf. "China Riots Rooted in Child Policy, Financial Woes," Turkish Daily News, 2 June 2007.

5. Prasad and Ramesh; Cf. Neil Samson Katz and Marisa Sherry, "India: The Missing Girls," Background Facts and Links, PBS FRONTLINE/World "Rough Cut," 26 April 2007; available from: http://www. pbs. org/frontlineworld/rough/2007/04/the_missing_girlinks. html ; Internet; accessed 20 August 2007.

6. Daniel Schearf, "China Acknowledges Family-planning Policy Affects Sex-Ratio Imbalance," Voice of America news, available from: ; Internet; accessed 20 August 2007. Cf. Katharine Mieszkowski, "Millions of Lonely Would-Be Grooms in China," Salon. com, 12 January 2007; available from china/index. html>; Internet; accessed 20 August 2007.

7. Eric Baculinao, "China Grapples with Legacy of its 'Missing Girls': Disturbing Demographic Imbalance Spurs Drive to Change Age-Old Practices," NBC News, 14 Sept 2004; available from ; Internet; accessed 17 August 2007. Cf. Prasad and Ramesh; Isabelle Attane, "The Boys Are Wanted, The Girls Aborted: Asia's Missing Women," trans. Krystyna Horko, Guardian Weekly [London], 11 August 2006, Le Monde Diplomatique section, p. 6.

8. "GENDER RESEARCH: Too Many Men Could Destabilize Society," Biotech Week, 20 September 2006, expanded reporting, p. 564. Cf. Baculinao; Prasad and Ramesh.

9. Andrea Mrozek, "A Recipe for Social Disaster," Calgary Herald [Alberta], 28 March 2007, p. A16.

ADOPTED 2008 RESOLUTION #2027, 2008 BOOK OF RESOLUTIONS

See Social Principles, ¶ 161J.

From The Book of Resolutions of The United Methodist Church - 2012. Copyright © 2012 by The United Methodist Publishing House. Used by permission.

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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Prospect Tagremin, Tagremin

Prospect cu informatii pentru utilizator

Un comprimat contine cotrimoxazolum ( sulfametoxazol 400 mg si trimetoprim 80 mg) si excipienti: laurilsulfat de sodiu, amidon de porumb, stearat de magneziu, povidona K 30, talc, amidonglicolat de sodiu.

Grupa farmacoterapeutica: antibiotice de uz sistemic, combinatii de sulfonamide cu trimethoprim inclusiv derivati.

Tagremin este indicat in infectii produse de germeni sensibili. Pentru tratament curativ este indicat in:

– infectii produse de Pneumocystis carinii;

– toxoplasmoza fara atingere cerebrala la pacienti imunocompetenti;

– infectii uro-genitale la barbati, in special in caz de prostatita;

– infectii urinare joase (cistita acuta) necomplicate la femei sub 65 ani – se poate administra o singura doza;

– infectii ORL (otita sau sinuzita), de preferat pe baza antibiogramei;

– infectii bronhopulmonare;

– infectii digestive, febra tifoida.

Pentru tratament profilactic este indicat:

– pentru profilaxia infectiei cu Pneumocystis carinii la pacientii imunodeprimati (la pacientii infectati cu HIV, administrarea profilactica pe termen lung a sulfametoxazolului si trimetoprimului a redus riscul de pneumocistoza si toxoplasmoza cerebrala);

– la pacientii supusi transplantului de maduva osoasa sau transplantului de organe.

Hipersensibilitate la sulfametoxazol, trimetoprim sau la oricare dintre excipienti.

Reactii alergice in antecedente la alte sulfamide.

Insuficienta hepatica severa.

Insuficienta renala severa la pacienti nedializati.

Deficit de giucozo-6-fosfatdehidrogenaza (risc de hemoliza)

Nou-nascuti sau prematuri.

Tratament concomitent cu metotrexat.

Pacientii alergici la furosemida, diuretice tiazidice, sulfoniluree sau inhibitori ai anhidrazei carbonice pot fi alergici si la sulfamide antibacteriene.

Reactiile adverse cutanate sau hematologice impun intreruperea imediata si definitiva a tratamentului. Au fost raportate cazuri de pancitopenie in cazul asocierii cu metotrexat.

in timpul tratamentului se recomanda un aport hidric suficient (minim 2 I pe zi) pentru a preveni cristaluria.

Sulfamidele antibacteriene pot creste efectul, respectiv riscul toxicitatii pentru metotrexat (risc de pancitopenie); asocierea este contraindicata.

Sulfamidele antibacteriene pot creste efectul, respectiv riscul toxicitatii pentru anticoagulantele cumarinice (datorita riscului de hemoragii se recomanda monitorizarea timpului de protrombina si a INR), sulfamidele antidiabetice (risc de hipoglicemie), fenitoina; aceste fenomene sunt produse prin deplasarea de pe proteinele plasmatice si inhibarea metabolizarii medicamentelor respective. Asocierea trimetoprimului cu medicamente hiperkaliemiante impune prudenta, eventual monitorizarea kaliemiei. Administrarea concomitenta cu zidovudina poate creste riscul toxicitatii hematologice prin inhibarea aditiva a dihidrofolat-reductazei. In cazul in care asocierea este necesara se impune monitorizarea hemogramei. Asocierea cu pirimetamina creste riscul de anemie megaloblastica.

Administrarea concomitenta cu cidosporina poate provoca cresterea creatininemiei si scaderea concentratiei plasmatice si a eficacitatii ciclosporinei.

Asocierea sulfamidelor antibacteriene cu acidul p-aminobenzoic, procaina si acidul folie nu este recomandata, deoarece acestea antagonizeaza actiunea antibacteriana a sulfamidelor.

Asocierea cu mandelamina si, in general, cu substante care acidifica urina favorizeaza precipitarea sulfamidelor in caile urinare. Teste de laborator

Trimetoprimul poate interfera cu dozarea creatininei plasmatice prin metoda acidului picric. Asocierea trimetoprim-sulfametoxazol poate interfera cu dozarea metotrexatului prin metoda legarii de proteine.

La nou-nascuti, mai ales la prematuri, sulfamidele pot produce hiperbilTrubmerhie, cu favorizarea icterului riuCiear. Acest fenomen este posibil si in cazul administrarii la mama inaintea nasterii sau alaptarii sugarilor mai mici de o luna (nou-nascuti).

Reactiile adverse hematologice sunt mai frecvente la varstnici, in cazul carentei preexistente de folati (varstnici, sarcina, alcoolism cronic, insuficienta hepatica cronica, malnutritie, malabsorbtie cronica). in aceste cazuri tulburarile hematologice sunt reversibile dupa administrarea de acid folie.

Se recomanda monitorizare hematologica in caz de tratament prelungit sau repetat, pacienti peste 65 ani, carenta de folati. Tagremin nu se administreaza copiilor sub 12 ani. La aceasta categorie de pacienti se vor utiliza forme farmaceutice si concentratii adecvate varstei.

La pacientii cu insuficienta renala doza se ajusteaza in functie de clearance-ul creatininei.

La pacientii cu insuficienta hepatica se recomanda monitorizarea nivelului transaminazelor si bilirubinei; in caz de antecedente de reactii adverse hematologice se recomanda monitorizarea hemogramei, iar la pacientii cu insuficienta renala, monitorizarea cretininemiei. Supravegherea kaliemiei este necesara la pacientii cu insuficienta renala, pacientii infectati cu HIV, la cei tratati cu doze mari de trimetoprim, la varstnici sau la cei tratati concomitent cu medicamente hiperkaliemiante. Sarcina si alaptarea

Studiile efectuate la animale au evidentiat efecte teratogene la doze mari.

in clinica, utilizarea Tagremin la femeia gravida (intr-un numar limitat de cazuri) nu a determinat nici un efect malformativ, pana in prezent. Totusi, sunt necesare studii suplimentare pentru a putea evalua consecintele utilizarii Tagremin in timpul sarcinii. Pana in prezent, nu s-a raportat nici un caz de icter neonatal dupa utilizarea acestui medicament in timpul sarcinii, in caz de deficit congenital de glucozo-6-fosfatdehidrogenaza, este posibila aparitia unei hemolize neonatale. De aceea, nu se recomanda utilizarea asocierii trimetoprim-sulfametoxazol in timpul sarcinii.

Deoarece sulfamidele antibacteriene se excreta in lapte, alaptarea nou-nascutilor este contraindicata; la sugari se va lua in considerare fie intreruperea tratamentului, fie intreruperea alaptarii. Capacitatea de a conduce vehicule sau de a folosi utilaje

Nu exista date care sa sugereze ca Tagremin influenteaza negativ capacitatea de a conduce vehicule sau de a folosi utilaje; pacientii trebuie avertizati despre riscul foarte mic de aparitie a vertijului.

Doze si mod de administrare

Adulti . doza uzuala de Tagremin este de 2 comprimate la intervale de 12 ore, timp de 10 -14 zile. in caz de infectii severe, se pot administra 6 comprimate Tagremin pe zi in 2 sau 3 prize.

Pentru tratamentul cistitelor acute necomplicate la femei sub 65 ani se pot administra 6 comprimate Tagremin in priza unica. Pentru tratamentul infectiilor produse de Pneumocystis carinii, doza uzuala este de 80-100 mg sulfametoxazol/kg si zi, respectiv 16-20 mg trimetoprim/kg si zi.

Pentru profilaxia infectiilor cu Pneumocystis carinii la pacientii infectati cu HIV doza recomandata este in general, de un comprimat

Pentru tratament profilactic in cazul pacientilor supusi transplantului de maduva osoasa doza recomandata este de 2 comprimate Tagremin de doua ori pe zi, 2 zile consecutive pe saptamana, cel putin 6 luni dupa transplant.

in cazul transplantului de organe se pot administra 2 comprimate Tagremin pe zi sau 2 comprimate de 3 ori pe saptamana.

Nu se recomanda utilizarea medicamentului decat la pacientii dializati.

Se recomanda administrarea dozei reduse la jumatate dupa sedinta de hemodializa. La acesti pacienti se recomanda monitorizarea concentratiei plasmatice a sulfametoxazolului si trimetoprimului.

Reactii alergice: sunt relativ frecvente; alergia este de multe ori incrucisata pentru diferite sulfamide. Manifestarile alergice cele mai obisnuite sunt febra si eruptiile cutanate; mai rare sunt edemul angioneurotic, boala serului, fenomenele de fotosensibilizare si vasculitele alergice asemanatoare eritemului nodos. Foarte rar au fost semnalate cazuri de sindrom Stevens-Johnson si sindrom Lyell.

Tulburari digestive . ocazional apar fenomene de intoleranta digestiva – anorexie, greata, varsaturi, epigastralgii, diaree, colita

pseudomembranoasa. Rareori au fost semnalate cazuri de hepatita colestatica, cresterea transaminazelor si bilirubinemiei.

La pacientii imunocompromisi (infectati cu HIV, supusi transplantului de organe) au fost raportate cazuri de pancreatita.

Tulburari hematologice: au fost se mn a lat e c azuri d o tromboc i top onis, leueopente^ agr a n uloc itoza, aplazie medufarar anemie hemolitica

(provocate probabil printr-un mecanism imunoalergic). La pacientii peste 65 ani, datorita deficitului de folati, riscul reactiilor adverse

hematologice este mai mare in special al anemiei megaloblastice si ai pancitopeniei.

Tulburari renale: au fost semnalate cazuri de insuficienta renala prin nefropatie interstitiala.

Tulburari neurologice: neuropatie periferica, parestezii, rareori au fost raportate cazuri de meningita aseptica, ataxie, convulsii, vertij, tremorsi convulsii.

Exceptional au fost semnalate cazuri de uveita.

Tulburariosteo-musculare: au fost raportate rare cazuri de artralgii, mialgii, rabdomioliza.

Tulburari metabolice: hiperkaliemie reversibila la intreruperea tratamentului, rareori hiponatriemie si acidoza metabolica; htpogHcemia a fost semnalata uneori la pacienti nediabetici.

La nou-nascuti sulfamidele antibacteriene pot favoriza icterul nuclear.

Reactii adverse mai frecvente la pacientii cu SIDA/infectati cu HIV: tulburari cutanate, hipertermie, leucopenie, cresterea transaminazelor si hiperkaliemie au fost semnalate in special dupa administrarea unor doze mari. Producerea pancreatitei si rabdomiolizei este mai frecventa in cazul asocierii cu alte medicamente care favorizeaza aceste reactii adverse.

Supradozajul dupa doze repetate poate provoca deprimarea functiei hematopoetice medulare, manifestata prin trombocitopenie, leucopenie sau printr-o alta tulburare hematologica datorata carentei de acid folie.

in caz de supradozaj recent se recomanda efectuarea lavajului gastric, provocarea varsaturilor, fortarea diurezei, la nevoie hemodializa (dializa peritoneala nu este eficace). Este necesara supraveghere hematologica si electrolitica. in cazul aparitiei tulburarilor hematologice sau icterului se instituie tratamentul specific. Uneori poate fi necesara administrarea injectabila intramuscular a acidului folie. Pastrare

A nu se utiliza dupa data de expirare inscrisa pe ambalaj. A se pastra la temperaturi sub 25°C, in ambalajul original. A nu se lasa la indemana copiilor. Ambalaj

Cutie cu 2 blistere din PVC/Al a cate 10 comprimate.

