Dectancyl Indication, Action Of Dectancyl, Interactions, Dectancyl


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Dectancyl [in more detail]

Dectancyl Indication:

Injection: for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.

Ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.

Ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus

Topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses

Oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy

Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps

Dectancyl Mechanism Of Action:

Dectancyl is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. This results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase A 2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Dectancyl Drug Interactions:

Ambenonium The corticosteroid decreases the effect of anticholinesterases Aminoglutethimide Aminogluthetimide decreases the effect of dexamethasone Amobarbital The barbiturate decreases the effect of the corticosteroid Anisindione The corticosteroid alters the anticoagulant effect Aprepitant Aprepitant increases the effect and toxicity of dexamethasone Aprobarbital The barbiturate decreases the effect of the corticosteroid Aspirin The corticosteroid decreases the effect of salicylates Butabarbital The barbiturate decreases the effect of the corticosteroid Butalbital The barbiturate decreases the effect of the corticosteroid Butethal The barbiturate decreases the effect of the corticosteroid Dicumarol The corticosteroid alters the anticoagulant effect Dihydroquinidine barbiturate The barbiturate decreases the effect of the corticosteroid Edrophonium The corticosteroid decreases the effect of anticholinesterases Ethotoin The enzyme inducer decreases the effect of the corticosteroid Fosphenytoin The enzyme inducer decreases the effect of the corticosteroid Heptabarbital The barbiturate decreases the effect of the corticosteroid Hexobarbital The barbiturate decreases the effect of the corticosteroid Imatinib Decreases levels of imatinib Mephenytoin The enzyme inducer decreases the effect of the corticosteroid Methohexital The barbiturate decreases the effect of the corticosteroid Methylphenobarbital The barbiturate decreases the effect of the corticosteroid Midodrine Increased arterial pressure Neostigmine The corticosteroid decreases the effect of anticholinesterases Pentobarbital The barbiturate decreases the effect of the corticosteroid Phenobarbital The barbiturate decreases the effect of the corticosteroid Phenytoin The enzyme inducer decreases the effect of the corticosteroid Primidone The barbiturate decreases the effect of the corticosteroid Pyridostigmine The corticosteroid decreases the effect of anticholinesterases Quinidine barbiturate The barbiturate decreases the effect of the corticosteroid Rifampin The enzyme inducer decreases the effect of the corticosteroid Secobarbital The barbiturate decreases the effect of the corticosteroid Sunitinib Possible decrease in sunitinib levels Talbutal The barbiturate decreases the effect of the corticosteroid Warfarin The corticosteroid alters the anticoagulant effect Bismuth The corticosteroid decreases the effect of salicylates Acenocoumarol The corticosteroid alters the anticoagulant effect Salicylate-magnesium The corticosteroid decreases the effect of salicylates Salsalate The corticosteroid decreases the effect of salicylates

Food Interactions:

Avoid alcohol. Take with food to reduce irritation. Avoid taking with grapefruit juice.

Dectancyl Chemical Formula: