Apo-Ciproflox - Uses, Side Effects, Interactions, Cipflox

Apo-Ciproflox

How does this medication work? What will it do for me?

Ciprofloxacin is an antibiotic that belongs to the family of medications known as quinolones. It is used to treat infections caused by certain bacteria. It is most commonly used to treat infections of the skin, sinuses, bone, lung, abdomen, kidney, prostate, and bladder.

It can also be used to treat some sexually transmitted infections (STIs), some forms of infectious diarrhea, and typhoid fever.

The extended release form of ciprofloxacin is used to treat bladder and kidney infections.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

250 mg Each round, white, film-coated, biconvex tablet, identified "APO" on one side and "CIP" over "250" on the other, contains ciprofloxacin HCl monohydrate equivalent to ciprofloxacin 250 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, and titanium dioxide.

500 mg Each capsule-shaped, white, film-coated, biconvex tablet, engraved "APO-500" on one side, contains ciprofloxacin HCl monohydrate equivalent to ciprofloxacin 500 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, and titanium dioxide.

750 mg Each capsule-shaped, white, film-coated, biconvex tablet, engraved "APO-750" on one side, contains ciprofloxacin HCl monohydrate equivalent to ciprofloxacin 750 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, and titanium dioxide.

How should I use this medication?

The recommended adult dose of ciprofloxacin tablets ranges from 250 mg to 750 mg twice daily. Depending on the type of infection being treated, you may need to take ciprofloxacin for 3 to 14 days. For bone infections it may be necessary to take ciprofloxacin for as long as 3 months. For STIs, the dose is given once as a single dose.

Ciprofloxacin tablets may be taken with food or on an empty stomach. Drink plenty of fluids while taking ciprofloxacin and avoid dairy products. Although ciprofloxacin can be taken with meals that include milk, you should not take ciprofloxacin with dairy products alone or with calcium-fortified products. Do not take antacids; supplements with calcium, magnesium, aluminum, or iron; or multivitamins 6 hours before or 2 hours after taking ciprofloxacin.

If you are taking the suspension form of this medication, use a medication syringe to measure each dose as it gives a more accurate measurement than household teaspoons. Shake the bottle well before measuring.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by your doctor. Even if you start to feel better after the start of treatment, it's important to finish the entire amount that was prescribed. This helps to prevent the infection from returning and being harder to treat. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not administer a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store the tablets at room temperature and keep them out of the reach of children. Store the oral suspension at room temperature or in the refrigerator in an upright position, protect it from freezing, and keep it out of the reach of children. After 14 days, safely discard any remaining medication.

Do not dispose of medications in wastewater (e. g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not use ciprofloxacin if you:

are allergic to ciprofloxacin or any ingredients of the medication

are allergic to other quinolone antibiotics

are taking tizanidine

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who uses this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people using this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

dizziness

general feeling of being unwell

increased skin sensitivity to the sun

loss of appetite

mild diarrhea

nausea

pain at the injection site (injection form)

rash (injection form)

ringing in the ears

stomach discomfort or gas

sweating

trouble sleeping

vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

coordination problems (unsteady walk)

fainting

hallucinations (hearing or seeing things that aren’t there)

irregular or fast heart rate

joint pain

migraine

muscle pain

numbness or burning, tingling pain

pain, inflammation, or swelling in the shoulders, hands, or calves of legs

pain, swelling, or rupture of a tendon

severe abdominal or stomach cramps or pain

signs of depression (e. g. poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)

signs of liver problems (e. g. nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)

symptoms of high blood sugar (e. g. frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)

symptoms of low blood sugar (e. g. cold sweat, cool pale skin, headache, fast heartbeat, weakness)

vision changes

Stop using the medication and seek immediate medical attention if any of the following occur:

confusion or changes in thought patterns

diarrhea (watery and severe; may also be bloody)

seizures

signs of a serious allergic reaction (e. g. abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

signs of a severe skin reaction (e. g. blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergic reactions: In rare cases, some people may develop an allergic reaction to this medication. Signs of an allergic reaction include a severe rash, swollen face, or difficulty breathing. If these occur, get immediate medical attention.

Antibiotic-related diarrhea: This medication, like other antibiotics, can cause a potentially dangerous, severe form of diarrhea called antibiotic-associated colitis or pseudomembranous colitis . Symptoms include severe, watery diarrhea that may be bloody. If you notice these symptoms, stop taking ciprofloxacin and contact your doctor as soon as possible.

Behaviour and movement changes: Rarely, this medication can cause behaviour and movement changes such as agitation, anxiety, confusion, depression, tremors, hallucinations, and other mood changes. If you experience any of the above, contact your doctor immediately.

Driving and operating heavy machinery: Ciprofloxacin may impair your ability to drive or operate machinery, especially when combined with alcohol. Do not drive or operate machinery until you know how this medication affects you.

Kidney function: Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects, since ciprofloxacin is removed from the body primarily by the kidneys. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: Ciprofloxacin may reduce liver function and can cause liver failure. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Neuromuscular disorders: Ciprofloxacin may cause increased muscle weakness for people with myasthenia gravis (an autoimmune disorder that causes muscle weakness). If you have myasthenia gravis, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Other infections: Use of ciprofloxacin for a long time may lead to yeast infections.

QT prolongation: This medication can lengthen heartbeat as shown on an electrocardiogram test, also known as QT prolongation . Very rare cases of abnormal heartbeat have been reported in people while on ciprofloxacin, but these reports generally involved people who had conditions that predisposed them to abnormal heartbeat, or who have been taking other medications that can increase the risk of developing an abnormal heartbeat. If you have heart disease and abnormal heart rhythms, or are taking certain medications (e. g. verapamil, atazanavir), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you develop heart palpitations (fast or irregular heartbeat) or experience fainting spells, stop taking ciprofloxacin and contact your doctor immediately.

Seizures: Rarely, seizures have been reported with this medication. If you have a history of epilepsy or medical conditions that increase the risk of seizures, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you have a seizure while taking this medication, stop taking it and get immediate medical attention.

Sucrose intolerance: The oral suspension form of this medication contains sucrose. People who have a hereditary condition that makes them intolerant to some sugars should not take the oral suspension.

Sun sensitivity: People who take ciprofloxacin are more likely to experience sunburn. Avoid exposure to excessive sunlight, including sunlamps and tanning beds. If you must spend time in the sun use sunblock with minimum SPF 15. Talk to your doctor if severe sun sensitivity occurs.

Tendinitis: Ciprofloxacin may increase the chance of tendon injury, which occurs more commonly for seniors who are also taking corticosteroid medications. If there is any new pain in the tendons, stop taking ciprofloxacin, avoid physical exercise, and consult your doctor.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, stop taking it immediately and call your doctor.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking ciprofloxacin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of this medication have not been established for children less than 18 years of age.

What other drugs could interact with this medication?

There may be an interaction between ciprofloxacin and any of the following:

abiraterone

acetylsalicylic acid (ASA)

alfuzosin

amantadine

amiodarone

anagrelide

antacids that contain aluminum hydroxide, calcium, and magnesium hydroxide (do not take these products for at least 6 hours before or for 2 hours after ciprofloxacin)

antihistamines (e. g. cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)

antipsychotics (e. g. chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)

apomorphine

atorvastatin

"azole" antifungals (e. g. itraconazole, ketoconazole, voriconazole)

BCG vaccine

bendamustine

bosutinib

buffered antiretroviral medications (e. g. didanosine; do not take these products for at least 6 hours before or for 2 hours after ciprofloxacin)

caffeine

calcium supplements and multivitamins that contain calcium (do not take these products for at least 6 hours before or for 2 hours after ciprofloxacin)

certain medications that control heart rhythm

carbamazepine

carvedilol

chloral hydrate

chloroquine

cisapride

inhaled corticosteroids (e. g. budesonide, ciclesonide, fluticasone)

oral corticosteroids (e. g. dexamethasone, hydrocortisone, prednisone)

cyclosporine

dacarbazine

darunavir

dasatinib

dexamethasone

dipyridamole

disopyramide

domperidone

doxorubicin

dronedarone

duloxetine

estrogens (estradiol, conjugated equine, esterified, estropipate)

famotidine

flecainide

flutamide

formoterol

galantamine

grapefruit juice

HIV protease inhibitors (e. g. atazanavir, indinavir, ritonavir, saquinavir)

indapamide

insulin

iron supplements (e. g. ferrous fumarate, ferrous gluconate, ferrous sulfate: do not take these products for at least 6 hours before or for 2 hours after ciprofloxacin)

lidocaine

lithium

macrolide antibiotics (e. g. clarithromycin, erythromycin)

magnesium supplements (e. g. magnesium hydroxide, magnesium oxide)

maprotiline

mefloquine

melatonin

methadone

methotrexate

mexiletine

mifepristone

mirtazapine

multiple vitamins and minerals with vitamins A and E

multivitamins that contain iron (do not take these products for at least 6 hours before or for 2 hours after ciprofloxacin)

mycophenolate

nefazodone

nelfinavir

nonsteroidal anti-inflammatory drugs (NSAIDs; e. g. ibuprofen, naproxen)

omeprazole

octreotide

oxycodone

paliperidone

pentamidine

pentoxifylline

phenytoin

pimozide

probenecid

procainamide

progesterone

propafenone

propranolol

prazosin

rasagiline

romidepsin

ropinirole

roflumilast

quinapril

quinidine

quinine

other quinolone antibiotics (e. g. norfloxacin, ofloxacin)

rifampin

ropinirole

St. John’s wort

selective serotonin reuptake inhibitors (SSRIs; e. g. citalopram, duloxetine, fluoxetine, paroxetine, sertraline)

serotonin antagonists (anti-emetic medications; e. g. granisetron, ondansetron)

sevelamer

sodium picosulfate

sotalol

sildenafil

sucralfate (do not take these products for at least 6 hours before or for 2 hours after ciprofloxacin)

sulfamethoxazole

sulfonylureas (e. g. gliclazide, glyburide)

sunitinib

tacrolimus

tamoxifen

telaprevir

tetrabenazine

theophyllines (e. g. aminophylline, oxtryphylline, theophylline)

tizanidine

trazodone

trimethoprim

tricyclic antidepressants (e. g. amitriptyline, clomipramine, desipramine, trimipramine)

typhoid vaccine

tyrosine kinase inhibitors (e. g. dasatinib, imatinib, nilotinib, sunatinib)

vardenafil

varenicline

venlafaxine

verapamil

vinblastine

warfarin

zinc

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,

change one of the medications to another,

change how you are taking one or both of the medications, or

leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Obat Mata Bralifex Plus - Herbal Pesohor - Terbukti Ampuh, Bralifex Plus

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Apakah anda memiliki kesulitan melihat sesuatu yang lebih besar dari dekat atau mengalami mata plus ?

Perlu anda ketahui penyebab mata plus, atau biasa disebut dengan rabun dekat atau istilah kedokteran nya adalah Hipermetropia. Orang-orang yang menderita rabun dekat tidak dapat melihat atau membaca dalam jarak yang dekat, karena itu membutuhkan kaca mata plus atau kaca mata cembung. Hipermetropia merupakan gangguan penglihatan yang disebabkan menurunnya kemampuan otot serta syaraf mata.

Penyebab mata plus adalah karena bola mata yang lebih pendek dibandingkan dengan mata normal. Biasanya keadaan ini terjadi karena faktor usia. Hal tersebut merupakan salah satu proses penuaan pada orang-orang yang berusia di atas 40 tahun. Kondisi demikian biasanya tidak dapat disembuhakn, tetapi bisa di perbaiki dengan menggunakan kaca mata atau pun “contact lenses”. Tetapi beberapa penelitian mengungkapkan bahwa kondisi mata rabun jauh bisa disembukan dengan sering-sering meneteskan obat tetes mata, yang ternyata berguna untuk meremajakan otot mata yang sudah tidak lentur lagi.

Berikut beberapa keluhan yang perlu Anda waspadai mengenai kemungkinan Anda menderita rabun dekat :

Sakit kepala jika melihat atau membaca dalam jarak dekat dalam beberapa menit

Ketidak nyamanan pada saat melihat dalam jangka waktu tertentu, terutama ketika mata terfokus melihat sesuatu dalam jangka waktu yang cukup lama, misalnya menonton televisi.

Penglihatan kabur ketika melihat atau membaca dalam jarang dekat, walaupun usia Anda masih di bawah 40 tahun.

Mata cepat merasa lelah apabila melihat atau membaca dalam jarak yang dekat.

Jika Anda mulai merasa tidak nyaman dengan penglihatan Anda, segeralah melakukan tes penglihatan, agar Anda mendapatkan diagnosa yang tepat, jadi tidak perlu hanya mengira-ngira. Pemeriksaan mata secara teratur setiap tahun nya sangat dianjurkan untuk para penderita kelainan penglihatan. Hal ini disarankan agar penderita dapat mengetahui perkembangan terbaru dari keadaan penglihatn nya. Atau anda melakukan pengobatan alami dengan menggunakan eye care softgel denagn perlahan mata plus yang anda derita akan segera cepat teratasi secara alami tanpa menimbulkan efek samping .

Cara mengatasi mata plus secara tradisional dengan eye care sopftgel

Eye care Softgel merupakan solusi cara mengatasi mata plus secara tradisional dan produk unggulan dari Green World yang sudah terbukti dalam menyembuhkan Keluhan Mata Seperti Mata Minus. Mata Plus. Mata silinder. Mata berair dan Jenis keluhan mata lainnya. Produk Ini Memiliki kualitas tinggi yang sudah di pasarkan di berbagai negara .

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Zat ini mampu membangun kapiler kuat yang terdapat di sebagian besar pembuluh darah di mata sehingga meningkatkan aliran darah dan pengiriman oksigen ke dalam kapiler. Peningkatan aliran darah ke mata dapat mencegah hipertensi okular yang dapat mengurangi resiko glaukoma.

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Eyebright 25%

Ekstrak ginkgo biloba 15%

Lutein 5%

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Vitamin B2 Riboflavin sangat penting untuk kesehatan mata dan telah membantu dalam mengobati kelelahan mata dan katarak.

Taurine 3%

Ekstrak biji anggur 10%

VA 1%

Zinc 3%.

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Sudah kita ketahui bahwa kandungan yang terdapat dalam bluberry berbagai zat gizi, contohnya beberapa mineral (mangan, kalsium, fosfor, besi, kalium, dan seng), vitamin B1, B2, B3, dan B6, vitamin C, vitamin E, vitamin K, serta karbohidrat dan lemak. Kandungan mangan dan vitamin K buah Blueberry cukup tinggi, unsur kimia mangan adalah zat anti peradangan. Fungsinya secara tidak langsung melancarkan aliran darah dan meningkatkan daya ingat.

Manfaat Buah Blueberry untuk Menjaga Penglihatan dan kesehatan mata

Blueberry merupakan obat yang tepat untuk mencegah dan mengobati infeksi dan penyakit yang berkaitan dengan fungsi retina dan membantu mengontrol penglihatan agar selalu tajam. Masalah ocular juga dapat ditangani dengan mengkonsumsi blueberry secara regular.

Cara Pemakaian obat penyakit mata Eye Care Softgel :

Dewasa sehari sekali sebanyak 1-2 butir setiap kalinya. Anak-anak sehari sekali sebanyak 1 butir setiap kalinya. Diminum dengan segelas air. penyebab penyakit mata plus

Khasiat obat penyakit mata Eye Care Capsule. Eye Care Softgel

Produk ini dapat memenuhi nutrisi yang dibutuhkan mata, memperbaiki sirkulasi di bagian mata, menjaga kesehatan kapiler, mengurangi lelah, sakit dan kering pada mata. Melindungi lensa mata, mencegah penurunan daya penglihatan, mencegah glaukoma pada orang tua, katarak dan presbyopia. Mencegah mata kering, mata merah, mata gatal, rabun jauh dll yang disebabkan oleh penggunaan mata yang terlalu lama maupun radiasi dari komputer atau TV.

Kelompok Pemakai. Eye Care Softgel

Cocok untuk anak muda, dewasa, orang tua, anak sekolah, pekerja IT, pekerja yang banyak menggunakan komputer, supir, orang yang bekerja di tempat yang pencahayaannya kuat, orang yang ingin mencegah kebutaan, glaukoma, katarak, pendarahan retina, orang yang ingin memperbaiki daya penglihatan, pseudomyopia, penglihatan lemah, gejala pada retina sebagai komplikasi diabetes, retinitis pigmentosa, rabun senja dll.

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Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis. Diclofenac may also be used for purposes other than those listed in this medication guide.

Use Diclofenac as directed by your doctor.

Take Diclofenac by mouth with or without food. Ask your health care provider any questions you may have about how to use Diclofenac.

Drug Class and Mechanism

Diclofenac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

If you miss a dose of Diclofenac, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Store Diclofenac at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do not use Diclofenac if:

you are allergic to any ingredient in Diclofenac; you have had a severe allergic reaction (e. g. severe rash, hives, breathing difficulties, dizziness) to another NSAID (e. g. ibuprofen, naproxen, celecoxib) or aspirin. Contact your doctor or health care provider right away if any of these apply to you.

Important : Diclofenac may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Before you start any new medicine, check the label to see if it has Coyenpin or another nonsteroidal anti-inflammatory drug (NSAID) medicine in it too. If it does or if you are not sure, check with your doctor or pharmacist. Diclofenac should not be used in children; safety and effectiveness in children have not been confirmed. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breast-feed while using Diclofenac.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

burning or stinging; discharge; eye redness, irritation, or itching. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred or distorted vision; eye infection; eyelid swelling or redness; sensitivity to glare or light.

Diclofenac is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

Coryzal - Definition And Synonims Of Coryzal In English Dictionary, Coryzal

coryzal

DEFINITION OF CORYZAL

Common cold

The common cold is a viral infectious disease of the upper respiratory tract which primarily affects the nose. Symptoms include coughing, sore throat, runny nose, sneezing, and fever which usually resolve in seven to ten days, with some symptoms lasting up to three weeks. Well over 200 virus strains are implicated in the cause of the common cold; the rhinoviruses are the most common. Upper respiratory tract infections are loosely divided by the areas they affect, with the common cold primarily affecting the nose, the throat, and the sinuses, occasionally involving either or both eyes via conjunctivitis. Symptoms are mostly due to the body's immune response to the infection rather than to tissue destruction by the viruses themselves. The primary method of prevention is by hand washing with some evidence to support the effectiveness of wearing face masks. The common cold may occasionally lead to pneumonia, either viral pneumonia or secondary bacterial pneumonia. No cure for the common cold exists, but the symptoms can be treated.

Discover the use of coryzal in the following bibliographical selection. Books relating to coryzal and brief extracts from same to provide context of its use in literature.

Manson's Tropical Diseases

second to fifth weeks. Management is mainly supportive, although erythromycin 50 mg/kg per day for 10-14 days if given during the catarrhal stage may shorten the clinical course. This is of most use in contacts that develop a coryzal illness.

Gordon C. Cook, Alimuddin I. Zumla, 2009

MRCPCH 1: Questions with Individual Subject Summaries

Viral croup is typically associated with a prodrome of 24-48 hours of coryzal symptoms followed by the sudden onset of barking cough, horse voice, stridor and variable amounts of respiratory distress. It is commonly caused by parainfluenza.

R. M. Beattie, Joanne Borbone, Sarah A. L. Williams, 2011

A Guide to the Work-relatedness of Disease

At the latter exposure, all workers complained of respiratory symptoms including coryzal symptoms, continuous coughing, sore throat, dyspnea, fatigue, and night sweats. Subsequently, air concentration of TDI were reduced to 0.01 -0.03 ppm.

Mastering Public Health: A Postgraduate Guide to.

There may well not be a clear history of a crescendo of otalgia in a coryzal child, followed by rapid symptomatic relief associated with tympanic membrane perforation and associated blood-stained otorrhoea. The difficulty in establishing clear.

Geraint Lewis, Jessica Sheringham, Jamie Lopez Bernal, 2014

Acute coryzal illness, traditionally referred to as a 'common cold), manifests as nasal discharge and obstruction, sneezing and sore throat, and is most commonly caused by viruses, including rhinovi — rus, parainlluenza virus, influenza virus.

Phyllis Kozarsky, David O. Freedman, Hans D. Nothdurft, 2013

ERS Handbook of Paediatric Respiratory Medicine:

Clinicalfeatures: Children present with a coryzal . feverish illness which mimics a selflimiting URTI. At this stage the coryzal infant is highly infectious to non - immune close contacts. The classic, paroxysmal cough follows this stage and lasts for.

Ernst Eber, Fabio Midulla, 2013

A coryzal phase is followed by paroxysms of coughing which can last for several weeks. Post-tussive vomiting and inspiratory whoop are specific features. Complications are most common in infants and include weight-loss, hypoxia, apnoea.

Acute Respiratory Infections

5 CHAPTER 1 Acute respiratory infections Table 1.3 Typical features of common LRTls Acute bronchitis ' Cough, fever, malaise, coryzal symptoms ' RSV, rhinovirus, influenza, Streptococcus pneumoniae, Haemophilus influenzae (a viral.

Chalcogens: Advances in Research and Application: 2011 Edition

Three groups were studied: (1) normal controls, (2) subjects with coryzal symptoms and (3) adult patients with chronic lung disease who were admitted to hospital with an infective exacerbation. Each group received oxygen therapy, NIV using.

The cyclopaedia of practical medicine: comprising treatises.

Pus is sometimes secreted by the nasal fossae, but not in consequence of the coryzal form of inflammation, which terminates by the secretion becoming viscid, and then opaque, and then of a dirty greenish or yellowish colour, after which it.

Sir John Forbes, Alexander Tweedie, John Conolly, 1833

Sanofi U, Sanofi-Aventis

U. S. Career Center

At Sanofi US, we are committed to the growth of our people, connected in purpose by career, life and health.

Headquartered in Bridgewater, NJ, Sanofi US is part of a leading global healthcare company dedicated to discovering, developing and distributing therapeutic solutions focused on patients’ needs.

Sanofi has core strengths in diabetes solutions, human vaccines, innovative drugs, consumer healthcare, emerging markets, animal health and Genzyme.

Sanofi US employs approximately 17,000 people across the country all dedicated to protecting health, enhancing life and responding to the hopes and potential healthcare needs of seven billion people around the world.

Commitment is our Strength. Ready to grow together ?

Sanofi US endeavors to make our career center accessible to any and all users. If you are experiencing difficulty and need assistance applying online, please call 1-800-207-8049 Option 7, then Option 3 or click here .

Sanofi US has partnered with BountyJobs for our direct placement business. If interested in learning more, please go to www. BountyJobs. com and register with our referral code: Sanofi. You will then be contacted by a BountyJobs representative.

Sanofi US Services, Inc. and its U. S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

U. S. Career Center

At Sanofi US, we are committed to the growth of our people, connected in purpose by career, life and health.

Headquartered in Bridgewater, NJ, Sanofi US is part of a leading global healthcare company dedicated to discovering, developing and distributing therapeutic solutions focused on patients’ needs.

Sanofi has core strengths in diabetes solutions, human vaccines, innovative drugs, consumer healthcare, emerging markets, animal health and Genzyme.

Sanofi US employs approximately 17,000 people across the country all dedicated to protecting health, enhancing life and responding to the hopes and potential healthcare needs of seven billion people around the world.

Commitment is our Strength. Ready to grow together ?

Sanofi US endeavors to make our career center accessible to any and all users. If you are experiencing difficulty and need assistance applying online, please call 1-800-207-8049 Option 7, then Option 3 or click here .

Sanofi US has partnered with BountyJobs for our direct placement business. If interested in learning more, please go to www. BountyJobs. com and register with our referral code: Sanofi. You will then be contacted by a BountyJobs representative.

Sanofi US Services, Inc. and its U. S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

What Are Gravitons The Nature Of Reality - The Nature Of Reality, Granitron

What Are Gravitons?

By Don Lincoln on Wed, 14 May 2014

In a contest for the least contentious statement a person can make, “What goes up must come down” is surely a strong contender. Of the four known fundamental forces—gravity, the electromagnetic force, and the strong and weak nuclear forces—we have the most intuitive understanding of gravity. From our first experiments dropping Cheerios from our high chair, we spend our lives coming to grips with the limitations that gravity imposes on us.

In the late 1600s, Isaac Newton devised the first serious theory of gravity. He described gravity as a field that could reach out across great distances and dictate the path of massive objects like the Earth. Newton’s theory was stunningly effective, yet the nature of the gravitational field remained a mystery. In 1915, Albert Einstein’s theory of general relativity gave theorists their first look “under the hood” of gravity. What we call gravity, Einstein argued, is actually the distortion of space and time. The Earth looks like it’s rounding the Sun in an ellipse, but it’s actually following a straight line through warped spacetime.

Einstein’s theory of gravity is very good at explaining the behavior of large objects. But just a few years later, physicists opened up the world of the ultra-small, revealing that the other fundamental forces are due to the exchange of specialized force-carrying particles: photons convey electromagnetism, the strong nuclear force is transmitted by gluons and the weak nuclear force is imparted by the movement of the W and Z bosons. Is gravity due to the same kind of particle exchange?

We actually don’t know the answer to that question, but we have a name for that hypothetical particle if it does exist: It is called the graviton. And even though we have never observed a graviton, we know a great deal about them, if they are real. First, since the range of the force due to gravity is infinite and the force due to gravity weakens as one over the square of the distance between two objects (i. e. 1/r 2 ), the graviton must have zero mass. We know this because if the photon had mass, it would change the “2” in the exponent and that “2” has been established with incredible precision. Like massless photons, gravitons should travel at the speed of light.

