Noperten Indication, Action Of Noperten, Interactions, Noperten


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Noperten [in more detail]

Noperten Indication:

For the treatment of hypertension, heart failure and acute myocardial infarction. It may be used alone or in combination with thiazide diuretics

Noperten Mechanism Of Action:

Noperten competes with angiotensin I for its binding site on the angiotensin-converting enzyme (ACE), an enzyme which converts angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II plasma levels result in decreased blood pressure and increased plasma renin activity. Baroreceptor reflex mechanisms, stimulated by the fall in blood pressure, release kininase II, an enzyme identical to ACE that degrades bradykinin, a vasodilator.

Noperten Drug Interactions:

Amiloride Increased risk of hyperkaliemia Triamterene Increased risk of hyperkaliemia Spironolactone Increased risk of hyperkaliemia Potassium Increased risk of hyperkaliemia Drospirenone Increased risk of hyperkaliemia Clozapine Increases the effect and toxicity of clozapine Lithium The ACE inhibitor increases serum levels of lithium Tizanidine Tizanidine increases the risk of hypotension with the ACE inhibitor

Food Interactions:

Avoid alcohol. Avoid excess salt/sodium unless otherwise instructed by your physician. Avoid salt substitutes containing potassium. Avoid natural licorice. Take without regard to meals.

Noperten Chemical Formula: