Nizoral - Anti Fungal, Zoloral

Product Description Common use Nizoral is an antifungal antibiotic used to treat serious fungal or yeast infections, such as candidiasis, blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis, or paracoccidioidomycosis. Nizoral kills sensitive fungi by interfering with the formation of the fungal cell membrane. Also Nizoral is used to treat parasitic fungal infections on the skin that cannot be treated with topical medicine or griseofulvin, or for patients who cannot take griseofulvin.

Dosage and direction Take it orally with food or milk at the same time each day. The recommended starting dose for adults is 200 mg once a day. Dosage for 2-year-old children is based on body weight. A single daily dose varies from 3.3 to 6.6 mg/kg. Do not use it without doctor's permission and dose has to be prescribed just after consulting your doctor. For children under the age of 2, use it just after doctor's permission and dose has to be prescribed after consulting your doctor. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using.

Precautions Liver problems may occur while you are taking this medicine. If you experience one of this symptoms as dark urine; abdominal pain or tenderness; clay-colored stools; nausea and vomiting; decreased appetite; skin rash; fever; headache; itching; loss of appetite; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin call your doctor immediately. Nizoral should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use this drug before breast-feeding without doctor's permission.

Nizoral is not allowed to people who are hypersensitive to any components of this medication. Also it is contraindicated with terfenadine, astemizole, triazolam, cisapride.

Possible side effect They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: dizziness, fainting, fast or pounding heartbeat; easy bruising or bleeding, unusual weakness; numbness or tingly feeling; severe depression, confusion, or thoughts of hurting yourself; or nausea, stomach pain, low fever, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious include: mild nausea, vomiting, or stomach pain; mild itching or skin rash; headache; dizziness; breast swelling; or impotence or loss of interest in sex. If you experience one of them stop using Nizoral and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Nizoral interact with follow list of drugs: acetaminophen (Tylenol); cyclosporine (Gengraf, Sandimmune, Neoral); digoxin (digitalis, Lanoxin); tacrolimus ((Prograf); loratadine (Alavert, Claritin, Tavist ND); methylprednisolone (Medrol); phenytoin (Dilantin); rifampin (Rifadin, Rifater, Rifamate, Rimactane); diabetes medication you take by mouth; a sedative such as midazolam (Versed); a blood thinner such as warfarin (Coumadin); cancer medications; birth control pills or hormone replacement therapy; methotrexate (Rheumatrex, Trexall); cholesterol medications such as niacin (Advicor), atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and others; or medications to treat HIV or AIDS. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.

Symptoms of Nizoral overdose are not known well, but if you experience any unusual symptoms call your doctor immediately. Also in the event of accidental over-dosage, supportive measures, including gastric lavage with sodium bicarbonate, should be employed.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Product Description Common use Nizoral is an antifungal antibiotic used to treat serious fungal or yeast infections, such as candidiasis, blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis, or paracoccidioidomycosis. Nizoral kills sensitive fungi by interfering with the formation of the fungal cell membrane. Also Nizoral is used to treat parasitic fungal infections on the skin that cannot be treated with topical medicine or griseofulvin, or for patients who cannot take griseofulvin.

Dosage and direction Take it orally with food or milk at the same time each day. The recommended starting dose for adults is 200 mg once a day. Dosage for 2-year-old children is based on body weight. A single daily dose varies from 3.3 to 6.6 mg/kg. Do not use it without doctor's permission and dose has to be prescribed just after consulting your doctor. For children under the age of 2, use it just after doctor's permission and dose has to be prescribed after consulting your doctor. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using.

Precautions Liver problems may occur while you are taking this medicine. If you experience one of this symptoms as dark urine; abdominal pain or tenderness; clay-colored stools; nausea and vomiting; decreased appetite; skin rash; fever; headache; itching; loss of appetite; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin call your doctor immediately. Nizoral should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use this drug before breast-feeding without doctor's permission.

Nizoral is not allowed to people who are hypersensitive to any components of this medication. Also it is contraindicated with terfenadine, astemizole, triazolam, cisapride.

Possible side effect They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: dizziness, fainting, fast or pounding heartbeat; easy bruising or bleeding, unusual weakness; numbness or tingly feeling; severe depression, confusion, or thoughts of hurting yourself; or nausea, stomach pain, low fever, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious include: mild nausea, vomiting, or stomach pain; mild itching or skin rash; headache; dizziness; breast swelling; or impotence or loss of interest in sex. If you experience one of them stop using Nizoral and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Nizoral interact with follow list of drugs: acetaminophen (Tylenol); cyclosporine (Gengraf, Sandimmune, Neoral); digoxin (digitalis, Lanoxin); tacrolimus ((Prograf); loratadine (Alavert, Claritin, Tavist ND); methylprednisolone (Medrol); phenytoin (Dilantin); rifampin (Rifadin, Rifater, Rifamate, Rimactane); diabetes medication you take by mouth; a sedative such as midazolam (Versed); a blood thinner such as warfarin (Coumadin); cancer medications; birth control pills or hormone replacement therapy; methotrexate (Rheumatrex, Trexall); cholesterol medications such as niacin (Advicor), atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and others; or medications to treat HIV or AIDS. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.

Symptoms of Nizoral overdose are not known well, but if you experience any unusual symptoms call your doctor immediately. Also in the event of accidental over-dosage, supportive measures, including gastric lavage with sodium bicarbonate, should be employed.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Product Description Common use Nizoral is an antifungal antibiotic used to treat serious fungal or yeast infections, such as candidiasis, blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis, or paracoccidioidomycosis. Nizoral kills sensitive fungi by interfering with the formation of the fungal cell membrane. Also Nizoral is used to treat parasitic fungal infections on the skin that cannot be treated with topical medicine or griseofulvin, or for patients who cannot take griseofulvin.

Dosage and direction Take it orally with food or milk at the same time each day. The recommended starting dose for adults is 200 mg once a day. Dosage for 2-year-old children is based on body weight. A single daily dose varies from 3.3 to 6.6 mg/kg. Do not use it without doctor's permission and dose has to be prescribed just after consulting your doctor. For children under the age of 2, use it just after doctor's permission and dose has to be prescribed after consulting your doctor. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using.

Precautions Liver problems may occur while you are taking this medicine. If you experience one of this symptoms as dark urine; abdominal pain or tenderness; clay-colored stools; nausea and vomiting; decreased appetite; skin rash; fever; headache; itching; loss of appetite; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin call your doctor immediately. Nizoral should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use this drug before breast-feeding without doctor's permission.

Nizoral is not allowed to people who are hypersensitive to any components of this medication. Also it is contraindicated with terfenadine, astemizole, triazolam, cisapride.

Possible side effect They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: dizziness, fainting, fast or pounding heartbeat; easy bruising or bleeding, unusual weakness; numbness or tingly feeling; severe depression, confusion, or thoughts of hurting yourself; or nausea, stomach pain, low fever, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious include: mild nausea, vomiting, or stomach pain; mild itching or skin rash; headache; dizziness; breast swelling; or impotence or loss of interest in sex. If you experience one of them stop using Nizoral and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Nizoral interact with follow list of drugs: acetaminophen (Tylenol); cyclosporine (Gengraf, Sandimmune, Neoral); digoxin (digitalis, Lanoxin); tacrolimus ((Prograf); loratadine (Alavert, Claritin, Tavist ND); methylprednisolone (Medrol); phenytoin (Dilantin); rifampin (Rifadin, Rifater, Rifamate, Rimactane); diabetes medication you take by mouth; a sedative such as midazolam (Versed); a blood thinner such as warfarin (Coumadin); cancer medications; birth control pills or hormone replacement therapy; methotrexate (Rheumatrex, Trexall); cholesterol medications such as niacin (Advicor), atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and others; or medications to treat HIV or AIDS. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.

Symptoms of Nizoral overdose are not known well, but if you experience any unusual symptoms call your doctor immediately. Also in the event of accidental over-dosage, supportive measures, including gastric lavage with sodium bicarbonate, should be employed.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Cyproheptadine - Side Effects, Dosage, Interactions, Heptodine

Cyproheptadine

Cyproheptadine is a prescription medication used to relieve allergy symptoms, itching, and to increase appetite.

Cyproheptadine belongs to group of drugs known as first-generation antihistamines.

It works by blocking the release of histamine, a chemical in the body that causes allergic responses such as a runny nose, watery eyes, sneezing, and itching.

Cyproheptadine was originally approved by the Food and Drug Administration (FDA) under the brand name Periactin in 1961 and was manufactured by Merck Pharmaceuticals.

Periactin is no longer on the market, and the only form currently available is generic cyproheptadine.

Cyproheptadine Warnings

You should not take cyproheptadine if:

You are allergic to cyproheptadine, any similar drugs, or any other ingredients found in the drug

You live in a place where the weather is very hot most of the time

You have a blockage in the opening of your bladder

You are breastfeeding

You have glaucoma (especially if it is angle-closure glaucoma)

You have ulcers

You are 65 years of age or older

It's not recommended that newborn babies, premature babies, or children under the age of 2 take cyproheptadine.

Also, cyproheptadine can cause some very dangerous side effects in people who are 65 years of age or older, like confusion, drowsiness, and dizziness, which can make them more susceptible to falls and other serious accidents.

Talk to your doctor before taking cyproheptadine if you have kidney or liver problems.

Pregnancy and Cyproheptadine

Cyproheptadine falls under the FDA's Pregnancy Category B, which means that harm to a developing fetus is unlikely.

Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

It's not recommended that breastfeeding mothers take cyproheptadine. You should talk to your doctor if you are breastfeeding or plan to breastfeed.

It's always important to tell your doctor and pharmacist all of the medications you are taking.

This includes prescription and over-the-counter medications, supplements like vitamins and other dietary supplements (nutritional shakes, protein powders, etc.), herbals, and any illegal or recreational drugs.

You should not take cyproheptadine if you are taking the following drugs:

Klor-Con (potassium chloride)

Urocit-K (potassium citrate)

K-Phos (potassium acid phosphate or potassium phosphate)

Some other medications that have serious interactions with cyproheptadine include:

Monoamine oxidase inhibitors (MAOIs) like Marplan (isocarboxazid), Nardil (phenelzine), and Matulane (procarbazine)

Symlin (pramlinitide)

Parkinson's disease medications like Azilect (rasagiline), Zelapar or Eldepryl (selegeline and selegeline transdermal), and tranylcypromine

Benzodiazepines like Xanax (alprazolam), Klonopin (clonazepam), and Ativan (lorazepam)

Opiates like Zohydro and Zotripro (hydrocodone), Dilaudid (hydromorphone), and Avinza, Astromorph, MS Contin, and Kadian (morphine)

Sleeping medications like Ambien (zolpidem), Lunesta (eszopiclone), and Sonata (zaleplon)

Cyproheptadine and Alcohol

Both cyproheptadine and alcohol can make you sleepy and cause dehydration and poor concentration.

Therefore, consuming alcoholic beverages while taking cyproheptadine is not recommended because it may make these symptoms worse.

Cyproheptadine and Grapefruit Juice

Avoid eating grapefruit and drinking grapefruit juice while taking cyproheptadine.

Grapefruit juice slows down how quickly the body is able to break down cyproheptadine, which could cause levels in the blood to rise dangerously high.

Metoclopramide Medlineplus Drug Information, Maxeran

Metoclopramide

IMPORTANT WARNING:

Taking metoclopramide may cause you to develop a muscle problem called tardive dyskinesia. If you develop tardive dyskinesia, you will move your muscles, especially the muscles in your face in unusual ways. You will not be able to control or stop these movements. Tardive dyskinesia may not go away even after you stop taking metoclopramide. The longer you take metoclopramide, the greater the risk that you will develop tardive dyskinesia. Therefore, your doctor will probably tell you not to take metoclopramide for longer than 12 weeks. The risk that you will develop tardive dyskinesia is also greater if you are taking medications for mental illness, if you have diabetes, or if you are elderly, especially if you are a woman. Call your doctor immediately if you develop any uncontrollable body movements, especially lip smacking, mouth puckering, chewing, frowning, scowling, sticking out your tongue, blinking, eye movements, or shaking arms or legs.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with metoclopramide and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www. fda. gov/Drugs/DrugSafety/ucm085729.htm ) or the manufacturer's website to obtain the Medication Guide.

Talk to your doctor about the risks of taking metoclopramide.

Why is this medication prescribed?

Metoclopramide is used to relieve heartburn and speed the healing of ulcers and sores in the esophagus (tube that connects the mouth to the stomach) in people who have gastroesophageal reflux disease (GERD; condition in which backward flow of acid from the stomach causes heartburn and injury of the esophagus) that did not get better with other treatments. Metoclopramide is also used to relieve symptoms caused by slow stomach emptying in people who have diabetes. These symptoms include nausea, vomiting, heartburn, loss of appetite, and feeling of fullness that lasts long after meals. Metoclopramide is in a class of medications called prokinetic agents. It works by speeding the movement of food through the stomach and intestines.

How should this medicine be used?

Metoclopramide comes as a tablet, an orally disintegrating (dissolving) tablet, and a solution (liquid) to take by mouth. It is usually taken 4 times a day on an empty stomach, 30 minutes before each meal and at bedtime. When metoclopramide is used to treat symptoms of GERD, it may be taken less frequently, especially if symptoms only occur at certain times of day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metoclopramide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are taking the orally disintegrating tablet, use dry hands to remove the tablet from the package just before you take your dose. If the tablet breaks or crumbles, throw it away and remove a new tablet from the package. Gently remove the tablet and immediately place it on the top of your tongue. The tablet will usually dissolve in about one minute and can be swallowed with saliva.

If you are taking metoclopramide to treat the symptoms of slow stomach emptying caused by diabetes, you should know that your symptoms will not improve all at once. You may notice that your nausea improves early in your treatment and continues to improve over the next 3 weeks. Your vomiting and loss of appetite may also improve early in your treatment, but it may take longer for your feeling of fullness to go away.

Continue to take metoclopramide even if you feel well. Do not stop taking metoclopramide without talking to your doctor. You may experience withdrawal symptoms such as dizziness, nervousness, and headaches when you stop taking metoclopramide.

Other uses for this medicine

Metoclopramide is also sometimes used to treat the symptoms of slowed stomach emptying in people who are recovering from certain types of surgery, and to prevent nausea and vomiting in people who are being treated with chemotherapy for cancer. Ask your doctor about the risks of using this medication to treat your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Metoclopramide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

drowsiness

excessive tiredness

weakness

headache

dizziness

diarrhea

nausea

vomiting

breast enlargement or discharge

missed menstrual period

decreased sexual ability

frequent urination

inability to control urination

Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately:

tightening of the muscles, especially in the jaw or neck

speech problems

depression

thinking about harming or killing yourself

fever

muscle stiffness

confusion

fast, slow, or irregular heartbeat

sweating

restlessness

nervousness or jitteriness

agitation

difficulty falling asleep or staying asleep

pacing

foot tapping

slow or stiff movements

blank facial expression

uncontrollable shaking of a part of the body

difficulty keeping your balance

rash

hives

swelling of the eyes, face, lips, tongue, mouth, throat, arms, hands, feet, ankles, or lower legs

sudden weight gain

difficulty breathing or swallowing

high-pitched sounds while breathing

vision problems

Metoclopramide may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include

drowsiness

confusion

seizures

unusual, uncontrollable movements

lack of energy

bluish coloring of the skin

headache

shortness of breath

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

¶ This branded product is no longer on the market. Generic alternatives may be available.

Last Reviewed - 09/01/2010

American Society of Health-System Pharmacists, Inc. Disclaimer

AHFS ® Patient Medication Information. © Copyright, 2016. The American Society of Health-System Pharmacists, Inc. 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

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Revlon, Inc. New Common Stock Quote & Summary Data

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Tetrecu, Tetrecu

Tetracycline

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Sumycin is used for treating infections caused by certain bacteria. Sumycin is a tetracycline antibiotic. It works by slowing the growth of sensitive bacteria by interfering with the production of proteins needed by the bacteria to grow. Slowing the bacteria's growth allows the body's defense mechanisms to destroy them.

Use Sumycin as directed by your doctor.

Take Sumycin by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Take Sumycin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Sumycin.

If you also take antacids containing aluminum, calcium, or magnesium; preparations containing bismuth, iron, zinc, or sodium bicarbonate; or calcium rich foods (eg, milk, dairy products, calcium-enriched juices), do not take them within 2 to 3 hours before or after taking Sumycin. Check with your doctor if you have questions.

To clear up your infection completely, take Sumycin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Sumycin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sumycin.

Store Sumycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed, light-resistant container. Keep away from heat, moisture, and light. Do not store in the bathroom. Keep Sumycin out of the reach of children and away from pets.

Active Ingredient: Tetracycline hydrochloride.

Do NOT use Sumycin if:

you are allergic to any ingredient in Sumycin or other tetracycline antibiotics (eg, doxycycline)

you are taking acitretin or methoxyflurane.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Sumycin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach infection, or kidney problems.

Some medicines may interact with Sumycin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Acitretin or isotretinoin because side effects, such as increased pressure in the fluid surrounding the brain, may occur

Digoxin, methotrexate, methoxyflurane, or oral anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Sumycin

Atovaquone, lithium, oral contraceptives (birth control pills), or penicillins (eg, amoxicillin) because their effectiveness may be decreased by Sumycin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sumycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Sumycin may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Sumycin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Be sure to use Sumycin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Sumycin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Sumycin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Do not use after expiration date. Outdated medicine is highly toxic to the kidneys.

Long-term or repeated use of Sumycin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Sumycin. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Lab tests may be performed while you use Sumycin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use of Sumycin in children may cause permanent discoloring of the teeth.

Sumycin should be used with extreme caution in children younger 8 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and beast-feeding: Sumycin has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sumycin while you are pregnant. Sumycin is found in breast milk. Do not breast-feed while taking Sumycin.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Black hairy tongue; blurred vision; bulky loose stools; diarrhea; difficulty swallowing; fever; headache; hives; hoarseness; indigestion; inflammation or redness of tongue; joint pain; loss of appetite; mouth sores; nausea; rash; sensitivity to sunlight; sore throat; stomach pain; swelling and itching of the rectum.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); infection (fever, chills, sore throat); itching; nausea; severe skin reaction to the sun; vaginal irritation or discharge; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Sumycin is used for treating infections caused by certain bacteria. Sumycin is a tetracycline antibiotic. It works by slowing the growth of sensitive bacteria by interfering with the production of proteins needed by the bacteria to grow. Slowing the bacteria's growth allows the body's defense mechanisms to destroy them.

Use Sumycin as directed by your doctor.

Take Sumycin by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Take Sumycin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Sumycin.

If you also take antacids containing aluminum, calcium, or magnesium; preparations containing bismuth, iron, zinc, or sodium bicarbonate; or calcium rich foods (eg, milk, dairy products, calcium-enriched juices), do not take them within 2 to 3 hours before or after taking Sumycin. Check with your doctor if you have questions.

To clear up your infection completely, take Sumycin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Sumycin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sumycin.

Store Sumycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed, light-resistant container. Keep away from heat, moisture, and light. Do not store in the bathroom. Keep Sumycin out of the reach of children and away from pets.

Active Ingredient: Tetracycline hydrochloride.

Do NOT use Sumycin if:

you are allergic to any ingredient in Sumycin or other tetracycline antibiotics (eg, doxycycline)

you are taking acitretin or methoxyflurane.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Sumycin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach infection, or kidney problems.

Some medicines may interact with Sumycin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Acitretin or isotretinoin because side effects, such as increased pressure in the fluid surrounding the brain, may occur

Digoxin, methotrexate, methoxyflurane, or oral anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Sumycin

Atovaquone, lithium, oral contraceptives (birth control pills), or penicillins (eg, amoxicillin) because their effectiveness may be decreased by Sumycin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sumycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Sumycin may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Sumycin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Be sure to use Sumycin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Sumycin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Sumycin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Do not use after expiration date. Outdated medicine is highly toxic to the kidneys.

Long-term or repeated use of Sumycin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Sumycin. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Lab tests may be performed while you use Sumycin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use of Sumycin in children may cause permanent discoloring of the teeth.

Sumycin should be used with extreme caution in children younger 8 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and beast-feeding: Sumycin has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sumycin while you are pregnant. Sumycin is found in breast milk. Do not breast-feed while taking Sumycin.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Black hairy tongue; blurred vision; bulky loose stools; diarrhea; difficulty swallowing; fever; headache; hives; hoarseness; indigestion; inflammation or redness of tongue; joint pain; loss of appetite; mouth sores; nausea; rash; sensitivity to sunlight; sore throat; stomach pain; swelling and itching of the rectum.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); infection (fever, chills, sore throat); itching; nausea; severe skin reaction to the sun; vaginal irritation or discharge; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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What is amitriptyline?

Amitriptyline is in a group of drugs called tricyclic antidepressants. Amitriptyline affects chemicals in the brain that may become unbalanced.

Amitriptyline is used to treat symptoms of depression.

Amitriptyline may also be used for other purposes not listed in this medication guide.

Precautions

Do not use this medication if you are allergic to amitriptyline, or if you have recently had a heart attack.

Do not use amitriptyline if you have taken cisapride (Propulsid) or used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take amitriptyline before the MAO inhibitor has cleared from your body.

Before taking amitriptyline, tell your doctor if you are allergic to any drugs, or if you have:

heart disease;

a history of heart attack, stroke, or seizures;

bipolar disorder (manic-depression);

schizophrenia or other mental illness;

diabetes (amitriptyline may raise or lower blood sugar);

overactive thyroid;

glaucoma; or

problems with urination.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take amitriptyline.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Amitriptyline can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medication to anyone under 18 years old without the advice of a doctor.

Avoid drinking alcohol. It can cause dangerous side effects when taken together with amitriptyline.

Grapefruit and grapefruit juice may interact with amitriptyline. Discuss the use of grapefruit products with your doctor before increasing or decreasing the amount of grapefruit products in your diet.

Amitriptyline can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Amitriptyline can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Instructions

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of amitriptyline can be fatal.

Overdose symptoms may include uneven heartbeats, extreme drowsiness, confusion, agitation, vomiting, blurred vision, feeling hot or cold, sweating, muscle stiffness, feeling light-headed, fainting, seizure (convulsions), or coma.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

fast, pounding, or uneven heart rate, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

sudden numbness or weakness, especially on one side of the body;

sudden headache, confusion, problems with vision, speech, or balance;

hallucinations, or seizures (convulsions), feeling light-headed, fainting;

restless muscle movements in your eyes, tongue, jaw, or neck, uncontrollable shaking or tremor;

skin rash, severe tingling, numbness, pain, muscle weakness;

easy bruising or bleeding;

extreme thirst with headache, nausea, vomiting, and weakness; or

urinating less than usual or not at all.

Less serious side effects may include:

nausea, vomiting, constipation, diarrhea, loss of appetite;

dry mouth, unpleasant taste;

feeling dizzy, drowsy, or tired;

trouble concentrating;

nightmares;

blurred vision, headache, ringing in your ears;

breast swelling (in men or women); or

decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Interactions

Tell your doctor if you regularly use other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, medicine for seizures, or other antidepressants).

Before taking amitriptyline, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft).

Before taking amitriptyline, tell your doctor if you are currently using any of the following drugs:

cimetidine (Tagamet);

guanethidine (Ismelin);

disulfiram (Antabuse); or

heart rhythm medications such as flecainide (Tambocor), propafenone (Rhythmol), or quinidine (Cardioquin, Quinidex, Quinaglute).

This list is not complete and there are many other medicines that can interact with amitriptyline. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Other Names

Elavil, Endep, Vanatrip, and amitriptyline

Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

Last updated: September 20, 2016

What is the most important information I should know about amitriptyline?

Do not use this medication if you are allergic to amitriptyline, or if you have recently had a heart attack.

Do not use amitriptyline if you have taken cisapride (Propulsid) or used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Warning

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Mycelex-G (Clotrimazole) is an antifungal medication. It prevents fungus from growing.

Clotrimazole vaginal is used to treat vaginal candida (yeast) infections.

Clotrimazole vaginal may also be used for purposes other than those listed in this medication guide.

Use Mycelex-G exactly as directed by your doctor, or follow the directions that accompany the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using this medication.

Insert the tablet, suppository, or cream into the vagina using the applicator as directed.

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Avoid getting this medication in your eyes, nose, or mouth. Store clotrimazole vaginal at room temperature away from moisture and heat.

Active ingredient: Clotrimazole

Clotrimazole is an antifungal medication. It prevents fungus from growing.

Clotrimazole vaginal is used to treat vaginal candida (yeast) infections.

It also may be used for purposes other than those listed in this medication guide.

Safety information

Do not use clotrimazole vaginal if you have ever had an allergic reaction to it.

If this is the first time that you have ever had symptoms of a vaginal yeast infection, consult your doctor before using this medication.

Do not use clotrimazole vaginal if you have a fever, abdominal pain, foul-smelling discharge, diabetes, HIV, or AIDS. Consult your doctor. Do not use this medication without first talking to your doctor if you are pregnant. Do not use clotrimazole vaginal without first talking to your doctor if you are breast-feeding a baby. Do not use this medication if you are younger than 12 years of age.

Important safety information

Use this medication for the full amount of time prescribed by your doctor or recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.

Avoid wearing tight-fitting, synthetic clothing (e. g. panty hose) that does not allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed. Avoid getting this medication in your eyes, nose, or mouth.

Side effects

Stop using clotrimazole vaginal and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

Other, less serious side effects may be more likely to occur. These include burning, itching, irritation of the skin, and an increased need to urinate.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Avoid using other vaginal creams or douches at the same time as clotrimazole unless your doctor approves.

Drugs other than those listed here may also interact with clotrimazole vaginal. Talk to your doctor and pharmacist before taking any prescription or over the counter medicines.

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Your order will be packed safely and secure and dispatched within 24 hours. This is how your parcel will look like, the images are photographs of real shipments. It has the size of a normal protected envelope and it does not disclose its contents.

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enige zwakte frictiemateriaal

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pijn frictiemateriaal

verband met de werkelijke influenza frictiemateriaal

Negatieve effecten indicaties zijn vertrouwen op medicijnen die u zou kunnen gebruiken, maar bovendien rekenen op uw welzijn conditie en andere aspecten.

Catalip (Tricor) Contra-indicaties

Meestal niet Catalip te krijgen in het geval u gevoelig om Catalip elementen zijn.

Meestal krijgt niet Catalip als je anders je van plan bent om een ??kind te bezitten verwacht worden, anders wordt je echt een medische moeder. Catalip kan varken uw kind.

Wees voorzichtig, samen met Catalip in het geval u worden getroffen door lever cirrose, hepatitis, ernstige nier - ziekte, galblaas ziekte, diabetes, nier-, lever, hart problemen, hypothyreoidie.

Wees voorzichtig, samen met Catalip in het geval dat u gebruik maakt van dit soort medicijnen, omdat bloedbaan slanker (warfarine (bijvoorbeeld omdat Coumadin)); fluvastatine (bijvoorbeeld omdat Lescol), cholesterolverlagende medicijnen (lovastatine (bijvoorbeeld omdat Mevacor), statines (zoals omdat Zocor), cerivastatin (bijvoorbeeld omdat Baycol), pravastatine (bijvoorbeeld omdat Pravachol), atorvastatine (bijvoorbeeld omdat Lipitor), ciclosporine (zoals omdat Gengraf, Neoral, Sandimmune).

In het geval u slaperigheid en vermoeidheid ondervinden tijdens het gebruik van Catalip je nodig hebt om elke vorm van acties voor bijvoorbeeld reizen of zelfs werkende apparatuur te voorkomen.

voorkomen dat alcoholische dranken.

Senioren moeten voorzichtig zijn, samen met Catalip te zijn.

Maintain cholesterolverlagend evenals vetarm dieet plan.

Meestal niet stoppen met het gebruik van Catalip ineens.

Catalip (Tricor) Veelgestelde vragen

Queen: Precies wat ik moet presteren in principe slaat u de dosering of zelfs een overdosis?

Het volgende: Indien U de dosering die u nodig hebt om het te dragen als je eenmaal in het achterhoofd houden dit over te slaan. Wanneer het tijd is voor de dosering die u nodig hebt om gewoon te dragen op je eigen normale dosering routine. Meestal niet krijgen dual dosering. In het geval u een overdosis Catalip, moet je gewoon controleren of uw arts of zelfs arts instantly. A

Queen: Zeer beste algemene titel in verband met Catalip?

De: General titel geassocieerd met Catalip is eigenlijk Fenofibrate. A

Queen: Dus hoe precies doet Catalip functie?

De: Catalip wordt daadwerkelijk uitvoeren door groeiende chemische stof die niet meer werkt lichaamsvet in de bloedbaan. Het is echt fibraten (cholesterolverlagende middel).A

Queen: Wat is Catalip precies?

De: Catalip kan de geneeskunde van top kwaliteit zijn, dat wordt verbruikt bij het verhelpen van een hogere triglyceride bedragen alsook hartproblemen samen met dieet plan modifications. A

Queen: Very best merk verbonden Catalip?

De: Merken geassocieerd met Catalip neiging om Catalip, Catalip, Antara, Triglide, Lofibra, Lipofen. A zijn

Kopen Catalip (Tricor) online, kopen Catalip (Tricor) online zonder voorschrift, kopen Catalip (Tricor) zonder recept, kopen Catalip (Tricor) goedkoop, kopen Catalip (Tricor) zonder voorschrift, kopen Catalip (Tricor) uit Canada, kopen Catalip (Tricor) Canada, inkopen Catalip (Tricor) online, inkopen Catalip (Tricor) online no prescription, bestelling Catalip (Tricor) zonder recept, Catalip (Tricor) orale pil

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Vent-O-Mat - Products - Rbx Potable Water, Ventomax

VENT-O-MAT SERIES RBX "ANTI SHOCK" AIR RELEASE AND VACUUM BREAK VALVES

The Unique defence against pipe bursts and pipeline system damage!

Vent-O-Mat Series RBX has evolved from a long lineage of research and development into a product that has proven unsurpassed for air release, vacuum protection, surge alleviation and pipeline flow enhancement.

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Vent-O-Mat Series RBX truly represents the pinnacle of valve design evolution. This valve design provides the most comprehensive, effective and efficient pipeline protection relative to initial cost of any other available pipeline component.

Advantages of Vent-O-Mat RBX "Anti-Shock" Air Release & Vacuum Break Valves Are:

Automatic Surge Protection The unique Series RBX valve incorpates as standard, three design features to automatically protect a pipeline, under all pipeline operating conditions, from the destructive surge and water hammer phenomena. These features are independent of any mechanical devices ensuring reaction in a very low milli second time span.

Effective Air Release The RBX design ensures effective de-aeration under all pipeline flow and operating conditions, via either one of three discharge orifices.

Vacuum Protection The RBX series large orifice diameters equal the normal size of the valve. This ensures the least possible resistance to the intake of air and consequently the least possible negative pressure within a draining pipeline.

Guaranteed Performance The RBX has been designed and developed to provide the optimum usable and safe performance relative to all functions. Selection data has been substantiated through third party testing and can therefore be confidently referenced.

VENT-O-MAT Series RBX "Anti-Shock" Air Release and Vacuum Break Valves are available in nominal sizes of DN25 (1") to DN200 (8") and for maximum operating pressures of PN16 (232psi), PN25 (363psi), PN40 (580psi) and PN64 (930psi). Valves are available in all stainless steel 304 or 316 on request.

Delos - Unesco World Heritage Centre, Delos

Delos

Delos

According to Greek mythology, Apollo was born on this tiny island in the Cyclades archipelago. Apollo's sanctuary attracted pilgrims from all over Greece and Delos was a prosperous trading port. The island bears traces of the succeeding civilizations in the Aegean world, from the 3rd millennium B. C. to the palaeochristian era. The archaeological site is exceptionally extensive and rich and conveys the image of a great cosmopolitan Mediterranean port.

Delos

Île minuscule de l'archipel des Cyclades, Délos aurait vu la naissance d'Apollon. Son sanctuaire attirait des pèlerins de toute la Grèce et son port joua un rôle commercial très important. L'île de Délos apporte un témoignage unique sur les civilisations qui se sont succédé dans le monde égéen du III e millénaire av. J.-C. jusqu'à l'époque paléochrétienne. Le site archéologique est exceptionnellement étendu et offre l'image d'un grand port cosmopolite méditerranéen.

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Остров Делос

Согласно греческой мифологии, на этом крошечном острове, входящем в архипелаг Киклады, родился Аполлон. Святилище Аполлона привлекало паломников со всей Греции, и Делос был преуспевающим торговым портом. Остров сохранил следы сменяющих друг друга цивилизаций Эгейского мира с 3-го тысячелетия до н. э. до раннехристианского периода. Археологические памятники Делоса, разнообразные и очень тесно сконцентрированные, формируют образ большого многонационального средиземноморского порта.

Delos

Según la mitología griega, Apolo nació en esta minúscula isla del archipiélago de las Cícladas. Su santuario atraía a peregrinos de toda Grecia y su puerto desempeñó un papel comercial importante. El sitio de Delos aporta un testimonio excepcional sobre las civilizaciones que se sucedieron en el mundo egeo desde el tercer milenio antes de Cristo hasta la época paleocristiana. El sitio arqueológico es sumamente vasto y restituye la imagen de un gran puerto cosmopolita mediterráneo.

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Delos

Volgens de Griekse mythologie werd Apollo geboren op dit kleine eiland in de Cycladen archipel. Apollo’s heiligdom trok pelgrims uit heel Griekenland en Delos was een welvarende handelshaven. Het eiland draagt de sporen van de opeenvolgende beschavingen in de Egeische wereld, van het derde millennium voor Christus tot het paleo-christelijke tijdperk. Gedurende de Grieks-Romeins periode had Delos een aanzienlijke invloed op de ontwikkeling van architectuur en monumentale kunst. Van de 95 hectare archeologisch terrein is 25 hectare blootgelegd. Het gebied is uitzonderlijk uitgebreid en rijk en laat het beeld zien van een grote kosmopolitische mediterrane haven.

Outstanding Universal Value

Delos, even though a small (350.64 ha), rocky island in the centre of the Aegean Sea, was considered as “the most sacred of all islands” (Callimachus, 3rd century BC) in ancient Greek culture. According to the legend, it was there that Apollo-Sun, god of daylight, and his twin sister Artemis-Moon, goddess of night light, were born.

The island was first settled in the third millennium BC. The Apollonian sanctuary, established at least since the 9th century BC, reached the peak of its glory during the Archaic and Classical period, when it acquired its Pan-Hellenic character. After 167 BC, as a result of the declaration of Delos as a free port, all the commercial activity of the eastern Mediterranean was concentrated on the isle. Rich merchants, bankers and ship-owners from all over the world settled there, attracting many builders, artists and craftsmen, who built for them luxurious houses, richly decorated with frescoes and mosaic floors. The small island became soon the maximum emporium totius orbis terrarium (S. P. Festus, 2nd century AD) – the greatest commercial centre of the whole world. The prosperity of the island and the friendly relations with the Romans were the main cause of its destruction. Delos was attacked and looted twice: in 88 BC by Mithridates, the King of Pontus, an enemy of the Romans, and later, in 69 BC, by the pirates of Athenodorus, an ally of Mithridates. Since then, the island fell rapidly into decline and was gradually abandoned. Captured after its abandonment successively by the Byzantines, Slavs, Saracens, the Venetians, the Knights of St. John and the Ottomans, Delos was turned into a quarry site with its temple columns burnt for lime, and its houses left in ruins.

The excavations that started in 1872 and are still in progress have unearthed the Sanctuary and a good part of the cosmopolitan Hellenistic town. The monuments that have been excavated up to now speak most eloquently for the grandeur of the sacred island and illuminate a past civilisation, which was Europe's cradle and wet nurse. The entire island is an archaeological site, which, along with the neighbouring islands of Rheneia, Greater and Lesser Rematiaris, constitutes an immense archaeological site.

Criterion (ii): Delos had considerable influence on the development of architecture and monumental arts during the Greco-Roman period, as seen in the immense Hellenistic sanctuary. A great part of its treasure of masterpieces was found during the excavations and is exhibited today in Delos’ Museum. This influence was matched later by the important role it has played since the 15th century in furthering our knowledge of ancient Greek art from a widely renowned site , which is among the first sites in Greece that captured the attention of archaeologists and travellers.

Criterion (iii): The island of Delos bears unique witness to the civilizations of the Aegean world since the 3rd millennium BC. During the Palaeo-Christian era, it was the seat of the bishopric of the Cyclades. From the 7th century BC to the pillage by Athenodoros in 69 BC, the island of Delos was one of the principal Pan-Hellenic sanctuaries. The feast of the Delians, which was celebrated every four years in the month of May until 316 BC, included gymnastic, equestrian and musical competitions, Archaic Age dances, theatrical productions and banquets. Like the Olympic and the Pythic Games, it was one of the major events in the Greek world.

Criterion (iv): The archaeological site of Delos provides an outstanding example of an architectural ensemble that restores the image of an extremely important cosmopolitan Mediterranean port that began to prosper since 314 BC, reaching outstanding levels during the 2nd and 1st centuries BC. Warehouses and trading companies abounded, large residential areas were established, public buildings were founded by associations of bankers, traders and ship-owners. Moreover, there were an unprecedented number of sanctuaries dedicated to foreign religions: temples of Sarapis, Isis and Anubis, temples to the Syrian gods Haadad and Atargatis, and even a synagogue in the stadium district.

Criterion (vi) : Delos is directly and tangibly associated with one of the principal myths of Hellenic civilisation. It was on this arid islet that Leto, made pregnant by Zeus and fleeing the vengeance of Hera, gave birth to Apollo and Artemis after a difficult labour. According to a Homeric hymn, the island, which until then had been floating, became anchored to the floor of the ocean. The newborn Phoebus - Apollo threw off his swaddling clothes bathed the universe in light and began walking with his cither and his bow. Kynthos, the mountain of Zeus, and the wheel-shaped lake, close to which the pregnant Leto suffered labor pains for nine days and nights, remain essential landmarks of the island's sacred geography, which was clearly defined by the additions made to the Delian sanctuary to Apollo between the 6th and the 1st centuries BC.

Delos was preserved through the centuries due to the fact that it remained uninhabited since the 7th century AD and due to its remote location. Nowadays, the entire island is designated as an archaeological site. The Hellenic Ministry of Culture, Education and Religious Affairs monitors the condition of the monuments and constantly provides for their protection, conservation, support and presentation. Therefore, the property not only maintains its integrity but also, through continuous works catering for its preservation, it constantly enhances and highlights the values for which it was designated a World Heritage site. Among the major factors that affect the monuments of Delos are the strong north winds that dominate the central Aegean region and its proximity to the sea. The property receives over 100,000 visitors annually and any risks to the fragile landscape are mitigated.

The authenticity of the site has not been challenged. The restoration work aims mostly to the preservation of the monuments in the state they were found during the excavations, while the methods and materials employed are compatible, discrete and reversible, in accordance to international standards. Therefore, there are no changes in the authentic character of the site during the last 130 years.

The landscape also remains unaltered; not a village or a town was ever built over the ancient ruins. The only modern constructions on the island are the Museum, the refectory and a few small houses for the personnel, which were necessary for the functioning of the property as an archaeological site.

Protection and management requirements

The entire island of Delos is an archaeological site, protected under the provisions of Law 3028/2002 “ On the Protection of Antiquities and Cultural Heritage in general ”. The Ministry of Culture, Education and Religious Affairs is the competent body supervising the site and overseeing all works carried out. The Ephorate of Antiquities of Cyclades, the competent Regional Service of the Ministry, is responsible for its management and protection. All the works carried out in the archaeological site are supervised by the Committee for the Conservation of the Monuments of Delos, a scientific body that plans, supervises and executes work programmes for the conservation, support and restoration of the monuments, as well as for the presentation and protection of the property.

Because of potential damage by the north wind, fragile marble sculptures, such as the Naxian Lions, were transported to the Museum and have been replaced with exact replicas. Moreover, research has been undertaken to investigate the structural materials of the ancient monuments, their origin and pathology. There are also ongoing studies for the overall conservation, support and presentation of the specific monuments.

Many projects have been implemented on the vast archaeological site of Delos in recent years, with funding from the European Union and the Greek State. The aim of the works has been the conservation and consolidation of the monuments and the creation of visitors’ pathways, thus ensuring access to the entire archaeological site, especially for people with disabilities. Moreover, the works aspired to make the visit to the site truly instructive, meaningful and, of course, safe for monuments and visitors alike.

Despite the major practical difficulties stemming from its remote location, which greatly exacerbates the conditions for the implementation of any kind of works, antiquity guards, archaeologists, conservators, architects and technicians reside on the island throughout the year carrying out important conservation, restoration and site-presentation work, gradually rendering the site accessible, more “legible”, comprehensible and friendly to the numerous visitors. However, renovation and refurbishment of the museum is deemed necessary in order to enhance visitors’ experience.

Any risks to the fragile landscape and the ancient monuments that might arise by the increasing number of visitors are mitigated by the designation of specific itineraries and by the employment of temporary personnel during the high tourist season.

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Venlalic Xl (Venlafaxine) Report For Patients Like You, Venlalic

Venlalic XL treatment report

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What is venlafaxine?

Venlafaxine is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Venlafaxine affects chemicals in the brain that may become unbalanced and cause depression.

Venlafaxine is used to treat major depressive disorder, anxiety, and panic disorder.

Venlafaxine may also be used for other purposes not listed in this medication guide.

Precautions

Do not take this medication if you are allergic to venlafaxine, or if you are also using a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate). You must wait at least 14 days after stopping an MAOI before you can take venlafaxine. After you stop taking venlafaxine, you must wait at least 7 days before you start taking an MAOI.

Before taking venlafaxine, tell your doctor if you are allergic to any medications, or if you have:

bipolar disorder (manic depression);

cirrhosis or other liver disease;

kidney disease;

high blood pressure;

glaucoma;

seizures or epilepsy;

a bleeding or blood clotting disorder; or

high cholesterol.

If you have any of the conditions listed above, you may need a dose adjustment or special test to safely take venlafaxine.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. Venlafaxine may be harmful to an unborn baby, and may cause problems in a newborn baby if the mother takes the medication late in pregnancy (during the third trimester). Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Venlafaxine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medication to anyone under 18 years old without the advice of a doctor.

Avoid drinking alcohol, which can increase some of the side effects of venlafaxine.

Venlafaxine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Tell your doctor if you regularly use other drugs that can cause sleepiness (such as cold or allergy medicine, narcotic pain medication, sedatives, muscle relaxers, or medicines to treat seizures or anxiety). These may add to sleepiness caused by venlafaxine.

Instructions

Seek emergency medical attention if you think you have taken too much of this medication.

Overdose symptoms may include dizziness, sleepiness, nausea, and numbness or tingling in your hands or feet.

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Contact your doctor promptly if you have any of the following side effects, especially if they are new symptoms or if they get worse: mood changes, anxiety, panic attacks, trouble sleeping, irritability, agitation, aggressiveness, severe restlessness, mania (mental and/or physical hyperactivity), thoughts of suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

increased blood pressure (severe headache, blurred vision);

easy bruising or bleeding;

severe blistering, peeling, and red skin rash;

very stiff (rigid) muscles, high fever, sweating, fast or uneven heartbeats, tremors, overactive reflexes;

nausea, vomiting, diarrhea, loss of appetite, feeling unsteady, loss of coordination; or

headache, trouble concentrating, memory problems, weakness, confusion, hallucinations, fainting, seizure, shallow breathing or breathing that stops.

Less serious side effects may include:

drowsiness, dizziness, feeling nervous;

dry mouth;

mild nausea, constipation;

decreased sex drive, impotence, or difficulty having an orgasm;

blurred vision;

increased appetite; or

changes in weight.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Interactions

Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with venlafaxine may cause you to bruise or bleed easily.

Before taking venlafaxine, tell your doctor if you are using any of the following medicines:

cimetidine (Tagamet, Tagamet HB);

warfarin (Coumadin);

ketoconazole (Nizoral);

tryptophan (sometimes called L-tryptophan);

haloperidol (Haldol) or risperidone (Risperdal);

almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig); or

any other antidepressants such as amitriptyline (Elavil), amoxapine (Ascendin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), or trimipramine (Surmontil).

This list is not complete and there may be other drugs that can interact with venlafaxine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

Effexor, Effexor XR, and venlafaxine

Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

Last updated: September 21, 2016

What is the most important information I should know about venlafaxine?

Do not take this medication if you are allergic to venlafaxine, or if you are also using a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Avoid drinking alcohol, which can increase some of the side effects of venlafaxine.

It may take 4 weeks or more for your symptoms to improve. For best results, keep using the medication as directed. Do not stop using venlafaxine without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly.

Warning

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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The company’s main focus is on the integrated supply chain solutions of electronic and electrical components used in the design, production and maintenance of electronic equipment for consumer use. Our range of products lists more than 2 million unique part numbers from more than 1300 manufacturers of electronic and electrical components. We are positioned as resellers and direct distributors of the components manufacturers from USA, Europe and Japan, which ensures the highest quality of OEM original parts and sku numbers. Our market distribution network is based on the B2B model as a wholesale provider of components for the industrial enterprise and retail chains, service centers and hams. We strive to maintain our ISO certification and our quality management system was ISO certified 9001 in 2012.

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The company's mission is to provide access for Russian industrial enterprise and Russian based companies, research organizations and engineers with the advanced technological components. In its operations, the company adheres to the principles of the Anti-Corruption policy of strict compliance with Russian legislation and the legislation of the European Union and the United States on non-proliferation of weapons of mass destruction and to control the export of sensitive technologies. In this regard, the company Elitan - does not export (sells outside the Russian Federation) components.

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Hipertil Indication, Action Of Hipertil, Interactions, Hipertil

Hipertil [in more detail]

For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.

Hipertil Mechanism Of Action:

Hipertil competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II levels results in a decrease in blood pressure, an increase in renin activity, and stimulation of baroreceptor reflex mechanisms. Kininase II, an enzyme which degrades the vasodilator bradykinin, is identical to ACE and may also be inhibited.

Hipertil Drug Interactions:

Amiloride Increased risk of hyperkaliemia Drospirenone Increased risk of hyperkaliemia Lithium The ACE inhibitor increases serum levels of lithium Potassium Increased risk of hyperkaliemia Spironolactone Increased risk of hyperkaliemia Tizanidine Tizanidine increases the risk of hypotension with the ACE inhibitor Triamterene Increased risk of hyperkaliemia

Food Interactions:

Avoid alcohol. Avoid salt substitutes containing potassium. Take on empty stomach: 1 hour before or 2 hours after meals, food decreases absorption by 30 to 55%. Avoid natural licorice. Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.

Hipertil Chemical Formula:

Dermabet, Dermabet

betamethasone

betamethasone

a synthetic glucocorticoid. the most active of the steroid antiinflammatory agents; used topically as the benzoate, dipropionate, or valerate salts as an antiinflammatory, topically or rectally as the sodium phosphate salt as an antiinflammatory, and systemically as the base or the combination of sodium phosphate and acetate salts as an antiinflammatory, as a replacement for adrenal insufficiency, and as an immunosuppressant.

betamethasone

/be·ta·meth·a·sone/ ( ba″tah-meth?ah-sōn ) a synthetic glucocorticoid, the most active of the antiinflammatory steroids; used topically as the benzoate, dipropionate, or valerate salts as an antiinflammatory, topically or rectally as the sodium phosphate salt as an antiinflammatory, and systemically as the base or the combination of sodium phosphate and acetate salts as an antiinflammatory, as a replacement for adrenal insufficiency, and as an immunosuppressant.

betamethasone

A synthetic glucocorticoid, C 22 H 29 FO 5 . that occurs as a white crystalline powder and is used as a topical anti-inflammatory agent for the treatment of dermatological conditions.

betamethasone

indication It is prescribed for topical corticosteroid-responsive dermatoses and injected directly into lesions (bursitis, rheumatoid arthritis, etc.) to help control pain and inflammation.

contraindications Systemic fungal infections, dermatological viral and fungal infections, impaired circulation, or known hypersensitivity to this drug prohibits its use.

adverse effects Among the more serious adverse reactions associated with prolonged use of the drug are GI, endocrine, neurological, and fluid and electrolyte disturbances.

betamethasone

A corticosteroid drug used directly on the skin to treat ECZEMA and PSORIASIS. by inhalation to treat ASTHMA. by mouth for more severe allergic conditions and by injection to reduce brain swelling in head injuries, tumour and infections. The drug is on the WHO official list. Brand names are Betnelan, Betnesol, Betnovate, Bettamousse and Vista-Methasone.

betamethasone

semisynthetic glucocorticoid with anti-inflammatory and toxic effects, similar to cortisol; more potent than prednisolone

betamethasone (valerate, betamethasone benzoate, betamethasone dipropionate) (bā´təmeth´əsōn) ,

n brand names: Uticort, Beben, and others; drug class: topical corticosteroid; action: interacts with steroid cytoplasmic receptors to induce antiinflammatory effects; possesses antipruritic, antiinflammatory actions; uses: treatment of psoriasis, eczema, contact dermatitis, pruritus, and oral ulcerative inflammatory lesions.

betamethasone

a long-acting synthetic glucocorticoid, used as an anti-inflammatory.

Link to this page:

DermaBond

References in periodicals archive ?

7 x 30 mm] Insyte[TM] Autoguard[TM] [BD, Franklin Lakes, NJ, USA], made of BD Vialon), with two cyanoacrylate TAs: Dermabond and Histoacryl, and three removal agents: paraffin, acetone and Remove[TM] adhesive removal wipes (Smith & Nephew, Canada) was assessed by measuring the tensile strength of IVCs after exposure to these solutions on the central 1 cm of the IVC for one hour, followed by mechanical testing.

Furthermore, these findings are of particular significance to specialists, as they show that DERMABOND Adhesive can be successfully utilized and achieve a high rate of satisfaction among both physicians and patients across numerous surgical applications.

Dermabond is likely to become standard equipment in the offices of pediatricians and dermatologists, as well as in emergency departments.

tissue cohesive products include DERMABOND Topical Skin Adhesive, which is used to replace sutures and staples for closure of certain lacerations and incisions, OCTYLDENT cohesive, which is used as an adjunct in the treatment of adult periodontal disease; and NEXABAND topical cohesives, a family of products used in veterinary wound closure and management.

CLOSURE Medical filed the pre-market approval application (PMA) with the FDA in December 1996 whereupon the application was granted "expedited processing" because of the potential public health benefit of DERMABOND Topical Skin Adhesive to reduce patient pain and anxiety.

Wound closure includes the world's largest portfolio of synthetic sutures, PLUS Coated Antibacterial sutures and Dermabond Topical Skin Adhesive.

With innovative technologies such as DERMABOND Topical Skin Adhesive, Plus Antibacterial Sutures and FlexHD Acellular Hydrated Dermis, Ethicon is focused on the specific needs of the nurse, patient and hospital.

NEW YORK -- Dermabond adhesive is significantly faster than sutures for trocar incision closure and comparable in terms of pain and cosmesis in gynecologic surgery, Marlan Schwartz, M.

Clark spearheaded the company's efforts to develop manufacturing and packaging processes for medical-grade adhesives; continued research eventually led to the success of Dermabond Topical Skin Adhesive, currently the company's main product, the first, and so far only, cyanoacrylate medical product to receive approval from the U.

Manufactured as Dermabond by Ethicon, a major American producer of conventional suture material, this new adhesive was used in 130 patients with 136 total lacerations admitted to the emergency department of the Ottawa General Hospital in Ontario, Canada.

High Viscosity Dermabond Topical Skin Adhesive (2-octyl cyanoacrylate) is approved as a topical application to hold closed easily approximated skin edges of wounds from surgical incisions, including punctures from minimally invasive surgery and simple, thoroughly cleansed, trauma-induced lacerations.

DERMABOND adhesive should not be used on patients with a known hypersensitivity to cyanoacrylate or formaldehyde.

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Ranitidine (Raniloc)

Ranitidine is used for treating certain conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It is also used to treat ulcers of the small intestine that have not responded to other treatment. It may be used as a short-term alternative to oral ranitidine, in patients who are not able to take medicine by mouth. Ranitidine is an H 2 - receptor blocker. It works by blocking the action of histamine in the stomach. This reduces the amount of acid the stomach makes. Reducing stomach acid helps to reduce heartburn, heal irritation of the esophagus, and heal ulcers of the stomach or intestines.

Use Ranitidine as directed by your doctor.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

You may take antacids while you are using Ranitidine if you are directed to do so by your doctor.

Continue to use Ranitidine even if you feel well. Do not miss any dose.

If you miss a dose of Ranitidine, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ranitidine.

Store Ranitidine between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ranitidine out of the reach of children and away from pets.

Do NOT use Ranitidine if:

you are allergic to any ingredient in Ranitidine

you have a history of the blood disease porphyria

you are taking dasatinib.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Ranitidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems

if you have abnormal blood electrolyte levels or a history of irregular heartbeat.

Some medicines may interact with Ranitidine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Certain benzodiazepines (eg, midazolam, triazolam), glipizide, procainamide, or warfarin because the risk of their side effects may be increased by Ranitidine

Dasatinib, delavirdine, gefitinib, certain HIV protease inhibitors (eg, atazanavir), itraconazole, or ketoconazole because their effectiveness may be decreased by Ranitidine.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ranitidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Ranitidine may rarely cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ranitidine with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Ranitidine may interfere with certain lab tests, including urine protein tests. Be sure your doctor and lab personnel know you are taking Ranitidine.

Lab tests, including liver function, may be performed while you use Ranitidine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Ranitidine should be used with extreme caution in children younger than 1 month old; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ranitidine while you are pregnant. Ranitidine is found in breast milk. Do not breastfeed while taking Ranitidine.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; headache; nausea; stomach upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); change in the amount of urine produced; confusion; dark urine; depression; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; severe or persistent headache or stomach pain; unusual bruising or bleeding; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Allergic states. severe allergic. urticaria. anaphylactic choke.

Dermatologic diseases. pemphingus. lichen. severe psoriasis, mycosis fungoids severe erythema multiform.

Hematologic disorders. idiopathic thrombocytopenic purpurea. acquired ( autoimmune )hemolytic anemia. erythroblastopenia (RBC anemia).

Endocrine disorders. congenital adrenal hyperplasia. nonsuppurative thyroidistis. hypercalcemia associated with cancer.

Ophthalmic disease. allergic conjunctivitis. ceratitis. iritis and iridocyclitis, optic neuritis.

Respiratory disease. symptomatic sarcoidosis. cases of obstructive broncho pneum. pathe. some cases of asthma.

Rheumatic disorders. rheumatoid arthritis. acute and subacute bursitis. ankylosing spondylitis.

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Albendazole (Krimizole)

Albendazole is used for treating certain tapeworm infections. Albendazole is an anthelmintic. It works by killing sensitive parasites.

Use Albendazole as directed by your doctor.

Take Albendazole by mouth with food.

If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water.

If you miss a dose of Albendazole, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your doctor or pharmacist.

Ask your health care provider any question you may have about how to use Albendazole.

Store Albendazole at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Albendazole out of the reach of children and away from pets.

Do NOT use Albendazole if:

you are allergic to any ingredient in Albendazole or to benzimidazoles (eg, rabeprazole).

Some medical conditions may interact with Albendazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have liver problems, eye problems (eg, retinal lesions), bone marrow problems, low white blood cell counts, or low platelet counts.

Some medicines may interact with Albendazole. Tell your health care provider if you are taking any other medicines, especially any of the following:

Cimetidine, dexamethasone, or praziquantel because they may increase the risk of Albendazole's side effects

Theophylline because the risk of its side effects may be increased by Albendazole.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Albendazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Albendazole may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Albendazole with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Albendazole may rarely lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you are a woman who may become pregnant, you should have a negative pregnancy test before you start taking Albendazole. You must use an effective form of birth control while you take Albendazole and for at least 1 month after you stop taking it.

Lab tests, including complete blood cell counts and liver function, may be performed while you use Albendazole. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Albendazole should be used with extreme caution in children younger than 1 year old; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: Do not use Albendazole if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it and for at least 1 month after you stop taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Albendazole is found in breast milk. If you are or will be breast-feeding while you use Albendazole, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Headache; nausea; stomach pain; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; decreased urination; fever, chills, or sore throat; red, swollen, peeling, or blistered skin; seizures; severe or persistent dizziness or headache; unusual bruising or bleeding; unusual tiredness or weakness; vision changes; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Albendazole (Krimizole)

Albendazole is used for treating certain tapeworm infections. Albendazole is an anthelmintic. It works by killing sensitive parasites.

Use Albendazole as directed by your doctor.

Take Albendazole by mouth with food.

If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water.

If you miss a dose of Albendazole, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your doctor or pharmacist.

Ask your health care provider any question you may have about how to use Albendazole.

Store Albendazole at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Albendazole out of the reach of children and away from pets.

Do NOT use Albendazole if:

you are allergic to any ingredient in Albendazole or to benzimidazoles (eg, rabeprazole).

Some medical conditions may interact with Albendazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have liver problems, eye problems (eg, retinal lesions), bone marrow problems, low white blood cell counts, or low platelet counts.

Some medicines may interact with Albendazole. Tell your health care provider if you are taking any other medicines, especially any of the following:

Cimetidine, dexamethasone, or praziquantel because they may increase the risk of Albendazole's side effects

Theophylline because the risk of its side effects may be increased by Albendazole.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Albendazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Albendazole may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Albendazole with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Albendazole may rarely lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you are a woman who may become pregnant, you should have a negative pregnancy test before you start taking Albendazole. You must use an effective form of birth control while you take Albendazole and for at least 1 month after you stop taking it.

Lab tests, including complete blood cell counts and liver function, may be performed while you use Albendazole. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Albendazole should be used with extreme caution in children younger than 1 year old; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: Do not use Albendazole if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it and for at least 1 month after you stop taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Albendazole is found in breast milk. If you are or will be breast-feeding while you use Albendazole, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Headache; nausea; stomach pain; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; decreased urination; fever, chills, or sore throat; red, swollen, peeling, or blistered skin; seizures; severe or persistent dizziness or headache; unusual bruising or bleeding; unusual tiredness or weakness; vision changes; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Ketorolaco

El ketorolaco se usa para el alivio a corto plazo del dolor moderadamente intenso y no debe usarse por mas tiempo que 5 dias, para condiciones que causen dolor leve, o dolor cronico (a largo plazo). Usted recibira sus primeras dosis de ketorolaco por via intravenosa (en una vena) o inyeccion intramuscular (en un musculo) en un hospital o en un consultorio medico. Despues de eso, su doctor puede decidir seguir su tratamiento con ketorolaco oral. Usted debe dejar de tomar ketorolaco oral al quinto dia despues de recibir su primera inyeccion. Digale a su doctor si tiodavia siente dolor despues de 5 dias o si el dolor no ha sido controlado por este medicamento. El ketorolaco puede causar efectos secundarios graves, especialmente cuando se toma en forma inapropiada. Tome el ketorolaco exactamente como se indica. No use mas ni menos que la dosis indicada ni tampoco mas seguido que lo prescrito por su doctor.

Las personas que toman medicamentos antiinflamatorios sin esteroides (NSAIDs, por sus siglas en ingles; diferentes a la aspirina) como el ketorolaco pueden tener mayor riesgo de tener un ataque cardiaco o un accidente cerebrovascular, que las personas que no toman estos medicamentos. Estos casos podrian ocurrir de forma imprevista y hasta causar la muerte. Este riesgo puede aumentar en las personas que toman estos medicamentos durante mucho tiempo. No use un NSAID como ketorolaco si sufrio un ataque cardiaco recientemente, a menos que se lo indique su medico. Digale a su doctor si usted o alguien en su familia tiene o alguna vez ha tenido enfermedades al corazon, un ataque cardiaco, o un accidente cerebrovascular, o miniaccidente cerebrovascular, si fuma, y si usted tiene o alguna vez han tenido colesterol alto, hipertension (alta presion arterial), sangrando o problemas con la coalgulacion, o diabetes. Obtenga ayuda medica de emergencia en forma inmediata si experimenta cualquiera de los siguientes sintomas: dolor en el pecho, dificultad para respirar, debilidad en una parte o un lado del cuerpo, o dificultad para hablar.