General relativity also gives us some insight into the nature of gravitons. In general relativity, the distribution of mass and energy in the universe is described by a four-by-four matrix that mathematicians call a tensor of rank two. This is important because if the tensor is the source of gravitation, you can show that the graviton must be a particle with a quantum mechanical spin of two. Another nice fallout of this correspondence is that the graviton is the only possible massless, spin two particle. If you observe a massless, spin two particle, you have found the graviton.

So why hasn’t anyone found a graviton yet? The problem with searching for gravitons is that gravity is incredibly weak. For instance, the electromagnetic force between an electron and a proton in a hydrogen atom is 10 39 times larger than the gravitational force between the same two particles. Perhaps a more intuitive example is the behavior of a magnet and a paperclip. A magnet will hold a paperclip against the Earth’s gravity. Think about what that means. A little magnet, like the one that held your art to your parent’s refrigerator when you were a kid, pulls the paperclip upwards, while the gravity of an entire planet pulls downward, and the magnet wins .

Individual gravitons interact very feebly, and we are only held to the planet because the Earth emits so many of them. Because a single graviton is so weak, it is impossible for us to directly detect individual classical gravitons.

However, there are new and innovative ideas about gravity in which other forms of gravitons might exist. Some of these exotic gravitons might be detectable, but they require significant modifications to our understanding of our universe. This is where things get a bit mind-bending.

If “what goes up, must come down” might be a catch phrase for Captain Obvious, “we live in three dimensions” could be the rallying cry of his sidekick, Lieutenant Duh. However, some scientists have proposed the idea that gravity might have access to more than three dimensions. In that case, gravity might not actually be as weak as we think it is. It only appears weak because, unlike the other fundamental forces, it has extra dimensions into which it can “spread out.”

On the face of it, this seems silly. The 1/r 2 nature of gravity is an incontrovertible sign that gravity operates in three dimensions, and this behavior has been directly verified down to distances smaller than a millimeter. But this leaves open the possibility of extra dimensions smaller than 150 micrometers or so. One can imagine these small dimensions by thinking of a tightrope. To a tightrope walker, who can only walk forward and backward on the rope, the rope is one-dimensional. But to an ant, which can also crawl around the rope’s circumference, the rope seems to be two-dimensional. What appears to be one-dimensional to a large being is two-dimensional to a smaller one. These smaller dimensions are cyclical in that if you travel around the outside of one, you will end up back in the same place.

Quantum mechanics tells us that every particle is also a vibrating wave, and it has been proposed that gravitons could vibrate in these extra dimensions, wrapping around the small dimension like bracelets encircling a slender wrist. However, the cyclical nature of the extra dimension imposes limits on how a graviton can vibrate. Only an integer number of wavelengths can fit evenly in the extra dimension. And this brings us to a couple of interesting consequences. In theories with extra dimensions, more than one type of graviton can exist. One way to see that is to imagine taking a sine wave and wrapping it around a cylinder. In order for it to fit perfectly, you must use one wavelength or two or three or any integer number of wavelengths. Each of these instances is a distinct graviton; the ones with more vibrations can actually have mass. Particles of this kind are called Kaluza-Klein gravitons after physicists Theodor Kaluza and Oskar Klein, who first proposed the idea of additional small spatial dimensions. On tiny scales, Kaluza-Klein gravitons can have mass, but on larger scales, they reduce to the familiar massless gravitons of classical theory.

Using particle accelerators like the Large Hadron Collider, physicists are already searching for these small extra dimensions, in part by looking for the expected decay products of massive gravitons. They haven’t found anything yet, which means that if extra dimensions exist, they must be a thousand times smaller than a proton, although there are many caveats to how one interprets the data.

Gravity is the one known fundamental force that has resisted study in the quantum realm and finding gravitons of any kind would be a huge step forward in our understanding of the phenomenon. Devising a successful theory of quantum gravity is one of the hottest goals of modern physics and ongoing experimental searches for gravitons will play a central role.

Go Deeper Our picks for further reading

Nature of Reality: What Is Gravity Made Of? In this video blog, physicist Greg Kestin describes the 2014 results from the BICEP2 experiment and their implications for gravitons and quantum gravity.

The Physics Teacher: Extra Dimensions of Space Author Don Lincoln explains what physicists talk about when they talk about extra dimensions.

Poincare Prize Lecture: Is a Graviton Detectable? In this technical lecture, eminent theorist Freeman Dyson asks whether it will ever be possible to detect gravitons.

Warped Passages: Unraveling the Mysteries of the Universe’s Hidden Dimensions In this popular book, Harvard physicist Lisa Randall explains why theorists believe extra dimensions may exist, and how we might find them.

Don Lincoln

Don Lincoln is a senior experimental particle physicist at Fermi National Accelerator Laboratory and an adjunct professor at the University of Notre Dame. He splits his research time between Fermilab and the CERN laboratory, just outside Geneva, Switzerland. He has coauthored more than 500 scientific papers on subjects from microscopic black holes and extra dimensions to the elusive Higgs boson. When Don isn’t doing physics research, he spends his time sharing the fantastic world of science with anyone who will listen. He has given public lectures on three continents and has authored many magazine articles, YouTube videos and columns in the online periodical Fermilab Today. His most recent book "The Large Hadron Collider: The Extraordinary Story of the Higgs Boson and Other Stuff That Will Blow Your Mind" tells the tale of the Large Hadron Collider, the physics and the technology required to make it all work, and the human stories behind the hunt for the Higgs boson.

is it possible that gravitons are the gray matter that we search for?

True to a degree. However, you have made a historical statement. The gravitational field as we understand it is wholly contained within Newton’s work. We just think of it differently nowadays. Thus I stand by the statement in the article as it hinged on the understanding of gravity rather than the field concept. Essentially the Newton insight was more central to the point that the field one.

Thanks for another great article Dr. Lincoln. The notion of quantized gravity in the spotlight due to the recently published research has me asking questions about how we came to understand any of the forces as quantized. In my head I envision a wall being peppered with pellets like in the double-slit experiment. I’m not quite sure even how to ask the question…but what does it mean to be quantized? What actually separates one particle from another? Empty space? We know now space isnt empty. What does this mean for what is happening in the empty space between particles in a stream? I guess this questions begs more fundamental question…why is anything quantized? Is the quantum nature of reality objectively real or have we imposed this “nature” upon reality because, by definition, to study something you must have a discrete “thing”/particle to study?

Regarding gravity’s relative weakness in comparison to the other forces, I am reminded that in the singularity prior to the Big Bang the forces were united. If a large portion of gravity’s strength is bound in smaller dimensions could it in fact be appearing or manifesting as, say, the strong nuclear force?

Just some brief thoughts.

If you drop a pebble in water, you’ll see a localized wave pattern travel across the water. This is a quantized wave. This is in contrast to the continuous stream of waves that hits a shoreline. And we certainly know that matter is quantized. We can manipulate individual atoms. Further, we can extract individual electrons, protons or neutrons. It’s harder to see when talking about energy, but not fundamentally different.

Regarding the gravity moving into extra dimensions being the strong nuclear force…I dunno…probably not, but we don’t have a theory of quantum gravity, so it’s hard to say anything definitively. I guess I think your implied proposal is unlikely, but I’ll hedge with a shrug and a beatstheheckouttame. We’ll have to wait for a clever lad or lass to come up with a good theory of quantum gravity and go from there.

LOL! Sounds like a plan. Re: quanta, thank you, your analogy helped me understand the concept much better. Am I correct though in understanding that the distinction between the causes of these waves, the pebble and the wind respectively, and the waves themselves being particles of water moving in a certain pattern, is where the analogy breaks down? Because, at the subatomic level we’re discussing, in some mysterious way both the particle (localized “center” of the wave) is made of the same ‘stuff’ as the wave itself and they are, in fact, one? Or maybe I should just understand it the way we talk about electromagnetism – the force we care all most familiar with – that with charge comes a field called magnetism that behaves in a wave like way, and that it doesn’t make sense to speak of one without the other? Is this the more accurate way to conceptualize the wave-particle duality?

I’m afraid I didn’t understand that well enough to answer.

I was just trying to point out that in the analogy the pebble and the waves it creates are two separate things whereas, at the subatomic level, the particle and wave are the same thing, two sides of the same coin so to speak. And, in fact, that a single particle is also a wave. I’m referencing the paradox in the double-split experiment of how a single photon/particle can produce a wave pattern when, accd to everyday experience, it takes multiple particles to create a wave pattern. As far as I understand it – or think I understand it – the wave is the field (or perhaps put another way, the “range of influence” of the particle) by which the particle interacts with other particles. And that the particle, per your analogy, is at the “center” of the wave pattern. I was just wondering if I am understanding this wave-particle duality correctly, making the concept more difficult than it is or if there is still something I am missing.

It is true that the pebble and the ripple are different, but they do not well represent the particle/wave dichotomy. A traditional wave goes on forever and ever…like a sine wave. A particle has a fixed position. A ripple is a localized wave. Thus the ripple has both particle and wave properties. That was the analogy I was trying to make.

Ahhh…that really makes sense. I get it now.

Thanks so much for your time and continuing engagment with the public in this forum. I appreciate very much that a scientist of your stature is willing to help the public understand the wonders of the universe.

Glad it helped. I can’t always answer every question, but it’s nice when I can. Keep learning.

The photon bends because the space is bent, not because there is a force “pulling or pushing” it. Gravity bends space and the photon travels straight through the bent space.

One other graviton theory is Aspin Bubbles, short for Anaharmic Spin I surmise. This theory “suggests that electrical forces among singly charged elementary particles are simply mechanical forces coming from a single mechanical interaction between anharmonic waves and particle” [“aspin Bubbles” and the Force of Gravity: Yoel Lana-Renault; Infinite Energy Vol 20 Issue 115 2014]. Explains gravity outside of any Time Dimension. Time dimension is fundamental to General Relativity (and BB).

Related to the BB I would suggest Hilton Ratcliffe ‘The Static Universe’ to any students as an antidote to High School and University BB indoctrination. The falsity of the BB is in the total absence of any astrophysics supporting the BB. Also, Hubble Red shift has been abandoned by BB theory as portraying any Universe Expansion, as Hubble claimed as well.

“Like massless photons, gravitons should travel at the speed of light. ” Why this assumption? Where did that come from?

“No mass” means you are traveling at light speed. “Mass” means you are traveling at less than light speed. The gravitons should decay very quickly if they are traveling slower than light speed. If the graviton has no mass, then light speed it is.

A magnet will hold a paperclip against the Earth’s gravity.

“There are other gravitational force which are acting against earth’s gravity (Like moon, sun, other planets and even stars) that is why it appears weak.”

Fosamax - Woman S Health, Alendron-Hexal

Fosamax is in the group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body. Fosamax slows bone loss while increasing bone mass, which may prevent bone fractures.

Take Fosamax exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Fosamax tablets are taken either once each day or once each week.

Take the Fosamax tablet first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. If you take a Fosamax tablet only once a week, take it on the same day each week and always first thing in the morning.

Take each Fosamax tablet with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking a tablet. Do not crush, chew, or suck the Fosamax tablet. Swallow the pill whole.

After taking a Fosamax tablet, carefully follow these instructions: Do not lie down or recline for at least 30 minutes after taking Fosamax. Do not eat or drink anything other than plain water. Do not take any other medicines including vitamins, calcium, or antacids for at least 30 minutes after taking Fosamax. It may be best to take your other medicines at a different time of the day. Talk with your doctor about the best dosing schedule for your other medicines.

To be sure Fosamax is helping your condition, your bone mineral density will need to be tested on a regular basis. Visit your doctor regularly.

If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using this medicine. You may need to stop using the medicine for a short time.

Fosamax is only part of a complete program of treatment that may also include diet changes, exercise, and taking calcium and vitamin supplements. Follow your diet, medication, and exercise routines very closely.

If you take Fosamax tablets once daily: If you forget to take this medicine first thing in the morning, do not take it later in the day. Wait until the following morning to take the medicine and skip the missed dose. Do not take two (2) tablets in one day.

If you take Fosamax tablets once a week: If you forget to take Fosamax on your scheduled day, take it first thing in the morning on the day after you remember the missed dose. Then return to your regular weekly schedule on your chosen dose day. Do not take two (2) tablets in one day.

Treatment of Osteoporosis in Postmenopausal Women

The recommended dosage is: one 70 mg tablet once weekly one bottle of 70 mg oral solution once weekly one 10 mg tablet once daily

Prevention of Osteoporosis in Postmenopausal Women

The recommended dosage is: one 35 mg tablet once weekly one 5 mg tablet once daily

Treatment to Increase Bone Mass in Men with Osteoporosis

The recommended dosage is: one 70 mg tablet once weekly one bottle of 70 mg oral solution once weekly one 10 mg tablet once daily

Treatment of Glucocorticoid-Induced Osteoporosis

The recommended dosage is one 5 mg tablet once daily, except for postmenopausal women not receiving estrogen, for whom the recommended dosage is one 10 mg tablet once daily.

Treatment of Paget's Disease of Bone

The recommended treatment regimen is 40 mg once a day for six months.

Store at room temperature away from moisture and heat.

Do not take a Fosamax tablet if you cannot sit upright or stand for at least 30 minutes. Fosamax can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). You will need to stay upright for at least 30 minutes after taking this medication.

You should not take Fosamax if you are allergic to alendronate, or if you have low levels of calcium in your blood (hypocalcemia), or a problem with the movement of muscles in your esophagus.

To make sure you can safely take Fosamax, tell your doctor if you have any of these other conditions:

trouble swallowing;

a vitamin D deficiency;

a dental problem;

kidney disease; or

an ulcer or other problem in your stomach or esophagus.

Some people using medicines similar to Fosamax have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums.

You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and dental surgery or pre-existing dental problems.

Talk with your doctor about the risks and benefits of using Fosamax.

FDA pregnancy category C. It is not known whether Fosamax will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether alendronate passes into breast milk or if it could harm a nursing baby. Do not use Fosamax without telling your doctor if you are breast-feeding a baby.

Get emergency medical help if you have any of these signs of an allergic reaction to Fosamax: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Fosamax and call your doctor at once if you have any of these serious side effects:

chest pain;

difficulty or pain when swallowing;

pain or burning under the ribs or in the back;

severe heartburn, burning pain in your upper stomach, or coughing up blood;

new or worsening heartburn;

fever, body aches, flu symptoms;

severe joint, bone, or muscle pain;

new or unusual pain in your thigh or hip;

jaw pain, numbness, or swelling.

Less serious Fosamax side effects may include:

mild heartburn, bloating;

mild nausea, vomiting, or stomach pain;

diarrhea, gas, or constipation;

mild joint pain or swelling;

swelling in your hands or feet; or

dizziness, eye pain, headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Fosamax is in the group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body. Fosamax slows bone loss while increasing bone mass, which may prevent bone fractures.

Take Fosamax exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Fosamax tablets are taken either once each day or once each week.

Take the Fosamax tablet first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. If you take a Fosamax tablet only once a week, take it on the same day each week and always first thing in the morning.

Take each Fosamax tablet with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking a tablet. Do not crush, chew, or suck the Fosamax tablet. Swallow the pill whole.

After taking a Fosamax tablet, carefully follow these instructions: Do not lie down or recline for at least 30 minutes after taking Fosamax. Do not eat or drink anything other than plain water. Do not take any other medicines including vitamins, calcium, or antacids for at least 30 minutes after taking Fosamax. It may be best to take your other medicines at a different time of the day. Talk with your doctor about the best dosing schedule for your other medicines.

To be sure Fosamax is helping your condition, your bone mineral density will need to be tested on a regular basis. Visit your doctor regularly.

If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using this medicine. You may need to stop using the medicine for a short time.

Fosamax is only part of a complete program of treatment that may also include diet changes, exercise, and taking calcium and vitamin supplements. Follow your diet, medication, and exercise routines very closely.

If you take Fosamax tablets once daily: If you forget to take this medicine first thing in the morning, do not take it later in the day. Wait until the following morning to take the medicine and skip the missed dose. Do not take two (2) tablets in one day.

If you take Fosamax tablets once a week: If you forget to take Fosamax on your scheduled day, take it first thing in the morning on the day after you remember the missed dose. Then return to your regular weekly schedule on your chosen dose day. Do not take two (2) tablets in one day.

Treatment of Osteoporosis in Postmenopausal Women

The recommended dosage is: one 70 mg tablet once weekly one bottle of 70 mg oral solution once weekly one 10 mg tablet once daily

Prevention of Osteoporosis in Postmenopausal Women

The recommended dosage is: one 35 mg tablet once weekly one 5 mg tablet once daily

Treatment to Increase Bone Mass in Men with Osteoporosis

The recommended dosage is: one 70 mg tablet once weekly one bottle of 70 mg oral solution once weekly one 10 mg tablet once daily

Treatment of Glucocorticoid-Induced Osteoporosis

The recommended dosage is one 5 mg tablet once daily, except for postmenopausal women not receiving estrogen, for whom the recommended dosage is one 10 mg tablet once daily.

Treatment of Paget's Disease of Bone

The recommended treatment regimen is 40 mg once a day for six months.

Store at room temperature away from moisture and heat.

Do not take a Fosamax tablet if you cannot sit upright or stand for at least 30 minutes. Fosamax can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). You will need to stay upright for at least 30 minutes after taking this medication.

You should not take Fosamax if you are allergic to alendronate, or if you have low levels of calcium in your blood (hypocalcemia), or a problem with the movement of muscles in your esophagus.

To make sure you can safely take Fosamax, tell your doctor if you have any of these other conditions:

trouble swallowing;

a vitamin D deficiency;

a dental problem;

kidney disease; or

an ulcer or other problem in your stomach or esophagus.

Some people using medicines similar to Fosamax have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums.

You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and dental surgery or pre-existing dental problems.

Talk with your doctor about the risks and benefits of using Fosamax.

FDA pregnancy category C. It is not known whether Fosamax will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether alendronate passes into breast milk or if it could harm a nursing baby. Do not use Fosamax without telling your doctor if you are breast-feeding a baby.

Get emergency medical help if you have any of these signs of an allergic reaction to Fosamax: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Fosamax and call your doctor at once if you have any of these serious side effects:

chest pain;

difficulty or pain when swallowing;

pain or burning under the ribs or in the back;

severe heartburn, burning pain in your upper stomach, or coughing up blood;

new or worsening heartburn;

fever, body aches, flu symptoms;

severe joint, bone, or muscle pain;

new or unusual pain in your thigh or hip;

jaw pain, numbness, or swelling.

Less serious Fosamax side effects may include:

mild heartburn, bloating;

mild nausea, vomiting, or stomach pain;

diarrhea, gas, or constipation;

mild joint pain or swelling;

swelling in your hands or feet; or

dizziness, eye pain, headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Fosamax is in the group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body. Fosamax slows bone loss while increasing bone mass, which may prevent bone fractures.

Take Fosamax exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Fosamax tablets are taken either once each day or once each week.

Take the Fosamax tablet first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. If you take a Fosamax tablet only once a week, take it on the same day each week and always first thing in the morning.

Take each Fosamax tablet with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking a tablet. Do not crush, chew, or suck the Fosamax tablet. Swallow the pill whole.

After taking a Fosamax tablet, carefully follow these instructions: Do not lie down or recline for at least 30 minutes after taking Fosamax. Do not eat or drink anything other than plain water. Do not take any other medicines including vitamins, calcium, or antacids for at least 30 minutes after taking Fosamax. It may be best to take your other medicines at a different time of the day. Talk with your doctor about the best dosing schedule for your other medicines.

To be sure Fosamax is helping your condition, your bone mineral density will need to be tested on a regular basis. Visit your doctor regularly.

If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using this medicine. You may need to stop using the medicine for a short time.

Fosamax is only part of a complete program of treatment that may also include diet changes, exercise, and taking calcium and vitamin supplements. Follow your diet, medication, and exercise routines very closely.

If you take Fosamax tablets once daily: If you forget to take this medicine first thing in the morning, do not take it later in the day. Wait until the following morning to take the medicine and skip the missed dose. Do not take two (2) tablets in one day.

If you take Fosamax tablets once a week: If you forget to take Fosamax on your scheduled day, take it first thing in the morning on the day after you remember the missed dose. Then return to your regular weekly schedule on your chosen dose day. Do not take two (2) tablets in one day.

Treatment of Osteoporosis in Postmenopausal Women

The recommended dosage is: one 70 mg tablet once weekly one bottle of 70 mg oral solution once weekly one 10 mg tablet once daily

Prevention of Osteoporosis in Postmenopausal Women

The recommended dosage is: one 35 mg tablet once weekly one 5 mg tablet once daily

Treatment to Increase Bone Mass in Men with Osteoporosis

The recommended dosage is: one 70 mg tablet once weekly one bottle of 70 mg oral solution once weekly one 10 mg tablet once daily

Treatment of Glucocorticoid-Induced Osteoporosis

The recommended dosage is one 5 mg tablet once daily, except for postmenopausal women not receiving estrogen, for whom the recommended dosage is one 10 mg tablet once daily.

Treatment of Paget's Disease of Bone

The recommended treatment regimen is 40 mg once a day for six months.

Store at room temperature away from moisture and heat.

Do not take a Fosamax tablet if you cannot sit upright or stand for at least 30 minutes. Fosamax can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). You will need to stay upright for at least 30 minutes after taking this medication.

You should not take Fosamax if you are allergic to alendronate, or if you have low levels of calcium in your blood (hypocalcemia), or a problem with the movement of muscles in your esophagus.

To make sure you can safely take Fosamax, tell your doctor if you have any of these other conditions:

trouble swallowing;

a vitamin D deficiency;

a dental problem;

kidney disease; or

an ulcer or other problem in your stomach or esophagus.

Some people using medicines similar to Fosamax have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums.

You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and dental surgery or pre-existing dental problems.

Talk with your doctor about the risks and benefits of using Fosamax.

FDA pregnancy category C. It is not known whether Fosamax will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether alendronate passes into breast milk or if it could harm a nursing baby. Do not use Fosamax without telling your doctor if you are breast-feeding a baby.

Get emergency medical help if you have any of these signs of an allergic reaction to Fosamax: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Fosamax and call your doctor at once if you have any of these serious side effects:

chest pain;

difficulty or pain when swallowing;

pain or burning under the ribs or in the back;

severe heartburn, burning pain in your upper stomach, or coughing up blood;

new or worsening heartburn;

fever, body aches, flu symptoms;

severe joint, bone, or muscle pain;

new or unusual pain in your thigh or hip;

jaw pain, numbness, or swelling.

Less serious Fosamax side effects may include:

mild heartburn, bloating;

mild nausea, vomiting, or stomach pain;

diarrhea, gas, or constipation;

mild joint pain or swelling;

swelling in your hands or feet; or

dizziness, eye pain, headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Adepril - Drug Review Dosage, Side Effects, Action, Buy Adepril, Adepril

Adepril

Adepril review

Adepril is an effective, popular medication that battles depression. It is considered a tricyclic antidepressant medication. By inhibiting the serotonin and the noradrenaline reuptake in a persons body, Adepril actually increases the levels of those natural body chemicals so that the levels of depression decrease. It is usually sold under the names Elavil. Tryptanol, Endep. Elatrol, Tryptizol, Trepiline, and Laroxyl. It also has sedative effects, so it can be used to calm people with anxiety or violent depression. Adepril is typically used by doctors to treat clinical depression and depression in the elderly; however, in some countries it is used to treat chronic migraines. chronic pain, carpal tunnel syndrome and insomnia. A medical study done in 2003 compared Adepril with a control group of anti depressants, and almost 90% of the subjects had a more favorable response with Adepril.

The most common side effects are dry mouth. drowsiness, dizziness. blurred vision, insomnia and weight gain. Because of the drowsiness and dizziness that people experience while taking this medication, most patients are discouraged from driving or operating heavy machinery while on Adepril. The side effects previously mentioned are the common side effects of the medication, but in some rare cases people may experience mania, hypotension, psychosis. and hepatic toxicity. If you experience any of these rare symptoms you should inform your doctor immediately.

People who have a history of seizures, liver illnesses, blood illnesses, hyperthyroidism. constipation and glaucoma should inform their doctor of their condition before taking Adepril. Any of these illnesses may hinder the medication. Patients with heart disease should be particularly careful because this medication can cause abnormal rhythms in the heart. Patients with bipolar disorder might experience hypermaniac attacks if given Adepril, doctors might want to adjust the dose or prescribe a different medication. The use of Adepril hasn't been cleared for pregnant women, and it also is passed through breast milk so mothers should not nurse their children while they are on the medication.

Patients should also tell their doctor about any medication that they are taking before they try Adepril. Medications like cisapride. monoamine oxidase inhibitors, Marplan, Nardil, Eldepryl, Emsam, Zelapar and Parnate have negative effects when combined with Adepril. Any medication you are on might react badly with Adepril, even simple medications like sleeping pills, antihistamines, diet pills, herbal vitamins, or anything like that might react badly with Adepril and be a cause for trouble. Giving your doctor a complete medical and medication history is a must.

Adepril should only be taken as prescribed by your doctor. The pills are small, white and odorless. They come in 10, 25, 50 and 70 mg pills. The dose for adults and the elderly is typically 25 to 150 mg daily depending on the severity of the condition being treated. It is very important to take the dose recommended by your doctor, as too much might affect your mental health adversely and not positively.

