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Darkness At Sunset And Vine, Dasav

After attending our production of Darkness at Sunset and Vine at UNT, Ginger Mayerson had the following comments on the adaptation and on her motivations for writing her novella:

I'd like to thank Kelly Taylor for bringing my very angry novella to life and commend her and her squad, because they're performance commandos, really, for breathing life into my work as if with a flamethrower. That said, I can only add that Nellie Gail is considerably grander when she's standing three feet in front of one than smoldering on the page. I thoroughly commend Messrs. Calvert, Wood, Thompson, Wilkerson, Badger, and Notebloom for the massive amounts of thoughts, charm and brute force energy they put into the production.

And a special salute to Andrea Baldwin, who fearlessly took on the role of the most genial sociopath in all of dystopian Los Angeles and powerfully portrayed the bleak wry weary minimalist humanity I wrote into Nellie Gail that could have been lost so easily in all the blood and horror of the story. Andrea portrayed Nellie as a woman who could stare down genocide with ruthless and fearless intelligence. As that man said, more or less, whoever fights monsters should take care they become a monster. Of course Nellie, via Andrea, stands that on its head by becoming less of a monster when she decides to start fighting them. A hearty thank you to all of you for blasting Darkness at Sunset and Vine off the page and into the wider world.

Andrew Calvert, Adam Wood, Chandler Thompson, Jay Wilkinson, as actors, and Kevin Badger, and Kris Noteboom in more technical roles, did an exceptional job supporting the story and keeping things moving. I know very little about co-operative directing, but I do know a good ensemble when I see it. The lads ran rings around the stage, being wherever they needed to be to support the story or add a dash of color, with Kevin Badger neatly demarcating the sections, giving the actors a moment to catch their breath and then be off like rockets again. If they were in a jazz ensemble, they'd be a saxophone choir: soloing here and there, but usually supporting the harmonic structure and each other in the middle ground. An example of that in the performance was that every time Nellie goes to her place, there's a new permutation of weirdoes waiting for her and Drew, Adam, Chandler, and Jay completely made each weirdo weirdly distinct and then some. The ensembles and solos came together, dispersed, reformed, and the cycle was repeated again and again with discreet tones, textures and rhythms that were rich in variety and saturated with powerful semiotics. I never felt that I was looking at the same guy twice, or gal, as in Sara Lee's case.

Sara Lee's character was devised in haste and partly for a throw away joke, but she really came alive with Adam Wood's homicidal budding linguist camp performance. He only has her up for less than a minute, and yet she was as fully formed as if she'd sprung like Athena. But earlier in the show, Adam plays the second villain, Mr. Glen, with a drawl and a snarl which ought to be a word like, dranarl or snrawl or something, and he gets more syllables than I ever thought possible out of words like bullshit, which is bu-ul-shi-eet by the time he finally gets through with it. Impressive, most impressive. As I recall, he gives an amazing performance sitting down, merely twisting his body up at Nellie while twisting his words and human decency as well. When he does spring up, it's to shoot S. Crow in a way that looks like two teenagers humping in the backseat of a car. Really; it's on video and everything. I don't know what that blocking started out as, but that's what it looked like by the last show. Too bad there couldn't have been a few more performances, like a dozen, to see how far those moves could have gone. But, oh well, what might have been, saddest words, etc.

The character of S. Crow flies by in the novella, but he gets a star turn and an over-the-top death in this production. Andrew Calvert is, from the first moment he speaks to Nellie, the jittery emaciated heavily armed scarecrow of a man I wrote. I only saw two nights, but, as I mention above, when Glen kills him, it becomes more and more lewd with the two of them bumping around on the floor. It's one of the funnier deaths in the whole show, if you can wrap your mind around that.

Andrew also rocks the house as Dr. Max, the exiled economist freedom fighter who lays it on the line with Nellie about Fydor Chandler and the good of the many vs. the good of the one and how that might be the same thing in this instance. Andrew plays Max as the only person in the story who really realizes how dangerous and amoral Nellie is, and yet he is also the only person who finds some finer feelings in Nellie to appeal to. He takes a tremendous risk in asking her to do the right thing in all the insanity that surrounds them both. In the novella, Max's cohort stays passively in the background. In the production they are nervously circling the unarmed Nellie and being reminded by Max that they're all on the same side. Andrew plays Max as a man with a larger purpose than just his survival, one of the few characters with any vision, but as a man who is going to survive to see his vision realized. He explains to Nellie the danger she's in and then mocks her gently, goading her into the right frame of mind without preaching, something she'd kill him with her bare hands and acid irony for. Andrew put Max's shrewd wisdom across the footlights with a combination of the power in his voice and a certain air of nervousness that worked better than the confident sneer he'd had on paper. Andrew played Max as a guy who can't fail, because if he does, nothing much will matter anymore. He has to make sure Nellie knows that, and Andrew really got that message across to all of us.

Jay Wilkinson aced putting some fire and dimension in Rush, just call me Rush, one of the colder, flatter villains in the story. A man so sure of his lofty status he can't be bothered to give anyone his real name. As a villain, Rush must project entitlement, condescension, rage and arrogance at the same time. Jay managed to do all those things while almost dancing to the rhythm of his delivery. Rush is a desperate man under the expensive tailoring, as if his WASP male privilege was eating him from the inside out while he is trying to hold onto the last vestiges of it. Much of what Jay had to do as Rush, and did very well, was project menace and cruelty with his voice and posture without wrinkling the suit one could almost see he was wearing. It was eerie how much ghostly sartorial semiology was going on in that performance. Some actors let their costumes do their acting. Somehow Jay got the audience to imagine his costume, which was a very sharp ensemble, but didn't let it get in the way of his acting. Weird, deeply weird it was, but effective if I'm still thinking about it.

Chandler Thompson gets a double-wide gold star for playing two Mayersonian villains. He played Sara Lee's father, Mr. James, with exactly the right mix of sick fatherly concern and menace. With Mr. James, Chandler set the tone for what's left of the debased US government and the sleazy characters yet to come. His second villain was Kevin, whom he played as a demented drooling monster. I thought his portrayal was effective and humorous, but not what I had thought it would be. The Kevin in my head is an icy, soulless bureaucrat, the kind of guy who signs a requisition for mass murder, terror, and pillage as easily as he orders lunch. Actually all my villains are, on paper, a little colder and deader than they were in this production, but what goes on in my head wouldn't make good theater even on a good day. I laughed very much at the interaction between Kevin and Rush, who is justifiably terrified of him. Chandler also portrayed the Tiny Gun Man who works for Dr. Max. TGM's job is to keep his tiny gun on Nellie, who menaces him and smacks his gun away repeatedly. Chandler's wordless performance is brilliant as a man with one job, however silly, that he's going to do well or die in the effort.

There are too many good moments to pick out of this production and obsess on. I've hit the ones that have stayed with me nearly two months later, which says a lot about their impact and staying power. Everyone in this cast did an outstanding job of soloing and supporting and they did it with more grace and brio than I could have imagined possible in the blood-soaked nihilist wasteland of Darkness at Sunset and Vine .

I can't really express how moved I was seeing my writing come to life before my very eyes and ears. Moved, touched, pleased, frightened, startled, delighted, and occasionally a little freaked out only touches on part of what I felt in Denton last April. I think I should mentions the one thing that freaked me out the most and has stayed with me in many ways was the suicide bomber scene. It was a perfect fit into the visual narrative of this production, absolutely letter-perfect. But I didn't write it and I didn't realize how much I'd subconsciously shied away from that particular idea until I saw it. In fact, my mind refused to see it until the second performance when what I thought I saw in the first and didn't ask about afterwards was, well, really what I saw. An American Suicide Bomber in pantomime, which didn't make it any less disturbing for me. I'm here to tell ya, it was a very powerful theatrical device, maybe too powerful. Our own people resorting to suicide bombing as the ultimate protest against an unjust government would be the end for the United States as we know, even the fucked up version we have now, it would really be over. Even I have some hope the will to revive the Constitution, that piece of paper of ideas so many have died for, even I have some faith that our country can pull itself together again and become a place where life gets better, or at least not worse, every generation. Even though I believe the best future is for the United States to break up regionally and ideologically, I deeply hope this can happen without the horror of homegrown suicide bombers in the streets. And, frankly, I hope I'm dead before my county reaches the level of despair, desperation and hopelessness that sends young men and women into the streets to kill as many people as possible and themselves with a bomb strapped to their body. The United States as we know it and hope for it to be again, will truly be finished when suicide bombing becomes the only means, however futile and tragic, of striking back at the power structure. When terror, terror by the State or by citizenry, replaces all mechanisms of dissent, dialogue and change, (I'm sure democracy will be long gone by then) there will be no place for people like me in the United States. There will be nothing that resembles what the United States once was or could be or even dreamed it could be. And I suspect that historians will date the beginning of the dream's end in the last month of the last year of the last century.

My life changed rather unpleasantly on December 12, 2000. I had, up until that moment, really thought that what was good about our political process was unshakable, or at least had some merit. Perhaps only my faith in it was unshakable. When the Supreme Court stopped the Florida recount in a vote strictly on partisan lines, is was disgusted that they'd not only disenfranchised Florida voters, they'd disenfranchised the entire country. Whey they tell you "your vote matters" they're not talking about the 526 votes Gore didn't get due to the butterfly ballot, Nader, voter intimidation, sunspots, gremlins, Katherine Harris, whatever. What they mean is your vote matters. if you're a Supreme Court Justice. Yes, I was bitter, I was outraged, I argued with anyone who'd take me on, I was reading the papers, the blogs, and Vincent Bugliosi's most excellent book None Dare Call It Treason. where the future of Bushco lawlessness is subtly predicted in the explanation of the majority Court's psychotic reactionary disregard for the Democratic process by stopping the recount. (Dear God, we just wanted all the votes counted properly so we could know, really know, but no, 5-4 gets to decide, and now look at us.) But I still thought our government had enough checks and balances, or enough goodness left in it to honor those checks and balances, to plod along with four years of the bush junta. Of course all that changed on September 11, 2001 when, with the notable exception of Congresswoman Barbara Lee of Oakland, California, our Congress handed 200+ years of more or less democracy into the keeping of the spoiled scion of an amoral family headed by a guy who was born on 3rd base but thought he'd hit a triple, as a witty Texan once said. Alas, I was not laughing: I had never been afraid of my government. until then.

I am not a conspiracy theorist, I really cannot stand those people. But in the shock of events on September 11, 2001, two things went through my mind: 1) something designed to get our minds off what a fuck-up Bush II was/is, something to scare us a little, shake us up a bit got away from the Bush family and its mafia and scared us a lot; and 2) Jesus, we got the fucking worst possible government in DC at this moment for this to have happened. And when we had the sympathy and support of most of the world, when a meaningful and concerted effort to rid the world of terrorism could have been put into action, GW Bush told the world to fuck off: he was doing it his way and his way involved bombs, bombs, bombs, more bombs, and getting the Bin Laden family out of the US on special planes when everything else was grounded. And if anything in this whole perverted mess makes me weep, it's the lost opportunity that evil idiot threw away.

By 2003, I was blogging as fast as I could if only to verify what I knew was true and right before it disappeared down the memory hole. Blogging might be a joke now, but in 2003 in was a way to stay sane in all the war madness. I know I was against and I know why and it's all on my blog. Being an amateur historian has its ups and downs, but only a complete idiot could possibly think invading Iraq was a good idea. And only sick, demented monsters like GW Bush, Cheney, and Rumsfeld could call murdering civilians Shock and Awe. Yes, murdering civilians, blowing the limbs off young boys, wiping out entire families, and all from the safety of their offices where they made the worst decision in the history of the United States. My country, my people, my history will never get the blood off its hands in my lifetime, if ever.

I wish I had been being overly dramatic. I had no idea just how bad it was going to get.

On September 7, 2003 President Bush lied to us again:

"Our strategy in Iraq will require new resources. We have conducted a thorough assessment of our military and reconstruction needs in Iraq, and also in Afghanistan. I will soon submit to Congress a request for $87 billion. The request will cover ongoing military and intelligence operations in Iraq, Afghanistan and elsewhere, which we expect will cost $66 billion over the next year. This budget request will also support our commitment to helping the Iraqi and Afghan people rebuild their own nations, after decades of oppression and mismanagement. We will provide funds to help them improve security. And we will help them to restore basic services, such as electricity and water, and to build new schools, roads, and medical clinics. This effort is essential to the stability of those nations, and therefore, to our own security. Now and in the future, we will support our troops and we will keep our word to the more than 50 million people of Afghanistan and Iraq."

That night in 2003, as I read to this speech on my computer, I could not know that over 100K Iraqis would die, that Abu Ghraib would question my faith in our military and humanity, that billions would go missing somewhere between Halliburton and, well, Halliburton. I could not know over four thousand American soldiers would die in the service of a government that was unworthy of their sacrifice, I could not know the America I was raised to love would promote torture, despotism, fear, greed, slavery, rape, murder, and more murder for the goals of one small group of men who'd come to power, legally or not, but who'd taken the tragic opportunity of September 11 to sweep away any moral or legal obstacles to their plans to rule through fear, because they cannot govern through consent. And so they did. And so they continue to do so. Monstrous men - Cheney, Bush and Rumsfeld - and their minions not much less monstrous than themselves.

But that night in September 2003 I could not know any of this, I could only go cold with rage and fury that the moral and fiscal consequences of Bush's murderous Iraq invasion were going to sow horror in my country for generations and that it was so fucking unnecessary. I was too angry to cry, to furious to move, and the only thing I could do was open a word processing window and pound out the first five thousand words of Darkness at Sunset and Vine. DASAV is 20K words. I wrote it in five days and somehow managed to work my 9-5 job as well. This story poured out of me in a torrent of fury and sorrow in between bouts of pounding on my desk and howling with rage. I am not a patriot. I love my country because its mine. I hadn't realized how much I love it and writing a story might not seem like much of a fight for something one loves, but it was the only fight I had in me at that moment. Even a California girl will turn and fight with whatever is at hand when her back is against the surf. And this is how I felt in September 2003. Five years later, I've calmed down a little, but I've only banked my fire with hope and sadness, it could flare up again with the right provocation (and, yes, I am looking at the White House as I write that, and will be looking at it, hard, until Jan 20, 2009 supposing there isn't another "terrorist" event and Bush doesn't declare himself President for Life).

At the time I was writing DASAV. my beloved California, for various insane and greedy reasons, was in the throes of recalling Governor Gray Davis, an unlucky and mediocre bureaucrat. Maybe I was just kidding myself, but at the time it seemed like the recall could go either way and DASAV was written as if Davis had won the recall, but the Bush family sent troops into California to install Schwarzenegger as governor. Would Californians fight this kind of invasion? For the purposes of fiction, I said yes, but looking around at the suckers like Darryl Issa and the clowns who elected Schwarzenegger, twice yet, I wonder. At one point in the second novella, The End of History at Sunset and Vine. Nellie's dinner date (yeah, I know, Nellie on a date, laugh riot, right?) opines that he didn't like what happened to his State. Nellie politely refrains from saying out loud that she thinks her State got what it deserved. It's too long and complicated to go into in this screed, but through overuse of the referendum mechanism, which means we vote more than Switzerland, a manipulative, if not malevolent business culture and media, and just being stupid and greedy, California has bankrupted its government, painted itself into a corner, tied its hands, and knocked over a candle to set the house on fire, which the under-funded emergency services aren't going to get to in time. But, hey, dude! Arnold Schwarzenegger is our governor, and the only thing that stands between our citizenry and complete moral, physical and financial collapse is the California Nurses Association and a couple of unions. But, hey, dude! Arnold Schwarzenegger is our governor, and - oh, just fucking, never mind.

The Enron scandal was also a factor in Governor Davis' downfall, that wasn't clear to most people until after he was ousted. Most people still think he was a big loser because he couldn't control energy prices and, in truth, he couldn't control them under the deregulated system most of California adopted in the mid 90s, led by Republican governor Pete Wilson, who governed under some kind of powerful curse so that California experienced nothing but catastrophe after disaster, including, but not limited to, earthquakes, weeks of wildfires, urban rioting, and energy deregulation, during his terms in Sacramento. Although Dr. Taylor's production did not feature my concept of power, who had it and why, in post-Occupation Los Angeles, I wrote quite a bit on how LA and parts of the State I liked might survive through the good management of a few farsighted individuals and the brute force and street smarts of the rest of the citizens determined to stay in town. The fate of Los Angeles and California were very much on my mind in the aftermath of the Enron free-market assault on my foolish State. During the 90s energy deregulation madness in California, the head of the Los Angeles Department of Water and Power, Mr. David Freeman, refused to deregulate our utilities. It was not mandatory and, being an intelligent man who could remember longer than last week and might have done some reading on the history of unrestrained capitalism, he could see deregulating a vital service was not just a bad idea, it was a really fucking stupid idea. So he refused to do it. Our DWP has flaws, but deregulation is not one of them. This is why the DWP is keeping the lights on and the water flowing and raking a percentage off the top of every dollar circulating on the net in the City of Angels in 2016. How would they do it? They'd hire thugs like Nellie to protect their aqueducts and power stations, as well as dig up alternative energy sources that were getting dusty through disuse. The original El Pueblo de Nuestra Se?ora la Reina de Los Angeles de Porci?ncula founded in 1781 had (and likely still has) enough water to support about 14,000 souls. The Los Angeles Nellie lives in is about that number or less, and I surmised that the DWP could find a way to support that many paying customers with electricity and water. In the later novellas, I expound on the Metropolitan Transit Authority's role in policing their bus routes and how AT&T keeps the internet working, but nearly destroys everything in a further grab for power.

DASAV is set in Los Angeles after the Federal Occupation which resulted in Der Terminator, sorry, Der Schwarzenegger, being installed as Gov for Life. I was discussing this with a friend in Michigan, who said LA would be impossible to occupy. This is likely true, but, courtesy of Bush 1, we have had US Marines patrolling the streets of South Central LA after the 1992 Rodney King Rebellion, so troops on the street isn't just a possibility in America, it has been a reality in Los Angeles. You see, here in Hollywood, we don't just live our dreams, we live our nightmares, too.

Much of the novella DASAV concerns how things got so messed up. That the goals of the Bush family and their mafias was to create a passive slave society (through drugs, terror, and starvation, physical and spiritual) in which their looting could go unimpeded. Most of the American intelligencia has fled. Philanthropic George Soros and opportunistic Bill Gates have essentially purchased Mexico as a haven for anyone smart enough to get there in time. (Canada has sensibly closed and mined their border with the US, but do help out in the third novella.) It is in Mexico, as brilliantly administered by economists Paul Krugman and Jeffery Sacks, that economists, scientists, linguists, and other such brainy and advanced-degrees types have been formulating plans to retake their country. The technology sector that has fled with the brain trust has been manufacturing and exporting the sexy ti-tandex outfits Nellie wears for protection and the titanium Colt she packs for action. Within the United States, Nellie's former colleague, the brilliant linguist and vicious urban tactician (or vicious linguist and brilliant urban tactician, either way) Fydor Chandler, has been leading a guerilla resistance, but the strain is driving him mad. Nellie's idol, Dr. Max of Dr. Max's Live Nude Economics - the best show on the Internet Broadcast - currently exiled in Mexico, comes to Nellie to ask her to convince Fydor to lead his people to join forces with Max in Mexico. It is Nellie's history with Fydor that leads Max to believe she might be able to convince him with emotion where mere reason would fail. Among Fydor's followers is the fantastically idealistic and tragically young Sara Lee, who has shrewdly taken a member of the Bush family hostage in a serious blow against their authority. It's Sara Lee's action that triggers all the events that ultimately lead to Nellie ending up if not on the right side of history, at least on the right side of what's left of her conscience.

Okay, I get this question a lot: Why are all the freedom fighters linguists?

Oh, why not? Just because one never sees a linguist with a rocket launcher doesn't mean it couldn't happen. Why should rhetoricians have all the fun?

There are two more novellas in the trilogy: The End of History at Sunset and Vine. wherein Chelsea Clinton is coming to LA to lead the revolution. Yay? The Greens, the Christian Right, and Kevin, the evil functionary from part 1 are trying to destroy what's left of the US, starting with Nellie and Los Angeles. In part 3, A New American Century at Sunset and Vine. the bad guys this time are working directly for the Bush family and their mafias using Fundamentalist Christian Rightwing refugees as human shields to get the Bush family and their money out of the US before the whole mess implodes. Also in this final story, Nellie and Fydor learn some important things about LA infrastructure, spend some quality time in a underground library cum bunker, Chinatown, and Nellie meets the followers of the cult of Santa Gloria Molina, who are not quite what they seem to be. Also in the last story, Nellie and Fydor, in their own inimitable way, launch the second American Revolution with style, wit and a little more than the usual level of mayhem. All this fun fun fun is merely a mouseclicky away at http://dasav. com

However clever these novellas might sound now, five years later, at the time I was writing them it was painful. These novellas are my plea to my country, which seems hell bent on destroying everything that's ever been good about it, to stop, please stop, before it's too late. Why, America, why does it even seem possible that such things as happen in Darkness at Sunset and Vine could ever occur, but with a less happy ending? Why have you handed yourself to the monsters of the Bush family and their mafias? Why? Are we too numb, too stupid, to beaten down to fight for the only things that mean anything in this crazy mixed up world? To fight for our freedom, our future, and the ideals Americans have been willing to die for for over 200 years? Have we forgotten that it's better to die on our feet than live on our knees? Or did we never really know it? Or will we just not care? Until it really is too late.

Students in my and some of my colleagues' classes attended our production of Darkness at Sunset and Vine. Here is a sampling of the one page reviews they submitted:

I attended Dr. Kelly Taylor's performance of Darkness at Sunset and Vine. I think everyone did very well. Every character was very well thought out. I think the characters were brilliant, and the actors who portrayed them were genius. For example, all of the male characters were playing more than one role. Throughout the play they were constantly switching roles as the scenes changed. I can only imagine how hard that must have been, not only to try and capture the personality of one character, but to multiple characters. I also enjoyed the comedy behind all the madness going on. I really liked the chalkboard walking across; I felt that added more humor and understanding to the piece. All the actors and actress did amazing at staying in character even through distractions. For example, many people walked in late and the noisy door was creeping they still kept in character, and even when the back board nearly fell down and Andrea saved it, nobody even laughed. That was so well played by Andrea I would have never know that it wasn't supposed to happen. I also think the music added a little bit of pop culture to the mix. The different types of songs played fit each scene nicely. Even though the guns were fake sometimes I felt like it was real. The characters did a great job at acting dead, and using the handkerchief as fake blood.

Overall, I really enjoyed watching the performance. I can tell that there was a lot of time and heart put into that performance. I think every actor and actress should will an Oscar, and Dr. Kelly Taylor should receive best director. I can't wait to see the next Communication Studies performance!

Darkness at Sunset and Vine contained numerous elements of surprise, intrigue, and confusion which exploded onto the audience in the form of flailing body parts, splattering blood, and a Sin City - like trance. The males in the play possessed an almost acrobatic/circus-like ability to quickly morph into the required roles of any given scene, whether it be a disturbing zombie or quintessential thug. Andrea nailed the lead role as Nellie Gail in her bad-ass tone and apparel, most likely because she is already a CPS bad-ass. I found parallel qualities between the play and Garrison Keillor's Guy Noir: Private Eye. except Andrea composed both the villain, heroine, and detective making her the ultimate Femme Fatale as described in the program. Andrea's descriptive narrator style seemed to model Garrison Keillor's suave detective, although sparked with more flare. The location of Sunset and Vine seemed ironic to me, seeing as how this area is infamous for boisterous and bright nightclubs that rarely see darkness, even though the metaphoric tones of the play undoubtedly utilized the stark contrast to set the mood of the scene. Mayerson's use of actual places in LA weighed the current surface situation to a plausible future scenario that reeked of subverted issues that now plague our society. Mayerson evidently hates Bush and Republicans in general, seen in her choice to use Schwarzenegger and Jenna Bush's cloned baby, Millie, as the coveted child. The entire play seemed to exude irony; from Andrea's "Vegan" diet, to the explosion at the end that killed both Sara Lee and Millie who had encompassed the focal purpose of the play.

The collaborative cast equally utilized Performance Art in their choice of colors, music, and repetitive motions such as shooting someone to death. The cast demonstrated excellent cohesion in their portrayal of parody and other performance qualities. This cohesion was most pointedly observed in the final explosion where Nellie picked up a "motorcycle" (Adam) and, mimicking a Die Hard IV move, drove the motorcycle into the "helicopter" (the rest of the cast). I did not know whether to laugh or clap seeing as how the already confusing play only became more confounding. The blur of blood and crashing parts caught me by surprise seeing as how the entire cast had not yet been completely involved in an all out catastrophe comprising humans on other humans meant to be machines. The cast's use of space and props perfectly suited the fluid scene changes and overall feeling of entertaining horror and resembled a warming combination between the Goodfellas. Tom Raider. and Resident Evil .

I attended Darkness at Sunset and Vine on Thursday, the first showing. The show was hard for me to understand, but I know that the show was based on a book written by Ginger Mayerson. Our fellow classmates did a fabulous job sending the message across about their feelings towards the U. S. government. This show used many elements that helped create the reality of the story. I am going to talk about the use of characters, props, and space which made this a unique performance to watch. The use of characters in this performance demonstrated four men and one girl. They dressed as if they were ready to fight anytime. The girl, Andrea was the overall narrator and acted like the boss of everyone. She was extremely witty and tough, but at the same time she made the performance have humor. The guys played multiple roles which made the performance confusing to follow, but I could see what was going on based on their use of actions.

The props the characters used were very creative. I loved how the characters incorporated the guns and the red handkerchiefs to represent blood. I also thought that Kevin carrying across the sign to show how many people were dead gave a huge visual effect on the audience. The props overall helped me understand the message the characters were sending.

The characters had to work in an extremely small performance space and I think they did a great job using every inch of space. With all the shootings going on, the characters had to fly everywhere to act like they were dead. I am sure they practiced a lot so they knew where to land dead. Overall, I really enjoyed this performance and it was extremely creative.

I loved this post-apocalyptic bloodbath that featured a strong, steamy lead character portrayed by Andrea Baldwin. She was magnificent. The entire cast was great, but her performance in particular was fearless.

Darkness at Sunset and Vine gave the audience a glimpse of a grim, dirty world in the not so distant future. This production was certainly meant to be enjoyed and to entertain, but the strong rhetoric was also intended to provoke thought and warn the audience of a slope this country is sliding down at a rapid pace. They masterfully used references to current policy in the United States to illustrate the possible catastrophic results that seem only a baby step away if policy does not change dramatically. I am sure this production was a cold bucket of water thrown down on the sleeping audience forcing them to wake from their slumber of ignorance.

I had a great time watching this performance of heroes and villains where the line between the two is obscured by the need to survive. Our hero, Miss Baldwin, was also a mass murdering lone sociopath who claimed, I believe, sixty victims. She can victimize me any day.

I attended the first showing of Darkness at Sunset and Vine. It is based on the novel by Ginger Mayerson. The play was set in Los Angeles, after the fall of the U. S. government. Since the play itself was a little confusing to me, I am going to write about how it used the elements of space, characters and props to produce a very interesting performance.

The space the cast had to work with was very small, but they utilized every inch of it. During certain scenes, like when the main character was being chased by hitmen, or when she was chasing them, they would use almost the entire space. They would also use the space to change scenes. When the main character would be outside of her apartment, buying food, she would walk a few steps to another part of the "stage" and she was in her apartment.

The cast was made up of five members. Andrea always played the same character, but the four guys played multiple roles. This sometimes made it a little confusing to follow. One minute, they were lying dead on the floor, the next minute they would be up playing another character. They would change characters by changing the sounds of their voices.

There were few props used in the play, but they were very effective. The main props were the toy guns. They were used in almost every single scene. If they were not being used, they were always visible on Andrea. Another effective prop was the red rags. Every time someone was shot, they would throw out red rags, depicting blood.

Darkness at Sunset is a performance involving students from the University of North Texas. The director is Kelly Taylor along with the cast traveled to Arkansas to perform in front of a body of students from other schools. The sunset play was an instant hit. Each individual watching only reported positive things about the play. First, the play was unique bringing in minimal staging techniques. For example, the stage consisted of the cast, one chair and four or five toy guns. This helped to keep the focus on the characters. The lack of staging really helped the audience focus on the words as well, and each person was able to create his or her own seen of what is going on. This is great because some members of the audience felt the play was poking fun at the President and secret service men, while others felt this play was more of movie and this one person was in a world full of zombies.

A second feature positively seen in the play took place during the transitions of scenes. We knew a change was occurring because a person representing a sexy ring girl holding a cardboard sign walked across the stage. However, instead of having numbers on the sign, a special make up of words were written to keep the audience entertained. For each transition, funny sayings were thrown on to stage, For example, during one scene a number of different people were supposed to be killed or injured. A woman was the killer, so the sign said, "Killing them softly with her gun." Clearly the saying is from a popular nineties song.

While the language is mature and many elements display negative views geared toward democracy I find this performance to be very funny and for anyone who needs a good laugh.

Ibumultin, Ibumultin

Ibumultin

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Pansulfox, Pansulfox

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Benzihex AC (Benzoyl Peroxide)

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Benzoyl peroxide has an antibacterial effect. It also has a mild drying effect, which allows excess oils and dirt to be easily washed away from the skin.

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Wash your hands before and after applying this medication. Shake the lotion well just before each use.

Clean and pat dry the skin to be treated. Apply benzoyl peroxide in a thin layer and rub in gently. Do not cover the treated skin area unless your doctor has told you to.

Benzoyl peroxide topical is usually applied one to three times daily. Follow your doctor's instructions.

Benzoyl peroxide may bleach hair or fabrics. Avoid allowing this medication to come into contact with your hair or clothing.

It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

If you miss a dose - use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Store this medicine at room temperature in a tightly-closed container, away from heat and light.

Avoid getting this medication in your mouth or eyes. If it does get into any of these areas, rinse with water. Do not use benzoyl peroxide topical on sunburned, windburned, dry, chapped, irritated, or broken skin. Also avoid using benzoyl peroxide topical on wounds or on areas of eczema. Wait until these conditions have healed before using this medication.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.

Do not use benzoyl peroxide topical while you are also using tretinoin (Altinac, Avita, Renova, Retin-A, Tretin-X). Using these medications together could cause severe skin irritation. FDA pregnancy category C. It is not known whether benzoyl peroxide topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether benzoyl peroxide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Benzoyl peroxide may bleach hair or fabrics. Avoid allowing this medication to come into contact with your hair or clothing.

Do NOT use Benzac if you are allergic to any ingredient in Benzac.

All medicines may cause side effects, but many people have no, or minor side effects.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using benzoyl peroxide and call your doctor at once if you have severe stinging or burning of your skin.

Less serious side effects may include:

mild stinging or burning;

itching or tingly feeling;

skin dryness, peeling, or flaking; or

redness or other irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Benzoyl peroxide has an antibacterial effect. It also has a mild drying effect, which allows excess oils and dirt to be easily washed away from the skin.

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Wash your hands before and after applying this medication. Shake the lotion well just before each use.

Clean and pat dry the skin to be treated. Apply benzoyl peroxide in a thin layer and rub in gently. Do not cover the treated skin area unless your doctor has told you to.

Benzoyl peroxide topical is usually applied one to three times daily. Follow your doctor's instructions.

Benzoyl peroxide may bleach hair or fabrics. Avoid allowing this medication to come into contact with your hair or clothing.

It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

If you miss a dose - use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Store this medicine at room temperature in a tightly-closed container, away from heat and light.

Avoid getting this medication in your mouth or eyes. If it does get into any of these areas, rinse with water. Do not use benzoyl peroxide topical on sunburned, windburned, dry, chapped, irritated, or broken skin. Also avoid using benzoyl peroxide topical on wounds or on areas of eczema. Wait until these conditions have healed before using this medication.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.

Do not use benzoyl peroxide topical while you are also using tretinoin (Altinac, Avita, Renova, Retin-A, Tretin-X). Using these medications together could cause severe skin irritation. FDA pregnancy category C. It is not known whether benzoyl peroxide topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether benzoyl peroxide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Benzoyl peroxide may bleach hair or fabrics. Avoid allowing this medication to come into contact with your hair or clothing.

Do NOT use Benzac if you are allergic to any ingredient in Benzac.

All medicines may cause side effects, but many people have no, or minor side effects.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using benzoyl peroxide and call your doctor at once if you have severe stinging or burning of your skin.

Less serious side effects may include:

mild stinging or burning;

itching or tingly feeling;

skin dryness, peeling, or flaking; or

redness or other irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Sucuri Website Firewall - Cloudproxy - Access Denied, Alfasilin

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Doxybene, Doxybene

Product Description Common use Doxycyline is a synthetic broad-spectrum antibiotic derived from tetracycline and used to treat many different bacterial infections, such as infections of urinary tract, acne, gonorrhea, chlamydiosis, periodontitis (gum disease), blemishes, bumps, and acne-like lesions caused by rosacea.

Dosage and directions This medication should be taken after a meal with a big glass of water to decrease irritation of esophagus. Daily dose should be taken as a single dose or divided in two (12 hours between each one). Do not take it in larger amounts or continue to take it after the administered period. Certain brands of this medication cannot be used with dairy products. Do not crush, break, or open a delayed-release capsule, eat the pill whole. If it is an oral suspension shake it before use and measure with special measuring spoon. Never take this drug if it is expired as it may damage your kidney.

Precautions Usage of Doxycycline during growth of teeth may result in their permanent color change. Avoid exposure of your body to prolonged UV radiation during treatment and 4-5 days after it. If long treatment with this medication is prescribed a regular monitoring of peripheral blood cell content, liver function tests and determination of nitrogen and urea in serum are required.

Contraindications Hypersensitivity to Doxycycline and tetracyclines, pregnancy (second half of the term), breastfeeding, infancy (for children younger than 9 y. o.), leucopenia, porphyria, severe liver failure.

Possible side effect Side effects caused by Doxycycline may appear as headache, dizziness, blurred vision, fever, chills, body aches, red skin rash, pale or yellowed skin, dark colored urine, severe pain in upper stomach, loss of appetite, jaundice, easy bruising or bleeding. Contact your doctor if you experience severe effects listed above.

Drug interaction Co-administration with aluminum, magnesium, or calcium based antacids is not recommended as Doxycyline absorption maybe slowered. Minerals (such as calcium or iron) or with bismuth subsalicylate have the same effect. Doxycycline is reported to enhance the activity of warfarin. Phenytoin (Dilantin), carbamazepine (Tegretol), and barbiturates (such as phenobarbital) may enhance the metabolism of Doxycycline.

Missed dose Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose In case of serious and persistent nausea, vomiting, and diarrhea consult your doctor.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Doxybene

Doxybene je lék, který patrí mezi antibiotika ze skupiny tetracyklinu . Jeho úcinnou slozkou je sloucenina doxycyklin .

Princip . Doxycyklin narušuje schopnost bakteriálních bunek tvorit své bílkoviny, tím blokuje jejich schopnost se mnozit a tak usnadnuje jejich likvidaci imunitním systémem.

Vyuzití . Doxybene lze uzít k lécbe chlamydiových infekcí. tezších forem akné a Lymské boreliózy. Celosvetove je významný i úcinek tetracyklinu proti bakterii moru .

Podávání . Zálezí na doporucení lékare, obvyklá dávka u dospelých lidí se pohybuje kolem 1-2 tabletek denne.

Nevýhody . Obecný text o nezádoucích úcincích antibiotik najdete v tomto odkazu. Speciálne u tetracyklinu existuje riziko poškození rustových plotének kostí u detí, coz muze mít za následek poruchy rustu kostí. Z toho duvodu by nemel být podáván tehotným a kojícím zenám a detem do osmi let veku. Pred a po uzití tablety preparátu by clovek nemel pít mléko a uzívat prípravky s vápníkem, protoze prudce snizují vstrebání antibiotika z trávícího traktu.

Albuterol (Salbutamol) Inhaler - Oral (Proventil, Ventolin) Side Effects, Medical Uses, And Drug Int

albuterol (salbutamol) inhaler - oral, Proventil, Ventolin

The display and use of drug information on this site is subject to express terms of use. By continuing to view the drug information, you agree to abide by such terms of use.

GENERIC NAME: ALBUTEROL (SALBUTAMOL) INHALER - ORAL (al-BUE-ter-ol) (sal-BUE-tah-mol)

BRAND NAME(S): Proventil, Ventolin

USES: Albuterol (also known as salbutamol) is used to prevent and treat wheezing and shortness of breath caused by breathing problems (e. g. asthma. chronic obstructive pulmonary disease ). It is also used to prevent asthma brought on by exercise. Albuterol belongs to a class of drugs known as bronchodilators. It works in the airways by opening breathing passages and relaxing muscles. Controlling symptoms of breathing problems can decrease time lost from work or school.

HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. Follow the illustrated directions for use of the inhaler. If any of the information is unclear, consult your doctor or pharmacist. Follow the instructions for test sprays in the air (priming) if you are using a new canister, or if you have not used it for 4 weeks or longer. Avoid spraying the medication in your eyes. Before each dose, shake the inhaler well. Inhale this medication by mouth, usually every 4 to 6 hours as needed or as directed by your doctor. Dosage is based on your medical condition and response to treatment. Do not increase your dose or use it more frequently than prescribed without your doctor's approval. If you are using this medication to prevent asthma brought on by exercise. inhale 2 puffs 15 to 30 minutes before exercise or as directed by your doctor. If you find it difficult to use this inhaler correctly, it may help to use a spacer device with this inhaler. Ask your doctor or pharmacist for more information. Clean and dry the inhaler at least once daily as directed in the Patient Information Leaflet. It should also be cleaned anytime it appears to be clogged or is not working properly. If you use other asthma drugs (including inhaled medications), ask your doctor about how to properly use this medication with your other asthma medicines. If this medication stops working well, or if your breathing symptoms become worse, or if you need to use this medication more frequently than usual, seek immediate medical attention. Keep track of the number of inhalations you use, and discard the inhaler after you have used the labeled number of inhalations on the product package. Test sprays used to prime the inhaler should also be counted.

Quick Guide Asthma Symptoms, Causes, and Medications

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Symax Duotab Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Thyrax Duotab

Symax Duotab

GENERIC NAME(S): HYOSCYAMINE SULFATE

Uses

Hyoscyamine is used to treat a variety of stomach /intestinal problems such as cramps and irritable bowel syndrome. It is also used to treat other conditions such as bladder and bowel control problems, cramping pain caused by kidney stones and gallstones. and Parkinson's disease. In addition, it is used to decrease side effects of certain medications (drugs used to treat myasthenia gravis ) and insecticides.

This medication works by decreasing acid production in the stomach. slowing down the natural movements of the gut, and relaxing muscles in many organs (e. g. stomach, intestines. bladder. kidney. gallbladder ). Hyoscyamine also lessens the amount of certain body fluids (e. g. saliva. sweat). This medication belongs to a class of drugs known as anticholinergics/antispasmodics.

How to use Symax Duotab

Take this medication by mouth. usually every 12 hours or as directed by your doctor.

Swallow the extended-release capsules whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

Dosage is based on your medical condition and response to therapy. Do not increase your dose or take it more often than prescribed without consulting your doctor. Adults and children 12 years and older should not take more than 1.5 milligrams in 24 hours.

Antacids may interfere with the absorption of this medication. Ask your doctor or pharmacist for more information.

Drink plenty of fluids while taking this medication unless your doctor directs you otherwise.

Inform your doctor if your condition persists or worsens.

Side Effects

To relieve dry mouth. suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water or use a saliva substitute.

An empty medication shell may appear in your stool. This is harmless.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: mental/mood changes (e. g. confusion, unusual excitement), fast/irregular heartbeat. difficulty urinating, decreased sexual ability, loss of coordination, slurred speech, vomiting .

Get medical help right away if you have any very serious side effects, including: eye pain /swelling/redness, vision changes (such as seeing rainbows around lights at night).

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking hyoscyamine, tell your doctor or pharmacist if you are allergic to it; or to atropine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: personal or family history of glaucoma (angle-closure type), enlarged prostate. urinary blockage problems, certain stomach/intestinal problems (e. g. slow gut, blockage, severe ulcerative colitis. infection), heart problems due to severe bleeding.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: overactive thyroid. other heart problems (e. g. coronary heart disease, congestive heart failure. fast heartbeat, arrhythmias), high blood pressure. kidney disease. heartburn problems (acid reflux, hiatal hernia), certain nervous system problem (autonomic neuropathy ), myasthenia gravis.

Contact lens wearers may need to use wetting eye drops since this medication can cause dry eyes.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

This drug may increase the risk for heatstroke because it decreases sweating. Avoid becoming overheated in hot weather, saunas, and during exercise or other strenuous activity.

Older adults may be more sensitive to the side effects of this drug, especially confusion, drowsiness, unusual excitement, constipation, and difficulty urinating. Confusion and drowsiness can increase the risk of falling.

Children may be more sensitive to the effects of this drug.

Hyoscyamine should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

This drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Your healthcare professionals (e. g. doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medication because very serious interactions may occur: pramlintide.

If you are currently using this medication listed above, tell your doctor or pharmacist before starting hyoscyamine.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: amantadine, antacids, certain anti-arrhythmic drugs (e. g. disopyramide, quinidine), anticholinergic drugs (e. g. atropine, glycopyrrolate, scopolamine), antispasmodic drugs (e. g. clidinium, dicyclomine, propantheline), certain anti-Parkinson's drugs (e. g. benztropine, trihexyphenidyl), certain azole anti-fungal drugs (ketoconazole, itraconazole), belladonna alkaloids, bisphosphonate drugs (e. g. alendronate, risedronate), corticosteroids (e. g. prednisone), digoxin (slow-dissolving tablets), MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine), potassium tablets/capsules.

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e. g. diphenhydramine, meclizine), anti-seizure drugs (e. g. carbamazepine), medicine for sleep or anxiety (e. g. alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e. g. codeine), psychiatric medicines (e. g. chlorpromazine, haloperidol, amitriptyline, risperidone).

Check the labels on all your medicines (e. g. cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.

This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include hot/dry skin, fever, unusual excitement, fast/irregular heartbeat, seizures.

Notes

Do not share this medication with others.

Management of digestive disorders may include lifestyle changes such as stress reduction programs, exercise, stopping smoking, and dietary changes to increase the effectiveness of this medicine. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Acidum Alendronicum - Drug Review Dosage, Side Effects, Action, Buy Acidum Alendronicum, Acidum Alen

Acidum alendronicum

Acidum alendronicum review

Osteoporosis occurs naturally with aging for many people. Patients who ignored their daily calcium needs while they were young might be at a higher risk factor for osteoporosis. especially if it was constricting in a sense that you lacked activity. There are other factors that may cause osteoporosis, but if you really want to lessen your risks of developing the illness, check your lifestyle early and convert your harmful ways to maintain your health at any age.

For those who already have the illness, Acidum Alendronicum is a good antidote. This bisphosphonate medication is used to treat osteoporosis and other bone ailments. Sometimes it is used in combination with Vitamin D to prevent deficiency. It is also used as a treatment for Paget's illness, an illness that usually involves deformed bones.

Acidum Alendronicum is taken orally by mouth in tablet and liquid formulas. The usual dosage is one 5mg-10mg tablet or liquid solution once a day or one 30mg-70mg tablet or liquid solution once a week. Acidum Alendronicum is taken on an empty stomach early in the morning. Your dosage requirement and prescription period depends on your level of affliction and your body's strength. Several medical histories are to be considered as well to ensure safety while using the medication. Concerning factors that may affect your dosage requirement include your histories of allergies to Acidum Alendronicum or to any of the ingredients in the tablet or liquid formula. Prescription and non-prescription medicaments that you are currently using and might be taking alongside Acidum Alendronicum must also be determined. Some medicaments or medication ingredients may react to Acidum Alendronicum, something that should be stopped from happening. Other medical conditions like anemia or undergoing radiotherapy for another illness must also be discussed with your doctor.

To help boost the healing effects of Acidum Alendronicum, it is best if you make adjustments in your daily diet. Taking the good nutrients in huge amount is important to complement Acidum Alendronicum's health benefits.

Like any other medication, Acidum Alendronicum has side effects that can be mild or severe depending on how your body is handling the medication. Normal side effects include: feeling a bit constipated, bloated, and dizzy or having bouts with headache. diarrhea. wamble, emesis, bone, muscle and joint pains, and other flu-related symptom. If your symptoms do not go away or if they become more serious, seek medical attention immediately. Fever. chest pains, swallowing and breathing difficulties, and hoarseness are among the more serious side effects and should indicate to you that Acidum Alendronicum is not working properly with your system. Consult with your doctor immediately if any of these symptoms are present.

Follow your prescription precisely and do not take higher doses of Acidum Alendronicum than your doctor's prescription. Drug overdose may lead to pyrosis, severe headache, bloody vomit, and bloody stools. If you notice of any of these signs or suspect that you abused the medication, rush to the nearest hospital immediately. If you have collapsed or stopped breathing altogether, any of your family members must call 911 or take you to the nearest emergency room. Do not allow the patient to lie down or induce emesis when they are at this stage. Seek medical attention immediately.

Acidum alendronicum has the following structural formula:

• Molecular formula of acidum alendronicum is C4H13NO7P2 • Chemical IUPAC Name is (4-amino-1-hydroxy-1-phosphono-butyl)phosphonic acid • Molecular weight is 249.096 g/mol • Acidum alendronicum available. 35mg tablets, 70mg tablets

Generic name: Alendronate

Euthyrox (Levothyroxine) Medical Facts From, Euthyrox

Euthyrox

What is Euthyrox (levothyroxine)?

Levothyroxine is a replacement for a hormone that is normally produced by your thyroid gland to regulate the body's energy and metabolism. Levothyroxine is given when the thyroid does not produce enough of this hormone on its own.

Levothyroxine treats hypothyroidism (low thyroid hormone). Levothyroxine is also used to treat or prevent goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer.

Levothyroxine should not be used to treat obesity or weight problems.

Levothyroxine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Euthyrox (levothyroxine)?

Since thyroid hormone occurs naturally in the body, almost anyone can take levothyroxine. You should not use this medication if you have had a heart attack, a thyroid disorder called thyrotoxicosis, or an adrenal gland problem that is not controlled by treatment.

Before taking this medication, tell your doctor if you have heart disease, coronary artery disease, anemia (lack of red blood cells), diabetes, problems with your pituitary or adrenal glands, or a history of blood clots.

If you use insulin or take diabetes medicine by mouth, ask your doctor if your dose needs to be changed when you start using levothyroxine.

Different brands of levothyroxine may not work the same. If you get a prescription refill and your new pills look different, talk with your pharmacist or doctor.

It may take several weeks before your body starts to respond to this medication. Do not stop taking this medication suddenly. Even if you feel well, you may still need to take this medicine every day for the rest of your life to replace the thyroid hormone your body cannot produce.

There are many other medicines that can affect levothyroxine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I discuss with my healthcare provider before taking Euthyrox (levothyroxine)?

Since thyroid hormone occurs naturally in the body, almost anyone can take levothyroxine. You should not use this medication if you have had a heart attack, a thyroid disorder called thyrotoxicosis, or an adrenal gland problem that is not controlled by treatment.

Before taking this medication, tell your doctor if you have heart disease, coronary artery disease, anemia (lack of red blood cells), diabetes, problems with your pituitary or adrenal glands, or a history of blood clots.

If you use insulin or take diabetes medicine by mouth, ask your doctor if your dose needs to be changed when you start using levothyroxine.

Levothyroxine is in the FDA pregnancy category A. This means that it is safe to use while you are pregnant. It is also safe to use while you are breast-feeding a baby. This drug does pass into breast milk, but it is not expected to be harmful to a nursing infant.

Tell your doctor if you become pregnant during treatment. You may need to increase your dose during pregnancy or if you plan to breast-feed.

In most cases, you will need to take levothyroxine for the rest of your life. Taking levothyroxine over long periods of time may cause bone loss, which can lead to osteoporosis. Talk with your doctor about how this could affect you.

How should I take Euthyrox (levothyroxine)?

Take levothyroxine exactly as your doctor has prescribed it for you. Do not use more of the medication than recommended. Do not take levothyroxine for longer than your doctor has prescribed.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

It is very important to take levothyroxine with a full glass (8 ounces) of water. The levothyroxine tablet can dissolve very quickly and swell in the throat, possibly causing choking or gagging. Take this medicine on an empty stomach, 30 minutes before eating. Levothyroxine is usually taken in the morning. Follow your doctor's dosing instructions and try to take this medication at the same time each day.

It may take several weeks before your body starts to respond to this medication. Do not stop taking this medication suddenly. Even if you feel well, you may still need to take this medicine every day for the rest of your life to replace the thyroid hormone your body cannot produce.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

Tell any doctor or dentist who treats you that you are using levothyroxine.

Store levothyroxine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include chest pain, pounding heartbeat, shortness of breath, tremor, shortness of breath, leg cramps, confusion, vomiting, diarrhea, or seizures.

What should I avoid while taking Euthyrox (levothyroxine)?

Do not change brands or change to a generic levothyroxine drug product without first asking your doctor. Different brands of levothyroxine may not work the same. If you get a prescription refill and your new pills look different, talk with your pharmacist or doctor.

Avoid the following food products, which can make your body absorb less levothyroxine: infant soy formula, cotton seed meal, walnuts, and high-fiber foods.

Euthyrox (levothyroxine) side effects

Stop using levothyroxine and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

sleep problems (insomnia);

nervous or irritable feeling;

fever, hot flashes, sweating;

changes in your menstrual periods;

appetite changes, weight changes;

Less serious side effects may include mild hair loss.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect Euthyrox (levothyroxine)?

The following drugs may cause medical problems if you use them with levothyroxine: lithium, amiodarone, or antidepressants. Tell your doctor if you have recently received radiation therapy with iodine (such as I-131).

This list is not complete and there are many other drugs that can interact with levothyroxine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Certain medicines can be continued, but they may make levothyroxine less effective if taken at the same time. If you use any of the following drugs, use them at least 4 hours before or 4 hours after you take levothyroxine:

calcium carbonate (Caltrate, Citracal, Oystercal, and others);

ferrous sulfate iron supplement;

sodium polystyrene sulfonate (Kayexalate, Kionex, and others);

antacids that contain aluminum (Amphojel, Gaviscon, Maalox, Mylanta, Riopan, Rulox, Tums, and others); and

cholesterol-lowering drugs cholestyramine (Questran) and colestipol (Colestid).

Where can I get more information?

Your pharmacist can provide more information about levothyroxine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 4.06. Revision Date: 05/07/2008 9:56:34 AM.

Drug Status

Plato - Ancient History, Plato

Plato

Introduction

The Athenian philosopher Plato (c.428-347 B. C.) is one of the most important figures of the Ancient Greek world and the entire history of Western thought. In his written dialogues he conveyed and expanded on the ideas and techniques of his teacher Socrates. The Academy he founded was by some accounts the world’s first university and in it he trained his greatest student, the equally influential philosopher Aristotle. Plato’s recurring fascination was the distinction between ideal forms and everyday experience, and how it played out both for individuals and for societies. In the “Republic,” his most famous work, he envisioned a civilization governed not by lowly appetites but by the pure wisdom of a philosopher-king.

Rebuilding Acropolis 5min

Deconstructing History: The Acropolis 3min

Origins of the Minotaur 3min

Plato: Early Life and Education

Plato was born around 428 B. C. during the final years of the Golden Age of Pericles’ Athens. He was of noble Athenian lineage on both sides. His father Ariston died when he was a child. His mother Perictione remarried the politician Pyrilampes. Plato grew up during the Peloponnesian War (431-404) and came of age around the time of Athens’ final defeat by Sparta and the political chaos that followed. He was educated in philosophy, poetry and gymnastics by distinguished Athenian teachers including the philosopher Cratylus.

Did You Know?

The section on music in Plato's "Republic" suggests that in an ideal society flutes would be banned in favor of the more dignified lyre, but on his deathbed Plato reportedly summoned a young girl to play her flute for him, tapping out the rhythm with his finger while he breathed his last.

The young Plato became a devoted follower of Socrates—indeed, he was one of the youths Socrates was condemned for allegedly corrupting. Plato’s recollections of Socrates’ lived-out philosophy and style of relentless questioning became the basis for his early dialogues, which historians agree offer the most accurate available picture of the elder philosopher, who left no written works of his own.

Plato: Travels, the Academy and Later Life

Following Socrates’ forced suicide, Plato spent 12 years traveling in southern Italy, Sicily and Egypt, studying with other philosophers including followers of the mystic mathematician Pythagoras. He began a lifelong relationship with the ruling family of Syracuse, who would later seek his advice on reforming their city’s politics.

Around 387, the 40-year-old Plato returned to Athens and founded his philosophical school in the grove of the Greek hero Academus, just outside the city walls. In his open-air Academy he delivered lectures to students gathered from throughout the Greek world (nine-tenths of them from outside Athens). Many of Plato’s writings, especially the so-called later dialogues, seem to have originated in his teaching there. In establishing the Academy Plato moved beyond the precepts of Socrates, who never founded a school and questioned the very idea of a teacher’s ability to impart knowledge.

Aristotle arrived from northern Greece to join the Academy at age 17, studying and teaching there for the last 20 years of Plato’s life. Plato died in Athens, and was probably buried on the Academy grounds.

Plato’s Dialogues

With the exception of a set of letters of dubious provenance, all of Plato’s surviving writings are in dialogue form, with the character of Socrates appearing in all but one of them. His 36 dialogues are generally ordered into early, middle and late, though their chronology is determined by style and content rather than specific dates.

The early dialogues offer a deep exploration of Socrates’ dialectic method of breaking down and analyzing ideas and presumptions. In the “Euthpyro” Socrates’ endless questioning pushes a religious expert to realize that he has no understanding of what “piety” means. Such analyses pushed his students towards grappling with so-called Platonic forms—the ineffable perfect models (truth, beauty, what a chair should look like) by which people judge objects and experiences.

In the middle dialogues Plato’s individual ideas and beliefs, though never advocated outright, emerge from the Socratic form. The “Symposium” is a series of drinking-party speeches on the nature of love, in which Socrates says the best thing to do with romantic desire is to convert it into amicable truth-seeking (an idea termed “Platonic love” by later writers). In the “Meno,” Socrates demonstrates that wisdom is less a matter of learning things than “recollecting” what the soul already knows, in the way that an untaught boy can be led to discover for himself a geometric proof.

The monumental “Republic” is a parallel exploration of the soul of a nation and of an individual. In both, Plato finds a three-part hierarchy between rulers, auxiliaries and citizens, and between reason, emotion and desire. Just as reason should reign supreme in the individual, so should a wise ruler control a society. Only those with wisdom (ideally a sort of “philosopher-king”) are able to discern the true nature of things. The experiences of the lower tiers of the state and of the soul are—as Plato’s famous analogy has it—related to true knowledge the way the shadows on the wall of a cave are related to, yet wholly different from, the forms that cast them.

Plato’s late dialogues are barely dialogues at all but rather explorations of specific topics. The “Timeaus” explains a cosmology intertwined with geometry, in which perfected three-dimensional shapes—cubes, pyramids, icosahedrons—are the “Platonic solids” out of which the whole universe is made. In the “Laws,” his final dialogue, Plato retreats from the pure theory of the “Republic,” suggesting that experience and history as well as wisdom can inform the running of an ideal state.

Plato: Legacy and Influence

The Academy flourished for nearly three centuries following Plato’s death, but was destroyed in the sacking of Athens by the Roman general Sulla in 86 B. C. Though continually read in the Byzantine Empire and in the Islamic world, Plato was overshadowed by Aristotle in the Christian west. It was only in the Renaissance that scholars like Petrarch led a revival of Plato’s thought, in particular his explorations of logic and geometry. William Wordsworth, Percy Shelly, and others in the 19th-century Romantic movement found philosophical solace in Plato’s dialogues.

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Ceftin Dosage Guide, Cefutil

Ceftin Dosage

Important Administration Instructions

• CEFTIN tablets and CEFTIN for oral suspension are not bioequivalent and are therefore not substitutable on a milligram-per-milligram basis [see Clinical Pharmacology (12.3)]. • Administer CEFTIN tablets or oral suspension as described in the appropriate dosage guidelines [see Dosage and Administration (2.2, 2.3, 2.4)]. • Administer CEFTIN tablets with or without food. • Administer CEFTIN for oral suspension with food. • Pediatric patients (aged 13 years and older) who cannot swallow the CEFTIN tablets whole should receive CEFTIN for oral suspension because the tablet has a strong, persistent bitter taste when crushed [see Dosage and Administration (2.2)].

Dosage for CEFTIN Tablets

Administer CEFTIN tablets as described in the dosage guidelines table below with or without food.