Si va a ser sometido a cualquier cirugia, incluyendo la dental, digale al doctor o dentista que usted esta tomando ketorolaco. Si va a ser sometido a una operacion en las arterias coronarias (CABG, por su sigla en ingles; un tipo de operacion quirurgica del corazon), no tome ketorolaco antes ni despues de la operacion quirurgica.

Los antiinflamatorios sin esteroides como el ketorolaco pueden causar ulceras, hemorragias, o perforaciones en el estomago o el intestino. Estos problemas pueden desarrollarse en cualquier momento durante el tratamiento, presentarse sin sintomas previos y causar la muerte. El riesgo podria ser mayor en las personas que toman antiinflamatorios sin esteroides durante mucho tiempo, las personas mayores, aquellos que no tienen buena salud o en quienes toman mas de tres bebidas alcoholicas por dia mientras toman este medicamento. Digale a su doctor si esta tomando cualquiera de los siguientes medicamentos: anticoagulantes como la warfarina (Cumadina, Jantoven); aspirina; esteroides orales como la dexametasona, metilprednisolona (Medrol), y prednisona (Rayos); inhibidores selectivos de recaptacion de serotonina (SSRIs, por sus siglas en ingles) como citalopram (Celexa), fluoxetina (Prozac, Sarafem, Selfemra, en Symbyax), fluvoxamina (Luvox), paroxetina (Brisdelle, Paxil, Pexeva), y sertralina (Zoloft); o inhibidores de la recaptacion de serotonina/norepinefrina (SNRIs, por sus siglas en ingles) como desvenlafaxina (Khedezla, Pristiq), duloxetina (Cymbalta), y venlafaxina (Effexor XR). No tome aspirinas u otros antiinflamatorios sin esteroides como ibuprofeno (Advil, Motrin) y naproxeno (Aleve, Naprosyn) mientras esta tomando ketorolaco. Tambien digale a su doctor si tiene o alguna vez ha tenido ulceras o hemorragias en el estomago o los intestinos. Si usted experimenta cualquiera de los siguientes sintomas, deje de tomar ketorolaco y llame a su doctor: dolor de estomago, pirosis (acidez estomacal), vomitando una sustancia eso es sangrienta o se parece a los terrenos de cafe, sangre en las heces, o heces oscuras o alquitranadas (de color petroleo).

El ketorolaco puede causar insuficiencia renal. Digale a su doctor su tiene enfermedades al rinon o al higado, si ha tenido vomitos o diarrea grave o si piensa que puede estar deshidratado y si esta tomando inhibidores de la enzima conversora de la angiotensina (ECA) como benazepril (Lotensin; en Lotrel), captopril, enalapril (Vasotec, en Vaseretic), fosinopril, lisinopril (en Zestoretic), moexipril (Univasc), perindopril (Aceon, en Prestalia), quinapril (Accupril, en Quinaretic), ramipril (Altace), y trandolapril (Mavik, en Tarka); o diureticos ("pildoras de agua"). Si usted experimenta cualquiera de los siguientes sintomas, deje de tomar ketorolaco y llame a su doctor: hinchazon de las manos, brazos, pies, tobillos o las pantorrillas; aumento de peso inexplicable; confusion; o crisis convulsivas.

Algunas personas tienen reacciones alergicas graves al ketorolaco. Digale a su doctor si usted es alergico al ketorolaco, la aspirina u otros antiinflamatorios sin esteroides como el ibuprofeno (Advil, Motrin) o el naproxeno (Aleve, Naprosyn), o a otros medicamentos. Tambien digale a su doctor si tiene o alguna vez ha tenido asma, especialmente si frecuentemente tiene congestion o secrecion nasal o polipos nasales (hinchazon del recubrimiento de la nariz). Si usted experimenta cualquiera de los siguientes sintomas, deje de tomar ketorolaco y llame de inmediato a su doctor: sarpullido (erupciones en la piel); urticarias; acompanado de prurito (picazon); hinchazon de los ojos, cara, garganta, lengua, brazos, manos, tobillos, o las pantorrillas; dificultad para respirar o tragar; o ronquera.

No amamante mientras esta tomando ketorolaco.

Cumpla con todas las citas con su doctor y el laboratorio. Su doctor ordenara ciertas pruebas de laboratorio que comprueben la respuesta de su cuerpo al ketorolaco. Asegurese de decirle a su doctor como se siente, para que pueda prescribirle la cantidad correcta de medicamento y asi tratar su condicion con el riesgo mas bajo que ocurran efectos secundarios graves.

Su doctor o farmaceutico le dara la hoja de informacion del fabricante para el paciente (guia del medicamento) cuando usted empieza el tratamiento con ketorolaco y siempre que usted renueva su prescripcion. Lea la informacion cuidadosamente y preguntele cualquier cosa que no entienda. Usted tambien puede obtener la guia del medicamento del sitio Web de la Administracion de Alimentos y Medicamentos (FDA, por su sigla en ingles): http://www. fda. gov/Drugs/DrugSafety/ucm085729.htm o del sitio Web del fabricante.

?Para cuales condiciones o enfermedades se prescribe este medicamento?

Author Ladylen, Ladylen

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Shaman King, K+, Spanish, Romance, chapters: 4, words: 11k+, favs: 6, follows: 2, updated: 3/27/2007 published: 9/20/2006. Ren T. Horohoro U.

Shaman King, K+, English, Humor, words: 1k+, favs: 9, follows: 1, 7/24/2006. Ryu U. Ren T.

34 Windows to the soul » by supagal First fic please don't flame! Yoh's in love but not with Anna. And why is Anna so drawn to the boy with golden eyes? And who exactly is Hao wanting to claim as his? Can't write summary's! YxT RxA HxR

Shaman King, T, English, Romance, chapters: 9, words: 10k+, favs: 11, follows: 6, updated: 7/12/2006 published: 3/20/2005

25 Captured then Saved » by Kuroi Enkou HaoHoroHoroRen pairing, Yoh's group come out of the Tome of the Shaman and are confronted by the Xlaws. They fight and it ends in a tie, but HoroHoro is captured. Who'll save him? and what's this Marco is in lust with him? What'll happen? RR to find out.

Shaman King, M, English, Angst & Romance, chapters: 7, words: 8k+, favs: 7, follows: 9, updated: 7/9/2006 published: 1/26/2006. Horohoro U. Hao A.

12 The Aftermath by yugioh-fan88 Sequel to "Join me". Ren joined Hao's team and sees that things would now be quite interesting. Yaoi! HaoRen R&R!

Shaman King, M, English, Romance & Humor, words: 1k+, favs: 6, follows: 10, 2/9/2006

11 Join me by yugioh-fan88 Oneshot! Hao approaches Ren outside Patch Village, asking him to join him again. This time he won't take no for an answer. YAOI! HaoRen R&R! COMPLETE!

Shaman King, M, English, Romance, words: 3k+, favs: 10, follows: 2, 2/8/2006

102 SHAMAN 12 » by Ann Saotomo EL PROBLEMA NO PARECE QUERE ACABAR, Y AHORA HAO EFECTUARA SU ULTIMA MANIOBRA. HOROXREN, YHOXANNA, ADVERTENCIA DE LEMMON HOROXREN ?CAP 18 ARRIBA n0n! FIC TERMINADO

Shaman King, K, Spanish, Humor & Adventure, chapters: 18, words: 97k+, favs: 27, follows: 2, updated: 1/15/2006 published: 12/18/2003. [Horohoro U. Ren T.]

29 Finding Love » by Lady Gaidin Hao kidnaps Ren and Yoh will do anything to get him back. Could it be love? After spending time with his captive Hao begins to develope feelings for Ren and when Yoh arrives he may not be willing to give Ren up. Shounen ai. Complete. Please R&R

Shaman King, T, English, Romance, chapters: 6, words: 12k+, favs: 49, follows: 6, 12/4/2005. Yoh A. Ren T.

57 True confessions and hidden lies » by SaturnMax This is a YohRen, HoroRen story. Horo and Yoh try to tell Ren how they feel towards him but he wont tell them how he feels towards them. When Horo starts feeling weird another person is involved. And Why does Hao become involved? I suck at summeries.

Shaman King, T, English, Romance, chapters: 8, words: 19k+, favs: 16, follows: 10, updated: 9/4/2005 published: 4/8/2005

Shaman King, K+, English, Romance & Humor, words: 1k+, favs: 2, follows: 1, 7/17/2005

45 You'll Choke On Those Words » by Dengon Mitsukai Ren's drunken actions end up wounding a relationship he held dear to his heart, and now he's lost Horokeu. Can he figure out what he did and pick up the pieces? RenHoroRen ShounenAi. Chapter Four Up Hao's in town.

Shaman King, T, English, Suspense & Romance, chapters: 4, words: 6k+, favs: 5, follows: 6, updated: 6/15/2005 published: 5/8/2005

19 In My Dreams by unicorn13564 Yaoi. One-shot. Ren gets suspicious when Hao starts to act a little odd around him, being nice to him, helping, but most of the time he is constantly bugging him. What could be the cause of Hao's actions? Ren is about to find out.

Shaman King, K+, English, Humor & Romance, words: 2k+, favs: 12, 3/20/2005

121 Enferecole » by limpet666 Hellschool for the frenchically challenged Yoh and Ren move to Paris to get some 'alone time'. Yoh signs up for a French school and ultimately drags Ren along for the ride. Chp 9 done! Meeble! Ren x Yoh Yaoi!

Shaman King, M, English, Romance & Angst, chapters: 9, words: 14k+, favs: 20, follows: 4, updated: 3/4/2005 published: 8/19/2004. Ren T. Yoh A.

Shaman King, T, Spanish, Drama & Romance, words: 820, favs: 2, 1/4/2004

Leukase N Kegel Zakazat Lekarstva Iz Germanii, Poisk Lekarstva Germaniya, Kupit Lekarstva, Poisk Lek

Поиск лекарства Германия по немецкой аптечной базе

Как правильно работать с поиском:

1. В строку поиска необходимо вписывать название лекарств медикаментов латинскими буквами или номер ( PZN ) например: 78597. 2. Если лекарство медикамент который Вы ищите искал кто то до вас то наша система поиска автоматически предложит Вам различные варианты. которые Вы можете выбрать из появившегося списка. 3. Так же для более удобного поиска Вы можете пользоваться "сортировкой" по названию . цене и производителю медикамента который Вы ищите.

Если Вы ничего не нашли отправьте нам свой запрос через форму заказа лекарства .

Buy Cheap Allergies - Nor Fexodina (Brand Name Allegra) (Fexofenadine) Buy Allergies - Nor Fexodina

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: kidney disease an unusual or allergic reaction to fexofenadine, terfenadine, other medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. You may take this medicine with food or on an empty stomach. Take your medicine at regular intervals. Do not take it more often than directed. You may need to take this medicine for several days before your symptoms improve.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years old for selected conditions, precautions do apply.

If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine? antacids erythromycin grapefruit, apple, or orange juice ketoconazole magnesium-containing products

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine. What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your health. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue breathing problems chest pain fast heartbeat infection or fever

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): cough drowsiness dry or irritated nose, mouth, or throat headache menstrual changes pain stomach upset, nausea

This list may not describe all possible side effects. Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77degrees F). Protect from moisture. Throw away any unused medicine after the expiration date.

Budes Erfahrungen, Bewertungen Und Nebenwirkungen, Budes

Budes

Beschreibung der unerwunschten Nebenwirkung:

Aufgrund meines Horsturzes musste ich obige Medikamente nehmen. Im Laufe der Zeit traten folgende Sachen auf: Zittrigkeit der Hande, Ohrensausen als ob der Kopf in Watte gehullt ist, geschwollene Beine und Hande abends, Nachtschwei?, tagsuber zittern vor Kalte, allgemeines Unruhe - gefuhl wie unter Starkstrom. Als ich zum Schluss auch noch ein Gefuhl in der Brust bekam, als ob ein Eisenring drum liegt, kaum Luft bekommen habe, setzte ich die Trental seit 2 Tagen ab. Beim Prednihexal bin ich beim rausschleichen. Aber die Luftenge habe ich immer noch und alle anderen Beschwerden auch noch. Inwieweit eine Wechselwirkung mit meinen anderen Medikamenten besteht, kann ich nicht sagen.

Eingetragen am 11.01.2009 als Datensatz 12468

Die Nebenwirkungen dieses Beitrags wurden wie folgt zusammengefasst:

Wirkstoffe der Medikamente:

Patientendaten:

Die Nebenwirkung dauert an

Eingetragen durch Patient

Kommentare zu diesem Erfahrungsbericht:

Budes N fur Asthma mit keine Nebenwirkungen

Budes N bei Asthma

Wegen welcher Krankheit

Dauer der Einnahme

Beschreibung der unerwunschten Nebenwirkung:

Eingetragen am 01.05.2007 als Datensatz 1084

Die Nebenwirkungen dieses Beitrags wurden wie folgt zusammengefasst:

Wirkstoffe der Medikamente:

Patientendaten:

Die Nebenwirkung ist behoben

Eingetragen durch Patient

Kommentare zu diesem Erfahrungsbericht:

Budes fur Allergie mit Halskratzen

Nutze Budes 64µg schon seit 1 1/2 Jahren taglich (Heuschnupfen und au?er der "Saison" Tierhaare). Kann au?er ab und an leichtem Kratzen im Hals nichts Negatives uber dieses Spray berichten. Hatte vorher Vividrin. - Eine Katastrophe! Hatte Kehlkopfschwellung, 3Wochen lang. War net so angenehm.

Budes bei Allergie

Beschreibung der unerwunschten Nebenwirkung:

Mein Sohn nimmt seit zwei Jahren Budes Inhalierspray uber eine Inhalierhilfe und phasenweise zusatzlich Salbutamol-Spray ebenfalls uber diese Inhalierhilfe - habe bislang keine Nebenwirkungen festgestellt - er wird jedoch auch regelma?ig (alle drei Monate) gemessen, gewogen und untersucht.

Eingetragen am 08.10.2007 als Datensatz 4370

Die Nebenwirkungen dieses Beitrags wurden wie folgt zusammengefasst:

Wirkstoffe der Medikamente:

Patientendaten:

Die Nebenwirkung ist behoben

Eingetragen durch Angehoriger

Kommentare zu diesem Erfahrungsbericht:

Budes fur chronischer Schnupfen mit keine Nebenwirkungen

Also ich habe das Budes Nasenspray das erste Mal von meiner Arztin verschrieben bekommen, da ich seit 3Monaten an einer chronisch verstopften Nase gelitten habe. Ich war zuerst sehr skeptisch, da es cortison haltig ist. Ich habe das Spray jetzt 3 Tage benutzt und ich bin wirklich positiv.

Budes bei chronischer Schnupfen

Beschreibung der unerwunschten Nebenwirkung:

Hochzufrieden! Ich habe wirklich schlimmen Heuschnupfen und Cetirizin ist bei mir wirkungslos. Der Arzt meinte, es gibt zwei Arten, warum der Korper auf die Pollen reagiert, die ahnliche Symptome aber unterschiedliche Ursachen haben, bei der einen helfe Cetirizin bei der anderen eben Kortison. Nebenwirkungen hatte ich keine!

Eingetragen am 02.12.2014 als Datensatz 65152

Die Nebenwirkungen dieses Beitrags wurden wie folgt zusammengefasst:

Wirkstoffe der Medikamente:

Patientendaten:

Eingetragen durch Patient

Kommentare zu diesem Erfahrungsbericht:

Budes fur Nasennebenhohlenkarzinom mit keine Nebenwirkungen

Hat gar nicht gewirkt die Nase war und blieb verstopft auch bei Erhohung um 2 mal taglich 2 Spruhsto?e. Bei meinem Freund war es genau so. Er hatte starken Schnupfen und ich Nasennebenhohlenentzundung. Auch fur meinen Heuschnupfen 3 Monate spater keine Wirkung! Nebenwirkungen keine !

Budes bei Nasennebenhohlenkarzinom

Beschreibung der unerwunschten Nebenwirkung:

Also mein Sohn ist 7 Jahre alt. Und er hat von Geburt an Luftprobleme. Kam 8 Wochen vor Stichtag. Und hat Asthma. Wir nehmen ca. seit 3 Jahren Salbutamol Inhalierspray und Budes Inhalierspray ( Oder BudiAir aber das wurd nicht mehr verschrieben) Und wir mussen festellen das er je mehr er das Salbutamol Spray nimmt, um so gestresster ist er selbst, aufgekratzt, hibbelig, und manchmal unertraglich hampelig und man kann kaum was mit ihm unternehmen. So viel dazu :-(

Eingetragen am 22.03.2009 als Datensatz 14100

Die Nebenwirkungen dieses Beitrags wurden wie folgt zusammengefasst:

Wirkstoffe der Medikamente:

Patientendaten:

Die Nebenwirkung ist behoben

Eingetragen durch Patient

Kommentare zu diesem Erfahrungsbericht:

Budes fur Allergische Rhinitis mit keine Nebenwirkungen

Ich habe Budenosid als Nasenspray unter dem Namen Budes32 angewendet. Gut wirksame zeitlich befristete Symptombehandlung ohne erkennbare Nebenwirkungen, nach den eigentlichen Ursachen der Reaktion bin ich noch auf der Suche. Histaminintoleranz wird jetzt abgeklart.

Budes bei Allergische Rhinitis

Budes

Beschreibung der unerwunschten Nebenwirkung:

Aufgrund meines Horsturzes musste ich obige Medikamente nehmen. Im Laufe der Zeit traten folgende Sachen auf: Zittrigkeit der Hande, Ohrensausen als ob der Kopf in Watte gehullt ist, geschwollene Beine und Hande abends, Nachtschwei?, tagsuber zittern vor Kalte, allgemeines Unruhe - gefuhl wie unter Starkstrom. Als ich zum Schluss auch noch ein Gefuhl in der Brust bekam, als ob ein Eisenring drum liegt, kaum Luft bekommen habe, setzte ich die Trental seit 2 Tagen ab. Beim Prednihexal bin ich beim rausschleichen. Aber die Luftenge habe ich immer noch und alle anderen Beschwerden auch noch. Inwieweit eine Wechselwirkung mit meinen anderen Medikamenten besteht, kann ich nicht sagen.

Eingetragen am 11.01.2009 als Datensatz 12468

Die Nebenwirkungen dieses Beitrags wurden wie folgt zusammengefasst:

Wirkstoffe der Medikamente:

Patientendaten:

Die Nebenwirkung dauert an

Eingetragen durch Patient

Kommentare zu diesem Erfahrungsbericht:

Budes N fur Asthma mit keine Nebenwirkungen

Budes N bei Asthma

Wegen welcher Krankheit

Dauer der Einnahme

Beschreibung der unerwunschten Nebenwirkung:

Eingetragen am 01.05.2007 als Datensatz 1084

Die Nebenwirkungen dieses Beitrags wurden wie folgt zusammengefasst:

Wirkstoffe der Medikamente:

Patientendaten:

Die Nebenwirkung ist behoben

Eingetragen durch Patient

Kommentare zu diesem Erfahrungsbericht:

Budes fur Allergie mit Halskratzen

Nutze Budes 64µg schon seit 1 1/2 Jahren taglich (Heuschnupfen und au?er der "Saison" Tierhaare). Kann au?er ab und an leichtem Kratzen im Hals nichts Negatives uber dieses Spray berichten. Hatte vorher Vividrin. - Eine Katastrophe! Hatte Kehlkopfschwellung, 3Wochen lang. War net so angenehm.

Budes bei Allergie

Beschreibung der unerwunschten Nebenwirkung:

Mein Sohn nimmt seit zwei Jahren Budes Inhalierspray uber eine Inhalierhilfe und phasenweise zusatzlich Salbutamol-Spray ebenfalls uber diese Inhalierhilfe - habe bislang keine Nebenwirkungen festgestellt - er wird jedoch auch regelma?ig (alle drei Monate) gemessen, gewogen und untersucht.

