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Ibuprofen is indicated for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis, mild to moderate pain, treatment of primary dysmenorrhea.

Hypersensitivity to the drug or in individuals with the syndrome of nasal polyps, angioedema, and bronchospastic reactivity to aspirin or other nonsteroidal anti-inflammatory agents. Anaphylactoid reactions have occurred in such patients.

Incidence greater than 1% (but less than 3%): Gastrointestinal: nausea, epigastric pain, heartburn, diarrhea, abdominal distress, nausea and vomiting, indigestion, constipation, abdominal cramps or pain, fullness of GI tract (bloating and flatulence). Central nervous system: dizziness, headache, nervousness Dermatologic: rash (including maculopapular type), pruritus Special Senses: tinnitus Metabolic/Endocrine: decreased appetite Cardiovascular: edema, fluid retention (generally responds promptly to drug discontinuation)

Coumarin-Type Anticoagulants, Aspirin, Methotrexate, H-2 Antagonists, Furosemide, Lithium.

General: Blurred and/or diminished vision, Fluid retention and edema. Liver effects: borderline elevations of one or more liver function tests may occur in up to 15% of patients. Severe hepatic reactions, including jaundice and cases of fatal hepatitis, have been reported. Hemoglobin levels: in cross-study comparisons with doses ranging from 1200 mg to 3200 mg daily for several weeks, a slight dose-response decrease in hemoglobin/hematocrit was noted. Aseptic meningitis: aseptic meningitis with fever and coma has been observed on rare occasions. Renal effects: there have been reports of acute interstitial nephritis with hematuria, proteinuria, and occasionally nephrotic syndrome. Since Ibuprofen is eliminated primarily by the kidneys, patients with significantly impaired renal function should be closely monitored; and a reduction in dosage should be anticipated to avoid drug accumulation.