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Ch? D?nh

Gi?m dau, h? s?t va tang cu?ng s?c d? khang trong cac tru?ng h?p: – S?t do chich ng?a, c?m l?nh, c?m cum, viem h?ng, viem xoang do nhi?m khu?n hay th?i ti?t,… – Dau d?u, dau tai, dau rang, m?c rang, nh? rang, dau do ch?n thuong, sau ph?u thu?t c?t amidan,…

Dong goi

H?p 24 Goi x 1,5mg Thu?c b?t s?i b?t

Cong th?c

– Paracetamol. 150 mg – Vitamin C. 75 mg – Ta du?c. v?a d? 1 goi (Acid citric khan, Sodium bicarbonate, Mannitol, Saccharin, Sodium benzoate, Povidone, Mau Erythrosin dye, Mau Violet dye, B?t huong cam, Ethanol 96%, Du?ng RE)

Du?c l?c h?c

– Paracetamol la thu?c gi?m dau – h? s?t khong gay nghi?n, khong ch?a salicylat, co tac d?ng gi?m dau ngo?i vi. Thu?c lam tang ngu?ng ch?u dau ? cac ch?ng nh?c d?u, dau co, dau kh?p va cac tri?u ch?ng kho ch?u khi b? c?m cum. Paracetamol lam gi?m than nhi?t ? ngu?i b?nh s?t, nhung hi?m khi lam gi?m than nhi?t ? ngu?i binh thu?ng. Thu?c tac d?ng len vung du?i d?i gay h? nhi?t, t?a nhi?t tang do gian m?ch va tang luu lu?ng mau ngo?i bien. – Vitamin C tham gia vao cac qua trinh chuy?n hoa, t?ng h?p cac ch?t c?n thi?t cho co th? va gi? vai tro quan tr?ng trong tang cu?ng ch?c nang mi?n d?ch, tang kh? nang d? khang v?i nhi?m khu?n c?a co th?. PARACOLD KIDS ch?a 150 mg Paracetamol va 75 mg Vitamn C, du?c bao ch? du?i d?ng thu?c b?t s?i b?t, hoa tan trong nu?c tru?c khi u?ng, thich h?p dung h? s?t – gi?m dau – tang cu?ng s?c d? khang cho tr? em.

Du?c d?ng h?c

? Paracetamol: H?p thu nhanh chong va h?u nhu hoan toan qua du?ng tieu hoa. N?ng d? d?nh trong huy?t tuong d?t trong vong 30 – 60 phut sau khi u?ng v?i li?u di?u tr?. Phan b? nhanh va d?ng d?u trong ph?n l?n cac mo c?a co th?, qua du?c nhau thai va s?a m?. Kho?ng 25% Paracetamol trong mau k?t h?p v?i protein huy?t tuong. Th?i gian ban th?i t? 1 – 3 gi?. Paracetamol chuy?n hoa ? gan thanh ch?t trung gian N – acetyl – benzoquinonimin co th? gay d?c gan. Thu?c dao th?i ch? y?u theo du?ng ti?u trong vong 24 gi? du?i d?ng s?n ph?m chuy?n hoa (ch? m?t lu?ng nh? ? d?ng khong d?i). ? Vitamin C: H?p thu d? dang sau khi u?ng va phan b? r?ng rai trong cac mo co th?. Kho?ng 25% Vitamin C trong huy?t tuong k?t h?p v?i protein. Vitamin C oxy – hoa thu?n ngh?ch thanh acid dehydroascorbic. M?t it Vitamin C chuy?n hoa thanh nh?ng h?p ch?t khong co ho?t tinh g?m Ascorbic acid – 2– sulfat va acid oxalic du?c bai ti?t trong nu?c ti?u. Lu?ng Vitamin C vu?t qua nhu c?u c?a co th? cung du?c nhanh chong dao th?i ra nu?c ti?u du?i d?ng khong bi?n d?i.

Ch?ng ch? d?nh

– M?n c?m v?i Paracetamol. – Ngu?i b?nh nhi?u l?n thi?u mau ho?c co b?nh tim, ph?i, th?n, suy gan. – Ngu?i b?nh thi?u h?t glucose – 6– phosphate dehydrogenase. – Ngu?i co ti?n s? s?i th?n, tang oxalat ni?u va lo?n chuy?n hoa oxalat, b?nh thalassemia.

Tac d?ng ph?

