Occur - Definition Of Occur In English, Ocupred

Definition of occur in English:

‘the accident occurred at about 3.30 p. m.’

More example sentences

‘The event in question occurred some five years prior to the incident.’

‘But then two incidents occurred only a month apart in 1988.’

‘The functional impairments secondary to osteoarthritis also occur more frequently in older adults.’

‘Demonization usually occurs only in certain areas of a person's life.’

‘Changes often occur in the regions of the mouth where tobacco is placed.’

‘Keep in mind, however, that the most serious accidents typically occur during deer season.’

‘But by mid-afternoon on Monday an unrelated incident occurred which will cause further interruptions in water supply.’

‘Several short-term wins occurred as a result of the formation of the College Connection.’

‘Consequently accidents still occur due to a lack of awareness of the dangers involved with electricity.’

‘Death usually occurs within a few weeks to a year.’

‘Of course, events do occur which accelerate the processes by which people become conscious.’

‘Much of this growth has occurred as a result of the charismatic or Pentecostal movement.’

‘Also it was found that recombination events often occur in gene-rich areas.’

‘So the wedding would have occurred sometime in the first week of October.’

‘Most accidents occur due to a lack of discipline and a leader's failure to enforce standards.’

‘The more recent phase of integration has occurred against the backdrop of globalization.’

‘Hallucinations usually occur only at particular times and places, and are associated with the events hoped for.’

‘The offences occurred over a period of around three days in July last year.’

‘An air bag is designed to protect a driver or passenger in the event that an accident occurs.’

‘In 1847 an incident occurred which seriously weakened his position.’

happen . take place, come about, transpire, materialize, chance, arise, crop up, turn out, fall, come, fall out, pass off

1.1 Exist or be found to be present in a place or under a particular set of conditions.

‘radon occurs naturally in rocks such as granite’

More example sentences

‘Although most often accompanied by significant ascites, it can occur in its absence.’

‘Whether or not this occurs in vivo is not yet known.’

‘The data show that aggregation will occur in the absence of detectable plasma fibrinogen.’

‘Radioactivity occurs naturally in the earth and in the cosmic rays which reach the earth.’

‘The last appearance of D. murchisoni appears to occur at the same time across the region.’

‘They have spent the time analyzing the naturally occurring bacteria in abalone guts.’

‘EPO and HGH are both naturally occurring substances within the body and as such are hard to detect.’

‘Anthrax is a naturally occurring bacterium that exists in the form of spores which allow it to survive in the environment.’

‘Does ozone occur naturally at ground level and is it safe to breathe?’

‘Other elements occur naturally in a pure or elemental form, like sulphur or gold.’

‘Mercifully, though, deaths caused by naturally occurring anthrax are rare these days.’

‘These agents are naturally occurring and are deadly to humans even without being weaponized.’

‘Bromide is a naturally occurring trace chemical which has a sedative effect.’

‘On average, nodes preceding gene duplications occur earlier in the phylogenetic trees than speciation nodes.’

‘AAV is a naturally occurring virus that depends on a helper virus for replication.’

‘Silica is rare but when present occurs in vascular bundle sheath cells in both the leaf sheath and leaf blade.’

‘The virus occurs naturally in many birds and is transmitted by Culex mosquitoes.’

‘Surface exposures of Ncogene sedimentary rocks occur only along the edges of the basin.’

‘Our analysis indicates that frequency encoding of biological T-cell functions occurs under physiological conditions.’

‘It is probable that every naturally occurring element is present in the outer core at least at trace levels.’

1.2 (of a thought or idea) come into the mind of.

[with clause] ‘it occurred to him that he hadn't eaten’

More example sentences

‘There was some time left before the lesson started and an idea suddenly occurred to me.’

‘If you have an idea, throw it in - even if it occurs to you in the middle of a show.’

‘It just occurs to me that this may be what is behind this idea of real money.’

‘He would often get up from bed at night when an idea occurred to him and write it down.’

‘I leaned over again so that I could see it more clearly, then an idea occurred to me.’

‘An idea occurred to James at that moment and he allowed a small smile to play on his lips.’

‘The idea had occurred to him during a coffee break at his session the previous afternoon.’

‘It is not surprising that such an idea would occur to a writer in the Hispanic world.’

‘She turned her eyes down to the paw she held, several ideas occurring to her simultaneously.’

‘The idea of putting it online did occur to me, but I don't know if I'd actually do it.’

Origin

Late 15th century: from Latin occurrere go to meet, present itself, from ob - against + currere to run.

Pronunciation:

Buy Nifostin Azithromycin Online Without Prescriptions, Nifostin

Zithromax is used for treating mild to moderate infections caused by certain bacteria. It may also be used alone or with other medicines to treat or prevent certain infections in persons with advanced HIV infection. Zithromax is a macrolide antibiotic. It slows the growth of, or sometimes kills, sensitive bacteria by reducing the production of important proteins needed by the bacteria to survive.

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Lioresal Intrathecal - Fda Prescribing Information, Side Effects And Uses, Lioresal Intratecal

Lioresal Intrathecal

Abrupt discontinuation of intrathecal baclofen, regardless of the cause, has resulted in sequelae that include high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, that in rare cases has advanced to rhabdomyolysis, multiple organ-system failure and death.

Prevention of abrupt discontinuation of intrathecal baclofen requires careful attention to programming and monitoring of the infusion system, refill scheduling and procedures, and pump alarms. Patients and caregivers should be advised of the importance of keeping scheduled refill visits and should be educated on the early symptoms of baclofen withdrawal. Special attention should be given to patients at apparent risk (e. g. spinal cord injuries at T-6 or above, communication difficulties, history of withdrawal symptoms from oral or intrathecal baclofen). Consult the technical manual of the implantable infusion system for additional postimplant clinician and patient information (see WARNINGS ).

Lioresal Intrathecal Description

LIORESAL ® INTRATHECAL (baclofen injection) is a muscle relaxant and antispastic. Its chemical name is 4-amino-3-(4-chlorophenyl) butanoic acid, and its structural formula is:

Baclofen is a white to off-white, odorless or practically odorless crystalline powder, with a molecular weight of 213.66. It is slightly soluble in water, very slightly soluble in methanol, and insoluble in chloroform. Lioresal Intrathecal is a sterile, pyrogen-free, isotonic solution free of antioxidants, preservatives or other potentially neurotoxic additives indicated only for intrathecal administration. The drug is stable in solution at 37° C and compatible with CSF. Each milliliter of Lioresal Intrathecal contains baclofen U. S.P. 50 mcg, 500 mcg or 2000 mcg and sodium chloride 9 mg in Water for Injection; pH range is 5.0-7.0. Each ampule is intended for SINGLE USE ONLY. Discard any unused portion. DO NOT AUTOCLAVE .

Lioresal Intrathecal - Clinical Pharmacology

The precise mechanism of action of baclofen as a muscle relaxant and antispasticity agent is not fully understood. Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level, possibly by decreasing excitatory neurotransmitter release from primary afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect. Baclofen is a structural analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), and may exert its effects by stimulation of the GABA B receptor subtype.

Lioresal Intrathecal when introduced directly into the intrathecal space permits effective CSF concentrations to be achieved with resultant plasma concentrations 100 times less than those occurring with oral administration.

In people, as well as in animals, baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression.

Pharmacodynamics of Lioresal Intrathecal:

Adult Patients: The onset of action is generally one-half hour to one hour after an intrathecal bolus. Peak spasmolytic effect is seen at approximately four hours after dosing and effects may last four to eight hours. Onset, peak response, and duration of action may vary with individual patients depending on the dose and severity of symptoms.

Pediatric Patients: The onset, peak response and duration of action is similar to those seen in adult patients.

Lioresal Intrathecal’S antispastic action is first seen at 6 to 8 hours after initiation of continuous infusion. Maximum activity is observed in 24 to 48 hours.

Continuous Infusion: No additional information is available for pediatric patients.

Pharmacokinetics of Lioresal Intrathecal:

The pharmacokinetics of CSF clearance of Lioresal Intrathecal calculated from intrathecal bolus or continuous infusion studies approximates CSF turnover, suggesting elimination is by bulk-flow removal of CSF.

Intrathecal Bolus: After a bolus lumbar injection of 50 or 100 mcg Lioresal Intrathecal in seven patients, the average CSF elimination half-life was 1.51 hours over the first four hours and the average CSF clearance was approximately 30 mL/hour.

Continuous Infusion: The mean CSF clearance for Lioresal Intrathecal (baclofen injection) was approximately 30 mL/hour in a study involving ten patients on continuous intrathecal infusion. Concurrent plasma concentrations of baclofen during intrathecal administration are expected to be low (0-5 ng/mL).

Limited pharmacokinetic data suggest that a lumbar-cisternal concentration gradient of about 4:1 is established along the neuroaxis during baclofen infusion. This is based upon simultaneous CSF sampling via cisternal and lumbar tap in 5 patients receiving continuous baclofen infusion at the lumbar level at doses associated with therapeutic efficacy; the interpatient variability was great. The gradient was not altered by position.

Six pediatric patients (age 8-18 years) receiving continuous intrathecal baclofen infusion at doses of 77-400 mcg/day had plasma baclofen levels near or below 10 ng/mL.

INDICATIONS

Lioresal Intrathecal (baclofen injection) is indicated for use in the management of severe spasticity. Patients should first respond to a screening dose of intrathecal baclofen prior to consideration for long term infusion via an implantable pump. For spasticity of spinal cord origin, chronic infusion of Lioresal Intrathecal via an implantable pump should be reserved for patients unresponsive to oral baclofen therapy, or those who experience intolerable CNS side effects at effective doses. Patients with spasticity due to traumatic brain injury should wait at least one year after the injury before consideration of long term intrathecal baclofen therapy. Lioresal Intrathecal is intended for use by the intrathecal route in single bolus test doses (via spinal catheter or lumbar puncture) and, for chronic use, only in implantable pumps approved by the FDA specifically for the administration of Lioresal Intrathecal into the intrathecal space.

Spasticity of Spinal Cord Origin: Evidence supporting the efficacy of Lioresal Intrathecal was obtained in randomized, controlled investigations that compared the effects of either a single intrathecal dose or a three day intrathecal infusion of Lioresal Intrathecal to placebo in patients with severe spasticity and spasms due to either spinal cord trauma or multiple sclerosis. Lioresal Intrathecal was superior to placebo on both principal outcome measures employed: change from baseline in the Ashworth rating of spasticity and the frequency of spasms.

Spasticity of Cerebral Origin: The efficacy of Lioresal Intrathecal was investigated in three controlled clinical trials; two enrolled patients with cerebral palsy and one enrolled patients with spasticity due to previous brain injury. The first study, a randomized controlled cross-over trial of 51 patients with cerebral palsy, provided strong, statistically significant results; Lioresal Intrathecal was superior to placebo in reducing spasticity as measured by the Ashworth Scale. A second cross-over study was conducted in 11 patients with spasticity arising from brain injury. Despite the small sample size, the study yielded a nearly significant test statistic (p=0.066) and provided directionally favorable results. The last study, however, did not provide data that could be reliably analyzed.

Lioresal Intrathecal therapy may be considered an alternative to destructive neurosurgical procedures. Prior to implantation of a device for chronic intrathecal infusion of Lioresal Intrathecal, patients must show a response to Lioresal Intrathecal in a screening trial (see Dosage and Administration).

Contraindications

Hypersensitivity to baclofen. Lioresal Intrathecal is not recommended for intravenous, intramuscular, subcutaneous or epidural administration.

Warnings

Lioresal Intrathecal is for use in single bolus intrathecal injections (via a catheter placed in the lumbar intrathecal space or injection by lumbar puncture) and in implantable pumps approved by the FDA specifically for the intrathecal administration of baclofen. Because of the possibility of potentially life-threatening CNS depression, cardiovascular collapse, and/or respiratory failure, physicians must be adequately trained and educated in chronic intrathecal infusion therapy.

The pump system should not be implanted until the patient’s response to bolus Lioresal Intrathecal injection is adequately evaluated. Evaluation (consisting of a screening procedure: see Dosage and Administration) requires that LIORESAL INTRATHECAL be administered into the intrathecal space via a catheter or lumbar puncture. Because of the risks associated with the screening procedure and the adjustment of dosage following pump implantation, these phases must be conducted in a medically supervised and adequately equipped environment following the instructions outlined in the Dosage and Administration section.

Resuscitative equipment should be available.

Following surgical implantation of the pump, particularly during the initial phases of pump use, the patient should be monitored closely until it is certain that the patient’s response to the infusion is acceptable and reasonably stable.

On each occasion that the dosing rate of the pump and/or the concentration of Lioresal Intrathecal (baclofen injection) in the reservoir is adjusted, close medical monitoring is required until it is certain that the patient’s response to the infusion is acceptable and reasonably stable.

It is mandatory that the patient, all patient caregivers, and the physicians responsible for the patient receive adequate information regarding the risks of this mode of treatment. All medical personnel and caregivers should be instructed in 1) the signs and symptoms of overdose, 2) procedures to be followed in the event of overdose and 3) proper home care of the pump and insertion site.

Overdose: Signs of overdose may appear suddenly or insidiously. Acute massive overdose may present as coma. Less sudden and/or less severe forms of overdose may present with signs of drowsiness, lightheadedness, dizziness, somnolence, respiratory depression, seizures, rostral progression of hypotonia and loss of consciousness progressing to coma. Should overdose appear likely, the patient should be taken immediately to a hospital for assessment and emptying of the pump reservoir. In cases reported to date, overdose has generally been related to pump malfunction, inadvertent subcutaneous injection, or dosing error. (See Drug Overdose Symptoms and Treatment .)

Extreme caution must be used when filling an FDA approved implantable pump. Such pumps should only be refilled through the reservoir refill septum. Inadvertent injection into the subcutaneous tissue can occur if the reservoir refill septum is not properly accessed. Some pumps are also equipped with a catheter access port that allows direct access to the intrathecal catheter. Direct injection into this catheter access port or inadvertent injection into the subcutaneous tissue may cause a life-threatening overdose.

Withdrawal: Abrupt withdrawal of intrathecal baclofen, regardless of the cause, has resulted in sequelae that included high fever, altered mental status, exaggerated rebound spasticity and muscle rigidity that in rare cases progressed to rhabdomyolysis, multiple organ-system failure, and death. In the first 9 years of post-marketing experience, 27 cases of withdrawal temporally related to the cessation of baclofen therapy were reported; six patients died. In most cases, symptoms of withdrawal appeared within hours to a few days following interruption of baclofen therapy. Common reasons for abrupt interruption of intrathecal baclofen therapy included malfunction of the catheter (especially disconnection), low volume in the pump reservoir, and end of pump battery life; human error may have played a causal or contributing role in some cases. Cases of intrathecal mass at the tip of the implanted catheter leading to withdrawal symptoms have also been reported, most of them involving pharmacy compounded analgesic admixtures (see PRECAUTIONS ).

Prevention of abrupt discontinuation of intrathecal baclofen requires careful attention to programming and monitoring of the infusion system, refill scheduling and procedures, and pump alarms. Patients and caregivers should be advised of the importance of keeping scheduled refill visits and should be educated on the early symptoms of baclofen withdrawal.

All patients receiving intrathecal baclofen therapy are potentially at risk for withdrawal. Early symptoms of baclofen withdrawal may include return of baseline spasticity, pruritus, hypotension, and paresthesias. Some clinical characteristics of the advanced intrathecal baclofen withdrawal syndrome may resemble autonomic dysreflexia, infection (sepsis), malignant hyperthermia, neuroleptic-malignant syndrome, or other conditions associated with a hypermetabolic state or widespread rhabdomyolysis.

Rapid, accurate diagnosis and treatment in an emergency-room or intensive-care setting are important in order to prevent the potentially life-threatening central nervous system and systemic effects of intrathecal baclofen withdrawal. The suggested treatment for intrathecal baclofen withdrawal is the restoration of intrathecal baclofen at or near the same dosage as before therapy was interrupted. However, if restoration of intrathecal delivery is delayed, treatment with GABA-ergic agonist drugs such as oral or enteral baclofen, or oral, enteral, or intravenous benzodiazepines may prevent potentially fatal sequelae. Oral or enteral baclofen alone should not be relied upon to halt the progression of intrathecal baclofen withdrawal.

Seizures have been reported during overdose and with withdrawal from LIORESAL INTRATHECAL as well as in patients maintained on therapeutic doses of LIORESAL INTRATHECAL.

Fatalities: Spasticity of Spinal Cord Origin: There were 16 deaths reported among the 576 U. S. patients treated with LIORESAL INTRATHECAL (baclofen injection) in pre - and post-marketing studies evaluated as of December 1992. Because these patients were treated under uncontrolled clinical settings, it is impossible to determine definitively what role, if any, Lioresal Intrathecal played in their deaths.

As a group, the patients who died were relatively young (mean age was 47 with a range from 25 to 63), but the majority suffered from severe spasticity of many years duration, were nonambulatory, had various medical complications such as pneumonia, urinary tract infections, and decubiti, and/or had received multiple concomitant medications. A case-by-case review of the clinical course of the 16 patients who died failed to reveal any unique signs, symptoms, or laboratory results that would suggest that treatment with Lioresal Intrathecal caused their deaths. Two patients, however, did suffer sudden and unexpected death within 2 weeks of pump implantation and one patient died unexpectedly after screening.

One patient, a 44 year-old male with MS, died in hospital on the second day following pump implantation. An autopsy demonstrated severe fibrosis of the coronary conduction system. A second patient, a 52 year-old woman with MS and a history of an inferior wall myocardial infarction, was found dead in bed 12 days after pump implantation, 2 hours after having had documented normal vital signs. An autopsy revealed pulmonary congestion and bilateral pleural effusions. It is impossible to determine whether Lioresal Intrathecal contributed to these deaths. The third patient underwent three baclofen screening trials. His medical history included SCI, aspiration pneumonia, septic shock, disseminated intravascular coagulopathy, severe metabolic acidosis, hepatic toxicity, and status epilepticus. Twelve days after screening (he was not implanted), he again experienced status epilepticus with subsequent significant neurological deterioration. Based upon prior instruction, extraordinary resuscitative measures were not pursued and the patient died.

Spasticity of Cerebral Origin: There were three deaths occurring among the 211 patients treated with Lioresal Intrathecal in pre-marketing studies as of March 1996. These deaths were not attributed to the therapy.

Precautions

Children should be of sufficient body mass to accommodate the implantable pump for chronic infusion. Please consult pump manufacturer's manual for specific recommendations.

Safety and effectiveness in pediatric patients below the age of 4 have not been established.

Screening Patients should be infection-free prior to the screening trial with Lioresal Intrathecal (baclofen injection) because the presence of a systemic infection may interfere with an assessment of the patient’s response to bolus Lioresal Intrathecal.

Pump Implantation Patients should be infection-free prior to pump implantation because the presence of infection may increase the risk of surgical complications. Moreover, a systemic infection may complicate dosing.

Pump Dose Adjustment and Titration In most patients, it will be necessary to increase the dose gradually over time to maintain effectiveness; a sudden requirement for substantial dose escalation typically indicates a catheter complication (i. e. catheter kink or dislodgement).

Reservoir refilling must be performed by fully trained and qualified personnel following the directions provided by the pump manufacturer. Inadvertent injection into the subcutaneous tissue can occur if the reservoir refill septum is not properly accessed. Subcutaneous injection may result in symptoms of a systemic overdose or early depletion of the reservoir. Refill intervals should be carefully calculated to prevent depletion of the reservoir, as this would result in the return of severe spasticity and possibly symptoms of withdrawal.

Strict aseptic technique in filling is required to avoid bacterial contamination and serious infection. A period of observation appropriate to the clinical situation should follow each refill or manipulation of the drug reservoir.

Extreme caution must be used when filling an FDA approved implantable pump equipped with an injection port that allows direct access to the intrathecal catheter. Direct injection into the catheter through the catheter access port may cause a life-threatening overdose.

Additional considerations pertaining to dosage adjustment: It may be important to titrate the dose to maintain some degree of muscle tone and allow occasional spasms to: 1) help support circulatory function, 2) possibly prevent the formation of deep vein thrombosis, 3) optimize activities of daily living and ease of care.

Except in overdose related emergencies, the dose of Lioresal Intrathecal should ordinarily be reduced slowly if the drug is discontinued for any reason.

An attempt should be made to discontinue concomitant oral antispasticity medication to avoid possible overdose or adverse drug interactions, either prior to screening or following implant and initiation of chronic Lioresal Intrathecal infusion. Reduction and discontinuation of oral anti-spasmotics should be done slowly and with careful monitoring by the physician. Abrupt reduction or discontinuation of concomitant antispastics should be avoided.

Drowsiness: Drowsiness has been reported in patients on Lioresal Intrathecal. Patients should be cautioned regarding the operation of automobiles or other dangerous machinery, and activities made hazardous by decreased alertness. Patients should also be cautioned that the central nervous system depressant effects of Lioresal Intrathecal (baclofen injection) may be additive to those of alcohol and other CNS depressants.