Eingetragen am 08.10.2007 als Datensatz 4370

Die Nebenwirkungen dieses Beitrags wurden wie folgt zusammengefasst:

Wirkstoffe der Medikamente:

Patientendaten:

Die Nebenwirkung ist behoben

Eingetragen durch Angehoriger

Kommentare zu diesem Erfahrungsbericht:

Budes fur chronischer Schnupfen mit keine Nebenwirkungen

Also ich habe das Budes Nasenspray das erste Mal von meiner Arztin verschrieben bekommen, da ich seit 3Monaten an einer chronisch verstopften Nase gelitten habe. Ich war zuerst sehr skeptisch, da es cortison haltig ist. Ich habe das Spray jetzt 3 Tage benutzt und ich bin wirklich positiv.

Budes bei chronischer Schnupfen

Beschreibung der unerwunschten Nebenwirkung:

Hochzufrieden! Ich habe wirklich schlimmen Heuschnupfen und Cetirizin ist bei mir wirkungslos. Der Arzt meinte, es gibt zwei Arten, warum der Korper auf die Pollen reagiert, die ahnliche Symptome aber unterschiedliche Ursachen haben, bei der einen helfe Cetirizin bei der anderen eben Kortison. Nebenwirkungen hatte ich keine!

Eingetragen am 02.12.2014 als Datensatz 65152

Die Nebenwirkungen dieses Beitrags wurden wie folgt zusammengefasst:

Wirkstoffe der Medikamente:

Patientendaten:

Eingetragen durch Patient

Kommentare zu diesem Erfahrungsbericht:

Budes fur Nasennebenhohlenkarzinom mit keine Nebenwirkungen

Hat gar nicht gewirkt die Nase war und blieb verstopft auch bei Erhohung um 2 mal taglich 2 Spruhsto?e. Bei meinem Freund war es genau so. Er hatte starken Schnupfen und ich Nasennebenhohlenentzundung. Auch fur meinen Heuschnupfen 3 Monate spater keine Wirkung! Nebenwirkungen keine !

Budes bei Nasennebenhohlenkarzinom

Beschreibung der unerwunschten Nebenwirkung:

Also mein Sohn ist 7 Jahre alt. Und er hat von Geburt an Luftprobleme. Kam 8 Wochen vor Stichtag. Und hat Asthma. Wir nehmen ca. seit 3 Jahren Salbutamol Inhalierspray und Budes Inhalierspray ( Oder BudiAir aber das wurd nicht mehr verschrieben) Und wir mussen festellen das er je mehr er das Salbutamol Spray nimmt, um so gestresster ist er selbst, aufgekratzt, hibbelig, und manchmal unertraglich hampelig und man kann kaum was mit ihm unternehmen. So viel dazu :-(

Eingetragen am 22.03.2009 als Datensatz 14100

Die Nebenwirkungen dieses Beitrags wurden wie folgt zusammengefasst:

Wirkstoffe der Medikamente:

Patientendaten:

Die Nebenwirkung ist behoben

Eingetragen durch Patient

Kommentare zu diesem Erfahrungsbericht:

Budes fur Allergische Rhinitis mit keine Nebenwirkungen

Ich habe Budenosid als Nasenspray unter dem Namen Budes32 angewendet. Gut wirksame zeitlich befristete Symptombehandlung ohne erkennbare Nebenwirkungen, nach den eigentlichen Ursachen der Reaktion bin ich noch auf der Suche. Histaminintoleranz wird jetzt abgeklart.

Budes bei Allergische Rhinitis

Aciclovir - Anti Viral, Erpaclovir

Anti Viral - Erpaclovir (Brand name: aciclovir)

Common use Aciclovir is an antiviral drug, it is a synthetic ingredient with a similar molecular structure to purine nucleoside. Aciclovir is used to treat viral infections such as cold sores, to stop the growth of Herpes simplex virus, Varicella zoster virus (caused by chickenpox and shingles), Epstein Barr Virus (caused by glandular fever), and to a lesser extent Cytomegalovirus (CMV). It is also useful in preventing genital herpes and in preventing viral infections occurring in those with a lowered immune system. This medication may also help reduce the time when pain remains after the sores heal. In addition, in people with a weakened immune system, Aciclovir can decrease the risk of the virus spreading to other parts of the body and causing serious infections.

Dosage and direction

Take this medication by mouth with or without food, usually 2 to 5 times a day as directed by your doctor. Take this medicine by mouth with a glass of water. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think your are better. If you are using the liquid form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Dosage is based on your medical condition and response to treatment. In children, dosage is also based on weight.

You should talk with your healthcare provider prior to taking Aciclovir if you have kidney disease, including kidney failure (renal failure), any allergies, including allergies to food, dyes, or preservatives. Let your healthcare provider know if you are pregnant or thinking of becoming pregnant, breastfeeding. Make sure to tell your healthcare provider about all medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. The medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug.

Aciclovir Injection is contraindicated for patients who develop hypersensitivity to Erpaclovir or valaciclovir.

Possible side effects Side effects are potentially serious and you should report to your doctor or health care professional as soon as possible. These include, but are not limited to: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, chest pain, confusion, hallucinations, tremor, dark urine, increased sensitivity to the sun, redness, blistering, peeling or loosening of the skin (including inside the mouth), seizures, trouble passing urine or change in the amount of urine, unusual bleeding or bruising, or pinpoint red spots on the skin, unusually weak or tired, yellowing of the eyes or skin. Side effects that usually do not require medical attention: diarrhea, fever, headache, nausea, vomiting stomach upset. In this way report to your doctor or health care professional if they continue or are bothersome.

Drug interactions There are negative interactions that can occur when Aciclovir is combined with any of the drugs listed above. Phenytoin (Fosphenytoin) and Aciclovir: it may decrease the level of phenytoin in your blood, perhaps making it less effective. Your healthcare provider may need to measure the level of phenytoin in your blood (using a blood test) and adjust your dose as necessary. Probenecid can increase the level of Aciclovir in your blood, increasing your risk of acyclovir side effects. Your healthcare provider may need to decrease your acyclovir dosage to prevent this interaction from occurring. Acyclovir can increase the level of Tenofovir in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to lower your tenofovir dosage to prevent drug interactions.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include seizure (convulsions), hallucinations, and urinating less than usual or not at all.

Store at controlled room temperature of 15°C to 25°C (59°F to 77°F). Keep this medicine out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use Aciclovir is an antiviral drug, it is a synthetic ingredient with a similar molecular structure to purine nucleoside. Aciclovir is used to treat viral infections such as cold sores, to stop the growth of Herpes simplex virus, Varicella zoster virus (caused by chickenpox and shingles), Epstein Barr Virus (caused by glandular fever), and to a lesser extent Cytomegalovirus (CMV). It is also useful in preventing genital herpes and in preventing viral infections occurring in those with a lowered immune system. This medication may also help reduce the time when pain remains after the sores heal. In addition, in people with a weakened immune system, Aciclovir can decrease the risk of the virus spreading to other parts of the body and causing serious infections.

Dosage and direction

Take this medication by mouth with or without food, usually 2 to 5 times a day as directed by your doctor. Take this medicine by mouth with a glass of water. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think your are better. If you are using the liquid form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Dosage is based on your medical condition and response to treatment. In children, dosage is also based on weight.

You should talk with your healthcare provider prior to taking Aciclovir if you have kidney disease, including kidney failure (renal failure), any allergies, including allergies to food, dyes, or preservatives. Let your healthcare provider know if you are pregnant or thinking of becoming pregnant, breastfeeding. Make sure to tell your healthcare provider about all medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. The medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug.

Aciclovir Injection is contraindicated for patients who develop hypersensitivity to Erpaclovir or valaciclovir.

Possible side effects Side effects are potentially serious and you should report to your doctor or health care professional as soon as possible. These include, but are not limited to: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, chest pain, confusion, hallucinations, tremor, dark urine, increased sensitivity to the sun, redness, blistering, peeling or loosening of the skin (including inside the mouth), seizures, trouble passing urine or change in the amount of urine, unusual bleeding or bruising, or pinpoint red spots on the skin, unusually weak or tired, yellowing of the eyes or skin. Side effects that usually do not require medical attention: diarrhea, fever, headache, nausea, vomiting stomach upset. In this way report to your doctor or health care professional if they continue or are bothersome.

Drug interactions There are negative interactions that can occur when Aciclovir is combined with any of the drugs listed above. Phenytoin (Fosphenytoin) and Aciclovir: it may decrease the level of phenytoin in your blood, perhaps making it less effective. Your healthcare provider may need to measure the level of phenytoin in your blood (using a blood test) and adjust your dose as necessary. Probenecid can increase the level of Aciclovir in your blood, increasing your risk of acyclovir side effects. Your healthcare provider may need to decrease your acyclovir dosage to prevent this interaction from occurring. Acyclovir can increase the level of Tenofovir in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to lower your tenofovir dosage to prevent drug interactions.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include seizure (convulsions), hallucinations, and urinating less than usual or not at all.

Store at controlled room temperature of 15°C to 25°C (59°F to 77°F). Keep this medicine out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Leflunomide Brands, Medical Use, Clinical Data, Leflunomidum

Active ingredient: Leflunomide - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

Immunosuppressive Agents

Antivirals

Antiparasitics

Antineoplastic Agents

Anti-inflammatory Agents

Adjuvants

Arava ; Leflunomide [Usan:Inn]; Leflunomidum [Inn-Latin]; Lefunomide; [Inn-Spanish]

For the treatment of active rheumatoid arthritis (RA).

Leflunomide is a pyrimidine synthesis inhibitor indicated in adults for the treatment of active rheumatoid arthritis (RA). RA is an auto-immune disease characterized by high T-cell activity. T cells have two pathways to synthesize pyrimidines: the salvage pathways and the de novo synthesis. At rest, T lymphocytes meet their metabolic requirements by the salvage pathway. Activated lymphocytes need to expand their pyrimidine pool 7- to 8-fold, while the purine pool is expanded only 2- to 3-fold. To meet the need for more pyrimidines, activated T cells use the de novo pathway for pyrimidine synthesis. Therefore, activated T cells, which are dependent on de novo pyrimidine synthesis, will be more affected by leflunomide's inhibition of dihydroorotate dehydrogenase than other cell types that use the salvage pathway of pyrimidine synthesis.

Mechanism of Action

Leflunomide is an isoxazole immunomodulatory agent which inhibits dihydroorotate dehydrogenase (an enzyme involved in de novo pyrimidine synthesis) and has antiproliferative activity. Specifically Leflunomide blocks the de novo synthesis of pyrimidines, thus preventing the proliferation of activated T cells. Several in vivo and in vitro experimental models have demonstrated an anti-inflammatory effect. Following oral administration, leflunomide is metabolized to an active metabolite A77 1726 which is responsible for essentially all of its activity in vivo .

Well absorbed, peak plasma concentrations appear 6-12 hours after dosing

LD 50 =100-250 mg/kg (acute oral toxicity)

Biotrnasformation / Drug Metabolism

Primarily hepatic. Leflunomide is converted to its active form following oral intake.

ARAVA is contraindicated in patients with known hypersensitivity to leflunomide or any of the other components of ARAVA.

ARAVA can cause fetal harm when administered to a pregnant woman. Leflunomide, when administered orally to rats during organogenesis at a dose of 15 mg/kg, was teratogenic (most notably anophthalmia or microophthalmia and internal hydrocephalus). The systemic exposure of rats at this dose was approximately 1/10 the human exposure level based on AUC. Under these exposure conditions, leflunomide also caused a decrease in the maternal body weight and an increase in embryolethality with a decrease in fetal body weight for surviving fetuses. In rabbits, oral treatment with 10 mg/kg of leflunomide during organogenesis resulted in fused, dysplastic sternebrae. The exposure level at this dose was essentially equivalent to the maximum human exposure level based on AUC. At a 1 mg/kg dose, leflunomide was not teratogenic in rats and rabbits.

When female rats were treated with 1.25 mg/kg of leflunomide beginning 14 days before mating and continuing until the end of lactation, the offspring exhibited marked (greater than 90%) decreases in postnatal survival. The systemic exposure level at 1.25 mg/kg was approximately 1/100 the human exposure level based on AUC.

ARAVA is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.

Cholestyramine and Charcoal Administration of cholestyramine or activated charcoal in patients (n=13) and volunteers (n=96) resulted in a rapid and significant decrease in plasma M1 (the active metabolite of leflunomide) concentration .

Hepatotoxic Drugs Increased side effects may occur when leflunomide is given concomitantly with hepatotoxic substances. This is also to be considered when leflunomide treatment is followed by such drugs without a drug elimination procedure. In a small (n=30) combination study of ARAVA with methotrexate, a 2- to 3-fold elevation in liver enzymes was seen in 5 of 30 patients. All elevations resolved, 2 with continuation of both drugs and 3 after discontinuation of leflunomide. A >3-fold increase was seen in another 5 patients. All of these also resolved, 2 with continuation of both drugs and 3 after discontinuation of leflunomide. Three patients met "ACR criteria" for liver biopsy (1: Roegnik Grade I, 2: Roegnik Grade IIIa). No pharmacokinetic interaction was identified.

NSAIDs In in vitro studies, M1 was shown to cause increases ranging from 13 - 50% in the free fraction of diclofenac and ibuprofen at concentrations in the clinical range. The clinical significance of this finding is unknown; however, there was extensive concomitant use of NSAIDs in clinical studies and no differential effect was observed.

Tolbutamide In in vitro studies, M1 was shown to cause increases ranging from 13 - 50% in the free fraction of tolbutamide at concentrations in the clinical range. The clinical significance of this finding is unknown.

Rifampin Following concomitant administration of a single dose of ARAVA to subjects receiving multiple doses of rifampin, M1 peak levels were increased (

40%) over those seen when ARAVA was given alone. Because of the potential for ARAVA levels to continue to increase with multiple dosing, caution should be used if patients are to be receiving both ARAVA and rifampin.

Warfarin Increased INR (International Normalized Ratio) when ARAVA and warfarin were co-administered has been rarely reported.

Jw Marriott Hotel Washington, Dc, Olyster

JW Marriott Hotel Washington, DC 4.0

Review Summary

Pros

Around the corner from the White House

Extremely comfortable bedding

Well-wired: Internet access on the TV with a wireless keyboard; connectivity panel in each room with cables to hook up your computer, iPods, DVD players, digital cameras to TV

Large indoor pool and Jacuzzi ; 24-hour fitness room.

Outdoor pool-level courtyard terrace (closed in winter)

A patio on the top floor with panaromic views of Pennsylvania Avenue

Cons

Huge and somewhat impersonal

Daily fee for Internet access

Expensive full-service business center ; computer use and laptop connection available

No spa

Pricey parking fee

Bottom Line

A no-nonsense luxury hotel for the masses just steps away from the White House, the JW Marriott has a shopping mall-like multistory lobby and 772 cozy guestrooms. It's modestly plush, but in a populist way -- especially when compared with the place across the street, the Intercontinental Willard. which is richer and more exclusive.

Oyster Awards

Oyster Hotel Photos

Corner King Room

King Room with Pennsylvania Avenue Views

Restaurants and Bars

Oyster Hotel Review

Scene

An impersonal but modestly luxurious hotel with a few unique details and amenities

The JW Marriott is one of a handful of privileged hotels that rubs shoulders with the White House -- among the others are the Hay-Adams. W. Intercontinental Willard. and Sofitel Hotel Lafayette Square. The 772-room Marriott is big and practical but, unlike the others in the immediate vicinity, neither historic (it was built in 1985) nor particularly elegant. It looks like an office building on the outside; inside the lobby it could pass for an upscale shopping mall, with a three-story atrium lobby. lots of escalators. a gift shop. and a Starbucks .

That said, the guest rooms were renovated in 2006 and still feel fresh and modestly luxurious. Standard rooms are an adequate 300 square feet, which is about average for Washington, but the bedding is high end, the carpeting is remarkably plush, and the up-to-date electronics include 37-inch flat-screen TVs. The amenities. meanwhile, are better than adequate: a 30-foot-long swimming pool and a full-service, 24-hour business center with an attendant.

Service

Professional and thorough

The hotel staff is thorough and professional. Teams of uniformed porters and parking attendants work the front entrance. greeting everyone at their car even during the busiest rush. The concierge desk is often manned by two unusually helpful attendants. The manager conscientiously works the lobby at rush hour, welcoming new guests and thanking those departing. It's a command performance, and she's got a fantastic memory.

Concierge available daily

24-hour room service with limited overnight menu

The Concierge Lounge on the 14th floor serves guests on the top two executive floors with free breakfast snacks, newspapers, magazines.

Turndown service on request

Pricey valet parking

Location

On Pennsylvania Avenue, near the White House and a few blocks from monuments on the Mall

Tourists may not need a car in D. C. and that's especially true if they're staying at the JW Marriott, which is close to all the major monuments and museums and just a few blocks away from the Metro Center, a major hub in the city's excellent subway system. Located in the compact section of the city called Penn Quarter. on the border of downtown. the JW Marriott is a safe, convenient option for both business and leisure travelers -- full of restaurants and shops (well-known franchises, mostly), but still close to the major sights (the White House is just a short walk away). The once-seedy section of town has, in recent decades, been revamped by urban renewal projects -- the most recognizable of which is the Verizon Center sports arena, about six blocks away. Other nearby attractions include the International Spy Museum, FBI headquarters at the J. Edgar Hoover Building, Ford's Theatre, the National Archives, the National Portrait Gallery, and the National Theatre. Skirting the neighborhood are Chinatown and the Walter E. Washington Convention Center; just south lies the National Mall and all its attractions.

10-minute drive cab ride to the Capitol and Union Station

20-minute walk, or about 10 minutes by car, to the monuments on the National Mall

10- to 15-minute drive to Reagan National Airport

27-mile, 60-minute dirve to Dulles International Airport

Buy Procaptan Perindopril Erbumine Online Without Prescriptions, Procaptan

Aceon is used for treating high blood pressure. Aceon is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking ACE, an enzyme involved in narrowing blood vessels and causing sodium and fluid retention by the kidneys. This causes blood vessels to relax, allowing blood to flow more freely and at a lower pressure, and increasing the heart's ability to pump blood in some types of heart failure.

Use Aceon as directed by your doctor.

You may take Aceon with or without food.

Take Aceon regularly to receive the most benefit from it. Taking Aceon at the same time each day will help you to remember to take it. Continue taking Aceon even if you feel well.

If you miss a dose of Aceon, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Aceon.

Active Ingredient: Perindopril erbumine.

Store Aceon at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, light, and moisture. Keep Aceon out of the reach of children and away from pets.

Do NOT use Aceon if:

you are allergic to any ingredient in Aceon

you are in the second or third trimester of pregnancy

you have a history of giant hives or skin inflammation caused by ACE inhibitors

you are taking or have taken dextran sulfate within the past 3 days.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Aceon. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of giant hives or skin inflammation, or hardening of the skin or organs

if you have bone marrow depression, blood vessel problems in the brain (including stroke), or severe immune system disease

if you are undergoing dialysis

if you have high blood potassium, low blood sodium, or are on a sodium-restricted diet

if you have ischemic heart disease, liver or kidney problems (including transplant), or lupus, or you are dehydrated.

Some medicines may interact with Aceon. Tell your health care provider if you are taking any other medicines, especially any of the following:

Indomethacin, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or salicylates (eg, aspirin) because the effectiveness of Aceon may be decreased

Clozapine, cyclosporine, dextran sulfate, HMG-CoA reductase inhibitors (eg, simvastatin), indomethacin, mannitol, NSAIDs (eg, ibuprofen), pergolide, phenothiazines (eg, chlorpromazine), potassium, potassium-sparing diuretics (eg, triamterene), thiazide-type diuretics (eg, hydrochlorothiazide), or trimethoprim because the actions and side effects of Aceon and these medicines may be increased.

Iron, lithium, sulfonylureas (eg, glyburide), or thiopurines (eg, azathioprine) because the actions and side effects of these medicines may be increased.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aceon may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Aceon may cause dizziness or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Aceon. Using Aceon alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

Dizziness or lightheadedness may occur if you stand up too fast from a lying or sitting position. Avoid sudden changes in posture.