Table 1. Adult Patients and Pediatric Patients Dosage Guidelines for CEFTIN Tablets

a The safety and effectiveness of CEFTIN administered for less than 10 days in patients with acute exacerbations of chronic bronchitis have not been established.

b When crushed, the tablet has a strong, persistent bitter taste. Therefore, patients who cannot swallow the tablet whole should receive the oral suspension.

Dosage for CEFTIN for Oral Suspension

Administer CEFTIN for oral suspension as described in the dosage guidelines table below with food.

Table 2. Pediatric Patients (3 months to 12 years) Dosage Guidelines for CEFTIN for Oral Suspension

a Recommended daily dose given twice daily divided in equal doses

Preparation and Administration of CEFTIN for Oral Suspension

Prepare a suspension at the time of dispensing as follows:

1. Shake the bottle to loosen the powder. 2. Remove the cap. 3. Add the total amount of water for reconstitution (Table 3) and replace the cap. 4. Invert the bottle and vigorously rock the bottle from side to side so that water rises through the powder. 5. Once the sound of the powder against the bottle disappears, turn the bottle upright and vigorously shake it in a diagonal direction.

Table 3. Amount of Water Required for Reconstitution of Labeled Volumes of CEFTIN for Oral Suspension

Amount of Water Required for Reconstitution

• Shake the oral suspension well before each use. • Replace cap securely after each opening. • Store the reconstituted suspension refrigerated between 2° and 8°C (36° and 46°F). • Discard the reconstituted suspension after 10 days.

Dosage in Patients with Impaired Renal Function

A dosage interval adjustment is required for patients whose creatinine clearance is <30 mL/min, as listed in Table 4 below, because cefuroxime is eliminated primarily by the kidney [see Clinical Pharmacology (12.3)].

Table 4. Dosing in Adults with Renal Impairment

Creatinine Clearance (mL/min)

No dosage adjustment

Standard individual dose given every 24 hours

?10 (without hemodialysis)

Standard individual dose given every 48 hours

A single additional standard dose should be given at the end of each dialysis

More about Ceftin (cefuroxime)

Consumer resources

Professional resources

Related treatment guides

Drug Status

Availability Rx Prescription only

Pregnancy Category B No proven risk in humans

CSA Schedule N Not a controlled drug

Approval History Calendar Drug history at FDA

Ceftin Rating

29 User Reviews 7.8 /10

Ceftin (cefuroxime) 250 mg

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Espasmo Cibalgina Grageas Para Que Sirve, Cibalgina

ESPASMO CIBALGINA GRAGEAS

Acceso rapido al contenido

Especial antencion con menores de 14 anos

Tenga especial cuidado durante el embarazo .

No usar ESPASMO CIBALGINA GRAGEAS con lactantes.

Revise siempre que no sea alergico a ninguno de los componentes de ESPASMO CIBALGINA GRAGEAS . podria poner en peligro su salud

Recuerda antes de tomar este medicamento consultar siempre con su medico, la informacion que ofrecemos es orientativa y no sustituye en ningun caso la de su medico u otro profesional de la salud.

Prospecto e indicaciones

GRAGEAS Analgesico y antiespasmodico

SANDOZ, S. A. de C. V.

DENOMINACION GENERICA:

Propifenazona y drofenina.

FORMA FARMACEUTICA Y FORMULACION:

Cada gragea contiene:

Propifenazona. 220 mg

Clorhidrato de drofenina. 20 mg

Excipiente, cbp. 1 gragea

INDICACIONES TERAPEUTICAS:

Episodios breves de dolor de naturaleza espasmodica.

Dolor relacionado con el tracto gastrointestinal, de las vias biliares o el aparato urogenital; dismenorrea.

FARMACOCINETICA Y FARMACODINAMIA EN HUMANOS:

Propifenazona: Aproximadamente 1 hora tras la ingestacion de una (220 mg de propifenazona) o dos (440 mg de propifenazona) grageas de ESPASMO CIBALGINA*, se alcanzan las concentraciones plasmaticas medias maximas de 2 y 6 mg/ml de propifenazona, respectivamente.

La propifenazona se elimina del plasma con una vida media de unas 2 horas.

La incorporacion de la propifenazona a proteinas plasmaticas es de 40% por termino medio.

La propifenazona pasa rapidamente a la saliva. La proporcion de concentracion en la saliva frente a la del plasma es de 0.59 y permanece casi constante.

La concentracion de norpropifenazona (N-2-desmetil-propifenazona), el metabolito principal de propifenazona en el plasma y la saliva, es de alrededor de una decima parte de la propifenazona. No existen datos relativos a la actividad terapeutica de la norpropifenazona.

En 24 horas, menos de 1% de la dosis administrada se excreta por la orina como propifenazona inalterada. El principal metabolito excretado por la orina es el enol glucuronido de N-2-desmetil-propifenazona.

Clorhidrato de drofenina: Su biodisponibilidad tras la administracion oral resulta pobre dado que no se puede detectar su forma inalterada en el plasma o la orina. El metabolito acidico acido ciclohexilfenilactica (CHPAA) se puede detectar en el plasma tras la administracion oral.

En la orina, el CHPAA no es localizable como sustancia inalterada ni conjugada, siendo probablemente metabolizada o excretada a traves de la bilis.

Farmacodinamia: La propifenazona tiene un efecto analgesico, antipiretico y ligeramente antiinflamatorio. El clorhidrato de drofenina tiene accion espasmolitica.

CONTRAINDICACIONES:

Hipersensibilidad a las sustancias activas de ESPASMO CIBALGINA*, asi como a otras pirazolonas (por ejemplo, metamizol, aminofenazona, fenazona) y pirazolidinas (por ejemplo, fenilbutazona).

ESPASMO CIBALGINA* no se administrara a pacientes en los que la Aspirina ® y otros medicamentos antiinflamatorios no esteroides provoquen asma, urticaria u otras reacciones de tipo alergico.

Deficit de glucosa-6-fosfatodeshidrogenasa, porfiria, glaucoma de angulo agudo, estenosis mecanica en el tracto gastrointestinal, megacolon, ileo paralitico, estrenimiento cronico, hipertrofia prostatica con orina residual, taquiarritmias, miastenia grave.

ESPASMO CIBALGINA* no debera administrarse a ninos menores de 14 anos.

PRECAUCIONES GENERALES:

Por razones medicas de indole basica, se tendra precaucion en presencia de trastornos graves de la funcion hepatica y renal.

En pacientes que sufran asma o enfermedades cronicas obstructivas del tracto respiratorio (especialmente si se asocian con fenomenos del tipo de la fiebre del heno), el empleo de ESPASMO CIBALGINA* puede provocar episodios de ataques asmaticos o implicar riesgo de shock.

No puede excluirse la posibilidad de que se produzca un sindrome de Lyell.

Como todos los analgesicos, ESPASMO CIBALGINA* no debe administrarse sin control medico de modo continuo durante periodos prolongados o a dosis mas altas de las recomendadas.

RESTRICCIONES DE USO DURANTE EL EMBARAZO Y LA LACTANCIA:

Durante el embarazo, especialmente en los tres primeros meses, ESPASMO CIBALGINA* solo se empleara cuando sea imprescindible. Los medicamentos que inhiben la prostaglandina-sintetasa tienen la posibilidad de causar inercia uterina y/o cierre precoz del conducto arterioso; por lo cual no se debe administrar ESPASMO CIBALGINA* durante las ultimas semanas de la gestacion.

Las sustancias activas de ESPASMO CIBALGINA* pasan a la leche materna. Por seguridad no se debera administrar ESPASMO CIBALGINA* durante la lactancia.

REACCIONES SECUNDARIAS Y ADVERSAS:

Reacciones de hipersensibilidad:

Raramente: Erupcion cutanea, urticaria, prurito, reacciones anafilacticas-anafilactoides angioedema, broncospasmo y shock.

Raramente: Dolor abdominal, nauseas y vomitos.

Raramente: Taquicardia, excitabilidad e intranquilidad, principalmente en pacientes de edad avanzada.

Casos aislados: Leucopenia y agranulocitosis.

INTERACCIONES MEDICAMENTOSAS Y DE OTRO GENERO:

Se sabe que los medicamentos que actuan sobre las enzimas hepaticas microsomicas modifican la vida media de la propifenazona (por ejemplo, rifampicina, carbamazepina). El clorhidrato de drofenina puede incrementar los efectos anticolinergicos de los alcaloides de la belladona, las antihistaminas, los antidepresivos triciclicos, la amantadina y la quinidina.

ALTERACIONES EN LOS RESULTADOS DE PRUEBAS DE LABORATORIO:

En casos aislados, ESPASMO CIBALGINA* puede afectar al sistema hematopoyetico. Por tanto, en pacientes con discrasia hematica preexistente o en casos excepcionales de empleo prolongado de ESPASMO CIBALGINA* los recuentos hematicos deberan realizarse periodicamente.

PRECAUCIONES EN RELACION CON EFECTOS DE CARCINOGENESIS, MUTAGENESIS, TERATOGENESIS Y SOBRE LA FERTILIDAD:

Los estudios de toxicidad realizados con propifenazona no demostraron carcinogenia, mutagenicidad ni teratogenia. No existen datos experimentales relevantes relativos al clorhidrato de drofenina.

DOSIS Y VIA DE ADMINISTRACION:

Adultos y adolescentes de 14 o mas anos en adelante: 1 gragea 2 a 3 veces al dia.

Via de administracion: Oral.

MANIFESTACIONES Y MANEJO DE LA SOBREDOSIFICACION O INGESTA ACCIDENTAL:

Si se han sobrepasado masivamente las dosis recomendadas, la propifenazona puede provocar los siguientes sintomas a las pocas horas de la toma: nauseas, vomitos, taquicardia, hipotension, somnolencia, confusion, shock, coma, convulsiones. Puede producirse lesion hepatica y renal entre 12 horas y tres dias despues de la ingestion. El clorhidrato de drofenina puede provocar rubor cutaneo y cansancio. Dado que la propifenazona se absorbe de manera completa y rapida en el tracto gastrointestinal, es necesaria una rapida intervencion medica: induccion de vomito o lavado gastrico, administracion de carbon activado y sal de Glauber, asi como medidas estandar para el mantenimiento de las funciones vitales. La diuresis forzada tiene un valor dudoso, dado que las pirazolonas son metabolizadas de manera rapida y extensa.

PRESENTACIONES:

Caja con 10, 20, 24 y 48 grageas para venta al publico.

RECOMENDACIONES SOBRE ALMACENAMIENTO:

Conservese a temperatura ambiente a no mas de 30°C y en lugar seco.

LEYENDAS DE PROTECCION:

No se deje al alcance de los ninos. Literatura exclusiva para medicos. Su venta requiere receta medica.

LABORATORIO Y DIRECCION:

Hecho en Mexico por: NOVARTIS FARMACEUTICA, S. A. de C. V. Calzada de Tlalpan Num. 1779 Colonia San Diego Churubusco 04120 Mexico, D. F. * Marca registrada

Reg. Num. 19717, SSA IV JEAR-209865/RM2001/IPPA

URTICARIA . Existen multiples causas de la urticaria, pero la erupcion se caracteriza siempre por ronchas rojas pruriginosas.

Istin 5 Mg Tablets - Summary Of Product Characteristics (Spc), Istin

4.2 Posology and method of administration

For both hypertension and angina the usual initial dose is 5 mg Istin once daily which may be increased to a maximum dose of 10 mg depending on the individual patient's response.

In hypertensive patients, Istin has been used in combination with a thiazide diuretic, alpha blocker, beta blocker, or an angiotensin converting enzyme inhibitor. For angina, Istin may be used as monotherapy or in combination with other antianginal medicinal products in patients with angina that is refractory to nitrates and/or to adequate doses of beta blockers.

No dose adjustment of Istin is required upon concomitant administration of thiazide diuretics, beta blockers, and angiotensin-converting enzyme inhibitors.

Istin used at similar doses in elderly or younger patients is equally well tolerated. Normal dosage regimens are recommended in the elderly, but increase of the dosage should take place with care (see sections 4.4 and 5.2).

Patients with hepatic impairment

Dosage recommendations have not been established in patients with mild to moderate hepatic impairment; therefore dose selection should be cautious and should start at the lower end of the dosing range (see sections 4.4 and 5.2). The pharmacokinetics of amlodipine have not been studied in severe hepatic impairment. Amlodipine should be initiated at the lowest dose and titrated slowly in patients with severe hepatic impairment.

Patients with renal impairment

Changes in amlodipine plasma concentrations are not correlated with degree of renal impairment, therefore the normal dosage is recommended. Amlodipine is not dialysable.

Children and adolescents with hypertension from 6 years to 17 years of age.

The recommended antihypertensive oral dose in paediatric patients ages 6-17 years is 2.5 mg once daily as a starting dose, up-titrated to 5 mg once daily if blood pressure goal is not achieved after 4 weeks. Doses in excess of 5 mg daily have not been studied in paediatric patients (see sections 5.1 and 5.2).

Children under 6 years old

No data are available.

Method of administration

Tablet for oral administration.

Amlodipine is contraindicated in patients with:

hypersensitivity to dihydropyridine derivatives, amlodipine or to any of the excipients listed in section 6.1.

shock (including cardiogenic shock).

obstruction of the outflow tract of the left ventricle (e. g. high grade aortic stenosis).

haemodynamically unstable heart failure after acute myocardial infarction.

4.4 Special warnings and precautions for use

The safety and efficacy of amlodipine in hypertensive crisis has not been established.

Patients with cardiac failure

Patients with heart failure should be treated with caution. In a long-term, placebo controlled study in patients with severe heart failure (NYHA class III and IV) the reported incidence of pulmonary oedema was higher in the amlodipine treated group than in the placebo group (see section 5.1). Calcium channel blockers, including amlodipine, should be used with caution in patients with congestive heart failure, as they may increase the risk of future cardiovascular events and mortality.

Patients with hepatic impairment

The half-life of amlodipine is prolonged and AUC values are higher in patients with impaired liver function; dosage recommendations have not been established. Amlodipine should therefore be initiated at the lower end of the dosing range and caution should be used, both on initial treatment and when increasing the dose. Slow dose titration and careful monitoring may be required in patients with severe hepatic impairment.

In the elderly increase of the dosage should take place with care (see sections 4.2 and 5.2).

Patients with renal impairment

Amlodipine may be used in such patients at normal doses. Changes in amlodipine plasma concentrations are not correlated with degree of renal impairment. Amlodipine is not dialysable.

4.5 Interaction with other medicinal products and other forms of interaction

Effects of other medicinal products on amlodipine

Concomitant use of amlodipine with strong or moderate CYP3A4 inhibitors (protease inhibitors, azole antifungals, macrolides like erythromycin or clarithromycin, verapamil or diltiazem) may give rise to significant increase in amlodipine exposure resulting in an increased risk of hypotension. The clinical translation of these PK variations may be more pronounced in the elderly. Clinical monitoring and dose adjustment may thus be required.

There is no data available regarding the effect of CYP3A4 inducers on amlodipine. The concomitant use of CYP3A4 inducers (e. g. rifampicin, hypericum perforatum) may give a lower plasma concentration of amlodipine. Amlodipine should be used with caution together with CYP3A4 inducers.

Administration of amlodipine with grapefruit or grapefruit juice is not recommended as bioavailability may be increased in some patients resulting in increased blood pressure lowering effects.

In animals, lethal ventricular fibrillation and cardiovascular collapse are observed in association with hyperkalemia after administration of verapamil and intravenous dantrolene. Due to risk of hyperkalemia, it is recommended that the co-administration of calcium channel blockers such as amlodipine be avoided in patients susceptible to malignant hyperthermia and in the management of malignant hyperthermia.

Effects of amlodipine on other medicinal products

The blood pressure lowering effects of amlodipine adds to the blood pressure-lowering effects of other medicinal products with antihypertensive properties.

There is a risk of increased tacrolimus blood levels when co-administered with amlodipine but the pharmacokinetic mechanism of this interaction is not fully understood. In order to avoid toxicity of tacrolimus, administration of amlodipine in a patient treated with tacrolimus requires monitoring of tacrolimus blood levels and dose adjustment of tacrolimus when appropriate.

No drug interaction studies have been conducted with cyclosporine and amlodipine in healthy volunteers or other populations with the exception of renal transplant patients, where variable trough concentration increases (average 0% - 40%) of cyclosporine were observed. Consideration should be given for monitoring cyclosporine levels in renal transplant patients on amlodipine, and cyclosporine dose reductions should be made as necessary.

Co-administration of multiple doses of 10 mg of amlodipine with 80 mg simvastatin resulted in a 77% increase in exposure to simvastatin compared to simvastatin alone. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily.

In clinical interaction studies, amlodipine did not affect the pharmacokinetics of atorvastatin, digoxin or warfarin.

4.6 Fertility, pregnancy and lactation

The safety of amlodipine in human pregnancy has not been established.

In animal studies, reproductive toxicity was observed at high doses (see section 5.3).

Use in pregnancy is only recommended when there is no safer alternative and when the disease itself carries greater risk for the mother and foetus.

It is not known whether amlodipine is excreted in breast milk. A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy with amlodipine should be made taking into account the benefit of breast-feeding to the child and the benefit of amlodipine therapy to the mother.

Reversible biochemical changes in the head of spermatozoa have been reported in some patients treated by calcium channel blockers. Clinical data are insufficient regarding the potential effect of amlodipine on fertility. In one rat study, adverse effects were found on male fertility (see section 5.3).

4.7 Effects on ability to drive and use machines

Amlodipine can have minor or moderate influence on the ability to drive and use machines. If patients taking amlodipine suffer from dizziness, headache, fatigue or nausea the ability to react may be impaired. Caution is recommended especially at the start of treatment.

4.8 Undesirable effects

Summary of the safety profile

The most commonly reported adverse reactions during treatment are somnolence, dizziness, headache, palpitations, flushing, abdominal pain, nausea, ankle swelling, oedema and fatigue.

Tabulated list of adverse reactions

The following adverse reactions have been observed and reported during treatment with amlodipine with the following frequencies: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000).

Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness.

System organ class

*mostly consistent with cholestasis

Exceptional cases of extrapyramidal syndrome have been reported.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. mhra. gov. uk/yellowcard .

In humans experience with intentional overdose is limited.

Available data suggest that gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to and including shock with fatal outcome have been reported.

Clinically significant hypotension due to amlodipine overdosage calls for active cardiovascular support including frequent monitoring of cardiac and respiratory function, elevation of extremities and attention to circulating fluid volume and urine output.

A vasoconstrictor may be helpful in restoring vascular tone and blood pressure, provided that there is no contraindication to its use. Intravenous calcium gluconate may be beneficial in reversing the effects of calcium channel blockade.

Gastric lavage may be worthwhile in some cases. In healthy volunteers the use of charcoal up to 2 hours after administration of amlodipine 10 mg has been shown to reduce the absorption rate of amlodipine.

Since amlodipine is highly protein-bound, dialysis is not likely to be of benefit.

5. Pharmacological properties

5.1 Pharmacodynamic properties

Pharmacotherapeutic group: Calcium channel blockers, selective calcium channel blockers with mainly vascular effects. ATC Code: C08CA01.

Amlodipine is a calcium ion influx inhibitor of the dihydropyridine group (slow channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle.

The mechanism of the antihypertensive action of amlodipine is due to a direct relaxant effect on vascular smooth muscle. The precise mechanism by which amlodipine relieves angina has not been fully determined but amlodipine reduces total ischaemic burden by the following two actions:

1) Amlodipine dilates peripheral arterioles and thus, reduces the total peripheral resistance (afterload) against which the heart works. Since the heart rate remains stable, this unloading of the heart reduces myocardial energy consumption and oxygen requirements.

2) The mechanism of action of amlodipine also probably involves dilatation of the main coronary arteries and coronary arterioles, both in normal and ischaemic regions. This dilatation increases myocardial oxygen delivery in patients with coronary artery spasm (Prinzmetal's or variant angina).

In patients with hypertension, once daily dosing provides clinically significant reductions of blood pressure in both the supine and standing positions throughout the 24 hour interval. Due to the slow onset of action, acute hypotension is not a feature of amlodipine administration.

In patients with angina, once daily administration of amlodipine increases total exercise time, time to angina onset, and time to 1 mm ST segment depression, and decreases both angina attack frequency and glyceryl trinitrate tablet consumption.

Amlodipine has not been associated with any adverse metabolic effects or changes in plasma lipids and is suitable for use in patients with asthma, diabetes, and gout.

Use in patients with coronary artery disease (CAD)

The effectiveness of amlodipine in preventing clinical events in patients with coronary artery disease (CAD) has been evaluated in an independent, multi-centre, randomized, double-blind, placebo-controlled study of 1997 patients; Comparison of Amlodipine vs. Enalapril to Limit Occurrences of Thrombosis (CAMELOT). Of these patients, 663 were treated with amlodipine 5-10 mg, 673 patients were treated with enalapril 10-20 mg, and 655 patients were treated with placebo, in addition to standard care of statins, beta-blockers, diuretics and aspirin, for 2 years. The key efficacy results are presented in Table 1. The results indicate that amlodipine treatment was associated with fewer hospitalizations for angina and revascularization procedures in patients with CAD.

Table 1. Incidence of significant clinical outcomes for CAMELOT

Abbreviations: CHF, congestive heart failure; CI, confidence interval; MI, myocardial infarction; TIA, transient ischemic attack.

Use in patients with heart failure

Haemodynamic studies and exercise based controlled clinical trials in NYHA Class II-IV heart failure patients have shown that Istin did not lead to clinical deterioration as measured by exercise tolerance, left ventricular ejection fraction and clinical symptomatology.

A placebo controlled study (PRAISE) designed to evaluate patients in NYHA Class III-IV heart failure receiving digoxin, diuretics and ACE inhibitors has shown that Istin did not lead to an increase in risk of mortality or combined mortality and morbidity with heart failure.

In a follow-up, long term, placebo controlled study (PRAISE-2) of Istin in patients with NYHA III and IV heart failure without clinical symptoms or objective findings suggestive or underlying ischaemic disease, on stable doses of ACE inhibitors, digitalis, and diuretics, Istin had no effect on total cardiovascular mortality. In this same population Istin was associated with increased reports of pulmonary oedema.

Treatment to prevent heart attack trial (ALLHAT)

A randomized double-blind morbidity-mortality study called the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was performed to compare newer drug therapies: amlodipine 2.5-10 mg/d (calcium channel blocker) or lisinopril 10-40 mg/d (ACE-inhibitor) as first-line therapies to that of the thiazide-diuretic, chlorthalidone 12.5-25 mg/d in mild to moderate hypertension.

A total of 33,357 hypertensive patients aged 55 or older were randomized and followed for a mean of 4.9 years. The patients had at least one additional CHD risk factor, including: previous myocardial infarction or stroke (> 6 months prior to enrollment) or documentation of other atherosclerotic CVD (overall 51.5%), type 2 diabetes (36.1%), HDL-C < 35 mg/dL (11.6%), left ventricular hypertrophy diagnosed by electrocardiogram or echocardiography (20.9%), current cigarette smoking (21.9%).

The primary endpoint was a composite of fatal CHD or non-fatal myocardial infarction. There was no significant difference in the primary endpoint between amlodipine-based therapy and chlorthalidone-based therapy: RR 0.98 95% CI (0.90-1.07) p=0.65. Among secondary endpoints, the incidence of heart failure (component of a composite combined cardiovascular endpoint) was significantly higher in the amlodipine group as compared to the chlorthalidone group (10.2% vs. 7.7%, RR 1.38, 95% CI [1.25-1.52] p<0.001). However, there was no significant difference in all-cause mortality between amlodipine-based therapy and chlorthalidone-based therapy. RR 0.96 95% CI [0.89-1.02] p=0.20.

Use in children (aged 6 years and older)

In a study involving 268 children aged 6-17 years with predominantly secondary hypertension, comparison of a 2.5 mg dose, and 5.0 mg dose of amlodipine with placebo, showed that both doses reduced Systolic Blood Pressure significantly more than placebo. The difference between the two doses was not statistically significant.

The long-term effects of amlodipine on growth, puberty and general development have not been studied. The long-term efficacy of amlodipine on therapy in childhood to reduce cardiovascular morbidity and mortality in adulthood has also not been established.

5.2 Pharmacokinetic properties

Absorption, distribution, plasma protein binding: After oral administration of therapeutic doses, amlodipine is well absorbed with peak blood levels between 6-12 hours post dose. Absolute bioavailability has been estimated to be between 64 and 80%. The volume of distribution is approximately 21 l/kg. In vitro studies have shown that approximately 97.5% of circulating amlodipine is bound to plasma proteins.

The bioavailability of amlodipine is not affected by food intake.

The terminal plasma elimination half-life is about 35-50 hours and is consistent with once daily dosing. Amlodipine is extensively metabolised by the liver to inactive metabolites with 10% of the parent compound and 60% of metabolites excreted in the urine.

Very limited clinical data are available regarding amlodipine administration in patients with hepatic impairment. Patients with hepatic insufficiency have decreased clearance of amlodipine resulting in a longer half-life and an increase in AUC of approximately 40-60%.

The time to reach peak plasma concentrations of amlodipine is similar in elderly and younger subjects. Amlodipine clearance tends to be decreased with resulting increases in AUC and elimination half-life in elderly patients. Increases in AUC and elimination half-life in patients with congestive heart failure were as expected for the patient age group studied.

A population PK study has been conducted in 74 hypertensive children aged from 1 to 17 years (with 34 patients aged 6 to 12 years and 28 patients aged 13 to 17 years) receiving amlodipine between 1.25 and 20 mg given either once or twice daily. In children 6 to 12 years and in adolescents 13-17 years of age the typical oral clearance (CL/F) was 22.5 and 27.4 L/hr respectively in males and 16.4 and 21.3 L/hr respectively in females. Large variability in exposure between individuals was observed. Data reported in children below 6 years is limited.

5.3 Preclinical safety data

Reproductive studies in rats and mice have shown delayed date of delivery, prolonged duration of labour and decreased pup survival at dosages approximately 50 times greater than the maximum recommended dosage for humans based on mg/kg.

Impairment of fertility

There was no effect on the fertility of rats treated with amlodipine (males for 64 days and females 14 days prior to mating) at doses up to 10 mg/kg/day (8 times* the maximum recommended human dose of 10 mg on a mg/m 2 basis). In another rat study in which male rats were treated with amlodipine besilate for 30 days at a dose comparable with the human dose based on mg/kg, decreased plasma follicle-stimulating hormone and testosterone were found as well as decreases in sperm density and in the number of mature spermatids and Sertoli cells.

Rats and mice treated with amlodipine in the diet for two years, at concentrations calculated to provide daily dosage levels of 0.5, 1.25, and 2.5 mg/kg/day showed no evidence of carcinogenicity. The highest dose (for mice, similar to, and for rats twice* the maximum recommended clinical dose of 10 mg on a mg/m 2 basis) was close to the maximum tolerated dose for mice but not for rats.

Mutagenicity studies revealed no drug related effects at either the gene or chromosome levels.

*Based on patient weight of 50 kg

6. Pharmaceutical particulars

6.1 List of excipients

Mon Chat Est Malade 4 - Forum Soigner Son Chat - Page 4, Dimazon

Mon chat est malade

- Page 4 Bonjour, bonsoir

En cette heure tardive j'espere avoir une reponse.

Mon chat, assez vieux (environ 16 ans) semble malade : Elle ne mange pas (elle a cependant leche un peu de creme fraiche. Oui je sais, le lactose leur est mauvais, mais j'ai essaye pour qu'elle puisse avoir l'estomac au moins un peu rempli)

Elle respire tres fort est bizarrement, les cotes de son ventre rentrent beaucoup, ca fait un creux que l'on sent enormement, des deux cotes

Elle n'aime plus etre prise dans les bras, elle semble avoir mal lorsqu'elle est courbee.

Elle sait marcher, mais a titube. Je ne sais pas si c'est lie a une maladie ou son manque de nourriture (elle a assez peu mange ces derniers temps, mais je ne m'inquietais pas de ca, parfois elle mange comme un cochon, parfois elle mange aussi peu qu'un moineau)

J'ai egalement l'impression que son ventre a gonfle, mais je n'en suis pas sure.

Vous avez des idees de ce que ca peut etre ? Est-ce que c'est la fin ? Tout cela (hormis pour la nourriture) a commence aujourd'hui.. J'aimerai beaucoup la faire dormir dans mon lit, mais j'ai trop peur de me reveiller demain et la voir sans vie.. Vous pensez que je peux ?

Message 25 Inscription 13/12/12

- Page 4 Bonjour, merci Laurence, mais je crois qu'au final ce ne sera pas utile.

Lolop, est-ce que ton chien continuait a marcher. La mienne ne veut plus marcher, et reste tranquillement dans mon lit, toujours dans la meme position, et lorsqu'elle tente de se lecher, elle abandonne immediatement.

L'effet de la piqure n'est restee que 2 jours, je pense que je vais demander a la faire euthanasier.

Message 1635 Inscription 24/05/11

- Page 4 le dimazon est un diuretique donc fait pour eliminer son oedeme mais il faut laisse le temps au medicament d'agir et le fortekor pour le probleme cardiaque et on en donne aussi aux insuffisants renaux. le dimazon commence a faire son effet puisque maintenant elle peut se tenir en position du sphinx alors qu'avant elle ne le pouvait pas et le fait de ne pouvoir faire sa toilette pour l'instant c'est parce qu'elle a encore trop d'eau dans le corps et qu'elle est genee.

Message 2898 Inscription 07/06/11

Comme le dis Ptfelin ne t'alarme pas. tu peux encore faire une visite si tu veux chez le veto aujourd'hui il est 17h20 peut etre aurait elle besoin d'une nouvelle injection je peux pas l'affirmer Ptfetin peut peut etre te le dire. je ne connais pas dimazon du tout. ou passe un coup de fil au veto mais tout ce qui est diuretique necessite du temps meme chez l'humain. alors ne connaissant pas le dimazon du tout je ne peux m'avancer si il est possible d'avoir une deuxieme injection maintenant. effectivement le fait qu'elle essaie de faire sa toilette c'est plutot bon signe et comme la dis Ptfeflin pour le moment elle est genee par l'eau en clair je repete ce qu'il vient de dire. mais ne pense pas a l'euthanasie de suite. tant qu'il y a de la vie il y a de l'espoir. aussi elle a commence a manger. elle est sur le lit elle a besoin de se reposer. cela la fatigue le traitement. allez reprends toi et surtout ne pense pas a l'euthanasie elle risque de le ressentir. donne le temps au temps , La reponse de Lolop t'a peut etre destabilisee mais elle a fait un temoignage de ce qui est arrive a son caniche. combien de fois on m'a dis de me preparer pour chien de 15 ans et 4 mois et j'ai jamais baisse les bras. je vais meme te dire quand il avait 13 ans son ancien veto m'avais dis de me preparer car la limite d'age et de 14 ans dans la race et voulait lui faire une IRM pour savoir si il avait une tumeur au cerveau mais avec le risque qu'il reste sur la table de l'anesthesie et je lui avais dis cela changera quoi de savoir qu'il a une tumeur au cerveau il est inoperable a son age. ensuite j'ai change de veto a qui j'ai raconte l'histoire et qui a ete completement d'accord avec moi. souvent on me dis prepare toi donc cela feras deja 2ans passe que je devrais me preparer et bien j'aurais eu le temps de pleurer. Ne connaissant pas le dimazon soit appelle ton veto pour voir si elle peut avoir une deuxieme injection, mais ne soit jamais defaitiste l'animal le sentira. allez donne nous des bonnes nouvelles avec de l'espoir et concentre toi sur les progres qu'elle a fait .

Courage et espoir

Laurence et son arche de Noe

Message 2898 Inscription 07/06/11

- Page 4 Et je t'assure que les chats ont une resistance enorme face a la maladie. beaucoup plus qu'un chien je l'ai remarque depuis des annees. les chats sauvages que je vois parfois malade. corryza etc arrive a surmonter sans medicaments. certes parfois ils ont des crises mais je peux te dire depuis que je les vois. les chats ont une force de guerison vraiment tres forte. Osiris mon chat aveugle si tu lis son histoire en est la preuve vivante. pourtant pendant les operations il a fait un arret cardiaque. et il est la celui qui est devenu mon chat. mon fils. mon combattant. mon soldat .

Courage et accroche toi et pleins d'energie positive pour ta chatte de la part des mien(nes)

Poste par Ancien utilisateur il y a 1304 jours

- Page 4 Bon je reviens sur ce fil 3 jours apres. Donc je vais repondre au fur et a mesure. Par contre tu es sure que c'est Fortekor 5 car normalement pour un chat c'est Fortekor 2,5 ? Il est important que tu repondes precisement a cette question. Pour le Fortekor qui coute cher (environ 22 euros pour un mois de traitement) tu peux le remplacer (et je suis totalement sure de ce que je dis puisque mon plus vieux chat est sous le meme traitement) tu peux le remplacer par du Benazepril EG 5 mg. Normalement la posologie du Fortekor 2,5 est d'un comprime par jour pour un chat donc la boite qui compte 30 comprimes dure un mois. Alors que le Benazepril 5mg est une boite de 30 comprimes et il n'en faut qu'un demi comprime par jour donc la boite dure 2 mois pour seulement 6 euros. Tu peux verifier sur la boite de Fortekor, il est bien mentionne "Benazepril".

Poste par Ancien utilisateur il y a 1304 jours

- Page 4 Pour donner le medicament, presse sur ses babines et des que sa gueule est ouverte met le comprime pour qu'il aille au fond de son gosier et attend qu'elle ait deglutit.

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Propranolol - Heart Disease, Shinpral

Heart Disease - Shinpral (Brand name: propranolol)

Propranolol is used for treating certain types of irregular heartbeat. It may also be used for other conditions as determined by your doctor.

Use Propranolol as directed by your doctor.

Take Propranolol by mouth with or without food. Ask your health care provider any questions you may have about how to use Propranolol.

Drug Class and Mechanism

Propranolol is a beta-blocker. It works by decreasing the action of pacemaker cells and slowing certain impulses in the heart. This helps to control irregular heartbeat.

If you miss a dose of Propranolol and are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Propranolol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Propranolol out of the reach of children and away from pets.

Do not use Propranolol if:

you are allergic to any ingredient in Propranolol; you have moderate to severe heart block, uncontrolled heart failure, shock caused by serious heart problems, very slow heartbeat with heart block, or very low blood pressure after a heart attack; you have asthma or Raynaud syndrome; the patient is a child with diabetes or heart failure. you are taking mibefradil. Contact your doctor or health care provider right away if any of these apply to you.

Propranolol may cause drowsiness, dizziness, lightheadedness, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use Propranolol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Check with your doctor before you drink alcohol while you are taking Propranolol; it may increase the risk of Propranolol 's side effects. Do not take more than the recommended dose without checking with your doctor. Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms. If you have a history of any severe allergic reaction, talk with your doctor. You may be at risk for an even more severe allergic reaction if you come into contact with the substance that caused your allergy. Some medicines used to treat severe allergies may also not work as well while you are using Propranolol. Propranolol may lower your blood sugar levels. This is most likely to happen in infants and children, or in patients who have diabetes or kidney problems. It may also occur after prolonged physical activity or during fasting. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. If this occurs, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. Diabetes patients - Propranolol may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Propranolol may interfere with certain lab tests, including the glaucoma screening test and dobutamine stress echocardiography. Be sure your doctor and lab personnel know you are using Propranolol. Lab tests, including blood pressure and heart function tests, may be performed while you use Propranolol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Propranolol while you are pregnant. Propranolol is found in breast milk. If you are or will be breast-feeding while you use Propranolol, check with your doctor. Discuss any possible risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

constipation; diarrhea; dizziness; drowsiness; fatigue; lightheadedness; mild pain, swelling, or redness at the injection site; nausea; stomach upset or cramping; trouble sleeping; vomiting; weakness. Seek medical attention right away if any of these severe side effects occur: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; disorientation; fever with aching and sore throat; hallucinations; memory loss; mental or mood changes; numbness or tingling of the hands; persistent or severe vision changes; red, swollen, blistered or peeling skin; severe dizziness; shortness of breath or wheezing; sudden unusual weight gain; swelling of the hands, ankles, or feet, unusual bruising; unusually slow heartbeat; very cold or blue fingers or toes.

Propranolol is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Buy Azitrotek - Azithromycin - Online Without Prescriptions, Azitrotek

Zithromax (Azitrotek)

Zithromax is used for treating mild to moderate infections caused by certain bacteria. It may also be used alone or with other medicines to treat or prevent certain infections in persons with advanced HIV infection. Zithromax is a macrolide antibiotic. It slows the growth of, or sometimes kills, sensitive bacteria by reducing the production of important proteins needed by the bacteria to survive.

Use Zithromax as directed by your doctor.

Take Zithromax by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Do not take an antacid that has aluminum or magnesium in it within 1 hour before or 2 hours after you take Zithromax.

Zithromax works best if it is taken at the same time each day.

To clear up your infection completely, use Zithromax for the full course of treatment. Keep using it even if you feel better in a few days.

If you miss a dose of Zithromax, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zithromax.

Store Zithromax below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zithromax out of the reach of children and away from pets.

Active Ingredient: Azithromycin.

Do NOT use Zithromax if:

you are allergic to any ingredient in Zithromax, to other macrolide antibiotics (eg, erythromycin), or to ketolide antibiotics (eg, telithromycin)

you are taking dofetilide, nilotinib, pimozide, propafenone, or tetrabenazine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Zithromax. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have liver or kidney problems, myasthenia gravis, or abnormal heart rhythms.

Some medicines may interact with Zithromax. Tell your health care provider if you are taking any other medicines, especially any of the following:

Antiarrhythmics (eg, disopyramide, dofetilide ), arsenic, astemizole, cisapride, domperidone, maprotiline, methadone, paliperidone, pimozide, propafenone, quinolone antibiotics (eg, levofloxacin), terfenadine, or tetrabenazine because the risk of heart problems, including irregular heartbeat, may be increased

Nelfinavir because it may increase the risk of Zithromax's side effects

Rifampin because it may decrease Zithromax's effectiveness

Anticoagulants (eg, warfarin), carbamazepine, cyclosporine, digoxin, ergot derivatives (eg, ergotamine), nilotinib, phenytoin, rifampin, theophylline, triazolam, or tyrosine kinase receptor inhibitors (eg, dasatinib) because the risk of their side effects may be increased by Zithromax.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zithromax may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Zithromax may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Zithromax with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Zithromax may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zithromax. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Tell your doctor or dentist that you take Zithromax before you receive any medical or dental care, emergency care, or surgery.

Long-term or repeated use of Zithromax may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Be sure to use Zithromax for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Zithromax only works against bacteria; it does not treat viral infections (eg, the common cold).

Zithromax should not be used in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zithromax while you are pregnant. It is not known if Zithromax is found in breast milk. If you are or will be breast-feeding while you use Zithromax, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; headache; loose stools; nausea; stomach pain; upset stomach; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; changes in hearing or hearing loss; chest pain; eye or vision problems; irregular heartbeat; muscle weakness; pounding in the chest; red, swollen, blistered, or peeling skin; ringing in the ears; seizure; severe diarrhea; stomach cramps/pain; trouble speaking or swallowing; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Prednicen-M Side Effects In Detail, Prednicen-M

Prednicen-M Side Effects

For the Consumer

Applies to prednisone: oral solution, oral syrup, oral tablet, oral tablet delayed release

As well as its needed effects, prednisone (the active ingredient contained in Prednicen-M) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking prednisone, check with your doctor immediately:

More common:

Aggression

agitation

anxiety

blurred vision

decrease in the amount of urine

dizziness

fast, slow, pounding, or irregular heartbeat or pulse

headache

irritability

mental depression

mood changes

nervousness

noisy, rattling breathing

numbness or tingling in the arms or legs

pounding in the ears

shortness of breath

swelling of the fingers, hands, feet, or lower legs

trouble thinking, speaking, or walking

troubled breathing at rest

weight gain

Incidence not known:

Abdominal or stomach cramping or burning (severe)

abdominal or stomach pain

backache

bloody, black, or tarry stools

cough or hoarseness

darkening of skin

decrease in height

decreased vision

diarrhea

dry mouth

eye pain

eye tearing

facial hair growth in females

fainting

fever or chills

flushed, dry skin

fractures

fruit-like breath odor

full or round face, neck, or trunk

heartburn or indigestion (severe and continuous)

increased hunger

increased thirst

increased urination

loss of appetite

loss of sexual desire or ability

lower back or side pain

menstrual irregularities

muscle pain or tenderness

muscle wasting or weakness

nausea

pain in back, ribs, arms, or legs

painful or difficult urination

skin rash

sleeplessness

sweating

trouble healing

trouble sleeping

unexplained weight loss

unusual tiredness or weakness

vision changes

vomiting

vomiting of material that looks like coffee grounds

Minor Side Effects

Some prednisone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:

Increased appetite

Incidence not known:

Abnormal fat deposits on the face, neck, and trunk

acne

dry scalp

lightening of normal skin color

red face

reddish purple lines on the arms, face, legs, trunk, or groin

swelling of the stomach area

thinning of the scalp hair

For Healthcare Professionals

Applies to prednisone: compounding powder, oral delayed release tablet, oral solution, oral tablet

General

Adverse effects have occurred less frequently when minimum dosages were employed. Dosages greater than 10 mg per day have been associated with an increased incidence of adverse events.

Adverse effects of prednisone (the active ingredient contained in Prednicen-M) may be subdivided into those associated with short-term therapy (to three weeks) and those of long-term therapy (> three weeks).

Short-term effects have included sodium retention-related weight gain and fluid accumulation, hyperglycemia and glucose intolerance, hypokalemia, gastrointestinal upset and ulceration, reversible depression of the hypothalamic-pituitary-adrenal (HPA) axis, and mood changes ranging from mild euphoria and insomnia to nervousness, restlessness, mania, catatonia, depression, delusions, hallucinations, and violent behavior.

Long-term effects have included HPA suppression, Cushingoid appearance, hirsutism or virilism, impotence, and menstrual irregularities, peptic ulcer disease, cataracts and increased intraocular pressure/glaucoma, myopathy, osteoporosis, and vertebral compression fractures. [Ref ]

Metabolic

Metabolic side effects have included hypernatremia (rare), hypokalemia, fluid retention, negative nitrogen balance and increased blood urea nitrogen concentration. Glucocorticoids have been reported to decrease the secretion of thyrotropin (TSH). [Ref ]

Cardiovascular

Up to 12% of patients may develop systolic hypertension. Hypertension has been associated with long-term therapy with prednisone (the active ingredient contained in Prednicen-M) and is thought to be due to fluid retention. One author has associated these changes in blood pressure with advancing age. [Ref ]

Cardiovascular side effects have included hypertension and congestive heart failure due to long-term fluid retention and other direct vascular effects. [Ref ]

Endocrine

Endocrine side effects have included glucose intolerance and hyperglycemia. Diabetes-like symptoms may develop in some individuals. Hypothalamic-pituitary-adrenal activity may be suppressed for up to 12 months following long-term therapy with prednisone (the active ingredient contained in Prednicen-M) Cushingoid appearance commonly has occurred with chronic therapy. In addition, hirsutism or virilism, impotence, and menstrual irregularities may occur with chronic therapy. [Ref ]

Corticosteroid therapy may induce glucose intolerance by reducing the utilization of glucose in tissues and increasing hepatic glucose output. Patients on alternate day therapy may exhibit significantly higher serum glucose on the day prednisone is taken. Diabetes mellitus requiring therapy with diet modifications and hypoglycemic agents has developed in some patients.

Adrenal suppression may persist up to twelve months after long-term corticosteroid therapy. Adrenal suppression may be reduced by giving corticosteroids once a day or once every other day. After corticosteroid therapy has been tapered, supplemental corticosteroid therapy during times of stress (illness, surgery, trauma) may be required. [Ref ]

Gastrointestinal

Gastrointestinal adverse effects most commonly have included nausea, vomiting, dyspepsia, and anorexia. Peptic ulcer disease has been associated with long-term corticosteroid therapy, but is relatively uncommon. Routine prophylactic therapy is not warranted in all individuals. Aluminum/magnesium containing antacids generally have been used to manage GI complaints without significant drug interactions. [Ref ]

Gastrointestinal side effects have included gastrointestinal upset, nausea, vomiting, and peptic ulcer disease. Pancreatitis, gastrointestinal perforation and hemorrhage have also been reported. [Ref ]

Immunologic

Immunologic side effects have included impairment of cell-mediated immunity with increased patient susceptibility to bacterial, viral, fungal and parasitic infections. In addition, the immune response to skin tests may be suppressed. [Ref ]

Patients treated with an average of 10 mg per day over several months developed 50% fewer infections compared to those treated with an average of 20 mg per day. Significantly fewer episodes of aseptic necrosis and a trend toward fewer complications in general have been reported with lower dosages. [Ref ]

Musculoskeletal

Corticosteroid myopathy has presented as weakness and wasting of the proximal limb and girdle muscles and generally has been reversible following cessation of therapy.

Corticosteroids inhibit intestinal calcium absorption and increase urinary calcium excretion leading to bone resorption and bone loss. Bone loss of 3% over one year has been demonstrated with prednisolone 10 mg per day. Postmenopausal females are particularly at risk of loss of bone density. Sixteen percent of elderly patients treated with corticosteroids for 5 years may experience vertebral compression fractures. One author reported measurable bone loss over two years in women on concomitant therapy with prednisone (the active ingredient contained in Prednicen-M) 7.5 mg per day and tamoxifen. [Ref ]

Musculoskeletal side effects have included myopathy, osteoporosis, vertebral compression fractures, and aseptic necrosis of bone. Aseptic necrosis has been reported most often to affect the femoral head. [Ref ]

Ocular

In renal transplant patients maintained on prednisone (the active ingredient contained in Prednicen-M) 10 mg per day, 33% developed posterior subcapsular cataracts. Mean time to cataract development was 26 months. Increased intraocular pressure has occurred in 5% of patients. [Ref ]

Ocular side effects have included increased intraocular pressure, glaucoma, and posterior subcapsular cataracts. [Ref ]

Other

Other side effects have included a glucocorticoid withdrawal syndrome which has been associated with abrupt discontinuation of prednisone (the active ingredient contained in Prednicen-M) therapy and may not be associated with adrenal suppression. [Ref ]

Pseudorheumatism, or glucocorticoid-withdrawal syndrome, has occurred upon withdrawal of corticosteroids but was not related to adrenal insufficiency. Patients experienced anorexia, nausea, vomiting, lethargy, headache, fever, arthralgias, myalgias and postural hypotension. Symptoms resolved when corticosteroid therapy was reinstated. [Ref ]

Psychiatric

Psychiatric side effects have included psychoses, behavioral changes, and pseudotumor cerebri. [Ref ]

Hematologic

Hematologic side effects have included thrombocytopenia, lymphopenia, and, platelet alterations resulting in thrombolic events. [Ref ]

Dermatologic

Dermatologic side effects have included easy bruising, ecchymosis, petechiae striae, delayed wound healing, and acne. [Ref ]

References

1. Thomas TP "The complications of systemic corticosteroid therapy in the elderly." Gerontology 30 (1984): 60-5

2. McClements BM, Callender ME "D-penicillamine therapy in patients with HBsAG-negative chronic active hepatitis and major prednisolone-induced adverse effects." J Hepatol 11 (1990): 322-5

3. Yukosuka O, Omata M, Imazeki F, et al "Combination of short-term prednisolone and adenine arabinoside in the treatment of chronic hepatitis B: a controlled study." Gastroenterology 89 (1985): 246-51

4. Swinburn CR, Wakefield JM, Newman SP, Jones PW "Evidence of prednisolone induced mood change ('steroid euphoria') in patients with chronic obstructive airways disease." Br J Clin Pharmacol 26 (1988): 709-13

5. Perry PJ, Tsuang MT, Hwang MH "Prednisolone psychosis: clinical observations." Drug Intell Clin Pharm 18 (1984): 603-9

6. Chan L, French ME, Oliver DO, Morris PJ "High - and low-dose prednisolone." Transplant Proc 13(1 Pt) (1981): 336-8

7. Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42

8. Ratnam KV, Phay KL, Tan CK "Pemphigus therapy with oral prednisolone regimens: a 5 year study." Int J Dermatol 29 (1990): 363-7

9. Greeves JA "Rapid-onset steroid psychosis with very low dosage of prednisolone." Lancet 05/19/84 (1984): 1119-20

10. Morris GC, Egan JG, Jones MK "Hypokalaemic paralysis induced by bolus prednisolone in Graves' disease." Aust N Z J Med 22 (1992): 312

11. Surks MI, Sievert R "Drugs and thyroid function." N Engl J Med 333 (1995): 1688-94

12. Klepikov PV, Kutyrina IM, Tareyeva IE "Steroid-induced hypertension in patients with nephrotic syndrome." Nephron 48 (1988): 286-90

13. Jackson SH, Beevers DG, Myers K "Does long-term low-dose corticosteroid therapy cause hypertension?" Clin Sci 61 (1981): s381-3

14. Swartz SL, Dluhy RG "Corticosteroids: clinical pharmacology and therapeutic use." Drugs 16 (1978): 238-55

15. Lamberts SE, Bruining HA, De Jong FH "Corticosteroid therapy in severe illness." N Engl J Med 337 (1997): 1285-92

16. Greenstone MA, Shaw AB "Alternate day corticosteroid causes alternate day hyperglycaemia." Postgrad Med J 63 (1987): 761-4

17. Messer J, Reitman D, Sacks HS, et al "Association of adrenocorticosteroid therapy and peptic-ulcer disease." N Engl J Med 309 (1983): 21-4

18. "Product Information. Deltasone (prednisone)." Pharmacia and Upjohn, Kalamazoo, MI.

19. Cisneros JR, Murray KM "Corticosteroids in tuberculosis." Ann Pharmacother 30 (1996): 1298-303

20. Body JJ "Low-dose prednisone and increased risk of development of bone metastases." Ann Oncol 7 (1996): 643

21. Need AG, Philcox JC, Hartley TF, Nordin BE "Calcium metabolism and osteoporosis in cortiscosteroid-treated postmenopausal women." Aust N Z J Med 16 (1986): 341-6

22. Powell JR "Steroid and hypokalemic myopathy after corticosteroids for ulcerative colitis. Systemic and tropical application." Am J Gastroenterol 52 (1969): 425-32

23. Fentiman IS, Saad Z, Caleffi M, et al "Tamoxifen protects against steroid-induced bone loss." Eur J Cancer 28 (1992): 684-5

24. Ledford D, Apter A, Brenner AM, Rubin K, Prestwood K, Frieri M, Lukert B "Osteoporosis in the corticosteroid-treated patient with asthma." J Allergy Clin Immunol 102 (1998): 353-62

25. Fordyce MJ, Solomon L "Early detection of avascular necrosis of the femoral head by MRI." J Bone Joint Surg Br 75 (1993): 365-7

26. Mitchison HC, Bassendine MF, Malcolm AJ, et al "A pilot, double-blind, controlled 1-year trial of prednisolone treatment in primary biliary cirrhosis: hepatic improvement but greater bone loss." Hepatology 10 (1989): 420-9

27. Mizuta H, Kubota K, Shiraishi M, Kai K, Nakamura E, Takagi K "Steroid-related bilateral osteonecrosis of the patella." Arthroscopy 9 (1993): 114-6

28. McDonnell PJ, Kerr Muir MG "Glaucoma associated with systemic corticosteroid therapy." Lancet 08/17/85 (1985): 386-7

29. Debnath SC, Abomelha MS, Jawdat M, et al "Ocular side effects of systemic steroid therapy in renal transplant patients." Ann Ophthalmol 19 (1987): 435-7

30. "Multum Information Services, Inc. Expert Review Panel"

It is possible that some side effects of Prednicen-M may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Cef - Closed End Funds, Ceflong

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Amixide-H; Tablet, Sun Pharmaceutical Industries Ltd, Amixide

AMIXIDE-H - Tablet, Sun Pharmaceutical Industries Ltd.

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Pms-Lamotrigine - Uses, Side Effects, Interactions, Pms-Lamotrigine

pms-Lamotrigine

How does this medication work? What will it do for me?

Lamotrigine belongs to a class of medications known as antiepileptics . It is used alone or in combination with other medications to manage seizures associated with epilepsy when other medications have not been effective or have been stopped. It is also used along with other medications to manage seizures associated with Lennox-Gastaut syndrome . Lamotrigine works by decreasing the chemicals in the brain that are believed to contribute to seizures.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

25 mg Each white-to-off-white, shield-shaped tablet, debossed "P" "25" on one side and scored on the other side, contains lamotrigine 25 mg. Nonmedicinal ingredients . cellulose, lactose, magnesium stearate, povidone, and sodium starch glycolate.

100 mg Each peach, shield-shaped tablet, debossed "P" "100" on one side and scored on the other side, contains lamotrigine 100 mg. Nonmedicinal ingredients . lactose, magnesium stearate, povidone, sodium starch glycolate and FD&C Yellow No. 6 Lake 17.

150 mg Each cream-coloured, shield-shaped tablet, debossed "P" "150" on one side and scored on the other side, contains lamotrigine 150 mg. Nonmedicinal ingredients . lactose, magnesium stearate, povidone, sodium starch glycolate, and Yellow 10 Iron Oxide.

How should I use this medication?

The recommended dose of lamotrigine varies according to a person's need and the other antiepileptic medications they are taking. In adults, lamotrigine is started at a low dose, ranging from 25 mg every other day to 50 mg once a day. Over a number of weeks, the dose is gradually increased until a maintenance dose is reached. The maintenance dose ranges from 50 mg to 250 mg twice a day. For children, lamotrigine is given according to the weight of the child. It should not be used in children who weigh less than 9 kg.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

The regular tablets must be swallowed whole and not chewed or crushed. The chewable tablets may be swallowed whole, chewed, or dissolved in a teaspoonful of water or fruit juice. The tablets take about 1 minute to dissolve. Once dissolved, swirl the solution and drink the entire amount immediately. Add some water to the glass and drink that as well to make sure there is no medicine left in the glass.

Lamotrigine may be taken with or without food.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If your next dose is less than 4 hours away, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. If you miss more than a few days of lamotrigine doses, talk to your doctor before restarting the medication. You may need to start taking the medication at a lower dose than you were taking previously.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e. g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take this medication if you are allergic to lamotrigine or any ingredients of the medication.

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

difficulty sleeping

dizziness

drowsiness

headache

nasal congestion

nausea

stomach upset

vomiting

weakness

weight gain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

blurred vision or other changes in vision

clumsiness or unsteadiness

confusion

continuous, uncontrolled back-and-forth or rolling eye movements

double vision

flu-like symptoms (e. g. fever, chills, or sore throat)

hallucinations (seeing or hearing things that aren't there)

itching

itchy eyes, with discharge

memory loss

mood or mental changes (e. g. agitation, anxiety, aggression, irritability or nervousness)

nightmares

signs of anemia (low red blood cells; e. g. pale skin, unusual tiredness or weakness)

signs of depression (e. g. poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)

signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)

signs of liver problems (e. g. nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)

skin rash

swelling of the hands, feet, ankles (if you are not having difficulty breathing)

swollen glands in the armpit, neck, or groin, or facial swelling

tremor

Stop taking the medication and seek immediate medical attention if any of the following occur:

chest pain

increase in seizures

signs of an allergic reaction (such as difficulty breathing; hives; or swelling of the face, tongue, or throat)

signs of bleeding (such as easy bruising, bleeding gums, nosebleeds, vomiting blood, blood in the urine, dark tarry stools)

signs of meningitis not caused by infection (e. g. headache [severe], throbbing, or with stiff neck or back)

signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

swelling of the hands or feet with shortness of breath

thoughts of suicide or harming yourself

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.

Aseptic meningitis: Rarely, lamotrigine can cause symptoms of aseptic meningitis (inflammation or swelling of the membranes around the brain and spinal cord that is not caused by bacteria). If you have an autoimmune condition (e. g. systemic lupus erythematosus, mixed connective tissue disease), you are more at risk for developing this. If you experience symptoms such as stiff neck, severe headache, nausea, vomiting, fever, or changes in consciousness, stop taking this medication can get immediate medical attention.

Birth control pills/hormone replacement therapy: The dose of lamotrigine you take may need to be adjusted if you start or stop oral contraceptives or other female hormonal treatments, such as hormone replacement therapy.

According to some case reports, when lamotrigine was taken in combination with birth control pills or other hormone replacement, rarely seizures, unexpected pregnancies, and menstrual bleeding disorders (e. g. breakthrough bleeding) occurred.