Intrathecal mass: Cases of intrathecal mass at the tip of the implanted catheter have been reported, most of them involving pharmacy compounded analgesic admixtures. The most frequent symptoms associated with intrathecal mass are: 1) decreased therapeutic response (worsening spasticity, return of spasticity when previously well controlled, withdrawal symptoms, poor response to escalating doses, or frequent or large dosage increases), 2) pain, 3) neurological deficit/dysfunction. Clinicians should monitor patients on intraspinal therapy carefully for any new neurological signs or symptoms. In patients with new neurological signs or symptoms suggestive of an intrathecal mass, consider a neurosurgical consultation, since many of the symptoms of inflammatory mass are not unlike the symptoms experienced by patients with severe spasticity from their disease. In some cases, performance of an imaging procedure may be appropriate to confirm or rule-out the diagnosis of an intrathecal mass.

Precautions in special patient populations: Careful dose titration of Lioresal Intrathecal is needed when spasticity is necessary to sustain upright posture and balance in locomotion or whenever spasticity is used to obtain optimal function and care.

Patients suffering from psychotic disorders, schizophrenia, or confusional states should be treated cautiously with Lioresal Intrathecal and kept under careful surveillance, because exacerbations of these conditions have been observed with oral administration.

Lioresal Intrathecal should be used with caution in patients with a history of autonomic dysreflexia. The presence of nociceptive stimuli or abrupt withdrawal of Lioresal Intrathecal (baclofen injection) may cause an autonomic dysreflexic episode.

Because LIORESAL is primarily excreted unchanged by the kidneys, it should be given with caution in patients with impaired renal function and it may be necessary to reduce the dosage.

LABORATORY TESTS

No specific laboratory tests are deemed essential for the management of patients on Lioresal Intrathecal.

DRUG INTERACTIONS

There is inadequate systematic experience with the use of Lioresal Intrathecal in combination with other medications to predict specific drug-drug interactions. Interactions attributed to the combined use of LIORESAL INTRATHECAL and epidural morphine include hypotension and dyspnea.

CARCINOGENESIS, MUTAGENESIS, AND IMPAIRMENT OF FERTILITY

No increase in tumors was seen in rats receiving LIORESAL (baclofen USP) orally for two years at approximately 30-60 times on a mg/kg basis, or 10-20 times on a mg/m 2 basis, the maximum oral dose recommended for human use. Mutagenicity assays with LIORESAL have not been performed.

PREGNANCY CATEGORY C

LIORESAL (baclofen USP) given orally has been shown to increase the incidence of omphaloceles (ventral hernias) in fetuses of rats given approximately 13 times on a mg/kg basis, or 3 times on a mg/m 2 basis, the maximum oral dose recommended for human use; this dose also caused reductions in food intake and weight gain in the dams.

This abnormality was not seen in mice or rabbits. There are no adequate and well-controlled studies in pregnant women. LIORESAL should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

NURSING MOTHERS

In mothers treated with oral LIORESAL (baclofen USP) in therapeutic doses, the active substance passes into the breast milk. It is not known whether detectable levels of drug are present in breast milk of nursing mothers receiving LIORESAL INTRATHECAL. As a general rule, nursing should be undertaken while a patient is receiving Lioresal Intrathecal only if the potential benefit justifies the potential risks to the infant.

PEDIATRIC USE

Children should be of sufficient body mass to accommodate the implantable pump for chronic infusion. Please consult pump manufacturer's manual for specific recommendations.

Safety and effectiveness in pediatric patients below the age of 4 have not been established. Considerations based on experience with oral LIORESAL (baclofen USP)

A dose-related increase in incidence of ovarian cysts was observed in female rats treated chronically with oral LIORESAL. Ovarian cysts have been found by palpation in about 4% of the multiple sclerosis patients who were treated with oral LIORESAL for up to one year. In most cases these cysts disappeared spontaneously while patients continued to receive the drug. Ovarian cysts are estimated to occur spontaneously in approximately 1% to 5% of the normal female population.

ADVERSE DRUG EVENTS

Spasticity of Spinal Cord Origin:

Commonly Observed in Patients with Spasticity of Spinal Origin — In pre - and post-marketing clinical trials, the most commonly observed adverse events associated with use of Lioresal Intrathecal (baclofen injection) which were not seen at an equivalent incidence among placebo-treated patients were: somnolence, dizziness, nausea, hypotension, headache, convulsions and hypotonia.

Associated with Discontinuation of Treatment — 8/474 patients with spasticity of spinal cord origin receiving long term infusion of Lioresal Intrathecal in pre - and post-marketing clinical studies in the U. S. discontinued treatment due to adverse events. These include: pump pocket infections (3), meningitis (2), wound dehiscence (1), gynecological fibroids (1) and pump overpressurization (1) with unknown, if any, sequela. Eleven patients who developed coma secondary to overdose had their treatment temporarily suspended, but all were subsequently re-started and were not, therefore, considered to be true discontinuations.

Fatalities — See Warnings.

Incidence in Controlled Trials — Experience with Lioresal Intrathecal (baclofen injection) obtained in parallel, placebo-controlled, randomized studies provides only a limited basis for estimating the incidence of adverse events because the studies were of very brief duration (up to three days of infusion) and involved only a total of 63 patients. The following events occurred among the 31 patients receiving LIORESAL INTRATHECAL (baclofen injection) in two randomized, placebo-controlled trials: hypotension (2), dizziness (2), headache (2), dyspnea (1). No adverse events were reported among the 32 patients receiving placebo in these studies.

Events Observed during the Pre - and Post-marketing Evaluation of Lioresal Intrathecal — Adverse events associated with the use of Lioresal Intrathecal reflect experience gained with 576 patients followed prospectively in the United States. They received Lioresal Intrathecal for periods of one day (screening) (N = 576) to over eight years (maintenance) (N = 10). The usual screening bolus dose administered prior to pump implantation in these studies was typically 50 mcg. The maintenance dose ranged from 12 mcg to 2003 mcg per day. Because of the open, uncontrolled nature of the experience, a causal linkage between events observed and the administration of LIORESAL INTRATHECAL cannot be reliably assessed in many cases and many of the adverse events reported are known to occur in association with the underlying conditions being treated. Nonetheless, many of the more commonly reported reactions—hypotonia, somnolence, dizziness, paresthesia, nausea/vomiting and headache—appear clearly drug-related.

Adverse experiences reported during all U. S. studies (both controlled and uncontrolled) are shown in the following table. Eight of 474 patients who received chronic infusion via implanted pumps had adverse experiences which led to a discontinuation of long term treatment in the pre - and post-marketing studies.

INCIDENCE OF MOST FREQUENT (≥1%) ADVERSE EVENTS IN PATIENTS WITH SPASTICITY OF SPINAL ORIGIN IN PROSPECTIVELY MONITORED CLINICAL TRIALS

Percent of Patients Reporting Events

In addition to the more common (1% or more) adverse events reported in the prospectively followed 576 domestic patients in pre - and post-marketing studies, experience from an additional 194 patients exposed to LIORESAL INTRATHECAL (baclofen injection) from foreign studies has been reported. The following adverse events, not described in the table, and arranged in decreasing order of frequency, and classified by body system, were reported:

Nervous System: Abnormal gait, thinking abnormal, tremor, amnesia, twitching, vasodilitation, cerebrovascular accident, nystagmus, personality disorder, psychotic depression, cerebral ischemia, emotional lability, euphoria, hypertonia, ileus, drug dependence, incoordination, paranoid reaction and ptosis.

Digestive System: Flatulence, dysphagia, dyspepsia and gastroenteritis.

Cardiovascular: Postural hypotension, bradycardia, palpitations, syncope, arrhythmia ventricular, deep thrombophlebitis, pallor and tachycardia.

Respiratory: Respiratory disorder, aspiration pneumonia, hyperventilation, pulmonary embolus and rhinitis.

Urogenital: Hematuria and kidney failure.

Skin and Appendages: Alopecia and sweating.

Metabolic and Nutritional Disorders: Weight loss, albuminuria, dehydration and hyperglycemia.

Special Senses: Abnormal vision, abnormality of accommodation, photophobia, taste loss and tinnitus.

Body as a Whole: Suicide, lack of drug effect, abdominal pain, hypothermia, neck rigidity, chest pain, chills, face edema, flu syndrome and overdose.

Hemic and Lymphatic System: Anemia.

Spasticity of Cerebral Origin:

Commonly Observed — In pre-marketing clinical trials, the most commonly observed adverse events associated with use of Lioresal Intrathecal (baclofen injection) which were not seen at an equivalent incidence among placebo-treated patients included: agitation, constipation, somnolence, leukocytosis, chills, urinary retention and hypotonia.

Associated with Discontinuation of Treatment — Nine of 211 patients receiving Lioresal Intrathecal in pre-marketing clinical studies in the U. S. discontinued long term infusion due to adverse events associated with intrathecal therapy.

The nine adverse events leading to discontinuation were: infection (3), CSF leaks (2), meningitis (2), drainage (1), and unmanageable trunk control (1).

Fatalities — Three deaths, none of which were attributed to Lioresal Intrathecal, were reported in patients in clinical trials involving patients with spasticity of cerebral origin. See Warnings on other deaths reported in spinal spasticity patients.

Incidence in Controlled Trials — Experience with Lioresal Intrathecal (baclofen injection) obtained in parallel, placebo-controlled, randomized studies provides only a limited basis for estimating the incidence of adverse events because the studies involved a total of 62 patients exposed to a single 50 mcg intrathecal bolus. The following events occurred among the 62 patients receiving Lioresal Intrathecal in two randomized, placebo-controlled trials involving cerebral palsy and head injury patients, respectively: agitation, constipation, somnolence, leukocytosis, nausea, vomiting, nystagmus, chills, urinary retention, and hypotonia.

Events Observed during the Pre-marketing Evaluation of Lioresal Intrathecal — Adverse events associated with the use of LIORESAL INTRATHECAL reflect experience gained with a total of 211 U. S. patients with spasticity of cerebral origin, of whom 112 were pediatric patients (under age 16 at enrollment). They received Lioresal Intrathecal for periods of one day (screening) (N=211) to 84 months (maintenance) (N=1). The usual screening bolus dose administered prior to pump implantation in these studies was 50-75 mcg. The maintenance dose ranged from 22 mcg to 1400 mcg per day. Doses used in this patient population for long term infusion are generally lower than those required for patients with spasticity of spinal cord origin.

Because of the open, uncontrolled nature of the experience, a causal linkage between events observed and the administration of Lioresal Intrathecal cannot be reliably assessed in many cases. Nonetheless, many of the more commonly reported reactions—somnolence, dizziness, headache, nausea, hypotension, hypotonia and coma—appear clearly drug-related.

The most frequent (≥1%) adverse events reported during all clinical trials are shown in the following table. Nine patients discontinued long term treatment due to adverse events.

INCIDENCE OF MOST FREQUENT (≥ 1%) ADVERSE EVENTS IN PATIENTS WITH SPASTICITY OF CEREBRAL ORIGIN IN PROSPECTIVELY MONITORED CLINICAL TRIALS

Percent of Patients Reporting Events

The more common (1% or more) adverse events reported in the prospectively followed 211 patients exposed to Lioresal Intrathecal (baclofen injection) have been reported. In the total cohort, the following adverse events, not described in the table, and arranged in decreasing order of frequency, and classified by body system, were reported:

Nervous System: Akathisia, ataxia, confusion, depression, opisthotonos, amnesia, anxiety, hallucinations, hysteria, insomnia, nystagmus, personality disorder, reflexes decreased, and vasodilitation.

Digestive System: Dysphagia, fecal incontinence, gastrointestinal hemorrhage and tongue disorder.

Respiratory: Apnea, dyspnea and hyperventilation.

Urogenital: Abnormal ejaculation, kidney calculus, oliguria and vaginitis.

Skin and Appendages: Rash, sweating, alopecia, contact dermatitis and skin ulcer.

Special Senses: Abnormality of accommodation.

Body as a Whole: Death, fever, abdominal pain, carcinoma, malaise and hypothermia.

Hemic and Lymphatic System: Leukocytosis and petechial rash.

DRUG OVERDOSE

Special attention must be given to recognizing the signs and symptoms of overdosage, especially during the initial screening and dose-titration phase of treatment, but also during reintroduction of Lioresal Intrathecal after a period of interruption in therapy.

Symptoms of Lioresal Intrathecal Overdose: Drowsiness, lightheadedness, dizziness, somnolence, respiratory depression, hypothermia, seizures, rostral progression of hypotonia and loss of consciousness progressing to coma of up to 72 hr. duration. In most cases reported, coma was reversible without sequelae after drug was discontinued. Symptoms of Lioresal Intrathecal overdose were reported in a sensitive adult patient after receiving a 25 mcg intrathecal bolus.

Treatment Suggestions for Overdose:

There is no specific antidote for treating overdoses of LIORESAL INTRATHECAL (baclofen injection); however, the following steps should ordinarily be undertaken:

Residual Lioresal Intrathecal solution should be removed from the pump as soon as possible.

Patients with respiratory depression should be intubated if necessary, until the drug is eliminated.

If lumbar puncture is not contraindicated, consideration should be given to withdrawing 30-40 mL of CSF to reduce CSF baclofen concentration.

Lioresal Intrathecal Dosage and Administration

Refer to the manufacturer's manual for the implantable pump approved for intrathecal infusion for specific instructions and precautions for programming the pump and/or refilling the reservoir. There are various pumps with varying reservoir volumes and there are various refill kits available. It is important to be familiar with all of these products in order to select the appropriate refill kit for the particular pump in use.

Screening Phase: Prior to pump implantation and initiation of chronic infusion of LIORESAL INTRATHECAL (baclofen injection), patients must demonstrate a positive clinical response to a Lioresal Intrathecal bolus dose administered intrathecally in a screening trial. The screening trial employs Lioresal Intrathecal at a concentration of 50 mcg/mL. A 1 mL ampule (50 mcg/mL) is available for use in the screening trial. The screening procedure is as follows. An initial bolus containing 50 micrograms in a volume of 1 milliliter is administered into the intrathecal space by barbotage over a period of not less than one minute. The patient is observed over the ensuing 4 to 8 hours. A positive response consists of a significant decrease in muscle tone and/or frequency and/or severity of spasms. If the initial response is less than desired, a second bolus injection may be administered 24 hours after the first. The second screening bolus dose consists of 75 micrograms in 1.5 milliliters. Again, the patient should be observed for an interval of 4 to 8 hours. If the response is still inadequate, a final bolus screening dose of 100 micrograms in 2 milliliters may be administered 24 hours later.

Pediatric Patients: The starting screening dose for pediatric patients is the same as in adult patients, i. e. 50 mcg. However, for very small patients, a screening dose of 25 mcg may be tried first. Patients who do not respond to a 100 mcg intrathecal bolus should not be considered candidates for an implanted pump for chronic infusion.

Post-Implant Dose Titration Period: To determine the initial total daily dose of Lioresal Intrathecal following implant, the screening dose that gave a positive effect should be doubled and administered over a 24-hour period, unless the efficacy of the bolus dose was maintained for more than 8 hours, in which case the starting daily dose should be the screening dose delivered over a 24-hour period. No dose increases should be given in the first 24 hours (i. e. until the steady state is achieved).

Adult Patients with Spasticity of Spinal Cord Origin: After the first 24 hours, for adult patients, the daily dosage should be increased slowly by 10-30% increments and only once every 24 hours, until the desired clinical effect is achieved.

Adult Patients with Spasticity of Cerebral Origin: After the first 24 hours, the daily dose should be increased slowly by 5-15% only once every 24 hours, until the desired clinical effect is achieved.

Pediatric Patients: After the first 24 hours, the daily dose should be increased slowly by 5-15% only once every 24 hours, until the desired clinical effect is achieved. If there is not a substantive clinical response to increases in the daily dose, check for proper pump function and catheter patency. Patients must be monitored closely in a fully equipped and staffed environment during the screening phase and dose-titration period immediately following implant. Resuscitative equipment should be immediately available for use in case of life-threatening or intolerable side effects.

Maintenance Therapy:

Spasticity of Spinal Cord Origin Patients: The clinical goal is to maintain muscle tone as close to normal as possible, and to minimize the frequency and severity of spasms to the extent possible, without inducing intolerable side effects. Very often, the maintenance dose needs to be adjusted during the first few months of therapy while patients adjust to changes in life style due to the alleviation of spasticity. During periodic refills of the pump, the daily dose may be increased by 10-40%, but no more than 40%, to maintain adequate symptom control. The daily dose may be reduced by 10-20% if patients experience side effects. Most patients require gradual increases in dose over time to maintain optimal response during chronic therapy. A sudden large requirement for dose escalation suggests a catheter complication (i. e. catheter kink or dislodgement).

Maintenance dosage for long term continuous infusion of Lioresal Intrathecal (baclofen injection) has ranged from 12 mcg/day to 2003 mcg/day, with most patients adequately maintained on 300 micrograms to 800 micrograms per day. There is limited experience with daily doses greater than 1000 mcg/day. Determination of the optimal Lioresal Intrathecal dose requires individual titration. The lowest dose with an optimal response should be used.

Spasticity of Cerebral Origin Patients: The clinical goal is to maintain muscle tone as close to normal as possible and to minimize the frequency and severity of spasms to the extent possible, without inducing intolerable side effects, or to titrate the dose to the desired degree of muscle tone for optimal functions. Very often the maintenance dose needs to be adjusted during the first few months of therapy while patients adjust to changes in life style due to the alleviation of spasticity. During periodic refills of the pump, the daily dose may be increased by 5-20%, but no more than 20%, to maintain adequate symptom control. The daily dose may be reduced by 10-20% if patients experience side effects. Many patients require gradual increases in dose over time to maintain optimal response during chronic therapy. A sudden large requirement for dose escalation suggests a catheter complication (i. e. catheter kink or dislodgement).

Maintenance dosage for long term continuous infusion of Lioresal Intrathecal (baclofen injection) has ranged from 22 mcg/day to 1400 mcg/day, with most patients adequately maintained on 90 micrograms to 703 micrograms per day. In clinical trials, only 3 of 150 patients required daily doses greater than 1000 mcg/day.

Pediatric Patients: Use same dosing recommendations for patients with spasticity of cerebral origin. Pediatric patients under 12 years seemed to require a lower daily dose in clinical trials. Average daily dose for patients under 12 years was 274 mcg/day, with a range of 24 to 1199 mcg/day. Dosage requirement for pediatric patients over 12 years does not seem to be different from that of adult patients. Determination of the optimal Lioresal Intrathecal dose requires individual titration. The lowest dose with an optimal response should be used.

Potential need for dose adjustments in chronic use. During long term treatment, approximately 5% (28/627) of patients become refractory to increasing doses. There is not sufficient experience to make firm recommendations for tolerance treatment; however, this “tolerance” has been treated on occasion, in hospital, by a “drug holiday” consisting of the gradual reduction of Lioresal Intrathecal over a 2 to 4 week period and switching to alternative methods of spasticity management. After the “drug holiday,” LIORESAL INTRATHECAL may be restarted at the initial continuous infusion dose.

Stability

Parenteral drug products should be inspected for particulate matter and discoloration prior to administration, whenever solution and container permit.

Delivery Specifications

The specific concentration that should be used depends upon the total daily dose required as well as the delivery rate of the pump. LIORESAL INTRATHECAL may require dilution when used with certain implantable pumps. Please consult manufacturer's manual for specific recommendations.

Preparation Instruction:

Use the 1 mL screening ampule only (50 mcg/mL) for bolus injection into the subarachnoid space. For a 50 mcg bolus dose, use 1 mL of the screening ampule. Use 1.5 mL of 50 mcg/mL baclofen injection for a 75 mcg bolus dose. For the maximum screening dose of 100 mcg, use 2 mL of 50 mcg/mL baclofen injection (2 screening ampules).

For patients who require concentrations other than 500 mcg/mL or 2000 mcg/mL, Lioresal Intrathecal must be diluted.

Lioresal Intrathecal must be diluted with sterile preservative free Sodium Chloride for Injection, U. S.P.

Delivery Regimen:

Lioresal Intrathecal is most often administered in a continuous infusion mode immediately following implant. For those patients implanted with programmable pumps who have achieved relatively satisfactory control on continuous infusion, further benefit may be attained using more complex schedules of LIORESAL INTRATHECAL delivery. For example, patients who have increased spasms at night may require a 20% increase in their hourly infusion rate. Changes in flow rate should be programmed to start two hours before the time of desired clinical effect.

How is Lioresal Intrathecal Supplied

Lioresal Intrathecal (baclofen injection) is packaged in single use ampules containing 0.05 mg/1 mL (50 mcg/mL), 10 mg/20 mL (500 mcg/mL), 10 mg/5 mL (2000 mcg/mL), or 40 mg/20 mL (2000 mcg/mL) supplied as follows:

Screening dose (Model 8563s): one ampule containing 0.05 mg/1 mL (50 mcg/mL) (NDC 58281-562-01).

Lioresal Intrathecal (baclofen injection) Refill Kits. Each refill kit includes the indicated amount of Lioresal Intrathecal, a drug preparation kit, a pump refill kit with accessories that are compatible with Medtronic SynchroMed® Infusion Systems, and associated instructions.

Model 8561: one ampule containing 10 mg/20 mL (500 mcg/mL) (NDC 58281-560-01).

Model 8562: two ampules, each contains 10 mg/5 mL (2000 mcg/mL) (NDC 58281-561-02).

Model 8564: one ampule containing 40 mg/20 mL (2000 mcg/mL) (NDC 58281-563-01).

Model 8565: two ampules, each contains 10 mg/20 mL (500 mcg/mL) (NDC 58281-560-02).

Model 8566: two ampules, each contains 40 mg/20 mL (2000 mcg/mL) (NDC 58281-563-02).