B-dui Theodor Pallady nr. 50, Sector 3,032266 Bucuresti, Romania Detinatorul Autorizatiei de punere pe piata

B-dul Theodor Pallady nr. 50, Sector 3,032266 Bucuresti, Romania Data ultimei verificari a prospectului

Scheriproct Ointment, Prednisolon Caproate

PROPRIETARY NAME (and dosage form):

COMPOSITION 1 g ointment contains prednisolone caproate (1,4-pregnadiene-3,20-dione-11beta-17alpha,21-triol-21-caproate) 1,9 mg and cinchocaine hydrochloride as the hydrochloride of (2-butoxy-N-(2-diethylaminoethyl)cinchonamide) 5 mg.

PHARMACOLOGICAL CLASSIFICATION A. 11.8 Anal suppositories and ointments.

PHARMACOLOGICAL ACTION Prednisolone exerts an antiinflammatory and antipruritic effect. Capillary dilatation, intercellular oedema and tissue infiltration regress; capillary proliferation is suppressed. As a local anaesthetic, cinchocaine eases the pain.

INDICATIONS Short term symptomatic relief of perianal discomfort, inflammation and itching caused by thrombosed haemorrhoids, anal fissure and pruritus ani.

CONTRA-INDICATIONS Hypersensitivity to any of the ingredients. Viral infections, primary bacterial or fungal infections in the treatment area. Secondary infections of the skin in the absence of appropriate antiinfective therapy. Known sensitivity to local anaesthetics. Corticosteroids have been shown to be teratogenic in animals following dermal application. As these agents are absorbed percutaneously, teratogenicity following topical applicati on cannot be excluded. Therefore, Scheriproct should not be used during pregnancy. The excretion of effective amounts of glucocorticoid with the breast milk is improbable.

WARNINGS This product should not be used continuously for more than 7 days. If symptoms do not disappear quickly, discontinue treatment and consult your doctor. Certain anal disorders require specific treatment and a proctological examination. In case of bleeding, consult a doctor promptly.

DOSAGE AND DIRECTIONS FOR USE The anal region should be cleaned thoroughly before using Scheriproct, which is best applied after defaecation. Unless otherwise prescribed by the doctor, generally apply twice daily. On the first day, for faster symptomatic relief, up to four times. Smear a little ointment (about the size of a pea) around the anus and in the anal ring with a finger and use the finger-tip to overcome the resistance of the sphincter. Before applying within the rectum, the enclosed nozzle should be screwed on to the tube. However, for very inflamed and hence painful lesions it is advisable initially to apply the ointment internally with the finger. Protruding lumps should be thickly smeared and carefully pressed back with the finger.

SIDE EFFECTS AND SPECIAL PRECAUTIONS In infants, long-term continuous therapy with topical corticosteroids should be avoided. Occlusion is not appropriate on the perineum. Adrenal suppression can occur, even without occlusion. There is a risk of developing skin atrophy following extensive therapy. The application of unusually large quantities of topical corticoids may result in the absorption of systemically active amounts of corticoid. Infections or secondarily infected dermatoses definitely require additional therapy with antibiotics or chemotherapeutic agents. This treatment can often be topical, but for heavy infections systemic antibacterial therapy may be necessary. If fungal infections are present, a topically active antimycotic should be applied. Allergic skin reactions may occur. Inadvertent contact of the preparation with the eyes should be avoided. Careful handwashing after use is recommended.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT In the case of accidental oral intake of the preparation (eg by swallowing a few grams of the ointment) mainly systemic effects of the local anaesthetic cinchocaine hydrochloride are to be expected, which, according to the dose, may manifest themselves as severe cardiovascular (depression to cessation of cardiac function) and CNS symptoms (convulsions; inhibition to arrest of respiratory function).

IDENTIFICATION Colourless to slightly yellowish translucent ointment.

PRESENTATION White coloured aluminium tubes, interior wall coated with epoxy resin, containing 15 or 30 g.

STORAGE INSTRUCTIONS Store below 25°C. For shelf-life, please refer to the imprint on the pack. Keep out of reach of children.

REGISTRATION NUMBER E/11.8/0667

NAME AND BUSINESS ADDRESS OF THE APPLICANT Schering (Pty) Ltd (Reg No: 1964/009072/07) 106 Sixteenth Road Randjespark Midrand 1685 P O Box 5278 Halfway House 1685

DATE OF PUBLICATION OF THIS PACKAGE INSERT 3 August 2000

SCHERING (PTY) LTD (Reg No: 1964/009072/07) Subsidiary of Schering AG Germany

Updated on this site: April 2003 Current: January 2005 Source: Pharmaceutical Industry SAEPI HOME PAGE TRADE NAME INDEX GENERIC NAME INDEX FEEDBACK Information presented by Malahyde Information Systems © Copyright 1996-2005

Urban Dictionary Haram, Hartam

When a honey comes up and you can see her forehead or eyes and you know you be think all kinds a dirty thoughts.

When you be partyin' and someone offers you anything to drink other than water.

When you be all 'umcha umcha' and listenin' to yo beats.

Anything that is fun/something you get joy out of.

Man1:"Yo did you see that chicks eyes yesterday" Man2: "Yea man why didn't you look away that chick haram as hell, why you think they call her a hoejabi Haabeel"

Valley girl muslim wearing designer hijab:1:"So like I totally love this new electro-house band, they're really awesome" Valley girl muslim wearing designer hijab2:"Wow you know that music is forbidden right, we totally shouldn't be listening to that"

by Le Taqwa August 07, 2011

1) In Islam, a forbidden activity, food, drink, or thought. Examples of haram things are: eating pork, drinking alcohol, having sex at daytime during Ramadan. extramarital sex, neglect of prayer and fasting, and blasphemy.

2) In the slang of Arabic and languages influenced by Arabic, anything evil or sinful. Forms compounds like Arabic ibn haram 'bastard' (lit. 'son of sin'), and Malay anak haram (also meaning 'bastard').

Uh, isn't making out in a mosque kind of a haram activity? I don't think it matters if you're married.

by LudwigVan August 23, 2004

Free Daily Email

Emails are sent from daily@urbandictionary. com. We'll never spam you.

Olmax H; Tablet, Glenmark Pharmaceuticals Limited, Olmax-H

Olmax H - Tablet, Glenmark Pharmaceuticals Limited

If you are Pharmaceutical manufacturer. contract manufacturer, machine manufacturer. bulk drug manufacturer or provide facility like pharmaceutical product printing. packaging and consulting then dawabazar. in is a perfect place to promote your business with your brand/products/services.

Create profile and manage brand/products/services for free and get listed in various search

If you are Pharmaceutical dealer, supplier, stokist. wholeseller or distributor and deales in allopathy medicines, ayurvedic medicines, homeopathic medicines. scientific instruments, pharmaceutical machinery. surgical appliances and instruments. medical devices and health devices then this website is for you to enhance your business.

Create profile and manage products for free and get listed in various search

If you are pharmaceutical retailer or chemist then this place for you to increase your sales and get medicine enquiry from common person. You can find pharmaceutical dealers and stockiest list according to your city for any pharmaceutical company and its product.

Create profile for free and get listed in various search

Dawabazar. in is a free content encyclopedia especially for pharmaceutical field. This website provides information about all manufacturing. marketing companies and their products, its compositions along with its dealers. retailers in India. This website also provides many findings on medicines, Pharma companies, Pharma dealers, Pharma retailers, active pharmaceutical ingredients, therapeutic index and pharmacological index which is useful for doctors. medical students and common person.

Diaformin (Metformin Hydrochloride) Drug, Diaformin

Diaformin

NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia. This page contains answers to some common questions about Diaformin. It does not contain all the information that is known about Diaformin. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risk of you using this medicine against the benefits he/she expects it will have for you. If you have any concerns about using this medicine, ask your doctor or pharmacist. Bookmark or print this page, you may need to read it again.

What Diaformin is used for

Diaformin is used to control blood glucose (the amount of sugar in the blood) in people with diabetes mellitus.

Diaformin can be used in type 2 diabetes in adults and children over 10 years of age. It is especially useful in those who are overweight, when diet and exercise are not enough to lower high blood glucose levels (hyperglycaemia). For adult patients, metformin can be used alone, or in combination with other oral diabetic medicines or in combination with insulin in insulin requiring type 2 diabetes.

Ask your doctor if you have any questions about why Diaformin has been prescribed for you.

Your doctor may have prescribed Diaformin for another reason.

Diaformin is available only with a doctor's prescription.

There is no evidence that Diaformin is addictive.

How Diaformin works

Diaformin belongs to a group of medicines called biguanides. Diaformin lowers high blood glucose (hyperglycaemia) by helping your body make better use of the insulin produced by your pancreas.

People with type 2 diabetes are unable to make enough insulin or their body does not respond properly to the insulin it does make. This causes a build up of glucose in the blood, which can lead to serious medical problems.

Long-term hyperglycaemia can lead to heart disease, blindness, kidney damage, poor blood circulation and gangrene.

Signs of hyperglycaemia may include:

tiredness or lack of energy

Enjoy healthy eating by:

eating plenty of vegetables and fruit;

reducing your saturated fat intake (eat less fatty meats, full fat dairy products, butter, coconut and palm oils, most take-away foods, commercially-baked products).

Be active. Progress, over time, to at least 30 minutes of moderate-intensity physical activity on 5 or more days each week. Can be accumulated in shorter bouts of 10 minutes duration. If you have been prescribed anti-angina medicine, carry it with you when being physically active

Maintain a healthy weight

Discuss your lifestyle and lifestyle plans with your doctor

For more information and tools to improve your heart health, call Heartline, the Heart Foundation's national telephone information service, on 1300 36 27 87 (local call cost)

Know warning signs of heart attack and what to do:

Tightness, fullness, pressure, squeezing, heaviness or pain in your chest, neck, jaw, throat, shoulders, arms or back

You may also have difficulty breathing, or have a cold sweat or feel dizzy or light headed or feel like vomiting (or actually vomit)

If you have heart attack warning signs that are severe, get worse or last for 10 minutes even if they are mild, call triple zero (000). Every minute counts.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Diaformin.

Diaformin helps most people with diabetes but it may have unwanted side effects in some people.

All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.

If you are over 65 years of age, you may have an increased chance of getting side effects.

Do not be alarmed by the following lists of side effects.

You may not experience any of them.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor or pharmacist if you notice any of the following and they worry you:

feeling sick (nausea)

Nifedical Xl - Fda Prescribing Information, Side Effects And Uses, Nifedical

Nifedical XL

Nifedical XL Description

Nifedipine is a drug belonging to a class of pharmacological agents known as the calcium channel blockers. Nifedipine is 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester, C 17 H 18 N 2 O 6. and has the structural formula:

Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. It has a molecular weight of 346.3. Each extended-release tablet, formulated as a once-a-day controlled release tablet for oral administration, delivers 30 or 60 mg of nifedipine.

In addition, each extended-release tablet contains the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, ethylcellulose, hydroxyethyl cellulose, hypromellose, magnesium stearate, methacrylic acid copolymer type A, methacrylic acid copolymer type B, microcrystalline cellulose, polyethylene glycol, red ferric oxide, sodium lauryl sulfate, talc and titanium dioxide.

Nifedipine Extended-release Tablets meet USP Dissolution Test 3.

Nifedical XL - Clinical Pharmacology

Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Nifedipine selectively inhibits calcium ion influx across the cell membrane of cardiac muscle and vascular smooth muscle without altering serum calcium concentrations.

Mechanism of Action

The precise mechanisms by which inhibition of calcium influx relieves angina has not been fully determined, but includes at least the following two mechanisms:

1) Relaxation and Prevention of Coronary Artery Spasm

Nifedipine dilates the main coronary arteries and coronary arterioles, both in normal and ischemic regions, and is a potent inhibitor of coronary artery spasm, whether spontaneous or ergonovine-induced. This property increases myocardial oxygen delivery in patients with coronary artery spasm, and is responsible for the effectiveness of nifedipine in vasospastic (Prinzmetal's or variant) angina. Whether this effect plays any role in classical angina is not clear, but studies of exercise tolerance have not shown an increase in the maximum exercise rate-pressure product, a widely accepted measure of oxygen utilization. This suggests that, in general, relief of spasm or dilation of coronary arteries is not an important factor in classical angina.

2) Reduction of Oxygen Utilization

Nifedipine regularly reduces arterial pressure at rest and at a given level of exercise by dilating peripheral arterioles and reducing the total peripheral vascular resistance (afterload) against which the heart works. This unloading of the heart reduces myocardial energy consumption and oxygen requirements, and probably accounts for the effectiveness of nifedipine in chronic stable angina.

The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and the resulting reduction in peripheral vascular resistance. The increased peripheral vascular resistance that is an underlying cause of hypertension results from an increase in active tension in the vascular smooth muscle. Studies have demonstrated that the increase in active tension reflects an increase in cytosolic free calcium.

Nifedipine is a peripheral arterial vasodilator which acts directly on vascular smooth muscle. The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. Stores of intracellular calcium in vascular smooth muscle are limited and thus dependent upon the influx of extracellular calcium for contraction to occur. The reduction in calcium influx by nifedipine causes arterial vasodilation and decreased peripheral vascular resistance which results in reduced arterial blood pressure.