Do not start or stop taking these medications without consulting your doctor. If you experience changes in your menstrual pattern such as breakthrough bleeding while taking lamotrigine with these medications, contact your doctor.

Drowsiness/reduced alertness: If you have uncontrolled epilepsy, you should not drive or handle potentially dangerous machinery. Common side effects of lamotrigine include dizziness, problems with muscle coordination, drowsiness, double vision, and blurred vision. You should not to undertake activities requiring mental alertness or physical coordination until you determine how lamotrigine affects you.

Heart disease: Lamotrigine can cause a change in the rhythm of the heart, particularly for people who already have certain heart conditions. If you have any heart condition, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Hypersensitivity reaction: Lamotrigine has occasionally caused a hypersensitivity reaction that may be life-threatening or fatal. If you experience any rash, swelling of the face or lymph nodes around the neck, contact your doctor immediately.

Kidney function: Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have reduced liver function or liver disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

This medication may also cause a decrease in liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Rashes: Severe skin rashes leading to hospitalization have been reported by people taking lamotrigine. This appears more likely to happen if the dose is increased too quickly. The risk of a serious rash is higher for children and may be higher for people who have experienced rashes when taking other medication for epilepsy. Nearly all cases of serious rashes associated with lamotrigine have occurred within 2 to 8 weeks of the start of treatment. If you notice a skin rash, fever, or swollen glands, seek medical attention immediately.

Stopping the medication: Suddenly stopping any antiepileptic medication may cause rebound seizures. In general, the medication should be stopped gradually, as directed by your doctor, to minimize this risk. Before stopping lamotrigine, contact your doctor for guidance.

Suicidal or agitated behaviour: People with epilepsy sometimes experience depression. If you have depression or bipolar disorder, you may be at an increased risk of feeling agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or wanting to hurt yourself or others. If you experience these side effects or notice them in a family member who is taking this medication, contact your doctor immediately.

Pregnancy: The use of lamotrigine during pregnancy has been associated with an increased number of cases of cleft palate, a birth defect. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Do not stop taking the medication until you've consulted your doctor, since doing so can cause rebound seizures that may be harmful to the mother and unborn baby.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking lamotrigine, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding. Generally, breast-feeding while taking lamotrigine is not recommended.

Children: The safety and effectiveness of using lamotrigine for children under 16 years of age, other than those with Lennox-Gastaut syndrome, have not been established.

What other drugs could interact with this medication?

There may be an interaction between lamotrigine and any of the following:

alcohol

antihistamines (e. g. cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)

antipsychotics (e. g. chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)

aripiprazole

azelastine

baclofen

barbiturates (e. g. butalbital, phenobarbital)

benzodiazepines (e. g. alprazolam, diazepam, lorazepam)

birth control pills

brimonidine

buprenorphine

buspirone

carbamazepine

chloral hydrate

desmopressin

divalproex sodium

dofetilide

droperidol

efavirenz

entacapone

estrogens (e. g. conjugated estrogen, estradiol, ethinyl estradiol)

gabapentin

fosphenytoin

gabapentin

guanfacine

ketorolac

levetiracetam

magnesium sulfate

mefloquine

metformin

methotrimeprazine

metyrosine

mirtazapine

muscle relaxants (e. g. cyclobenzaprine, methocarbamol, orphenadrine)

narcotic pain relievers (e. g. codeine, fentanyl, morphine, oxycodone)

olopatadine

orlistat

oxcarbazepine

paraldehyde

perampanel

phenytoin

pramipexole

pregabalin

primidone

procainamide

progestins (e. g. dienogest, levonorgestrel, medroxyprogesterone, norethindrone)

rifampin

ritonavir

ropinirole

rotigotine

scopolamine

selective serotonin reuptake inhibitors (SSRIs; e. g. citalopram, duloxetine, fluoxetine, paroxetine, sertraline)

sodium oxybate

tapentadol

tetrabenazine

tolcapone

topiramate

tramadol

tricyclic antidepressants (e. g. amitriptyline, clomipramine, desipramine, trimipramine)

valproic acid

zolpidem

zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,

change one of the medications to another,

change how you are taking one or both of the medications, or

leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

More on Body and Health

Acai Uses, Benefits - Dosage - Herbal Database, Acai Extract

Scientific Name(s): Euterpe oleracea Mart. Family: Arecaceae.

Common Name(s): Acai. acai palm. assai palm. cabbage palm. palma manaca

Uses

Antioxidant and anti-inflammatory activity of acai has been documented. Folk medicinal uses include treatment of fever, pain, and flu. The fruit's dark green oil has been used as an antidiarrheal agent. However, there is a lack of clinical information to recommend acai for any use.

Dosing

Numerous dosage forms are available including juices, powders, capsules, liquids, creams, and lotions. Capsule dosage guidelines are typically 1,000 mg once or twice daily with food. Follow manufacturers' suggested regimen.

Contraindications

Avoid use if hypersensitivity to any acai palm components exists.

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

None well documented.

Adverse Reactions

Toxicology

Botany

Acai, a member of the genus Euterpe. is indigenous to Central and South America and grows in the Amazon estuary as well as in swamps, upland regions, and floodplains. 1. 2. 3 The acai palm is tall and slender, growing 15 to 30 m in height. The leaves are feather-like or pinnate in shape and grow up to 3 m in length. 4 The plant is multistemmed and produces 3 to 4 bunches of round fruits 1 to 1.5 cm in diameter, with each bunch of fruit weighing 3 to 6 kg. The fruits appear in green clusters when immature and ripen to a dark purple color. Each acai fruit contains a seed that accounts for nearly 90% of its weight and diameter. The seeds are covered with a fibrous layer under which is a small edible layer. Although the fruits may be harvested throughout the year, the highest yields are obtained during the dry months of August through December versus the rainy months of January through July. 4. 5

History

The fruit is of economic value; its juice is used to produce jelly, syrup, liquor, ice cream, energy drinks, and a variety of other beverages. 4 Approximately 110,000 tons of fruit yield 100,000 tons of acai seeds commercially every year in the city of Belem, Brazil, alone. 1. 2. 5 The frozen aqueous extract has been exported to numerous countries including the United States, Japan, the Netherlands, and Italy. 6 The fruit also serves as a major food source for people indigenous to Brazil, Colombia, and Suriname. Folk medicinal uses include treatment of fever, pain, and flu. The fruit's dark green oil has been used as an antidiarrheal agent. 3

Heart of palm is a vegetable harvested from the inner core of various palm trees, including acai palm. It is considered a delicacy and is consumed pickled and in salad. 7 The extraction of the heart of palm may lead to the death of the entire tree, which has economic implications; however, research has been undertaken to explore alternative solutions. 8. 9 The scale of illegal palm heart harvesting is difficult to estimate. 9

There are numerous commercial acai products. Most claim antioxidant and antiaging properties. 10 Topical formulations are promoted for inflammatory skin conditions, such as acne, and in hair restoration treatments. 10. 11 Acai is used in cold and flu products and as a functional pigment for yogurt. 12

Chemistry

The primary medicinal part of the plant is the fruit or berry. Numerous studies have been completed on the nutritional composition and chemistry of the fruit. Acai fruit and berries contain lipids (49.4% and 33.1%), proteins (13.8% and 9.3%), ash (5.2% and 2.2%), and total dietary fiber (27.3% and 18%), respectively. 13

Another study on freeze-dried acai fruit identified 19 amino acids, making up 7.6% of total weight. Oleic acid (54%), palmitic acid (27%), and linoleic acid (12%) were the 3 dominant fatty acids. Nutrient analysis of 100 g of powder found 534 calories, 52 g carbohydrates, 8 g protein, 33 g total fat, and 44 g fiber. Vitamins A, B 1 . and C are present, as well as calcium and iron. Five sterols have also been isolated. The major phytochemicals include anthocyanins, proanthocyanidins, and other flavonoids, which are most likely associated with antioxidant activity. Cyandin 3-glucoside and cyanidin 3-rutinoside are the 2 predominant anthocyanins. 3. 7. 14 Total analysis of all flavonoids in the fruit pulp 7 and antioxidant capacity of the seed extract 5 is documented.

Color and stability studies of acai in food, beverage, and nutraceutical products are also available. 4. 15 Due to acai's deep pigmentation, it has been examined as an alternative oral contrast agent for imaging of the GI tract, GI motility, and evaluation of dyspepsia. 16

Uses and Pharmacology

Antioxidant and anti-inflammatory activity of acai has been studied.

Anticancer activity In vitro

Acai fractions containing polyphenolic compounds reduced the proliferation of HL-60 leukemia cells through caspase-3 activation in a dose - and time-dependent manner. The mechanism of action is associated with polyphenolic phytochemicals activating caspase-3, leading to cell death or apoptosis. 17

Anti-inflammatory and antioxidant activity In vitro

The total oxygen scavenging capacity of acai was high against peroxyl radicals, good for peroxynitrite, and mild for hydroxyl radicals when compared with other European fruit and vegetable juices. 18. 19

The freeze-dried powder showed high antioxidant capacity against superoxide, the initial producer of potent reactive oxygen species, and peroxyl scavenging in a superoxide dismutase assay. Acai also inhibited cyclooxygenase enzymes COX-1 and COX-2, with greater effect on COX-1. Antioxidant molecules from acai also entered human neutrophils and inhibited oxidation induced by reactive oxygen species. 20

Acai extracts inhibited lipopolysaccharide and interferon gamma-induced nitric oxide (NO) production in a macrophage cell line. Overproduction of NO may lead to activation of NO synthase, leading to the generation of cells mediating inflammatory processes. The mechanism of action is associated with inhibition of NO synthase expression and activity. 10

The antioxidant activities of the seeds are similar to those of the berries against peroxyl radicals. However, the seeds have a stronger antioxidant effect against peroxynitrite and hydroxyl radicals when compared with the berries. 5

Other pharmacological activity Digestive enzyme inhibition

Proteins from acai fruit pulps inhibited salivary alpha-amylase in vitro. 21

Iron in acai fruits was not effective in improving hemoglobin concentrations in a rat study. 22

An ethanol extract of acai palm fruit peel inhibited testosterone 5-alpha reductase. In patients with an enlarged prostate, dysuria was prevented by the administration of 2 tablets per day (80 mg of acai palm fruit peel extract powder per tablet) for 1 month. 23

Acai induced an endothelium-dependent vasodilator effect in a rat mesenteric vascular bed. The mechanism of action appeared to be dependent on activation of NO-GMPc pathway and may involve endothelium-derived hyperpolarizing factor release. 6

Dosage

Numerous dosage forms are available including juices, powders, capsules, liquids, creams, and lotions. Capsule formulation dosage guidelines are typically 1,000 mg once or twice daily with food. Follow manufacturers' suggested regimen.

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

No drug-drug or drug-food interaction data could be found.

Adverse Reactions

Avoid use if hypersensitivity to any acai palm components exist. No adverse reaction data was found.

Toxicology

No toxicology data has been published.

Bibliography

1. Brondizio E. Safar C. Siqueira A. The urban market of acai fruit ( Euterpe oleracea Mart.) and rural land use change: ethnographic insights into the role of price and land tenure constraining agricultural choices in the Amazon estuary. Urban Ecosyst. 2002 ; 6 ( 1/2 ): 67-97 . 2. Weinstein S. Moegenburg S. Acai palm management in the Amazon estuary: course for conservation or passage to plantations? Conserv Soc. 2004 ; 2 ( 2 ): 316-346 . 3. Schauss AG. Wu X. Prior RL. et al. Phytochemical and nutrient composition of the freeze-dried amazonian palm berry, Euterpe oleraceae Mart. (acai). J Agric Food Chem. 2006 ; 54 ( 22 ): 8598-8603 . 4. Del Pozo-Insfran D. Brenes CH. Talcott ST. Phytochemical composition and pigment stability of Acai ( Euterpe oleracea Mart.). J Agric Food Chem. 2004 ; 52 ( 6 ): 1539-1545 . 5. Rodrigues RB. Lichtenthaler R. Zimmermann BF. et al. Total oxidant scavenging capacity of Euterpe oleracea Mart. (acai) seeds and identification of their polyphenolic compounds. J Agric Food Chem. 2006 ; 54 ( 12 ): 4162-4167 . 6. Rocha AP. Carvalho LC. Sousa MA. et al. Endothelium-dependent vasodilator effect of Euterpe oleracea Mart. (Acai) extracts in mesenteric vascular bed of the rat. Vascul Pharmacol. 2007 ; 46 ( 2 ): 97-104 . 7. Gallori S. Bilia A. Bergonzi M. Barbosa W. Vincieri F. Polyphenolic constituents of fruit pulp of Euterpe oleracea Mart. (Acai palm). Chromatographia. 2004 ; 59 ( 11-12 ): 739-743 . 8. Dyer AP. Latent energy in Euterpe oleracea. In: Biomass for Energy and the Environment, Proceedings of the 9th European Bioenergy Conference; June 24-27, 1996 ; Copenhagen. 9. Galetti M. Fernandez JC. Palm heart harvesting in the Brazilian Atlantic forest: changes in industry structure and the illegal trade. J Appl Ecol. 1998 ; 35 ( 2 ); 294-301 . 10. Matheus ME. de Oliveira Fernandes SB. Silveira CS. Rodrigues VP. de Sousa Menezes F. Fernandes PD. Inhibitory effects of Euterpe oleracea Mart. on nitric oxide production and iNOS expression. J Ethnopharmacol. 2006 ; 107 ( 2 ): 291-296 . 11. Coyado K. Hair restoration treatment with active ingredients from Rain Forests Specialities and other Brazilian plants. NutraCos. 2006 ; 5 ( 1 ): 10-13 . 12. Coïsson JD. Travaglia F. Piana G. Capasso M. Arlorio M. Euterpe oleracea juice as a functional pigment for yogurt. Food Res Int. 2005 ; 38 ( 8-9 ): 893-897 . 13. Neida S. Elba S. Characterization of the acai or manaca ( Euterpe oleracea Mart.): a fruit of the Amazon [in Spanish]. Arch Latinoam Nutr. 2007 ; 57 ( 1 ): 94-98 . 14. Costa D. Presence of vitamin B1 in Euterpe oleracea. Rev Aliment (Rio de Janeiro). 1945 ; 9 ( 9 ): 10-11 . 15. Vera de Rosso V. Mercadante AZ. Evaluation of colour and stability of anthocyanins from tropical fruits in an isotonic soft drink system. Innov Food Sci Emerg Technol. 2007 ; 8 ( 3 ): 347-352 . 16. Córdova-Fraga T. de Araujo DB. Sanchez TA. et al. Euterpe olerácea (açai) as an alternative oral contrast agent in MRI of the gastrointestinal system: preliminary results. Magn Reson Imaging. 2004 ; 22 ( 3 ): 389-393 . 17. Del Pozo-Insfran D. Percival SS. Talcott ST. Açai ( Euterpe oleracea Mart.) Polyphenolics in their glycoside and aglycone forms induce apoptosis of HL-60 leukemia cells. J Agric Food Chem. 2006 ; 54 ( 4 ); 1222-1229 . 18. Lichtenthaler R. Rodrigues RB. Maia JG. Papagiannopoulos M. Fabricius H. Marx F. Total oxidant scavenging capacities of Euterpe oleracea Mart. (Acai) fruits. Int J Food Sci Nutr. 2005 ; 56 ( 1 ): 53-64 . 19. Hassimotto NM. Genovese MI. Lajolo FM. Antioxidant activity of dietary fruits, vegetables, and commercial frozen fruit pulps. J Agric Food Chem. 2005 ; 53 ( 8 ): 2928-2935 . 20. Schauss AG. Wu X. Prior RL. et al. Antioxidant capacity and other bioactivities of the freeze-dried Amazonian palm berry, Euterpe oleraceae mart. (acai). J Agric Food Chem. 2006 ; 54 ( 22 ): 8604-8610 . 21. Araujo CL. Bezerra IW. Dantas IC. et al. Biological activity of proteins from pulps of tropical fruits. Food Chem. 2003 ; 85 ( 1 ): 107-110 . 22. Toalari SD. Yuyama LK. Agular JP. Souza RF. Iron bioavailability from acai ( Euterpe oleracea Mart.) and iron-fortified cassava flour in rats. Rev Nutr. 2005 ; 18 ( 3 ): 291-299 . 23. Katagiri M. Ono A. Oide K. Testosterone 5-alpha-reductase inhibitors containing Euterpe oleracea fruit extracts and their use for treatment of prostatomegaly and for foods and beverages. Jpn Kokai Tokkyo Koho. JP 2006 182701, 20060713, 2004377985, 20041227, 8 pp.

Copyright © 2009 Wolters Kluwer Health

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Campus Access Guide, Niterey

The Nitery (Building 590) is located at 514 Lasuen Mall. It is adjacent to Old Union and directly across from the Bookstore in White Plaza.

The Nitery houses the Catholic Community Center, El Centro Chicano, the Nitery Theater, and the Stanford Chaparral. There are also multiple meeting rooms in the building.

3. Accessible Entrances

The Nitery has several accessible entrances. The south entrance, accessible via a ramp from the center courtyard of Old Union, is equipped with a power-operated door. Once inside (level 1A), the Nitery Theater is directly to the left, and the elevator is located a short distance to the right. Once inside the elevator, all (A) levels open on the panel side of the elevator and all (B) levels open opposite the panel. The elevator accesses the following levels:

1A: Access to Nitery Theater

1B: Access to various meeting rooms

2A: Access to various meeting rooms

2B: Access to various meeting rooms

GA: Access to wheelchair lift to lowest level of Nitery.

GB: Access to various meeting rooms / offices

Another accessible entrance is located on the east side of the building via an accessible pathway from White Plaza. Once inside (level GB), the elevator is a short distance and to the right.

Wheelchair accessible men's and women's restrooms are located on level GA. A wheelchair accessible unisex restroom is located on level 2A to the left once off the elevator.

5. Parking & Transportation

The closest disabled parking is located along Panama Mall to the north of the Nitery. Additional disabled parking is located in a small parking lot between Old Union and the Daily building and on Santa Teresa Street, near the Fire Truck House. There is a Marguerite shuttle stop on Lagunita Drive, at Tresidder Union.

6. Points of Interest

Old Union houses the Axe and Palm, a new favorite place to eat for students. The Axe and Palm serves a wide variety of foods, ranging from breakfast to desserts.

Feldene Indications, Side Effects, Warnings, Feldegel

Feldene

Feldene is a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, heart attack, stroke). The risk may be greater if you already have heart problems or if you take Feldene for a long time. Do not use Feldene right before or after bypass heart surgery.

Feldene may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs.

Feldene is used for:

Treating rheumatoid arthritis or osteoarthritis. It may also be used for other conditions as determined by your doctor.

Feldene is an NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Do NOT use Feldene if:

you are allergic to any ingredient in Feldene

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you are in the last 3 months of pregnancy

you have active stomach or bowel bleeding

you are having problems becoming pregnant or you are having your fertility checked

Contact your doctor or health care provider right away if any of these apply to you.

Before using Feldene:

Some medical conditions may interact with Feldene. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders (eg, porphyria), bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, or if you smoke, you drink alcohol, or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Feldene. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), heparin, rivaroxaban, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Probenecid because it may increase the risk of Feldene's side effects

Cholestyramine because it may decrease Feldene's effectiveness

Bisphosphonates (eg, alendronate, risedronate), cyclosporine, hydantoins (eg, phenytoin), lithium, methotrexate, quinolones (eg, ciprofloxacin), sulfonamides (eg, sulfamethoxazole), or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Feldene

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Feldene

This may not be a complete list of all interactions that may occur. Ask your health care provider if Feldene may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Feldene:

Use Feldene as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Feldene comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Feldene refilled.

Take Feldene by mouth. It may be taken with food if it upsets your stomach. This may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor if you have persistent stomach upset.

Take Feldene with a full glass (8 oz [240 mL]) of water as directed by your doctor.

If you miss a dose of Feldene and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Feldene.

Important safety information:

Tell your doctor or dentist that you take Feldene before you receive any medical or dental care, emergency care, or surgery.

Serious stomach ulcers or bleeding can occur with the use of Feldene. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Feldene with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Feldene may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.

Feldene is an NSAID. Before you start taking any new medicine, read the ingredients. If it also has an NSAID (eg, ibuprofen) in it, check with your doctor. If you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Feldene unless your doctor tells you to.

A severe skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have symptoms like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

Severe and sometimes fatal liver problems have happened with this drug. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

Have an eye exam as you have been told by your doctor.

Feldene may lead to high blood pressure. Have your blood pressure checked as you have been told by your doctor.

Lab tests may be performed while you use Feldene. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Feldene with caution in the ELDERLY; they may be more sensitive to its effects, including stomach bleeding and kidney problems.

NSAIDs like Feldene may affect egg release (ovulation) in women. This may cause you to not be able to get pregnant. This goes back to normal when this drug is stopped. Discuss any questions or concerns with your doctor.

Feldene should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING: Feldene may harm the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Feldene while you are pregnant. Feldene is found in breast milk. If you are or will be breast-feeding while you use Feldene, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Feldene:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; ringing in the ears; seizures; severe or persistent headache or dizziness; severe or persistent stomach pain, nausea, or vomiting; shortness of breath; sudden or unexplained weight gain; swelling of the hands, legs, or feet; symptoms of bleeding (eg, vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; unusual vaginal bleeding; bruises without a reason or that get bigger; any bleeding that is severe or that you cannot stop); symptoms of kidney problems (eg, blood in the urine, change in the amount of urine produced); unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www. aapcc. org ), or emergency room immediately.

Proper storage of Feldene:

Store Feldene at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Feldene out of the reach of children and away from pets.

General information:

If you have any questions about Feldene, please talk with your doctor, pharmacist, or other health care provider.

Feldene is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Feldene or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Feldene. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Feldene. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Feldene.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about Feldene (piroxicam)

Buy Pharmaclofen Baclofen Online Without Prescriptions, Pharmaclofen

Lioresal (Pharmaclofen)

Lioresal (Baclofen) is a muscle relaxer and an antispastic agent.

Baclofen is used to treat muscle symptoms caused by multiple sclerosis, including spasm, pain, and stiffness.

Baclofen may also be used for purposes not listed in this medication guide.

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results. Call your doctor if your muscle symptoms do not improve after 2 weeks of taking this medication. Do not stop taking this medication without first talking to your doctor. You may have withdrawal symptoms such as seizures or hallucinations, when you stop using baclofen after using it over a long period of time. You may need to use less and less before you stop the medication completely.

Take the medicine as directed by your doctor.

Adult Patients with Spasticity of Spinal Cord Origin: After the first 24 hours, for adult patients, the daily dosage should be increased slowly by 10- 30% increments and only once every 24 hours, until the desired clinical effect is achieved.

Adult Patients with Spasticity of Cerebral Origin: After the first 24 hours, the daily dose should be increased slowly by 5- 15% only once every 24 hours, until the desired clinical effect is achieved.

Pediatric Patients: After the first 24 hours, the daily dose should be increased slowly by 5-15% only once every 24 hours, until the desired clinical effect is achieved. If there is not a substantive clinical response to increases in the daily dose, check for proper pump function and catheter patency. Patients must be monitored closely in a fully equipped and staffed environment during the screening phase and dose - titration period immediately following implant. Resuscitative equipment should be immediately available for use in case of life - threatening or intolerable side effects.

Does not require refrigeration.

Do not store above 86°F (30°C).

Do not heat sterilize.

Active ingredient: Baclofen

Lioresal is a muscle relaxant. It reduces the frequency and severity of muscle spasms that occur as a result of neurological disorders such as multiple sclerosis.

You should not use baclofen if you are allergic to it.

To make sure you can safely take baclofen, tell your doctor if you have any of these other conditions:

epilepsy or other seizure disorder; or

a history of stroke or blood clots.

Using baclofen may increase your risk of developing an ovarian cyst. Talk with your doctor about your specific risk. FDA pregnancy category C. It is not known whether baclofen will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether baclofen passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using baclofen. Do not give this medication to a child younger than 12 years old. Older adults may be more sensitive to the effects of this medicine.

Important safety information

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of baclofen. Do not use baclofen at a time when muscle tone is needed to assure safe balance and movement for certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

confusion, hallucinations; or

an uneven heartbeat.

Less serious side effects may include:

drowsiness, dizziness, weakness, tired feeling;

sleep problems (insomnia);

nausea, constipation; or

urinating more often than usual.

This is not a complete list of side effects and others may occur.

Call your doctor for medical advice about side effects.

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Misoprostol Medlineplus Drug Information, Misoprostolum

Misoprostol

Do not take misoprostol to prevent ulcers if you are pregnant or plan to become pregnant. Misoprostol may cause miscarriages, premature labor, or birth defects.

If you are a woman of childbearing age, you may take misoprostol to prevent ulcers only if you have had a negative pregnancy test in the past 2 weeks and if you use a reliable method of birth control while taking misoprostol. You must begin taking misoprostol on the second or third day of your menstrual period. If you become pregnant while taking misoprostol, stop taking it and call your doctor immediately.

Before taking misoprostol, ask your pharmacist or doctor for a copy of the manufacturer's information for the patient and read it carefully. Talk to your doctor about the risks of taking misoprostol.

Do not let anyone else take your medication, especially a woman who is or may become pregnant.

Why is this medication prescribed?

Misoprostol is used to prevent ulcers in people who take certain arthritis or pain medicines, including aspirin, that can cause ulcers. It protects the stomach lining and decreases stomach acid secretion.

Azigram, Azigram

Azigram

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Diabamyl, Diabamyl

Diabetes - Diabamyl (Brand name: metformin)

Metformin is used for treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other anti-diabetic medicines.

Use Metformin as directed by your doctor.

Take Metformin by mouth with food. Take Metformin on a regular schedule to get the most benefit from it. Taking Metformin at the same time each day will help you remember to take it. Continue taking Metformin even if you feel good. Do not miss any doses. Ask your health care provider any questions you may have about its usage.

Drug Class and Mechanism

Metformin is a biguanide antidiabetic. It works by decreasing the amount of sugar that the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.

If you miss a dose of Metformin and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Metformin between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Metformin out of the reach of children and away from pets.

Do not use Metformin if:

you are allergic to any ingredient in Metformin; you have congestive heart failure that is treated by medicine; you have a severe infection, low blood oxygen levels, kidney or liver problems, high blood ketone or acid levels (e. g. diabetic ketoacidosis), or severe dehydration; you have had a stroke or a recent heart attack, or you are in shock; you are 80 years old or older and have not had a kidney function test; you will be having surgery or certain lab procedures. Contact your doctor or health care provider right away if any of these apply to you.

Important : Dizziness may occur while you are taking Metformin. This effect may be worse if you take it with alcohol or certain medicines. Use Metformin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Follow the diet and exercise program given to you by your health care provider. Do not drink large amounts of alcohol while you use Metformin. Talk to your doctor or health care provider before you drink alcohol while you use Metformin. Tell your doctor or dentist that you take Metformin before you receive any medical or dental care, emergency care, or surgery. Be careful not to become dehydrated, especially during hot weather or while you are being active. Dehydration may increase the risk of Metformin 's side effects. Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Metformin exactly as prescribed, tell your doctor. This medicine does not usually lower your blood sugar levels. Low blood sugar may be more likely to occur if you skip a meal, exercise heavily, or drink alcohol. It may also be more likely if you take Metformin along with certain medicines for diabetes (e. g. sulfonylureas, insulin). It is a good idea to carry a reliable source of glucose (e. g. tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals. Fever, infection, injury, or surgery may increase your risk for high or low blood sugar levels. If any of these occur, check your blood sugar closely and tell your doctor right away. Metformin may commonly cause stomach upset, indigestion, nausea, vomiting, or diarrhea at the beginning of treatment. If you develop unusual or unexpected stomach problems, or if you develop stomach problems later during treatment, contact your doctor at once. This may be a sign of lactic acidosis. Lab tests, including kidney function, fasting blood glucose, hemoglobin A1c, and blood counts, may be performed while you use Metformin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Use Metformin with caution in the elderly; they may be more sensitive to its effects. Low blood sugar levels may also be more difficult to recognize in the elderly. Metformin should not be used in children younger than 10 years old; safety and effectiveness in these children have not been confirmed. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Metformin while you are pregnant. It is not known if Metformin is found in breast milk. Do not breast-feed while taking Metformin.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; gas; headache; indigestion; nausea; stomach upset; temporary metallic taste; vomiting. Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; dizziness or lightheadedness; fast or difficult breathing; feeling of being unusually cold; fever, chills, or persistent sore throat; general feeling of being unwell; muscle pain or weakness; slow or irregular heartbeat; unusual drowsiness; unusual or persistent stomach pain or discomfort; unusual tiredness or weakness.