STORAGE

Does not require refrigeration.

Do not store above 86°F (30°C).

Do not heat sterilize.

Manufactured by Novartis Pharma Stein AG, Stein, Switzerland, for Medtronic, Inc. Minneapolis, Minnesota 55432-5604 USA.

Lioresal ® and SynchroMed® are registered trademarks of Medtronic, Inc.

Medtronic, Inc. 710 Medtronic Parkway NE Minneapolis, MN 55432-5604 USA www. medtronic. com Tel. 763-505-5000 Toll-free 1-800-328-0810 Fax 763-505-1000

Refill Kit 856X for use with Medtronic Implantable Programmable Infusion Pumps

Instructions for Use

Explanation of symbols on product or package labeling

Refer to the appropriate product for symbols that apply.

Medtronic ®. Lioresal ®. lsoMed ®. SynchroMed ®. and MiniMed ® are trademarks of

Medtronic, registered in the U. S.

Table of contents

Instructions for use Sterilization Preliminary procedures Emptying the SynchroMed pump Refilling the SynchroMed pump Programming the SynchroMed pump After the refill procedure

Emergency procedures Lioresal Intrathecal (baclofen injection) overdose Lioresal Intrathecal (baclofen injection) underdose/withdrawal Emergency procedure to empty pump reservoir

Limited Warranty Medtronic® Neuromodulation MODEL 856X REFILL KIT LIMITED WARRANTY

Refer to the Indications, Drug Stability, and Emergency Procedures reference manual for indications and related information.

Refer to the appropriate information for prescribers booklet for contraindications, warnings, precautions, adverse events summary, individualization of treatment, patient selection, use in specific populations, and component disposal.

Refer to the Lioresal Intrathecal (baclofen injection) drug labeling for indications, contraindications, warnings, precautions, dosage and administration information, and screening procedures.

Introduction

These instructions include only the procedure for refilling the pump reservoir with Lioresal Intrathecal (baclofen injection). Refer to the appropriate pump technical manual for implanting instructions.

Package contents

The Model 856X Refill Kit contains the following sterile components that are not made with natural rubber latex:

20-mL syringe

Extension set with a clamp

Template

0.22-micron filter

Two 22-gauge noncoring needles

Fenestrated drape

Accessories (povidone iodine swabs, gauze pads, alcohol pads, gloves)

Indications

The Model 856X Refill Kit is intended for use in refilling Medtronic implantable programmable infusion pumps with the exception of Medtronic MiniMed infusion pumps.

Contraindications

Medtronic refill kits are contraindicated for all catheter access port procedures.

Warnings

Withdrawal - Abrupt discontinuation of intrathecal baclofen, regardless of the cause, has resulted in sequelae that include high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, that in rare cases has advanced to rhabdomyolysis, multiple organ-system failure and death.

Prevention of abrupt discontinuation of intrathecal baclofen requires careful attention to programming and monitoring of the infusion system, refill scheduling and procedures, and pump alarms. Patients and caregivers should be advised of the importance of keeping scheduled refill visits and should be educated on the early symptoms of baclofen withdrawal. Special attention should be given to patients at apparent risk (e. g. spinal cord injuries at T-6 or above, communication difficulties, history of withdrawal symptoms from oral or intrathecal baclofen). Consult the technical manual of the implantable infusion system for additional postimplant clinician and patient information.

User instructions - Comply with all product instructions for initial preparation and filling, implantation, programming, refilling, and accessing the catheter access port (if present) of the pump. Failure to comply with all instructions can lead to technical errors or improper use of implanted infusion pumps and result in additional surgical procedures, a return of underlying symptoms, drug withdrawal symptoms, or a clinically significant or fatal drug underdose or overdose.

Implantation and system management - Implantation and ongoing system management must be performed by individuals trained in the operation and handling of the infusion system and must be in compliance with procedures described in the appropriate technical instructions. Inadequate training or failure to follow instructions can require surgical revision or replacement, and result in a clinically significant or fatal drug underdose or overdose.

Calculating catheter volume - Use the catheter length recorded at implant or catheter revision when calculating catheter volume. The actual implanted catheter length and catheter model number are required to accurately calculate catheter volume. A universal value does not exist that can be used as a substitute for this knowledge. An inaccurate catheter volume calculation can result in a clinically significant or fatal drug underdose or overdose.

Contrast medium (pumps with a catheter access port) - Do not inject any contrast medium into the pump reservoir. Injecting contrast medium into the pump reservoir can impair pump operation.

Refill - Patients must return to the clinic for refills at the prescribed times. Failure to return to the clinic for refills at the prescribed times can result in the actual flow rate of the pump being less than expected, resulting in a loss of or change in therapy, which may lead to a return of underlying symptoms, drug withdrawal symptoms, or a clinically significant or fatal drug underdose. Failure to return at the prescribed times can also damage the pump, requiring surgical replacement.

Refill kit components – Use the appropriate Medtronic refill kit during all refill procedures for Medtronic implantable infusion pumps. Using components other than Medtronic components or a kit other than the appropriate refill kit can damage Medtronic components, requiring surgical revision or replacement, and allow drug leakage into surrounding tissue, resulting in loss of or change in therapy, which may lead to a return of underlying symptoms, drug withdrawal symptoms, or a clinically significant or fatal drug underdose or overdose.

Injection error during a pump refill procedure - Be certain you are accessing the reservoir fill port when injecting fluids into an implanted pump. ALWAYS:

identify the pump model and reservoir volume.

identify the location of the reservoir fill port. - Avoid pocket fill, i. e. improper injection of medication into the subcutaneous tissue (see below) - Avoid inadvertent injection into the catheter access port (see below)

use the instructions, noncoring needles, appropriate template edge, and other accessories provided in the appropriate kit.

verify the location of the reservoir fill port during needle insertion according to the instructions provided AND using other medical procedures as appropriate.

refer to the drug labeling for indications, contraindications, warnings, precautions, adverse events, and dosage and administration information.

Pocket fill is the improper injection of refill medication into the subcutaneous tissue, which includes the pump pocket. The injection of drug into the subcutaneous tissue can lead to an acute systemic overdose, which can be fatal. After a pocket fill, the pump reservoir will become empty sooner than anticipated, and this may cause underdose symptoms and/or baclofen withdrawal syndrome, which can be fatal. If it is suspected or known that all or part of the drug was injected into the pocket during the refill procedure, monitor the patient closely for signs and symptoms of overdose in an appropriate facility for a sufficient amount of time or until the symptoms have resolved. Refer to the refill kit manual or the Indications, Drug Stability, and Emergency Procedures for SynchroMed and IsoMed Implantable Infusion Systems Reference Manual for emergency procedures associated with drug underdose and overdose. Refer to the drug product information label for specific drug underdose and overdose symptoms and methods of management.

Inadvertent injection into the catheter access port may result in a clinically significant or fatal drug overdose. If it is suspected or known that all or part of the drug was injected into the catheter access port during the refill procedure, monitor the patient closely for signs and symptoms of overdose in an appropriate facility for a sufficient amount of time or until the symptoms have resolved. Refer to the catheter access port kit manual or the Indications, Drug Stability, and Emergency Procedures for SynchroMed and IsoMed Implantable Infusion Systems Reference Manual for emergency procedures associated with drug and overdose. Refer to the drug labeling for specific drug overdose symptoms and methods of management.

Changing drug or decreasing drug concentrations - Rinse the reservoir twice between solutions when changing drug or decreasing drug concentrations in the pump reservoir. A significant amount of drug may be present in the pump reservoir after emptying the pump. This residual volume cannot be removed by emptying the pump. Rinsing the reservoir between solutions minimizes the amount of drug in this residual volume but does not eliminate it. Failure to account for residual drug in the pump reservoir can result in a concentration that is different than intended and a clinically significant or fatal drug underdose or overdose. Program a bridge bolus after rinsing the reservoir twice. The bridge bolus advances the remaining old drug (the drug left in the pump tubing, catheter access port, and catheter after emptying and refilling the pump) to the catheter tip at the prior flow rate.

Refer to "Performing a reservoir rinse" on page 18 of this manual. Refer to the programming guide for bridge bolus procedures.

Connections - Firmly secure all connections. Failure to secure connections can allow drug to leak onto the surrounding skin and may result in inadequate therapy or infection.

Reservoir fill port injections - Do not use excessive force when accessing the reservoir fill port. Excessive force can result in damage to the needle or pump requiring surgical revision or replacement, and leakage into surrounding tissue, resulting in loss of or change in therapy, which may lead to a return of underlying symptoms, drug withdrawal symptoms, or a clinically significant or fatal drug underdose or overdose.

Intrathecal therapy - For intrathecal therapy, use ONLY a preservative-free sterile solution indicated for intrathecal use. Nonindicated fluids containing preservatives or endotoxins can be neurotoxic in intrathecal applications. Using nonindicated fluids can result in adverse events including, but not limited to, extreme pain, cramps, seizures, and death.

Drug information - Refer to the drug labeling for indications, contraindications, warnings, precautions, dosage and administration information, and screening procedures. Refer to the drug labeling for specific drug underdose or overdose symptoms and methods of management. Failure to refer to the drug labeling can result in inappropriate patient selection and management, inadequate therapy, intolerable side effects, or a clinically significant or fatal drug underdose or overdose. Consider the possibility of a drug error if the patient experiences unusual side effects. Failure to do so can result in misdiagnosis of patient symptoms.

Mixing drugs - The effects that drug mixtures have on pump operation are unknown. Drugs can precipitate when mixed. These precipitates can inhibit pump flow or block the catheter, resulting in loss of therapy or a clinically significant or fatal drug underdose.

Drug interaction and side effects - Inform patients of the appropriate warnings and precautions regarding drug interactions, potential side effects, and signs and symptoms that require medical attention, including prodromal signs and symptoms of inflammatory mass. Failure to recognize the signs and symptoms and to seek appropriate medical intervention can result in serious patient injury or death.

Drug overdose symptoms and management - Refer to the emergency procedures included at the end of this manual and the drug labeling for specific drug overdose symptoms and methods of management.

Drug underdose/overdose - Inform patients and caregivers of the signs and symptoms of a drug underdose and overdose. Inform patients and caregivers:

to be aware and report any unusual signs or symptoms at anytime during or after a refill or catheter access port procedure.

to be alert for any burning sensations in the area of the pump pocket during their refill or catheter access port procedure.

to especially watch for signs of underdose and overdose.

to stay alert for signs or symptoms that may indicate changes to their prescribed drug concentration or programmed dose.

to seek emergency assistance as necessary. Refer to the refill kit or catheter access port kit manual or the Indications, Drug Stability and Emergency Procedures for SynchroMed and IsoMed Implantable Infusion Systems Reference Manual for emergency procedures associated with drug underdose and overdose.

Failure to recognize these signs and symptoms and to seek appropriate medical intervention can result in serious patient injury or death.