Pharmacokinetics and Metabolism

Nifedipine is completely absorbed after oral administration. Plasma drug concentrations rise at a gradual, controlled rate after a nifedipine extended-release tablet dose and reach a plateau at approximately six hours after the first dose. For subsequent doses, relatively constant plasma concentrations at this plateau are maintained with minimal fluctuations over the 24-hour dosing interval. About a four-fold higher fluctuation index (ratio of peak to trough plasma concentration) was observed with the conventional immediate-release nifedipine capsule at t. i.d. dosing than with once daily nifedipine extended-release tablet. At steady-state the bioavailability of the nifedipine extended-release tablet is 86% relative to nifedipine capsules. Administration of the nifedipine extended-release tablet in the presence of food slightly alters the early rate of drug absorption, but does not influence the extent of drug bioavailability. Markedly reduced GI retention time over prolonged periods (i. e. short bowel syndrome), however, may influence the pharmacokinetic profile of the drug which could potentially result in lower plasma concentrations. Pharmacokinetics of nifedipine extended-release tablets are linear over the dose range of 30 to 180 mg in that plasma drug concentrations are proportional to dose administered. There was no evidence of dose dumping either in the presence or absence of food for over 150 subjects in pharmacokinetic studies.

Nifedipine is extensively metabolized to highly water-soluble, inactive metabolites accounting for 60 to 80% of the dose excreted in the urine. The elimination half-life of nifedipine is approximately two hours. Only traces (less than 0.1% of the dose) of unchanged form can be detected in the urine. The remainder is excreted in the feces in metabolized form, most likely as a result of biliary excretion. Thus, the pharmacokinetics of nifedipine are not significantly influenced by the degree of renal impairment. Patients in hemodialysis or chronic ambulatory peritoneal dialysis have not reported significantly altered pharmacokinetics of nifedipine. Since hepatic biotransformation is the predominant route for the disposition of nifedipine, the pharmacokinetics may be altered in patients with chronic liver disease. Patients with hepatic impairment (liver cirrhosis) have a longer disposition half-life and higher bioavailability of nifedipine than healthy volunteers. The degree of serum protein binding of nifedipine is high (90 to 98%). Protein binding may be greatly reduced in patients with renal or hepatic impairment.

Like other slow-channel blockers, nifedipine exerts a negative inotropic effect on isolated myocardial tissue. This is rarely, if ever, seen in intact animals or man, probably because of reflex responses to its vasodilating effects. In man, nifedipine decreases peripheral vascular resistance which leads to a fall in systolic and diastolic pressures, usually minimal in normotensive volunteers (less than 5 to 10 mm Hg systolic), but sometimes larger. With nifedipine extended-release tablets, these decreases in blood pressure are not accompanied by any significant change in heart rate. Hemodynamic studies in patients with normal ventricular function have generally found a small increase in cardiac index without major effects on ejection fraction, left ventricular end diastolic pressure (LVEDP) or volume (LVEDV). In patients with impaired ventricular function, most acute studies have shown some increase in ejection fraction and reduction in left ventricular filling pressure.

Although, like other members of its class, nifedipine causes a slight depression of sinoatrial node function and atrioventricular conduction in isolated myocardial preparations, such effects have not been seen in studies in intact animals or in man. In formal electrophysiologic studies, predominantly in patients with normal conduction systems, nifedipine has had no tendency to prolong atrioventricular conduction or sinus node recovery time, or to slow sinus rate.

Indications and Usage for Nifedical XL

I. Vasospastic Angina

Nifedical XL ® tablets are indicated for the management of vasospastic angina confirmed by any of the following criteria: 1) classical pattern of angina at rest accompanied by ST segment elevation, 2) angina or coronary artery spasm provoked by ergonovine, or 3) angiographically demonstrated coronary artery spasm. In those patients who have had angiography, the presence of significant fixed obstructive disease is not incompatible with the diagnosis of vasospastic angina, provided that the above criteria are satisfied. Nifedical XL ® tablets may also be used where the clinical presentation suggests a possible vasospastic component but where vasospasm has not been confirmed, e. g. where pain has a variable threshold on exertion or in unstable angina where electrocardiographic findings are compatible with intermittent vasospasm, or when angina is refractory to nitrates and/or adequate doses of beta-blockers.

II. Chronic Stable Angina (Classical Effort-Associated Angina)

Nifedical XL ® tablets are indicated for the management of chronic stable angina (effort-associated angina) without evidence of vasospasm in patients who remain symptomatic despite adequate doses of beta-blockers and/or organic nitrates or who cannot tolerate those agents.

In chronic stable angina (effort-associated angina) nifedipine has been effective in controlled trials of up to eight weeks duration in reducing angina frequency and increasing exercise tolerance, but confirmation of sustained effectiveness and evaluation of long-term safety in these patients is incomplete.

Controlled studies in small numbers of patients suggest concomitant use of nifedipine and beta-blocking agents may be beneficial in patients with chronic stable angina, but available information is not sufficient to predict with confidence the effects of concurrent treatment, especially in patients with compromised left ventricular function or cardiac conduction abnormalities. When introducing such concomitant therapy, care must be taken to monitor blood pressure closely since severe hypotension can occur from the combined effects of the drugs (see WARNINGS ).

III. Hypertension

Nifedical XL ® tablets are indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.

Contraindications

Known hypersensitivity reaction to nifedipine.

Warnings

Excessive Hypotension

Although in most angina patients the hypotensive effect of nifedipine is modest and well tolerated, occasional patients have had excessive and poorly tolerated hypotension. These responses have usually occurred during initial titration or at the time of subsequent upward dosage adjustment, and may be more likely in patients on concomitant beta-blockers.

Severe hypotension and/or increased fluid volume requirements have been reported in patients receiving nifedipine together with a beta-blocking agent who underwent coronary artery bypass surgery using high-dose fentanyl anesthesia. The interaction with high-dose fentanyl appears to be due to the combination of nifedipine and a beta-blocker, but the possibility that it may occur with nifedipine alone, with low doses of fentanyl, in other surgical procedures, or with other narcotic analgesics cannot be ruled out. In nifedipine-treated patients where surgery using high-dose fentanyl anesthesia is contemplated, the physician should be aware of these potential problems and if the patient's condition permits, sufficient time (at least 36 hours) should be allowed for nifedipine to be washed out of the body prior to surgery.

The following information should be taken into account in those patients who are being treated for hypertension as well as angina:

Increased Angina and/or Myocardial Infarction

Rarely, patients, particularly those who have severe obstructive coronary artery disease, have developed well documented increased frequency, duration and/or severity of angina or acute myocardial infarction on starting nifedipine or at the time of dosage increase. The mechanism of this effect is not established.

Beta-Blocker Withdrawal

It is important to taper beta-blockers if possible, rather than stopping them abruptly before beginning nifedipine. Patients recently withdrawn from beta-blockers may develop a withdrawal syndrome with increased angina, probably related to increased sensitivity to catecholamines. Initiation of nifedipine treatment will not prevent this occurrence and on occasion has been reported to increase it.

Congestive Heart Failure

Rarely, patients, usually receiving a beta blocker, have developed heart failure after beginning nifedipine. Patients with tight aortic stenosis may be at greater risk for such an event, as the unloading effect of nifedipine would be expected to be of less benefit, owing to the fixed impedance to flow across the aortic valve in these patients.

Gastrointestinal Obstruction Requiring Surgery

There have been rare reports of obstructive symptoms in patients with known strictures in association with the ingestion of nifedipine. Bezoars can occur in very rare cases and may require surgical intervention.

Cases of serious gastrointestinal obstruction have been identified in patients with no known gastrointestinal disease, including the need for hospitalization and surgical intervention.

Risk factors for gastrointestinal obstruction identified from post-marketing reports of nifedipine extended-release tablets include alteration in gastrointestinal anatomy (severe gastrointestinal narrowing, colon cancer, small bowel obstruction, bowel resection, gastric bypass, vertical banded gastroplasty, and colostomy), hypomotility disorders (constipation, gastroesophageal reflux disease, ileus, obesity, hypothyroidism, and diabetes) and concomitant medications (H2-histamine blockers, nonsteroidal anti-inflammatory drugs, laxatives, anticholinergic agents, and levothyroxine).

Precautions

General - Hypotension: Because nifedipine decreases peripheral vascular resistance, careful monitoring of blood pressure during the initial administration and titration of nifedipine is suggested. Close observation is especially recommended for patients already taking medications that are known to lower blood pressure (see WARNINGS ).

Peripheral Edema: Mild to moderate peripheral edema occurs in a dose dependent manner with an incidence ranging from approximately 10% to about 30% at the highest dose studied (180 mg). It is a localized phenomenon thought to be associated with vasodilation of dependent arterioles and small blood vessels and not due to left ventricular dysfunction or generalized fluid retention. With patients whose angina or hypertension is complicated by congestive heart failure, care should be taken to differentiate this peripheral edema from the effects of increasing left ventricular dysfunction.

Information for Patients: Nifedical XL ® tablets should be swallowed whole. Do not chew, divide or crush tablets.

Laboratory Tests: Rare, usually transient, but occasionally significant elevations of enzymes such as alkaline phosphatase, CPK, LDH, SGOT, and SGPT have been noted. The relationship to nifedipine therapy is uncertain in most cases, but probable in some. These laboratory abnormalities have rarely been associated with clinical symptoms; however, cholestasis with or without jaundice has been reported. A small (5.4%) increase in mean alkaline phosphatase was noted in patients treated with nifedipine extended release tablets. This was an isolated finding not associated with clinical symptoms and it rarely resulted in values which fell outside the normal range. Rare instances of allergic hepatitis have been reported. In controlled studies, nifedipine extended-release tablets did not adversely affect serum uric acid, glucose, or cholesterol. Serum potassium was unchanged in patients receiving nifedipine extended-release tablets in the absence of concomitant diuretic therapy, and slightly decreased in patients receiving concomitant diuretics.

Nifedipine, like other calcium channel blockers, decreases platelet aggregation in vitro. Limited clinical studies have demonstrated a moderate but statistically significant decrease in platelet aggregation and an increase in bleeding time in some nifedipine patients. This is thought to be a function of inhibition of calcium transport across the platelet membrane. No clinical significance for these findings has been demonstrated.

Positive direct Coombs test, with/without hemolytic anemia, has been reported, but a causal relationship between nifedipine administration and positivity of this laboratory test, including hemolysis, could not be determined.

Although nifedipine has been used safely in patients with renal dysfunction and has been reported to exert a beneficial effect in certain cases, rare, reversible elevations in BUN and serum creatinine have been reported in patients with preexisting chronic renal insufficiency. The relationship to nifedipine therapy is uncertain in most cases but probable in some.

Drug Interactions: Beta-adrenergic blocking agents: (see INDICATIONS AND USAGE and WARNINGS ). Experience in over 1400 patients with nifedipine capsules in a noncomparative clinical trial has shown that concomitant administration of nifedipine and beta-blocking agents is usually well tolerated, but there have been occasional literature reports suggesting that the combination may increase the likelihood of congestive heart failure, severe hypotension, or exacerbation of angina.

Long-acting Nitrates: Nifedipine may be safely coadministered with nitrates, but there have been no controlled studies to evaluate the antianginal effectiveness of this combination.

Digitalis: Administration of nifedipine with digoxin increased digoxin levels in nine of twelve normal volunteers. The average increase was 45%. Another investigator found no increase in digoxin levels in thirteen patients with coronary artery disease. In an uncontrolled study of over two hundred patients with congestive heart failure during which digoxin blood levels were not measured, digitalis toxicity was not observed. Since there have been isolated reports of patients with elevated digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over - or under-digitalization.

Coumarin Anticoagulants: There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom nifedipine was administered. However, the relationship to nifedipine therapy is uncertain.

Cimetidine: A study in six healthy volunteers has shown a significant increase in peak nifedipine plasma levels (80%) and area-under-the-curve (74%), after a one-week course of cimetidine at 1000 mg per day and nifedipine at 40 mg per day. Ranitidine produced smaller, non-significant increases. The effect may be mediated by the known inhibition of cimetidine on hepatic cytochrome P-450, the enzyme system probably responsible for the first-pass metabolism of nifedipine. If nifedipine therapy is initiated in a patient currently receiving cimetidine, cautious titration is advised.

Carcinogenesis, Mutagenesis, Impairment of Fertility: Nifedipine was administered orally to rats for two years and was not shown to be carcinogenic. When given to rats prior to mating, nifedipine caused reduced fertility at a dose approximately 30 times the maximum recommended human dose. There is a literature report of reversible reduction in the ability of human sperm obtained from a limited number of infertile men taking recommended doses of nifedipine to bind to and fertilize an ovum in vitro. In vivo mutagenicity studies were negative.

Pregnancy: Pregnancy Category C: Nifedipine has been shown to produce teratogenic findings in rats and rabbits, including digital anomalies similar to those reported to phenytoin. Digital anomalies have been reported to occur with other members of the dihydropyridine class and are possibly a result of compromised uterine blood flow. Nifedipine administration was associated with a variety of embryotoxic, placentotoxic, and fetotoxic effects, including stunted fetuses (rats, mice, rabbits), rib deformities (mice), cleft palate (mice), small placentas and underdeveloped chorionic villi (monkeys), embryonic and fetal deaths (rats, mice, rabbits), and prolonged pregnancy/decreased neonatal survival (rats: not evaluated in other species). On a mg/kg basis, all of the doses associated with the teratogenic embryotoxic or fetotoxic effects in animals were higher (3.5 to 42 times) than the maximum recommended human dose of 120 mg/day. On a mg/m 2 basis, some doses were higher and some were lower than the maximum recommended human dose but all are within an order of magnitude of it. The doses associated with placentotoxic effects in monkeys were equivalent to or lower than the maximum recommended human dose on a mg/m 2 basis.