Drink plenty of fluids while taking Aceon and avoid engaging in activities that cause excessive sweating. Dehydration, excessive sweating, vomiting, or diarrhea may lead to a fall in blood pressure. Contact your health care provider at once if any of these occur.

A persistent, unproductive cough may occur. Tell your doctor if this occurs. Recovery is rapid when the medicine is stopped.

Patients being treated for high blood pressure often feel tired or run down for a few weeks after beginning therapy. Continue taking our medicine even though you may not feel quite "normal." Contact your doctor or pharmacist about any new symptoms.

Black patients are at higher risk for certain side effects, and may not respond as well to Aceon as patients of other races.

Before you have any medical or dental treatments, emergency care, or surgery, tell your doctor or dentist that you are taking Aceon.

Aceon may lower your resistance to infection. Prevent infection by avoiding contact with people with colds or other infections. Do not touch you eyes or the inside of your nose unless you have thoroughly washed your hands first.

Do not use salt substitutes containing potassium without first talking with your health care provider.

It may take several weeks for Aceon to work. Do not stop taking Aceon without checking with your health care provider.

Lab tests, including liver function, kidney function, blood pressure, blood counts, and blood electrolytes, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Caution is advised when using Aceon in the elderly because they may be more sensitive to its effects, especially dizziness and rash.

Children should use Aceon with extreme caution. Safety and effectiveness have not been confirmed.

Pregnancy and breast-feeding: Aceon has been shown to cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Aceon during pregnancy. It is unknown if Aceon is excreted in breast milk. Do not breast-feed while taking Aceon.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Abnormal skin sensation; arm or leg pain; back pain; cough; depression; diarrhea; dizziness; drowsiness; headache; lightheadedness; nausea; runny nose; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in the amount of urine; chest pain; darkening of urine; difficulty swallowing; fainting; fast or irregular heartbeat; fever; hoarseness; pounding in the chest; prolonged nausea, vomiting, or diarrhea; severe lightheadedness or fainting; sore throat; swelling of the hands, legs, face, lips, eyes, throat, tongue, or trunk; unusual joint pain; unusual muscle pain, cramps, or weakness; unusual stomach pain; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Macladin - Drug Review Dosage, Side Effects, Action, Buy Macladin, Macladin

Macladin

Macladin review

Antibiotics are classified into different groups based to their strength in tackling bacteria and the diseasees that come with them. While Cefixim and Cephalexin are included in the milder group of cephalosporin antibiotics, Macladin is in the stronger group of macrolide antibiotics. Macladin is found useful in severe cases of infections in the lungs (pneumonia), the tubes that lead to the lungs (bronchitis), and in the skin. It is even helpful in controlling the spread of bacteria in HIV/AIDS patients.

Macladin was developed in Japanese labs in the 1970s. It was a byproduct of a different version of erythromycin gone wrong. More than a decade later, an American company, Abbott Laboratories, created a partnership with the original manufacturer of Macladin, Taisho, to gain its international rights. In 2004, the medication became a generic brand in Europe and in the United States the following year.

Macladin is usually taken by mouth as a pill and oral suspension. There are also gel and lotion versions of the medication, created for topical use. Macladin is effective in preventing bacteria from growing and from spreading. It has antimicrobial effects similar to erythromycin but is far more effective and safe. Macladin, especially the pill and liquid form, will not cause discomfort if taken on an empty stomach. It is easily absorbed by the body and distributed into the site of infection. When using the oral suppression pills, it is best that the medication be taken with food.

A missed dose should be taken immediately. However, if the realization is too close to your next scheduled dose, skip the missed dose and continue with your normal schedule. Never take a double dose of Macladin and do not stop your intake of the medicine prematurely. Some symptoms may stop before the bacteria are killed. Since your goal is to kill the bacteria and stop it from spreading, you need to take it for the advised period of time. Following your doctor's prescription is important to keep you safe.

Like any strong medication, Macladin has some side effects. Diarrhea. vomiting. and swelling on the face are common reactions towards this medication. Some side effects could be severe and may include headache. motion sickness. skin rashes, xerostomia, anxiety attacks, hallucinations. yellowish skin, and kidney failure. If you experience any of these, rush to your doctor immediately. Any side effect that does not appear normal or is causing you discomfort should be a cause for alarm and you should consult your doctor immediately.

Special precautions should be taken by those with histories of allergies. asthma. hives. liver disease, kidney ailment, heart problem, or electrolyte imbalance. Macladin is not recommended for patients with these conditions as the reaction may be severe or life threatening. When taking a prescription medicine like this, your doctor's advice is always necessary. They will determine whether the medication is appropriate for you or not and will regulate your intake to ensure that no damage is done.

Macladin has the following structural formula:

• Molecular formula of macladin is C38H69NO13 • Chemical IUPAC Name is 6-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy - 14-ethyl-12,13-dihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-7- methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione • Molecular weight is 747.953 g/mol • Macladin available. 125mg/5ml suspension 100ml bottle, 250mg/5ml suspension 100ml bottle, 125mg/5ml suspension 50ml bottle, 250mg/5ml suspension 50ml bottle, 250mg tablets, 500mg tablets

Generic name: Clarithromycin

Resilo Guide - Resilo, Resilo

ReSilo Guide

Framework Categories

the framework should be used to inspire unique ReSilo solutions, which are relatable to the sites specific context.

Consider the framework as a guide to identify what is unique about your site, what and how could its recontextualization contribute to the community or its surroundings. Each category can be considered in any hierarchy that is relative to your site, or which you see as most important. Use the below pdf as a working document to work out what that is.

Discover the values, beliefs, interests, economy, desires and demographics that influence individuals & groups within the community. If the site is to become a landmark for the community, this category is essential to developing a unique design solution.

Research the key events and history of the site and the surrounding area. Insight into the history of the site can provide surprising outcomes. Many sites have found success in finding a unique way to embrace the heritage of the original silo and its place in the industry.

Form an understanding of the unique spatial experience the silo configuration offers. Although many silos appear similar from the exterior, they are commonly have differences. It is important to also consider the silos condition, structural integrity, square footage & layout.

Develop an understanding of the sites climate, topography, strengths and weaknesses of the location and its proximities. Some may take this as a site analysis and others may use it to draw design inspiration in abstract or literal methods. Go to our pdf above for more information!

Cilostazol - Fda Prescribing Information, Side Effects And Uses, Cilostazolum

Cilostazol

WARNING: CONTRAINDICATED IN HEART FAILURE PATIENTS

Cilostazol tablets are contraindicated in patients with heart failure of any severity. Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with the pharmacologic effect have caused decreased survival compared to placebo patients with class III-IV heart failure.

Indications and Usage for Cilostazol

Cilostazol tablets are indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance.

Cilostazol Dosage and Administration

Recommended Dosage

The recommended dosage of Cilostazol is 100 mg twice daily taken at least half an hour before or two hours after breakfast and dinner.

Patients may respond as early as 2 to 4 weeks after the initiation of therapy, but treatment for up to 12 weeks may be needed before a beneficial effect is experienced. If symptoms are unimproved after 3 months, discontinue Cilostazol.

Dose Reduction with CYP3A4 and CYP2C19 Inhibitors

Reduce dose to 50 mg twice daily when co-administered with strong or moderate inhibitors of CYP3A4 (e. g. ketoconazole, itraconazole, erythromycin, and diltiazem) or inhibitors of CYP2C19 (e. g. ticlopidine, fluconazole, and omeprazole) [ see Drug Interactions (7.1 ) ]

Dosage Forms and Strengths

Cilostazol Tablets USP are available as 50 mg and 100 mg round, white tablets. The 50 mg tablet is a flat faced beveled edge tablet, debossed with product identification “54 521” on one side and plain on the other side. The 100 mg tablet is a biconvex tablet, debossed with product identification “54 757” on one side and plain on the other side.

Contraindications

Cilostazol is contraindicated in patients with:

• Heart failure of any severity: Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with this pharmacologic effect have caused decreased survival compared to placebo in patients with class III-IV heart failure.

Hypersensitivity to Cilostazol or any components of Cilostazol (e. g. anaphylaxis, angioedema).

Warnings and Precautions

Tachycardia

Cilostazol may induce tachycardia, palpitation, tachyarrhythmia or hypotension. The increase in heart rate associated with Cilostazol is approximately 5 to 7 bpm. Patients with a history of ischemic heart disease may be at risk for exacerbations of angina pectoris or myocardial infarction.

Hematologic Adverse Reactions

Cases of thrombocytopenia or leukopenia progressing to agranulocytosis when Cilostazol was not immediately discontinued have been reported. Agranulocytosis is reversible on discontinuation of Cilostazol. Monitor platelets and white blood cell counts periodically.

Hemostatic Disorders or Active Pathologic Bleeding

Cilostazol inhibits platelet aggregation in a reversible manner. Cilostazol has not been studied in patients with hemostatic disorders or active pathologic bleeding. Avoid use of Cilostazol in these patients.

Adverse Reactions

The following adverse reactions are discussed in greater detail in other sections of the labeling:

• Patients with Heart Failure [ see Boxed Warning ] • Tachycardia [ see Warnings and Precautions (5.1 ) ] • Hematologic Adverse Reactions [ see Warnings and Precautions (5.2 ) ] • Hemostatic Disorders or Active Pathologic Bleeding [ see Warnings and Precautions (5.3 ) ]

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Adverse reactions were assessed in eight placebo-controlled clinical trials involving patients exposed to either 50 or 100 mg twice daily Cilostazol (n=1301) or placebo (n=973), with a median treatment duration of 127 days for patients on Cilostazol and 134 days for patients on placebo.

The most frequent adverse reaction resulting in discontinuation of therapy in more than 3% of patients treated with Cilostazol was headache [50 mg twice daily (1.3%), 100 mg twice daily (3.5%) and placebo (0.3%)]. Other frequent causes of discontinuation included palpitation and diarrhea, both 1.1% for Cilostazol (all doses) versus 0.1% for placebo.

The most common adverse reactions, occurring in at least 2% of patients treated with Cilostazol 50 or 100 mg twice daily, are shown in Table 1.

Table 1: Most Common Adverse Reactions in Patients on Cilostazol 50 or 100 mg Twice Daily (Incidence at least 2% and Occurring More Frequently (≥ 2%) in the 100 mg Twice Daily Group than on Placebo)

Less frequent clinical significant adverse reactions (less than 2%) that were experienced by patients treated with Cilostazol

50 mg twice daily or 100 mg twice daily in the eight controlled clinical trials and that occurred at a frequency in the 100

mg twice daily group greater than in the placebo group are listed below.

Body as a whole: fever, generalized edema, malaise

Cardiovascular: atrial fibrillation, heart failure, myocardial infarction, nodal arrhythmia, supraventricular tachycardia, ventricular extrasystoles, ventricular tachycardia

Digestive: anorexia, melena

Hematologic and Lymphatic. anemia

Metabolic and Nutritional: increased creatinine, hyperuricemia

Skin and Appendages: urticaria

Special Senses: conjunctivitis, retinal hemorrhage, tinnitus

Urogenital: urinary frequency

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of Cilostazol. Because these reactions are reported voluntarily from a population of an unknown size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Blood and lymphatic system disorders:

Aplastic anemia, granulocytopenia, pancytopenia, bleeding tendency

Torsade de pointes and QTc prolongation in patients with cardiac disorders (e. g. complete atrioventricular block, heart

failure; and bradyarrythmia), angina pectoris.

Gastrointestinal hemorrhage, vomiting, flatulence, nausea

General disorders and administration site conditions:

Pain, chest pain, hot flushes

Hepatic dysfunction/abnormal liver function tests, jaundice

Immune system disorders:

Anaphylaxis, angioedema, and hypersensitivity

Blood glucose increased, blood uric acid increased, increase in BUN (blood urea increased), blood pressure increase

Nervous system disorders:

Intracranial hemorrhage, cerebral hemorrhage, cerebrovascular accident, extradural hematoma and subdural hematoma

Renal and urinary disorders:

Respiratory, thoracic and mediastinal disorders:

Pulmonary hemorrhage, interstitial pneumonia

Skin and subcutaneous tissue disorders:

Hemorrhage subcutaneous, pruritus, skin eruptions including Stevens-Johnson syndrome, skin drug eruption (dermatitis

Subacute stent thrombosis, hypertension.

Drug Interactions

Inhibitors of CYP3A4 or CYP2C19

Inhibitors of CYP3A4

Co-administration of strong (e. g. ketoconazole) and moderate (e. g. erythromycin, diltiazem and grapefruit juice) CYP3A4 inhibitors can increase exposure to Cilostazol. Reduce Cilostazol dose to 50 mg twice daily when co-administered with strong or moderate inhibitors of CYP3A4 [ see Dosage and Administration (2.2 ) and Clinical Pharmacology (12.3 ) ].

Inhibitors of CYP2C19

Co-administration with CYP2C19 inhibitors (e. g. omeprazole) increases systemic exposure of Cilostazol active metabolites. Reduce Cilostazol dose to 50 mg twice daily when co-administered with strong or moderate inhibitors of CYP2C19 [ see Dosage and Administration (2.2 ) and Clinical Pharmacology (12.3 ) ].

USE IN SPECIFIC POPULATIONS

Pregnancy

Teratogenic Effects: Pregnancy Category C .

Cilostazol has been shown to be teratogenic in rats at doses that are greater than 5-times the human MRHD on a body surface area basis. There are no adequate and well-controlled studies in pregnant women.

In a rat developmental toxicity study, oral administration of 1000 mg Cilostazol/kg/day was associated with decreased fetal weights, and increased incidences of cardiovascular, renal, and skeletal anomalies (ventricular septal, aortic arch and subclavian artery abnormalities, renal pelvic dilation, 14 th rib, and retarded ossification). At this dose, systemic exposure to unbound Cilostazol in nonpregnant rats was about 5 times the exposure in humans given the MRHD. Increased incidences of ventricular septal defect and retarded ossification were also noted at 150 mg/kg/day (5 times the MRHD on a systemic exposure basis). In a rabbit developmental toxicity study, an increased incidence of retardation of ossification of the sternum was seen at doses as low as 150 mg/kg/day. In non-pregnant rabbits given 150 mg/kg/day, exposure to unbound Cilostazol was considerably lower than that seen in humans given the MRHD, and exposure to 3,4-dehydroCilostazol was barely detectable.

When Cilostazol was administered to rats during late pregnancy and lactation, an increased incidence of stillborn and decreased birth weights of offspring was seen at doses of 150 mg/kg/day (5 times the MRHD on a systemic exposure basis).

Nursing Mothers

Transfer of Cilostazol into milk has been reported in rats. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Cilostazol, discontinue nursing or discontinue Cilostazol.

Pediatric Use

The safety and effectiveness of Cilostazol in pediatric patients have not been established.

Geriatric Use

Of the total number of subjects (n=2274) in clinical studies of Cilostazol, 56 percent were 65 years old and over, while 16 percent were 75 years old and over. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Pharmacokinetic studies have not disclosed any age-related effects on the absorption, distribution, metabolism, and elimination of Cilostazol and its metabolites.

Hepatic Impairment

No dose adjustment is required in patients with mild hepatic impairment. Patients with moderate or severe hepatic impairment have not been studied in clinical trials and dosing recommendations cannot be provided [ see Clinical Pharmacology (12.3 ) ].

Renal Impairment

No dose adjustment is required in patients with renal impairment. Patients on dialysis have not been studied, but, it is unlikely that Cilostazol can be removed efficiently by dialysis because of its high protein binding (95 to 98%) [ see Clinical Pharmacology (12.3 ) ].

Overdosage

Information on acute overdosage with Cilostazol in humans is limited. The signs and symptoms of an acute overdose can be anticipated to be those of excessive pharmacologic effect: severe headache, diarrhea, hypotension, tachycardia, and possibly cardiac arrhythmias. The patient should be carefully observed and given supportive treatment. Since Cilostazol is highly protein-bound, it is unlikely that it can be efficiently removed by hemodialysis or peritoneal dialysis. The oral LD 50 of Cilostazol is greater than 5 g/kg in mice and rats and greater than 2 g/kg in dogs.

Cilostazol Description

Cilostazol is an quinolinone derivative that inhibits cellular phosphodiesterase (more specific for phosphodiesterase III). The empirical formula of Cilostazol is C 20 H 27 N 5 O 2. and its molecular weight is 369.46. Cilostazol is 6-[4-(1-cyclohexyl-1 H - tetrazol-5-yl)butoxy]-3,4-dihydro-2(1 H )-quinolinone, CAS-73963-72-1. The structural formula is:

Cilostazol USP occurs as white to off-white crystals or as a crystalline powder that is slightly soluble in methanol and ethanol, and is practically insoluble in water, 0.1 N HCl, and 0.1 N NaOH.

Cilostazol Tablets USP are available for oral administration containing 50 mg or and 100 mg Cilostazol USP. Each tablet, in addition to the active ingredient, contains the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate and microcrystalline cellulose.

Each tablet meets the requirements of Test 3 for Dissolution in the USP monograph for Cilostazol Tablets USP.

Cilostazol - Clinical Pharmacology

Mechanism of Action

Cilostazol and several of its metabolites inhibit phosphodiesterase III activity and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation, respectively.

Cilostazol reversibly inhibits platelet aggregation induced by a variety of stimuli, including thrombin, ADP, collagen, arachidonic acid, epinephrine, and shear stress.

Cilostazol affects both vascular beds and cardiovascular function. It produces heterogeneous dilation of vascular beds, with greater dilation in femoral beds than in vertebral, carotid or superior mesenteric arteries. Renal arteries were not responsive to the effects of Cilostazol.

In dogs or cynomolgus monkeys, Cilostazol increased heart rate, myocardial contractile force, and coronary blood flow as well as ventricular automaticity, as would be expected for a PDE III inhibitor. Left ventricular contractility was increased at doses required to inhibit platelet aggregation. A-V conduction was accelerated. In humans, heart rate increased in a dose-proportional manner by a mean of 5.1 and 7.4 beats per minute in patients treated with 50 and 100 mg twice daily, respectively.

Pharmacodynamics

Cilostazol's effects on platelet aggregation were evaluated in both healthy subjects and in patients with stable symptoms of cerebral thrombosis, cerebral embolism, transient ischemic attack, or cerebral arteriosclerosis over a range of doses from 50 mg every day to 100 mg three times a day. Cilostazol significantly inhibited platelet aggregation in a dose-dependent manner. The effects were observed as early as 3 hours post-dose and lasted up to 12 hours following a single dose. Following chronic administration and withdrawal of Cilostazol, the effects on platelet aggregation began to subside 48 hours after withdrawal and returned to baseline by 96 hours with no rebound effect. A Cilostazol dosage of 100 mg twice daily consistently inhibited platelet aggregation induced with arachidonic acid, collagen and adenosine diphosphate (ADP). Bleeding time was not affected by Cilostazol administration.

Effects on circulating plasma lipids have been examined in patients taking Cilostazol. After 12 weeks, as compared to placebo, Cilostazol 100 mg twice daily produced a reduction in triglycerides of 29.3 mg/dL (15%) and an increase in HDL cholesterol of 4.0 mg/dL (≅ 10%).

Short-term (less than or equal to 4 days) co-administration of aspirin with Cilostazol increased the inhibition of ADP-induced ex vivo platelet aggregation by 22% to 37% when compared to either aspirin or Cilostazol alone. Short-term (less than or equal to 4 days) co-administration of aspirin with Cilostazol increased the inhibition of arachidonic acid-induced ex vivo platelet aggregation by 20% compared to Cilostazol alone and by 48% compared to aspirin alone. However, short-term co-administration of aspirin with Cilostazol had no clinically significant impact on PT, aPTT, or bleeding time compared to aspirin alone. Effects of long-term co-administration in the general population are unknown.

In eight randomized, placebo-controlled, double-blind clinical trials, aspirin was co-administered with Cilostazol to 201 patients. The most frequent doses and mean durations of aspirin therapy were 75 to 81 mg daily for 137 days (107 patients) and 325 mg daily for 54 days (85 patients). There was no apparent increase in frequency of hemorrhagic adverse effects in patients taking Cilostazol and aspirin compared to patients taking placebo and equivalent doses of aspirin.

