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Buspirone Side Effects

For the Consumer

Applies to buspirone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by buspirone. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking buspirone:


Chest pain


fast or pounding heartbeat



mental depression

muscle weakness

numbness, tingling, pain, or weakness in the hands or feet

skin rash or hives

sore throat

stiffness of the arms or legs

uncontrolled movements of the body

If any of the following symptoms of overdose occur while taking buspirone, get emergency help immediately:

Symptoms of overdose:

Dizziness or lightheadedness especially when getting up from a sitting or lying position suddenly

drowsiness (severe)

loss of consciousness

nausea or vomiting

stomach upset

very small pupils of the eyes

Minor Side Effects

Some of the side effects that can occur with buspirone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

Restlessness, nervousness, or unusual excitement

Less common or rare:

Blurred vision

clamminess or sweating

decreased concentration



dryness of the mouth

muscle pain, spasms, cramps, or stiffness

ringing in the ears

trouble with sleeping, nightmares, or vivid dreams

unusual tiredness or weakness

For Healthcare Professionals

Applies to buspirone: compounding powder, oral tablet

Nervous system

Very common (10% or more): Dizziness (12%), drowsiness (10%) Common (1% to 10%): Lightheadedness, decreased concentration, numbness, paresthesia, incoordination, headache, tremor, syncope, seizures Rare (less than 0.1%): Cerebrovascular accident Very rare (less than 0.01%): Serotonin syndrome, amnesia, cogwheel rigidity, dystonia/dystonic reactions, dyskinesias (acute and tardive), ataxias, parkinsonism, akathisia, restless leg syndrome Postmarketing reports: Vertigo, extrapyramidal symptoms, transient difficulty with recall [Ref ]


Common (1% to 10%): Tachycardia/palpitations, chest pain Uncommon (0.1% to 1%): Hypotension, hypertension Rare (less than 0.1%): Congestive heart failure, myocardial infarction, cardiomyopathy, bradycardia [Ref ]


Common (1% to 10%): Rash, sweating/clamminess Uncommon (0.1% to 1%): Pruritus, flushing, easy bruising, hair loss, dry skin, facial edema, blisters Rare (less than 0.1%): Acne, thinning of nails, ecchymosis, urticaria [Ref ]


Common (1% to 10%): Nausea, dry mouth, abdominal/gastric distress, diarrhea, constipation, vomiting Uncommon (0.1% to 1%): Flatulence, anorexia, increased appetite, salivation, irritable colon, rectal bleeding Rare (less than 0.1%): Burning of the tongue [Ref ]


Common (1% to 10%): Musculoskeletal aches/pains Uncommon (0.1% to 1%): Muscle cramps, muscle spasms, rigid/stiff muscles, arthralgias Rare (less than 0.1%): Muscle weakness [Ref ]


Common (1% to 10%): Blurred vision Uncommon (0.1% to 1%): Eye redness and itching, conjunctivitis, eye pain, eye pressure, photophobia Very rare (less than 0.01%): Visual changes (including tunnel vision) [Ref ]


Common (1% to 10%): Fatigue, weakness, tinnitus, sore throat Uncommon (0.1% to 1%): Altered taste, altered smell, inner ear abnormality, edema, fever, roaring sensation in the head, malaise Rare (less than 0.1%): Alcohol abuse, loss of voice, hiccoughs [Ref ]


Common (1% to 10%): Insomnia, nervousness, excitement, anger/hostility, confusion, depression, dream disturbances, attention disturbance, sleep disorder Uncommon (0.1% to 1%): Depersonalization, dysphoria, noise intolerance, euphoria, akathisia, fearfulness, loss of interest, dissociative reaction, hallucinations, involuntary movements, slowed reaction time, suicidal ideation, decreased or increased libido Rare (less than 0.1%): Claustrophobia, cold intolerance, stupor, slurred speech, psychosis, delayed ejaculation, impotence Very rare (less than 0.01%): Depersonalization Postmarketing reports: Emotional lability, restlessness [Ref ]


Common (1% to 10%): Nasal congestion, pharyngolaryngeal pain Uncommon (0.1% to 1%): Hyperventilation, shortness of breath, chest congestion Rare (less than 0.1%): Epistaxis [Ref ]


Uncommon (0.1% to 1%): Urinary frequency, urinary hesitancy, menstrual irregularity and spotting, dysuria Rare (less than 0.1%): Amenorrhea, pelvic inflammatory disease, enuresis, nocturia Very rare (less than 0.01%): Urinary retention [Ref ]


Uncommon (0.1% to 1%): Increases in hepatic aminotransferases (SGOT, SGPT) [Ref ]


Uncommon (0.1% to 1%): Weight gain, weight loss [Ref ]


Rare (less than 0.1%): Galactorrhea, thyroid abnormality [Ref ]


Rare (less than 0.1%): Eisonophilia, leukopenia, thrombocytopenia, bleeding disturbance [Ref ]


Postmarketing reports: Allergic reactions, angioedema [Ref ]


1. "Product Information. Buspar (buspirone)." Bristol-Myers Squibb, Princeton, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for buspirone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .

More about buspirone

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