There are no adequate and well-controlled studies in pregnant women. Nifedical XL ® Extended-release tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Pediatric Use: Safety and effectiveness in pediatric patients have not been established.

Adverse Reactions

Over 1000 patients from both controlled and open trials with nifedipine extended-release tablets in hypertension and angina were included in the evaluation of adverse experiences. All side effects reported during nifedipine extended-release tablet therapy were tabulated independent of the causal relation to medication. The most common side effect reported with nifedipine extended-release tablet was edema which was dose related and ranged in frequency from approximately 10% to about 30% at the highest dose studied (180 mg). Other common adverse experiences reported in placebo-controlled trials include:

NIFEDIPINE EXTENDED-RELEASE TABLETS (%) (n=707)

Of these, only edema and headache were more common in patients given nifedipine extended-release tablets than placebo patients.

The following adverse reactions occurred with an incidence of less than 3.0%. With the exception of leg cramps, the incidence of these side effects was similar to that of placebo alone.

Body as a Whole/Systemic: asthenia, flushing, pain Cardiovascular: palpitations Central Nervous System: insomnia, nervousness, paresthesia, somnolence Dermatologic: pruritus, rash Gastrointestinal: abdominal pain, diarrhea, dry mouth, dyspepsia, flatulence Musculoskeletal: arthralgia, leg cramps Respiratory: chest pain (nonspecific), dyspnea Urogenital: impotence, polyuria

Other adverse reactions were reported sporadically with an incidence of 1.0% or less. These include:

Body as a Whole/Systemic: face edema, fever, hot flashes, malaise, periorbital edema, rigors Cardiovascular: arrhythmia, hypotension, increased angina, tachycardia, syncope Central Nervous System: anxiety, ataxia, decreased libido, depression, hypertonia, hypoesthesia, migraine, paroniria, tremor, vertigo Dermatologic: alopecia, increased sweating, urticaria, purpura Gastrointestinal: eructation, gastroesophageal reflux, gum hyperplasia, melena, vomiting, weight increase Musculoskeletal: back pain, gout, myalgias Respiratory: coughing, epistaxis, upper respiratory tract infection, respiratory disorder, sinusitis Special Senses: abnormal lacrimation, abnormal vision, taste perversion, tinnitus Urogenital/Reproductive: breast pain, dysuria, hematuria, nocturia

Adverse experiences which occurred in less than 1 in 1000 patients cannot be distinguished from concurrent disease states or medications.

The following adverse experiences, reported in less than 1% of patients, occurred under conditions (e. g. open trials, marketing experiences) where a causal relationship is uncertain: gastrointestinal irritation, gastrointestinal bleeding, gynecomastia.

Gastrointestinal obstruction resulting in hospitalization and surgery, including the need for bezoar removal, has occurred in association with nifedipine extended-release tablets, even in patients with no prior history of gastrointestinal disease.

In multiple-dose U. S. and foreign controlled studies with nifedipine capsules in which adverse reactions were reported spontaneously, adverse effects were frequent but generally not serious and rarely required discontinuation of therapy or dosage adjustment. Most were expected consequences of the vasodilator effects of nifedipine.

NIFEDIPINE Capsule (%) (n=226)

There is also a large uncontrolled experience in over 2100 patients in the United States. Most of the patients had vasospastic or resistant angina pectoris, and about half had concomitant treatment with beta-adrenergic blocking agents. The relatively common adverse events were similar in nature to those seen with nifedipine extended-release tablets.

In addition, more serious adverse events were observed, not readily distinguishable from the natural history of the disease in these patients. It remains possible, however, that some or many of these events were drug related. Myocardial infarction occurred in about 4% of patients and congestive heart failure or pulmonary edema in about 2%. Ventricular arrhythmias or conduction disturbances each occurred in fewer than 0.5% of patients.

In a subgroup of over 1000 patients receiving nifedipine with concomitant beta-blocker therapy, the pattern and incidence of adverse experiences was not different from that of the entire group of nifedipine treated patients (see PRECAUTIONS ).

In a subgroup of approximately 250 patients with a diagnosis of congestive heart failure as well as angina, dizziness or lightheadedness, peripheral edema, headache or flushing each occurred in one in eight patients. Hypotension occurred in about one in 20 patients. Syncope occurred in approximately one patient in 250. Myocardial infarction or symptoms of congestive heart failure each occurred in about one patient in 15. Atrial or ventricular dysrhythmias each occurred in about one patient in 150.

In post-marketing experience, there have been rare reports of exfoliative dermatitis caused by nifedipine. There have been rare reports of exfoliative or bullous skin adverse events (such as erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis) and photosensitivity reactions.

Overdosage

Experience with nifedipine overdosage is limited. Generally, overdosage with nifedipine leading to pronounced hypotension calls for active cardiovascular support including monitoring of cardiovascular and respiratory function, elevation of extremities, judicious use of calcium infusion, pressor agents and fluids. Clearance of nifedipine would be expected to be prolonged in patients with impaired liver function. Since nifedipine is highly protein-bound, dialysis is not likely to be of any benefit.

There has been one reported case of massive overdosage with nifedipine extended-release tablets. The main effects of ingestion of approximately 4800 mg of nifedipine extended-release tablets in a young man attempting suicide as a result of cocaine-induced depression was initial dizziness, palpitations, flushing, and nervousness. Within several hours of ingestion, nausea, vomiting, and generalized edema developed. No significant hypotension was apparent at presentation, 18 hours post-ingestion. Electrolyte abnormalities consisted of a mild, transient elevation of serum creatinine, and modest elevations of LDH and CPK, but normal SGOT. Vital signs remained stable, no electrocardiographic abnormalities were noted and renal function returned to normal within 24 to 48 hours with routine supportive measures alone. No prolonged sequelae were observed.

The effect of a single 900 mg ingestion of nifedipine capsules in a depressed anginal patient also on tricyclic antidepressants was loss of consciousness within 30 minutes of ingestion, and profound hypotension, which responded to calcium infusion, pressor agents, and fluid replacement. A variety of ECG abnormalities were seen in this patient with a history of bundle branch block, including sinus bradycardia and varying degrees of AV block. These dictated the prophylactic placement of a temporary ventricular pacemaker, but otherwise resolved spontaneously. Significant hyperglycemia was seen initially in this patient, but plasma glucose levels rapidly normalized without further treatment.

A young hypertensive patient with advanced renal failure ingested 280 mg of nifedipine capsules at one time, with resulting marked hypotension responding to calcium infusion and fluids. No AV conduction abnormalities, arrhythmias, or pronounced changes in heart rate were noted, nor was there any further deterioration in renal function.

Nifedical XL Dosage and Administration

Dosage must be adjusted according to each patient's needs. Therapy for either hypertension or angina should be initiated with 30 or 60 mg once daily. Nifedical XL ® Extended-release tablets should be swallowed whole and should not be bitten or divided. In general, titration should proceed over a 7 to 14 day period so that the physician can fully assess the response to each dose level and monitor blood pressure before proceeding to higher doses. Since steady-state plasma levels are achieved on the second day of dosing, if symptoms so warrant, titration may proceed more rapidly provided the patient is assessed frequently. Titration to doses above 120 mg are not recommended.

Angina patients controlled on nifedipine capsules alone or in combination with other antianginal medications may be safely switched to Nifedical XL ® Extended-release tablets at the nearest equivalent total daily dose. Subsequent titration to higher or lower doses may be necessary and should be initiated as clinically warranted. Experience with doses greater than 90 mg in patients with angina is limited. Therefore, doses greater than 90 mg should be used with caution and only when clinically warranted.

No "rebound effect" has been observed upon discontinuation of nifedipine extended-release tablets. However, if discontinuation of nifedipine is necessary, sound clinical practice suggests that the dosage should be decreased gradually with close physician supervision.

Care should be taken when dispensing Nifedical XL ® Extended-release Tablets to assure that the extended-release dosage form has been prescribed.

Coadministration with Other Antianginal Drugs

Sublingual nitroglycerin may be taken as required for the control of acute manifestations of angina, particularly during nifedipine titration. See PRECAUTIONS, Drug Interactions. for information on coadministration of nifedipine with beta-blockers or long-acting nitrates.

How is Nifedical XL Supplied

Nifedical XL ® Extended-release Tablets, USP, are supplied as 30 and 60 mg reddish brown, unscored, film-coated, round tablets, debossed with "B" on one side and "30" or "60" on the other.

Nifedical XL ® Extended-release Tablets, USP, are supplied in:

Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [See USP Controlled Room Temperature].

Protect from moisture and humidity.

Dispense in a tight, light-resistant container.

Packed with desiccant.

Manufactured for: TEVA PHARMACEUTICALS USA Sellersville, PA 18960 USA

Manufactured in Canada by: Valeant Pharmaceuticals International, Inc. Steinbach, MB R5G 1Z7 Canada

LB0013-05 Rev. 06/2011

PRINCIPAL DISPLAY PANEL - 30 mg Bottle Label

NDC 0093- 0819 -01

Nifedical XL ® (NIFEDIPINE) Extended-release Tablets, USP* 30 mg

PRINCIPAL DISPLAY PANEL - 60 mg Bottle Label

NDC 0093- 5173 -01

Nifedical XL ® (NIFEDIPINE) Extended-release Tablets, USP* 60 mg

Rivodaron 200, Rivodaron

Rivodaron 200

Composition

Amiodaroni hydrochloridum 200 mg in 1 tablet

Pharmacotherapeutic group

Antiarrhythmic agent (ATC code: C01BD01)

Therapeutic indications

Disorders in atrial rhythm (version of fibrillation or flutter, maintenance of the sinus rhythm after cardioversion), nodal disorders in rhythm – tachycardia, ventricular disorders in rhythm (life-threatening premature contractions of the ventricles, ventricular tachycardias in volleys, prevention of fits of ventricular tachycardia and ventricular fibrillation), disorders in the rhythm associated with Wolff?Parkinson?White syndrome. Amiodarone is indicated particularly in the cases when the above-mentioned disorders in rhythm are accompanied by other cardiac diseases (coronary insufficiency, cardiac failure). The preparation is intended for the therapy of adults.

Pharmacological properties

Amiodarone belongs to Vaughan Williams Class III. It acts as a potassium channels blocker, noncompetitive alpha - and beta?adrenergic inhibitor, feebly blocking also calcium channels. It decelerates the sinoatrial, atrial and nodal conduction, and does not influence intraventricular conduction. It prolongs the refractory period and decreases the excitability of the myocardium at the atrial, nodal as well as ventricular level.

Pharmaceutical form

Posology and method of administration

The usual initial dose is 600 mg daily divided into 3 partial doses for a period of 8 to 10 days. The dose may be increased up to 1,200 mg. The dose for maintenance treatment must be determined according to the individual response. It usually ranges between 100 to 400 mg daily. Tablets may be swallowed regardless of food.

Contraindications

Sinus bradycardia and sinoatrial blocks. Sick sinus syndrome and A?V blocks of a higher degree, if the patient has not got a pacemaker (risk of sinus arrest). Thyroidal dysfunction. Hypersensitivity to iodine or substances contained in the product. Combined therapy with drugs which may cause “torsades de pointes.” Lactation. With regard to its iodine content, in pregnancy the preparation should be administered only if strictly necessary and for the shortest time possible.

Interactions

Concomitant administration of amiodarone and chinidin, sotalol, intravenously administered erythromycin, or the drugs inducing hypokalemia (diuretics, systemic corticoids, amphotericin B) may develop serious disorders in the rhythm up to the “torsades de pointes” type. Bradycardia and disorders in transfer may take place in combination with beta-blockers, some calcium channel blockers (verapamil, diltiazem) and general anaesthetics. Amiodarone potentiates the effect of oral anticoagulant agents and increases plasmatic levels of digoxin, phenytoin and cyclosporine.

Undesirable effects

Proarrhythmic effects are infrequent, in dependence on the dose symptomatic bradycardia may occur. Amiodarone is deposited into the cornea, inhibits conversion of thyroxin to triiodothyronine (due to the presence of iodine in the molecule), produces photosensitisation, peripheral neuropathy, interstitial pneumonitis, headaches, sleep disorders, nausea, constipation and other gastrointestinal difficulties.

Special warnings and precautions for use

It is necessary to avoid sunlight during therapy.

The medicinal product is available on prescription only and is partly covered by health insurance.

Croton Oil Peel - Eberbach Plastic Surgery Eberbach Plastic Surgery, Crotanol

Home » Croton Oil Peel

Croton Oil Peel

Do you want to take your skin back to how it looked 15-20 years ago? Then the croton oil peel may be for you! The croton oil peel (also called modified phenol peel or Hetter peel) is a chemical treatment that penetrates deeply into the skin. The croton oil peel is a specially formulated peel based on recent publications and research. The procedure is performed under general anesthesia or local anesthesia (your choice) in our office by Dr. Eberbach. The croton oil peels require 10-14 days of recovery depending on the depth of the peel. The modified peel can be done on the entire face for an overall skin rejuvenation, or only in localized areas such as under the eyes for “creepy” lower lids or around the mouth to remove the vertical smoker’s lines. Localized peri-oral peels can be done, peeling to a medium depth at most. An excellent location for segmental peeling is the eyelids.