Cilostazol did not inhibit the pharmacologic effects (PT, aPTT, bleeding time, or platelet aggregation) of R - and S-warfarin after a single 25 mg dose of warfarin. The effect of concomitant multiple dosing of warfarin and Cilostazol on the pharmacodynamics of both drugs is unknown.

Pharmacokinetics

Cilostazol is absorbed after oral administration. A high fat meal increases absorption, with an approximately 90% increase in C max and a 25% increase in AUC. Absolute bioavailability is not known. Cilostazol is extensively metabolized by hepatic cytochrome P-450 enzymes, mainly 3A4, and, to a lesser extend, 2C19, with metabolites largely excreted in urine. Two metabolites are active, with one metabolite appearing to account for at least 50% of the pharmacologic (PDE III inhibition) activity after administration of Cilostazol.

Pharmacokinetics are approximately dose proportional. Cilostazol and its active metabolites have apparent elimination half-lives of about 11 to 13 hours. Cilostazol and its active metabolites accumulate about 2-fold with chronic administration and reach steady state blood levels within a few days. The pharmacokinetics of Cilostazol and its two major active metabolites were similar in healthy normal subjects and patients with intermittent claudication due to peripheral arterial disease (PAD). Figure 1shows the mean ± SEM plasma concentration-time profile at steady state after multiple dosing of Cilostazol 100 mg twice daily.

Figure 1: Mean ± SEM Plasma Concentration-time Profile at Steady State after Multiple Dosing of Cilostazol 100 mg Twice Daily

Cilostazol is 95% to 98% protein bound, predominantly to albumin. The mean percent binding for 3,4-dehydro-Cilostazol is 97.4% and for 4'-trans-hydroxy-Cilostazol is 66%. Mild hepatic impairment did not affect protein binding. The free fraction of Cilostazol was 27% higher in subjects with renal impairment than in healthy volunteers. The displacement of Cilostazol from plasma proteins by erythromycin, quinidine, warfarin, and omeprazole was not clinically significant.

Cilostazol is eliminated predominantly by metabolism and subsequent urinary excretion of metabolites. Based on in vitro studies, the primary isoenzymes involved in Cilostazol’s metabolism are CYP3A4 and, to a lesser extent, CYP2C19. The enzyme responsible for metabolism of 3,4-dehydro-Cilostazol, the most active of the metabolites, is unknown.

Following oral administration of 100 mg radiolabeled Cilostazol, 56% of the total analytes in plasma was Cilostazol, 15% was 3,4-dehydro-Cilostazol (4 to 7 times as active as Cilostazol), and 4% was 4'-trans-hydroxy-Cilostazol (20% as active as Cilostazol).

The primary route of elimination was via the urine (74%), with the remainder excreted in the feces (20%). No measurable amount of unchanged Cilostazol was excreted in the urine, and less than 2% of the dose was excreted as 3,4-dehydro-Cilostazol. About 30% of the dose was excreted in urine as 4'-trans-hydroxy-Cilostazol. The remainder was excreted as other metabolites, none of which exceeded 5%. There was no evidence of induction of hepatic microenzymes.

The total and unbound oral clearances, adjusted for body weight, of Cilostazol and its metabolites were not significantly different with respect to age (50 to 80 years) or gender.

Population pharmacokinetic analysis suggests that smoking decreased Cilostazol exposure by about 20%.

The pharmacokinetics of Cilostazol and its metabolites were similar in subjects with mild hepatic disease as compared to healthy subjects.

Patients with moderate or severe hepatic impairment have not been studied.

The total pharmacologic activity of Cilostazol and its metabolites was similar in subjects with mild to moderate renal impairment and in healthy subjects. Severe renal impairment increases metabolite levels and alters protein binding of the parent. The expected pharmacologic activity, however, based on plasma concentrations and relative PDE III inhibiting potency of parent drug and metabolites, appeared little changed. Patients on dialysis have not been studied, but, it is unlikely that Cilostazol can be removed efficiently by dialysis because of its high protein binding (95 to 98%).

Cilostazol does not appear to inhibit CYP3A4.

Cilostazol did not inhibit the metabolism of R - and S-warfarin after a single 25 mg dose of warfarin.

Multiple doses of clopidogrel do not significantly increase steady state plasma concentrations of Cilostazol.

Strong Inhibitors of CYP3A4

A priming dose of ketoconazole 400 mg (a strong inhibitor of CYP3A4), was given one day prior to co-administration of single doses of ketoconazole 400 mg and Cilostazol 100 mg. This regimen increased Cilostazol C max by 94% and AUC by 117%. Other strong inhibitors of CYP3A4, such as itraconazole, voriconazole, clarithromycin, ritonavir, saquinavir, and nefazodone would be expected to have a similar effect [ see Dosage and Administration (2.2 ), Drug Interactions (7.1 ) ].

Moderate Inhibitors of CYP3A4

Erythromycin and other macrolide antibiotics: Erythromycin is a moderately strong inhibitor of CYP3A4. Co-administration of erythromycin 500 mg every 8h with a single dose of Cilostazol 100 mg increased Cilostazol C max by 47% and AUC by 73%. Inhibition of Cilostazol metabolism by erythromycin increased the AUC of 4´-trans-hydroxy-Cilostazol by 141% [ see Dosage and Administration (2.2 ) ].

Diltiazem 180 mg decreased the clearance of Cilostazol by

30%. Cilostazol C max increased

30% and AUC increased

40% [ see Dosage and Administration (2.2 ) ].

Grapefruit juice increased the C max of Cilostazol by

50%, but had no effect on AUC.

Inhibitors of CYP2C19

Omeprazole: Co-administration of omeprazole did not significantly affect the metabolism of Cilostazol, but the systemic exposure to 3,4-dehydro-Cilostazol was increased by 69%, probably the result of omeprazole’s potent inhibition of CYP2C19 [ see Dosage and Administration (2.2 ) ].

Concomitant administration of quinidine with a single dose of Cilostazol 100 mg did not alter Cilostazol pharmacokinetics.

The concomitant administration of lovastatin with Cilostazol decreases Cilostazol C ss. max and AUC τ by 15%. There is also a decrease, although nonsignificant, in Cilostazol metabolite concentrations. Co-administration of Cilostazol with lovastatin increases lovastatin and ß-hydroxylovastatin AUC approximately 70% and is not expected to be clinically significant.

Nonclinical Toxicology

Carcinogenesis, Mutagenesis, Impairment of Fertility

Dietary administration of Cilostazol to male and female rats and mice for up to 104 weeks, at doses up to 500 mg/kg/day in rats and 1000 mg/kg/day in mice, revealed no evidence of carcinogenic potential. The maximum doses administered in both rat and mouse studies were, on a systemic exposure basis, less than the human exposure at the MRHD of the drug. Cilostazol tested negative in bacterial gene mutation, bacterial DNA repair, mammalian cell gene mutation, and mouse in vivo bone marrow chromosomal aberration assays. It was, however, associated with a significant increase in chromosomal aberrations in the in vitro Chinese Hamster Ovary Cell assay.

Cilostazol did not affect fertility or mating performance of male and female rats at doses as high as 1000 mg/kg/day. At this dose, systemic exposures (AUCs) to unbound Cilostazol were less than 1.5 times in males, and about 5 times in females, the exposure in humans at the MRHD.

Animal Toxicology and/or Pharmacology

Repeated oral administration of Cilostazol to dogs (30 or more mg/kg/day for 52 weeks, 150 or more mg/kg/day for 13 weeks, and 450 mg/kg/day for 2 weeks), produced cardiovascular lesions that included endocardial hemorrhage, hemosiderin deposition and fibrosis in the left ventricle, hemorrhage in the right atrial wall, hemorrhage and necrosis of the smooth muscle in the wall of the coronary artery, intimal thickening of the coronary artery, and coronary arteritis and periarteritis. At the lowest dose associated with cardiovascular lesions in the 52-week study, systemic exposure (AUC) to unbound Cilostazol was less than that seen in humans at the maximum recommended human dose (MRHD) of 100 mg twice daily. Similar lesions have been reported in dogs following the administration of other positive inotropic agents (including PDE III inhibitors) and/or vasodilating agents. No cardiovascular lesions were seen in rats following 5 or 13 weeks of administration of Cilostazol at doses up to 1500 mg/kg/day. At this dose, systemic exposures (AUCs) to unbound Cilostazol were only about 1.5 and 5 times (male and female rats, respectively) the exposure seen in humans at the MRHD. Cardiovascular lesions were also not seen in rats following 52 weeks of administration of Cilostazol at doses up to 150 mg/kg/day. At this dose, systemic exposures (AUCs) to unbound Cilostazol were about 0.5 and 5 times (male and female rats, respectively) the exposure in humans at the MRHD. In female rats, Cilostazol AUCs were similar at 150 and 1500 mg/kg/day. Cardiovascular lesions were also not observed in monkeys after oral administration of Cilostazol for 13 weeks at doses up to 1800 mg/kg/day. While this dose of Cilostazol produced pharmacologic effects in monkeys, plasma Cilostazol levels were less than those seen in humans given the MRHD, and those seen in dogs given doses associated with cardiovascular lesions.

Clinical Studies

The ability of Cilostazol to improve walking distance in patients with stable intermittent claudication was studied in eight, randomized, placebo-controlled, double-blind trials of 12 to 24 weeks' duration involving 2,274 patients using dosages of 50 mg twice daily (n=303), 100 mg twice daily (n=998), and placebo (n=973). Efficacy was determined primarily by the change in maximal walking distance from baseline (compared to change on placebo) on one of several standardized exercise treadmill tests.

Compared to patients treated with placebo, patients treated with Cilostazol 50 or 100 mg twice daily experienced statistically significant improvements in walking distances both for the distance before the onset of claudication pain and the distance before exercise-limiting symptoms supervened (maximal walking distance). The effect of Cilostazol on walking distance was seen as early as the first on-therapy observation point of two or four weeks.

Figure 2 depicts the percent mean improvement in maximal walking distance, at study end for each of the eight studies.

Figure 2: Percent Mean Improvement in Maximal Walking Distance at Study End for the Eight Randomized, Double-Blind, Placebo-Controlled Clinical Trials.

Across the eight clinical trials, the range of improvement in maximal walking distance in patients treated with Cilostazol 100 mg twice daily, expressed as the percent mean change from baseline, was 28% to 100%.

The corresponding changes in the placebo group were -10% to 41%.

The Walking Impairment Questionnaire, which was administered in six of the eight clinical trials, assesses the impact of a therapeutic intervention on walking ability. In a pooled analysis of the six trials, patients treated with either Cilostazol 100 mg twice daily or 50 mg twice daily reported improvements in their walking speed and walking distance as compared to placebo. Improvements in walking performance were seen in the various subpopulations evaluated, including those defined by gender, smoking status, diabetes mellitus, duration of peripheral artery disease, age, and concomitant use of beta blockers or of calcium channel blockers. Cilostazol has not been studied in patients with rapidly progressing claudication or in patients with leg pain at rest, ischemic leg ulcers, or gangrene. Its long-term effects on limb preservation and hospitalization have not been evaluated.

A randomized, double-blind, placebo-controlled Phase IV study was conducted to assess the long-term effects of Cilostazol, with respect to mortality and safety, in 1,439 patients with intermittent claudication and no heart failure. The trial stopped early due to enrollment difficulties and a lower than expected overall death rate. With respect to mortality, the observed 36-month Kaplan-Meier event rate for deaths on study drug with a median time on study drug of 18 months was 5.6% (95% CI of 2.8 to 8.4%) on Cilostazol and 6.8% (95% CI of 1.9 to 11.5%) on placebo. These data appear to be sufficient to exclude a 75% increase in the risk of mortality on Cilostazol, which was the a priori study hypothesis.

How Supplied/Storage and Handling

How supplied

Cilostazol Tablets USP

The 50 mg tablet is supplied as a round, white, flat faced beveled edge tablet, debossed with product identification “54 521” on one side and plain on the other side.

NDC 0054-0028-21: Bottle of 60 Tablets

The 100 mg tablet is supplied as a round, white standard biconvex tablet, debossed with product identification “54 757” on one side and plain on the other side.

NDC 0054-0044-21: Bottle of 60 Tablets

NDC 0054-0044-29: Bottle of 500 Tablets

Storage and Handling

Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]

Patient Counseling Information

Advise the patient to read the FDA-approved patient labeling (Patient Information)

Advise the patient:

• to take Cilostazol at least one-half hour before or two hours after food. • to discuss with their doctor before taking any CYP3A4 or CYP2C19 inhibitors (e. g. omeprazole).

that the beneficial effects of Cilostazol on the symptoms of intermittent claudication may not be immediate. Although the patient may experience benefit in 2 to 4 weeks after initiation of therapy, treatment for up to 12 weeks may be required before a beneficial effect is experienced. Discontinue Cilostazol if symptoms do not improve after 3 months.

Distr. by: West-Ward

Eatontown, NJ 07724

Revised April 2016

PATIENT INFORMATION

Cilostazol Tablets USP

Read this Patient Information leaflet before you start taking Cilostazol Tablets USP and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.

What is the most important information I should know about Cilostazol?

Cilostazol can cause serious side effects:

• Cilostazol stops a protein called phosphodiesterase III from working. Other similar drugs which affect this protein may cause death if you already have heart problems, called class 3 to 4 (III-IV) heart failure. Do not take Cilostazol if you have heart failure of any kind.

What is Cilostazol?

Cilostazol is a prescription medicine used to reduce the symptoms of intermittent claudication and can increase your ability to walk further distances.

It is not known if Cilostazol is safe and effective for use in children.

How does Cilostazol work?

Improvement in symptoms may occur as soon as 2 weeks, but could take up to 12 weeks.

Who should not take Cilostazol?

Do not take Cilostazol if you:

• have heart problems (heart failure) • are allergic to Cilostazol or any of the ingredients in Cilostazol. See the end of this leaflet for a complete list of ingredients in Cilostazol.

Tell your doctor before taking this medicine if you have any of these conditions.

What should I tell my doctor before taking Cilostazol?

Before you take Cilostazol, tell your doctor if you:

• drink grapefruit juice. Taking Cilostazol and drinking grapefruit juice can increase the amount of Cilostazol causing side effects. • have any other medical conditions • are pregnant or planning to become pregnant. It is not known if Cilostazol will harm your unborn baby. • are breastfeeding or planning to breastfeed. It is not known if Cilostazol passes into your breast milk. You and your doctor should decide if you will take Cilostazol or breastfeed. You should not do both.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Ask your doctor for a list of these medicines if you are not sure. You can ask your pharmacist for a list of medicines that interact with Cilostazol. Know the medicines you take. Keep a list of them to show to your doctor and pharmacist when you get a new medicine.

How should I take Cilostazol?

• Take Cilostazol exactly as your doctor tells you to take it. • Your doctor will tell you how much Cilostazol to take and when to take it. • Your doctor may change your dose if needed. • Take Cilostazol 30 minutes before you eat or 2 hours after you eat.

What are the possible side effects of Cilostazol?

Cilostazol may cause serious side effects, including:

• heart problems. Taking Cilostazol may cause you to have heart problems, including a fast heartbeat, palpitations, irregular heartbeat, and low blood pressure. • see “What is the most important information I should know about Cilostazol?” • severe allergic reactions (anaphylaxis, angioedema). Call your doctor or go to the nearest emergency room right away if you have any of the following signs or symptoms of a severe allergic reaction: o hives o swelling of your face, lips, mouth, or tongue o trouble breathing or wheezing o dizziness • changes in your blood cell counts (thrombocytopenia or leukopenia). Your doctor should do blood tests to check your blood cell counts while you take Cilostazol.

The most common side effects of Cilostazol include:

• headache • abnormal stools • diarrhea

Tell your doctor if you have any side effect that bothers you or does not go away. These are not all the possible side effects of Cilostazol. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Cilostazol?

Store Cilostazol at room temperature between 20˚C to 25˚C (68˚F to 77˚F). [Store at USP Controlled Room Temperature.]

Keep Cilostazol and all medicines out of the reach of children.

General information about the safe and effective use of Cilostazol.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Cilostazol for a condition for which it was not prescribed. Do not give Cilostazol to other people, even if they have the same symptoms that you have. It may harm them.

This Patient Information summarizes the most important information about Cilostazol. If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information about Cilostazol that is written for health professionals.

For more information, call 1-800-962-8364.

What are the ingredients in Cilostazol?

Active ingredient: Cilostazol USP

Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate and microcrystalline cellulose.

This Patient Information has been approved by the U. S. Food and Drug Administration.

Distr. by: West-Ward

Eatontown, NJ 07724

Revised April 2016

PACKAGE/LABEL PRINCIPAL DISPLAY PANEL

PACKAGE/LABEL PRINCIPAL DISPLAY PANEL

Blood Pressure Buy Lasix At, Anfuramide

Blood Pressure

Lasix (Anfuramide)

Lasix is used for treating high blood pressure or water retention (swelling) associated with congestive heart failure, liver disease, or kidney disease. Lasix is a loop diuretic. Loop diuretics make the kidneys eliminate larger amounts of electrolytes (especially sodium and potassium salts) and water than normal (diuretic effect). Loop diuretics are useful for treating many conditions in which salt and water retention (eg, edema, swelling) are a problem.

Use Lasix as directed by your doctor.

Take Lasix by mouth with or without food.

If you take cholestyramine, colestipol, or sucralfate, ask your doctor or pharmacist how to take them with Lasix.

Lasix may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.

If you miss a dose of Lasix, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lasix.

Store Lasix at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat and moisture in a tight, light-resistant container. Exposure to light may cause a slight discoloration. Do not take discolored tablets. Do not store in the bathroom. Keep Lasix out of the reach of children and away from pets.

Active Ingredient: Furosemide.

Do NOT use Lasix if:

you are allergic to any ingredient in Lasix

you are unable to urinate

you are taking ethacrynic acid.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Lasix. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have fluid in your abdomen (ascites), hearing problems, liver disease, diabetes, low urine output, kidney problems, lupus, gout, abnormal blood electrolyte levels, high blood uric acid levels, or the blood disease porphyria

if you have had a heart attack, are dehydrated, or are on a low-salt diet.

Some medicines may interact with Lasix. Tell your health care provider if you are taking any other medicines, especially any of the following:

Corticosteroids (eg, prednisone) or corticotropin (ACTH) because the risk of low blood potassium levels may be increased

Barbiturates (eg, phenobarbital) or narcotics (eg, codeine) because the risk of dizziness upon standing may be increased

Aminoglycosides (eg, gentamicin), amphotericin B, angiotensin-converting enzyme (ACE) inhibitors (eg, captopril), cyclosporine, ethacrynic acid, tacrolimus, or vancomycin because serious side effects to the kidneys (decreased ability to urinate) or ears (hearing loss) may occur

Chloral hydrate because side effects, such as excessive sweating, rapid heartbeat, and changes in blood pressure, may occur

Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin) because they may decrease Lasix's effectiveness

Digoxin, lithium, medicines for high blood pressure, salicylates (eg, aspirin), or succinylcholine because the risk of their side effects may be increased by Lasix

Norepinephrine or tubocurarine because their effectiveness may be decreased by Lasix.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lasix may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Lasix may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Lasix with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Lasix may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Diabetes patients - Lasix may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Tell your doctor or dentist that you take Lasix before you receive any medical or dental care, emergency care, or surgery.

Your doctor may also prescribe a potassium supplement while you take Lasix. Check with your doctor before you use a salt substitute or other product that has potassium in it.

Lasix is a strong diuretic. Using too much of this drug can lead to serious water and mineral loss. Therefore, it is important that you be monitored by your doctor. Promptly notify your doctor if you become very thirsty, have a dry mouth, become confused, or develop muscle cramps/weakness.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.

Lasix may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Lasix. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Lab tests, including blood pressure and complete blood counts, may be performed while you use Lasix. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Lasix with caution in the elderly; they may be more sensitive to its effects, especially dehydration.