Patient travel - Patients should notify their clinicians of any travel plans. Clinicians need this information to coordinate patient care and pump refills and help prevent a loss of or change in therapy, which may lead to a return of underlying symptoms, drug withdrawal symptoms, or a clinically significant or fatal drug underdose.

Precautions

Compatibility, all components - Follow these guidelines when selecting system components:

Medtronic components: For proper therapy, use only components that are compatible with the appropriate indication.

Non-Medtronic components: No claims of safety, efficacy, or compatibility are made with regard to the use of non-Medtronic components with Medtronic components. Refer to the non-Medtronic documentation for information.

Component packaging - Before shipment the components in the sterile package were sterilized by the process indicated on the package label. Do not use or implant a component if the following circumstances have occurred:

The storage package or sterile seal has been pierced or altered because component sterility cannot be guaranteed and infection may occur.

The component shows signs of damage because the component may not function properly.

The use-by date has expired because component sterility cannot be guaranteed and infection may occur; also, device battery longevity may be reduced and may require early replacement.

Storage temperature: kits and accessories - Do not store or transport the kit device components or accessories above 57 °C (135 °F) or below –34 °C (–30 °F). Temperatures outside this range can damage device components.

Aseptic technique - Use strict aseptic technique when accessing the reservoir fill port or the catheter access port of an implanted pump. Failure to use aseptic technique can contaminate fluids or tissues and result in local or systemic infection.

Infection - Use extreme caution when accessing the reservoir fill port or catheter access port of the implanted pump if local or systemic infection is suspected. Avoid contaminating the system or further spreading the infection. Local or systemic infection may require pump revision or removal.

Therapy discontinuance - If therapy is discontinued for an extended period, fill the pump reservoir with preservative-free saline. Program the pump to infuse at the minimum flow rate. Refill the pump as needed to ensure the pump always contains fluid in the reservoir and fluid pathway. Stopping the pump for extended periods or allowing the pump reservoir to empty completely can damage the system and require surgical replacement.

Single use only - Do not reuse any component. Components are intended for single use only. Reusing components can result in inadequate therapy and an increased risk of infection.

Reservoir valve activation - Do not prematurely activate the pump reservoir valve. Activation of the pump reservoir valve seals the pump reservoir valve closed. Unusual resistance or the inability to inject the entire fill volume may indicate activation of the pump reservoir valve. If the valve closes, a portion of the reservoir contents must be delivered or removed before filling can be completed, and procedural delays can occur. To prevent activation of the pump reservoir valve during emptying and filling procedures:

completely aspirate all contents of the pump reservoir before filling;

do not allow air into the pump reservoir through an open needle in the septum or an unclamped extension; and

do not exceed the maximum reservoir volume indicated in the pump labeling.

Adverse events

The adverse events associated with the use of this device may include, but may not be limited to, the following:

Meningitis

Infection

Reservoir contamination

Overpressurization of the reservoir

Injection into pocket or subcutaneous tissue

Activation of reservoir valve

Instructions for use

Become thoroughly familiar with all product literature before using this refill kit.

All components of the kit are sterile. Do not resterilize. Should sterility of the kit be in question, discard and use a new kit.

Preliminary procedures

Gather the following sterile equipment:

Syringe(s) containing prescribed fluid

From the refill kit:

20-mL empty syringe

Extension set with a clamp

Template

0.22-micron filter

22-gauge noncoring needle

Fenestrated drape

Cleansing agent

Alcohol pads

Sterile gloves (not made with natural rubber latex)

Locally supplied:

Adhesive bandage, optional

Refer to the drug labeling for indications, contraindications, warnings, precautions, dosage and administration information, and screening procedures.

Prepare the programmer for use. Refer to the appropriate programming guide for instructions.

Confirm the:

pump model

reservoir volume

location of the pump

Note: The model and reservoir volume can be confirmed by the programmer. Alternatively, a radiopaque identifier in the pump shows the pump model and identifies Medtronic as the pump manufacturer on a standard x-ray (Figure 1). A three-letter code designates the pump model.

Figure 1. A radiopaque identifier on a SynchroMed II pump.

Confirm that the volume of the prescribed fluid does not exceed the reservoir volume of the pump.

Emptying the SynchroMed pump

Prepare the

Fouch, Fouch

Michele Perrin says:

I can tell you that the description of how Perrin’s Landing came to be named is inaccurate, since it was my own grandparents who created Perrin’s Landing. My grandfather, Earl Perrin, owned and operated Perrin’s Landing from the early 1930s until his death in the 1980s and was occupied by my Grandma, Dorothy Perrin, until she died in the 1990s. They had a lodge with a store, a stocked trout pond, many small cabins and campsites and boats for rent or charter. They even operated in winter as an ice-fishing desstination. My Aunt Cynthia Perrin Schroeder still lives in the area.

BJ Ingwersen says:

Got to this blog doing research for writing: story of my Father’s logging days in Leelanau. Am interested in learning more of Perrins landing as my Dad stayed i9n a cabin there, I believe with my Mom and two daughers in the late 40’s or very erly 50’s. Am trying to describe what it was like there (community, events)then. If Ms. Perrin has any more knowledge to share….?

John Lievense says:

Jerry Fouch says:

Kris fuller did you ever post that picture of the Hotel Wisteria? Michelle Perrin I’m sure we have talked or at least aknowledge one another on numerous occasions when I was a young boy. I spent many summerdays at the Fouch farm growing up and many of those days at Perrins Landing fishing, swimming or just raising cane. I remember on a couple of occasions your Grandpa would give us food to feed the fish. I believe they were brown trout, huge brown trout. Have you posted any pictures on the web? would love to hear from you. Jerry Fouch

Michele Perrin Gustafson says:

So great to see the posts from folks who loved Perrin’s Landing as I did! We spent summers there and those were some of my very besg memories! My dad was Richard (called Dick) and my uncle John was a real cutie. He lived with us for a while when I was a kid. My Aunts Julie and Cynthia were great. Cynthia Married PEte Schroeder, and she and Pete and their kids Shelley and Mike lived right at Perrin’s Landing, and may still (I am not in touch with them.). My Grandma Dorothy Perrin died making the left turn onto Fouch road in the 1990s. I wish I had pictures form those days but I have none at all. If anyone has any photos, I would be so grateful if you would e-mail them to me at perrin. michele@yahoo. com. Thanks, Michle

Dan Gehring says:

All I remember was Perrin’s Landing when I was a kid. Earl and Dorothy treated us like royality. Johnny and I were best of friends. I even remember Dan Perrin so you know how old I am. Usually came up with my grandparents, Ross and Norris Carey. We had a cousin across the lake. I have nothing but the best of memories at the landing. I still remember Earl tossing us up in the air about a hundred feet out in the lake. Johnny and I would siene minnow and gather worms for fishin. I have a couple of post card photos I could send. Sorry thats all I have. I would like you to know that Perrin’s Landing is one of my most remembered places in my life. I will never forget those days. We were from Noblesville, Indiana. Hope you get this. Dan Gehring

Michele Perrin Gustafson says:

Dan: Thanks for sharing. I guess Dan Perrin must have been Earl’s father. You might even remember my Great-Great Aunt Ida who lived to be over 100 and used to visit Perrin’s Landing often. You might also remember a pet black swan who used to terrorize us kids! I remember the trout pond and getting to feed the huge trout and the baby ducks that we often saw there. I learned to fish there, as it sounds like you probably did, too.

Do you remember how my Grandma Dorothy was always a bit hard of hearing? She would guess what she thought we said a lot of the time, with hysterical results sometimes. Anyway, thanks for bringing back the memories!

BJ Ingwersen says:

What a small world. I have not visited this blog since early last year. My Dad and Mom were good friends with Earl and Dorothy and lived at the landing for a short time in the late 40’s, I think. Last time I was on this blog, I was doing research for a story about my Dad. My wife and I ride by the landing often on our bicycles. Back in the 90’s, before I even knew my wife, she happened upon an accident scene at Perrin’s. and gave CPR(she’s a nurse)to Dorothy. I kind of remember the black swan, feeding the fish, and falling through the ice when I was small.

Mike Schroeder says:

My grandparents were Earl and Dorthy Perrin and as commented earlier, I grew up at the resort and still live just a few miles from it. Many of the posts from friends, guests and family, speak of memories generated from the wonderful times there. I feel very fortunate to have spent the best times of my life getting to know all these people and sharing in their vacation fun. Every day was a holiday. Pot-luck dinners on the beach, bonfires, fishing, swimming and even romancing made my childhood at Perrin’s Landing like a storybook character we know a Huck Finn. Thank you to all who shared it with my family and I.

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Buy Claropram - Citalopram - Online Without Prescriptions, Claropram

Celexa (Claropram)

Celexa is used for treating depression. Celexa is a selective serotonin reuptake inhibitor (SSRI). It works by restoring the balance of serotonin, a natural substance in the brain, which helps to improve certain mood problems.

Use Celexa as directed by your doctor.

Take Celexa by mouth with or without food.

Taking Celexa at the same time each day will help you remember to take it.

Continue to take Celexa even if you feel well. Do not miss any dose.

Do not suddenly stop taking Celexa without checking with your doctor. Side effects may occur. They may include mental or mood changes, numbness or tingling of the skin, dizziness, confusion, headache, trouble sleeping, or unusual tiredness.

If you miss a dose of Celexa, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Celexa.

Store Celexa at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Celexa out of the reach of children and away from pets.

Active Ingredient: Citalopram hydrobromide.

Do NOT use Celexa if:

you are allergic to any ingredient in Celexa

you are taking escitalopram

you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), selegiline, or St. John's wort within the last 14 days

you are taking a fenfluramine derivative (eg, dexfenfluramine), an H 1 antagonist (eg, astemizole, terfenadine), nefazodone, pimozide, or sibutramine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Celexa. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you or a family member has a history of bipolar disorder (manic-depression), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse

if you have a history of seizures, liver problems, severe kidney problems, stomach or bowel bleeding, or metabolism problems

if you are dehydrated, have low blood sodium levels, or drink alcohol

if you will be having electroconvulsive therapy (ECT).

Some medicines may interact with Celexa. Tell your health care provider if you are taking any other medicines, especially any of the following:

Fenfluramine derivatives (eg, dexfenfluramine), linezolid, lithium, MAOIs (eg, phenelzine), metoclopramide, nefazodone, selegiline, serotonin 5-HT 1 receptor agonists (eg, sumatriptan), sibutramine, St. John's wort, or trazodone because severe side effects, such as a reaction that may include fever, rigid muscles, blood pressure changes, mental changes, confusion, irritability, agitation, delirium, and coma, may occur

Anticoagulants (eg, warfarin), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of bleeding, including stomach bleeding, may be increased

Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood sodium levels may be increased

Tramadol because the risk of seizures may be increased

H 1 antagonists (eg, astemizole, terfenadine) or phenothiazines (eg, chlorpromazine, thioridazine) because severe heart problems, including irregular heartbeat, may occur

Carbamazepine or cyproheptadine because they may decrease Celexa's effectiveness

Clozapine, pimozide, risperidone, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Celexa.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Celexa may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Celexa may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Celexa with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol while you are using Celexa.

Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Celexa; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

One to 4 weeks may pass before your symptoms improve. Do NOT take more than the recommended dose, change your dose, or use Celexa for longer than prescribed without checking with your doctor.

Children, teenagers, and young adults who take Celexa may be at increased risk for suicidal thoughts or actions. Watch all patients who take Celexa closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Celexa and a medicine called escitalopram have the same active ingredient. Do not take Celexa if you are also taking escitalopram.

If your doctor tells you to stop taking Celexa, you will need to wait for several weeks before beginning to take certain other medicines (eg, MAOIs, nefazodone). Ask your doctor when you should start to take your new medicines after you have stopped taking Celexa.

Celexa may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.

Serotonin syndrome is a possibly fatal syndrome that can be caused by Celexa. Your risk may be greater if you take Celexa with certain other medicines (eg, "triptans," MAOIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.

Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Celexa. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.

Use Celexa with caution in the elderly; they may be more sensitive to its effects, especially low blood sodium levels.

Caution is advised when using Celexa in children; they may be more sensitive to its effects, especially increased risk of suicidal thoughts or actions.

Celexa should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Celexa may cause weight changes. Children and teenagers may need regular weight and growth checks while they take Celexa.

Pregnancy and breast-feeding: Celexa may cause harm to the fetus if it is used during the last 3 months of pregnancy. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Celexa while you are pregnant. Celexa is found in breast milk. Do not breastfeed while taking Celexa.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Decreased sexual desire or ability; diarrhea; dizziness; drowsiness; dry mouth; increased sweating; lightheadedness when you stand or sit up; loss of appetite; nausea; stuffy nose; tiredness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); absent menstrual period; bizarre behavior; black or bloody stools; chest pain; confusion; decreased concentration; decreased coordination; fainting; fast or irregular heartbeat; hallucinations; memory loss; new or worsening agitation, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, or inability to sit still; persistent, painful erection; red, swollen, blistered, or peeling skin; seizures; severe or persistent anxiety or trouble sleeping; severe or persistent headache; stomach pain; suicidal thoughts or attempts; tremor; unusual bruising or bleeding; unusual or severe mental or mood changes; unusual weakness; vision changes; worsening of depression.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Cetrivax, Cetrivax

Zyrtec (cetirizine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Zyrtec is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose.

Zyrtec is also used to treat itching and swelling caused by chronic urticaria (hives).

Zyrtec may also be used for purposes not listed in this medication guide.

Use Zyrtec exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

You may take Zyrtec with or without food.

The chewable tablet must be chewed before you swallow it.

Do not swallow the Zyrtec dissolving tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever. Store this medicine at room temperature away from moisture and heat. Do not allow the liquid form of this medicine to freeze.

Use Zyrtec exactly as directed on the label, or as prescribed by your doctor.

Ask your health care provider any questions you may have about how to use Zyrtec.

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Or store in the refrigerator between 36-46 degrees F (2-8 degrees C). Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Active ingredient: Cetirizine

Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide

Do NOT use Zyrtec if:

You are allergic to any ingredient in Zyrtec or to hydroxyzine Contact your doctor or health care provider right away if any of these apply to you. Some medical conditions may interact with Zyrtec. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, plan to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have kidney or liver problems, or are receiving dialysis

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zyrtec ; it may add to their effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have any medical conditions.

Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Zyrtec.

This list is not complete and other drugs may interact with Zyrtec. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Important safety information:

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

If you are scheduled for allergy testing, ask your doctor if you should stop taking this medication for several days before testing. This drug may affect your allergy test results.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and health care provider.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Zyrtec:

Drowsiness; dry mouth; stomach pain (in children); tiredness; trouble sleeping (in children).

Seek medical attention right away if any of these SEVERE side effects occur when using Zyrtec:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); dark urine; fainting; fast or irregular heartbeat; mental or mood changes; persistent fatigue; seizures; severe dizziness; unusual bruising or bleeding; yellowing of eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Zyrtec (cetirizine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Zyrtec is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose.

Zyrtec is also used to treat itching and swelling caused by chronic urticaria (hives).

Zyrtec may also be used for purposes not listed in this medication guide.

Use Zyrtec exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

You may take Zyrtec with or without food.

The chewable tablet must be chewed before you swallow it.

Do not swallow the Zyrtec dissolving tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever. Store this medicine at room temperature away from moisture and heat. Do not allow the liquid form of this medicine to freeze.

Use Zyrtec exactly as directed on the label, or as prescribed by your doctor.

Ask your health care provider any questions you may have about how to use Zyrtec.

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Or store in the refrigerator between 36-46 degrees F (2-8 degrees C). Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Active ingredient: Cetirizine

Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide

Do NOT use Zyrtec if:

You are allergic to any ingredient in Zyrtec or to hydroxyzine Contact your doctor or health care provider right away if any of these apply to you. Some medical conditions may interact with Zyrtec. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, plan to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have kidney or liver problems, or are receiving dialysis

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zyrtec ; it may add to their effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have any medical conditions.

Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Zyrtec.

This list is not complete and other drugs may interact with Zyrtec. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Important safety information:

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

If you are scheduled for allergy testing, ask your doctor if you should stop taking this medication for several days before testing. This drug may affect your allergy test results.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and health care provider.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Zyrtec:

Drowsiness; dry mouth; stomach pain (in children); tiredness; trouble sleeping (in children).

Seek medical attention right away if any of these SEVERE side effects occur when using Zyrtec:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); dark urine; fainting; fast or irregular heartbeat; mental or mood changes; persistent fatigue; seizures; severe dizziness; unusual bruising or bleeding; yellowing of eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Zyrtec (cetirizine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Zyrtec is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose.

Zyrtec is also used to treat itching and swelling caused by chronic urticaria (hives).

Zyrtec may also be used for purposes not listed in this medication guide.

Use Zyrtec exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

You may take Zyrtec with or without food.

The chewable tablet must be chewed before you swallow it.

Do not swallow the Zyrtec dissolving tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever. Store this medicine at room temperature away from moisture and heat. Do not allow the liquid form of this medicine to freeze.

Use Zyrtec exactly as directed on the label, or as prescribed by your doctor.

Ask your health care provider any questions you may have about how to use Zyrtec.

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Or store in the refrigerator between 36-46 degrees F (2-8 degrees C). Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Active ingredient: Cetirizine

Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide

Do NOT use Zyrtec if:

You are allergic to any ingredient in Zyrtec or to hydroxyzine Contact your doctor or health care provider right away if any of these apply to you. Some medical conditions may interact with Zyrtec. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, plan to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have kidney or liver problems, or are receiving dialysis

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zyrtec ; it may add to their effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have any medical conditions.

Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Zyrtec.

This list is not complete and other drugs may interact with Zyrtec. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Important safety information:

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

If you are scheduled for allergy testing, ask your doctor if you should stop taking this medication for several days before testing. This drug may affect your allergy test results.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and health care provider.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Zyrtec:

Drowsiness; dry mouth; stomach pain (in children); tiredness; trouble sleeping (in children).

Seek medical attention right away if any of these SEVERE side effects occur when using Zyrtec:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); dark urine; fainting; fast or irregular heartbeat; mental or mood changes; persistent fatigue; seizures; severe dizziness; unusual bruising or bleeding; yellowing of eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

28mm Napoleonics - Victrix Limited, Victrix

We now have 11 sets, VX0001 British Waterloo Centre companies, VX0002 British Peninsular Infantry Centre Companies, VX0003 Waterloo British Infantry Flank companies, VX0004 British Peninsular Infantry Flank Companies, VX0005 Napoleonic French Infantry 1807-1812, VX0006 British Napoleonic Highlander Centre Companies, VX0007 British Napoleonic Highlander Flank Companies, VX0008 French Napoleonic Infantry 1804 - 1807, VX0009 Napoleon's Old Guard Grenadiers, VX0010 British Napoleonic Foot Artillery and VX0011 Napoleon's Old Guard Chasseurs.

+ Main Menu

VX0019 French Napoleonic Artillery 1804-1812 XI System £24.95

VX0019 French Napoleonic Artillery 1804-1812 XI System

VX0019 French Napoleonic Artillery 1804-1812 XI system with 6pdr guns and howitzers. this will allow customers to field the later XI system with crew in pre bardin uniforms.

VX0018 28mm Napoleonic French Artillery 1812 to 1815 £19.96 - £24.95

VX0018 28mm Napoleonic French Artillery 1812 to 1815

The set contains 3 guns based on the XI system with options for 6 pounder or howitzer barrels. The set contains 15 crew with multiple arm options including shoulder straps.

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VX0017 28mm French Napoleonic Artillery 1804 to 1812 £19.96 - £24.95

VX0017 28mm French Napoleonic Artillery 1804 to 1812

This superb set of miniatures represents French foot artillery from 1804 to 1812. The set contains: A choice of 8pdr or 12 pdr guns for the Gribeauval system. 15 highly.

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Austrian Napoleonic Infantry 1798-1809 £18.36 - £22.95

Austrian Napoleonic Infantry 1798-1809

This set contains 56 Austrian Infantry figures. 2 x officers 2 x standard bearers 2 x Drummers 2 x mounted colonels 48 x infantry The officers and Mounted colonels have.

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Napoleon's French Old Guard Grenadiers £18.36 - £22.95

Napoleon's French Old Guard Grenadiers

The set contains 60 figures and fast play rules, also included are 8 regimental flags, representing flags of the 1811 and 1812 issue. Positions included in the box are: 4.

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Napoleon's French Middle Imperial Guard £18.36 - £22.95

Napoleon's French Middle Imperial Guard

This set is now on pre-order and orders should start shipping from 12th November. For those ordering this set between now and the 12th will receive a free transfer sheet.

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Austrian Napoleonic Landwehr 1808-1815 £18.36 - £22.95

Austrian Napoleonic Landwehr 1808-1815

This set contains 56 Austrian Landwehr figures. 2 x officers 2 x standard bearers 2 x Drummers 2 x mounted colonels 48 x infantry The officers and Mounted colonels have.

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Austrian Napoleonic Infantry 1806-1815 £18.36 - £22.95

Austrian Napoleonic Infantry 1806-1815

This set contains 56 Austrian Infantry figures. 2 x officers 2 x standard bearers 2 x Drummers 2 x mounted colonels 48 x infantry The officers and Mounted colonels have.