Advantages:

Tighter skin—Following this peel, patients also will show between 25 – 30% facial skin tightening.

Less age spots and pigmentation problems

Less wrinkles around the mouth, crow’s feet, forehead furrows and cheeks. The Croton oil peels are impressive for peri-oral wrinkles (those around the mouth) and of the lower eyelids. These areas can be done isolated with much less recovery time.

Face Procedures

Rispecare, Rispecare

Respicare DME, Inc.

The Sleep Wellness Center

Welcome to Respicare DME, Inc.

Respicare DME, Inc. is a privately owned company dedicated to providing homecare patients with the highest quality healthcare equipment and services. We specialize in rental, sale, and supplies for Obstructive Sleep Apnea Syndrome (OSAS).

Respicare DME, Inc. prides itself on its highly motivated and carefully trained homecare professionals. Collectively we bring over 50 years of Respiratory Therapy and Sleep Services to our patients. Our staff understands your every need and we respond to them in a professional and friendly manner. Our staff includes; Customer service representatives, Registered Respiratory Therapist, Registered Sleep Technologist, Business Development and Billing/Insurance services. We employ the true TEAM environment for all of our patients.

Respicare DME, Inc. we accept patients whose healthcare can be properly met by the services we offer and by the area we serve. The service areas include the Research Triangle and the Piedmont Triad of North Carolina. A partial listing of the services that we provide includes:

Respiratory Equipment and Supplies

PAP Therapy Equipment Set-up and one-on-one patient instruction

We are pleased that you have chosen Respicare DME, Inc. You can be assured that through caring, concern, and dedication we strive to achieve the highest quality of life for the patients that we serve. Our company mission and vision is to “Changing the landscape of Sleep, one community at a time” .

We appreciate your business!

Michael and Kristi Fox

Accreditation

Insurance

Preclinical & Clinical Data – Pharmapendium, Pendium

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Challenges are inevitable on the path to regulatory approval of drug candidates. Successful drug development involves anticipating those challenges as early as possible. Comparative and up-to-date information is needed to verify pharmacokinetic and experimental data, anticipate species-specific issues in translating in vitro and in vivo studies, predict potential drug–drug interactions and design clinical trial studies to best preclude regulatory issues.

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A well-informed, well-structured preclinical safety workflow needs to be thorough both in terms of information sources and methodology. Using PharmaPendium, Dr. William B. Mattes takes an in-depth look at the preclinical workflow for drug safety analysis, assessing the elements that are critical for best impact.

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Bazetham Mr (Tamsulosin), Bazetham

Bazetham MR (tamsulosin)

What is it used for?

Relieving the urinary symptoms of an enlarged prostate gland (benign prostatic hyperplasia or BPH), for example needing to pass urine frequently or urgently, but having a weak flow of urine or being unable to fully empty the bladder when you do go.

How does it work?

Bazetham MR capsules contain the active ingredient tamsulosin hydrochloride, which is a type of medicine called an alpha blocker. Tamsulosin capsules are also available without a brand name, ie as the generic medicine. Tamsulosin works by blocking alpha receptors that are found in the muscle in the prostate gland.

The prostate gland, which is found only in men, lies at the top of the tube connecting the bladder to the outside (urethra). The prostate gland often enlarges with advancing age (benign prostatic hyperplasia), pressing on the urethra and obstructing the flow of urine from the bladder. This can cause various urinary symptoms, such as difficulty passing urine, being unable to completely empty the bladder and needing to pass urine more often or urgently.

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Tamsulosin works by blocking alpha receptors that are found in the muscle in the prostate gland. This action causes the muscle in the prostate to relax, which relieves pressure on the urethra and allows urine to flow freely past the prostate gland. This makes it easier to pass urine and empty the bladder.

Bazetham MR are 'modified-release' capsules. They are designed to release the tamsulosin gradually as they pass through the stomach and intestine, so that a steady amount of medicine is absorbed into the bloodstream throughout the day despite the medicine only being taken once a day. The capsules must be swallowed whole and must not be chewed, broken or crushed, as this would stop the modified-release action from working.

How do I take it?

One Bazetham MR capsule should be taken once a day at the same time each day, preferably after breakfast.

The capsule should be swallowed whole with a glass of water and not opened, crushed or chewed.

If you forget to take a dose at your usual time, take it as soon as you remember. However, if you have forgotten to take a dose for a whole day don't worry, just leave out the missed dose and take your next dose as usual when it is due. Don't take a double dose to make up for a missed dose.

Keep taking this medicine every day unless your doctor tells you to stop. Stopping treatment is likely to make your urinary symptoms come back.

Warning!

This medicine may cause dizziness, light-headedness and on rare occasions fainting. Take care when moving from a lying down or sitting position to sitting or standing, particularly if you wake up in the night, until you know how this medicine affects you. If you feel dizzy or light-headed at any time during treatment, sit or lie down until the symptoms pass.

This medicine may cause drowsiness, dizziness or blurred vision and so may affect your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.

This medicine does not cause prostate cancer, but prostate cancer can be another cause of an enlarged prostate gland. For this reason, tests for prostate cancer should be carried out before you start treatment with this medicine, and at regular intervals thereafter. One test that can be carried out is a digital rectal examination (DRE), to check if the prostate gland is enlarged. The other is to measure the level of prostate specific antigen (PSA) in the blood. An increase in the PSA levels may mean that the prostate gland is enlarged.

If you are scheduled to have eye surgery for cataracts it is important to let your eye specialist know if you are or have been taking this medicine. This is because tamsulosin can make your pupil dilate poorly and the iris (the coloured circular part of the eye) become floppy during the procedure. The specialist needs to know if you have been taking this medicine so they can take appropriate precautions with the medicines and techniques they use during the surgery. You may be asked to stop taking this medicine for a period of time before cataract surgery. Check with your doctor.

Use with caution in

People with severely decreased kidney function.

Not to be used in

People with a history of drops in blood pressure that cause dizziness when getting up from sitting or lying down (postural hypotension).

People with severely decreased liver function.

This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Common (affect between 1 and 10 out of every 100 people)

Dizziness - see warning section above.

Abnormal ejaculation.

Uncommon (affect between 1 and 10 out of every 1000 people)

Headache.

Awareness of your heartbeat (palpitations).

Feeling weak.

A drop in blood pressure that occurs when moving from lying down to sitting or standing, which results in dizziness and lightheadedness (postural hypotension) - see warning section above.

Inflammation of the lining of the nose (rhinitis) causing a blocked or runny nose.

Disturbances of the gut such as diarrhoea, constipation, nausea or vomiting.

Skin reactions such as rash and itch.

Rare (affect between 1 and 10 out of every 10,000 people)

Fainting (syncope).

Swelling of the face, throat and tongue (angioedema). Get medical assistance straight away if you experience this.

Very rare (affect fewer than 1 in 10,000 people)

Persistent painful erection of the penis (priapism ).

Severe blistering skin reaction affecting the tissues of the eyes, mouth, throat and genitals (Stevens-Johnson Syndrome).

Unknown frequency

Drowsiness.

Blurred vision.

Impaired vision.

Dry mouth.

Nosebleeds.

Faster than normal or irregular heartbeat.

Shortness of breath.

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to make sure that the combination is safe .

If this medicine is taken with medicines that can reduce blood pressure, this effect may be enhanced, with an increased chance of dizziness or fainting. Other medicines that may reduce blood pressure include the following. If you take any of these with this medicine let your doctor know if you feel very dizzy:

The following medicines may increase the level of tamsulosin in the blood by interfering with its breakdown by the body. If you take any of these with this medicine let your doctor know if you experience any new or increased side effects of tamsulosin, eg dizziness:

Other medicines containing the same active ingredient

Tamsulosin modified-release capsules are also available without a brand name, ie as the generic medicine.

Combodart contains tamsulosin in combination with another medicine called dutasteride.

Vesomni contains tamsulosin in combination with another medicine called solifenacin.

Last updated 28.10.2014

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Prometazina Medlineplus Medicinas, Prometazina

Prometazina

Advertencia:

La prometazina puede hacer que la respiracion sea mas lenta o se detenga, y eso puede ocasionarles la muerte a los ninos. La prometazina no se les debe dar a bebes ni a ninos menores de 2 anos, y se debe usar con precaucion en los ninos de 2 anos en adelante. Los productos mixtos que contienen codeina y prometazina no se les deben dar a ninos menores de 16 anos de edad. La prometazina no debe usarse de modo rutinario para tratar el vomito en los ninos; unicamente se debe usar en casos especificos si el medico la considera necesaria. Digale al pediatra de su hijo si tiene algun problema que le afecte la respiracion, como una enfermedad pulmonar, asma o apnea del sueno (deja de respirar por corto tiempo cuando esta dormido). Digales a su medico o a su farmaceutico todos los medicamentos que el nino este tomando, en especial barbituricos como fenobarbital (Luminal), medicamentos contra la ansiedad, analgesicos narcoticos, sedantes, pastillas para dormir y tranquilizantes. Llame de inmediato al pediatra del nino y busque tratamiento medico de emergencia si el nino tiene dificultad para respirar, sibilancia, respiracion lenta o con pausas, o deja de respirar.

Consulte a su medico sobre los riesgos de darle prometazina a su hijo.

?Para cuales condiciones o enfermedades se prescribe este medicamento?

La prometazina se usa para aliviar los sintomas de reacciones alergicas como la rinitis alergica (secrecion nasal y lagrimeo de ojos causados por la alergia al polen, al moho o al polvo), conjuntivitis alergica (enrojecimiento, lagrimeo de ojos causados por las alergias), reacciones alergicas de la piel, y reacciones alergicas a la sangre o los derivados del plasma sanguineo. La prometazina se usa con otros medicamentos para tratar la anafilaxia (reacciones alergicas subitas e intensas) y los sintomas del resfriado comun, como estornudos, tos y secrecion nasal. La prometazina tambien se usa para relajar y sedar a los pacientes antes y despues de la cirugia, durante el trabajo de parto y en otras ocasiones. Ademas, la prometazina se usa para prevenir y controlar las nauseas y los vomitos que pueden presentarse despues de una cirugia, y con otros medicamentos para ayudar a aliviar el dolor despues de la cirugia. Otro uso de la prometazina es para la prevencion y el tratamiento del mareo por movimiento. La prometazina ayuda a controlar los sintomas, pero no trata la causa de los mismos ni acelera la recuperacion. La prometazina pertenece a una clase de medicamentos llamados fenotiazinas. Actua al bloquear la accion de una sustancia natural del cuerpo.

?Como se debe usar este medicamento?

La prometazina se presenta en forma de tabletas y jarabe (liquido) para administrarse por via oral, y de supositorios rectales. Cuando la prometazina se usa para tratar alergias, por lo general se toma de una a cuatro veces al dia, antes de las comidas y/o a la hora de acostarse. Cuando se usa prometazina para aliviar los sintomas del resfriado, por lo comun se toma cada 4 a 6 horas, segun sea necesario. Cuando se usa prometazina para tratar el mareo por movimiento, se toma entre 30 y 60 minutos antes del viaje, y nuevamente en 8 a 12 horas, de ser necesario. En los viajes mas largos, la prometazina suele tomarse por la manana, y nuevamente antes de la cena, en cada dia de viaje. Cuando se usa prometazina para tratar o prevenir las nauseas y los vomitos, por lo comun se toma cada 4 a 6 horas, segun sea necesario. La prometazina tambien se puede tomar a la hora de acostarse, la noche previa a la cirugia, para aliviar la ansiedad y dormir tranquilamente. Siga atentamente las instrucciones de la etiqueta de la receta y pidales a su medico o a su farmaceutico que le expliquen cualquier cosa que no entienda. Tome la prometazina segun lo indicado. No aumente ni disminuya la dosis, ni la tome con mas frecuencia que la indicada por su medico.

Los supositorios de prometazina son exclusivamente para uso rectal. No intente tragarse los supositorios ni introducirlos en alguna otra parte del cuerpo.

Si esta tomando prometazina liquida, no use una cuchara de cocina para medir la dosis. Use la cuchara o la taza medidora que viene con el medicamento, o use una cuchara disenada especialmente para medir medicamentos.

Para aplicar un supositorio de prometazina en el recto, siga estos pasos:

Lavese muy bien las manos con agua y jabon.

Si el supositorio esta blando, coloquelo bajo el chorro de agua fria o pongalo en el refrigerador unos minutos para endurecerlo antes de quitarle la envoltura.

Quite la envoltura, si la hubiera.

Si le dijeron que usara medio supositorio, partalo a lo largo con un cuchillo limpio y bien afilado.

Si lo desea, pongase una funda para dedo o un guante desechable (puede adquirirlos en la farmacia).

Lubrique la punta del supositorio con un lubricante soluble en agua, como K-Y Jelly, no use vaselina (Vaseline). Si no tiene este lubricante, humedezca la region anal con agua fria del grifo.

Acuestese sobre un costado, con la pierna de abajo extendida y la pierna de arriba flexionada hacia el estomago.

Levante el gluteo de arriba para exponer la region anal.

Introduzca el supositorio por el extremo puntiagudo y empujelo con el dedo hasta que pase el esfinter muscular del recto, aproximadamente entre media y 1 pulgada (1.25 a 2.5 centimetros) en los bebes, y 1 pulgada (2.5 centimetros) en los adultos. Si el supositorio no pasa el esfinter, puede salirse.

Apriete los gluteos por unos segundos.

Permanezca acostado durante aproximadamente 15 minutos para impedir que el supositorio se salga.

Trate de no defecar durante mas o menos una hora para que el organismo pueda absorber el medicamento del supositorio.

Deseche los materiales usados y lavese muy bien las manos.

?Que otro uso se le da a este medicamento?

A veces se receta este medicamento para otros usos; pidales mas informacion a su medico o a su farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes de usar la prometazina,

digales a su medico y a su farmaceutico si es alergico a la prometazina, a otras fenotiazinas (ciertos medicamentos que se usan para tratar las enfermedades mentales, la nausea, el vomito, el hipo intenso y otras afecciones) o a cualquier otro medicamento. Digales tambien a su medico y a su farmaceutico si ha tenido alguna reaccion anormal o inesperada al tomar prometazina, otra fenotiazina u otros medicamentos. Pregunteles a su medico o a su farmaceutico cuando no sepa si un medicamento al que es alergico es una fenotiazina.

digales a su medico y a su farmaceutico que medicamentos con y sin receta, vitaminas, suplementos nutricionales y productos herbales esta tomando o piensa tomar. No olvide mencionar ninguno de los siguientes: antidepresivos ('elevadores del estado de animo') como amitriptilina (Elavil), amoxapina (Asendin), clomipramina (Anafranil), desipramina (Norpramin), doxepina (Adapin, Sinequan), imipramina (Tofranil), nortriptilina (Aventyl, Pamelor), protriptilina (Vivactil) y trimipramina (Surmontil); antihistaminicos; azatioprina (Imuran); barbituricos como fenobarbital (Luminal); la quimioterapia contra el cancer; epinefrina (Epipen); ipratropio (Atrovent) medicamentos para la ansiedad, el sindrome de intestino irritable, la enfermedad mental, el mareo por movimiento, la enfermedad de Parkinson, las crisis convulsivas, las ulceras, o los problemas urinarios; inhibidores de la monoamino oxidasa (MAO) como isocarboxazid (Marplan), fenelzina (Nardil), tranilcipromina (Parnate) y selegilina (Eldepryl, Emsam, Zelapar); opiaceos y otros analgesicos; sedantes; pildoras para dormir y tranquilizantes. Es posible que su medico deba cambiar la dosis de sus medicamentos o vigilarle estrechamente por si presentara efectos secundarios.

digale a su medico si tiene o ha tenido agrandamiento de la prostata (una glandula reproductora masculina); glaucoma (padecimiento en el que el aumento de la presion del ojo puede ocasionar la perdida gradual de la vision); convulsiones; ulceras; obstruccion del conducto que comunica el estomago y el intestino; obstruccion de la vejiga urinaria; asma u otra enfermedad pulmonar; apnea del sueno; cancer;cualquier padecimiento que afecte la produccion de celulas sanguineas en la medula osea; o alguna enfermedad del corazon o del higado. Antes de darle prometazina a un nino, tambien digale al pediatra del nino si este tiene alguno de los siguientes sintomas: vomitos, languidez, somnolencia, confusion, agresividad, convulsiones, coloracion amarillenta en la piel o los ojos, debilidad o sintomas parecidos a los de la gripe. Digale tambien al pediatra del nino si este no ha bebido liquidos normalmente, si ha tenido vomitos o diarrea en exceso, o si parece estar deshidratado.

digale a su medico si esta embarazada o planea quedar embarazada o si esta amamantando. Si queda embarazada mientras esta tomando prometazina, llame a su medico.

hable con su medico sobre los riesgos y beneficios de tomar prometazina si usted tiene 65 anos de edad o mas. Los adultos mayores por lo general no deben tomar dosis altas de prometazina ya que no es tan seguro como otros medicamentos que pueden usarse para tratar la misma condicion.

si le van a hacer alguna cirugia, incluso una cirugia dental, digales al medico o al dentista que esta tomando prometazina.

tenga en cuenta que este medicamento puede causarle somnolencia. Evite conducir vehiculos u operar maquinarias hasta que sepa como le afecta este medicamento. Si le esta dando prometazina a un nino, vigilelo para asegurarse de que no se lastime mientras monta en bicicleta o participa en otras actividades que pudieran ser peligrosas.

preguntele a su medico si es prudente beber alcohol mientras este tomando prometazina. El alcohol puede empeorar los efectos secundarios de la prometazina.

evite la exposicion innecesaria o prolongada a la luz solar y protejase con ropa, anteojos de sol y protector solar. La prometazina puede hacer que la piel se vuelva sensible a la luz solar.

?Que dieta especial debo seguir mientras tomo este medicamento?

A menos que su medico le indique lo contrario, continue con su dieta normal.

?Que tengo que hacer si me olvido de tomar una dosis?

Si olvida tomar una dosis, tomela en cuanto se acuerde. No obstante, si ya casi es hora de la dosis siguiente, deje pasar la que olvido y continue con su horario de medicacion normal. No tome una dosis doble para compensar la que olvido.

?Cuales son los efectos secundarios que podria provocar este medicamento?

La prometazina puede provocar efectos secundarios. Avisele a su medico si cualquiera de estos sintomas es grave o no desaparece:

boca seca

somnolencia

falta de energia

dificultad para dormirse o permanecer dormido

pesadillas

mareos

zumbido en los oidos

vision borrosa o doble

perdida de coordinacion

nauseas

vomitos

nerviosismo

intranquilidad

hiperactividad

estado de animo demasiado euforico

congestion nasal

comezon

Algunos efectos secundarios pueden ser graves. Si presenta alguno de estos sintomas, llame a su medico de inmediato:

sibilancia

respiracion lenta

interrupcion de la respiracion por poco tiempo

fiebre

sudoracion

rigidez muscular

disminucion del estado de alerta

latidos del corazon rapidos o irregulares

desvanecimiento

movimientos anormales o incontrolables

alucinaciones (ver cosas o escuchar voces que no existen)

confusion

emociones o temores agobiantes o fuera de control

convulsiones

temblor incontrolable de alguna parte del cuerpo

hemorragias o moretones inusuales

dolor de garganta, fiebre, escalofrios y otros signos de infeccion

movimientos incontrolables de los ojos

lengua que asoma fuera de la boca

posicion anormal del cuello

incapacidad para responderles a quienes le rodean

coloracion amarillenta en la piel o los ojos

sarpullido

urticaria

hinchazon de los ojos, la cara, los labios, la lengua, la garganta, los brazos, las manos, los pies, los tobillos o las pantorrillas

ronquera

dificultad para respirar o tragar

Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgacion de efectos adversos 'MedWatch' de la Administracion de Alimentos y Medicamentos (FDA, por su sigla en ingles) en la pagina de Internet (http://www. fda. gov/Safety/MedWatch ) o por telefono al 1-800-332-1088.

La prometazina puede provocar otros efectos secundarios. Llame a su medico si tiene algun problema inusual mientras toma este medicamento.

?Como debo almacenar o desechar este medicamento?

Mantenga este producto en su caja o envase original, perfectamente cerrado y fuera del alcance de los ninos. Guarde las tabletas y el jarabe de prometazina a temperatura ambiente, y en un lugar alejado del exceso de calor y humedad (nunca en el cuarto de bano). Guarde los supositorios de prometazina en el refrigerador. Proteja este medicamento de la luz. Deseche todos los medicamentos que esten vencidos o que ya no necesite. Preguntele a su farmaceutico cual es la manera adecuada de desechar los medicamentos.

?Que debo hacer en caso de una sobredosis?

En caso de una sobredosis, llame a la oficina local de control de envenenamiento al 1-800-222-1222. Si la victima esta inconsciente, o no respira, llame inmediatamente al 911.

Los sintomas de sobredosis son, entre otros:

dificultad para respirar

respiracion lenta o interrupcion de la respiracion

mareos

aturdimiento

desvanecimiento

perdida del conocimiento

latidos del corazon rapidos

musculos tensos y dificiles de mover

perdida de coordinacion

movimientos continuos de retorcimiento de las manos y los pies

boca seca

pupilas dilatadas (grandes circulos negros en el centro de los ojos)

ruborizacion

nauseas

estrenimiento

agitacion o nerviosismo anormal

pesadillas

?Que otra informacion de importancia deberia saber?

No falte a ninguna cita con su medico.

La prometazina puede alterar los resultados de las pruebas de embarazo en el hogar. Consulte a su medico si cree que pudiera estar embarazada mientras esta tomando prometazina. No se haga pruebas de embarazo en casa.

Antes de hacerse cualquier prueba de laboratorio, digales a su medico y al personal del laboratorio que esta tomando prometazina.

No deje que ninguna otra persona use sus medicamentos. Preguntele a su farmaceutico como puede volver a surtir su receta.

Es importante que Ud. mantenga una lista escrita de todas las medicinas que Ud. esta tomando, incluyendo las que recibio con receta medica y las que Ud. compro sin receta, incluyendo vitaminas y suplementos de dieta. Ud. debe tener la lista cada vez que visita su medico o cuando es admitido a un hospital. Tambien es una informacion importante en casos de emergencia.

Marcas comerciales

Bisocor 5mg Tablets - Piersbaldridge S Blog, Bisocor

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Pozole Rojo, Red Posole, Ozole

Posole Rojo

Photography Credit: Elise Bauer

Years ago when I spent a summer studying Spanish in Cuernavaca, Mexico, my Mexican teacher told me that it was much easier to pronounce the language properly if you smiled as you spoke it. She was right! Good thing Mexican food is so delicioso . because just thinking about dishes like this posole makes me smile.

It’s somewhat of a feast, posole. I guess you could make smaller batches, but since you have to cook it for several hours, it just makes sense to make a large amount, and then have lots of friends over with whom to enjoy it. Posole (or pozole) is a traditional soup in Mexico, often served Christmas eve, and in many parts of the country on Thursdays and Saturdays all year round.

This posole rojo, or “red” posole, is made with pork shoulder or shanks, red chiles, and lots of hominy corn. I made this for my parents, and they loved it. Mom told me she hadn’t had posole since she was a kid in Tucson. Lots of smiley faces around the table tonight.

Typically just the simple soup with pork and hominy is served, and the add-ins, or garnishes are set at the table for all to pick and put in their soup as they wish. The soup itself should be rather thin, or brothy, because you are going to load it up quickly with shredded cabbage, thinly sliced radishes, chopped avocados, cilantro, onions, and wedges of lime.

More hot sauce or chiles can be added for more heat. Posole is all about the garnishes. So good! Many thanks to my good friend Arturo from Guerrero Mexico for showing me how to make this wonderful soup.

Posole Rojo Recipe

Prep time: 30 minutes

Cook time: 3 hours

Yield: Serves 12, plus plenty for leftovers.

We haven't made this in a slow cooker, but I'm guessing that step 6 could easily be done in a slow cooker.

Ingredients

4 ounces guajillo, ancho, or a combination of both, chili pods

Salt

1 large (108 ounce, 6 lb 12 oz, 3 kg) can white hominy, drained and rinsed

3 lbs pork shoulder (preferably with bone), cut into 1 to 1 1/2 inch cubes (can also use pork shanks), make sure to use a cut well marbled with fat

8 cloves garlic, 4 cloves roughly chopped, and 4 whole cloves

3 bay leaves

1 teaspoon ground cumin

2 Tbsp of dry oregano (Mexican oregano if available)

Garnishes (can prep while pozole is cooking):

Half a small cabbage, thinly sliced

One bunch cilantro, chopped

1/2 white onion, chopped

2 avocados, chopped

4 limes, quartered

A bunch of red radishes, sliced thin

A couple dozen tostada shells*

*Tostadas are crispy fried corn tortillas. They are sold packaged and can often be found in the same section of your grocery store as fresh tortillas, or can be found at Mexican markets. You can make your own by frying stale corn tortillas (or tortillas that have dried out a bit in a warm oven), in hot vegetable oil until stiff.

Method

1 Fill a large 10-12 quart stockpot with 5 quarts of water. Set on heat to bring to a boil while you proceed with the next steps.

2 Remove and discard the stems, seeds, and large veins from the chili pods. Heat a cast iron pan on medium high and lightly roast the chili pods for a couple minutes, until they begin to soften. Do not let them burn. While the chilies are heating, bring a medium pot with 3 cups of water to a boil. Once the chiles have softened, submerge them in the pot with the 3 cups of hot water, cover the pot and remove from heat. Let the chiles soak in the hot water for 15 to 20 minutes.

3 Heat a tablespoon or two of olive oil (enough to coat the bottom of the pan) in a large saute pan on medium high heat. Pat the pork pieces dry with paper towels. Sprinkle them generously with salt. Working in batches, taking care not to crowd the pan or stir the meat much, brown the meat on all sides. Right at the end of browning the meat, add 4 cloves of roughly chopped garlic to the pan with the meat, let cook with the meat for about a minute.

4 Once the meat has browned, transfer it to the large stockpot of boiling water. Scrape up any browned bits at the bottom of the pan, and any garlic, and add those to the pot as well. Add the rinsed hominy. Add bay leaves, cumin, and oregano. When you put the oregano in, smoosh together with your hands so that the oregano breaks up more as it goes in. Add a tablespoons of salt. Bring to a simmer, reduce the heat and cook for 15 minutes.