If you have any questions about Hydrochlorothiazide, please talk with your doctor, pharmacist, or other health care provider. Metformin is to be used only by the patient for whom it is prescribed. Do not share it with other people.

Metformin is used for treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other anti-diabetic medicines.

Use Metformin as directed by your doctor.

Take Metformin by mouth with food. Take Metformin on a regular schedule to get the most benefit from it. Taking Metformin at the same time each day will help you remember to take it. Continue taking Metformin even if you feel good. Do not miss any doses. Ask your health care provider any questions you may have about its usage.

Drug Class and Mechanism

Metformin is a biguanide antidiabetic. It works by decreasing the amount of sugar that the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.

If you miss a dose of Metformin and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Metformin between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Metformin out of the reach of children and away from pets.

Do not use Metformin if:

you are allergic to any ingredient in Metformin; you have congestive heart failure that is treated by medicine; you have a severe infection, low blood oxygen levels, kidney or liver problems, high blood ketone or acid levels (e. g. diabetic ketoacidosis), or severe dehydration; you have had a stroke or a recent heart attack, or you are in shock; you are 80 years old or older and have not had a kidney function test; you will be having surgery or certain lab procedures. Contact your doctor or health care provider right away if any of these apply to you.

Important : Dizziness may occur while you are taking Metformin. This effect may be worse if you take it with alcohol or certain medicines. Use Metformin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Follow the diet and exercise program given to you by your health care provider. Do not drink large amounts of alcohol while you use Metformin. Talk to your doctor or health care provider before you drink alcohol while you use Metformin. Tell your doctor or dentist that you take Metformin before you receive any medical or dental care, emergency care, or surgery. Be careful not to become dehydrated, especially during hot weather or while you are being active. Dehydration may increase the risk of Metformin 's side effects. Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Metformin exactly as prescribed, tell your doctor. This medicine does not usually lower your blood sugar levels. Low blood sugar may be more likely to occur if you skip a meal, exercise heavily, or drink alcohol. It may also be more likely if you take Metformin along with certain medicines for diabetes (e. g. sulfonylureas, insulin). It is a good idea to carry a reliable source of glucose (e. g. tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals. Fever, infection, injury, or surgery may increase your risk for high or low blood sugar levels. If any of these occur, check your blood sugar closely and tell your doctor right away. Metformin may commonly cause stomach upset, indigestion, nausea, vomiting, or diarrhea at the beginning of treatment. If you develop unusual or unexpected stomach problems, or if you develop stomach problems later during treatment, contact your doctor at once. This may be a sign of lactic acidosis. Lab tests, including kidney function, fasting blood glucose, hemoglobin A1c, and blood counts, may be performed while you use Metformin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Use Metformin with caution in the elderly; they may be more sensitive to its effects. Low blood sugar levels may also be more difficult to recognize in the elderly. Metformin should not be used in children younger than 10 years old; safety and effectiveness in these children have not been confirmed. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Metformin while you are pregnant. It is not known if Metformin is found in breast milk. Do not breast-feed while taking Metformin.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; gas; headache; indigestion; nausea; stomach upset; temporary metallic taste; vomiting. Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; dizziness or lightheadedness; fast or difficult breathing; feeling of being unusually cold; fever, chills, or persistent sore throat; general feeling of being unwell; muscle pain or weakness; slow or irregular heartbeat; unusual drowsiness; unusual or persistent stomach pain or discomfort; unusual tiredness or weakness.

If you have any questions about Hydrochlorothiazide, please talk with your doctor, pharmacist, or other health care provider. Metformin is to be used only by the patient for whom it is prescribed. Do not share it with other people.

Danazol - Woman S Health, Femsete

Danazol is used to treat a number of different medical problems. These include:

Endometriosis;

Fibrocystic breast disease (cysts in the breasts);

Hereditary angioedema (swelling of the different parts of the body, such as abdomen or stomach, arms, legs, throat, skin, or sexual organs.

It is very important that you use danazol only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects.

You must start taking danazol while you are having your monthly period.

In order for danazol to help you, it must be taken regularly for the full time of treatment as ordered by your doctor.

If you miss a dose of danazol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

The dose of danazol will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of danazol. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (capsules): For treatment of mild endometriosis: Adults—At first, 200 to 400 milligrams (mg), divided in two doses, for at least 3 to 6 months and up to 9 months. Your doctor may adjust your dose as needed and tolerated. Children—Use and dose must be determined by your doctor. For treatment of moderate to severe endometriosis: Adults—At first, 800 milligrams (mg) per day, divided in two doses, for at least 3 to 6 months and up to 9 months. Your doctor may adjust your dose as needed and tolerated. Children—Use and dose must be determined by your doctor. For treatment of fibrocystic breast disease: Adults—100 to 400 milligrams (mg) per day, divided in two doses. Your doctor may adjust your dose as needed and tolerated. Children—Use and dose must be determined by your doctor. For prevention of hereditary angioedema: Adults—At first, 200 milligrams (mg) two or three times a day. Your doctor may adjust your dose as needed and depending upon your condition. Children—Use and dose must be determined by your doctor.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed.

It is very important that your doctor check your progress at regular visits to make sure that danazol does not cause unwanted effects. Blood tests may be needed to check for unwanted effects.

Using danazol while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using danazol to make sure you are not pregnant. Your birth control pills may not work as well while you are using danazol. You must use an effective form of birth control (e. g. a condom, a diaphragm, spermicide) to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Using danazol may cause irregular monthly periods or absence of menstrual period. If your regular monthly period does not begin within 60 to 90 days after you stop taking danazol, check with your doctor right away.

Check with your doctor right away if you are a female and have a larger clitoris (sexual organ), deepening of your voice, or unusual hair growth after taking danazol. Your doctor may advise you to stop taking the medicine so these side effects do not get worse.

Stop using danazol and check with your doctor if you have the following symptoms while taking danazol: blurred vision; change in the ability to see colors, especially blue or yellow; headache; nausea; or vomiting.

For patients with diabetes: danazol may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, check with your doctor.

Before you have any medical tests, tell the medical doctor in charge that you are taking danazol. The results of some tests may be affected by danazol.

Danazol may rarely cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness, or other discoloration of the skin, or a severe sunburn. Check with your doctor if this occurs.

Do not take other medicines unless they have been discussed with your doctor.

Androgen like effects include weight gain, acne and seborrhea. Mild hirsutism, edema, hair loss, voice change, which may take the form of hoarseness, sore throat or of instability or deepening of pitch, may occur and may persist after cessation of therapy. Hypertrophy of the clitoris is rare.

Other possible endocrine effects include menstrual disturbances in the form of spotting, alteration of the timing of the cycle and amenorrhea. Although cyclical bleeding and ovulation usually return within 60-90 days after discontinuation of therapy with Danazol, persistent amenorrhea has occasionally been reported.

Flushing, sweating, vaginal dryness and irritation and reduction in breast size, may reflect lowering of estrogen. Nervousness and emotional lability have been reported. In the male a modest reduction in spermatogenesis may be evident during treatment. Abnormalities in semen volume, viscosity, sperm count, and motility may occur in patients receiving long-term therapy.

Hepatic dysfunction, as evidenced by reversible elevated serum enzymes and/or jaundice, has been reported in patients receiving a daily dosage of Danazol of 400 mg or more. It is recommended that patients receiving Danazol be monitored for hepatic dysfunction by laboratory tests and clinical observation. Serious hepatic toxicity including cholestatic jaundice, peliosis hepatis, and hepatic adenoma have been reported.

Danazol is used to treat a number of different medical problems. These include:

Endometriosis;

Fibrocystic breast disease (cysts in the breasts);

Hereditary angioedema (swelling of the different parts of the body, such as abdomen or stomach, arms, legs, throat, skin, or sexual organs.

It is very important that you use danazol only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects.

You must start taking danazol while you are having your monthly period.

In order for danazol to help you, it must be taken regularly for the full time of treatment as ordered by your doctor.

If you miss a dose of danazol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

The dose of danazol will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of danazol. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (capsules): For treatment of mild endometriosis: Adults—At first, 200 to 400 milligrams (mg), divided in two doses, for at least 3 to 6 months and up to 9 months. Your doctor may adjust your dose as needed and tolerated. Children—Use and dose must be determined by your doctor. For treatment of moderate to severe endometriosis: Adults—At first, 800 milligrams (mg) per day, divided in two doses, for at least 3 to 6 months and up to 9 months. Your doctor may adjust your dose as needed and tolerated. Children—Use and dose must be determined by your doctor. For treatment of fibrocystic breast disease: Adults—100 to 400 milligrams (mg) per day, divided in two doses. Your doctor may adjust your dose as needed and tolerated. Children—Use and dose must be determined by your doctor. For prevention of hereditary angioedema: Adults—At first, 200 milligrams (mg) two or three times a day. Your doctor may adjust your dose as needed and depending upon your condition. Children—Use and dose must be determined by your doctor.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed.

It is very important that your doctor check your progress at regular visits to make sure that danazol does not cause unwanted effects. Blood tests may be needed to check for unwanted effects.

Using danazol while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using danazol to make sure you are not pregnant. Your birth control pills may not work as well while you are using danazol. You must use an effective form of birth control (e. g. a condom, a diaphragm, spermicide) to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Using danazol may cause irregular monthly periods or absence of menstrual period. If your regular monthly period does not begin within 60 to 90 days after you stop taking danazol, check with your doctor right away.

Check with your doctor right away if you are a female and have a larger clitoris (sexual organ), deepening of your voice, or unusual hair growth after taking danazol. Your doctor may advise you to stop taking the medicine so these side effects do not get worse.

Stop using danazol and check with your doctor if you have the following symptoms while taking danazol: blurred vision; change in the ability to see colors, especially blue or yellow; headache; nausea; or vomiting.

For patients with diabetes: danazol may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, check with your doctor.

Before you have any medical tests, tell the medical doctor in charge that you are taking danazol. The results of some tests may be affected by danazol.

Danazol may rarely cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness, or other discoloration of the skin, or a severe sunburn. Check with your doctor if this occurs.

Do not take other medicines unless they have been discussed with your doctor.

Androgen like effects include weight gain, acne and seborrhea. Mild hirsutism, edema, hair loss, voice change, which may take the form of hoarseness, sore throat or of instability or deepening of pitch, may occur and may persist after cessation of therapy. Hypertrophy of the clitoris is rare.

Other possible endocrine effects include menstrual disturbances in the form of spotting, alteration of the timing of the cycle and amenorrhea. Although cyclical bleeding and ovulation usually return within 60-90 days after discontinuation of therapy with Danazol, persistent amenorrhea has occasionally been reported.

Flushing, sweating, vaginal dryness and irritation and reduction in breast size, may reflect lowering of estrogen. Nervousness and emotional lability have been reported. In the male a modest reduction in spermatogenesis may be evident during treatment. Abnormalities in semen volume, viscosity, sperm count, and motility may occur in patients receiving long-term therapy.

Hepatic dysfunction, as evidenced by reversible elevated serum enzymes and/or jaundice, has been reported in patients receiving a daily dosage of Danazol of 400 mg or more. It is recommended that patients receiving Danazol be monitored for hepatic dysfunction by laboratory tests and clinical observation. Serious hepatic toxicity including cholestatic jaundice, peliosis hepatis, and hepatic adenoma have been reported.

Gravimed, Gravimed

Dramamine is used for preventing and treating nausea, vomiting, and dizziness caused by motion sickness.

Use Dramamine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Dramamine may be taken with or without food. Use Dramamine exactly as directed on the package, unless instructed differently by your doctor. If you are taking Dramamine without a prescription, follow any warnings and precautions on the label. Take the first dose at least 30 minutes before activity or travel. If you miss a dose of Dramamine and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dramamine.

Use Dramamine exactly as directed by your Health Provider.

Store Dramamine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), or according to directions on the package label. Store in the original package or container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dramamine out of the reach of children and away from pets.

Some medical conditions may interact with Dramamine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant or planning to become pregnant

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, lung disease, shortness of breath, or sleep apnea

if you have a blockage of the stomach, intestine, or urinary tract; difficulty urinating; diabetes; ulcers; enlargement of the prostate; glaucoma; heart disease; irregular heartbeat; high blood pressure; porphyria; or thyroid disease

Some MEDICINES MAY INTERACT with Dramamine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Sodium oxybate (GHB) because an increase in sleep duration and a decrease in the ability to breathe are likely to occur

MAO inhibitors (eg, phenelzine) because serious side effects, such as high blood pressure or seizure, may occur

Antibiotics that may cause hearing problems (eg, gentamicin, vancomycin) because Dramamine may mask symptoms of hearing problems

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dramamine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Do NOT use Dramamine if:

you are allergic to any ingredient in Dramamine or other similar medicines

you are taking sodium oxybate (GHB)

you are currently taking or have taken a monoamine oxidase (MAO) inhibitor (eg, phenelzine) in the past 14 days

you are breast-feeding

Contact your doctor or health care provider right away if any of these apply to you.

Dramamine may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Dramamine. Using Dramamine alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Dramamine. Dramamine will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants. Dramamine may cause dizziness. Alcohol, hot weather, exercise, and fever can increase this effect. To prevent it, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness. Do not exceed the recommended dose or use Dramamine more frequently or for longer than prescribed without first checking with your doctor. Do not become overheated in hot weather or during exercise or other activities since heatstroke may occur. Dramamine may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Dramamine. Use a sunscreen or protective clothing if you must be outside for a prolonged period. Do not use Dramamine with any medicine that contains diphenhydramine. Before you begin taking any new prescription or nonprescription medicine, including one used on the skin, read the ingredients to see if it also contains diphenhydramine or another similar medicine (eg, antihistamine). If it does, or if you are uncertain if it does, contact your doctor or pharmacist. Use Dramamine with caution in the ELDERLY because they may be more sensitive to its effects, especially dizziness, sedation, and lightheadedness upon standing. Safe use and instructions for use in CHILDREN differs according to the brand used. Talk to your doctor or pharmacist if you have any questions about the brand you are using. Use of Dramamine is not recommended in CHILDREN younger than 2 years of age without first talking with the child's doctor. Safety and effectiveness in this age group have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Dramamine during pregnancy. Dramamine is excreted in breast milk. Do not breast-feed while taking Dramamine.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth, throat, and nose; thickening of mucus in nose or throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; convulsions; decreased alertness; difficulty urinating; excessive excitability; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; mental or mood changes; pounding in the chest; seizures; tremor; unusual bruising or bleeding; wheezing; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Dramamine is used for preventing and treating nausea, vomiting, and dizziness caused by motion sickness.

Use Dramamine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Dramamine may be taken with or without food. Use Dramamine exactly as directed on the package, unless instructed differently by your doctor. If you are taking Dramamine without a prescription, follow any warnings and precautions on the label. Take the first dose at least 30 minutes before activity or travel. If you miss a dose of Dramamine and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dramamine.

Use Dramamine exactly as directed by your Health Provider.

Store Dramamine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), or according to directions on the package label. Store in the original package or container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dramamine out of the reach of children and away from pets.

Some medical conditions may interact with Dramamine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant or planning to become pregnant

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, lung disease, shortness of breath, or sleep apnea

if you have a blockage of the stomach, intestine, or urinary tract; difficulty urinating; diabetes; ulcers; enlargement of the prostate; glaucoma; heart disease; irregular heartbeat; high blood pressure; porphyria; or thyroid disease

Some MEDICINES MAY INTERACT with Dramamine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Sodium oxybate (GHB) because an increase in sleep duration and a decrease in the ability to breathe are likely to occur

MAO inhibitors (eg, phenelzine) because serious side effects, such as high blood pressure or seizure, may occur

Antibiotics that may cause hearing problems (eg, gentamicin, vancomycin) because Dramamine may mask symptoms of hearing problems

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dramamine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Do NOT use Dramamine if:

you are allergic to any ingredient in Dramamine or other similar medicines

you are taking sodium oxybate (GHB)

you are currently taking or have taken a monoamine oxidase (MAO) inhibitor (eg, phenelzine) in the past 14 days

you are breast-feeding

Contact your doctor or health care provider right away if any of these apply to you.

Dramamine may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Dramamine. Using Dramamine alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Dramamine. Dramamine will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants. Dramamine may cause dizziness. Alcohol, hot weather, exercise, and fever can increase this effect. To prevent it, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness. Do not exceed the recommended dose or use Dramamine more frequently or for longer than prescribed without first checking with your doctor. Do not become overheated in hot weather or during exercise or other activities since heatstroke may occur. Dramamine may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Dramamine. Use a sunscreen or protective clothing if you must be outside for a prolonged period. Do not use Dramamine with any medicine that contains diphenhydramine. Before you begin taking any new prescription or nonprescription medicine, including one used on the skin, read the ingredients to see if it also contains diphenhydramine or another similar medicine (eg, antihistamine). If it does, or if you are uncertain if it does, contact your doctor or pharmacist. Use Dramamine with caution in the ELDERLY because they may be more sensitive to its effects, especially dizziness, sedation, and lightheadedness upon standing. Safe use and instructions for use in CHILDREN differs according to the brand used. Talk to your doctor or pharmacist if you have any questions about the brand you are using. Use of Dramamine is not recommended in CHILDREN younger than 2 years of age without first talking with the child's doctor. Safety and effectiveness in this age group have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Dramamine during pregnancy. Dramamine is excreted in breast milk. Do not breast-feed while taking Dramamine.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth, throat, and nose; thickening of mucus in nose or throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; convulsions; decreased alertness; difficulty urinating; excessive excitability; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; mental or mood changes; pounding in the chest; seizures; tremor; unusual bruising or bleeding; wheezing; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Dramamine is used for preventing and treating nausea, vomiting, and dizziness caused by motion sickness.

Use Dramamine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Dramamine may be taken with or without food. Use Dramamine exactly as directed on the package, unless instructed differently by your doctor. If you are taking Dramamine without a prescription, follow any warnings and precautions on the label. Take the first dose at least 30 minutes before activity or travel. If you miss a dose of Dramamine and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dramamine.

Use Dramamine exactly as directed by your Health Provider.

Store Dramamine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), or according to directions on the package label. Store in the original package or container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dramamine out of the reach of children and away from pets.

Some medical conditions may interact with Dramamine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant or planning to become pregnant

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, lung disease, shortness of breath, or sleep apnea

if you have a blockage of the stomach, intestine, or urinary tract; difficulty urinating; diabetes; ulcers; enlargement of the prostate; glaucoma; heart disease; irregular heartbeat; high blood pressure; porphyria; or thyroid disease

Some MEDICINES MAY INTERACT with Dramamine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Sodium oxybate (GHB) because an increase in sleep duration and a decrease in the ability to breathe are likely to occur

MAO inhibitors (eg, phenelzine) because serious side effects, such as high blood pressure or seizure, may occur

Antibiotics that may cause hearing problems (eg, gentamicin, vancomycin) because Dramamine may mask symptoms of hearing problems

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dramamine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Do NOT use Dramamine if:

you are allergic to any ingredient in Dramamine or other similar medicines

you are taking sodium oxybate (GHB)

you are currently taking or have taken a monoamine oxidase (MAO) inhibitor (eg, phenelzine) in the past 14 days

you are breast-feeding

Contact your doctor or health care provider right away if any of these apply to you.

Dramamine may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Dramamine. Using Dramamine alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Dramamine. Dramamine will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants. Dramamine may cause dizziness. Alcohol, hot weather, exercise, and fever can increase this effect. To prevent it, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness. Do not exceed the recommended dose or use Dramamine more frequently or for longer than prescribed without first checking with your doctor. Do not become overheated in hot weather or during exercise or other activities since heatstroke may occur. Dramamine may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Dramamine. Use a sunscreen or protective clothing if you must be outside for a prolonged period. Do not use Dramamine with any medicine that contains diphenhydramine. Before you begin taking any new prescription or nonprescription medicine, including one used on the skin, read the ingredients to see if it also contains diphenhydramine or another similar medicine (eg, antihistamine). If it does, or if you are uncertain if it does, contact your doctor or pharmacist. Use Dramamine with caution in the ELDERLY because they may be more sensitive to its effects, especially dizziness, sedation, and lightheadedness upon standing. Safe use and instructions for use in CHILDREN differs according to the brand used. Talk to your doctor or pharmacist if you have any questions about the brand you are using. Use of Dramamine is not recommended in CHILDREN younger than 2 years of age without first talking with the child's doctor. Safety and effectiveness in this age group have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Dramamine during pregnancy. Dramamine is excreted in breast milk. Do not breast-feed while taking Dramamine.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth, throat, and nose; thickening of mucus in nose or throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; convulsions; decreased alertness; difficulty urinating; excessive excitability; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; mental or mood changes; pounding in the chest; seizures; tremor; unusual bruising or bleeding; wheezing; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Buy Anxiety - E-Zentius (Brand Name Lexapro) Online - Order Escitalopram - Purchase Anxiety - E-Zent

What is this medicine?

ESCITALOPRAM is used to treat depression and certain types of anxiety.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: bipolar disorder or a family history of bipolar disorder diabetes heart disease kidney or liver disease receiving electroconvulsive therapy seizures (convulsions) suicidal thoughts, plans, or attempt by you or a family member an unusual or allergic reaction to escitalopram, the related drug citalopram, other medicines, foods, dyes, or preservatives pregnant or trying to become pregnant breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine, contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following: certain diet drugs like dexfenfluramine, fenfluramine, phentermine, sibutramine cisapride citalopram medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl nefazodone phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine procarbazine St. John's Wort venlafaxine

This medicine may also interact with the following: amphetamine or dextroamphetamine aspirin and aspirin-like drugs carbamazepine cimetidine ketoconazole linezolid medicines for depression, anxiety, or psychotic disturbances medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin medicines that treat HIV infection or AIDS medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan medicines used to treat tuberculosis like isoniazid, rifabutin, rifampin, rifapentine metoclopramide NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen pentazocine tryptophan

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Continue taking your tablets even if you do not feel better right away. It can take 1 to 2 weeks or longer before you start to feel the effects of this medicine.

Patients and their families should watch out for worsening depression or thoughts of suicide. Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

If you have been taking this medicine regularly for some time, do not stop taking it suddenly. You must gradually reduce the dose, or your symptoms may get worse. Ask your doctor or health care professional for advice.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible are: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue confusion feeling faint or lightheaded, falls fast talking and excited feelings or actions that are out of control hallucination, loss of contact with reality seizures suicidal thoughts or other mood changes unusual bleeding or bruising

Side effects that do not require medical attention usually (report to your doctor or health care professional if they continue or are bothersome): blurred vision changes in appetite change in sex drive or performance headache increased sweating nausea

This list may not describe all possible side effects.

Where should I keep my medicine?

Keep out of reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What is this medicine?

ESCITALOPRAM is used to treat depression and certain types of anxiety.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: bipolar disorder or a family history of bipolar disorder diabetes heart disease kidney or liver disease receiving electroconvulsive therapy seizures (convulsions) suicidal thoughts, plans, or attempt by you or a family member an unusual or allergic reaction to escitalopram, the related drug citalopram, other medicines, foods, dyes, or preservatives pregnant or trying to become pregnant breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine, contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following: certain diet drugs like dexfenfluramine, fenfluramine, phentermine, sibutramine cisapride citalopram medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl nefazodone phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine procarbazine St. John's Wort venlafaxine

This medicine may also interact with the following: amphetamine or dextroamphetamine aspirin and aspirin-like drugs carbamazepine cimetidine ketoconazole linezolid medicines for depression, anxiety, or psychotic disturbances medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin medicines that treat HIV infection or AIDS medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan medicines used to treat tuberculosis like isoniazid, rifabutin, rifampin, rifapentine metoclopramide NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen pentazocine tryptophan

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Continue taking your tablets even if you do not feel better right away. It can take 1 to 2 weeks or longer before you start to feel the effects of this medicine.

Patients and their families should watch out for worsening depression or thoughts of suicide. Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

If you have been taking this medicine regularly for some time, do not stop taking it suddenly. You must gradually reduce the dose, or your symptoms may get worse. Ask your doctor or health care professional for advice.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible are: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue confusion feeling faint or lightheaded, falls fast talking and excited feelings or actions that are out of control hallucination, loss of contact with reality seizures suicidal thoughts or other mood changes unusual bleeding or bruising

Side effects that do not require medical attention usually (report to your doctor or health care professional if they continue or are bothersome): blurred vision changes in appetite change in sex drive or performance headache increased sweating nausea

This list may not describe all possible side effects.

Where should I keep my medicine?

Keep out of reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Ketoconazol, Nizoral, Fungium, Ketoisdin, Fungarest, Eumicel, Orifungal, Quadion, Lindox, Chemicon

Informacion: Ketoconazol (Oral) Medicamentos ?QUE ES?

El ketoconazol es un antifungico utilizado en el tratamiento de infecciones producidas por hongos y levaduras, que pueden ocurrir en diferentes partes del cuerpo, tales como infecciones de la vagina persistentes, infecciones de la piel, pelo, estomago, intestino y otros organos.

El ketoconazol puede tambien prescribirse para prevenir infecciones por hongos en personas cuyas defensas naturales estan seriamente danadas.

Si algo de la informacion en este folleto le causa preocupacion especial o si desea mas informacion acerca de su medicamento y su uso, consulte con su medico, enfermera o farmaceutico. Recuerde, mantenga este y todos los demas medicamentos fuera del alcance de los ninos y nunca comparta sus medicamentos con otras personas. ANTES DE USAR

Digale a su medico, enfermera y farmaceutico si usted.

es alergico a cualquier otro medicamento, ya sea recetado o no; esta embarazada o piensa quedar embarazada mientras este usando este medicamento; esta dando el pecho; esta usando cualquier otro medicamento recetado o no; esta tomando astemizol, cisaprida, terfenadina o medicamentos que contienen terfenadina; tiene cualquier otro problema medico, especialmente aclorhidria (falta de acido en el estomago), abuso de alcohol (o historial de), hipoclorhidria (reduccion en la cantidad de acido en el estomago) o enfermedad del higado. USO APROPIADO

Este medicamento se debe tomar con una comida o un bocadillo.

Si tiene aclorhidria o hipoclorhidria, puede que su medico quiera que usted tome su medicamento con una bebida acidica, tal como cola o soda, o mezclado en una solucion especial de acido clorhidrico debil. Asegurese de seguir las instrucciones de su medico cuidadosamente.

Para ayudar a curar su infeccion completamente, es muy importante que siga tomando este medicamento por el plazo completo del tratamiento aunque sus sintomas empiecen a desaparecer o se empiece a sentir mejor despues de unos dias.

Este medicamento funciona mejor cuando hay una cantidad constante en la sangre o la orina. Para ayudar a mantener constante la cantidad, no deje pasar ninguna de las dosis. Ademas, es mejor tomar cada dosis a la misma hora todos los dias. Si necesita ayuda para planificar el mejor momento de usar su medicamento, consulte con su medico, enfermera o farmaceutico.

Si se le pasa una dosis de este medicamento, tomela lo antes posible. Esto ayudara a mantener una cantidad constante de medicamento en la sangre o en la orina. Sin embargo, si es casi hora para su proxima dosis, deje pasar la dosis olvidada y vuelva a su horario regular de dosificacion. No use doble cantidad.

Para guardar este medicamento:

Guarde fuera del alcance de los ninos. Alejado del calor y la luz directa. No lo guarde las capsulas o tabletas de este medicamento en el bano, cerca del lavaplatos en la cocina o en otros sitios humedos. El calor o la humedad pueden deteriorar el medicamento. No conserve medicamentos cuya fecha haya expirado o que no necesita mas. Asegurese de desechar sus medicamentos en un sitio fuera del alcance de los ninos. PRECAUCIONES

Este medicamento no se debe tomar con astemizol (Hismanal), cisaprida (Propulsid), terfenadina (Seldane) o medicamentos que contienen terfenadina (Seldane-D). El hacerlo puede aumentar el riesgo de efectos secundarios serios que afectan el corazon y podria poner en peligro la vida.

Es importante que su medico revise su progreso mediante visitas regulares. Esto permitira que su medico revise si hay algun efecto no deseado.

Si sus sintomas no mejoran en unas semanas, o si empeoran, consulte con su medico.

