Cyproheptadine - Side Effects, Dosage, Interactions, Heptodine

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Cyproheptadine is a prescription medication used to relieve allergy symptoms, itching, and to increase appetite.

Cyproheptadine belongs to group of drugs known as first-generation antihistamines.

It works by blocking the release of histamine, a chemical in the body that causes allergic responses such as a runny nose, watery eyes, sneezing, and itching.

Cyproheptadine was originally approved by the Food and Drug Administration (FDA) under the brand name Periactin in 1961 and was manufactured by Merck Pharmaceuticals.

Periactin is no longer on the market, and the only form currently available is generic cyproheptadine.

Cyproheptadine Warnings

You should not take cyproheptadine if:

You are allergic to cyproheptadine, any similar drugs, or any other ingredients found in the drug

You live in a place where the weather is very hot most of the time

You have a blockage in the opening of your bladder

You are breastfeeding

You have glaucoma (especially if it is angle-closure glaucoma)

You have ulcers

You are 65 years of age or older

It's not recommended that newborn babies, premature babies, or children under the age of 2 take cyproheptadine.

Also, cyproheptadine can cause some very dangerous side effects in people who are 65 years of age or older, like confusion, drowsiness, and dizziness, which can make them more susceptible to falls and other serious accidents.

Talk to your doctor before taking cyproheptadine if you have kidney or liver problems.

Pregnancy and Cyproheptadine

Cyproheptadine falls under the FDA's Pregnancy Category B, which means that harm to a developing fetus is unlikely.

Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

It's not recommended that breastfeeding mothers take cyproheptadine. You should talk to your doctor if you are breastfeeding or plan to breastfeed.

It's always important to tell your doctor and pharmacist all of the medications you are taking.

This includes prescription and over-the-counter medications, supplements like vitamins and other dietary supplements (nutritional shakes, protein powders, etc.), herbals, and any illegal or recreational drugs.

You should not take cyproheptadine if you are taking the following drugs:

Klor-Con (potassium chloride)

Urocit-K (potassium citrate)

K-Phos (potassium acid phosphate or potassium phosphate)

Some other medications that have serious interactions with cyproheptadine include:

Monoamine oxidase inhibitors (MAOIs) like Marplan (isocarboxazid), Nardil (phenelzine), and Matulane (procarbazine)

Symlin (pramlinitide)

Parkinson's disease medications like Azilect (rasagiline), Zelapar or Eldepryl (selegeline and selegeline transdermal), and tranylcypromine

Benzodiazepines like Xanax (alprazolam), Klonopin (clonazepam), and Ativan (lorazepam)

Opiates like Zohydro and Zotripro (hydrocodone), Dilaudid (hydromorphone), and Avinza, Astromorph, MS Contin, and Kadian (morphine)

Sleeping medications like Ambien (zolpidem), Lunesta (eszopiclone), and Sonata (zaleplon)

Cyproheptadine and Alcohol

Both cyproheptadine and alcohol can make you sleepy and cause dehydration and poor concentration.

Therefore, consuming alcoholic beverages while taking cyproheptadine is not recommended because it may make these symptoms worse.

Cyproheptadine and Grapefruit Juice

Avoid eating grapefruit and drinking grapefruit juice while taking cyproheptadine.

Grapefruit juice slows down how quickly the body is able to break down cyproheptadine, which could cause levels in the blood to rise dangerously high.