– Hi?m g?p cac tai bi?n d? ?ng nhu ban d?, n?i m? day. Ngung dung thu?c khi th?y xu?t hi?n cac bi?u hi?n nay. – Dung li?u cao va keo dai co th? gay t?n thuong ? gan. – Vai tru?ng h?p hi?m th?y gi?m ti?u c?u. – Li?u cao Vitamin C co th? gay tieu ch?y, bu?n non, non, ? nong, nh?c d?u, m?t ng?, tang oxalat ni?u, thi?u mau tan huy?t. Thong bao cho bac s? nh?ng tac d?ng khong mong mu?n g?p ph?i khi s? d?ng thu?c. QUA LI?U: – Qua li?u Paracetamol co th? do dung m?t li?u cao duy nh?t, ho?c do u?ng l?p l?i li?u cao Paracetamol (7,5 – 10g m?i ngay, trong 1 – 2 ngay), ho?c do u?ng thu?c dai ngay. Ho?i t? gan la tac d?ng d?c c?p tinh nghiem tr?ng nh?t do qua li?u va co th? gay t? vong. Bu?n non, non va dau b?ng thu?ng x?y ra trong vong 2 – 3 gi? sau khi u?ng li?u cao c?a thu?c. Qua li?u Vitamin C gay s?i th?n, bu?n non, viem d? day va tieu ch?y. – X? ly: + C?n r?a d? day trong m?i tru?ng h?p, t?t nh?t trong vong 4 gi? sau khi u?ng va di?u tr? h? tr? tich c?c. + S? d?ng thu?c gi?i d?c: N – acetylcystein, Methionin. + Ngoai ra co th? dung than ho?t va/ho?c thu?c t?y mu?i d? lam gi?m h?p th? Paraceamol.

Th?n tr?ng

– Paracetamol co th? gay cac ph?n ?ng tren da nghiem tr?ng nhu h?i ch?ng Steven – Jonhson (SJS), h?i ch?ng ho?i t? da nhi?m d?c (TEN) hay h?i ch?ng Lyell, h?i ch?ng ngo?i ban m?n m? toan than c?p tinh (AGEP). – Th?n tr?ng khi s? d?ng Paracetamol cho ngu?i b?nh thi?u mau t? tru?c. – Khong u?ng ru?u khi dung thu?c. – Dung Vitamin C vao bu?i t?i va li?u cao co th? gay kho ng?. – Tru?ng h?p an kieng mu?i c?n luu y thu?c co ch?a 95,1mg Na trong 1 goi. – N?u tri?u ch?ng dau dai d?ng qua 5 ngay, ho?c con s?t qua 3 ngay, ho?c thu?c chua d? hi?u qu?, ho?c th?y xu?t hi?n cac tri?u ch?ng khac, khong nen keo dai vi?c t? s? d?ng thu?c ma khong h?i y ki?n bac s?.

Tuong tac

– Isoniazid, Alcool, cac thu?c ch?ng co gi?t (Phenytoin, Barbiturat, Carbamazepin) co th? lam gia tang nguy co d?c gan gay b?i Paracetamol. – Dung chung Phenothiazin v?i Paracetamol co th? d?n d?n kh? nang gay h? s?t nghiem tr?ng. – Metoclopramid co th? lam gia tang s? h?p thu c?a Paracetamol. – Vitamin C la m?t ch?t kh? m?nh, nen ?nh hu?ng d?n nhi?u xet nghi?m d?a tren ph?n ?ng oxy hoa – kh?. S? co m?t Vitamin C trong nu?c ti?u lam tang gi? t?o lu?ng glucose n?u d?nh lu?ng b?ng thu?c th? d?ng (II) sulfat va gi?m gi? t?o lu?ng glucose n?u d?nh lu?ng b?ng phuong phap glucose oxydase.

H?n dung

2 nam k? t? ngay s?n xu?t

B?o qu?n

Noi kho (d? ?m ? 70%), nhi?t d? khong qua 30 o C, tranh anh sang

Cach dung

Hoa tan thu?c vao lu?ng nu?c (thich h?p cho be) d?n khi s?i h?t b?t. Kho?ng cach gi?a cac l?n dung thu?c t? 4 – 6 gi?, khong qua 5 l?n/ngay. Li?u thong thu?ng t? 10 – 15 mg/kg/l?n va 60 mg/kg/ngay. – Tr? em tren 3 d?n 11 thang tu?i: u?ng 1/2 goi/l?n. Ngay 3– 4 l?n. – Tr? em tren 11 thang d?n du?i 2 tu?i: u?ng 3/4 goi/l?n. Ngay 3– 4 l?n. – Tr? em t? 2 d?n 3 tu?i: u?ng 1 goi/l?n. Ngay 3– 4 l?n. – Tr? em tren 3 d?n 6 tu?i: u?ng 1,5 goi/l?n. Ngay 3– 4 l?n. – Tr? em tren 6 d?n 9 tu?i: u?ng 2 – 2,5 goi/l?n. Ngay 3– 4 l?n. – Tr? em tren 9 d?n 12 tu?i: u?ng 3 goi/l?n. Ngay 3– 4 l?n. Ho?c theo ch? d?n c?a th?y thu?c.

Tieu chu?n

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