Si esta tomando antiacidos, cimetidina (Tagamet), famotidina (/ /Pepcid), nizatidina (Axid), omeprazol (Prilosec) o ranitidina (Zantac) mientras esta tomando ketoconazol, tomelos al menos 2 horas despues de tomar el ketoconazol. Si toma estos medicamentos a la misma vez que toma ketoconazol, impediran que el ketoconazol funcione correctamente.

Puede que sea mas probable que ocurran problemas del higado si toma bebidas alcoholicas mientras esta tomando este medicamento. Las bebidas alcoholicas tambien pueden causar dolor de estomago, nauseas, vomitos, dolor de cabeza o sofocos o enrojecimiento de la cara. Otras preparaciones que contienen alcohol (por ejemplo, elixires, jarabes para la tos o tonicos) tambien pueden causar problemas. Estos problemas pueden ocurrir por al menos un dia despues de dejar de tomar el ketoconazol. Por lo tanto, no debe tomar bebidas alcoholicas mientras este tomando ketoconazol y por al menos un dia despues de dejar de tomarlo.

Este medicamento puede causar que sus ojos se vuelvan mas sensibles a la luz que lo normal. El usar lentes de sol y el evitar demasiada exposicion a la luz brillante puede ayudar a disminuir la molestia.

Este medicamento tambien puede causar que algunas personas tengan mareos, sueno o que esten menos alertas de lo normal.

Asegurese de saber como reacciona a este medicamento antes de manejar, usar maquinaria o hacer otras tareas que requieran que est EFECTOS LATERALES

Efectos secundarios que deben ser informados a su medico inmediatamente

Menos comunes -- Fiebre o escalofrios; salpullido o comezon

Raros -- Orina oscura o color ambar; perdida del apetito; heces palidas; dolor de estomago; cansancio o debilidad inusual; ojos o piel amarillos

Efectos secundarios que usualmente no requieren atencion medica

Estos posibles efectos secundarios pueden desaparecer durante el tratamiento; sin embargo, si continuan o son molestos, consulte con su medico, enfermera o farmaceutico.

Menos comunes -- Estrenimiento; diarrea; mareos; sueno; dolor de cabeza; nauseas; vomitos

Raros -- Capacidad sexual reducida o senos agrandados en los varones; aumento de la sensibilidad de los ojos a la luz; irregularidades menstruales

Otros efectos secundarios no listados arriba tambien pueden ocurrir en algunos pacientes. Si nota cualquier otro efecto, consulte con su medico, enfermera o farmaceutico.

El ketoconazol es un antimicotico derivado del imidazol. Es ademas un potente inhibidor no selectivo de la sintesis de esteroides suprarrenales y gonadales.(1) CLASIFICACION

Es un antimicotico bencimidazolico.(1) FARMACOCINETICA

Por via oral el ketoconazol tiene una absorcion variable entre cada persona ya que necesita un medio acido para que se disuelva el farmaco. Su vida media aumenta con la dosis y puede ser de 7 a 8 horas si la dosis ha sido de 800 mg. Se metaboliza en forma extensa y sus productos inactivos aparecen en las heces. Sus concentraciones en orina son muy pequenas.(2) FARMACODINAMIA

Este compuesto inhibe la fragmentacion de las cadenas colaterales del colesterol y a las enzimas P450c17, C17, 20-liasa, 3?-hidroxiesteroide deshidrogenasa y P450c10, que se requieren para la sintesis de glucocorticoides.(1)

En los hongos inhibe la formacion de esteroles necesarios para la estructuracion de la membrana celular y por esto su efecto antimicotico.

La sensibilidad de las enzimas P450 a este compuesto en los tejidos de mamiferos es mucho menor que las enzimas micoticas de modo que los efectos inhibidores solo se observan en dosis altas, esto se compensa con un incremento en la produccion de ACTH, y esto aumenta los 17-desoxiesteroides como la progesterona y aldosterona, y suprime la actividad de la renina plasmatica.(1) INDICACIONES

El ketoconazol se lo usa tanto en forma topica como en forma sistemica. Por via topica es eficaz en las fitodermatosis o tinas de piel, y sus anexos (unas, pelos) en la candidiasis mucocutanea cronica, vulvovaginitis por Candida, candidiasis de boca y esofago y en la forma de shampoo se lo usa para la caspa ya que se le ha atribuido al hongo Pitirosporum ovale la etiologia de esta dermatosis del cuero cabelludo.(2) [?]

Por via sistemica se usa en el tratamiento de la blastomicosis, coccidiodomicosis, paracoccidioidomicosis e histoplasmosis.

Ademas de los usos como antimicotico, a este farmaco tambien se le han encontrado nuevos usos: como sinergico en la terapia contra la enfermedad de Chagas [?], y en transplante de corazon. [?] SITUACIONES ESPECIALES

Este farmaco tiene una categoria C para su uso en el embarazo.(3) CONTRAINDICACIONES

Ketoconazol esta contraindicado en personas que muestren hipersensibilidad al farmaco o a los excipientes de la composicion.(3) EFECTOS SECUNDARIOS

El uso topico de ketoconazol ha reportado efectos como irritacion severa, prurito y punzadas. El ketoconazol en shampoo si es usado muy a menudo presenta reacciones como incremento en la caida y alteraciones en la textura normal del cabello, pustulas en el cuero cabelludo, leve sequedad de la piel y comezon.(3)

Hepatotoxicidad, primaria del tipo hepatocelular, ha sido asociado con el uso de tabletas de ketoconazol, incluyendo raras fatalidades. El reporte de incidencia de hepatotoxicidad ha sido alrededor de 1:10 000 pacientes expuestos, pero esto probablemente represente algun grado de subregistro. La duracion media de la terapia con ketoconazol en pacientes que desarrollaron hepatotoxicidad sintomatica fue alrededor de 28 dias.

El ketoconazol por via oral ha presentado en raros casos anafilaxia luego de la primera dosis, en ocasiones se han reportado tambien reacciones de hipersensibilidad como urticaria. Otros sintomas secundarios son: nausea o vomito, dolor abdominal, prurito, cefaleas, pereza, somnolencia, fiebre y escalofrios, fotofobia, diarrea ginecomastia, impotencia, trombocitopenia, leucopenia y anemia hemolitica. Su uso prolongado disminuye los niveles de testosterona, y puede ocurrir oligospermia.(3)

En alguna experiencia con ketoconazol se reportaron alopecia, parestesia y signos de aumento de presion intracareal, ademas papiledema.(3)

Se presentaron en algunas personas disturbios neuropsiquiatricos incluyendose tendencias suicidas y depresion severa.(3) PRECAUCIONES

En caso de presentarse alguna reaccion dermica se debe descontinuar el uso del medicamento. El ketoconazol requiere un medio acido para su absorcion, los pacientes con aclorhidria tienen mala absorcion de ketoconazol.(3) INTERACCIONES

En tabletas el ketoconazol inhibe el metabolismo de la terfenadina y el astemizol dando como resultado un incremento de la concentracion plasmatica de estos farmacos provocando en el paciente un aumento del intervalo QT.(3)

El uso concomitante de ketoconazol con ciclosporina, tacrolimus y metilprednisolona aumenta los niveles plasmaticos de estos tres farmacos, de igual manera ocurre con midazolam y triazolam.(3)

Se han reportado raros casos del efecto disulfiran en el uso de ketoconazol concomitante con alcohol.(3) SOBREDOSIS, TOXICIDAD Y TRATAMIENTO

En casos de ingestion de shampoo o una sobre dosis de ketoconazol la medida a tomarse es hacer un lavado gastrico con bicarbonato de sodio.(3) CONSERVACION

Se debe conservar a una temperatura entre 15 °C y 25 °C.(3) POSOLOGIA

Crema: en caso de candidiasis cutanea, tinea corporis, tinea cruris y tinea versicolor, se debe aplicar en la zona afectada una vez al dia por dos semanas. En casos de dermatitis seborreica se debe aplicar 2 veces por dia durante 4 semanas.(3)

Shampoo: aplicar 2 veces por semana durante 4 semanas.(3)

Adultos: 200 mg una vez al dia, en infecciones severas se puede incrementar la dosis a 400 mg una vez al dia.(3) Ninos: ninos sobre los 2 anos de edad una sola dosis de 3,3 mg/kg a 6,6 mg/kg. No se han hecho estudios de ketoconazol en ninos menores de los 2 anos de edad.(3)

IESS: Si pertenece

MSP: Si pertenece

Los antifungicos disponibles para el tratamiento de las micosis, actuan esencialmente sobre el ergosterol de la membrana del hongo (anfotericina B)[5], inhibiendo su sintesis (azoles) y sobre el RNA y DNA fungicos. La pared fungica esta formada esencialmente por manoproteinas o galactomanano, glucano y quitina, lo que constituye un buen objetivo farmacologico, dado que no esta presente en la celula humana. Se han probado combinaciones entre ellos, sobre todo azoles y anfotericina B, aunque pocos ensayos clinicos han demostrado algun beneficio [6].

Maria Bernal Morillo y Almudena Sanchez Lopez

Informacion: Ketoconazol (Oral) Medicamentos ?QUE ES?

El ketoconazol es un antifungico utilizado en el tratamiento de infecciones producidas por hongos y levaduras, que pueden ocurrir en diferentes partes del cuerpo, tales como infecciones de la vagina persistentes, infecciones de la piel, pelo, estomago, intestino y otros organos.

El ketoconazol puede tambien prescribirse para prevenir infecciones por hongos en personas cuyas defensas naturales estan seriamente danadas.

Si algo de la informacion en este folleto le causa preocupacion especial o si desea mas informacion acerca de su medicamento y su uso, consulte con su medico, enfermera o farmaceutico. Recuerde, mantenga este y todos los demas medicamentos fuera del alcance de los ninos y nunca comparta sus medicamentos con otras personas. ANTES DE USAR

Digale a su medico, enfermera y farmaceutico si usted.

es alergico a cualquier otro medicamento, ya sea recetado o no; esta embarazada o piensa quedar embarazada mientras este usando este medicamento; esta dando el pecho; esta usando cualquier otro medicamento recetado o no; esta tomando astemizol, cisaprida, terfenadina o medicamentos que contienen terfenadina; tiene cualquier otro problema medico, especialmente aclorhidria (falta de acido en el estomago), abuso de alcohol (o historial de), hipoclorhidria (reduccion en la cantidad de acido en el estomago) o enfermedad del higado. USO APROPIADO

Este medicamento se debe tomar con una comida o un bocadillo.

Si tiene aclorhidria o hipoclorhidria, puede que su medico quiera que usted tome su medicamento con una bebida acidica, tal como cola o soda, o mezclado en una solucion especial de acido clorhidrico debil. Asegurese de seguir las instrucciones de su medico cuidadosamente.

Para ayudar a curar su infeccion completamente, es muy importante que siga tomando este medicamento por el plazo completo del tratamiento aunque sus sintomas empiecen a desaparecer o se empiece a sentir mejor despues de unos dias.

Este medicamento funciona mejor cuando hay una cantidad constante en la sangre o la orina. Para ayudar a mantener constante la cantidad, no deje pasar ninguna de las dosis. Ademas, es mejor tomar cada dosis a la misma hora todos los dias. Si necesita ayuda para planificar el mejor momento de usar su medicamento, consulte con su medico, enfermera o farmaceutico.

Si se le pasa una dosis de este medicamento, tomela lo antes posible. Esto ayudara a mantener una cantidad constante de medicamento en la sangre o en la orina. Sin embargo, si es casi hora para su proxima dosis, deje pasar la dosis olvidada y vuelva a su horario regular de dosificacion. No use doble cantidad.

Para guardar este medicamento:

Guarde fuera del alcance de los ninos. Alejado del calor y la luz directa. No lo guarde las capsulas o tabletas de este medicamento en el bano, cerca del lavaplatos en la cocina o en otros sitios humedos. El calor o la humedad pueden deteriorar el medicamento. No conserve medicamentos cuya fecha haya expirado o que no necesita mas. Asegurese de desechar sus medicamentos en un sitio fuera del alcance de los ninos. PRECAUCIONES

Este medicamento no se debe tomar con astemizol (Hismanal), cisaprida (Propulsid), terfenadina (Seldane) o medicamentos que contienen terfenadina (Seldane-D). El hacerlo puede aumentar el riesgo de efectos secundarios serios que afectan el corazon y podria poner en peligro la vida.

Es importante que su medico revise su progreso mediante visitas regulares. Esto permitira que su medico revise si hay algun efecto no deseado.

Si sus sintomas no mejoran en unas semanas, o si empeoran, consulte con su medico.

Si esta tomando antiacidos, cimetidina (Tagamet), famotidina (/ /Pepcid), nizatidina (Axid), omeprazol (Prilosec) o ranitidina (Zantac) mientras esta tomando ketoconazol, tomelos al menos 2 horas despues de tomar el ketoconazol. Si toma estos medicamentos a la misma vez que toma ketoconazol, impediran que el ketoconazol funcione correctamente.

Puede que sea mas probable que ocurran problemas del higado si toma bebidas alcoholicas mientras esta tomando este medicamento. Las bebidas alcoholicas tambien pueden causar dolor de estomago, nauseas, vomitos, dolor de cabeza o sofocos o enrojecimiento de la cara. Otras preparaciones que contienen alcohol (por ejemplo, elixires, jarabes para la tos o tonicos) tambien pueden causar problemas. Estos problemas pueden ocurrir por al menos un dia despues de dejar de tomar el ketoconazol. Por lo tanto, no debe tomar bebidas alcoholicas mientras este tomando ketoconazol y por al menos un dia despues de dejar de tomarlo.

Este medicamento puede causar que sus ojos se vuelvan mas sensibles a la luz que lo normal. El usar lentes de sol y el evitar demasiada exposicion a la luz brillante puede ayudar a disminuir la molestia.

Este medicamento tambien puede causar que algunas personas tengan mareos, sueno o que esten menos alertas de lo normal.

Asegurese de saber como reacciona a este medicamento antes de manejar, usar maquinaria o hacer otras tareas que requieran que est EFECTOS LATERALES

Efectos secundarios que deben ser informados a su medico inmediatamente

Menos comunes -- Fiebre o escalofrios; salpullido o comezon

Raros -- Orina oscura o color ambar; perdida del apetito; heces palidas; dolor de estomago; cansancio o debilidad inusual; ojos o piel amarillos

Efectos secundarios que usualmente no requieren atencion medica

Estos posibles efectos secundarios pueden desaparecer durante el tratamiento; sin embargo, si continuan o son molestos, consulte con su medico, enfermera o farmaceutico.

Menos comunes -- Estrenimiento; diarrea; mareos; sueno; dolor de cabeza; nauseas; vomitos

Raros -- Capacidad sexual reducida o senos agrandados en los varones; aumento de la sensibilidad de los ojos a la luz; irregularidades menstruales

Otros efectos secundarios no listados arriba tambien pueden ocurrir en algunos pacientes. Si nota cualquier otro efecto, consulte con su medico, enfermera o farmaceutico.

El ketoconazol es un antimicotico derivado del imidazol. Es ademas un potente inhibidor no selectivo de la sintesis de esteroides suprarrenales y gonadales.(1) CLASIFICACION

Es un antimicotico bencimidazolico.(1) FARMACOCINETICA

Por via oral el ketoconazol tiene una absorcion variable entre cada persona ya que necesita un medio acido para que se disuelva el farmaco. Su vida media aumenta con la dosis y puede ser de 7 a 8 horas si la dosis ha sido de 800 mg. Se metaboliza en forma extensa y sus productos inactivos aparecen en las heces. Sus concentraciones en orina son muy pequenas.(2) FARMACODINAMIA

Este compuesto inhibe la fragmentacion de las cadenas colaterales del colesterol y a las enzimas P450c17, C17, 20-liasa, 3?-hidroxiesteroide deshidrogenasa y P450c10, que se requieren para la sintesis de glucocorticoides.(1)

En los hongos inhibe la formacion de esteroles necesarios para la estructuracion de la membrana celular y por esto su efecto antimicotico.

La sensibilidad de las enzimas P450 a este compuesto en los tejidos de mamiferos es mucho menor que las enzimas micoticas de modo que los efectos inhibidores solo se observan en dosis altas, esto se compensa con un incremento en la produccion de ACTH, y esto aumenta los 17-desoxiesteroides como la progesterona y aldosterona, y suprime la actividad de la renina plasmatica.(1) INDICACIONES

El ketoconazol se lo usa tanto en forma topica como en forma sistemica. Por via topica es eficaz en las fitodermatosis o tinas de piel, y sus anexos (unas, pelos) en la candidiasis mucocutanea cronica, vulvovaginitis por Candida, candidiasis de boca y esofago y en la forma de shampoo se lo usa para la caspa ya que se le ha atribuido al hongo Pitirosporum ovale la etiologia de esta dermatosis del cuero cabelludo.(2) [?]

Por via sistemica se usa en el tratamiento de la blastomicosis, coccidiodomicosis, paracoccidioidomicosis e histoplasmosis.

Ademas de los usos como antimicotico, a este farmaco tambien se le han encontrado nuevos usos: como sinergico en la terapia contra la enfermedad de Chagas [?], y en transplante de corazon. [?] SITUACIONES ESPECIALES

Este farmaco tiene una categoria C para su uso en el embarazo.(3) CONTRAINDICACIONES

Ketoconazol esta contraindicado en personas que muestren hipersensibilidad al farmaco o a los excipientes de la composicion.(3) EFECTOS SECUNDARIOS

El uso topico de ketoconazol ha reportado efectos como irritacion severa, prurito y punzadas. El ketoconazol en shampoo si es usado muy a menudo presenta reacciones como incremento en la caida y alteraciones en la textura normal del cabello, pustulas en el cuero cabelludo, leve sequedad de la piel y comezon.(3)

Hepatotoxicidad, primaria del tipo hepatocelular, ha sido asociado con el uso de tabletas de ketoconazol, incluyendo raras fatalidades. El reporte de incidencia de hepatotoxicidad ha sido alrededor de 1:10 000 pacientes expuestos, pero esto probablemente represente algun grado de subregistro. La duracion media de la terapia con ketoconazol en pacientes que desarrollaron hepatotoxicidad sintomatica fue alrededor de 28 dias.

El ketoconazol por via oral ha presentado en raros casos anafilaxia luego de la primera dosis, en ocasiones se han reportado tambien reacciones de hipersensibilidad como urticaria. Otros sintomas secundarios son: nausea o vomito, dolor abdominal, prurito, cefaleas, pereza, somnolencia, fiebre y escalofrios, fotofobia, diarrea ginecomastia, impotencia, trombocitopenia, leucopenia y anemia hemolitica. Su uso prolongado disminuye los niveles de testosterona, y puede ocurrir oligospermia.(3)

En alguna experiencia con ketoconazol se reportaron alopecia, parestesia y signos de aumento de presion intracareal, ademas papiledema.(3)

Se presentaron en algunas personas disturbios neuropsiquiatricos incluyendose tendencias suicidas y depresion severa.(3) PRECAUCIONES

En caso de presentarse alguna reaccion dermica se debe descontinuar el uso del medicamento. El ketoconazol requiere un medio acido para su absorcion, los pacientes con aclorhidria tienen mala absorcion de ketoconazol.(3) INTERACCIONES

En tabletas el ketoconazol inhibe el metabolismo de la terfenadina y el astemizol dando como resultado un incremento de la concentracion plasmatica de estos farmacos provocando en el paciente un aumento del intervalo QT.(3)

El uso concomitante de ketoconazol con ciclosporina, tacrolimus y metilprednisolona aumenta los niveles plasmaticos de estos tres farmacos, de igual manera ocurre con midazolam y triazolam.(3)

Se han reportado raros casos del efecto disulfiran en el uso de ketoconazol concomitante con alcohol.(3) SOBREDOSIS, TOXICIDAD Y TRATAMIENTO

En casos de ingestion de shampoo o una sobre dosis de ketoconazol la medida a tomarse es hacer un lavado gastrico con bicarbonato de sodio.(3) CONSERVACION

Se debe conservar a una temperatura entre 15 °C y 25 °C.(3) POSOLOGIA

Crema: en caso de candidiasis cutanea, tinea corporis, tinea cruris y tinea versicolor, se debe aplicar en la zona afectada una vez al dia por dos semanas. En casos de dermatitis seborreica se debe aplicar 2 veces por dia durante 4 semanas.(3)

Shampoo: aplicar 2 veces por semana durante 4 semanas.(3)

Adultos: 200 mg una vez al dia, en infecciones severas se puede incrementar la dosis a 400 mg una vez al dia.(3) Ninos: ninos sobre los 2 anos de edad una sola dosis de 3,3 mg/kg a 6,6 mg/kg. No se han hecho estudios de ketoconazol en ninos menores de los 2 anos de edad.(3)

IESS: Si pertenece

MSP: Si pertenece

Los antifungicos disponibles para el tratamiento de las micosis, actuan esencialmente sobre el ergosterol de la membrana del hongo (anfotericina B)[5], inhibiendo su sintesis (azoles) y sobre el RNA y DNA fungicos. La pared fungica esta formada esencialmente por manoproteinas o galactomanano, glucano y quitina, lo que constituye un buen objetivo farmacologico, dado que no esta presente en la celula humana. Se han probado combinaciones entre ellos, sobre todo azoles y anfotericina B, aunque pocos ensayos clinicos han demostrado algun beneficio [6].

Maria Bernal Morillo y Almudena Sanchez Lopez

Buy Trigynon Online - Self Healing Centre, Trigynon

Trigynon

Medication guide about Trigynon (Levonorgestrel + Ethinyl Estradiol)

Brand name: Trigynon Generic name: Levonorgestrel + Ethinyl Estradiol

What is the most important information I should know about Trigynon? Take your pill at the same time every day. Each dose should come no more than 24 hours after the last dose. Avoid smoking cigarettes while taking Trigynon. Smoking greatly increases the risk of having a heart attack, stroke, or blood clot. Use another form of birth control if you miss several doses (see the package insert) or if you are taking drugs that decrease the effectiveness of Trigynon (see the section of this leaflet titled “What other drugs will affect my Trigynon?”).

What are Trigynon? Trigynon contain a combination of hormones that is used to prevent ovulation (the release of an egg from an ovary). The pills contain a form of estrogen and a form of progesterone, which are both female hormones involved in conception. Trigynon also have other effects that inhibit pregnancy. They cause the cervical mucous to thicken, which makes it harder for sperm to move toward the uterus, and they prevent the attachment of an egg to the uterus. Trigynon are used to prevent pregnancy. Trigynon may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking Trigynon? Before taking this medication, tell your doctor if you have high blood pressure, angina, or heart disease; have had a stroke; have a bleeding or blood-clotting disorder; have breast, uterine, or another hormone-related cancer; have liver disease or a history of jaundice (yellowing of the skin and eyes) caused by use of birth control in the past; have undiagnosed, abnormal vaginal bleeding; have migraines; have asthma; or have seizures or epilepsy. You may not be able to take Trigynon, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. Trigynon are in the FDA pregnancy category X. This means that Trigynon will cause birth defects in an unborn baby. Hormonal changes during pregnancy can have very serious negative effects on a developing baby. Do not take Trigynon if you are pregnant or if you think you might be pregnant. The hormones in Trigynon pass into breast milk and may decrease milk production. Do not take Trigynon without first talking to your doctor if you are breast-feeding a baby.

How should I take my Trigynon? Take your Trigynon exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take the first pill in a package on the first Sunday after your period begins (unless otherwise directed by your doctor). Take one pill every day, no more than 24 hours after your last dose. Try to take the pills at a time that you will remember every day — for example just before bed, with a meal, or first thing in the morning. Taking your pill at night may help to reduce any nausea or headache that you may experience because of the hormones. If you are on a 28-day cycle, take one pill every day. When the pack runs out, throw it away. Begin a new pack the following day. The 28-day cycle contains seven pills that are either placebos (with no active ingredients) or iron supplements. These are “reminder” pills to keep you on your regular cycle. They are taken while you are menstruating. If you are on a 21-day cycle, take one pill every day for 21 days, then do not take any pills for 7 days. You should have your period during the 7 days with no pills. Resume your pills on the 8th day with a new package. Follow your doctor’s instructions about using a second form of birth control when you first start taking Trigynon, when you are taking antibiotics, or if you miss a pill. If you are unsure what to do in any of these cases, talk to your pharmacist, nurse, or doctor about how to ensure that you will not become pregnant. Store Trigynon at room temperature away from moisture and heat.

What happens if I miss a dose? Missing a pill increases the risk of becoming pregnant. Follow the exact directions on your package information insert concerning missed doses. If you do not have a package information insert, call your pharmacist, doctor, or nurse to find out what to do. In general: If you miss one dose, take it as soon as you remember or take two pills at the time of your next regularly scheduled dose. There is little likelihood that ovulation will occur. You may, however, want to use a second method of birth control such as a condom or a spermicidal cream, jelly, or foam for at least seven consecutive days following the missed tablet to ensure protection from pregnancy. If you miss two tablets in a row, take the two missed tablets as soon as you remember or with your next regularly scheduled dose (three total). Or, you may take two tablets each for the next two regularly scheduled doses (one missed tablet plus one regularly scheduled tablet for 2 days in a row). Chances are much greater that you may ovulate so you must use another form of birth control for at least 7 days following the missed tablets. It is even better to use a second method of birth control until your next period. If you miss three tablets in a row, throw away the package and start a new package on the 7th day after the last day you took a pill. Use another method of birth control until you have taken a pill for 7 days in a row. Your period should occur during the 7 days without pills. If it doesn’t, have a pregnancy test before beginning a new package of pills. Read all of the information in your package information insert. It may have slightly different instructions in the case of missed pills. Talk to your pharmacist, nurse, or doctor if you have any questions.

What happens if I overdose? Death is not likely to occur from an overdose of Trigynon. Consult a doctor, an emergency room, or a poison control left for advice. Symptoms of an overdose include nausea, vomiting, and menstrual bleeding.

What should I avoid while taking my Trigynon? Avoid smoking. Smoking greatly increases your risk of a heart attack, stroke, or blood clot formation. Trigynon do not protect you from sexually transmitted diseases — including HIV and AIDS.

What are the possible side effects of my Trigynon? If you experience any of the following serious side effects, stop taking your Trigynon and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); a blood clot in the lung (shortness of breath or pain in the chest); a blood clot in an arm or leg (pain, redness, swelling, or numbness of an arm or leg); high blood pressure (severe headache, flushing, blurred vision); or liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue). Other, less serious side effects may be more likely to occur. Continue to take your Trigynon and talk to your doctor if you experience headache or dizziness; nausea, vomiting, or diarrhea; breakthrough bleeding; or breast tenderness. These side effects may disappear or be less noticeable after 3 to 6 months of birth control use. Ask your doctor or pharmacist for advice if you find any side effect very bothersome. The side effects listed below generally occur very rarely and are not considered serious. If you experience any of the following, talk to your doctor: depression, changes in weight or appetite, vaginal yeast infection, changes in your menstrual cycle, oily skin or acne, changes in your sex drive, lethargy or fatigue, bloating, changes in your skin color, or changes in your blood sugar. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect my Trigynon? Some drugs may decrease the effectiveness of Trigynon, which may result in pregnancy. Use a second form of birth control if you are taking a penicillin antibiotic such as amoxicillin (Amoxil, Polymox, Trimox, Wymox, Utimox, A-Cillin, Larotid, Augmentin, others), ampicillin (Principen, Omnipen, Penamp, Polycillin, Amplin, Amcill, Totacillin, others), bacampicillin (Spectrobid), carbenicillin (Geocillin), cloxacillin (Cloxapen, Tegopen), dicloxacillin (Dynapen, Dycill, Pathocil), nafcillin (Nafcil, Nallpen, Unipen), oxacillin (Bactocill, Prostphlin), or penicillin (Veetids, Pen Vee K, Bicillin, Permapen, others); a tetracycline antibiotic such as demeclocycline (Declomycin), doxycycline (Doryx, Doxy, Vibramycin, Vibra-Tabs, others), minocycline (Minocin), or tetracycline (Sumycin, Teracyn, Achromycin, Robitet, Panmycin, others); a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); rifampin (Rifadin); phenytoin (Dilantin); carbamazepine (Tegretol); or griseofulvin (Grisactin, Grifulvin V, Fulvicin PG). Drugs other than those listed here may also interact with Trigynon. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

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Docusate Report For Patients Like You, Genasoft

Docusate treatment report

See 14 evaluations from 12 patients with major perceived effectiveness

See 41 evaluations from 37 patients with moderate perceived effectiveness

See 21 evaluations from 21 patients with slight perceived effectiveness

See 5 evaluations from 5 patients with none perceived effectiveness

See 1 evaluation from 1 patient with unknown perceived effectiveness

This item is relevant to you: Bowel problems

See 2 evaluations from 2 patients with major perceived effectiveness

See 14 evaluations from 12 patients with moderate perceived effectiveness

See 8 evaluations from 8 patients with slight perceived effectiveness

See 0 evaluations from 0 patients with none perceived effectiveness

See 1 evaluation from 1 patient with unknown perceived effectiveness

This item is relevant to you: General health

See 0 evaluations from 0 patients with major perceived effectiveness

See 0 evaluations from 0 patients with moderate perceived effectiveness

See 0 evaluations from 0 patients with slight perceived effectiveness

See 0 evaluations from 0 patients with none perceived effectiveness

See 0 evaluations from 0 patients with unknown perceived effectiveness

See 1 evaluation from 1 patient with major perceived effectiveness

See 3 evaluations from 3 patients with moderate perceived effectiveness

See 0 evaluations from 0 patients with slight perceived effectiveness

See 0 evaluations from 0 patients with none perceived effectiveness

See 1 evaluation from 1 patient with unknown perceived effectiveness

This item is relevant to you: Hemorrhoids

See 0 evaluations from 0 patients with major perceived effectiveness

See 3 evaluations from 3 patients with moderate perceived effectiveness

See 0 evaluations from 0 patients with slight perceived effectiveness

See 0 evaluations from 0 patients with none perceived effectiveness

See 0 evaluations from 0 patients with unknown perceived effectiveness

See 1 evaluation from 1 patient with major perceived effectiveness

See 0 evaluations from 0 patients with moderate perceived effectiveness

See 3 evaluations from 3 patients with slight perceived effectiveness

See 0 evaluations from 0 patients with none perceived effectiveness

See 0 evaluations from 0 patients with unknown perceived effectiveness

What is docusate?