Adepril has the following structural formula:

• Molecular formula of adepril is C20H23N • Chemical IUPAC Name is 3-(10,11-dihydro-5H-dibenzo-[a, d]cyclohepten-5-ylidene)-N, N-dimethyl-1-propanamine • Molecular weight is 277.403 g/mol • Adepril available. 10mg tablets, 25mg tablets, 50mg tablets, 75mg tablets, 100mg tablets, 150mg tablets

Generic name: Amitriptyline

Aciclovir - Anti Viral, Aciclomed

Common use Aciclovir is an antiviral drug, it is a synthetic ingredient with a similar molecular structure to purine nucleoside. Aciclovir is used to treat viral infections such as cold sores, to stop the growth of Herpes simplex virus, Varicella zoster virus (caused by chickenpox and shingles), Epstein Barr Virus (caused by glandular fever), and to a lesser extent Cytomegalovirus (CMV). It is also useful in preventing genital herpes and in preventing viral infections occurring in those with a lowered immune system. This medication may also help reduce the time when pain remains after the sores heal. In addition, in people with a weakened immune system, Aciclovir can decrease the risk of the virus spreading to other parts of the body and causing serious infections.

Dosage and direction

Take this medication by mouth with or without food, usually 2 to 5 times a day as directed by your doctor. Take this medicine by mouth with a glass of water. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think your are better. If you are using the liquid form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Dosage is based on your medical condition and response to treatment. In children, dosage is also based on weight.

You should talk with your healthcare provider prior to taking Aciclovir if you have kidney disease, including kidney failure (renal failure), any allergies, including allergies to food, dyes, or preservatives. Let your healthcare provider know if you are pregnant or thinking of becoming pregnant, breastfeeding. Make sure to tell your healthcare provider about all medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. The medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug.

Aciclovir Injection is contraindicated for patients who develop hypersensitivity to Aciclomed or valaciclovir.

Possible side effects Side effects are potentially serious and you should report to your doctor or health care professional as soon as possible. These include, but are not limited to: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, chest pain, confusion, hallucinations, tremor, dark urine, increased sensitivity to the sun, redness, blistering, peeling or loosening of the skin (including inside the mouth), seizures, trouble passing urine or change in the amount of urine, unusual bleeding or bruising, or pinpoint red spots on the skin, unusually weak or tired, yellowing of the eyes or skin. Side effects that usually do not require medical attention: diarrhea, fever, headache, nausea, vomiting stomach upset. In this way report to your doctor or health care professional if they continue or are bothersome.

Drug interactions There are negative interactions that can occur when Aciclovir is combined with any of the drugs listed above. Phenytoin (Fosphenytoin) and Aciclovir: it may decrease the level of phenytoin in your blood, perhaps making it less effective. Your healthcare provider may need to measure the level of phenytoin in your blood (using a blood test) and adjust your dose as necessary. Probenecid can increase the level of Aciclovir in your blood, increasing your risk of acyclovir side effects. Your healthcare provider may need to decrease your acyclovir dosage to prevent this interaction from occurring. Acyclovir can increase the level of Tenofovir in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to lower your tenofovir dosage to prevent drug interactions.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include seizure (convulsions), hallucinations, and urinating less than usual or not at all.

Store at controlled room temperature of 15°C to 25°C (59°F to 77°F). Keep this medicine out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use Aciclovir is an antiviral drug, it is a synthetic ingredient with a similar molecular structure to purine nucleoside. Aciclovir is used to treat viral infections such as cold sores, to stop the growth of Herpes simplex virus, Varicella zoster virus (caused by chickenpox and shingles), Epstein Barr Virus (caused by glandular fever), and to a lesser extent Cytomegalovirus (CMV). It is also useful in preventing genital herpes and in preventing viral infections occurring in those with a lowered immune system. This medication may also help reduce the time when pain remains after the sores heal. In addition, in people with a weakened immune system, Aciclovir can decrease the risk of the virus spreading to other parts of the body and causing serious infections.

Dosage and direction

Take this medication by mouth with or without food, usually 2 to 5 times a day as directed by your doctor. Take this medicine by mouth with a glass of water. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think your are better. If you are using the liquid form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Dosage is based on your medical condition and response to treatment. In children, dosage is also based on weight.

You should talk with your healthcare provider prior to taking Aciclovir if you have kidney disease, including kidney failure (renal failure), any allergies, including allergies to food, dyes, or preservatives. Let your healthcare provider know if you are pregnant or thinking of becoming pregnant, breastfeeding. Make sure to tell your healthcare provider about all medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. The medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug.

Aciclovir Injection is contraindicated for patients who develop hypersensitivity to aciclovir or valaciclovir.

Possible side effects Side effects are potentially serious and you should report to your doctor or health care professional as soon as possible. These include, but are not limited to: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, chest pain, confusion, hallucinations, tremor, dark urine, increased sensitivity to the sun, redness, blistering, peeling or loosening of the skin (including inside the mouth), seizures, trouble passing urine or change in the amount of urine, unusual bleeding or bruising, or pinpoint red spots on the skin, unusually weak or tired, yellowing of the eyes or skin. Side effects that usually do not require medical attention: diarrhea, fever, headache, nausea, vomiting stomach upset. In this way report to your doctor or health care professional if they continue or are bothersome.

Drug interactions There are negative interactions that can occur when Aciclovir is combined with any of the drugs listed above. Phenytoin (Fosphenytoin) and Aciclovir: it may decrease the level of phenytoin in your blood, perhaps making it less effective. Your healthcare provider may need to measure the level of phenytoin in your blood (using a blood test) and adjust your dose as necessary. Probenecid can increase the level of Aciclovir in your blood, increasing your risk of acyclovir side effects. Your healthcare provider may need to decrease your acyclovir dosage to prevent this interaction from occurring. Acyclovir can increase the level of Tenofovir in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to lower your tenofovir dosage to prevent drug interactions.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include seizure (convulsions), hallucinations, and urinating less than usual or not at all.

Store at controlled room temperature of 15°C to 25°C (59°F to 77°F). Keep this medicine out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Buy Solusedante Loratadine Online Without Prescriptions, Solusedante

Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Alavert is used for relieving symptoms of seasonal allergies.

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Do not crush, chew, or break the regular loratadine tablet. Swallow the pill whole. Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon.

Alavert is usually taken once per day. Follow your doctor's instructions.

To take Alavert orally disintegrating tablet:

Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet.

Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

Using dry hands, remove the tablet and place it on your tongue. It will begin to dissolve right away.

Take Alavert by mouth with food.

Store at room temperature between 20 and 25 degrees C and away from moisture, light and heat. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Alavert out of the reach of children and away from pets.

You should not take Alavert if:

You are allergic to loratadine or to desloratadine (Clarinex). Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

kidney disease; Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

You should not take this medication if you are allergic to loratadine or to desloratadine (Clarinex).

FDA pregnancy category B: This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Loratadine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Loratadine disintegrating tablets (Claritin Reditab, Alavert) may contain phenylalanine. Talk to your doctor before using this form of loratadine if you have phenylketonuria (PKU). Do not give this medication to a child younger than 6 years old without the advice of a doctor.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

fast or uneven heart rate;

feeling like you might pass out;

jaundice (yellowing of your skin or eyes);

seizures (convulsions).

Call your doctor at once if you noticed these serious side effects. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

headache;

skin rash;

nervousness;

nosebleed;

feeling tired or drowsy;

eye redness, blurred vision;

stomach pain, diarrhea;

dry mouth, sore throat hoarseness.

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Deturgylone, Deturgylone

Prednisolone is used for treating allergies, arthritis, breathing problems (e. g. asthma), certain blood disorders, collagen diseases (e. g. lupus), certain eye diseases (e. g. keratitis), cancer (e. g. leukemia), endocrine problems (e. g. adrenocortical insufficiency), intestinal problems (e. g. ulcerative colitis), swelling due to certain conditions, or skin conditions (e. g. psoriasis).

Availability: In Stock (34 packs)

Prednisolone is used for treating allergies, arthritis, breathing problems (e. g. asthma), certain blood disorders, collagen diseases (e. g. lupus), certain eye diseases (e. g. keratitis), cancer (e. g. leukemia), endocrine problems (e. g. adrenocortical insufficiency), intestinal problems (e. g. ulcerative colitis), swelling due to certain conditions, or skin conditions (e. g. psoriasis). It may also be used for other conditions as determined by your doctor.

Use Prednisolone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Prednisolone by mouth with or without food. Swallow Prednisolone whole. Do not break, crush, or chew before swallowing. Continue taking Prednisolone even if you feel good. Do not miss any doses.

Drug Class and Mechanism

Prednisolone is a corticosteroid. It works by modifying the body's immune response to various conditions and decreasing inflammation.

If you miss a dose of Prednisolone, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Store Prednisolone at 77 degrees F (25 degrees C). Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prednisolone out of the reach of children and away from pets.

Do not use Prednisolone if:

you are allergic to any ingredient of Prednisolone; you have a systemic fungal infection, a certain type of malaria, inflammation of the optic nerve, or herpes infection of the eye; you are scheduled to have a live or attenuated live vaccination (eg, smallpox); you are taking mifepristone. Contact your doctor or health care provider right away if any of these apply to you.

Important: Prednisolone may lower the ability of your body to fight infection. Avoid contacts with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills. If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does. If you are taking Prednisolone regularly over a long period of time, carry an ID card at all times that says you take Prednisolone. Do not receive a live vaccine (eg, measles, mumps) while you are taking Prednisolone. Talk with your doctor before you receive any vaccine. Tell your doctor or dentist that you take Prednisolone before you receive any medical or dental care, emergency care, or surgery. Diabetes patients - Prednisolone may affect your blood sugar. Check blood sugar levels. Ask your doctor before you change the dose of your diabetes medicine. Lab tests, including adrenal function tests, may be performed while you use Prednisolone. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Caution is advised when using Prednisolone in children; they may be more sensitive to its effects. Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they take Prednisolone. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prednisolone while you are pregnant. Prednisolone is found in breast milk. If you are or will be breast-feeding while you use Prednisolone, check with your doctor. Discuss any possible risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

acne; clumsiness; dizziness; facial flushing; feeling of a whirling motion; general body discomfort; headache; increased appetite; increased sweating; nausea; nervousness; sleeplessness; upset stomach. Seek medical attention right away if any of these severe side effects occur: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual period; changes in skin color; chest pain; easy bruising or bleeding; infection (e. g. fever, chills, sore throat); mental or mood changes (e. g. depression); muscle pain, weakness, or wasting; seizures; severe nausea or vomiting; sudden severe dizziness or headache; swelling of feet or legs; tendon or bone pain; thinning of skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

Prednisolone is to be used only by the patient for whom it is prescribed. Do not share it with other people.

Napro, Napro

Infertility

Infertility is a symptom of underlying disease. The diseases that cause infertility have a “two-pronged” effect. They not only hinder the functioning of fertility, but they also cause both short and long-term health problems. The persistent unwillingness to address infertility problems from this point of view or perspective is one of the major flaws in the current approach to the treatment of infertility.

Fertility problems also carry with them significant emotional sequelae. This is fairly well recognized by those who work in this field and psychosocial distress can contribute significantly to the cause of some forms of infertility.

Until 1978, most of the effort in medicine in evaluating and treating women with infertility was placed in trying to identify and treat the underlying causes. In 1978, in vitro fertilization produced a paradigm shift. It led to a “skipping over” the causes and this continues up to the present time to be the foundational management approach. In essence, this is a symptomatic or Band-Aid approach to treatment, not one that gets to the root causes. When the artificial reproductive technologies began to take hold, now over 25 years ago, diagnostic laparoscopy was in its infancy. Hormone assessment, while available, was not readily accessible. Ultrasound technology was still mired in sector scanning and real-time ultrasonography was not yet available. Selective hysterosalpingography had not yet been developed and the fallopian tubes could not be catheterized. The Creighton Model Fertility Care ™ System began its first Allied Health Education Program for Fertility Care ™ Practitioners (FCP) in 1978. This means of objectively monitoring the biomarkers of the menstrual and fertility cycle was only in its beginning stages. With the availability of the CrMS, observations of mucus patterns during the course of the menstrual and fertility cycle could be observed for the very first time. In fact, information obtained by women charting their cycles in this fashion is unique and can only be obtained in this fashion. In Figure 40-2, a normal cycle with a normal mucus pattern, Peak Day and post-Peak phase is illustrated. In addition, the estrogen levels (black bars) and progesterone levels (red bars) are also shown to demonstrate the correlation to underlying hormonal events.

[Figure 40-2, p. 511 from the NaPro textbook. A normal CrMS chart with daily levels of E2 and progesterone. The hormonal profiles are normal. The mucus cycle score is 15.7 and post-Peak phase is 10 days (From: Pope Paul VI Institute research, 2004).]

In the next cycle, a completely dry cycle is observed. No mucus is observed during the course of the entire cycle. These dry cycle patterns occur in about 15 percent of all women with regular cycles and infertility. Looking at the underlying hormonal correlations (Figure 40-3), one can see that the estrogen and progesterone levels are significantly suboptimal compared to the levels observed in the normal cycle (Figure 40-2). This suggests that the dry cycles – the absence of mucus – are a reflection of underlying hormonal abnormalities. We now know that this is an exhibition of abnormal folliculogenesis and abnormal luteogenesis (abnormal development of the follicle with a subsequent abnormal corpus luteum). This is also associated with abnormal ovulation events.

[Figure 40-3 from p. 511 from the NaPro textbook. An infertility patient with a dry cycle and daily levels of E2 and progesterone. Both the preovulatory and the postovulatory profiles are very suboptimal revealing very poor folliculogenesis followed by abnormal luteogenesis (From: Pope Paul VI Institute research, 2004).]

The Goals of NaProTECHNOLOGY in Infertility

A NaProTECHNOLOGY approach to the infertile couple has the following goals:

It works towards assessing the underlying causes of the reproductive abnormality.

It allows for the treatment of these underlying causes.

It assists the couple in achieving pregnancy while maintaining the natural acts of procreation.

If the treatment program is unsuccessful, research into the unknown causes is undertaken.

If medically unsuccessful, the program will assist with successful family building by being supportive of adoption.

The use of a NaProTECHNOLOGY approach to infertility or miscarriage will also allow us to observe events that formerly had been ignored. An example of this might be that found in Figure 40-7. Here a woman with four consecutive miscarriages has charted her cycle. She has multiple days of premenstrual spotting prior to the beginning of her next period. The hormonal correlation shows a significantly reduced progesterone production by the corpus luteum suggesting an inadequate corpus luteum as one of the underlying causes of her repetitive miscarriages.

[Figure 40-7 on p. 514 from the NaPro textbook. A woman with premenstrual spotting, a history of four consecutive spontaneous abortions and a preovulatory and postovulatory hormone profile. The periovulatory estradiol levels are decreased but what is most remarkable is the significant decrease in postovulatory progesterone (From: Pope Paul VI Institute research, 2004).]

A staircase approach outlining the basic principles of NaProTECHNOLOGY for the evaluation and treatment of infertility is shown in Figure 40-8.

[Figure 40-8 on p. 516 from the NaPro textbook. A staircase approach outlining the basic principles of a NaProTECHNOLOGY evaluation protocol for infertility. Evaluation and treatment protocol for infertility.]

Several examples of successful outcomes in patients with infertility are shown in the next series of charts.

Case No. 1: In this patient with dry cycles and seven years of infertility, Vitamin B6 was recommended as a mucus enhancing supplement. In the last cycle, limited mucus was observed and pregnancy achieved without any additional assistance except fertility-focused intercourse (from Pope Paul VI Institute research, 2004).

[Figure 40-24 on p. 537 from the NaPro textbook. In this patient with dry cycles and seven years of infertility, vitamin B6 was recommended as a mucus-enhancing supplement. In the last cycle, limited mucus was observed and pregnancy achieved without any additional assistance except fertility focused intercourse (From: Pope Paul VI Institute research, 2004).]

Case No. 2: In this case, the patient, who previously lost sextuplets from an ART procedure at nearly 20 weeks of pregnancy, shows here CrMS chart which is strikingly consistent with polycystic ovarian disease (Figure 40-25).

[Figure 40-25 from the NaPro textbook. This patient, who previously lost sextuplets from an ART procedure, shows her CrMS chart which is strikingly consistent with polycystic ovarian disease (From: Pope Paul VI Institute).]

Case No. 3: The limited mucus cycles, endometriosis, ovarian dysfunction and a husband with a very low sperm count were identified in this patient who had failed two previous IVF procedures. In spite of these abnormalities, with proper NaProTECHNOLOGY treatment, she achieved a pregnancy and had a normal healthy baby (from Pope Paul VI Institute).

[Figure 40-26 on p. 538 from the NaPro textbook. Limited mucus cycles, endometriosis, ovarian dysfunction and a husband with a very low sperm count were identified in this patient who failed two previous IVF procedures. In spite of these abnormalities with proper NaProTECHNOLOGY treatment, she achieved a pregnancy and had a normal healthy baby (From: Pope Paul VI Institute).]

Effectiveness For Infertility Treatment

Using a NaProTECHNOLOGY approach for the treatment of infertility can be highly effective and even more effective than current approaches to infertility. In Figure 51-5, a life table comparison of the effectiveness of NaProTECHNOLOGY (in blue) with a similar non-NaProTECHNOLOGY approach taken at Johns Hopkins University is shown. The success rates are clearly better using the NaProTECHNOLOGY approach.

[Figure 51-5, p. 682 from the NaPro textbook. Cumulative pregnancy rate of patients with endometriosis treated with NaProTECHNOLOGY compared to conservative surgery only. Patients with normospermic husbands only (From: Pope Paul VI Institute research, 2004 and Rock JA, Guzick DS, Sengos C, et al: The Conservative Surgical Treatment of Endometriosis: Evaluation of Pregnancy Success with Respect to the Extent of Disease as Categorized Using Contemporary Classification Systems. Fertil Steril 35:131-137, 1981).]

A similar study showing a comparison of a NaProTECHNOLOGY approach to the treatment of women who have polycystic ovarian disease and comparing it to the work at Johns Hopkins University also shows a significant improvement (Figure 51-13).

[Figure 51-13, p. 683 from the NaPro textbook. Cumulative pregnancy rate for patients with polycystic ovarian disease treated with NaProTECHNOLOGY compared to surgical wedge resection only. (From: Pope Paul VI Institute research, 2004 and Adashi EY, Rock JA, Guzick D, et al: Fertility Following Bilateral Ovarian Wedge Resection: A Critical Analysis of 90 Consecutive Cases of the Polycystic Ovary Syndrome. Fertil Steril 36:320-325, 1981).]

In Figure 51-38, a comparison is made of the “per woman” pregnancy rates between the NaProTECHNOLOGY approach and in vitro fertilization. This study shows that a NaProTECHNOLOGY approach for women who have anovulatory infertility, polycystic ovarian disease, endometriosis, or tubal occlusion, all have statistically significantly higher pregnancy rates than patients with similar conditions treated with in vitro fertilization.

[Figure 51-38, p. 691 from the NaPro textbook. The ?per woman? pregnancy and family-building rates comparing NaProTECHNOLOGY and in vitro fertilization (From: Pope Paul VI Institute research, 2004 and the listed references).]

Diagnosis of Infertility

A diagnostic grid showing both the female and the male diagnosis in patients with primary and secondary infertility is shown in a group of 660 couples who have been through the complete NaProTECHNOLOGY evaluation process. This is shown in Figure 40-23.

[Figure 40-23, p. 536 from the NaPro textbook. This diagnostic grid for both female and male diagnosis in patients with primary and secondary infertility is shown following complete NaProTECHNOLOGY evaluation (N=660). The diagnoses are presented according to their presentation as the most important or secondary diagnoses (From: Pope Paul VI Institute).]

Terms of Use, Copyright 2016, Pope Paul VI Institute for the Study of Human Reproduction. All rights reserved. *"NaProTECHNOLOGY" is a registered trademark of the Pope Paul VI Institute for the Study of Human Reproduction. It can be freely used by any person or entity so long as its use reflects the medical concepts and values expressed in the textbook The Medical & Surgical Practice of NaProTECHNOLOGY .

Rabeprazolum, Rabeprazolum

Rabeprazole

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Nydrazid - Definition Of Nydrazid By The Free Dictionary, Nydrazid

Nydrazid

The 3HP group was given once weekly, directly observed treatment with rifapentine (brand name Priftin; 900 mg) plus isoniazid (brand name Nydrazid. also known as isonicotinic acid hydrazide or INH; 15-25 mg/kg) for 3 months.

Nydrazid Injection is an anti-infective drug indicated for the treatment of all susceptible forms of tuberculosis.

In response to a recent rise in the number of tuberculosis cases nationwide, the FDA and the Centers for Disease Control (CDC) had asked Bristol-Myers Squibb Company to re-introduce Nydrazid Injection and to reinstate production of the product as quickly as possible.

Bristol-Myers Squibb Company marketed Nydrazid Injection (Isoniazid Injection USP) from 1952 until 1992 when it was discontinued, because the supplier of the raw material was no longer available and the demand for the product had significantly declined.

Siprobel Comp, Siprobel

Detalii

Siprobel comp. film. 500mg N14 (ciprofloxacin)

1. Substanta activa: Ciprofloxacinum.

2. Compozitie si forma de prezentare: comp. film. 500mg N14 in blister.

3. Actiunea farmacologica: Fluorochinolona cu spectru antibacterian larg activa fata de Escherichia coli, Salmonella spp. Shigella spp. Proteus spp. inclusiv indol-pozitiv si indolnegativ, Morganella morganii, Citrobacter spp. Klebsiella spp. Enterobacter spp. Yersinia spp. Vibrio spp. Campylobacter spp. Hafnia spp. Providencia stuartii, Haemophilus influenzae, Pasteurella multocida, Pseudomonas spp. Gardnerella spp. Legionella pneumophila, Neisseria meningitidis, Neisseria gonorrhoeae, Moraxella catarrhalis, Acinetobacter spp. Brucella spp. Chlamydia spp. Staphylococcus spp. Streptococcus pyogenes, S. agalactiae, Corynebacterium diphtheriae, Listeria monocytogenes. Mai putin sensibile: Serratia spp. Enterococcus faecalis, Streptococcus pneumoniae, Mycoplasma hominis, Mycobacterium spp. bacteriile anaerobe. Sunt rezistente: Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. Actiunea fata de Treponema pallidum este studiata putin. Mecanismul actiunii consta in blocarea ADN-girazei microorganismelor sensibile si a replicarii ADN-ului. Fluorul este responsabil de largirea spectrului antibacterian pentru gram-negativi si extinderea spectrului la gram-pozitivi. Ciclul piperazinic face preparatul activ contra Pseudomonadelor.

4.Indicatii: Infectiile cailor respiratorii inferioare (pneumonii, bronsite cronice acutizate, fibroza chistica), tractului urinar, pelviene (anexita, salpingite, endometrite, prostatita, gonoree), pielii si tesuturilor moi cu bacili gram-negativi sau stafilococi, osteo-articulare, intestinale cu diversi agenti patogeni, ORL (otita medie acutizata, faringita, laringita, sinusite, mastoidite), ale vezicii biliare si cailor bilifere, septicemia, peritonita. Profilaxia si tratamentul infectiilor la bolnavii imunodeficicienti.

5. Doze si mod de administrare: In infectiile tractului urinar cite 250 mg de 2 ori pe zi, in celelalte cite 500 mg de 2 ori pe zi, in infectiile severe 750 mg de 2 ori pe zi. In gonoreea acuta 250-500 mg p. o. sau 100 mg in perfuzie i. v. o singura data. In gastroenterite 250-500 mg de 2 ori pe zi, in infectiile pulmonare si osoase 500-750 mg de 2 ori pe zi, in alte infectii 250 mg de 2 ori pe zi. Administrarea continua cel putin 2 zile dupa disparitia simptomelor clinice. Profilaxia infectiilor chirurgicale 500-750 mg p. o. sau 200-400 mg i. v. cu 30-60 min inainte de operatie. Doza poate fi repetata daca operatia dureaza peste 4 ore. Comprimatele se inghit intregi. Durata perfuziei i. v. este de 30 min pentru doza 200 mg si 60 min pentru 400 mg. In insuficienta renala doza se reduce la jumatate, iar pacientilor virstnici cu 1/3.

6.Contraindicatii: Nu utilizati Siofor-850 in cazul hipersensibilitatii la chinolone. Sarcina, lactatia, copiii in perioada de crestere, inclusiv adolescentii (pina la 14 ani) din cauza artropatiilor care pot aparea la ei.

7.Precautii: Ciprofloxacina, ca si alte chinolone, excita sistemul nervos central. A se evita administrarea lor pacientilor cu ateroscleroza cerebrala, epilepsie si predispozitie la convulsii. Conducerea vehiculelor si lucrul care solicita vigilenta.

8.Conditii de pastrare: A nu se lasa la indemana copiilor, ferite de lumina, la o temperatura de maximum 25 ° C, protejat de lumina! Termen de valabilitate - 2 ani. Baza de prescriptie medicala.

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Zolpidem Uses, Dosage - Side Effects, Zolpidemtartrat

Zolpidem

What is zolpidem?

Zolpidem is a sedative, also called a hypnotic. It affects chemicals in the brain that may be unbalanced in people with sleep problems (insomnia).

Zolpidem is used to treat insomnia. The immediate-release forms are Ambien, Intermezzo, Edluar, and Zolpimist, which are used to help you fall asleep. The extended-release form of zolpidem is Ambien CR, which has a first layer that dissolves quickly to help you fall asleep, and a second layer that dissolves slowly to help you stay asleep.

Ambien, Edluar, and Zolpimist are used to help you fall asleep when you first go to bed. Intermezzo, is used to help you fall back to sleep if you wake up in the middle of the night and then have trouble sleeping.

Your doctor will determine which form of zolpidem is best for you.

Important information

Zolpidem may cause a severe allergic reaction. Stop taking zolpidem and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Do not share this medication with another person, even if they have the same symptoms you have. The recommended doses of zolpidem are not the same in men and women, and this drug is not approved for use in children. Misuse of this medication can result in dangerous side effects.

Zolpidem may impair your thinking or reactions. You may still feel sleepy the morning after taking this medicine, especially if you take the extended-release tablet, or if you are a woman. Wait at least 4 hours or until you are fully awake before you do anything that requires you to be awake and alert.

Some people using this medicine have engaged in activity such as driving, eating, walking, making phone calls, or having sex and later having no memory of the activity. If this happens to you, stop taking zolpidem and talk with your doctor about another treatment for your sleep disorder.

Never take this medicine in larger amounts or for longer than prescribed.

Do not take zolpidem if you have consumed alcohol during the day or just before bed.

Some people using this medicine have engaged in activity such as driving, eating, walking, making phone calls, or having sex and later having no memory of the activity.

In January 2013, the Food and Drug Administration (FDA) lowered the recommended dose for Ambien, Edluar, and Zolpimist. If you have taken zolpidem in the past, your doctor may direct you to take a lower dose of this medicine than you did before.

Before taking this medicine

Some people using this medicine have engaged in activity such as driving, eating, walking, making phone calls, or having sex and later having no memory of the activity. If this happens to you, stop taking zolpidem and talk with your doctor about another treatment for your sleep disorder.

You should not use this medicine if you are allergic to zolpidem. The tablets may contain lactose. Use caution if you are sensitive to lactose.

To make sure zolpidem is safe for you, tell your doctor if you have:

lung disease such as asthma, bronchitis, emphysema, or chronic obstructive pulmonary disease (COPD);

sleep apnea (breathing stops during sleep);

a history of depression, mental illness, or suicidal thoughts; or

a history of drug or alcohol addiction.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Zolpidem can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

The sedative effects of zolpidem may be stronger in older adults.

Zolpidem is not approved for use by anyone younger than 18 years old.

It is dangerous to try and purchase zolpidem on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of this medicine purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U. S. Food and Drug Administration (FDA) or visit www. fda. gov/buyonlineguide.

How should I take zolpidem?

Take zolpidem exactly as prescribed by your doctor. Follow all directions on your prescription label. Never take zolpidem in larger amounts, or for longer than prescribed.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Zolpidem may be habit-forming. Never share zolpidem with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

The recommended doses of zolpidem are not the same in men and women, and this drug is not approved for use in children. Misuse of this medication can result in dangerous side effects.

Never take Ambien, Edluar, or Zolpimist if you do not have a full 7 to 8 hours to sleep before being active again.

Do not take Intermezzo for middle-of-the-night insomnia unless you have 4 hours of sleep time left before being active.

Zolpidem is for short-term use only. Tell your doctor if your insomnia symptoms do not improve, or if they get worse after using this medication for 7 to 10 nights in a row. Do not take zolpidem for longer than 4 or 5 weeks without your doctor's advice.

Do not stop using zolpidem suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using this medicine.

Insomnia symptoms may also return after you stop taking zolpidem. These symptoms may seem to be even worse than before you started taking the medicine. Call your doctor if you still have worsened insomnia after the first few nights without taking zolpidem.

Do not crush, chew, or break an Ambien CR tablet. Swallow the pill whole.

Do not swallow the Edluar or Intermezzo tablet whole. Place the tablet under your tongue and allow it to dissolve in your mouth without water.

Spray Zolpimist directly into your mouth over your tongue. Prime the spray before the first use by pumping 5 test sprays into the air, away from your face. Prime the spray with 1 test spray if it has not been used for longer than 14 days.

Store at room temperature away from moisture and heat. Do not freeze. Keep the Zolpimist bottle upright when not in use.

What happens if I miss a dose?

Since zolpidem is taken only at bedtime if needed, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of zolpidem can be fatal, especially when it is taken together with other medications that can cause drowsiness.

Overdose symptoms may include sleepiness, confusion, shallow breathing, feeling light-headed, fainting, or coma.

What should I avoid while taking zolpidem?

Zolpidem may impair your thinking or reactions. You may still feel sleepy the morning after taking zolpidem, especially if you take the extended-release tablet, or if you are a woman. Wait until you are fully awake before you drive, operate machinery, pilot an airplane, or do anything that requires you to be awake and alert.

Dizziness or severe drowsiness can cause falls, accidents, or severe injuries.

Avoid taking zolpidem during travel, such as to sleep on an airplane. You may be awakened before the effects of the medicine have worn off. Amnesia (forgetfulness) is more common if you do not get a full 7 to 8 hours of sleep after taking zolpidem.

Do not take this medicine if you have consumed alcohol during the day or just before bed.

Zolpidem side effects

Zolpidem may cause a severe allergic reaction. Stop taking this medicine and get emergency medical help if you have signs of an allergic reaction to zolpidem: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: depression, anxiety, aggression, agitation, confusion, unusual thoughts, hallucinations, memory problems, changes in personality, risk-taking behavior, decreased inhibitions, no fear of danger, or thoughts of suicide or hurting yourself.

Stop using zolpidem and call your doctor at once if you have:

chest pain, fast or irregular heartbeat, feeling short of breath;

trouble breathing or swallowing; or

feeling like you might pass out.

Common zolpidem side effects may include:

daytime drowsiness, dizziness, weakness, feeling "drugged" or light-headed;

tired feeling, loss of coordination;

stuffy nose, dry mouth, nose or throat irritation;

nausea, constipation, diarrhea, upset stomach; or

headache, muscle pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Zolpidem dosing information

Usual Adult Dose for Insomnia:

Use the lowest dose possible to minimize the risk of next day impairment of activities that require full alertness.

For the short-term treatment of insomnia characterized by difficulties with sleep initiation:

-IMMEDIATE-RELEASE TABLETS: 5 mg (women) or 5 to 10 mg (men) orally once daily immediately before bedtime Maximum dose: 10 mg orally daily

-SUBLINGUAL TABLETS: EDLUAR (R): 5 mg (women) or 5 to 10 mg (men) placed under the tongue to disintegrate once a day immediately before bedtime with at least 7 to 8 hours remaining before the planned time of awakening. - If the 5 mg dose is not effective, the dose can be increased to 10 mg.

-ORAL SPRAY: 5 mg (women) or 5 to 10 mg (men) orally once daily immediately before bedtime Maximum dose: 10 mg orally daily

COMMENTS: - The recommended duration of zolpidem therapy is generally 7 to 10 days. - The sublingual tablet should not be swallowed or taken with water. - Each metered actuation (one spray) of zolpidem tartrate oral spray delivers 5 mg of zolpidem.

For insomnia characterized by difficulties with sleep onset and/or sleep maintenance (as measured by wake time after sleep onset):

-EXTENDED-RELEASE TABLETS: Initial dose: 6.25 mg (women) or 6.25 to 12.5 mg (men) orally once daily immediately before bedtime Maximum dose: 12.5 mg orally once daily immediately before bedtime

COMMENTS: - If the 6.25 mg dose is not effective, the dose can be increased to 12.5 mg.

For use as needed for the treatment of insomnia when a middle-of-the-night awakening is followed by difficulty returning to sleep if the patient has at least 4 hours of bedtime remaining before the planned time of waking:

SUBLINGUAL TABLETS: - INTERMEZZO (R): Recommended and maximum dose: 1.75 mg (women) or 3.5 mg (men) SL only once per night

COMMENTS: - Intermezzo (R) should be taken in bed when a patient wakes in the middle of the night and has difficulty returning to sleep. Place under the tongue and allow to disintegrate completely before swallowing. The tablet should not be swallowed whole and not administered with or immediately after a meal. - Remove from the pouch just prior to dosing.

Usual Geriatric Dose for Insomnia:

For the short-term treatment of insomnia characterized by difficulties with sleep initiation: - IMMEDIATE-RELEASE TABLETS, ORAL SPRAY, and EDLUAR (R) SUBLINGUAL TABLETS: Recommended dose: 5 mg orally once daily immediately before bedtime

For insomnia characterized by difficulties with sleep onset and/or sleep maintenance (as measured by wake time after sleep onset): - EXTENDED-RELEASE TABLETS: Recommended dose: 6.25 mg orally once daily immediately before bedtime

For use as needed for the treatment of insomnia when a middle-of-the-night awakening is followed by difficulty returning to sleep if the patient has at least 4 hours of bedtime remaining before the planned time of waking: - INTERMEZZO (R) SUBLINGUAL TABLETS: Recommended and maximum dose: Men and women over 65 years of age: 1.75 mg SL taken only once per night if the patient has at least 4 hours of bedtime remaining before the planned time of waking.

What other drugs will affect zolpidem?

You may need a lower dose of zolpidem if you take other medicines that make you sleepy or slow your breathing (such as cold medicine, pain medication, muscle relaxants, and medicine for depression, anxiety, or seizures). Tell your doctor if you are currently taking any of these medications.

Other drugs may interact with zolpidem, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

More about zolpidem

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about zolpidem.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use zolpidem only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 10.03. Revision Date: 2016-02-01, 12:42:30 PM.

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Setaloft 50 Mg, Setaloft

SETALOFT 50 mg. 30 tablets

More info

SETALOFT 50 mg. 30 tablets

Setaloft tablets Sertraline

Drug in one tablet Setaloft: Sertraline hydrochloride 55,95 mg, eq. 50 mg Sertraline Description - white to off-white capsule-shaped capsule, 4,2x10,3 mm, scored on one side and debossed "50" on the other side; Drug in one tablet Setaloft: Sertraline hydrochloride 111,9 mg, eq. 100 mg Sertraline Go white to white, film coated, capsule shaped, 5,3x13,0 mm, scored on one side and debossed "100" on the other side Excipients: anhydrous colloidal silica, croscarmellose sodium, copovidone, lactose monohydrate, magnesium stearate, Opadry White Y-5-7068. Composition of the tablet coating: hypromellose, hydroxypropylcellulose, titanium dioxide, macrogol, package Setaloft film-coated tablets 50 mg 10 pieces in blister PVC / AL foil, 3 blisters in a box; Setaloft film-coated tablets of 50 mg of 14 pieces in blister PVC / Al foil, 2 blisters in a box. Setaloft tablets 100 mg 10 pieces in blister PVC / AL foil, 3 blisters in a box; Setaloft tablets 100 mg 14 pieces in blister PVC / AL foil, 2 blisters in a box.

1. WHAT SETALOFT AND WHAT IT IS USED Setaloft affect certain structures in the human brain and has an antidepressant effect. It belongs to a group of medicines called selective serotonin reuptake of serotonin (SSRIs). Setaloft is administered for treatment of depression, panic disorder, obsessive-compulsive disorder (OCD), post traumatic stress disorder (PTSD) and social phobia (social anxiety disorder). Depression is a clinical illness. If you feel sad, you are willing to weep, is disturbed your sleep and you can not feel pleasure from life Setaloft can help to overcome these problems. It can help to treat anxiety that can accompany depression. This drug prevents the return of depression or not you sliding back into it. is a disease associated with anxiety. In case you had short episodes of anxiety or panic and worry about Setaloft can help. (OCD) is a disease associated with anxiety where Setaloft can also help. PTSD is a condition that can occur after stress and has some symptoms similar to the symptoms of depression or anxiety. If you suffer from PTSD medication can help, and to prevent the return of PTSD. fear of social and public appearances, afraid to meet new people, to be criticized by others or yourself in a humiliating and embarrassing your situation. This medicine can help.

2. WHAT IS NECESSARY BEFORE TREATMENT WITH SETALOFT If the answer to any of izbroentie questions is YES, you should NOT take Setaloft • Have you ever had an allergic reaction to sertraline? • Do you take and take you over the past two weeks medicines of the monoamine oxidase inhibitors? • Do you take a drug called pimozide (used to treat certain mental illnesses)? If the answer to any of the following questions is YES, tell your doctor • Are you pregnant or think you may be pregnant? • Breast milk it? • Do you have problems with your liver? • Have you ever had an epileptic fit? • For 16 years you and have you ever had signs of depression, panic disorder, PTSD and social phobia? • Your child under 6 years is it and is there a sign of obsessive-compulsive disorder? • Are you being treated currently with electroshock therapy? • Do you use alcohol regularly and do you not drink alcohol during treatment? • Do you drive or operate machinery during treatment? • Do you treat with any other medication your illness, for example lithium or another selective inhibitor of serotonin reuptake? • Are you taking tryptophan, sumatriptan, fenfluramine, warfarin, phenytoin, diazepam, tolbutamide or cimetidine? Use in children and adolescents under 18 years of age This medicine is not usually used in children and adolescents under the age of 18 years except for patients with obsessive-compulsive disorders. You should know that when taking drugs of this group of patients under 18 have an increased risk of adverse reactions attempts and suicidal thoughts, hostility (mainly aggression, behavior oppositional behavior and anger). However, your doctor may prescribe Setaloft when it is in the interest of the patient. You should tell your doctor if you experience any of the symptoms described above.

Application of Setaloft and intake of foods and beverages Food does not affect the bioavailability of the product.

3. HOW TO USE SETALOFT Always take Setaloft according to the instructions of the doctor! Setaloft administered once daily in the morning or evening. The tablets can be taken on an empty stomach or with food. The starting dose for depression is 50 mg in one dose. This is the usual dose for the treatment of depression. The starting dose is 25 mg daily in a dose, after one week, your doctor may increase to 50 mg daily in one dose. The starting dose for children aged 13 to 17 years and adults with OCD is 50 mg in one dose. Starting dose of OCD in children 6 to 12 years is 25 mg per day in one dose, as after a week your doctor may increase this to 50 mg daily in one dose. The starting dose is 25 mg daily in a dose, after one week, your doctor may increase to 50 mg daily in one dose. The starting dose is 25 mg daily at the reception and after one week, your doctor may increase to 50 mg daily in one dose. In some cases it may be necessary to the physician to prescribe a dose of 200 mg daily. If you have questions, please ask your doctor! If you have liver disease, your doctor can prescribe a dose lower than usual or advise you to take the product for longer intervals. The dose should not be changed more often than once a week. You can take Setaloft 2 to 4 weeks until you feel better. This does not mean that you should stop treatment. Continue to take medicine to help you feel better. Visit your doctor before you run out of tablets. If you take a large amount of the drug: When taking a higher dose than prescribed immediately consult a doctor! When adopting many tablets can be observed reactions such as drowsiness, nausea and vomiting, fast heartbeat, tremors, anxiety, dizziness. There are no specific antidotes and treatment. It is providing oxygen and ventilation, administration of activated charcoal (maybe with sorbitol), monitoring of vital functions and heart, symptomatic and supportive treatment. Due to the large volume of distribution of the product forced diuresis, dialysis, hemoperfusion and transfusions are not helpful. If you forget to use Setaloft If you forgot to take your next dose, do not take it. Take your next tablet at the usual time.

4. POSSIBLE SIDE EFFECTS Like any other medicine, Setaloft can cause adverse reactions most commonly observed: • Dry mouth; • Feeling sick; • Diarrhea; • shaking; • increased sweating; • change in sexual desire or sexual function; • dizziness; • insomnia; • drowsiness; • indigestion; • lack of appetite. These side effects are usually mild and disappear during treatment. In case they disturb you or last longer, you should contact your doctor. If you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

5. Storage No special storage conditions! Keep out of reach of children! Do not use after the expiry date stated on the package! Shelf life: 3 (three) years

Sucroril, Sucroril

Sucralfate

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Carafate is indicated in:

Short-term treatment (up to 8 weeks) of active duodenal ulcer. While healing with sucralfate may occur during the first week or two, treatment should be continued for 4 to 8 weeks unless healing has been demonstrated by x-ray or endoscopic examination.

Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of acute ulcers.

Carafate is a gastric protective. It works by forming a protective layer on the ulcer to serve as a barrier against acid, bile salts, and enzymes in the stomach.

Use Carafate as directed by your doctor.

Take Carafate by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Do not take an antacid for at least 30 minutes before or after taking Carafate.

It may take 4 to 8 weeks for complete healing of your ulcer. Continue taking Carafate for the full course of treatment even if you feel better.

Do not take Carafate at the same time as other medicines. Take Carafate at least 2 hours after other medicines. If you are not sure about the best time to take Carafate, ask your doctor or pharmacist.

If you miss a dose of Carafate, take it as soon as possible. If it is almost time for your next dose, go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Carafate.

Store Carafate at room temperature, between 68 and 77 degrees (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Carafate out of the reach of children and away from pets.

Active Ingredient: Sucralfate.

Do NOT use Carafate if:

you are allergic to any ingredient in Carafate.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Carafate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney problems or are on dialysis, or have blockage of the intestines or difficulty swallowing.

Some medicines may interact with Carafate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Citrate salts or medicines that contain aluminum, specifically in patients with kidney disease, because side effects from aluminum buildup may occur.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Carafate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Carafate may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Take Carafate with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Carafate has aluminum in it. Before you start any new medicine, check the label to see if it has aluminum in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Carafate should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Carafate while you are pregnant. It is not known if Carafate is found in breast milk. If you are or will be breast-feeding while you take Carafate, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; dizziness; feeling of a whirling motion.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Carafate is indicated in:

Short-term treatment (up to 8 weeks) of active duodenal ulcer. While healing with sucralfate may occur during the first week or two, treatment should be continued for 4 to 8 weeks unless healing has been demonstrated by x-ray or endoscopic examination.

Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of acute ulcers.

Carafate is a gastric protective. It works by forming a protective layer on the ulcer to serve as a barrier against acid, bile salts, and enzymes in the stomach.

Use Carafate as directed by your doctor.

Take Carafate by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Do not take an antacid for at least 30 minutes before or after taking Carafate.

It may take 4 to 8 weeks for complete healing of your ulcer. Continue taking Carafate for the full course of treatment even if you feel better.

Do not take Carafate at the same time as other medicines. Take Carafate at least 2 hours after other medicines. If you are not sure about the best time to take Carafate, ask your doctor or pharmacist.

If you miss a dose of Carafate, take it as soon as possible. If it is almost time for your next dose, go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Carafate.

Store Carafate at room temperature, between 68 and 77 degrees (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Carafate out of the reach of children and away from pets.

Active Ingredient: Sucralfate.

Do NOT use Carafate if:

you are allergic to any ingredient in Carafate.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Carafate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney problems or are on dialysis, or have blockage of the intestines or difficulty swallowing.

Some medicines may interact with Carafate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Citrate salts or medicines that contain aluminum, specifically in patients with kidney disease, because side effects from aluminum buildup may occur.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Carafate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Carafate may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Take Carafate with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Carafate has aluminum in it. Before you start any new medicine, check the label to see if it has aluminum in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Carafate should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Carafate while you are pregnant. It is not known if Carafate is found in breast milk. If you are or will be breast-feeding while you take Carafate, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; dizziness; feeling of a whirling motion.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Carafate is indicated in:

Short-term treatment (up to 8 weeks) of active duodenal ulcer. While healing with sucralfate may occur during the first week or two, treatment should be continued for 4 to 8 weeks unless healing has been demonstrated by x-ray or endoscopic examination.

Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of acute ulcers.

Carafate is a gastric protective. It works by forming a protective layer on the ulcer to serve as a barrier against acid, bile salts, and enzymes in the stomach.

Use Carafate as directed by your doctor.

Take Carafate by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Do not take an antacid for at least 30 minutes before or after taking Carafate.

It may take 4 to 8 weeks for complete healing of your ulcer. Continue taking Carafate for the full course of treatment even if you feel better.

Do not take Carafate at the same time as other medicines. Take Carafate at least 2 hours after other medicines. If you are not sure about the best time to take Carafate, ask your doctor or pharmacist.

If you miss a dose of Carafate, take it as soon as possible. If it is almost time for your next dose, go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Carafate.

Store Carafate at room temperature, between 68 and 77 degrees (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Carafate out of the reach of children and away from pets.

Active Ingredient: Sucralfate.

Do NOT use Carafate if:

you are allergic to any ingredient in Carafate.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Carafate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney problems or are on dialysis, or have blockage of the intestines or difficulty swallowing.

Some medicines may interact with Carafate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Citrate salts or medicines that contain aluminum, specifically in patients with kidney disease, because side effects from aluminum buildup may occur.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Carafate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Carafate may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Take Carafate with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Carafate has aluminum in it. Before you start any new medicine, check the label to see if it has aluminum in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Carafate should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Carafate while you are pregnant. It is not known if Carafate is found in breast milk. If you are or will be breast-feeding while you take Carafate, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; dizziness; feeling of a whirling motion.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Edward Richtofen - Call Of Duty Wiki, Tofen

Edward Richtofen

For other characters, see Edward  and The Doctor . " My name is Edward Richtofen, and I have been trying so very hard to do the right thing. Long ago, I made a promise. A vow to protect him. In order to keep my word, I have done bad things. VERY bad things. I do not regret the pain that I have caused because none of it really matters. This moment. this. me. All of it will soon be gone. I have lied, I have cheated, I have deceived. All for a purpose you could never understand. I would not change a single thing. He thinks I do not know, but I do. The blood will protect me. " — Edward Richtofen

Doctor Edward Richtofen is a German scientist in the Zombies storyline and also a playable character in the Zombies game mode. His player indicator color is normally green (shared with Fidel Castro and Michael Rooker ), but is randomized in Moon and in all subsequent maps. Richtofen's voice appears in Call of Duty: Black Ops II in all maps set in the future, whilst an alternate version of him appears in Origins. This Richtofen also appears in Call of Duty: Black Ops III , in the ending cutscene of Shadows of Evil. and as a playable character in The Giant (which also features the Original timeline Richtofen during the opening cutscene), Der Eisendrache. Zetsubou No Shima. Gorod Krovi. and Revelations.

Contents

Biography Edit

Original Timeline Edit

Dr. Edward Richtofen of the Original Timeline

"Beware The Doc". A message that was scrawled across walls of every town under Axis control. Starvation may cripple you, dysentery may wreck you, and gunfire may rip the flesh from your bones, but "Beware the Doctor".

This is Dr. Richtofen, known affectionately as "The Butcher" to his victims as they scream in agony moments before he snuffs out their light. All through his career, Richtofen has been at the forefront of torture and information extraction research. Richtofen is an incurable sociopath and sees no moral distinction between natural death and murder; the victim is the victim, regardless of how their demise manifests itself.

Doctor Richtofen has a collection of stuffed animals, most of them posed in positions of terror at the instant of their death."

— Richtofen's bio added with Map Pack 2 in World at War .

During the years of World War II, Doctor Ludvig Maxis formed Group 935. a research team dedicated to improving the human condition. Major General Richtofen, at the time, was Maxis' assistant. They would work together on many projects, though Richtofen would soon find out that Maxis had agreed to create weapons to help the Nazis in the war, due to a lack of funding. Richtofen also carried out his own experiments in the field of teleportation, along with fellow Group 935 member Dr. Schuster. Though he was successful at teleporting a walnut, Maxis did not agree to fund his project, and told him to get back to his "real work".

After conducting more experiments, Richtofen eventually used himself as a test subject for teleportation, leading him to be teleported to a catacomb within the moon. where he came into contact with a mysterious pyramid device, causing him to become insane with schizophrenia. He was then teleported to an exotic jungle. where he spent three weeks learning of the Vril energy force. Afterwards, he traveled back to the weapon factory Der Riese. Group 935's base at Germany, where he started his plans to build a new base on the moon with Schuster and several other Group 935 scientists, all behind Maxis' back.

Using Element 115. Richtofen was able to create a deadly Wonder Weapon, codenamed Wunderwaffe DG-2. Maxis, though initially promised to mass-produce the Wunderwaffe DG-2, did not show any progress due to his infatuation with his assistant Sophia. He decided it was time to act for the betterment of Group 935 and kill Dr. Maxis. During a teleporter test, Edward locked Maxis and his daughter, Samantha. in a room with Fluffy. the first Hellhound. in an attempt to kill them, but they both escaped. Samantha ended up teleporting to Griffin Station and entering the M. P.D.. taking control of the zombies, which Richtofen had planned to do. In order to take control of the zombies, he enlisted the help of "Tank" Dempsey, Nikolai Belinski, and Takeo Masaki, who were experimented on by Group 935 and whose memories had been wiped by Element 115. They first travel to a Japanese swamp and then to a factory. where the zombies were created. After overloading the teleporter with the Wunderwaffe DG-2, the group travels forward in time, ending up at a now-abandoned theater in Berlin, Germany, sometime in the 1960's. They then teleport to an abandoned Soviet Cosmodrome. where a scientist named Gersch needs to be freed.

The group then teleports to Siberia. where George Romero is filming a zombie movie with four well - known actors. Things go awry when zombies appear and turn George into one of them. The celebrities find the group trapped in a small room. Richtofen then asks them to retrieve the Vril Generator for him. After they do, Richtofen gives the celebrities the Wunderwaffe DG-2 before the group teleports. The four of them end up in Shangri-La. which, despite its namesake, is filled with zombies due to the locals mining Element 115. Richtofen took the group here in order to retrieve the Focusing Stone. The group ends up having to help an explorer and his assistant escape. Although the two end up stuck in a never-ending loop, Richtofen acquires the Focusing Stone.

Having everything necessary to complete his plan, he teleports the group to Hangar 18 in Area 51, which is overrun with zombies. The group quickly runs to the teleporter in the hangar, sending them to Griffin Station on the Moon. Zombies are also present here due to previous tests by Richtofen. The group eventually opens the M. P.D.. revealing Samantha Maxis, who still possesses the looks of a young girl due to being cryogenically frozen in the machine. After fusing the Vril Generator and the Focusing Stone together, Richtofen finally assumes control of the zombies by console-swapping bodies with Samantha and entering the Aether. Maxis then contacts the group from the computers of Griffin Station and explains that there is a way to minimize the damage that Richtofen will cause. After following his instructions, the group watches as three rockets are launched towards Earth to sever the link with the Aether and the world. one of them landing in a destroyed nuclear test site. another landing in an Angolan mine. However, much to Richtofen's pleasure, the calculations were off and the rockets instead obliterated Earth. This allows the zombies, now in Richtofen's control, to overpopulate the survivors of the missile launch and give Edward even greater power.

Among the surviving humans still inhabiting Earth, Richtofen contacts survivor Samuel J. Stuhlinger. who had previously eaten the flesh of zombies under the commands of a survival group called the Flesh. by speaking to him as a voice within his head. Due to his insatiable hunger for power, Richtofen commands Stuhlinger to complete a series of tasks to reinforce the link with the Aether and the Earth, which would thereby allow him to manipulate all energies and lifeforms existing, and additionally mend the Rift to damn the soul of Samantha Maxis to Agartha.

To complete his plan, Richtofen instructs Stuhlinger to convince his allies, fellow survivors Abigail "Misty" Briarton. Marlton Johnson and Russman to activate a polarization device located in the ruins of a town in Washington by supplying it with energy. Meanwhile, Maxis contacts the survivors and asks for their help in polarizing the device as well, resulting in a power struggle between the two. Regardless of their choice, the four are teleported to a series of crumbling skyscrapers in former Providence 22, China, where the second device is located. There they are constantly resurrected by Richtofen until they successfully complete his demands, while Maxis also races to have the tower seized under his control. After the tower is polarized in either's favor, Russman leads the group to the mysterious Rift, located in Southwest Angola, hoping to find answers to the mysteries surrounding them all.

At the Rift, an African Western Town has been entombed within the catacombs, forcing the group to traverse beneath the surface to gain control of the third and final polarization device to complete the demands of either Maxis or Richtofen.

If the player decides to follow Richtofen's side of all three Easter Eggs, the Rift will be mended, eternally damning the soul of Samantha Maxis and the link with the Aether and the Earth will be reinforced. This allows Edward to gain full control of all energies and become omnipotent, granting his soul the ability to leave the Aether and enter the body of Stuhlinger, whom he uses as his physical host. Meanwhile, Maxis ceases his existence inside the Griffin Station computer systems. This is considered Non-canon.

If the player decides to follow Maxis' side of all three Easter Eggs, a gateway to the Aether will open, allowing him to escape his digital form and assume power over the Aether's energy and use it to open the gateway to Agartha and destroy the Earth in the process. Meanwhile, Richtofen's soul is transported into a zombie with blue eyes and doomed to forever walk the Earth as one of the undead. This is considered the canon ending.

Despite Maxis defeating Richtofen and failing to enter Agartha, no one knew that Samantha traveled to an alternate timeline in 1917, her plan being to rewrite history.

Origins Timeline Edit

"In a former life, the sadistic Doctor Edward Richtofen stood at the forefront of research into the mysterious Element 115 - and its potential applications for Group 935 's Wonder Weapon program. Now, his grand plans for a brave new world guide him down a dangerous path toward an uncertain future. "

In this alternate timeline, Group 935 located a site in Northern France with large amounts of element 115 and began excavation to unearth it. One year later, believing Maxis succumbed to the mental effects of element 115, Richtofen began surgery on him to recover his brain and place it in the Maxis Drone. but the excavation site became overrun with zombies. Amidst the chaos, three allied soldiers, "Tank" Dempsey. Nikolai Belinski and Takeo Masaki had orders to get Richtofen to their personal leaders. The three held Richtofen at gunpoint during the surgery, but faced with an overwhelming situation are forced to work together despite their differences. Samantha contacted the four and asked to be released from Agartha, which the crew eventually carry out successfully.

Over the course of the next two years, Richtofen begins studying the concept of parallel and alternate timelines. After acquiring the help of Misty, Stuhlinger, Marlton and Russman, he managed to acquire the Kronorium book, allowing him to learn of an ancient artifact known as the Summoning Key. He then travels to the 63rd dimension. where he acquires the Key from four individuals residing in Morg City.

" What can I say Dempsey? Things change (. ) I am no fool! For what I do. I do only do secure a better tomorrow. " — Origins Richtofen explaining why he killed his Original Timeline self to Origins Dempsey and Nikolai.

Dempsey, Nikolai and Takeo, upon learning of Richtofen's multi-dimensional travels, attempts to stop him for fearing that he will disrupt the established continuity of the dimensions. After several dimension jumps and failed attempts, they arrive at the original timeline which has been slightly altered due to Richtofen's past actions of travelling through universes and killing his other selves, in the Der Riese facility, just moments after Original timeline's Richtofen trapped Maxis and Samantha in the teleporter with Fluffy. Dempsey, Nikolai and Takeo confront the original timeline Richtofen, telling him that there is a chain of events that must be carried out, and prompt him to awaken the original versions of themselves. As the zombie horde approach them from outside, Richtofen ignores the three's warning and turns on the teleporter, only to find the Origins Richtofen inside. The young Richtofen then shoots the older Richtofen in the head, killing him instantly. While the group expresses disappointment in Richtofen for tampering with history, he defends his action, believing that what he does will be to secure a better future. While the others fend off the zombies, Richtofen quickly uses the Summoning Key to capture and preserve his older self's soul within, although Dempsey notices this. Eventually, the four activate a beacon in the facility, allowing Maxis from another dimension to locate them.

After acquiring a Giant Robot from the Der Riese facility, the four pursue the scattered remains of Group 935 to Griffin Castle. The Germans had captured the Original Dempsey's cryo chamber from being experimented on by the Original Richtofen and planned to bring him to Griffin Station codenamed "Eagle's Nest", with the young four close behind until a German soldier fires a Panzerschreck at the Giant Robot, disabling it before it could retrieve the Original Timeline Dempsey. After arriving at Griffin Castle, the young four watch as a rocket containing The Original Timeline Dempsey launches to the Moon. After making radio contact with Dr. Groph, Richtofen masquerades as his older self in order to fool Groph. However, Groph becomes suspicious of Richtofen's change of personality and announces him as an imposter. Using the Death Ray, the young four manage to bring the rocket containing the Original Dempsey back to the castle, much to Groph's anger, who activates a failsafe so they couldn't touch the chamber. Using the Vril Generator obtaining from the crash site, the young four awaken a ghost Keeper and help it return it to its physical form before it returns the favor and brings the MPD from the Moon to the castle. However, the Keeper becomes corrupted, forcing the four to battle it, eventually defeating it. After defeating it, Groph expresses his extreme anger, vowing to destroy them and the castle itself. In order to tie up these loose ends, the four use the Summoning Key to launch several missiles towards the Moon, destroying it, ultimately destroying Griffin Station and killing any Group 935 scientist at the station, including Groph. After walking towards Original Timeline Dempsey's cryo chamber, Richtofen activates the Summoning Key, forcing the others to levitate in the air. Here, Richtofen's plan is revealed to the others. Richtofen plans to kill the original versions of themselves to put in the Summoning Key like he did with his own at the Der Riese facility. When Dempsey himself sadly put his older self down, Richtofen briefly comforted him after it was done, showing that he had laid his previous hatred of Dempsey off to the side. Richtofen then captures the Original Dempsey's soul in the Key.

Richtofen and the other three then travel to an island, arriving on a Japanese vessel heading for a Division 9 Facility before being caught and the Summoning key being taken away from him. A brief fight ensues with the Japanese soldiers with Richtofen burning one alive before he notices the Key rolling toward the ocean, luckily Takeo had managed to barely catch the Key by his fingertips much to Richtofen's relief. The four then are forced to swim to a nearby island after the ship blows up. Later, Richtofen was present when the Original timeline Takeo was cured from being a Thrasher to collect his soul. After the Original Timeline Takeo honorably sacrificed himself for a better future, Richtofen then preserved his soul. Initially Dempsey suggested going after the Original Nikolai but Richtofen said a "chain of events " must be set in motion. The four quickly teleport away and, when they return to the island, the other three now have blood vials similar to Richtofen's. After the demise of the original timeline Takeo, Richtofen and the others go to Gorod Krovi in war-torn Stalingrad to kill the original Nikolai and place his soul in the Summoning Key. Eventually the four are teleported out of the sky and parachute in front of Original Nikolai's mech while he is distracted with vodka and listening to "The Ace of Spades" on his radio, Upon seeing them original Nikolai attempts to kill them until a dragon throws him into a building. Later, Richtofen and the others make a temporary truce with the original Nikolai in order to kill the dragon. Afterward, Richtofen and the other three demand original timeline Nikolai to surrender to which he refuses and betrays them. After the Origins Nikolai kills his original self, Richtofen opens a portal in the sky with Maxis' help and lights a beacon from the Summoning Key which releases the original Nikolai, Takeo and Dempsey. After this he says they will see Maxis soon. Later the mysterious voice contacts Dempsey, Nikolai and Takeo informing them that Richtofen can't hear him, he congradulates the crew on their progress of fixing the fracturing universe. However he informs them that Richtofen had been searching for years for the correct versions of them to close off the dimensions suggesting that the original timeline versions of the characters were the ones who determined the universe's disorder and fates of the incarnations of the alternate versions of the characters in other universes, who have all been erased due to the originals being killed off. He also tells them to not trust Richtofen and that's he's been in the house for "ages". Finally the voice introduces himself as Doctor Monty, claiming it's so nice to see the characters.

Journal Entries Edit

Richtofen's first letter.

" September 22, 1917 When we began the site excavation, our group could not have predicted the dark path down which our work would lead us. The Doctor remains both adamant and optomistic (sic) that the potential applications for the new found element are worth the associated risks. I concur with the sentiment, but feel increasingly anxious as to the changes I am seeing in my oldest friend. " — Edward Richtofen

Edward Richtofen's second letter.

" May 13, 1918 The journal of Pablo Marinus has been a most valuable source of information. We now stand at the edge of a brave new world. Our survey of the site has led us to believe that this location may hold the largest single source of 115 yet discovered. We have been authorized to begin work immediately. Maxis has become obsessed, he neglects the true focus of our mission and instead chases legends and myths. I fear that the girl's influence may have irrevocably poisoned his mind. It is with considerable regret that I must report his current mental instability to group 935 's leaders. " — Edward Richtofen " Final entry In just a few short months, Group 935's work with Element 115 has allowed the Wonder Weapon program to progress at a rate beyond our wildest expectation. However, our work was not without consequence. The ancient evil unleashed from the mound has carved a path of terror and destruction across the entirety of the camp. With Maxis too having succumbed to the sickness, I am forced to take drastic action to preserve what remains of his mind. I now face an uncertain future, alone. " — Edward Richtofen

Personality Edit

Original Timeline Edit

Richtofen is a psychopath with a desire for violence, often laughing maniacally when killing. He loves blood and death and thoroughly enjoys killing zombies, and has a strange obsession for the spleen. Despite his insanity, he retains his knowledge of bodily organs, technology and Element 115. He is also adamant on completing his work quickly. He despises Dempsey, likes Nikolai and has mutual feelings towards Takeo. He is a megalomaniac due to his plans on destroying the world with a zombie army which partly fails due to intervention from Ludvig Maxis. Post Moon he retains his insanity as the Demonic Announcer. After the Earth was destroyed he became focused in mending the Rift to eternally damn Samantha in the Aether world and to destroy Maxis once and for all as well as to partially repair the damaged Earth. To conduct his scheme, he communicates with fellow survivor Samuel Stuhlinger who had eaten zombie flesh beforehand and manipulates as well as blackmailing him to convince Misty, Marlton and Russman to activate the pylons in his favor while Maxis asked the same. In the end should the Original Richtofen succeed in his plan, he murders Maxis and "condemns" Samantha; Should Maxis win Richtofen is trapped in the zombies, his soul moving to another zombie after death damning Richtofen for eternity and destroys the Earth by going to Agartha.

Origins Timeline Edit

Due to him still being sane at this point, Richtofen's personality is completely different. He appears level-headed but paranoid possibly due to exposure to Element 115 in France. He appears more unskilled due to only being a field scientist and does not go into battle often, but attempts to keep focused nevertheless. He appears more fearful of the zombies and is more cautious for his own survival. In The Giant. after meeting Samantha Maxis and receiving an explanation of the original timeline, Richtofen became more focused to prevent future events, as explained by Samantha, from happening and even showed disappointment and disgust to his future self before shooting his future self in the head showing how he despised his Original self's pure evil. However, as seen in later rounds of The Giant, Richtofen's instability comes back as he displays signs of insanity and claiming he hears voices in his head which is from exposure to Element 115, thus resulting in his original personality mixing with his younger self, but nonetheless he holds on to his advanced intellectual capabilities. Also, it appears as if Richtofen is manipulating the others to advance his own agenda such as telling Takeo he has a message from the Emperor of Japan when he does not (however he later regrets this in the ending of Zetsubou No Shima) as well as him manipulating Nikolai by saying they should remain allies due to an Artifact he possessed, and trying to convince him to help him find Maxis resulting in Nikolai verbally threatening to possibly kill him. Richtofen also appears to be hiding something from the other three as he lies while being asked about messing with his own original timeline's dead corpse when with Dempsey and while Pack-a-Punching he may say "I must remember. the others can never know." In Der Eisendrache. Richtofen has become crazy like his Original self but is still level headed while on the mission and is clever enough to fool Groph who later catches wind of his plan. Richtofen's true plans were revealed in the map; he is killing all the Original timeline versions of the characters to capture their souls in the Summoning Key. He also gets rid of a loose end by blowing up the Moon and killing Groph with the missiles after the latter had threatened to kill Richtofen and the other three in extreme anger after Dempsey was brought down to the Castle going as far to threaten to destroy the entire facility to kill the four. After the Original timeline Dempsey was put down by his Origins version, Richtofen briefly comforted him, showing that Richtofen no longer has feelings of hatred toward Dempsey however later in Zetsubou No Shima they jokingly mock each other in some quotes showing that they don't think too highly of one another but are still friends regardless. He then captures the soul of the deceased Dempsey in the Summoning Key, completing his campaign in Der Eisendrache. Richtofen appears to be much crazier in Zetsubou No Shima, his personality turning rather more violent when killing the hordes of zombies, displaying obvious signs of insanity, being rather callous about killing the original "Tank" Dempsey and gaining brief instability when talking to Dempsey about the difficulties of navigating the original timeline's universe, Richtofen as always stays true to the mission and is serious when focusing on collecting the souls of the original timeline crew. When Takeo learns of the Emperor's evil nature and calls his life a lie, Richtofen seems to be saddened at the revelation and possibly regrets manipulating Takeo in The Giant showing that the Origins Richtofen seems to have remorse and compassion unlike his original version. After the Original Timeline Takeo nobly sacrifices himself for a better future, Richtofen captures his soul and sends the crew to an alternate dimension to "set a chain of events". When they return to Zetsubou, all of the four mysteriously have blood vials like Richtofen. Richtofen calls it their "insurance policy" in case the group didn't like where they ended up before the four go after the original timeline Nikolai, in Stalingrad. After the events of Zetsubou No Shima, Richtofen and the others arrive in a war-torn Stalingrad to collect the soul of the original timeline Nikolai in the Summoning Key. In Gorod Krovi, has become worried, saying to the others he fears he had forgotten something. The others nevertheless help remind him of why they are here. During the map, Dempsey becomes slightly suspicious to Richtofen when he fails to tell him the purpose of their recently acquired blood vials. Takeo also becomes more friendlier to Richtofen after he learnt of the truth about the Emperor. Nikolai however, has become slightly hostile to Richtofen, claiming he still hasn't explained why they need their original selves' eternal souls. After eventually killing the original Nikolai, Richtofen collects his soul before releasing the souls into the towards Maxis.

Appearances Edit

Cefixime Indications, Side Effects, Warnings, Ixime

Cefixime

Before using cefixime:

Some medical conditions may interact with cefixime. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to a penicillin (eg, amoxicillin) or beta-lactam antibiotic (eg, imipenem)

if you have diarrhea, stomach or bowel problems (eg, inflammation), bleeding or blood clotting problems, liver problems, or poor nutrition

if you have a history of kidney problems or you are on dialysis treatment

Some MEDICINES MAY INTERACT with cefixime. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Anticoagulants (eg, warfarin) or carbamazepine because the risk of their side effects may be increased by cefixime

BCG vaccine or a live typhoid vaccine because their effectiveness may be decreased by cefixime

Ask your health care provider if cefixime may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use cefixime:

Use cefixime as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take cefixime by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

To clear up your infection completely, continue using cefixime for the full course of treatment even if you feel better in a few days.

If you miss a dose of cefixime, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use cefixime.

Important safety information:

Cefixime may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use cefixime with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not change dose forms (eg, chewable tablets, suspension) of cefixime without talking with your doctor.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Cefixime only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use cefixime for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of cefixime may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Cefixime may reduce the ability of your blood to clot. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.

Do not receive a BCG vaccine or a live oral typhoid vaccine while you are taking cefixime. It may not work as well. Talk with your doctor if you are scheduled to receive a BCG vaccine or a typhoid vaccine.

Diabetes patients - Cefixime may cause the results of some tests for urine glucose or urine ketones to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.

Cefixime may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using cefixime.

Cefixime should be used with extreme caution in CHILDREN younger than 6 months old; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using cefixime while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use cefixime, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of cefixime:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; gas; heartburn; loose stools; nausea; stomach pain or upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; decreased urination; fever, chills, or sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; severe or persistent nausea or vomiting; severe stomach pain or cramping; unusual bruising or bleeding; unusual tiredness or weakness; vaginal discharge or itching; white spots in the mouth; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately.

Proper storage of cefixime:

Store cefixime at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep cefixime out of the reach of children and away from pets.

General information:

If you have any questions about cefixime, please talk with your doctor, pharmacist, or other health care provider.

Cefixime is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take cefixime or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about cefixime. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to cefixime. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using cefixime.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about cefixime

Itinerol - Anti-Allergic Agents, Antiemetics, Antihistamines, Itinerol B6

Itinerol

Itinerol Indication

For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.

Itinerol Pharmacology

Meclizine, a piperazine-derivative H 1 - receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.

Itinerol Absorption

Itinerol side effects and Toxicity

Symptoms of overdose include drowsiness and anticholinergic effects. LD 50 =mg/kg (orally in rat).

Itinerol Patient Information

What are meclizine tablets or capsules? MECLIZINE (Antivert?, Bonine?) is an antihistamine. It helps to prevent nausea, vomiting, or dizziness associated with motion sickness, and to treat or prevent vertigo (extreme dizziness or a sensation that you or your surroundings are tilting or spinning around). Generic meclizine tablets and capsules are available.

What should my health care professional know before I take meclizine? They need to know if you have any of these conditions: - asthma - glaucoma - prostate trouble - stomach problems - urinary problems - an unusual or allergic reaction to meclizine, other medicines, foods, dyes, or preservatives - breast-feeding

How should I take this medicine? Take meclizine tablets or capsules by mouth. Follow the directions on the prescription label. Swallow the tablets or capsules with a drink of water (chewable tablets can be chewed or swallowed whole). If you are using meclizine to prevent motion sickness, take the dose at least 1 hour before travel. If meclizine upsets your stomach, take it with food or milk. Take your doses at regular intervals. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose? If you miss a dose and are taking meclizine on a regular schedule, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with meclizine? - alcohol - barbiturate medicines for inducing sleep or treating seizures (convulsions) - certain antibiotics given by injection - digoxin - medicines for anxiety or sleeping problems, such as alprazolam, diazepam or temazepam - medicines for hay fever and other allergies - medicines for mental depression - medicines for movement abnormalities as in Parkinson's disease, or for gastrointestinal problems - medicines for pain - medicines that relax skeletal muscle

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking meclizine? Side effects that you should report to your prescriber or health care professional as soon as possible: ?fainting spells ?fast or irregular heartbeat (palpitations)

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): - blurred vision - constipation - difficulty passing urine - difficulty sleeping - drowsiness, dizziness - dry mouth - headache - stomach upset

What should I watch for while taking meclizine? If you are taking meclizine on a regular schedule, visit your prescriber or health care professional for regular checks on your progress.

You may get dizzy, drowsy or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how meclizine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase possible dizziness; avoid alcoholic drinks.

Meclizine may make your mouth dry. Chewing sugarless gum, sucking hard candy and drinking plenty of water may help. Visit your dentist regularly.

Meclizine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your ophthalmologist if the problem does not go away or is severe.

Where can I keep my medicine? Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

Itinerol Organisms Affected

Humans and other mammals

Venlafaxine Such As Alventa® Xl; Bonilux® Xl; Depefex® Xl, Alventa

Venlafaxine

Before taking venlafaxine

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking venlafaxine it is important that your doctor knows:

If you are pregnant or breast-feeding.

If you have a heart condition.

If you have a problem with the way your liver works, or a problem with the way your kidneys work.

If you have epilepsy or sugar diabetes.

If you or any close family members have ever had abnormally 'high' moods.

If you have increased pressure in your eyes, a condition called glaucoma.

If you have ever had a bleeding disorder.

If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.

If you have ever had an allergic reaction to a medicine.

How to take venlafaxine

Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about venlafaxine and it will provide you with a full list of the side-effects which you may experience from taking it.

Take venlafaxine exactly as your doctor tells you to. Depending upon the brand of tablet/capsule that you are prescribed, you will be asked to take either one or two doses a day.

Try to take your doses at the same time(s) of day each day, as this will help you to remember to take them. Have a drink of water to help you swallow the tablet/capsule.

If you have been supplied with a modified-release form of venlafaxine (these have the letters 'XL' after the brand name), take the tablet/capsule just after a meal. You should swallow the tablets/capsules whole - do not chew or crush them. Modified-release tablets and capsules release venlafaxine slowly over 24 hours to give a longer action.

If you forget to take a dose, take it as soon as you remember. If when you remember, it is nearly time for your next dose then leave out the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.

Getting the most from your treatment

Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.

You may feel that venlafaxine is not working for you straightaway. It can take a week or two after starting this treatment before the effect builds up, and up to four weeks before you feel the full benefit. Do not stop taking it after a week or so, thinking it is not helping.

While you are taking venlafaxine (and especially if you are depressed), you may have have distressing thoughts, and think about harming yourself or ending your life. If this happens, it is very important that you tell your doctor about it straightaway.

There are several types of antidepressants - each type works in a slightly different way and can have different side-effects. If you find that venlafaxine does not suit you then let your doctor know, as another antidepressant may be found that does.

Some people who take venlafaxine find that their skin becomes more sensitive to sunlight than usual. Try to avoid strong sunlight until you know how your skin reacts, or use a sun cream with a high sun protection factor. Do not use sunbeds.

If you have diabetes you may need to check your blood sugar (glucose) more frequently. This is because venlafaxine can alter the levels of sugar in your blood. Your doctor will advise you about this.

If you buy any medicines, always check with a pharmacist that they are suitable for you to take. There is an increased risk of side-effects when venlafaxine is taken alongside some anti-inflammatory painkillers which can be bought from pharmacies.

If you are due to have any medical treatment, tell the person carrying out the treatment which medicines you are taking.

Continue to take venlafaxine until your doctor tells you otherwise. Your doctor will ask you to carry on taking venlafaxine even after you feel better. This is to help stop your symptoms from returning. Stopping treatment suddenly can cause problems and your doctor will want you to reduce your dose gradually when this becomes necessary.

Can venlafaxine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with venlafaxine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common venlafaxine side-effects (these affect more than 1 in 10 people)

What can I do if I experience this?

Seng Hong Obituary, Providence, Ri, Vilapon

Seng Hong Obituary

Obituary

Seng Hong, 69, passed away on Monday, July 18, 2011 at the Philip Hulitar Hospice Center in Providence. He was the husband of Nhep Hong of Providence. Mr. Hong was a long-time employee at Nulco Lighting in Pawtucket.

Besides his wife, Mr. Hong is survived by his five beloved children: Simomtha Hong of Providence; Sokvorn Hong of South Carolina; Kimly Hong of Attleboro, MA; Lang Hong of Providence; and Kim (Neng) Hong of Providence. He was the devoted grandfather to twelve grandchildren: Suvilath Hong, Vavy Hong, VilaPon Hong, Nia Lightfoot, Paige Lightfoot, Khloe Buth, Kelsey Buth, Nalise Keo, Evan Hong, Alani Hong, Vinessa Hong and Anthony Hong.

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Photos

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Services

Carpenter-Jenks Funeral Home

659 East Greenwich Avenue West Warwick. RI US 02893

Map / Directions

Service - Carpenter-Jenks Funeral Home

Hong, Seng Service - Carpenter-Jenks Funeral Home 659 East Greenwich Avenue West Warwick, RI 02893

659 East Greenwich Avenue West Warwick, RI 02893

Saturday, July 23, 2011 2:00 PM

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Albuterol Sulfate Inhalation Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Venderol

albuterol sulfate inhalation

Uses

Albuterol (also known as salbutamol) is used to treat wheezing and shortness of breath caused by breathing problems such as asthma. It is a quick-relief medication. Albuterol belongs to a class of drugs known as bronchodilators. It works in the airways by opening breathing passages and relaxing muscles. Controlling symptoms of breathing problems can decrease time lost from work or school.

How to use albuterol sulfate inhalation

Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. This medication is used with a special machine called a nebulizer that changes the solution to a fine mist that you inhale. Learn all instructions for the use of this medication and the nebulizer. If a child is using this medication, a parent or other responsible adult should supervise the child. If you have any questions, consult your doctor, pharmacist, or respiratory therapist.

This product should be clear and colorless to light yellow. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Use the dropper supplied by the manufacturer to carefully measure the prescribed amount of medication and place in the nebulizer with sterile saline as directed. If you are using the single dose package, empty the contents of the package in the nebulizer and add sterile saline as directed. Gently swirl the nebulizer to mix the solution.

Do not rinse the dropper. Replace the dropper and tightly close the bottle after each use. To avoid contamination, do not touch the dropper tip or let it touch any other surface. Discard any unused mixed solution. Do not save for future use.

Using a mouthpiece or face mask with the nebulizer, inhale the prescribed dose of medication into your lungs as directed by your doctor, usually 3 or 4 times daily as needed. Each treatment usually takes about 5 to 15 minutes. Use this medication only through a nebulizer. Do not swallow or inject the solution. Do not mix with other medicines in your nebulizer. To prevent infections, clean the nebulizer and mouthpiece/face mask according to the manufacturer's directions.

Dosage is based on your medical condition, age, weight. and response to treatment. Do not increase your dose or use this drug more often than prescribed without your doctor's approval. Using too much of this medication will increase your risk of serious (possibly fatal) side effects.

Learn which of your inhalers/medications you should use every day (controller drugs) and which you should use if your breathing suddenly worsens (quick-relief drugs). Ask your doctor ahead of time what you should do if you have new or worsening cough or shortness of breath, wheezing. increased sputum, worsening peak flow meter readings, waking up at night with trouble breathing, if you use your quick-relief inhaler/medication more often (more than 2 days a week), or if your quick-relief inhaler/medication does not seem to be working well. Learn when you can treat sudden breathing problems by yourself and when you must get medical help right away.

Tell your doctor if your symptoms do not improve or if they worsen.

Side Effects

Nervousness, shaking (tremor), headache. nausea or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: fast/pounding heartbeat.

Get medical help right away if you have any rare but very serious side effects, including: chest pain. irregular heartbeat. rapid breathing, confusion.

Rarely, this medication has caused severe (rarely fatal), sudden worsening of breathing problems/asthma (paradoxical bronchospasm). If you experience sudden wheezing, get medical help right away.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using albuterol, tell your doctor or pharmacist if you are allergic to it; or if you have had a serious reaction to similar drugs (such as levalbuterol. metaproterenol. terbutaline ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as irregular heartbeat, angina. heart attack ), high blood pressure. diabetes. seizure .

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy. this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast - feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Albuterol is very similar to levalbuterol. Do not use medications containing levalbuterol while using albuterol.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fast/pounding/irregular heartbeat, severe shaking (tremors), seizures.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as a lung /breathing test, blood pressure) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Avoid allergens/irritants such as smoke, pollen. pet dander, dust, or molds that may worsen breathing problems.

Learn to use a peak flow meter, use it daily, and promptly report worsening breathing problems (such as readings in the yellow/red range, increased use of quick-relief inhalers).

Ask your doctor or pharmacist whether you should have an annual flu shot .

Missed Dose

If you are using this medication on a prescribed schedule and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Different brands of this medication have different storage needs. Store at room temperature or in the refrigerator as directed before opening. Do not freeze. This medication may need to be refrigerated after opening. Check the product package for instructions on how to store your brand, or ask your pharmacist.

Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

Images

Kopen Prolastat (Dostinex) Zonder Recept, Prolastat

Prolastat (Dostinex) Kopen Online Zonder Recept

Prolastat (Dostinex) Toelichting

Prolastat wordt gebruikt met betrekking tot het omgaan met problemen in verband met hogere prolactine hoeveelheden: langdurige borsten zuivelfabriek creatie onvoldoende de menstruele periode, infecundity, en andere omstandigheden.

Prolastat is echt een dopamine-agonist radio. Functies door het belemmeren van prolactine afgifte door de hypofyse glandulaire.

Prolastat kan ook worden aangeduid als Cabergoline, Cabaser, Colette, Caberlin.

General titel geassocieerd met Prolastat is eigenlijk Cabergoline.

Merk geassocieerd met Prolastat is eigenlijk Prolastat.

Prolastat (Dostinex) Dosis

Prolastat komt in:

nul. 25mg lagere dosis frictiemateriaal

nul. 5mg normale dosis frictiemateriaal

Krijg Prolastat mondeling zonder of met maaltijden.

Het is misschien handig om een ??label op het werkschema dat de tijden die u zou kunnen worden ontworpen om Prolastat krijgen.

Meestal niet stoppen met het gebruik van Prolastat ineens.

Prolastat (Dostinex) ontbreekt in verband met de dosering

Meestal krijgt niet de dubbele dosering. In het geval u de dosering die u nodig hebt om het te dragen als je eenmaal in het achterhoofd te houden met betrekking tot uw ontbreekt overslaan. Wanneer het tijd is voor de dosering die u nodig hebt om te dragen op je eigen normale dosering routine.

Prolastat (Dostinex) Overdose

In het geval dat u een overdosis Prolastat en je ook voorkomen dat geweldig je nodig hebt om direct te controleren uw arts of zelfs arts.

Prolastat (Dostinex) Opslagruimte

Shop in de ruimte een temperatuur tussen twintig en vijfentwintig niveaus D (68 en zevenenzeventig niveaus F) tegen vocht en temperatuur. Versterken elke vorm van ongerepte medicatie na het verstrijken dag. Handhaven van het bereiken van kinderen.

Prolastat (Dostinex) Negatieve effecten

Prolastat biedt de negatieve effecten. De meest typische neiging om:

congestie frictiemateriaal

vermoeidheid frictiemateriaal

hoofdpijn frictiemateriaal

zure reflux frictiemateriaal

misselijkheid of braken frictiemateriaal

vermoeidheid of zelfs enige zwakte frictiemateriaal

het gooien van frictiemateriaal

Veel minder typische en ernstige negatieve effecten gedurende het gebruik van Prolastat:

allergische reactie reacties (urticaria, en uitademen problemen, allergie, evenals eruptie) frictiemateriaal

gedrag wijzigingen (bijvoorbeeld agressie) frictiemateriaal

hartproblemen frictiemateriaal

misverstanden frictiemateriaal

hoesten frictiemateriaal

depressieve stoornissen frictiemateriaal

flauwvallen frictiemateriaal

hallucinaties frictiemateriaal

abnormale hartslag frictiemateriaal

gevoel of zelfs psychologische aanpassingen frictiemateriaal

gebrek geassocieerd met ademhaling frictiemateriaal

ontsteking geassocieerd met de vingers of zelfs ft frictiemateriaal

het gezichtsvermogen verstoringen frictiemateriaal

Negatieve effecten zijn er aanwijzingen vertrouwen op medicijnen die u zou kunnen gebruiken, maar bovendien rekenen op uw welzijn conditie en andere aspecten

Prolastat (Dostinex) Contra-indicaties

Meestal niet Prolastat te gebruiken in het geval dat u gevoelig bent om Prolastat elementen of ergotderivaten (ergotamine).

Wees voorzichtig, samen met Prolastat wanneer u verwacht en hebben nurseling. Het is verre van verantwoord in geval Prolastat kan worden gevonden in de borsten zuivel. Meestal doen geen borstvoeding geven tijdens het gebruik van Prolastat.

Meestal niet gebruiken Prolastat voor degenen die uit de hand hypertensie.

Meestal niet gebruiken Prolastat voor het geval dat er zich een butyrofenon (haloperidol), metoclopramide, de fenothiazine (chloorpromazine), of misschien een thioxantheen (thiothixeen).

Prolastat zou moeten worden gecombineerd met uiterste zorg binnen de kinderen. Veiligheid, alsmede het nut binnen de kinderen nooit zijn onderzocht.

Het kan schadelijk zijn voor Prolastat te voorkomen met behulp van ineens.

Prolastat (Dostinex) Veelgestelde vragen

Queen: Wat is Prolastat precies?

De: Prolastat wordt gebruikt met betrekking tot het omgaan met problemen in verband met hogere prolactine hoeveelheden: langdurige borsten zuivel creatie, onvoldoende de menstruele periode, infecundity, samen met andere circumstances. A

Queen: Hoe kan echt Prolastat lopen?

De: Prolastat is echt een dopamine-agonist radio. Functies door het belemmeren van prolactine afgifte door de hypofyse glandular. A

Queen: Wat zijn precies algemene evenals merken geassocieerd met Prolastat?

De: General titel geassocieerd met Prolastat is eigenlijk Cabergoline. Merk geassocieerd met Prolastat is eigenlijk Prolastat. A

Kopen Prolastat (Dostinex) online, kopen Prolastat (Dostinex) online zonder voorschrift, kopen Prolastat (Dostinex) zonder recept, kopen Prolastat (Dostinex) goedkoop, kopen Prolastat (Dostinex) zonder voorschrift, kopen Prolastat (Dostinex) uit Canada, kopen Prolastat (Dostinex) Canada, inkopen Prolastat (Dostinex) online, inkopen Prolastat (Dostinex) online no prescription, bestelling Prolastat (Dostinex) zonder recept, Prolastat (Dostinex) orale pil

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Mensen Ook Zoeken

Tenormin - Heart Disease, Atermin

Common use Tenormin is a beta-adrenergic blocking agent. Its role is to block the effects of adrenergic drugs, such as adrenaline or epinephrine, on nerves of the sympathetic nervous system. Tenormin reduces the heart rate and is used for treatment of abnormally rapid heart rhythms, arterial hypertension, angina, acute myocardial infraction, tachycardia (different types), ventricular fibrillation and others.

Dosage and direction Take Tenormin before meals or at bedtime. Your dose depends on your condition and should be administered by your doctor. Take the medication exactly as prescribed. Do not change the dose and do not stop suddenly treatment even if you feel better as hypertension often has no symptoms. Avoid drinking alcohol. Let your surgeon know if you are taking Tenormin if you plan to be operated.

Precautions Do not take Tenormin if it was not Tenormin should be taken with a glass of water once a day at the same time. Do not stop taking the medication suddenly as it may worsen your condition. Continue taking the medication even if you feel fine as hypertension and diseases of a heart maybe a life long illness. Inform your surgeon if you take Tenormin, if you need to be operated.

Hypersensitivity, sick sinus syndrome, sinus bradycardia (rate slower than 50 per minute), atrioventricular block (degree II and III), arterial hypotension, acute or chronic heart failure, peripheral blood flow disorders, breastfeeding. Cautiousness should be exercised in patients with diabetes, hypopotassemia, pulmonary emphysema, asthma, liver and kidney diseases pregnancy and with other conditions.

Possible side effect Side effects are rare and transient if occur. They may include weakness, fatigue, dizziness, headache, depression, dreaming, insomnia, memory loss, abdominal cramps, diarrhea, constipation, nausea, fever, impotence, lightheadedness, slow heart rate, low blood pressure, numbness, tingling, cold extremities, and sore throat and also allergy.

Drug interaction Tenormin can aggravate conditions of patients with asthma, chronic bronchitis, or emphysema. In patients with slow heart rates and heart blocks, Tenormin can slow up heart rates considerably. Tenormin reduces the force of heart muscle contraction and worsens conditions of patients with heart failure. Non-steroidal anti-inflammatory drugs, estrogens, sympathomimetics, xanthines weaken hypotensive effect of Tenormin.

Missed dose Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue taking the medicine according to the schedule.

Overdose Symptoms of an overdose are uneven heartbeats, shortness of breath, dizziness, weakness, fainting, bluish-colored fingernails, convulsions. If you experience this, call your doctor immediately.

Storage Tablets should be stored at room temperature between 25-25 C (68-70 F) away from light and moisture.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Oretic

Oretic

Oretic is commonly prescribed to control high blood pressure and treat water retention. The diuretic works by increasing the amount of salt and water removed from the blood, which causes a decrease in blood volume and a drop in blood pressure. The medication comes in tablet and capsule form, and is typically taken once a day. Possible side effects include nausea, electrolyte imbalances, dizziness, or vomiting.

What Is Oretic?

Oretic ® (hydrochlorothiazide ) is a prescription medicine used to treat high blood pressure and fluid retention. It is part of a class of medicines known as diuretics.

Oretic is sold under a number of other brand names, including Esidrix ®. HydroDIURIL ®. and Microzide ®. It is also available as a generic medicine. Oretic is sometimes referred to as just HCTZ or HCT.

This medication has not been approved for use in children.

Side Effects of Oretic

As with any medicine, side effects are possible with Oretic. However, not everyone who takes the drug will experience side effects. If side effects do occur, they are often minor, meaning that they require no treatment or are easily treated by you or your healthcare provider. Serious side effects are less common.

The most common side effects of Oretic seen in people taking it for high blood pressure include:

Low blood potassium levels (hypokalemia) or other electrolyte imbalances

Dizziness

Upset stomach (nausea) or vomiting.

(Click Side Effects of Hydrochlorothiazide to learn more, including potentially serious side effects to look out for.)

You can also read about other possible side effects by going to the following eMedTV articles:

Petzl Grillon - Midwest Unlimited, Griolon

Adjustable lanyard for work positioning

Lanyard with fine adjustment system for precise work positioning

Can be used in two ways 1. - Single mode on the harness ventral attachment point, to distribute weight between the waistbelt and the leg loops (user is suspended): length is adjusted by operating the handle while holding the free end of the lanyard

2. Double mode, on the harness lateral attachment points, to distribute the weight on the belt (user has weight on his feet): length is adjusted by pressing on the pivoting cam)

Removable protective sheath protects the rope from abrasive contact and favors smooth rope glide. The protection can be removed when the single lanyard technique is used, to bring the user closer to the anchor.

CERTIFICATION: CE EN 358

NOTE: GRILLON lanyards can also be used to create adjustable anchors or horizontal lifelines; please see specific versions of GRILLON lanyards for these uses

Standard Grillon has two ends that are stitched and fitted with plastic protectors.

Available in several lengths: - GRILLON (L52A 002): 6'7" (2 m, 435 g) - GRILLON (L52A 003): 9'10" (3 m, 515 g) - GRILLON (L52A 004): 13'4" (4 m, 595 g) - GRILLON (L52A 005): 16'5" (5 m, 675 g) - GRILLON (L52A 010): 32'10" (10 m, 1055 g) - GRILLON (L52A 020): 65'7" (20 m, 1900 g)

Replacement ROPES ONLY can be found here.

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Fexofenadine - Fda Prescribing Information, Side Effects And Uses, Fexofenadinum

Fexofenadine

Table 3 lists adverse reactions in subjects 6 months to 5 years of age which were reported by greater than 2% of subjects treated with Fexofenadine hydrochloride in 3 open single - and multiple-dose pharmacokinetic studies and 3 placebo-controlled safety studies with Fexofenadine hydrochloride capsule content (484 subjects) and suspension (50 subjects) at doses of 15 mg (108 subjects) and 30 mg (426 subjects) given twice a day.

Table 3: Adverse Reactions Reported in Placebo-Controlled Studies in Pediatric Subjects With Allergic Rhinitis Aged 6 Months to 5 Years of Age at Rates Greater Than 2%

Fexofenadine 15 mg Twice Daily (n = 108) Frequency

Fexofenadine 30 mg Twice Daily (n = 426) Frequency

Fexofenadine Total Twice Daily (n = 534) Frequency

Placebo (n = 430) Frequency

Chronic Idiopathic Urticaria

Adverse reactions reported by subjects 12 years of age and older in placebo-controlled chronic idiopathic urticaria studies were similar to those reported in placebo-controlled seasonal allergic rhinitis studies.

In placebo-controlled chronic idiopathic urticaria clinical trials, 726 subjects 12 years of age and older received Fexofenadine hydrochloride tablets at doses of 20 to 240 mg twice daily. Table 4 lists adverse reactions in subjects aged 12 years and older which were reported by greater than 2% of subjects treated with Fexofenadine hydrochloride 60 mg tablets twice daily in controlled clinical studies in the United States and Canada.

In a placebo-controlled clinical study in the United States, 167 subjects aged 12 years and older received Fexofenadine hydrochloride 180 mg tablets. Table 4 also lists adverse reactions that were reported by greater than 2% of subjects treated with Fexofenadine hydrochloride tablets at doses of 180 mg once daily.

Table 4: Adverse Reactions Reported in Subjects 12 Years of Age and Older in Placebo-Controlled Chronic Idiopathic Urticaria Studies

Twice-daily dosing with Fexofenadine hydrochloride in studies in the United States and Canada at rates of greater than 2%

Fexofenadine 60 mg Twice Daily (n = 191) Frequency

The safety of Fexofenadine hydrochloride in the treatment of chronic idiopathic urticaria in pediatric patients 6 months to 11 years of age is based on the safety profile of Fexofenadine hydrochloride in adults and pediatric patients at doses equal to or higher than the recommended dose [ see Use in Specific Populations (8.4 ) ].

Postmarketing Experience

In addition to the adverse reactions reported during clinical studies and listed above, the following adverse events have been identified during post-approval use of Fexofenadine hydrochloride. Because these events are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Events that have been reported rarely during postmarketing experience include: insomnia, nervousness, sleep disorders or paroniria, and hypersensitivity reactions (including anaphylaxis, urticaria, angioedema, chest tightness, dyspnea, flushing, pruritus, and rash).

Drug Interactions

Antacids

Fexofenadine hydrochloride should not be taken closely in time with aluminum and magnesium containing antacids. In healthy adult subjects, administration of 120 mg of Fexofenadine hydrochloride (2 x 60 mg capsule) within 15 minutes of an aluminum and magnesium containing antacid (Maalox ® ) decreased Fexofenadine AUC by 41% and C max by 43%.

Erythromycin and Ketoconazole

Fexofenadine has been shown to exhibit minimal (ca. 5%) metabolism. However, coadministration of Fexofenadine hydrochloride with either ketoconazole or erythromycin led to increased plasma concentrations of Fexofenadine in healthy adult subjects. Fexofenadine had no effect on the pharmacokinetics of either erythromycin or ketoconazole. In 2 separate studies in healthy adult subjects, Fexofenadine hydrochloride 120 mg twice daily (240 mg total daily dose) was coadministered with either erythromycin 500 mg every 8 hours or ketoconazole 400 mg once daily under steady-state conditions to healthy adult subjects (n = 24, each study). No differences in adverse events or QT c interval were observed when subjects were administered Fexofenadine hydrochloride alone or in combination with either erythromycin or ketoconazole. The findings of these studies are summarized in the following table:

Table 5: Effects on Steady-State Fexofenadine Pharmacokinetics After 7 Days of Coadministration With Fexofenadine Hydrochloride 120 mg Every 12 Hours in Healthy Adult Subjects (n = 24)

C maxSS (Peak plasma concentration)

AUC ss(0-12h) (Extent of systemic exposure)

The changes in plasma levels were within the range of plasma levels achieved in adequate and well-controlled clinical trials.

The mechanism of these interactions has been evaluated in in vitro, in situ. and in vivo animal models. These studies indicate that ketoconazole or erythromycin coadministration enhances Fexofenadine gastrointestinal absorption. This observed increase in the bioavailability of Fexofenadine may be due to transport-related effects, such as p-glycoprotein. In vivo animal studies also suggest that in addition to enhancing absorption, ketoconazole decreases Fexofenadine gastrointestinal secretion, while erythromycin may also decrease biliary excretion.

Fruit Juices

Fruit juices such as grapefruit, orange and apple may reduce the bioavailability and exposure of Fexofenadine. This is based on the results from 3 clinical studies using histamine induced skin wheals and flares coupled with population pharmacokinetic analysis. The size of wheal and flare were significantly larger when Fexofenadine hydrochloride was administered with either grapefruit or orange juices compared to water. Based on the literature reports, the same effects may be extrapolated to other fruit juices such as apple juice. The clinical significance of these observations is unknown. In addition, based on the population pharmacokinetics analysis of the combined data from grapefruit and orange juices studies with the data from a bioequivalence study, the bioavailability of Fexofenadine was reduced by 36%. Therefore, to maximize the effects of Fexofenadine, it is recommended that Fexofenadine hydrochloride tablets should be taken with water [ see Clinical Pharmacology (12.3 ) and Dosage and Administration (2.1 ) ].

USE IN SPECIFIC POPULATIONS

Pregnancy

Pregnancy Category C. There was no evidence of teratogenicity in rats or rabbits at oral doses of terfenadine up to 300 mg/kg (which led to Fexofenadine exposures that were approximately 4 and 30 times, respectively, the exposure at the maximum recommended human daily oral dose of 180 mg of Fexofenadine hydrochloride based on comparison of AUCs).

In mice, no adverse effects and no teratogenic effects during gestation were observed with Fexofenadine hydrochloride at oral doses up to 3730 mg/kg (which led to Fexofenadine exposures that were approximately 15 times the exposure at the maximum recommended human daily oral dose of 180 mg of Fexofenadine hydrochloride based on comparison of AUCs).

There are no adequate and well controlled studies in pregnant women. Fexofenadine hydrochloride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Dose-related decreases in pup weight gain and survival were observed in rats exposed to an oral dose of 150 mg/kg of terfenadine (which led to Fexofenadine exposures that were approximately 3 times the exposure at the maximum recommended human daily oral dose of 180 mg of Fexofenadine hydrochloride based on comparison of AUCs).

Nursing Mothers

It is not known if Fexofenadine is excreted in human milk. There are no adequate and well-controlled studies in women during lactation. Because many drugs are excreted in human milk, caution should be exercised when Fexofenadine hydrochloride is administered to a nursing woman.

Pediatric Use

The recommended doses of Fexofenadine hydrochloride in pediatric patients 6 months to 11 years of age are based on cross-study comparison of the pharmacokinetics of Fexofenadine in adults and pediatric subjects and on the safety profile of Fexofenadine hydrochloride in both adult and pediatric subjects at doses equal to or higher than the recommended doses. The safety and effectiveness of Fexofenadine hydrochloride in pediatric patients under 6 months of age have not been established.

The safety of Fexofenadine hydrochloride is based on the administration of Fexofenadine hydrochloride tablets at a dose of 30 mg twice daily demonstrated in 438 pediatric subjects 6 years to 11 years of age in 2 placebo-controlled 2 week seasonal allergic rhinitis trials. The safety of Fexofenadine hydrochloride at doses of 15 mg and 30 mg given once and twice a day has been demonstrated in 969 pediatric subjects (6 months to 5 years of age) with allergic rhinitis in 3 pharmacokinetic studies and 3 safety studies. The safety of Fexofenadine hydrochloride for the treatment of chronic idiopathic urticaria in subjects 6 months to 11 years of age is based on cross-study comparison of the pharmacokinetics of Fexofenadine hydrochloride in adult and pediatric subjects and on the safety profile of Fexofenadine in both adult and pediatric subjects at doses equal to or higher than the recommended dose.

The effectiveness of Fexofenadine hydrochloride for the treatment of seasonal allergic rhinitis in subjects 6 to 11 years of age was demonstrated in 1 trial (n = 411) in which Fexofenadine hydrochloride tablets 30 mg twice daily significantly reduced total symptom scores compared to placebo, along with extrapolation of demonstrated efficacy in subjects aged 12 years and above, and the pharmacokinetic comparisons in adults and children. The effectiveness of Fexofenadine hydrochloride 30 mg twice daily for the treatment of seasonal allergic rhinitis in patients 2 to 5 years of age is based on the pharmacokinetic comparisons in adult and pediatric subjects and an extrapolation of the demonstrated efficacy of Fexofenadine hydrochloride in adult subjects with this condition and the likelihood that the disease course, pathophysiology, and the drug’s effect are substantially similar in pediatric patients to those in adult patients. The effectiveness of Fexofenadine hydrochloride for the treatment of chronic idiopathic urticaria in patients 6 months to 11 years of age is based on the pharmacokinetic comparisons in adults and children and an extrapolation of the demonstrated efficacy of Fexofenadine hydrochloride in adults with this condition and the likelihood that the disease course, pathophysiology and the drug’s effect are substantially similar in children to that of adult patients. Administration of a 15 mg dose of Fexofenadine hydrochloride to pediatric subjects 6 months to less than 2 years of age and a 30 mg dose to pediatric subjects 2 to 11 years of age produced exposures comparable to those seen with a dose of 60 mg administered to adults.

Geriatric Use

Clinical studies of Fexofenadine hydrochloride tablets and capsules did not include sufficient numbers of subjects aged 65 years and over to determine whether this population responds differently from younger subjects. Other reported clinical experience has not identified differences in responses between the geriatric and younger subjects. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function [ see Clinical Pharmacology (12.3 ) ].

Renal Impairment

Based on increases in bioavailability and half-life, a dose of 60 mg once daily is recommended as the starting dose in adult patients with decreased renal function (mild, moderate or severe renal impairment). For pediatric patients with decreased renal function (mild, moderate or severe renal impairment), the recommended starting dose of Fexofenadine is 30 mg once daily for patients 2 to 11 years of age and 15 mg once daily for patients 6 months to less than 2 years of age [ see Clinical Pharmacology (12.3 ) ].

