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Dronactin

Dronactin - General Information

A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. [PubChem]

Pharmacology of Dronactin

Dronactin is a piperidine antihistamine. Unlike other antihistamines, this drug also antagonizes serotonin receptors. This action makes Dronactin useful in conditions such as vascular headache and anorexia. Dronactin does not prevent the release of histamine but rather competes with free histamine for binding at HA-receptor sites. Dronactin competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. Most antihistamines possess significant anticholinergic properties, but Dronactin exerts only weak anticholinergic actions. Blockade of central muscarinic receptors appears to account for Dronactin's antiemetic effects, although the exact mechanism is unknown. Dronactin also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite center of the hypothalamus may account for Dronactin's ability to stimulate appetite. Dronactin also has been used to counter vascular headaches. which many believe are caused by changes in serotonin activity, however it is unclear how Dronactin exerts a beneficial effect on this condition.

Dronactin for patients

Antihistamines may diminish mental alertness; conversely, particularly, in the young child, they may occasionally produce excitation. Patients should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery.

Dronactin Interactions

MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines. Antihistamines may have additive effects with alcohol and other CNS depressants, e. g. hypnotics, sedatives, tranquilizers, antianxiety agents.

Dronactin Contraindications

Newborn or Premature Infants

This drug should not be used in newborn or Premature infants.

Because of the higher risk of antihistamines for infants generally and for newborns and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.

Hypersensitivity to cyproheptadine and other drugs of similar chemical structure. Monoamine oxidase inhibitor therapy

Angle-closure glaucoma

Stenosing peptic ulcer

Symptomatic prostatic hypertrophy

Bladder neck obstruction

Pyloroduodenal obstruction

Elderly, debilitated patients

Additional information about Dronactin

Dronactin Indication: For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine. Mechanism Of Action: Dronactin competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Drug Interactions: Donepezil Possible antagonism of action Fluoxetine Possible antagonism of action Galantamine Possible antagonism of action Metyrapone This combination renders test invalid Rivastigmine Possible antagonism of action Food Interactions: Take with food. Avoid alcohol. Generic Name: Cyproheptadine Synonyms: Not Available Drug Category: Anti-Allergic Agents; Gastrointestinal Agents; Antipruritics; Antihistamine derivatives Drug Type: Small Molecule; Approved Other Brand Names containing Cyproheptadine: Cypoheptadine; Cyproheptadiene; Cyproheptadine Hcl; Dibenzosuberonone/Cyproheptadine; Dronactin; Eiproheptadine; Periactin; Periactine; Periactinol; Peritol; Absorption: Well absorbed after oral administration. Toxicity (Overdose): Not Available Protein Binding: 96 to 99% Biotransformation: Hepatic (cytochrome P-450 system) and some renal. Half Life: Not Available Dosage Forms of Dronactin: Tablet Oral Syrup Oral Chemical IUPAC Name: Not Available Chemical Formula: C21H21N Cyproheptadine on Wikipedia: http://en. wikipedia. org/wiki/Cyproheptadine Organisms Affected: Humans and other mammals