Docusate is a stool softener. It makes bowel movements softer and easier to pass.

Docusate is used to treat constipation, and to reduce pain or rectal damage caused by hard stools or by straining during bowel movements.

Docusate may also be used for other purposes not listed in this medication guide.

Precautions

You should not use this medication if you are allergic to docusate.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using docusate, tell your doctor if you have:

an intestinal disorder such as Crohn's disease or ulcerative colitis; or

stomach pain, nausea, or vomiting.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether docusate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Avoid using laxatives or other stool softeners unless your doctor has told you to.

Instructions

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting or stomach pain.

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using docusate and call your doctor at once if you have a serious side effect such as:

rectal bleeding;

severe stomach pain, nausea, vomiting; or

no bowel movement.

Less serious side effects may include:

a bitter taste or throat irritation;

skin rash;

diarrhea; or

mild nausea.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Interactions

Tell your doctor about all other medications you use, especially:

aspirin or products that contain aspirin; or

mineral oil.

This list is not complete and there may be other drugs that can interact with docusate. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Other Names

Aqualax, Calcium Stool Softener, Calube, Colace, Colace Micro-Enema, Correctol Softgel Extra Gentle, D-S Caps, DOK, DOS, DSS, Diocto, Dioctocal, Dioctosoftez, Dioctyn, Dionex, Doc-Q-Lace, Docu Soft, DocuSol, Docucal, Doculase, Docusoft S, Doss-Relief, Dulcolax Stool Softener, Enemeez Mini, Ex-Lax Stool Softener, Genasoft, Kao-Tin, Kaopectate Stool Softener, Kasof, Phillips Stool Softener, Regulax SS, Silace, Sur-Q-Lax, Surfak Stool Softener, Therevac-SB, docusate, DC-240, Dialose, Dioeze, Docu, Fleet Sof-Lax, Modane Soft, Octycine-100, Octycine-250, Sulfalax Calcium, and Sulfolax

Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

Last updated: September 19, 2016

What is the most important information I should know about docusate?

Before using docusate, tell your doctor if you have an intestinal disorder such as Crohn’s disease or ulcerative colitis, or stomach pain, nausea, or vomiting.

Do not take mineral oil or aspirin while using docusate, unless otherwise directed by your health care provider.

Call your doctor if your symptoms do not improve or if they get worse after using this medicine for 1 to 3 days.

Warning

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Diflucan - Anti Fungal, Alozof

Anti Fungal - Alozof (Brand name: diflucan)

Product Description Common use Diflucan is an anti-fungal antibiotic which is used to treat fungal infections called candidiasis. This medication is prescribed for the treatment of such type of infections as vaginal, throat and fungal infections, infections of the urinary tract, peritonitis, and pneumonia. Diflucan works by killing sensitive fungi by interfering with the formation of the fungal cell membrane.

Dosage and direction Take it orally once a day, with or without food using the measuring spoon. Take it at the same time each day with a full glass of water if you want to get the best result. Diflucan make you feel better after 24 hours. However, your symptoms will go away completely just after few days. If there is no change in your health after a few days consult your doctor immediately. The dosage for adults may vary from type of infection: 1) Genital thrush - 150mg as a single dose 2) Mucosal thrush - dose depends on where the infection is located 50mg once daily during month. 3)Fungal skin infections - 50mg once daily for 2-4 weeks ; 4) Internal fungal infections 400mg on the first day then 200-400mg once daily for 6-8 weeks or longer if needed. 5) To stop you from getting fungal infections - 50-400mg once daily while you have risk to get an infection; 6) To stop infection caused by Cryptococcus from coming back - 100-200mg once daily indefinitely The dosage for children 4 weeks to 15 years old may also vary from type of infection: 1) mucosal infections - 3mg/kg once daily; 2)internal fungal infections - 6-12mg/kg once daily; 3)prevention of fungal infections - 3-12mg/kg once daily while at risk of getting an infection. For children 2-4 weeks old it is same dose as above but given once every 2 days. A maximum dose of 12mg/kg every 2 days. For children less than 2 weeks old it is same dose as above but given once every 3 days. Do not give more then 12mg/kg every 3 days. Note: this instruction presented here is just for review. It's very necessary to consult your doctor before using. It will help you to get best results.

For vaginal yeast infections, doctors usually prescribe a single dose of Diflucan. If the yeast infection does not improve after 5 days, contact your doctor as soon as possible. Be careful with this medication if your medical history include liver disease or kidney disease. Although uncommon, this drug may make you dizzy, so be more attentive while you are driving or using machinery. Limit alcohol intake. Diflucan should not be used during pregnancy, lactation or if you plan to become pregnant without a doctor's advice. Do not use before breast-feeding without a doctor's advice.

Contraindications Diflucan is not allowed to people who have hypersensitivity to Fluconazole or other anti fungal azole preparations, eg clotrimazole, ketoconazole, itraconazole and other. Also Diflucan contraindicated in: Kidney and liver disorders; Cardiovascular diseases including heart diseases(heart rate or rhythm disturbances); Low blood levels of calcium, magnesium or potassium.

Possible side effect

They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); fever, chills, body aches, flu symptoms; severe blistering, peeling, and red skin rash; easy bruising or bleeding, unusual weakness; or seizure (convulsions). Less serious include: mild nausea, vomiting, diarrhea, or upset stomach; headache; dizziness; unusual or unpleasant taste in your mouth; or skin rash or itching. If you experience one of them stop using Diflucan and tell your doctor as soon as possible. Also consult your doctor about any side effect that seems unusual.

Drug interaction Diflucan interact with such medication as: a blood thinner such as warfarin (Coumadin) cyclosporine (Gengraf, Sandimmune, Neoral); an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), tolbutamide (Orinase), tolazamide (Tolinase), chlorpropamide (Diabinese), and others; rifabutin (Mycobutin) or rifampin (Rifadin, Rifater, Rifamate, Rimactane); a sedative such as diazepam (Valium), lorazepam (Ativan), alprazolam (Xanax), or midazolam (Versed); seizure medication such as phenytoin (Dilantin) or valproic acid (Depakene); tacrolimus ((Prograf); theophylline (Theo-Dur, Theolair, Theochron, Elixophyllin, Slo-Phyllin, others). Also note that interaction between two medications does not always mean that you must stop taking one of them. Usually it affects the the effect of drugs, so consult your doctor about the way these interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usual dose next day in the same time.

Overdose Symptoms of Diflucan overdose may include: confusion or unusual thoughts or behavior. If you experience one of them call your doctor immediately.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Lipitor - Cholesterol Lowering, Lipista

Common use Atorvastatin is a cholesterol-lowering used to treat high cholesterol or to lower the risk of stroke, heart attack or other heart complications in patients with coronary heart disease or second type of diabetes. Atorvastatin helps to clear harmful low-density lipoprotein cholesterol out of the blood and by limiting the body's ability to form new LDL cholesterol. Thus it can help prevent hardening of the arteries and heart disease, conditions that can lead to vascular disease, heart attack, stroke.

Dosage and direction Take it orally once a day with or without food. Atorvastatine should be taken with full glass of water. The common dose for adults is 10 mg once daily. The common dose for children from 10 to 17 years of age is 10 mg once daily. Using Atorvastatin in children less than 10 years of age is not recommended and dose must be determined by your family doctor.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.

Precautions People with diabetes, underactive thyroid glands, kidney disease, or muscle disease sometimes need additional tests before or during atorvastatin therapy since dosage adjustments may be required. Do not use large amounts of alcohol while taking this drug because it can worsen the adverse effects of this medicine on the liver. Atorvastatin should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use Atorvastatin before breast-feeding without doctor's permission.

Contraindications Atorvastatin is not allowed to people who have liver problems or unexplained abnormal liver function tests. Do not use it if you are taking an HIV protease inhibitor (eg, ritonavir), itraconazole, or mibefradil. Also Atorvastatin contraindicated if you are hypersensitive to any components of this medication, pregnancy or breast-feeding.

Possible side effect They may include all types of an allergic reaction. Also the most possible side effects include: muscle pain, tenderness, or weakness with fever or flu symptoms; or nausea, clay-colored stools, stomach pain, low fever, jaundice, loss of appetite, dark urine. Less serious include: mild nausea or stomach pain, stomach upset, heartburn; constipation, bloating, gas; stuffy nose; itching, skin rash; headache. If you experience one of them stop using Atorvastatin and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Atrovastatin interact with the following drugs: digoxin; erythromycin or clarithromycin; gemfibrozil or fenofibrate; niacin; an antifungal medication such as itraconazole, fluconazole, or ketoconazole; drugs that weaken your immune system such as cancer medicine or steroids, cyclosporine, sirolimus, tacrolimus, and others; HIV or AIDS medication such as indinavir, nelfinavir, ritonavir, lopinavir-ritonavir, or saquinavir. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Symptoms of Atorvastatin are not known well but most possible of them include a severe drop in blood pressure and a faster heartbeat. If you experience one of them or any unusual symptoms, call your doctor immediately.

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Sartin’S Seafood - 37 Photos & 38 Reviews - Seafood - 3520 Nederland Ave, Nederland, Tx - Restaurant

Sartin’s Seafood

It's been many years since I've been to Sartin's since I have moved from the area. I had to stop to try the BBQ crabs. Having lived in Louisiana, Houston, and Mexico, I know this dish is hard to find. They were out! I somehow "remembered" how good they were many, many years ago. I ended up ordering fried shrimp and fish. They were wonderful. I also got a small salad that was great. Fresh seafood at great prices In a casual setting! I will have to try to stop by next time I'm driving near this area to get those BBQ crabs again.

Was this review …?

SCRRRR. scrrrrrr. scrrrrrrr. Do you hear that? That's me unknowingly going against the grain. I was told by two of my fellow yelpers who have never let me down to 'Go to Sartin's!". I was so excited that I got the time that I even forgot my wallet where I stayed at, no worries, I got it as well as another friend and came back. (Note, they don't trust people to eat, come back and pay even if you leave an important document like a TWIC card but I get it, it's a business).

The outside will render you wondering if you've stepped into a hole in the wall with a jewel hidden inside and the parking (if you find a spot) will tell you that you are lucky to get one. Let's not judge a book by it's cover right? Step on in, you will be greeted and seated.

The first thing you will notice are the cheesy $40 walmart tables that will be room enough for 2 people, 4 in a crunch. Don't lean on them or they will slip out from you on the cement floor.

The second thing you might notice is the open "server" area where you get to watch them make and pour your drinks and/or iced tea. Kind of like an economy apartment with no walls except for the bathroom maybe? Ok, let's try the menu items.

I ordered the "top of the line" item which could be considered the fried platter. It consists of fried shrimp, two bbq crabs (with a lot of seasoning. and then some. ), hush puppies, cole slaw and a fish plank. Oysters were supposed to come with it but was told that they do not have any because it's "out of season". strike 3, I'm outta here.

The flagship "bbq crabs" that the other people are talking about. well, they were pretty good but be prepared to ask for plenty of water if you know what I mean, and no, I don't mean that they were spicy.

The positive notes I can say about this place is the service is pretty attentive and the people always checked up on us including the "manager"? The cole slaw was one of the best that I have tasted in this town and there is another location in the neighboring city of Beaumont that you can go to if this one does not strike your fancy. Guess where I will probably go next week?

Have a great day folks and I hope that you will have the chance to try here and prove me wrong, just don't forget to bring your wallet.

I heard this place was supposed to be THE place to go. Overall, pretty disappointed with my visit. I had the all-you-can-eat plate: the fried shrimp were tasty, everything else was just humdrum. Service was pretty unimpressive in my section, but I saw waitstaff really humping it elsewhere in the restaurant.

I'm really not sure if I will revisit this place for a second chance.

Was this review …?

31 years. Maybe I'm confused but their original location was just as good 31 years ago. I brought my youngest son here tonight (we are visiting Lamar University as a possible college for him to attend) and he loved it too. Second best seafood I've ever had behind a Port Arthur legend the Farm Royal (no longer there unfortunately).

Was this review …?

No oysters today. Tried my first blue crabs n with a market price of $35 a lb. I'm not impressed. With a lot of work..the few bites I managed to get were sweet but..not enough for the hassle. Good shrimp poe boy n wonderful onion rings. Beer was cold. Waitress was sweet n she sent the manager out to help me learn how to eat the crabs. Richard got the shrimp trio. Loaded tator..slaw. The hushpuppies were delicious. I will probably visit here again but only when they have fresh oysters in stock.

These were cute. local coloring pages of crabs

Shrimp poe boy..great onion rings

Wow is the first word that enters my head after trying their all you can eat fried seafood basket! The batter coating is perfect, not to oily, and perfect texture. best Fish fry I've ever had. Unfortunately i'm from San Diego and not Texas Big (average size) otherwise I would have had basket after basket after basket. etc. Lastly the price was definitely right, ate dinner there 2 of my 4 nights there. Thanks Sartin Crew. )

Was this review …?

So let me start out by saying this. I don't particularly care for blue crabs unless it's in a crab cake. What drew me in were the reviews and the constant mention of bbq crabs! Never heard of such a thing but it intrigued me. The pictures people posted only furthered my curiosity. So I scan the menu looking for the dish. I selected a combo dish of the bbq crabs and fried catfish. While scanning the menu I realized these bbq crabs were actually fried. I've never had fried crab either. still wanted it. I received my dish with a mound of crab on it. I had to ask for a bit of instruction just to assure myself I knew what I was doing. So I dove right in. I had to get my hands a bit dirty. I dislike getting dirty. but these crabs were worth it and tasty! The crabs are actually fried in a special seasoning. You gotta try it! This is probably the only way I will ever eat blue crabs from here on out! Definitely worth trying and very unique!

Was this review …?

WOW. The food here is spectacular. The atmosphere is rustic, but personally I like that. Our waiter was a little slow but it was very busy and the food was definitely worth the drive. We will definitely be back. The seafood platters are worth the price. I had the baked seafood platter and it was beyond 5 stars. The crab dip and crab balls are delicious. I can't wait to go back !

Was this review …?

Sartin's motto is "we've got the crabs". That would be a horrible motto for an individual, but for a seafood restaurant, it works.

I'm not sure if they invented the concept of BBQ crabs, but they are definitely known for that dish.

What are BBQ crabs you ask? They are nothing like New Orleans style BBQ shrimp which were handed down from the lord himself. They aren't barbecued in the traditional way. They are fried. I have no idea where the name comes from, but people love them.

I have only tasted the BBQ crabs and it wasn't my thing. The people I was with must have eaten several bushels. They absolutely loved them. I got a fried shrimp platter which was pretty good. The shrimp were obviously fresh and cooked perfectly.

If you want crabs, you now know where to go.

Was this review …?

Sartin’s Seafood

It's been many years since I've been to Sartin's since I have moved from the area. I had to stop to try the BBQ crabs. Having lived in… Read More

It's been many years since I've been to Sartin's since I have moved from the area. I had to stop to try the BBQ crabs. Having lived in Louisiana, Houston, and Mexico, I know this dish is hard to find. They were out! I somehow "remembered" how good they were many, many years ago. I ended up ordering fried shrimp and fish. They were wonderful. I also got a small salad that was great. Fresh seafood at great prices In a casual setting! I will have to try to stop by next time I'm driving near this area to get those BBQ crabs again.

Ate there last night, took my for first time She loved it. Food was well prepared, not overcooked or greasy. I tend eat there on my trips… Read More

Ate there last night, took my for first time She loved it. Food was well prepared, not overcooked or greasy. I tend eat there on my trips down here (hometown). It is what it is, casual, bit noisy and good food. Prices are about what you expect, never been anywhere where they gave it away.

SCRRRR. scrrrrrr. scrrrrrrr. Do you hear that? That's me unknowingly going against the grain. I was told by two of my… Read More

SCRRRR. scrrrrrr. scrrrrrrr. Do you hear that? That's me unknowingly going against the grain. I was told by two of my fellow yelpers who have never let me down to 'Go to Sartin's!". I was so excited that I got the time that I even forgot my wallet where I stayed at, no worries, I got it as well as another friend and came back. (Note, they don't trust people to eat, come back and pay even if you leave an important document like a TWIC card but I get it, it's a business).

The outside will render you wondering if you've stepped into a hole in the wall with a jewel hidden inside and the parking (if you find a spot) will tell you that you are lucky to get one. Let's not judge a book by it's cover right? Step on in, you will be greeted and seated.

The first thing you will notice are the cheesy $40 walmart tables that will be room enough for 2 people, 4 in a crunch. Don't lean on them or they will slip out from you on the cement floor.

The second thing you might notice is the open "server" area where you get to watch them make and pour your drinks and/or iced tea. Kind of like an economy apartment with no walls except for the bathroom maybe? Ok, let's try the menu items.

I ordered the "top of the line" item which could be considered the fried platter. It consists of fried shrimp, two bbq crabs (with a lot of seasoning. and then some. ), hush puppies, cole slaw and a fish plank. Oysters were supposed to come with it but was told that they do not have any because it's "out of season". strike 3, I'm outta here.

The flagship "bbq crabs" that the other people are talking about. well, they were pretty good but be prepared to ask for plenty of water if you know what I mean, and no, I don't mean that they were spicy.

The positive notes I can say about this place is the service is pretty attentive and the people always checked up on us including the "manager"? The cole slaw was one of the best that I have tasted in this town and there is another location in the neighboring city of Beaumont that you can go to if this one does not strike your fancy. Guess where I will probably go next week?

Have a great day folks and I hope that you will have the chance to try here and prove me wrong, just don't forget to bring your wallet.

I heard this place was supposed to be THE place to go. Overall, pretty disappointed with my visit. I had the all-you-can-eat plate: the… Read More

I heard this place was supposed to be THE place to go. Overall, pretty disappointed with my visit. I had the all-you-can-eat plate: the fried shrimp were tasty, everything else was just humdrum. Service was pretty unimpressive in my section, but I saw waitstaff really humping it elsewhere in the restaurant.

I'm really not sure if I will revisit this place for a second chance.

Crystal Y.

ALWAYS A-M-A-Z-I-N-G. Absolutely delicious. Hit the spot. Great staff/service. Will be back.

Xandria M.

I love this place! My favorite seafood restaurant. Seafoods are fresh and cooked deliciously!

View More Reviews

See all 38 reviews in the app!

Aryn B.

I used to be literally in awe of this spot - and would gleefully trek from Houston for mindblowing BBQ crabs. But over the last several years the prices have increased markedly and the quality has headed the opposite direction. Big bummer.

Hollis P.

Ate there last night, took my for first time She loved it. Food was well prepared, not overcooked or greasy. I tend eat there on my trips down here (hometown). It is what it is, casual, bit noisy and good food. Prices are about what you expect, never been anywhere where they gave it away.

Katie B.

Expensive, fries were fried in seafood grease, crab ballsstuffed crabimitation crab meat. for 15 dollars! Nah. I'll make my own thanks.

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Example: There are a few times in life when a meal is so expertly crafted and planned that it is nothing short of genius. Last night, I had one of those meals - the Mahi Mahi.

The dish was excellently prepared. Grilled, juicy, and fresh without a hint of fishiness. A glaze of tangerine sauce brought a hint of tart sweetness. The fish was placed on a mound of sweet plantain rice. The combination of the fish and rice alone was to die for!

However, as only expert chefs can achieve, additional garnishes provided even bolder, beautiful tastes. Pickled onions topping the fish made for an even finer taste experience, while green beans hidden under the fish added freshness and completed each bite

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We are known for our BBQ Crabs.

History

Established in 1997.

This Restaurant originated from a family business that started 30 years ago. We are "World Famous" for our BBQ Crabs! I am the owner of the location in Nederland, Texas. I have had Sartin's since 1997. The experience here is handed down from parents to their kids, special occasions or just get togethers, special memories take place everyday. We always hear someone comment "our kids are coming into town and they tell us to meet them at "Sartin's". We have had customers even just fly in to the local airport and get food to take home! We are also know for our "All You Can Eat " platter service. It consist of fried shrimp, bbq crabs, fries, hush puppies and salad bar for 26.99. We offer grilled items as well, steaks and chicken dinners for the non seafood customers. We are open everyday. Give us a call for the hours and I hope to see you soon!

Thanks, Kim Tucker

Meet the Business Owner: Kim T.

I started in the restaurant business when I was seventeen years old! I acquired Sartin's in 1997. Being a restaurant owner is not easy but very rewarding! I live and breathe running a restaurant. As of March of this year 2011 I have taken on another job since Sartin's is now allowing me to do so. I am the DIrector of Culinary Services at Atria Collier Park in Beaumont, Texas. I remarried in 2006 to Troy Tucker. I am the mother of two sons, Doug,23 and Owen, 3. I am thankful to my family, customers because without them I would not be where or who I am today! Having a restaurant and happy customers will always put a smile on my face. Our dedicated customers sometimes eat with us three times a week! We also give a loyal card out to give back to our customers for their frequent visits. It is now twenty four years later and we are going stronger than ever.

Sartin's Seafood

Tu Medico, Prebloc

Composicion: Fumarato de bisoprolol 5 mg y 10 mg /tableta recubierta.

Farmaco: Aparato Circulatorio.

Presentacion: Tab recubiertas: Estuche con 30 de 5 y 10 mg. E. F. 35.201 y 35.395.

Dosificacion: 2,5 mg a 10 mg diarios. Individualizar la dosis a las necesidades del paciente. Tratamiento de la hipertension o cardiopatia isquemica cronica: Dosis usual de arranque: 5 mg 1 v/dia. Si el efecto antihipertensivo de 5 mg es inadecuado, la dosis puede incrementarse a 10 mg. En pacientes con deterioro hepatico o disfuncion renal: Dosis diaria inicial: 2,5 mg - usar con precaucion en la titulacion de la dosis, puesto que los datos limitados sugieren que el fumarato de bisoprolol no es dializable. No es necesario el reemplazo de la droga en pacientes sometidos a dialisis. No es necesario ajustar la dosis en pacientes ancianos, a menos que tambien haya una disfuncion renal o hepatica de importancia. No hay experiencia pediatrica con bisoprolol.

Indicaciones: Tratamiento de la hipertension y cardiopatia isquemica cronica. Puede usarse solo o en combinacion con otros agentes antihipertensivos.

Contra Indicaciones: Administracion concomitante con farmacos que depleten los depositos de catecolaminas (ej. reserpina) o los inhibidores de la monoamino - oxidasa. Shock cardiogenico, falla cardiaca evidente, bloqueo auriculo - ventricular de segundo o tercer grado, marcada bradicardia.

Reacciones Adversas: Generalmente es bien tolerado. La mayoria son leves y transitorias. Algunos pacientes pueden reportar cefalea, mareos, vertigo y fatiga, especialmente en las fases tempranas del tratamiento. Ellos pueden disminuirse con el uso continuo del farmaco. Otros efectos adversos: Bradicardia, bron-coespasmo, parestesia, insomnio, gastralgia, nauseas, diarrea, boca seca, erupciones, isquemia periferica, hipokalemia, hiperuricemia.

Precauciones: Debe realizarse control periodico de la funcion renal y hepatica en pacientes con funcion hepatica deteriorada o enfermedad hepatica progresiva. Realizar controles periodicos de la funcion renal, niveles de electrolitos y acido urico. Pacientes en tratamiento con hipogliceminates orales o insulina. Evitar los agentes B-bloqueantes en pacientes con falla cardiaca evidente. La depresion continua al miocardio con los B-bloqueadores puede precipitar falla cardiaca. A los primeros signos o sintomas de falla cardiaca, debe considerarse la interrupcion de la droga. Evitar el cese abrupto de los B-bloqueadores. Incluso en pacientes sin enfermedad de la arteria coronaria notable, puede ser aconsejable reducir la terapia por aprox 1 semana con el paciente bajo observacion cuidadosa. Si ocurren los sintomas del retiro, restituir la terapia con agentes B-bloqueantes, al menos temporalmente. Usar B-bloqueadores con precaucion en pacientes con enfermedad vascular periferica. Pacientes con enfermedad pulmonar broncoespastica no deben recibir B-bloqueadores. Si se usa preoperatorio (cerca del momento de la operacion) tomar cuidados particulares cuando se usan agentes anestesicos que deprimen la funcion del miocardio (ej. eter, ciclopropano y tricloroetileno). Los B-bloqueadores pueden enmascarar algunas de las manifestaciones de la hipoglicema, particularmente la taquicardia. Los pacientes diabeticos que reciben insulina o agentes hipoglicemicos orales deben ser cautelosos. Tambien la Diabetes mellitus puede volverse manifiesta y los pacientes que reciben tiazidas pueden requerir ajuste de su dosis de insulina. El bloqueo B-adrenergico puede enmascarar los signos clinicos del hipertiroidismo. El retiro abrupto del B-blo-queo puede continuar con una exacerbacion de los sintomas del hipotiroidismo. En sujetos con depuracion de creatinina

Isocor, Ibm Release Isp Messaging Software, Isocor

ISOCOR, IBM Release ISP Messaging Software

Aimed at providing outsourced messaging solutions for Internet service providers, ISOCOR and IBM Tuesday unveiled ISOCOR's N-PLEX Internet Messaging server software for IBM's RS/6000 server.

N-PLEX is a server capable of handling large-scale, high-volume messaging requirements. Supporting millions of users, N-PLEX can address specific ISP and enterprise requirements with integrated standards-based directory services and management facilities.

ISOCOR and IBM have worked jointly together to port N-PLEX to AIX, IBM's UNIX operating system, the companies said. The messaging server software is designed to provide ISPs and business clients with reliable, high-performance outsourced messaging services with sophisticated message archiving features and "anti spam" protection from unsolicited bulk mail and computer viruses.

N-PLEX features a distributed message architecture that allows a large volume of users to be spread across multiple servers throughout a wide geographical area within a single domain. This enables all Internet mail users to share the same mail domain name, even though their actual message mailbox is located on another server with a different IP address and domain name. In addition, all components of N-PLEX can be monitored remotely from one central management station.

N-PLEX for AIX is available immediately through IBM, IBM Business Partners or from ISOCOR directly.

"We are delighted to be able to deliver our flagship product, N-PLEX Messaging Server, to the IBM environment -- allowing ISPs to leverage IBM expertise in server, storage and clustering technology," said Paul Gigg, ISOCOR's president and chief executive officer.

"We believe that together, our products can provide a winning combination of mission-critical scalability and high-performance ideal for any ISP providing the value-added services required by today's Internet community," Gigg said.

"Today's announcement means that IBM can now provide ISPs and enterprise customers which use ISOCOR's messaging and directory software with an advanced hardware platform for mission-critical Internet applications," said Debra Thompson, vice president, segments and product marketing, IBM RS/6000. "The RS/6000 provides the high level of scalability and reliability that the fast-moving ISP market needs."

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