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Generic Name: Aciclovir Product Name: Acihexal Cream

Indication

Acyclovir is an antiviral agent which is active against types 1 and 2 of herpes simplex virus types 1 and 2 (that cause genital herpes) and varicella zoster virus (that causes shingles) Acyclovir is used for the followingTreatment of a first episode of genital herpes Management of recurrent episodes of genital herpes in certain patients. Treatment of shingles when the rash has been present for less than 72 hoursThe management of patients with advanced HIV disease

Action

Acyclovir is an antiviral agent which is active against types 1 and 2 of herpes simplex virus types 1 and 2 (causes genital herpes) and varicella zoster virus (causes shingles) Acyclovir prevents the virus from replicating in the cell and thus precents it from infecting more cells in the body

Dose advice

First episode of genital herpes:

200 mg every four hours while awake resulting in a total of 1000mg a day. This dose should be continued for ten days.

Suppressive therapy for recurrent genital herpes:

200 mg three times daily for six months.

After 6 months Acyclovir should be ceased

Intermittent therapy for recurrent genital herpes:

200 mg every four hours while awake resulting in a total of 1000mg a day.

This dose should be continued for five days.

Acyclovir should started as soon as signs or symptoms of a recurrent episode appear

800 mg five times daily at four hour intervals

Treatment should start as soon as possible after the rash appears

This dose should be continued for seven days.

For shingles with eye involvement therapy should be continued for seven to ten days

Advanced HIV disease:

800 mg four times daily at six hour intervals for 12 months.

Doses may required adjustment in patients with reduced kidney function

Schedule

Common side effects

Nausea and vomiting

Headache

Dizziness

Aching joints

Gastrointestinal disturbance

Uncommon side effects

Diarrhoea

Loss of appetite

Fatigue

Swelling of the ankles and lower legs

Skin rashes

Leg pain

Taste alteration

Sore throat

Heart palpitation

Muscle cramps

Irritability

Hair loss

Confusion

Hallucinations

Sleep disturbances

Convulsions

Chest pain

Constipation

For further information talk to your doctor.