Hepatic Impairment

The pharmacokinetics of Fexofenadine hydrochloride in subjects with hepatic impairment did not differ substantially from that observed in healthy subjects.

Overdosage

Dizziness, drowsiness, and dry mouth have been reported with Fexofenadine hydrochloride overdose. Single doses of Fexofenadine hydrochloride up to 800 mg (6 healthy subjects at this dose level), and doses up to 690 mg twice daily for 1 month (3 healthy subjects at this dose level) or 240 mg once daily for 1 year (234 healthy subjects at this dose level) were administered without the development of clinically significant adverse events as compared to placebo.

In the event of overdose, consider standard measures to remove any unabsorbed drug. Symptomatic and supportive treatment is recommended. Following administration of terfenadine, hemodialysis did not effectively remove Fexofenadine, the major active metabolite of terfenadine, from blood (up to 1.7% removed).

No deaths occurred at oral doses of Fexofenadine hydrochloride up to 5000 mg/kg in mice (110 times the maximum recommended daily oral dose in adults and children based on mg/m 2 ) and up to 5000 mg/kg in rats (230 times the maximum recommended daily oral dose in adults and 210 times the maximum recommended daily oral dose in children based on mg/m 2 ). Additionally, no clinical signs of toxicity or gross pathological findings were observed. In dogs, no evidence of toxicity was observed at oral doses up to 2000 mg/kg (300 times the maximum recommended daily oral dose in adults and 280 times the maximum recommended daily oral dose in children based on mg/m 2 ).

Fexofenadine Description

Fexofenadine hydrochloride, the active ingredient of Fexofenadine hydrochloride tablets, is a histamine H 1 - receptor antagonist with the chemical name (±)-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl]-α, α-dimethyl benzeneacetic acid hydrochloride. It has the following chemical structure:

C 32 H 39 NO 4 •HCl M. W. 538.13

Fexofenadine hydrochloride is a white to off-white crystalline powder. It is freely soluble in methanol and ethanol, slightly soluble in chloroform and water, and insoluble in hexane. Fexofenadine hydrochloride is a racemate and exists as a zwitterion in aqueous media at physiological pH.

Fexofenadine hydrochloride is formulated as a tablet for oral administration. Each tablet contains 30, 60, or 180 mg Fexofenadine hydrochloride (depending on the dosage strength) and the following excipients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, iron oxide black, iron oxide red, iron oxide yellow, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, and titanium dioxide.

Fexofenadine hydrochloride tablets meet USP Dissolution Test 3 .

Fexofenadine - Clinical Pharmacology

Mechanism of Action

Fexofenadine hydrochloride, the major active metabolite of terfenadine, is an antihistamine with selective H 1 - receptor antagonist activity. Both enantiomers of Fexofenadine hydrochloride displayed approximately equipotent antihistaminic effects. Fexofenadine hydrochloride inhibited antigen-induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells in rats. The clinical significance of these findings is unknown. In laboratory animals, no anticholinergic or alpha 1 - adrenergic blocking effects were observed. Moreover, no sedative or other central nervous system effects were observed. Radiolabeled tissue distribution studies in rats indicated that Fexofenadine does not cross the blood-brain barrier.

Pharmacodynamics

Wheal and Flare: Human histamine skin wheal and flare studies in adults following single and twice daily doses of 20 and 40 mg Fexofenadine hydrochloride demonstrated that the drug exhibits an antihistamine effect by 1 hour, achieves maximum effect at 2 to 3 hours, and an effect is still seen at 12 hours. There was no evidence of tolerance to these effects after 28 days of dosing. The clinical significance of these observations is unknown.

Histamine skin wheal and flare studies in 7 to 12 year old subjects showed that following a single dose of 30 or 60 mg, antihistamine effect was observed at 1 hour and reached a maximum by 3 hours. Greater than 49% inhibition of wheal area, and 74% inhibition of flare area were maintained for 8 hours following the 30 and 60 mg dose.

No statistically significant increase in mean QT c interval compared to placebo was observed in 714 adult subjects with seasonal allergic rhinitis given Fexofenadine hydrochloride capsules in doses of 60 to 240 mg twice daily for 2 weeks. Pediatric subjects from 2 placebo-controlled trials (n = 855) treated with up to 60 mg Fexofenadine hydrochloride twice daily demonstrated no significant treatment - or dose-related increases in QT c. In addition, no statistically significant increase in mean QT c interval compared to placebo was observed in 40 healthy adult subjects given Fexofenadine hydrochloride as an oral solution at doses up to 400 mg twice daily for 6 days, or in 230 healthy adult subjects given Fexofenadine hydrochloride 240 mg once daily for 1 year. In subjects with chronic idiopathic urticaria, there were no clinically relevant differences for any ECG intervals, including QT c. between those treated with Fexofenadine hydrochloride 180 mg once daily (n = 163) and those treated with placebo (n = 91) for 4 weeks.

Pharmacokinetics

The pharmacokinetics of Fexofenadine hydrochloride in subjects with seasonal allergic rhinitis and subjects with chronic urticaria were similar to those in healthy subjects.

Fexofenadine hydrochloride was absorbed following oral administration of a single dose of two 60 mg capsules to healthy male subjects with a mean time to maximum plasma concentration occurring at 2.6 hours post-dose. After administration of a single 60 mg capsule to healthy adult subjects, the mean maximum plasma concentration (C max ) was 131 ng/mL. Following single dose oral administrations of either the 60 and 180 mg tablet to healthy adult male subjects, mean C max were 142 and 494 ng/mL, respectively. The tablet formulations are bioequivalent to the capsule when administered at equal doses. Fexofenadine hydrochloride pharmacokinetics are linear for oral doses up to a total daily dose of 240 mg (120 mg twice daily). The administration of the 60 mg capsule contents mixed with applesauce did not have a significant effect on the pharmacokinetics of Fexofenadine in adults. Coadministration of 180 mg Fexofenadine hydrochloride tablet with a high fat meal decreased the mean area under the curve (AUC) and (C max ) of Fexofenadine by 21 and 20% respectively.

Fexofenadine hydrochloride is 60% to 70% bound to plasma proteins, primarily albumin and α 1 - acid glycoprotein.

Approximately 5% of the total dose of Fexofenadine hydrochloride was eliminated by hepatic metabolism.

The mean elimination half-life of Fexofenadine was 14.4 hours following administration of 60 mg twice daily in healthy adult subjects.

Human mass balance studies documented a recovery of approximately 80% and 11% of the [ 14 C] Fexofenadine hydrochloride dose in the feces and urine, respectively. Because the absolute bioavailability of Fexofenadine hydrochloride has not been established, it is unknown if the fecal component represents primarily unabsorbed drug or is the result of biliary excretion.

Pharmacokinetics in renally and hepatically impaired subjects and geriatric subjects, obtained after a single dose of 80 mg Fexofenadine hydrochloride, were compared to those from healthy subjects in a separate study of similar design.

In subjects with mild to moderate (creatinine clearance 41 to 80 mL/min) and severe (creatinine clearance 11 to 40 mL/min) renal impairment, peak plasma concentrations of Fexofenadine were 87% and 111% greater, respectively, and mean elimination half-lives were 59% and 72% longer, respectively, than observed in healthy subjects. Peak plasma concentrations in subjects on dialysis (creatinine clearance ≤ 10 mL/min) were 82% greater and half-life was 31% longer than observed in healthy subjects. Based on increases in bioavailability and half-life, a dose of 60 mg once daily is recommended as the starting dose in adult patients with decreased renal function. For pediatric patients with decreased renal function, the recommended starting dose of Fexofenadine is 30 mg once daily for patients 2 to 11 years of age and 15 mg once daily for patients 6 months to less than 2 years of age.

The pharmacokinetics of Fexofenadine hydrochloride in subjects with hepatic impairment did not differ substantially from that observed in healthy subjects.

In older subjects (≥ 65 years old), peak plasma levels of Fexofenadine were 99% greater than those observed in younger subjects (< 65 years old). Mean Fexofenadine elimination half-lives were similar to those observed in younger subjects.

A population pharmacokinetic analysis was performed with data from 77 pediatric subjects (6 months to 12 years of age) with allergic rhinitis and 136 adult subjects. The individual apparent oral clearance estimates of Fexofenadine were on average 44% and 36% lower in pediatric subjects 6 to 12 years (n = 14) and 2 to 5 years of age (n = 21), respectively, compared to adult subjects.

Administration of a 15 mg dose of Fexofenadine hydrochloride to pediatric subjects 6 months to less than 2 years of age and a 30 mg dose to pediatric subjects 2 to 11 years of age produced exposures comparable to those seen with a dose of 60 mg administered to adults.

Effect of Gender:

Across several trials, no clinically significant gender-related differences were observed in the pharmacokinetics of Fexofenadine hydrochloride.

Nonclinical Toxicology

Carcinogenesis, Mutagenesis, Impairment of Fertility

The carcinogenic potential of Fexofenadine was assessed using terfenadine studies with adequate Fexofenadine exposure (based on plasma area-under-the-concentration vs. time [AUC] values). No evidence of carcinogenicity was observed in an 18 month study in mice and in a 24 month study in rats at oral doses up to 150 mg/kg of terfenadine (which led to Fexofenadine exposures that were approximately 3 and 5 times the exposure at the maximum recommended daily oral dose of Fexofenadine hydrochloride in adults [180 mg] and children [60 mg] respectively).

In in vitro (Bacterial Reverse Mutation, CHO/HGPRT Forward Mutation, and Rat Lymphocyte Chromosomal Aberration assays) and in vivo (Mouse Bone Marrow Micronucleus assay) tests, Fexofenadine hydrochloride revealed no evidence of mutagenicity.

In rat fertility studies, dose-related reductions in implants and increases in postimplantation losses were observed at an oral dose of 150 mg/kg of terfenadine (which led to Fexofenadine exposures that were approximately 3 times the exposure at the maximum recommended human daily oral dose of 180 mg of Fexofenadine hydrochloride based on comparison of AUCs). In mice, Fexofenadine hydrochloride produced no effect on male or female fertility at average oral doses up to 4438 mg/kg (which led to Fexofenadine exposures that were approximately 13 times the exposure at the maximum recommended human daily oral dose of 180 mg of Fexofenadine hydrochloride based on comparison of AUCs).

Animal Toxicology and/or Pharmacology

In dogs (30 mg/kg/orally twice daily for 5 days) and rabbits (10 mg/kg, intravenously over 1 hour), Fexofenadine hydrochloride did not prolong QT c. In dogs, the plasma Fexofenadine concentration was approximately 9 times the therapeutic plasma concentrations in adults receiving the maximum recommended human daily oral dose of 180 mg. In rabbits, the plasma Fexofenadine concentration was approximately 20 times the therapeutic plasma concentration in adults receiving the maximum recommended human daily oral dose of 180 mg. No effect was observed on calcium channel current, delayed K + channel current, or action potential duration in guinea pig myocytes, or on the delayed rectifier K + channel cloned from human heart at concentrations up to 1 x 10 -5 M of Fexofenadine.

Clinical Studies

Seasonal Allergic Rhinitis

Adults: In three 2 week, multicenter, randomized, double-blind, placebo-controlled trials in subjects 12 to 68 years of age with seasonal allergic rhinitis (n = 1634), Fexofenadine hydrochloride 60 mg twice daily significantly reduced total symptom scores (the sum of the individual scores for sneezing, rhinorrhea, itchy nose/palate/throat, itchy/watery/red eyes) compared to placebo. Statistically significant reductions in symptom scores were observed following the first 60 mg dose, with the effect maintained throughout the 12 hour interval. In these studies, there was no additional reduction in total symptom scores with higher doses of Fexofenadine hydrochloride up to 240 mg twice daily.

In one 2 week, multicenter, randomized, double-blind clinical trial in subjects 12 to 65 years of age with seasonal allergic rhinitis (n = 863), Fexofenadine hydrochloride 180 mg once daily significantly reduced total symptom scores (the sum of the individual scores for sneezing, rhinorrhea, itchy nose/palate/throat, itchy/watery/red eyes) compared to placebo. Although the number of subjects in some of the subgroups was small, there were no significant differences in the effect of Fexofenadine hydrochloride across subgroups of subjects defined by gender, age, and race. Onset of action for reduction in total symptom scores, excluding nasal congestion, was observed at 60 minutes compared to placebo following a single 60 mg Fexofenadine hydrochloride dose administered to subjects with seasonal allergic rhinitis who were exposed to ragweed pollen in an environmental exposure unit. In 1 clinical trial conducted with Fexofenadine hydrochloride 60 mg capsules, and in 1 clinical trial conducted with Fexofenadine hydrochloride and pseudoephedrine hydrochloride extended-release tablets (12 hour formulation), onset of action was seen within 1 to 3 hours.

Pediatrics: Two 2 week, multicenter, randomized, placebo-controlled, double-blind trials in 877 pediatric subjects 6 to 11 years of age with seasonal allergic rhinitis were conducted at doses of 15, 30, and 60 mg (tablets) twice daily. In 1 of these 2 studies, conducted in 411 pediatric subjects, all 3 doses of Fexofenadine hydrochloride significantly reduced total symptom scores (the sum of the individual scores for sneezing, rhinorrhea, itchy nose/palate/throat, itchy/watery/red eyes) compared to placebo, however, a dose-response relationship was not seen. The 60 mg twice daily dose did not provide any additional benefit over the 30 mg twice daily dose in pediatric subjects 6 to 11 years of age.

Administration of a 30 mg dose to pediatric subjects 2 to 11 years of age produced exposures comparable to those seen with a dose of 60 mg administered to adults [ see Clinical Pharmacology (12.3 ) ].

Chronic Idiopathic Urticaria

Two 4 week, multicenter, randomized, double-blind, placebo-controlled clinical trials compared four different doses of Fexofenadine hydrochloride tablet (20, 60, 120, and 240 mg twice daily) to placebo in subjects aged 12 to 70 years with chronic idiopathic urticaria (n = 726). Efficacy was demonstrated by a significant reduction in mean pruritus scores (MPS), mean number of wheals (MNW), and mean total symptom scores (MTSS, the sum of the MPS and MNW score). Although all 4 doses were significantly superior to placebo, symptom reduction was greater and efficacy was maintained over the entire 4 week treatment period with Fexofenadine hydrochloride doses of ≥ 60 mg twice daily. However, no additional benefit of the 120 or 240 mg Fexofenadine hydrochloride twice daily dose was seen over the 60 mg twice daily dose in reducing symptom scores. There were no significant differences in the effect of Fexofenadine hydrochloride across subgroups of subjects defined by gender, age, weight, and race.

In one 4 week, multicenter, randomized, double-blind, placebo-controlled clinical trial in subjects 12 years of age and older with chronic idiopathic urticaria (n = 259), Fexofenadine hydrochloride 180 mg once daily significantly reduced the mean number of wheals (MNW), the mean pruritus score (MPS), and the mean total symptom score (MTSS, the sum of the MPS and MNW scores). Similar reductions were observed for mean number of wheals and mean pruritus score at the end of the 24 hour dosing interval. Symptom reduction was greater with Fexofenadine hydrochloride 180 mg than with placebo. Improvement was demonstrated within 1 day of treatment with Fexofenadine hydrochloride 180 mg and was maintained over the entire 4 week treatment period. There were no significant differences in the effect of Fexofenadine hydrochloride across subgroups of subjects defined by gender, age, and race.

How Supplied/Storage and Handling

Fexofenadine hydrochloride tablets USP are available as follows:

30 mg – peach, capsule-shaped, film-coated tablets debossed with “93” on one side and “7251” on the other side, in bottles of 100.

60 mg – peach, round, film-coated tablets debossed with “93” on one side and “7252” on the other side, in bottles of 100 and 500.

180 mg – peach, round, film-coated tablets debossed with “93” on one side and “7253” on the other side, in bottles of 100 and 500.

Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Protect from excessive moisture.

Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).

Patient Counseling Information

Provide the following information to patients and parents/caregivers of pediatric patients taking Fexofenadine hydrochloride tablets:

Fexofenadine hydrochloride tablets are prescribed for the relief of symptoms of seasonal allergic rhinitis or for the relief of symptoms of chronic idiopathic urticaria (hives). Instruct patients to take Fexofenadine hydrochloride tablets only as prescribed. Do not exceed the recommended dose. If any untoward effects occur while taking Fexofenadine hydrochloride tablets, discontinue use and consult a doctor.

Patients who are hypersensitive to any of the ingredients should not use these products.

Patients who are pregnant or nursing should use these products only if the potential benefit justifies the potential risk to the fetus or nursing infant.

Advise patients and parents/caregivers of pediatric patients to store the medication in a tightly closed container in a cool, dry place, away from small children.

Advise patients and parents/caregivers not to take Fexofenadine hydrochloride tablets with fruit juices.

Advise patients to take the Fexofenadine hydrochloride tablets with water.

Maalox ® is a registered trademark of AVENTIS PHARMACEUTICALS PRODUCTS INC.

Manufactured In Israel By:

TEVA PHARMACEUTICAL IND. LTD.

Jerusalem, 91010, Israel

TEVA PHARMACEUTICALS USA

Sellersville, PA 18960

PRINCIPAL DISPLAY PANEL

Tretin-X Cream Indications, Side Effects, Warnings, Tretin

Tretin-X cream

Treating acne. It may also be used for other conditions as determined by your doctor.

Tretin-X cream is a kit that contains tretinoin cream, a cleanser, and a moisturizer. The tretinoin cream works in the skin to reduce the formation of acne and to help acne heal more quickly. The cleanser helps to keep the skin clean, and the moisturizer helps to soothe skin and keep it soft.

Do NOT use Tretin-X cream if:

you are allergic to any ingredient in Tretin-X cream

Contact your doctor or health care provider right away if this applies to you.

Before using Tretin-X cream:

Some medical conditions may interact with Tretin-X cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have eczema, an abnormally high white blood cell count, diabetes, or a sunburn

Some MEDICINES MAY INTERACT with Tretin-X cream. Tell your health care provider if you are using any other medicines, especially any of the following:

Topical medicines containing alcohol, resorcinol, sulfur, or salicylic acid because the risk of excessive skin dryness or irritation may occur

Ask your health care provider if Tretin-X cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tretin-X cream:

Use Tretin-X cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Tretin-X cream is for external use only.

In the morning, use the foaming cleanser provided in this kit to gently wash your face. Use warm water, and do not scrub. Gently pat your face dry. If your skin feels dry or rough, apply a thin layer of the moisturizer provided in this kit to your face and neck. If you are going to be outside, apply a sunscreen with an SPF of 15 or higher to your face.

At bedtime, gently wash your face again with the foaming cleanser provided in this kit. Gently pat your face dry. Wait 30 minutes for skin to dry completely. Apply the cream in this kit to areas of your skin with acne, or as directed by your doctor. Then, gently apply a thin layer of the moisturizer provided in this kit to your entire face and neck.

Wash your hands immediately after using Tretin-X cream.

If you miss a dose of Tretin-X cream, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Tretin-X cream.

Important safety information:

Tretin-X cream is for external use only. Avoid getting Tretin-X cream in your eyes, nose, or mouth. If you get Tretin-X cream in your eyes, rinse thoroughly with water.

Tretin-X cream may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Tretin-X cream. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using Tretin-X cream at this time.

Talk with your doctor before you use any other medicines or products on your skin. While you are using Tretin-X cream, you may use cosmetics.

Do not apply Tretin-X cream to skin that is sunburned. Wait until the burn is fully healed before using Tretin-X cream.

Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.

Avoid using other topical medication, cosmetics, or other products that have a strong drying effect. If you have dry skin from using these products, allow your skin to "rest" before using Tretin-X cream.

Do not use Tretin-X cream for any condition other than that for which it was prescribed.

Weather extremes, such as windy or cold weather, may irritate your skin more while you are using Tretin-X cream.

Tretin-X cream may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.

Tretin-X cream should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tretin-X cream while you are pregnant. It is not known if this medicine is found in breast milk after topical use. If you are or will be breast-feeding while you use Tretin-X cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Tretin-X cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Increase or decrease of skin pigment (color); redness, peeling, or feeling of warmth; sensitivity to sunlight; skin irritation; stinging at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe redness, swelling, blistering, or crusting of the skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately. Symptoms may include clumsiness; dizziness; excessive redness, peeling, and discomfort; flushing; headache; stomach pain. Tretin-X cream may be harmful if swallowed.

Proper storage of Tretin-X cream:

Store Tretin-X cream at room temperature, between 59 and 80 degrees F (15 and 26 degrees C). Store in a tightly closed container. Store away from heat and light. Keep Tretin-X cream out of the reach of children and away from pets.

General information:

If you have any questions about Tretin-X cream, please talk with your doctor, pharmacist, or other health care provider.

Tretin-X cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Tretin-X cream or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Tretin-X cream. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Tretin-X cream. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Tretin-X cream.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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meta keywords: midol, menstrual relief, menstrual symptoms, menstrual cramps, bloating, fatigue, headache, menstrual complete, extended relief, cramps and body aches, teen formula, menstrual headache, pms, premenstrual syndrome

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Rizendros - (Risendros - ), Tab, Pokr, Risendros

РИЗЕНДРОС® (RISENDROS®)

Торговое название: РИЗЕНДРОС® (RISENDROS®) (расширенная инструкция) (аналоги и цены)

Активное вещество: ризедроновая кислота (risedronic acid)

Международное непатентованное название: Rec. INN / зарегистрированное ВОЗ

Форма выпуска: таб. покр. пленочной оболочкой, 35 мг: 2, 4, 8 или 12 шт.

Фармакологическая группа: Костной резорбции ингибитор-бифосфонат

Клиническая группа: Ингибитор костной резорбции при остеопорозе

Регистрационный номер: ЛСР-009819/09

Дата регистрации: 2009-12-03 08:17:13

Статус регистрации: Срок действия рег. уд. не ограничен

Отпуск: По рецепту

Владелец регистрационного удостоверения: ZENTIVA, k. s. (Чешская Республика)

Произведено: ZENTIVA, k. s. (Чешская Республика)

Фасовка и упаковка: ZENTIVA, k. s. (Чешская Республика)

Представительство: ЗЕНТИВА (Чешская Республика)

Взрослым препарат назначают в дозе 35 мг 1 раз в неделю. Таблетку необходимо принимать в один и тот же день недели. Всасывание ризедроновой кислоты зависит от приема пищи, поэтому для обеспечения адекватного всасывания принимать Ризендрос ® следует не менее чем за 30 минут перед первым приемом пищи, другого лекарственного препарата или напитка (отличного от воды).

В случае пропуска приема препарата необходимо принять его в тот день, когда пациент об этом вспомнил. Затем следует вернуться к приему 1 таблетки 1 раз в неделю в день обычного приема. Не следует принимать 2 таблетки в один и тот же день.

Таблетку следует принимать целиком и не разжевывать, лучше стоя и запивать обычной водой (>120 мл). После приема таблетки больные не должны ложиться в течение 30 мин.

Во время лечения рекомендуется соблюдение адекватной диеты с достаточным содержанием кальция и витамина D. При необходимости возможно дополнительное назначение препаратов кальция и витамина D.

Большая часть нежелательных эффектов, наблюдаемых в ходе клинических исследований, были от легкой до умеренной степени тяжести, и, как правило, не требовали прекращения терапии.

Нежелательные явления перечислены ниже с условным разделением на следующие группы: очень частые (≥ 10%); частые (≥ 1% и <10%); нечастые (≥ 0.1% и <1%); редкие (≥ 0.01% и < 0,1%); очень редкие (< 0.01%).

Со стороны пищеварительной системы:

Частые: запор, диспепсия, тошнота, абдоминальные боли, диарея.

Нечастые: гастрит, эзофагит, дисфагия, дуоденит, язва пищевода.

Редкие: глоссит, стриктура пищевода.

Со стороны нервной системы:

Частые: головная боль.

Редкие: головокружение, астения, повышенная утомляемость.

Со стороны скелетно-мышечной системы:

Частые: скелетно-мышечные боли.

Редкие: судороги икроножных мышц.

Очень редко: остеонекроз челюсти (после экстракции зуба или воспаления полости рта).

Со стороны органов чувств:

Нечастые: ирит (гиперемия склеры, боль в глазах).

Редкие: амблиопия, нечеткость зрительного восприятия, сухость слизистой оболочки глаз, звон в ушах.

Прочие: инфекции (в том числе мочевыводящих путей), повышение артериального давления.

Неизвестные: частота не может быть установлена исходя из доступных данных:

• реакции аллергического типа: ангионевротический отек, крапивница;

• нарушения со стороны кожи: лейкоцитокластический васкулит, синдром Стивенса-Джонсона и токсический эпидермальный некролиз;

• серьёзные печёночные нарушения (в большинстве сообщаемых случаев пациенты также получали другие препараты, способные вызвать печёночные нарушения);

• незначительное снижение сывороточных концентраций кальция и фосфатов.

Противопоказания к применению

— повышенная чувствительность к компонентам препарата;

— тяжелое нарушение функции почек (клиренс креатина менее 30 мл/мин);

— беременность и период грудного вскармливания (лактации);

— детский возраст до 18 лет;

— при эрозивно-язвенных поражениях слизистой оболочки желудочно-кишечного тракта (в том числе в анамнезе), у больных с нарушением функции пищевода в анамнезе (таких как стриктура или ахлазия);

— при невозможности находиться в вертикальном положении, по крайней мере, 30 мин после таблетки.