5 Prepare the red sauce by pureeing in a blender the chilies, 2 1/2 cups or so of their soaking liquid, a teaspoon of salt, and 4 cloves of garlic. (To prevent the blender from creating too much pressure, it's probably best to start with the chiles and garlic and only a cup of the liquid in the blender, and then adding the rest of the liquid.) Strain the red sauce through a sieve, discarding the tough bits of the sauce.

6 Add the red chili sauce to the pot with the pork and hominy. Add another couple teaspoons of of salt. Return to a simmer, lower the heat to just high enough to maintain a simmer, partially covered. Cook for 2-3 hours until the pork is completely tender. Skim away excess fat. Taste for seasoning and add more salt to taste (you will likely need more than you expect, perhaps a tablespoon or more.) The resulting soup should be rather brothy, as you will be adding a lot garnishes. Add more water if necessary.

7 When getting ready to serve the pozole, you can prep the garnishes (slice the cabbage, chop the cilantro, etc.) To serve, arrange the garnishes in bowls on the table and serve the pozole soup into bowls. Let your guests pick and choose which garnishes they would like on their pozole. Serve with tostada shells (or tortilla chips if you can't find tostada shells).

Hello! All photos and content are copyright protected. Please do not use our photos without prior written permission. If you wish to republish this recipe, please rewrite the recipe in your own unique words and link back to Posole Rojo on Simply Recipes. Thank you!

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Showing 4 of 57 Comments

I have been making this recipe for over a year now and it is the best! Im going to be sad to put this recipe away for the summer so I’m going to make it one more time before the heat comes. Thank you for sharing!

March 25, 2016

Delsey Kinnard

Back in the day when you had eleven siblings in the house you knew your mama had to make every dinner stretch, mom would also cook up a pot of pinto beans and add them into the pozole, the broth/juice from the beans also brought on a rich thick flavor as well. My mothers recipe lives on in our family.

I am Mexican and was looking for a traditional recipe (didn’t want to ask relatives) and your recipe is the most authentic I found, it is so delicious thank you for your contribution my husband especially thanks you

When you said “red posole,” I thought you meant you were using red corn! I think the sauce from the chilies must be really tasty. I want to try this. I have dried red posole corn kernels that I want to use, so this will be perfect for the soup. Wonderful recipe!

My girlfriend and I have been looking for a Mexican restaurant in our area to have this dish, only to find that the places we tried didn’t serve it so we decided to try and make it. Well we came across your recipe and gave it a try. It came out fantastic. We are Hispanic and proud to serve this to our families. Thank you so much.

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Confortid

Confortid - General Information

A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.

Pharmacology of Confortid

Confortid, a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.

Confortid for patients

Indomethacin, like other drugs of its class, is not free of side effects. The side effects of these drugs can cause discomfort and rarely, there are more serious side effects, such as gastrointestinal bleeding, which may result in hospitalization and even fatal outcomes. NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) are often essential agents in the management of arthritis. but they also may be commonly employed for conditions which are less serious. Physicians may wish to discuss with their patients the potential risks and likely benefits of NSAID treatment, particularly when the drugs are used for less serious conditions where treatment without NSAIDs may represent an acceptable alternative to both the patient and physician.

Confortid Interactions

In normal volunteers receiving indomethacin, the administration of diflunisal decreased the renal clearance and significantly increased the plasma levels of indomethacin. In some patients, combined use of INDOCIN and diflunisal has been associated with fatal gastrointestinal hemorrhage. Therefore, diflunisal and INDOCIN should not be used concomitantly.

In a study in normal volunteers, it was found that chronic concurrent administration of 3.6 g of aspirin per day decreases indomethacin blood levels approximately 20%.

The concomitant use of INDOCIN with other NSAIDs is not recommended due to the increased possibility of gastrointestinal toxicity, with little or no increase in efficacy.

Clinical studies have shown that INDOCIN does not influence the hypoprothrombinemia produced by anticoagulants. However, when any additional drug, including INDOCIN, is added to the treatment of patients on anticoagulant therapy, the patients should be observed for alterations of the prothrombin time. In post-marketing experience, bleeding has been reported in patients on concomitant treatment with anticoagulants and INDOCIN. Caution should be exercised when INDOCIN and anticoagulants are administered concomitantly.

When INDOCIN is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased. Therefore, a lower total daily dosage of INDOCIN may produce a satisfactory therapeutic effect. When increases in the dose of INDOCIN are made, they should be made carefully and in small increments.

Caution should be used if INDOCIN is administered simultaneously with methotrexate. INDOCIN has been reported to decrease the tubular secretion of methotrexate and to potentiate its toxicity.

Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin. NSAIDs should be used with caution in patients taking cyclosporine, and renal function should be carefully monitored.

Capsules INDOCIN 50 mg t. i.d. produced a clinically relevant elevation of plasma lithium and reduction in renal lithium clearance in psychiatric patients and normal subjects with steady state plasma lithium concentrations. This effect has been attributed to inhibition of prostaglandin synthesis. As a consequence, when INDOCIN and lithium are given concomitantly, the patient should be carefully observed for signs of lithium toxicity. (Read circulars for lithium preparations before use of such concomitant therapy.) In addition, the frequency of monitoring serum lithium concentration should be increased at the outset of such combination drug treatment.

INDOCIN given concomitantly with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. Therefore, when INDOCIN and digoxin are used concomitantly, serum digoxin levels should be closely monitored.

In some patients, the administration of INDOCIN can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Therefore, when INDOCIN and INDOCIN. (Indomethacin) diuretics are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

INDOCIN reduces basal plasma renin activity (PRA), as well as those elevations of PRA induced by furosemide administration, or salt or volume depletion. These facts should be considered when evaluating plasma renin activity in hypertensive patients.

It has been reported that the addition of triamterene to a maintenance schedule of INDOCIN resulted in reversible acute renal failure in two of four healthy volunteers. INDOCIN and triamterene should not be administered together.

INDOCIN and potassium-sparing diuretics each may be associated with increased serum potassium levels. The potential effects of INDOCIN and potassium-sparing diuretics on potassium kinetics and renal function should be considered when these agents are administered concurrently.

Most of the above effects concerning diuretics have been attributed, at least in part, to mechanisms involving inhibition of prostaglandin synthesis by INDOCIN.

Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by non-steroidal antiinflammatory drugs including INDOCIN has been reported. Therefore, when using these blocking agents to treat hypertension, patients should be observed carefully in order to confirm that the desired therapeutic effect has been obtained. INDOCIN can reduce the antihypertensive effects of captopril and losartan.

False-negative results in the dexamethasone suppression test (DST) in patients being treated with INDOCIN have been reported. Thus, results of the DST should be interpreted with caution in these patients.

Confortid Contraindications

Indomethacin should not be used in:

Patients who are hypersensitive to this product.

Patients in whom acute asthmatic attacks, urticaria, or rhinitis are precipitated by aspirin or other nonsteroidal anti - inflammatory agents.

Suppositories INDOCIN are contraindicated in patients with a history of proctitis or recent rectal bleeding.

Additional information about Confortid

Confortid Indication: For moderate to severe rheumatoid arthritis including acute flares of chronic disease, ankylosing spondylitis. osteoarthritis. acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis. Mechanism Of Action: Antiinflammatory effects of Confortid are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Drug Interactions: Acebutolol Risk of inhibition of renal prostaglandins Atenolol Risk of inhibition of renal prostaglandins Betaxolol Risk of inhibition of renal prostaglandins Bevantolol Risk of inhibition of renal prostaglandins Bisoprolol Risk of inhibition of renal prostaglandins Carteolol Risk of inhibition of renal prostaglandins Carvedilol Risk of inhibition of renal prostaglandins Methotrexate The NSAID increases the effect and toxicity of methotrexate Diflunisal Diflunisal increases the effect and toxicity of indomethacin Esmolol Risk of inhibition of renal prostaglandins Labetalol Risk of inhibition of renal prostaglandins Metoprolol Risk of inhibition of renal prostaglandins Nadolol Risk of inhibition of renal prostaglandins Losartan Confortid decreases the effect of losartan Lithium The NSAID increases serum levels of lithium Oxprenolol Risk of inhibition of renal prostaglandins Penbutolol Risk of inhibition of renal prostaglandins Pindolol Risk of inhibition of renal prostaglandins Practolol Risk of inhibition of renal prostaglandins Probenecid Probenecid increases the effect/toxicity of indomethacin Sotalol Risk of inhibition of renal prostaglandins Propranolol Risk of inhibition of renal prostaglandins Timolol Risk of inhibition of renal prostaglandins Warfarin The NSAID increases the anticoagulant effect Acenocoumarol The NSAID increases the anticoagulant effect Dicumarol The NSAID increases the anticoagulant effect Anisindione The NSAID increases the anticoagulant effect Torasemide The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic Bumetanide The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic Furosemide The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic Ethacrynic acid The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic Cyclosporine Monitor for nephrotoxicity Alendronate Increased risk of gastric toxicity Triamterene Risk of acute renal impairment with this combination Food Interactions: Avoid alcohol. Take with food or antacids to reduce irritation. Generic Name: Indomethacin Synonyms: IMN; Indomethacinum; Indomethacine; Indometacyna; Indometacine; Indomethancin; Indomethazine; Indomethine; Indometicina Drug Category: Tocolytic Agents; Cardiovascular Agents; Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs) Drug Type: Small Molecule; Approved; Investigational Other Brand Names containing Indomethacin: Amuno; Apo-Indomethacin; Argun; Arthrexin; Artracin; Artrinovo; Artrivia; Bonidin; Bonidon; Bonidon Gel; Catlep; Chibro-Amuno; Chrono-Indicid; Chrono-Indocid; Confortid; Dolcidium; Dolcidium Pl; Dolovin; Durametacin; Elmetacin; Flexin Continus; Hicin; Idomethine; Imbrilon; Inacid; Indacin; Indameth; Indmethacine; Indo-Lemmon; Indo-Phlogont; Indo-Rectolmin; Indo-Spray; Indo-Tablinen; Indocid; Indocid Pda; Indocid Sr; Indocin; Indocin I. V; Indocin I. V.; Indocin Sr; Indolar Sr; Indomecol; Indomed; Indomee; Indomethegan; Indomo; Indomod; Indoptic; Indoptol; Indorektal; Indoxen; Inflazon; Infrocin; Inteban Sp; Lausit; Liometacen; Metacen; Metartril; Methazine; Metindol; Miametan; Mikametan; Mobilan; Novo-Methacin; Novomethacin; Nu-Indo; Reumacide; Rhemacin La; Rheumacin La; Sadoreum; Tannex; Vonum; Absorption: Bioavailability is approximately 100% following oral administration and 80–90% following rectal administration. Toxicity (Overdose): The following symptoms may be observed following overdosage: nausea, vomiting, intense headache. dizziness. mental confusion, disorientation, or lethargy. There have been reports of paresthesias, numbness, and convulsions. The oral LD 50 of indomethacin in mice and rats (based on 14 day mortality response) was 50 and 12 mg/kg, respectively. Protein Binding: 97% Biotransformation: Hepatic. Half Life: 4.5 hours Dosage Forms of Confortid: Powder, for solution Intravenous Suppository Rectal Capsule Oral Chemical IUPAC Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid Chemical Formula: C19H16ClNO4 Indomethacin on Wikipedia: http://en. wikipedia. org/wiki/Indomethacin Organisms Affected: Humans and other mammals

2017 Solvang Century Metric - Half Century, Solvang Bicycling, Randy Ice, Biscor

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S. C.O. R. which stands for "Specialized Coronary Outpatient Rehabilitation," was founded 1974 by Randy Ice, P. T. C. C.S. We are an incorporated, non-profit recreational bicycling club which encourages bicycling as form of rehabilitative therapy after heart attack, coronary bypass surgery, angioplasty, stents, congestive heart failure and other forms of heart disease.

SCOR members promote safe cycling and emphasize the heath benefits of cycling and related activities. Members sponsor and volunteer at the Solvang Century, Metric and Half Century bike rides. The money we ravtise from these rides supports Camp Bon Couer, Camp del Corazon and Camp Taylor. These are camps for children with unusually severe congenital heart disease who for the first time in their life get to experience summer camping activities in a medically supervised environment with their peers. SCOR has been sponsoring these camps for over 31 years. We also donate to the Tour de Cure American Diabetes Association ride and have done so for many years as well. Our current headquarters is located in Whittier, California. To learn more about becoming a member of SCOR, please call 1 800 548 4447, or visit our website at WWW. SCORCCC. COM

Over the years, we have always emphasized bicycle safety (we were one of the first rides to make helmets mandatory). In fact, our accident rate of one injury per 182,500 person-miles ridden in the last 34 years is lower than the accident rate training where you live, suggesting that you as a rider are safer in our rides despite the number of participants.

The money SCOR has raised has funded four Team SCOR’s in the Race Across America relay division, Make A Wish Foundation, the American Diabetes Association, the AXA World Team Ride and the three children’s congenital heart disease summer camps listed above.

Cyclists Services

Randy Ice, P. T. C. C.S. has many years of experience working with cyclists of all abilities from novice to competitive CAT 1 and RAAM racers. He founded SCOR Cardiac Cyclists Club in 1974 to meet the endurance exercise needs of people with cardiovascular disease. In the early 1980's, Randy began testing and training ultramarathon cyclists for RAAM and currently serves as medical consultant/board member for the Ultramarathon Cycling Association, and Bicycling Magazine, He has written extensively on nutrition, biomechanics and training. Randy is a graduate of USC and is a certified Cardiopulmonary Specialist. He began his cycling injury and analysis program in 1984 out of a need in the cycling community and as a personal interest.