Caution is advised when using Lasix in children; they may be more sensitive to its effects.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lasix while you are pregnant. Lasix is found in breast milk. If you are or will be breast-feeding while you use Lasix, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Dizziness; lightheadedness; sensitivity to sunlight.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); calf pain or tenderness; confusion; dark urine; decreased or persistent increased urination; drowsiness; dry mouth; fast or irregular heartbeat; fever, chills, or sore throat; hearing decrease or loss; muscle pain/cramps/weakness; restlessness; ringing in the ears; severe or persistent nausea, vomiting, or dizziness; shortness of breath; sluggishness; stomach pain; unusual bleeding or bruising; unusual thirst or hunger; unusual tiredness or weakness; vein inflammation; yellow vision; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Frigates are the primary ships in the MiniSec universe. Able to do some damage and being quite hardy. They are also the only ship which can colonise an unpopulated planet.

The extra space taken up by the colonisation module means that there isn't much space left for the engines making frigates the slowest moving of all ships.

One Frigate is used for every planet colonised. For example, a fleet of 3 Frigates and 2 Battleships tries to colonise a planet. The fleet would now only have 2 Frigates and 2 Battleships.

Battleship

3 Units per turn

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Battleships are the largest and most hardy ship in the MiniSec universe. They have so much firepower that even when a draw occurs they are able to do some damage.

Battleships also have huge engines, which means even though they are much bigger and more armed than frigates they can move faster.

Planets

Colonised Planets can also participate in combat with anti-ship batteries. Each battery is equivalent to a battleship and can be destroyed separately. Planets behave exactly as multiple battleships except they are the last items to be targeted.

Normal planets are considered to be equivalent to 2 battleships . Home world planet (The planet you start with at the beginning of the game) is considered 5 battleships .

An example, when a planet suffers 6 HP of damage a battery is destroyed, this means that the amount of damage planet does on a win is reduced by 3HP (exactly like a one battleship being destroyed in normal battle).

When a planet loses a battle is becomes unpopulated.

Fleets

Ships are grouped together in Fleets. A ship by itself does not exist (but a Fleet with 1 ship in it can exist).

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Dopamine lack: I think restless leg syndrome is probably caused in susceptible people (tends to be familial) by a relative lack of sufficient Dopamine and is often associated with fatigue, dopamine-blocking medicines, chronic illness. and the end of gestation. Medications that increase Dopamine are frequently helpful as can be Neurontin (gabapentin ) and Klonopin (clonazepam ). . Read more

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Urge to move: irresistible, involves legs but may involve arms and trunk worse at rest relieved with movement (no symptoms during movement) but may recur once a person stops moving/walking worse in the evening or at night. . Read more

Triminulet, Triminulet

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Triminulet

Why register with MediGuard?

We are a free monitoring service designed for patients like you who want to be in the driver seat of your medical treatment. We have a community of more than 2.6 million members and offer the services below.

Medication Information Personalized Risk Rating Easy to understand overview Serious Side Effects Printable Medication List

Information you can understand Overview on Safety Alerts & Recalls Overview of Medications & Conditions

Community of patients Members’ Feedback Members Treatment Satisfaction

Health condition information Easy to understand overview Commonly Used Medications

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DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

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Amado Aceval Obituary, Aceval

Amado Aceval Obituary

Obituary

Aceval, Amado. March 17, 2016. Age 86 of Detroit. Husband of Maria. Father of Norma Aceval, Patricia Maldonado, Sandra Aceval, Korina Goertzen, Elizabeth Kelly, Alexander Aceval and the late David Aceval. Dear brother of Alicia, and the late Irma and Delores. Grandfather of 13. Great-grandfather of many. Visitation Tuesday, March 22, 2016 from 2- 9 p. m. at the Dearborn Chapel of Voran Funeral Home, 23701 Ford Road. (313) 278-5100. In state Wednesday 9:30 a. m. with a 10:00 a. m. Mass of the Resurrection to follow at St. Anne Catholic Church, 1000 St. Anne Street, Detroit. Interment St. Hedwig Cemetery. Visit our online guestbook and share memories at www. voranfuneralhome. com

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Services

Voran Funeral Home - Dearborn

23701 Ford Rd. Dearborn. MI 48128

Map / Directions

Visitation - Voran Funeral Home - Dearborn

Aceval, Amado Visitation - Voran Funeral Home - Dearborn 23701 Ford Rd. Dearborn, MI 48128

23701 Ford Rd. Dearborn, MI 48128

Tuesday, March 22, 2016 2:00 PM - 9:00 PM

1000 Ste. Anne Street Detroit. MI 48216-2027

Map / Directions

Service - St. Anne Parish

Aceval, Amado Service - St. Anne Parish 1000 Ste. Anne Street Detroit, MI 48216-2027

1000 Ste. Anne Street Detroit, MI 48216-2027

Wednesday, March 23, 2016 10:00 AM

St. Hedwig Cemetery and Mausoleum

23755 Military Road Dearborn Heights. MI 48127

Map / Directions

Cemetery - St. Hedwig Cemetery and Mausoleum

Aceval, Amado Cemetery - St. Hedwig Cemetery and Mausoleum 23755 Military Road Dearborn Heights, MI 48127

23755 Military Road Dearborn Heights, MI 48127

Wednesday, March 23, 2016

Flavoxate Side Effects In Detail, Flavonate

Flavoxate Side Effects

For the Consumer

Applies to flavoxate: oral tablet

In addition to its needed effects, some unwanted effects may be caused by flavoxate. In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking flavoxate, check with your doctor or nurse as soon as possible:

Rare

Confusion

eye pain

skin rash or hives

sore throat and fever

Symptoms of overdose:

Clumsiness or unsteadiness

dizziness (severe)

drowsiness (severe)

fever

flushing or redness of face

hallucinations (seeing, hearing, or feeling things that are not there)

shortness of breath or troubled breathing

unusual excitement, nervousness, restlessness, or irritability

Minor Side Effects

Some of the side effects that can occur with flavoxate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

Drowsiness

dryness of mouth and throat

Less common or rare:

Blurred vision

constipation

difficult urination

difficulty concentrating

dizziness

fast heartbeat

headache

increased sensitivity of eyes to light

increased sweating

nausea or vomiting

nervousness

stomach pain

For Healthcare Professionals

Applies to flavoxate: oral tablet

General

Flavoxate is generally well tolerated and an estimated frequency of particular side effects is not available. [Ref ]

Cardiovascular

Cardiovascular side effects have included tachycardia and palpitation. [Ref ]

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, and dry mouth. [Ref ]

Ocular

Ocular side effects have included increased ocular tension, blurred vision, and altered accommodation. [Ref ]

Nervous system

Nervous system side effects have included vertigo, headache, mental confusion, drowsiness, and nervousness. These effects may be exaggerated in elderly patients. [Ref ]

Renal

Renal side effects have included dysuria, and obstructive uropathies of the lower urinary tract. [Ref ]

Hypersensitivity

Hypersensitivity side effects have included urticaria and other unspecified dermatoses, eosinophilia, and elevated temperature. [Ref ]

Hematologic

Hematologic side effects have been reported rarely. A case of reversible leukopenia has been reported. [Ref ]

References

1. "Product Information. Uripas (flavoxate)." SmithKline Beecham, Philadelphia, PA.

2. Baert L "Controlled double-blind trail of flavoxate in painful conditions of the lower urinary tract." Curr Med Res Opin 2 (1974): 631-5

3. Delaere KP, Michiels HG, Debruyne FM, Moonen WA "Flavoxate hydrochloride in the treatment of detrusor instability." Urol Int 32 (1977): 377-81

4. Pedersen E "Studies on the effect and mode of action of flavoxate in human urinary bladder and sphincter." Urol Int 32 (1977): 202-8

5. Jarvis GJ "A controlled trial of bladder drill and drug therapy in the management of detrusor instability." Br J Urol 53 (1981): 565-6

6. Hebjorn S "Treatment of detrusor hyperreflexia in multiple sclerosis: a double - blind, crossover clinical trial comparing methantheline bromid (Banthine), flavoxate chloride (Urispas) and meladrazine tartrat (Lisidonil)." Urol Int 32 (1977): 209-17

7. Bradley DV, Cazort RJ "Relief of bladder spasm by flavoxate. A comparative study." J Clin Pharmacol J New Drugs 10 (1970): 65-8

8. Milani R, Scalambrino S, Carrera S, Pezzoli P, Ruffmann R "Flavoxate hydrochloride for urinary urgency after pelvic radiotherapy: comparison of 600 mg versus 1200 mg daily dosages." J Int Med Res 16 (1988): 71-4

Not all side effects for flavoxate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .

More about flavoxate

Consumer resources

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill. knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Drug Status

Bucoflam, Bucoflam

Bucoflam

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Arthritis - Bucoflam (Brand name: motrin)

Motrin is used for treating rheumatoid arthritis, osteoarthritis, menstrual cramps, or mild to moderate pain. Motrin is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Motrin as directed by your doctor.

Take Motrin by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Motrin with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Motrin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Motrin .

Store Motrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Motrin out of the reach of children and away from pets.

Active Ingredient: Ibuprofen.

Do NOT use Motrin if:

you are allergic to any ingredient in Motrin

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Motrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, lupus, asthma, or growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse.

Some medicines may interact with Motrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Probenecid because it may increase the risk of Motrin 's side effects

Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Motrin

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Motrin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Motrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Motrin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Motrin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Motrin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Motrin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Motrin has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Motrin unless your doctor tells you to.

Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Use Motrin with caution in the elderly; they may be more sensitive to its effects, including stomach bleeding and kidney problems.

Motrin should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Motrin may cause harm to the fetus. Do not take it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Motrin while you are pregnant. It is not known if Motrin is found in breast milk. Do not breastfeed while taking Motrin .

All medicines can cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Motrin is used for treating rheumatoid arthritis, osteoarthritis, menstrual cramps, or mild to moderate pain. Motrin is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Motrin as directed by your doctor.

Take Motrin by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Motrin with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Motrin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Motrin .

Store Motrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Motrin out of the reach of children and away from pets.

Active Ingredient: Ibuprofen.

Do NOT use Motrin if:

you are allergic to any ingredient in Motrin

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Motrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, lupus, asthma, or growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse.

Some medicines may interact with Motrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Probenecid because it may increase the risk of Motrin 's side effects

Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Motrin

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Motrin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Motrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Motrin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Motrin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Motrin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Motrin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Motrin has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Motrin unless your doctor tells you to.

Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Use Motrin with caution in the elderly; they may be more sensitive to its effects, including stomach bleeding and kidney problems.

Motrin should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Motrin may cause harm to the fetus. Do not take it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Motrin while you are pregnant. It is not known if Motrin is found in breast milk. Do not breastfeed while taking Motrin .

All medicines can cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Sildegra Generic, Sildegra

Sildegra

Sildenafil (Argentina, Australia, Austria, Belgium, Belize, Bosnia & Herzegowina, Brazil, Canada, Chile, China, Colombia, Congo, Costa Rica, Croatia (Hrvatska), Czech Republic, Denmark, Dominican Republic, Ecuador, El Salvador, Finland, France, Georgia, Germany, Greece, Guatemala, Honduras, Hong Kong, Hungary, Iceland, Indonesia, Ireland, Israel, Italy, Japan, Latvia, Lithuania, Malaysia, Mexico, Myanmar, Netherlands, New Zealand, Nicaragua, Norway, Oman, Panama, Peru, Philippines, Poland, Portugal, Romania, Russian Federation, Serbia, Singapore, Slovakia, Slovenia, South Africa, Spain, Sweden, Switzerland, Taiwan, Thailand, Turkey, United Kingdom, United States, Venezuela, Vietnam)

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Cadillac Elr Reviews - Cadillac Elr Price, Photos, And Specs - Car And Driver, Caldical

Cadillac ELR

Cadillac ELR

Car and Driver Car and Driver

2014 Cadillac ELR

Cadillac is betting that the stunning shape of its ELR coupe makes it worth twice the price of the Chevrolet Volt on which it's based. Is Caddy onto something, or just smoking something?

2016 Cadillac ELR Cadillac ELR 2016 3.0 1.0 5.0

From the February 2014 Issue of Car and Driver

The Cadillac ELR is a future pod, a show car made real. And it better look like a million bucks, because everybody’s going around calling it the $75,995 Chevy Volt.

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Yes, you read that correctly. The ELR’s entry price is nearly double that of the Volt, the Caddy’s mechanical starting point, and it’s roughly 2.5 times that of the average new car.

Hasn’t the Volt proven itself salesproof enough? Or does the ELR make an elegantly tailored and subversively creased argument that the Volt is actually too cheap? Is the Chevy’s primary failing that it doesn’t give the TED-talking, Google-glass-wearing, EV-driving set a suitably expensive way to prove how frugal they are? (See: Tesla.)

And as it turns out, this $80,000 Volt business is a bit of an overstatement anyway. The Cadillac is indeed based on the Chevy but shares very little with it except the 16.5-kWh battery pack and powertrain, and even those have software tweaks.

The floorpan is similar, but the suspension is all-new. It uses GM’s HiPer strut in front for better geometry, a Watt’s linkage for better lateral control at the rear, and variable dampers and power steering from ZF.

It’s longer than the Volt by 8.9 inches, wider by 2.3 inches, and lower by 0.7 inch, and it rides on a slightly longer wheelbase. The base of its windshield sits 6.3 inches forward of the Volt’s for that dramatic front rake, and not a single exterior piece is shared. So saying it’s just an $80,000 Volt is akin to asserting that the Cadillac XTS is a $45,000 Malibu. Which is true and also not true at all.

To the shared bits: What GM calls the Voltec powertrain is a confusing flowchart involving two motor/generators, three clutches, a planetary gearset, and a 1.4-liter four-cylinder. All you need to know is that there are two main propulsion modes: electric vehicle (EV) and extended range (ER). With a fully charged battery, the larger motor is limited to 157 horses and powers the front wheels through a fixed ratio. The second motor/generator, in conjunction with the planetary gears, can provide a ratio effect allowing the ELR to reach its 107-mph top speed in EV mode.

After draining the majority of its battery, the ELR automatically switches to ER mode and lights the engine. Most of the time the engine is turning the second motor/generator to provide electric juice, though there are times when the engine also delivers torque to the wheels. The drive motor makes 181 horsepower in ER mode; if the driver calls for it and there is enough battery, the ELR’s combined system will make up to 217 horsepower, a serious bump from the Volt’s 149.

Running as an EV, the ELR’s acceleration to 60 mph is 9.0 seconds, 0.2 second slower than the last Volt we tested because the 4054-pound ELR is nearly 300 pounds heftier. With its full 217 ponies saddled up, the ELR gets to 60 mph in 8.1 seconds and slips through the quarter-mile mark in 16.5 seconds at 87 mph, putting the ELR in a dead heat with a $16,000 Honda Fit. But the motor’s instantaneous torque will fool you into thinking it’s quicker.

Driven slowly, as the hybrid gods intend, the ELR is as smooth as two fingers of Lagavulin. The only clue that the engine has kicked over is a small change in the gauge cluster. The extra effort invested in the suspension—the shocks, the fancy struts, and the Watt’s linkage—pays off on wrinkled pavement and with increased pace. Even when the tires are close to falling off the grip cliff, at 0.84 g, the car responds to inputs better than any other front-drive hybrid on the road. The electric power steering is appropriately light and has zero slop, on-center and elsewhere.

What the ELR gives up in outright perform­ance, it gets back in efficiency. Unfortunately, EPA figures weren’t available at press time. Caddy says the numbers will be slightly lower than the Volt’s 98 MPGe in combined electric-only driving and 35 mpg city/40 mpg highway. We averaged 37 MPGe. Yes, that seems absurdly low for an often-electric car, but it includes nearly eight gallons of gas burned in ER mode coupled with a test distance of just 440 miles. Over the first 139 miles, we got nearly 80 MPGe. [See below for an MPGe primer.]

Miles per gallon equivalent (MPGe) is a unit of measure that allows for simple comparisons of the efficiencies of plug-in hybrids, electrics, and gasoline-powered cars by converting the energy in electricity to gallons of gasoline (the ratio happens to be 33.7 kWh to one gallon of gas). To determine the MPGe, use this equation:

But how to determine kWh used? Submetering a 240-volt circuit on your home panel is pricey, but if you only charge with 120-volt power, inexpensive usage monitors can be found at home-improvement stores.

The four driving modes are hold, mountain, sport, and tour. Added to the Volt last year, hold forces the ELR into extended-range driving. This maintains the battery’s charge and allows the driver to choose when and where to use the 30 or so miles of pure electric driving. It’s most useful on the highway, where aerodynamic drag depletes the battery as quickly as the Omega house drains a keg. Think of the ELR’s battery as a computer hard drive with two unequal partitions. The large partition is used for pure electric driving, and the smaller part is used for ER driving, the same way a regular hybrid uses its relatively small battery: constantly discharging and charging in the name of efficiency. In mountain mode, the smaller partition is temporarily increased. For the record, sport mode is mostly a novelty. It firms up the adaptive dampers, adds some heft to the steering, and quickens the accelerator pedal’s action.

The other unavailable EPA test result is EV range. When released, it should be close to 35 miles, or just three miles shy of the Volt’s. If, say, you live 22 miles from work and your commute includes 14 miles of 70-to-80-mph interstate traffic, you could conceivably drive to work, plug the ELR into a 240-volt source, and drive home without consuming a drop of gasoline.

Charging the ELR fully on a 120-volt source takes between 12.5 and 18 hours, depending on ambient temperature and energy flow. We found it charged overnight on a cold evening without a problem on 120. A 240-volt source will recharge a drained battery in five hours, according to Cadillac.

The ELR has what Cadillac calls “Regen on Demand,” which sort of mimics the way the Tesla Model S initiates regenerative braking every time its driver lifts off the throttle. Squeezing and holding either of the steering-wheel paddles triggers this function. It is either on or off, not progressive like a brake pedal, so there is a bit of a learning curve. Regen on Demand decelerates the car at a maximum of 0.20 g, with the brake lights illuminating at 0.12 g and above. At 0.20 g, an ELR would theoretically stop from 70 mph in about 800 feet, versus 173 feet (0.95 g) in a full-brake situation. But the ELR won’t come to a complete stop using only Regen on Demand.

With practice, you can drive around town with one pedal, using the paddles to engage regen and set up for 90-degree corners or otherwise manage speed. It makes mundane driving partially entertaining; you have to perfectly time it to avoid tapping the brakes. But we’d still rather have maximum regenerative braking when lifting off the accelerator, as in the Tesla.

The styling theme remained fairly static over the ELR’s gestation (the Converj concept that influenced this car made its debut at the 2009 Detroit auto show ), and with good reason: The envelope is beautiful and dramatic. It was determined that a low-volume, Volt-based Cadillac was a non-starter without 20-inch wheels, no matter how much their increased rotational inertia and 245-section-width tires hurt efficiency.

There?s no mistaking the ELR?s sumptuous, if somewhat busy, cockpit for that of the cheaply finished, iPod-inspired Chevy Volt.

Inside, the enormous dash has layers of material that look like stalled lava flows of carbon fiber, wood, suede, and leatherette. The $2450 Kona Brown leather seats come with adjustable thigh support and bolsters. Whether they’re worth the money is debatable, but the color is rich and contributes to an inviting, comfortable forecabin.

The back seat, however, is of little use to anyone eligible for a library card. Even a five-foot-six-inch adult must endure head-on impacts with the rear glass. Cargo capacity can be increased from the trunk’s nine cubic feet if you fold the rear seats, but the extra room isn’t as handy as you might think. The seatback splits 40-20-40, but the 20 part never moves—and not because of any need for body-stiffening structure. Rather, the fixed waterfall design element in the rear seat is strictly cosmetic, reducing the ELR’s practicality even more than its lack of rear headroom.

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Cadillac won’t say how many ELRs it hopes to sell. Judging by the price, it will be fairly limited, even if the tax rebates from the federal government ($7500) and some states (up to $7500) are attractive. Those with the means will love the ELR for the way it minimizes trips to the pump, satisfies a technology craving, and offers exclusivity. Is it worth it? Well, if you care about showing people how much you care about the environment while also showing them how much car you can afford, you will find that question very declasse.

Highs, Lows, and Verdict

Highs:

Otherworldly looks, placid ride, competent handling, high-tech powertrain.

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