Применение при беременности и кормлении грудью

Отсутствуют достаточные данные о применении ризедроната натрия у беременных женщин. Испытания на животных показали наличие репродуктивной токсичности. Потенциальный риск для человека неизвестен. Испытания на животных указывают на то, что небольшое количество ризедроната натрия проникает в грудное молоко. Ризедронат натрия не должен применяться во время беременности и в период грудного вскармливания.

Применение при нарушениях функции почек

Противопоказан при тяжелом нарушении функции почек (клиренс креатина менее 30 мл/мин).

Применение у детей

Противопоказано детям и подросткам до 18 лет.

Перед началом терапии препаратом необходимо провести коррекцию гипокальциемии, а также другой патологии, оказывающей влияние на костный и минеральный метаболизм (например, нарушения функции паращитовидных желез, дефицит витамина D). При недостаточном поступлении с пищей кальция и витамина D необходим их дополнительный прием.

Применение ряда бисфосфонатов сопровождается эзофагитом и язвенными поражениями пищевода. Поэтому больные должны строго соблюдать инструкции по дозированию и способу применения (см. раздел «Способ применения и дозы»). Особую значимость рекомендации по приему препарата имеют для пациентов с такими заболеваниями пищевода, как стриктура и ахалазия. Пациентам, которые не в состоянии находиться в течение 30 минут в вертикальном положении после приема препарата, ризедронат натрия необходимо применять с особой осторожностью из-за ограниченного клинического опыта его применения у таких больных.

Сообщалось о случаях остеонекроза челюсти после экстракции зуба и/или локального инфицирования (включая остеомиелит) у онкологических пациентов. До начала лечения бисфосфонатами у пациентов с сопутствующими факторами риска (например, онкологическое заболевание, химиотерапия, лучевая терапия, кортикостероиды, низкий уровень гигиены полости рта) следует проводить стоматологическое обследование с соответствующим терапевтическим лечением зубов. Во время лечения этим пациентам следует по возможности избегать инвазивных стоматологических вмешательств. Пища, напитки (кроме обычной воды) и лекарственные препараты, содержащие поливалентные катионы (такие как кальций, магний, железо и алюминий) препятствуют всасыванию бисфосфонатов, и их не следует принимать одновременно с ризедронатом натрия.

Влияние на способность к вождению автотранспорта и управлению механизмами

О неблагоприятном влиянии препарата Ризендрос ® на способность управлять транспортными средствами и занятие видами деятельности, требующими концентрации внимания и быстроты психомоторных реакций, не сообщалось. Но так как препарат в редких случаях может вызывать головокружение, астению и повышенную утомляемость, следует соблюдать осторожность при управлении транспортными средствами и работе с механизмами.

Симптомы (потенциально возможны): гипокальциемия.

Лечение: прием молока, назначение антацидов, содержащих магний, кальций или алюминий. При значительной передозировке для удаления неабсорбированного препарата рекомендуется провести промывание желудка.

Лекарственные средства, содержащие поливалентные катионы, такие как кальций, магний, железо и алюминий, могут снижать абсорбцию препарата.

Отсутствуют клинически значимые взаимодействия с НПВС (в т. ч. с ацетилсалициловой кислотой), блокаторами Н 2 - гистаминовых рецепторов, ингибиторами протонового насоса, антацидными лекарственными средствами, блокаторами медленных кальциевых каналов, бета-адреноблокаторами, тиазидными диуретиками, глюкокортикостероидами, антикоагулянтами, противосудорожными препаратами, сердечными гликозидами.

Препарат совместим с препаратами для ЗГТ.

Условия отпуска из аптек

Препарат отпускается по рецепту.

Dermoval - Indications, Posologie Et Effets Secondaires, Dermovel

DERMOVAL - Indications, posologie et effets secondaires

Dermoval ® est un medicament commercialise sous forme de creme. Il s'agit d'un puissant corticoide qui agit localement, il est essentiellement utilise pour traiter des affections de la peau.

Indications

Dermoval ® est indique chez les personnes affectees pas des lesions cutanees importantes, notamment les plaques cutanees associees a certaines maladies (lupus. lichens, psoriasis ), certaines cicatrices et certaines lesions non infectees qui presentent une resistance a d'autres corticoides moins forts. Ce medicament doit etre administre 1 ou 2 fois par jour. On applique la creme localement et on masse de facon circulaire afin que le produit penetre dans la peau. Il ne faut pas utiliser Dermoval ® plus de 2 fois par jour car un usage abusif eleve le risque d'effet indesirable sans pour autant augmenter la probabilite d'une guerison.

Contre-indications

Dermoval ® est contre-indique chez les personnes hypersensibles a son principe actif, le propionate de clobetasol, ou a une des substances qui le composent. Il est aussi contre-indique chez les nourrissons et chez les personnes atteintes d'une infection causee par une bacterie. un virus ou un parasite. Dermoval ®ne doit pas etre applique en cas d'ulcere. de rosacee ou d'acne ni sur les yeux.

Effets indesirables

Au meme titre que les corticoides puissants, Dermoval ® est susceptible d'entrainer quelques effets indesirables tels qu'une atrophie de la peau, un purpura. des vergetures et une peau plus fragile. Quelques cas de retard de cicatrisation d'ulceres ou de plaies. de depigmentations (decolorations de la peau) et d'eruptions d'acne chez des patients qui suivaient un traitement par Dermoval ® ont ete rapportes.

Mise en garde speciale

Les corticoides sont des medicaments qui penetrent dans la circulation generale du sujet. Dans certains cas, lorsqu'il est applique sur de grandes surfaces du corps, ce produit peut provoquer des troubles systemiques, en particulier chez les enfants. Ces troubles incluent un syndrome de Cushing et une croissance ralentie. L'interruption du traitement elimine ces symptomes mais un arret brutal peut engendrer une insuffisance surrenale aigue.

A voir également :

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DEROXAT - Paroxetine - Indications, posologie et effets secondaires

Desobel - Indications, posologie et effets secondaires

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Buy Pain Relief - Lepsitol (Brand Name Tegretol) Online - Order Cheap Carbamazepine - Purchase Pain

Tegretol (carbamazepine) is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and pain. Tegretol is used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy. Carbamazepine is also used to treat bipolar disorder. Tegretol may also be used for purposes not listed in this medication guide.

Take Tegretol exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Do not crush, chew, or break an extended-release Tegretol tablet. Swallow the pill whole. Breaking the pill would cause too much of the drug to be released at one time.

Shake the Tegretol oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and call your doctor promptly if this medicine seems to stop working as well in preventing your seizures. Tegretol can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill.

To be sure Tegretol is not causing harmful effects, your blood cells and kidney function may need to be tested often. Do not miss any follow up visits to your doctor for blood or urine tests. Your doctor may also recommend having your eyes checked regularly while you are taking this medicine.

Do not stop using Tegretol without first talking to your doctor, even if you feel fine. You may have increased seizures or unpleasant withdrawal symptoms if you stop using this medicine suddenly. Wear a medical alert tag or carry an ID card stating that you take Tegretol. Any medical care provider who treats you should know that you take seizure medication.

Store this medicine at room temperature away from moisture, heat, and light.

Active Ingredient: Carbamazepine

Tegretol may cause severe or life-threatening skin rash, especially in people of Asian ancestry. Your doctor may recommend a blood test before you start the medication to determine your risk of this skin reaction. Seek emergency medical attention if you have a fever, sore throat, headache and skin pain, followed by a red or purple skin rash that spreads and causes blistering and peeling.

You should not take Tegretol if you have a history of bone marrow suppression, if you are also taking nefazodone, or if you are allergic to an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), desipramine (Norpramin), imipramine (Tofranil), or nortriptyline (Pamelor).

Tegretol may cause harm to an unborn baby, but having a seizure during pregnancy could harm both the mother and the baby. Tell your doctor right away if you become pregnant while taking Tegretol for seizures. Do not start or stop taking Tegretol during pregnancy without your doctor's advice.

Before you take Tegretol, tell your doctor if you have heart disease, high blood pressure, high cholesterol, liver or kidney disease, glaucoma, a thyroid disorder, lupus, porphyria, or a history of mental illness or psychosis.

You may have thoughts about suicide while taking Tegretol. Your doctor will need to check you at regular visits. Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

There are many other drugs that can interact with Tegretol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Do not stop using Tegretol without first talking to your doctor, even if you feel fine. You may have increased seizures or unpleasant withdrawal symptoms if you stop using Tegretol suddenly.

Do not use Tegretol if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. You should not take Tegretol if you are allergic to carbamazepine, or if you have:

a history of bone marrow suppression

if you are also taking nefazodone; or

if you are allergic to an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), desipramine (Norpramin), imipramine (Tofranil), or nortriptyline (Pamelor).

Important safety information:

Tegretol may cause severe or life-threatening skin rash, especially in people of Asian ancestry. Your doctor may recommend a blood test before you start the medication to determine your risk of this skin reaction.

To make sure you can safely take Tegretol, tell your doctor if you have any of these other conditions:

heart disease, high blood pressure, high cholesterol or triglycerides;

liver or kidney disease;

a thyroid disorder;

a history of mental illness or psychosis.

Patients of Asian ancestry may have a higher risk of developing a rare but serious skin reaction to Tegretol. Your doctor may recommend a blood test before you start the medication to determine your risk of this skin reaction.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

You may have thoughts about suicide while taking Tegretol. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed. Seizure control is very important during pregnancy. The benefit of preventing seizures may outweigh any risks posed by taking Tegretol. Follow your doctor's instructions about taking Tegretol while you are pregnant.

FDA pregnancy category D. Tegretol may cause harm to an unborn baby. Do not start taking this medcine without telling your doctor if you are pregnant or planning to become pregnant. Use effective birth control while you are taking this medicine. Although Tegretol may harm an unborn baby, having a seizure during pregnancy could harm both mother and baby. If you become pregnant while taking Tegretol, do not stop taking the medicine without your doctor's advice.

Carbamazepine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using Tegretol. Carbamazepine can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Tegretol.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid drinking alcohol. It can increase some of the side effects of Tegretol, and can also increase your risk of seizures.

Avoid exposure to sunlight or tanning beds. Tegretol can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Grapefruit and grapefruit juice may interact with Tegretol and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction to Tegretol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

pale skin, feeling light-headed, rapid heart rate, trouble concentrating;

fever, chills, sore throat, mouth and throat ulcers;

easy bruising or bleeding, severe tingling, numbness, pain, muscle weakness;

confusion, agitation, vision problems, hallucinations;

feeling short of breath, swelling of your ankles or feet;

urinating less than usual;

jaundice (yellowing of the skin or eyes); or

severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious Tegretol side effects may include:

feeling dizzy, drowsy, or unsteady;

nausea, vomiting, diarrhea, constipation, stomach pain;

headache, ringing in your ears;

dry mouth, swollen tongue; or

joint or muscle pain, leg cramps.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Timidal, Timidal

Temodal

Active Substance: temozolomide Common Name: temozolomide ATC Code: L01AX03 Marketing Authorisation Holder: Merck Sharp & Dohme Ltd. Active Substance: temozolomide Status: Authorised Authorisation Date: 1999-01-26 Therapeutic Area: Glioblastoma Glioma Pharmacotherapeutic Group: Antineoplastic agents

Therapeutic Indication

Temodal hard capsules is indicated for the treatment of:

adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and subsequently as monotherapy treatment;

children from the age of three years, adolescents and adult patients with malignant glioma, such as glioblastoma multiforme or anaplastic astrocytoma, showing recurrence or progression after standard therapy.

What is Temodal?

Temodal is a medicine that contains the active substance temozolomide. It is available as capsules (5 mg, 20 mg, 100 mg, 140 mg, 180 mg and 250 mg) and as a powder to be made up into a solution for infusion (drip into a vein).

What is Temodal used for?

Temodal is an anticancer medicine. It is used to treat malignant glioma (brain tumours) in the following groups of patients:

adults with newly diagnosed glioblastoma multiforme (an aggressive type of brain tumour). Temodal is used first with radiotherapy and then on its own;

adults and children three years of age and over with malignant glioma such as glioblastoma multiforme or anaplastic astrocytoma, when the tumour has returned or got worse after standard treatment. Temodal is used on its own in these patients.

The medicine can only be obtained with a prescription.

How is Temodal used?

Treatment with Temodal should be prescribed by a doctor with experience in the treatment of brain tumours.

The dose of Temodal depends on body surface area (calculated using the patient’s height and weight) and ranges from 75 to 200 mg per square metre, once a day. The dose and the number of doses depend on the type of tumour being treated, whether the patient has been treated before, whether Temodal is being used alone or with radiotherapy, and how the patient responds to treatment. Temodal capsules should be taken whole without food. If the solution for infusion is used, it should be given over a period of 90 minutes. Patients may also need to take medicines to prevent vomiting before taking Temodal.

For full details, see the summary of product characteristics (also part of the EPAR).

How does Temodal work?

The active substance in Temodal, temozolomide, belongs to a group of anticancer medicines called alkylating agents. In the body, temozolomide is converted to another compound called MTIC. MTIC binds to the DNA of cells while they are reproducing, which stops cell division. As a result, the cancer cells cannot divide, slowing down the growth of tumours.

How has Temodal been studied?

Temodal capsules have been studied in four main studies.

The first study compared the effectiveness of Temodal and radiotherapy with that of radiotherapy on its own in 573 patients with newly diagnosed glioblastoma multiforme.

The other three main studies involved patients with malignant glioma that had come back or got worse after previous treatment. Two of these studies involved patients with glioblastoma multiforme: one looked at the effects of Temodal in 138 patients and the other compared Temodal with procarbazine (another anticancer medicine) in 225 patients. The final study looked at the safety and effectiveness of Temodal in the treatment of 162 patients with anaplastic astrocytoma who were in their first relapse.

The main measures of effectiveness were how long the patients survived or the length of time before the patient’s cancer started to get worse.

A further two studies were carried out in a total of 35 patients with brain tumours to show that the capsules and solution for infusion produce the same levels of temozolomide in the blood.

What benefit has Temodal shown during the studies?

In the study of newly diagnosed glioblastoma multiforme, patients survived for an average of 14.6 months when they received Temodal and radiotherapy, compared with 12.1 months with radiotherapy alone.

In the comparative study of glioblastoma multiforme that had come back or got worse after previous treatment, it took an average of 2.9 months until the cancer got worse in patients taking Temodal, compared with 1.9 months in the patients taking procarbazine. In anaplastic astrocytoma, it took an average of 5.4 months for the cancer to get worse in patients taking Temodal.

What is the risk associated with Temodal?

The most common side effects with Temodal (seen in more than 1 patient in 10) are nausea (feeling sick), vomiting, constipation, loss of appetite, alopecia (hair loss), headache, fatigue (tiredness), convulsions (fits), rash, neutropenia or lymphopenia (low white-blood-cell counts), and thrombocytopenia (low blood platelet counts). Patients receiving the solution for infusion may also have injection-site reactions, such as pain, irritation, itching, warmth, swelling and redness, as well as bruising. For the full list of all side effects reported with Temodal, see the package leaflet.

Temodal must not be used in people who are hypersensitive (allergic) to temozolomide, any of the other ingredients or dacarbazine (another anticancer medicine). Temodal must not be used in patients with severe myelosuppression (a condition in which the bone marrow cannot make enough blood cells).

Why has Temodal been approved?

The CHMP decided that Temodal’s benefits are greater than its risks and recommended that it be given marketing authorisation.

Other information about Temodal

The European Commission granted a marketing authorisation valid throughout the European Union for Temodal on 26 January 1999.

For more information about treatment with Temodal, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.

Source: European Medicines Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Buy Cyclocur Online - Self Healing Centre, Cyclocur

Cyclocur

Medication guide about Cyclocur (Estradiol)

Brand name: Cyclocur Generic name: Estradiol

What is the most important information I should know about Cyclocur? Cyclocur increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with Cyclocur lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together with the estrogen. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with Cyclocur long-term may increase the risk of stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking Cyclocur long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. The Women’s Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50-79 years of age) during 5 years of treatment with oral conjugated estrogens combined with medroxyprogesterone acetate. The Women’s Health Initiative Memory Study (WHIMS) found that postmenopausal women 65 years of age or older who were treated with oral conjugated estrogens plus medroxyprogesterone acetate had an increased risk of developing dementia. It is unknown whether this finding applies to younger postmenopausal women or to women using estrogen only therapy. Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking Cyclocur. Do not take Cyclocur if you are pregnant.

What is Cyclocur? Cyclocur is a form of estrogen. Estrogen is a female sex hormone necessary for many processes in the body. Cyclocur is used to treat symptoms of menopause such as hot flashes and dryness, burning, and irritation in the vaginal area; deficiency in ovary function (including underdevelopment of female sexual characteristics and some types of infertility); Turner’s syndrome; some types of breast cancer in men and in postmenopausal women; degeneration of the vagina and urethra; and prostate cancer. In addition, Cyclocur is used to prevent osteoporosis. Cyclocur may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking Cyclocur? Do not take Cyclocur without first talking to your doctor if you have a circulation, bleeding, or blood-clotting disorder; undiagnosed, abnormal vaginal bleeding; or any type of breast, uterine, or hormone-dependent cancer. Taking Cyclocur may not be recommended in some cases if you have any of the conditions listed above. Before taking Cyclocur, tell your doctor if you have high blood pressure, angina, or heart disease; a history of stroke or heart attack; high levels of cholesterol or triglycerides in the blood; liver disease; kidney disease; asthma; epilepsy; migraines; diabetes; depression; gallbladder disease; uterine fibroids; or had a hysterectomy (uterus removed). You may not be able to take Cyclocur, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. The Women’s Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50-79 years of age) during 5 years of treatment with oral conjugated estrogens combined with medroxyprogesterone acetate. The Women’s Health Initiative Memory Study (WHIMS) found that postmenopausal women 65 years of age or older who were treated with oral conjugated estrogens plus medroxyprogesterone acetate had an increased risk of developing dementia. It is unknown whether this finding applies to younger postmenopausal women or to women using estrogen only therapy. Treatment with Cyclocur long-term may increase the risk of stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking Cyclocur long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. Cyclocur is in the FDA pregnancy category X. This means that Cyclocur is known to cause birth defects in an unborn baby. Do not take this medication if you are pregnant or could become pregnant during treatment. Cyclocur may decrease milk flow and have other effects on milk composition. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take Cyclocur? Take this medication exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Cyclocur may be administered by mouth, injection, or inserted into the vagina. Your healthcare provider may administer injections of Cyclocur or will provide you with detailed instructions on how to administer the medication at home. Take each oral dose with a full glass of water. Take oral Cyclocur with food or milk to lessen stomach upset. Try to take oral doses at the same time daily. Use injectable Cyclocur exactly as directed by your healthcare provider. Do not inject any Cyclocur product that is discolored or has particles in it. Injectable Cyclocur stored at cool temperatures may develop crystals in the solution, which should dissolve as the solution warms to room temperature. Rotate injection sites as directed. Never reuse a needle or syringe. Dispose of all needles and syringes in an appropriate, puncture resistant disposal container. The Femring vaginal ring is inserted into the vaginal by you or your healthcare provider. To use the Femring vaginal ring: Wash and dry your hands. Remove Femring from the pouch. Squeeze the sides of the ring together or squeeze it into a figure-eight shape. Push the folded ring into the vagina (up and towards the lower back) as far as possible (into the upper 1/ 3 of the vagina). You should not be able to feel the ring once it is in position. If you can feel it, use a finger to push it further into the vagina. It is not possible for the ring to go too far in or become lost. The ring should remain in place for 3 months. It should then be removed and replaced by a new ring, if prescribed by your doctor. To remove the ring, loop a finger through the ring and gently pull it from the vagina. The ring does not need to be removed during sexual intercourse. It should not be felt by either partner. If it is bothersome, it can be removed, rinsed with warm water, and reinserted following intercourse. If at any time the ring falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use a finger to reinsert it. If the ring falls out repeatedly, talk to your doctor. To use the Estrogel pump: Before using the pump for the first time, it must be primed. Remove the large pump cover and fully depress the pump twice. Discard the unused gel by rinsing down the sink or placing it in the household trash in a manner that avoids accidental exposure or ingestion by household members or pets. Apply EstroGel at the same time each day. You should apply your daily dose of gel to clean, dry, unbroken skin. To apply the dose, collect the gel into the palm of your hand by pressing the pump firmly. Apply the gel to one arm using your hand. Spread the gel as thinly as possible over the entire area on the inside and outside of your arm from wrist to shoulder. It is not necessary to massage or rub in the gel. Allow the gel to dry for up to five minutes before dressing. Wash your hands with soap and water after applying the gel to reduce the chance that the medicine will spread from your hands to other people. Alcohol based gels are flammable. Avoid fire, flame or smoking until the gel has dried. It is important to use Cyclocur regularly to get the most benefit. Your doctor may want you to have regularly scheduled blood tests or other medical evaluations during treatment with Cyclocur to monitor progress and side effects. Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking Cyclocur. Store Cyclocur at room temperature away from moisture, heat, and direct light.

What happens if I miss a dose? Use the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and use only the next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose? An overdose of this medication is unlikely to threaten life. Consult an emergency room or poison control left for advice. Symptoms of an Cyclocur overdose may include nausea, vomiting, and breakthrough bleeding in women.

What should I avoid while taking Cyclocur? There are no restrictions on food, beverages, or activity while taking Cyclocur unless your doctor directs otherwise.

What are the possible side effects of Cyclocur? Cyclocur increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with Cyclocur lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together with the estrogen. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with Cyclocur long-term may increase the risk of stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking Cyclocur long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. If you experience any of the following serious side effects, stop taking Cyclocur and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); shortness or breath or pain in the chest; a painful, red, or swollen leg; abnormal vaginal bleeding; pain, swelling, or tenderness in the abdomen; severe headache or vomiting, dizziness, faintness or changes in vision or speech; yellowing of the skin or eyes; or a lump in a breast. Other, less serious side effects may be more likely to occur. Continue to take Cyclocur and talk to your doctor if you experience decreased appetite, nausea, or vomiting; swollen or tender breasts; acne or skin color changes; decreased sex drive; migraine headaches or dizziness; water retention (swollen hands, feet, or ankles); problems with wearing contact lenses; depression; or changes in menstrual cycle or breakthrough bleeding. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Cyclocur? Before taking Cyclocur, tell your doctor if you are taking any of the following medicines: an anticoagulant (blood thinner) such as warfarin (Coumadin); a thyroid medication such as Synthroid, Levoxyl, Levothroid, and others; insulin or an oral diabetes medicine such as glipizide (Glucotrol) or glyburide (Diabeta, Micronase); tamoxifen (Nolvadex); didanosine (Videx); phenytoin (Dilantin) or ethotoin (Peganone); carbamazepine (Tegretol); phenobarbital (Solfoton, Luminal); primidone (Mysoline); or rifampin (Rifadin). A dosage adjustment or special monitoring may be required during treatment if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with Cyclocur. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

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Buy Bi Moxal Amoxicillin, Clavulanate Online Without Prescriptions, Bi Moxal

Augmentin is used for treating infections caused by certain bacteria. Augmentin is a penicillin antibiotic. It works by killing sensitive bacteria.

Use Augmentin as directed by your doctor.

Take Augmentin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

To clear up your infection completely, take Augmentin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Augmentin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Augmentin.

Store Augmentin at or below 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Augmentin out of the reach of children and away from pets.

Active Ingredient: Amoxicillin/clavulanate potassium.

Do NOT use Augmentin if:

you are allergic to any ingredient in Augmentin or another penicillin antibiotic (eg, ampicillin)

you have a history of liver problems or yellowing of the eyes or skin caused by Augmentin

you have infectious mononucleosis (mono)

you are taking a tetracycline antibiotic (eg, doxycycline)

you have recently received or will be receiving live oral typhoid vaccine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Augmentin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of allergies, asthma, hay fever, or hives

if you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness) to a cephalosporin (eg, cephalexin) or another beta-lactam antibiotic (eg, imipenem)

if you have kidney problems or gonorrhea

if you have a history of liver problems or yellowing of the eyes or skin.

Some medicines may interact with Augmentin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin) because the risk of bleeding may be increased

Probenecid because it may increase the amount of Augmentin in your blood

Chloramphenicol, macrolide antibiotics (eg, erythromycin), sulfonamides (eg, sulfamethoxazole), or tetracycline antibiotics (eg, doxycycline) because they may decrease Augmentin's effectiveness

Methotrexate because the risk of its side effects may be increased by Augmentin

Live oral typhoid vaccine or hormonal birth control (eg, birth control pills) because their effectiveness may be decreased by Augmentin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Augmentin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Augmentin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Augmentin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Augmentin only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use Augmentin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Augmentin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Augmentin. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Brown, yellow, or gray tooth discoloration has occurred rarely in some patients taking Augmentin. It occurred most often in children. The discoloration was reduced or removed by brushing or dental cleaning in most cases. Contact your doctor if you experience this effect.

Diabetes patients - Augmentin may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.

Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed if you use Augmentin for a long period of time. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Augmentin with caution in the elderly; they may be more sensitive to its effects, especially patients with kidney problems.

Use Augmentin with extreme caution in children younger than 10 years old who have diarrhea or an infection of the stomach or bowel.

Augmentin should not be used in children who weigh less than 88 lbs (40 kg); safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Augmentin while you are pregnant. Augmentin is found in breast milk. If you are or will be breast-feeding while you use Augmentin, check with your doctor. Discuss any possible risks to your baby.

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