Pro Bike Fit

A bio-mechanically based fitting of the cyclist with his/her bike for the

purpose of preventing or correcting overuse injury, optimizing power

output and or determining optimal frame size. For those in pain while

riding (neck, back, knee, feet etc.) and in depth evaluation will be performed

to determine anatomical, bio-mechanical and or bicycle-related causes:

Recommendations and corrections may include:

Bike fit modifications to achieve correct ergonomic position or to accommodate special orthopedic conditions,

Fabrication of cycling shoe orthotics if needed

Kneesavers to correct Q Factor issues

Shoe and/or cleat buildup for leg length differences

How to achieve greater flexibility for tight cycling muscles (hamstring, lumbar paraspinals, etc.)

Time required: 60 - 90 minutes $195

Call (800) 548-4447 for any questions or to set up an appointment.

Our Pro Bike Fitting service is mobile and can come to your work or home.

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% body fat, lean body mass and recommendations for how to improve body composition to ideal values for your age group. $10

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2017 Solvang Century,

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2017 Solvang Century,

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Souvenirs

Souvenirs may be ordered online or by mail until February 22, 2017 for pickup at the event. In the event you are unable to attend, we will mail your souvenirs to the entry form address. Souvenirs will be available for purchase at the cycling festival in SCOR booth on a first come, first served basis. If we run out of any souvenirs, we will take orders and mail the items to you 2-3 weeks after the ride. You may also purchase souvenirs at our Online-Shop without registering for the ride.

Transfer Policy

If something changes in your schedule at the last minute and prevents your attendance, we will issue a voucher that may be redeemed and used to enter the 2018 Solvang Century, Metric & Half Century without financial consequence. You must notify us of your inability to attend by no later than 02/22/2017 to receive a voucher. Any souvenirs ordered from this year will be mailed to you in the week following the ride.

Registration Saver

SCOR has arranged to make available to our riders a new AIG Insurance policy called "Registration Saver." The policy covers your non-refundable registration fee, plus any travel expenses, if applicable. For an additional 6% of your registration fee and related travel costs, the policy reimburses you in the event unforeseen circumstances prevent you from riding, including sickness, injury, active military duty, job transfer, traffic accident, etc. To learn more about the coverage and apply for a policy, visit www. registrationsaver. com/?Code=u4if

Free Entry Offer!

PROBIKEFITS are available to anyone wishing to enter and will have their entry fee waived. Randy Ice PT, CCS has 30 years of fitting experience and will make you more comfortable on your bike as well as relieve any pain syndromes you may be suffering from. The cost of a PROBIKEFIT is $195. The service is mobile and can come to your home or work.

Call 1 800 548 4447 or (760) 468-4718 for more information or to schedule an appointment.

DEADLINE – FEBRUARY 22, 2017

MAPS & ROUTE INFO

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Safety

Helmets are mandatory. You do not have to show helmets at registration. SCOR will have helmets available for purchase in the SCOR merchandise booth. It is recommended each rider bring (2) water bottles, a tube, patch kit, tire levers, pump, a spare tire and warm clothing in layers that can be shed as the day warms up and carried with you. Bring rain gear if need be. Clothing drops will be available at the SAG stop #1 and SAG stop #2.

THIS IS NOT A RACE!

PLEASE BE COURTEOUS OF LOCAL DRIVERS AND TRAFFIC.

PLEASE OBEY ALL TRAFFIC LAWS! The CHP and Sheriff’s Dept. will be on course to direct traffic at key intersections. Be sure to come to a complete stop at all traffic signals and stop signs not controlled by law enforcement personnel.

RIDE SINGLE FILE PLEASE!!

Note: Riders who violate vehicle code laws, ride unsafely, are discourteous, rude or dangerous to other riders (or law enforcement personnel) will not be allowed to enter future SCOR events and will receive tickets for vehicle code violations.

Pacelines - If you ride in a paceline, please announce “on your left” when passing other riders. Please understand that you assume all liabilities and risks for riding in a paceline. Please pass riders with at least two feet of clearance between you and the rider you pass on the left.

No personal support vehicles please. Trikke bikes are prohibited.

Headphones, Walkmans and iPods are forbidden by law!

Register & SHOP

accommodations

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ASUNDHA (ASHWAGANDHA) INDICATIONS

Asundha works as an adaptogen, promoting the body's ability to maintain homeostasis and resist stress.

It is especially beneficial in stress related disorders such as arthritis, hypertension, diabetes, general debility, etc. It has also shown impressive results when used as stimulants for the immune system.

Asundha contains chemicals that might help calm the brain, reduce swelling (inflammation), lower blood pressure, and alter the immune system.

ASUNDHA (ASHWAGANDHA) INSTRUCTIONS

Talk with your health provider.

Asundha seems to be safe when taken by mouth, short-term. The long-term safety of ashwagandha is not known. Large doses of ashwagandha might cause stomach upset, diarrhea, and vomiting.

If you miss a dose of this medicine and you are using it regularly, take it as soon as possible. Do not take 2 doses at once.

ASUNDHA (ASHWAGANDHA) STORAGE

The appropriate dose of ashwagandha depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for ashwagandha. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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See Also

Timolol Ophthalmic Medlineplus Drug Information, Timerol

Timolol Ophthalmic

How should this medicine be used?

Ophthalmic timolol comes as a solution (liquid) and an extended-release (long-acting) gel-forming solution (liquid that thickens to a gel when instilled in the eye). Timolol eye drops are usuallyinstilled once or twice a day, at evenly spaced intervals, until pressure in the eye is controlled (about 4 weeks). Then it may be instilled once a day. Timolol gel-forming solution is usually instilled once a day. Follow the directions on your prescription label carefully, and ask doctor or pharmacist to explain any part you do not understand. Use timolol exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Timolol eye drops and gel-forming solution control glaucoma but do not cure it. Continue to use timolol even if you feel well. Do not stop using the medication without talking to your doctor.

To instill the eye drops or eye gel, follow these steps:

Wash your hands thoroughly with soap and water.

If you are using the gel-forming solution, invert the container and shake it once. (There is no need to shake the eye-drops.) Make sure that the end of the dropper is not chipped or cracked.

Avoid touching the dropper tip against your eye or anything else; eye drops and droppers must be kept clean.

While tilting your head back, pull down the lower lid of your eye with your index finger to form a pocket.

Hold the dropper (tip down) with the other hand, as close to the eye as possible without touching it.

Brace the remaining fingers of that hand against your face.

If you are using the eye drops, gently squeeze the dropper so that a single drop falls into the pocket made by the lower eyelid. If you are using the gel-forming solution, check the directions that came with your medication to see whether you should push the bottom of the bottle so that a single drop falls out or press a specially marked area on the side of the bottle. If you are using the type of bottle that must be pushed from the bottom, be careful not to squeeze the sides of the bottle. Remove your index finger from the lower eyelid.

Close your eye for 2 to 3 minutes and tip your head down as though looking at the floor. Try not to blink or squeeze your eyelids.

Place a finger on the tear duct and apply gentle pressure.

Wipe any excess liquid from your face with a tissue.

If you are to use more than one drop in the same eye, wait at least 5 minutes before instilling the next drop.

Replace and tighten the cap on the dropper bottle. Do not wipe or rinse the dropper tip.

Wash your hands to remove any medication.

Other uses for this medicine

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before using timolol eye drops or gel-forming solution,

tell your doctor and pharmacist if you are allergic to timolol, beta blockers, or any other drugs.

tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially beta blockers such as atenolol (Tenormin), carteolol (Cartrol), esmolol (Breviblic), labetalol (Normodyne, Trandate), metoprolol (Lopressor), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), and timolol (Blocadren); quinidine (Quinidex, Quinaglute Dura-Tabs); verapamil (Calan, Isoptin); and vitamins.

if you are using another topical eye medication, instill it at least 10 minutes before or after you instill timolol eye drops or gel-forming solution.

tell your doctor if you have or have ever had thyroid, heart, or lung disease; congestive heart failure; myasthenia gravis; or diabetes.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using timolol, call your doctor immediately.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are using timolol.

if you have eye surgery, an eye injury, or develop an eye infection while using timolol eye drops or gel-forming solution, ask your doctor if you can continue using the same container of timolol.

you should know that your vision may be blurred during your treatment with timolol gel-forming solution. Avoid rubbing your eyes even if your vision is blurred. Do not drive a car or operate machinery if you are unable to see clearly.

if you wear soft contact lenses, remove them before instilling timolol eye drops or gel-forming solution, and wait until 15 minutes after using timolol to put them back in.

What should I do if I forget a dose?

Instill the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not instill a double dose to make up for a missed one.

Cefuroxime - Brand Name List From, Enfexia

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Disclaimer: The indications, uses and warnings for individual medications outside the USA are determined by local regulatory bodies in each country or region. The Drugs. com website is intended primarily for audiences in the United States and its territories. Indications, uses and warnings on Drugs. com patient information leaflets are derived from FDA product labels and may differ in countries outside the USA. Every effort has been made to ensure that the information provided on this page is accurate, up-to-date and complete, but no guarantee is made to that effect. Drugs. com does not endorse drugs, diagnose patients or recommend specific therapies. The information on this page is not a substitute for the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that a drug or drug combination is safe, effective or appropriate for any given patient. Drugs. com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Always consult your doctor or healthcare specialist for medical advice.

Chemical formula: C16H16N4O8S Drugbank ID: DB01112 ATC code(s): J01DC02, J01RA03, S01AA27

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"We believe the pledge sends a powerful and important signal. We know we must do better, and we believe that by acting collectively we can do better. We also hope that it will send a very clear and strong signal to those young persons, who perhaps haven't even imagined a career in college sports, that there is a place for persons of color and women in college sports. And we hope that we will find ways of encouraging and creating the opportunities for professional growth and development that will bring better results so that, a decade down the road from now, we will have made great progress."

-- Jay Lemons, interim Board of Governors chair and president of Susquehanna University, on the approved diversity pledge.

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1 Why Is it Used ?

NIMODIPINE :

Adult: PO Prophylaxis of neurological deficit following subarachnoid haemorrhage 60 mg 4 hrly for 21 days beginning w/in 4 days of onset of haemorrhage. IV Ischaemic neurological deficits following subarachnoid haemorrhage Initial: 1 mg/hr for 2 hr, up to 2 mg/hr if no severe decrease in BP is observed. Start treatment at once and continue for 5-14 days. Total duration should not exceed 21 days if patient has received oral treatment.

2 What are the Side Effects ?

NIMODIPINE :

Peripheral oedema, hypotension, palpitations, tachycardia, flushing, dizziness, headache, nausea, increased micturition frequency, lethargy, eye pain, mental depression, visual disturbances, gingival hyperplasia, myalgia, tremor, impotence, fever, paradoxical increase in ischaemic chest pain during initiation of treatment, rashes, abnormalities in liver function (including cholestasis), GI obstruction in some tablets covered in indigestable membrane. Potentially Fatal: Angina/MI, symptomatic hypotension.

3 What Precautions should be taken ?

NIMODIPINE :

Cerebral oedema, severely raised intracranial pressure, idiopathic hypertrophic subaortic stenosis (IHSS), elderly, severe liver disease. Inadvertent IV admin of the contents of capsules has resulted in CV collapse, hypotension, bradycardia and death. Tablets should not be administered concomitantly with IV solution.

4 Do not take this if you have any of the below.

NIMODIPINE :

5 Interaction with other medicines.

NIMODIPINE :

Potentiates hypotensive effect of antihypertensives. Additive effects with sildenafil, tadalafil, vardenafil. Reduced effects with calcium. Decreased levels/effects with CYP3A4 inducers (e. g aminoglutethimide, carbamazepine, nafcillin, nevirapine, phenobarbital, phenytoin, and rifamycins). Increased levels/effects with cimetidine, sodium valproate, CYP3A4 inhibitors (e. g. azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone, nicardipine, propofol, protease inhibitors, quinidine, telithromycin, and verapamil).

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Buy Arthritis - Dolo-Spedifen (Brand Name Motrin) Online - Order Ibuprofen - Purchase Arthritis - Do

Motrin is used for treating rheumatoid arthritis, osteoarthritis, menstrual cramps, or mild to moderate pain. Motrin is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Motrin as directed by your doctor.

Take Motrin by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Motrin with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Motrin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Motrin .

Store Motrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Motrin out of the reach of children and away from pets.

Active Ingredient: Ibuprofen.

Do NOT use Motrin if:

you are allergic to any ingredient in Motrin

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Motrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, lupus, asthma, or growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse.

Some medicines may interact with Motrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Probenecid because it may increase the risk of Motrin 's side effects

Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Motrin

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Motrin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Motrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Motrin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Motrin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Motrin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Motrin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Motrin has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Motrin unless your doctor tells you to.

Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Use Motrin with caution in the elderly; they may be more sensitive to its effects, including stomach bleeding and kidney problems.

Motrin should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Motrin may cause harm to the fetus. Do not take it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Motrin while you are pregnant. It is not known if Motrin is found in breast milk. Do not breastfeed while taking Motrin .

All medicines can cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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