* Discounts available for bulk purchases

Austrian Napoleonic Grenadiers 1798-1815 £18.36 - £22.95

Austrian Napoleonic Grenadiers 1798-1815

This set contains 56 Austrian Grenadier figures. 2 x officers 2 x standard bearers 2 x Drummers 2 x mounted colonels 48 x infantry The officers and Mounted colonels have.

* Discounts available for bulk purchases

Napoleon's French Old Guard Chasseurs £18.36 - £22.95

Napoleon's French Old Guard Chasseurs

The Chasseurs are our second set of Napoleon's Old Guard and completes the infantry for Napoleon's old 'Grumblers'! You can now truly represent the Guard massed columns advancing to break.

* Discounts available for bulk purchases

British Napleonic Foot Artillery £18.36 - £22.95

British Napleonic Foot Artillery

This set contains: 3 Guns with barrel options of - short 6 pdr - long 6 pdr -9 pdr -5.5 inch howitzer 3 limbers 15 crew featuring - Multiple arm options - Head variants.

* Discounts available for bulk purchases

French Napoleonic Infantry 1804 - 1807 £18.36 - £22.95

French Napoleonic Infantry 1804 - 1807

This 60 figure set features heads in bicornes and new grenadier heads. We have also included porte fanion arms.

* Discounts available for bulk purchases

British Napoleonic Highlander Flank Companies £18.36 - £22.95

British Napoleonic Highlander Flank Companies

These sets contain the following components: 4 Officers in trousers 4 Standard Bearers 4 Pipers 4 drummers 4 NCO's 24 infantry in march attack/advancing poses 12 infantry in standing firing/loading.

* Discounts available for bulk purchases

British Napoleonic Highlander Centre Companies £18.36 - £22.95

British Napoleonic Highlander Centre Companies

These sets contain the following components: 4 Officers in trousers 4 Standard Bearers 4 Pipers 4 drummers 4 NCO's 24 infantry in march attack/advancing poses 12 infantry in standing firing/loading.

* Discounts available for bulk purchases

French Napoleonic Infantry 1807 - 1812 £18.36 - £22.95

French Napoleonic Infantry 1807 - 1812

This 60 figure set features heads in shakos and new grenadier heads. We have also included porte fanion arms.

* Discounts available for bulk purchases

British Peninsular Infantry Flank Companies £18.36 - £22.95

British Peninsular Infantry Flank Companies

28mm hard plastic Napoleonic figures 52 figure infantry set with Stovepipe shako? s and shoulder wings. The set includes command figures for officers, standard bearers, NCO? s, drummers, 4 flags and fast.

* Discounts available for bulk purchases

Waterloo British Infantry Flank Companies £18.36 - £22.95

Waterloo British Infantry Flank Companies

28mm hard plastic Napoleonic figures 52 figure infantry set with Belgic shako? s and shoulder wings. The set includes command figures for officers, standard bearers, NCO? s, drummers, 4 flags and fast.

* Discounts available for bulk purchases

British Peninsular Infantry Centre Companies £18.36 - £22.95

British Peninsular Infantry Centre Companies

28mm hard plastic Napoleonic figures 52 figure infantry set with Stovepipe shakos. This set includes command figures for officers in bicornes, standard bearers, NCO? s, drummers, 4 flags and fast play.

* Discounts available for bulk purchases

Waterloo British Infantry Centre Companies £18.36 - £22.95

Waterloo British Infantry Centre Companies

28mm hard plastic Napoleonic figures 52 figure infantry set with Belgic shako? s. The set includes command figures for officers, standard bearers, NCO? s, drummers, 4 flags and fast play rules.

* Discounts available for bulk purchases

French set of Regimental Colours £12.50

French set of Regimental Colours

This superb set of standards has also been designed by Victrix? s own Stephen Hales and includes 24 Regimental standards for individual French infantry units. At a cost of only ?15.

28mm Resin British Peninsular War ensigns and officers £11.95

28mm Resin British Peninsular War ensigns and officers

We have a new pack of 28mm resin British Peninsular War ensigns and officers. We created this pack to give you a really characterful look to your British battalions. Figures.

Austrian A4 flag sheet 1792,1804 and 1806 issues £10.00

Austrian A4 flag sheet 1792,1804 and 1806 issues

18 Austrian flags od the 1792, 1804 and 1806 issues. the 1792 and 1804 issue were used into 1809 and beyond. Regiments tended to hold onto their flags until they.

French 1812 issue A4 flag sheet for Line and Legere £10.00

French 1812 issue A4 flag sheet for Line and Legere

Hascovir, Hascovir

Aciclovir

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Tagged with hascovir

Co ludzie mysla o HASCOVIR PRO? Trudno wlasciwie stwierdzic. Jednakze nalezy sie z tymi opiniami zapoznac i potem nabyc produkt, w tym przypadku HASCOVIR PRO Ale jednak opinie te czesto moga byc zdecydowanie odmienne. To rowniez nie jest niespodzianka. Bo czesto niektorzy wychwalaja HASCOVIR PRO a inni ludzie wrecz przeciwnie. Ufamy, ze komentarze pod tym artykulem pozwola wam ustalic prywatne zdanie. Zapraszam do komentowania. Zdrowie to moment zupelnego, dobrego poczucia cielesnego, psychicznego i spolecznego, a nie zaledwie jako brak dolegliwosci lub niedoleznosci. W ostatnim czasie formula ta zostala dopelniona o sprawnosc wiedzenia ciekawego zycia spolecznego i materialnego” a takze format spirytualny Dzialanie PANTHENOL emulsja 6 % (pianka w aerozolu). przynosi ulge, uspokaja i przyjemnie ochladza skore po nadmiernym opalaniu albo podrazniona w inny sposob. latwo wchlanialna pianka umozliwia aplikacje tez na wrazliwe miejsca, gdzie wcieranie moze powodowac bol. D-panthenol przyspiesza proces gojenia sie drobnych powierzchniowych zranien, wlacznie z lekkimi oparzeniami slonecznymi i odnawia uszkodzona tkanke. utrzymuje zdrowy stan stan owlosionej skory glowy, poprawia jakosc i wzrost wlosow, ogranicza ich wypadanie, lamanie i rozdwajanie sie. Wazna role dla zdrowia zwyklego czlowieka odgrywa zwykle profilaktyka. Wino powinny polubic kobiety zblizajace sie do menopauzy, bowiem picie trzech lampek wina gronowego tygodniowo podnosi nieco poziom estrogenow, czyli zenskich hormonow plciowych, ktorych jajniki wraz z wiekiem produkuja coraz mniej. A wyzszy poziom estrogenow to rowniez lagodniejsza menopauza. Sprzyja nie mniej jednak chorobie wrzodowej zoladka i dwunastnicy. Biale wino moze takze o 60 proc. zwiekszyc wydzielanie sokow zoladkowych (jednym ze skladnikow moze byc kwas solny), ktore w nadmiarze powinny uszkadzac sluzowke wyscielajaca nasz zoladek i dwunastnice. Prowadzi to rowniez do jej nadzerek i owrzodzen. Pamietaj, ze stan ciala zalezy wylacznie od twojego postepowania. Na koniec pare zdan przestrogi. Z przeprowadzonych badan wynika, ze co czwarty Polak cierpi na infekcje grzybicza, a co piaty ma grzybice plytki paznokciowej. Najczesciej u mieszkancow naszego kraju wystepuje nie mniej jednak grzybica stop. Lekarze bija na alarm, by zachowywac higiene, nie wahac sie przyjsc do specjalisty po porade i stosowac profilaktyke zapobiegajaca chorobom grzybiczym, a w miare mozliwosci regularnie oczyszczac organizm. Wloscy naukowcy opracowali szczepionke, ktora ma chronic przed atakami chorobotworczych grzybow. Moze byc ona nie mniej jednak wciaz jeszcze w fazie badan klinicznych i nie mozna jej na razie powszechnie stosowac.

Ludzie szukaja opinii o HASCOVIR PRO. I to nie budzi watpliwosci, bo gdy trzeba nabyc produkt, to warto poznac opinie innych konsumentow. Ale jednak opinie te bywaja zdecydowanie odmienne. Jedni wychwalaja HASCOVIR PRO a inni wrecz przeciwnie. Moze komentarze pod tym tekstem pomoga wam uzyskac wlasne zdanie. Bardzo czesto to zdanie innych ludzi decyduje o tym czy kupujemy czy tez nie. Zapraszam do komentowania. Zdrowie to moment zupelnego, nalezytego poczucia fizycznego, duchowego i spolecznego, a nie wylacznie jako brak choroby albo zniedoleznienia. W ostatnim czasie formula ta zostala uzupelniona o sprawnosc kontynuowania produktywnego zycia spolecznego i ekonomicznego” a takze format spirytualny Dzialanie PANTHENOL emulsja 6 % (pianka w aerozolu). przynosi ulge, uspokaja oraz przyjemnie ochladza skore po nadmiernym opalaniu albo podrazniona w inny sposob. latwo wchlanialna pianka umozliwia aplikacje tez na wrazliwe miejsca, gdzie wcieranie moze powodowac bol. D-panthenol przyspiesza proces gojenia sie drobnych powierzchniowych zranien, wlacznie z lekkimi oparzeniami slonecznymi oraz odnawia uszkodzona tkanke. utrzymuje zdrowy stan stan owlosionej skory glowy, poprawia jakosc oraz wzrost wlosow, ogranicza ich wypadanie, lamanie oraz rozdwajanie sie. Wazna funkcje dla zdrowia zwyklego czlowieka odgrywa zwykle profilaktyka. Wino powinny polubic kobiety zblizajace sie do menopauzy, bowiem picie trzech lampek wina gronowego tygodniowo podnosi nieco poziom estrogenow, czyli zenskich hormonow plciowych, ktorych jajniki wraz z wiekiem produkuja coraz mniej. A wyzszy poziom estrogenow to takze lagodniejsza menopauza. Sprzyja jednakze chorobie wrzodowej zoladka oraz dwunastnicy. Biale wino moze takze o 60 proc. zwiekszyc wydzielanie sokow zoladkowych (jednym ze skladnikow moze byc kwas solny), ktore w nadmiarze powinny uszkadzac sluzowke wyscielajaca ludzki zoladek oraz dwunastnice. Prowadzi to takze do jej nadzerek oraz owrzodzen. Zapamietaj, ze stan twojego zdrowia zalezy jedynie od twojego postepowania. Na koniec pare slow przestrogi. Z przeprowadzonych badan wynika, ze co czwarty Polak cierpi na infekcje grzybicza, a co piaty posiada grzybice plytki paznokciowej. Najczesciej u mieszkancow naszego kraju wystepuje nie mniej jednak grzybica stop. Lekarze bija na alarm, by zachowywac higiene, nie wahac sie przyjsc do specjalisty po porade oraz stosowac profilaktyke zapobiegajaca chorobom grzybiczym, a w miare mozliwosci regularnie oczyszczac organizm. Wloscy naukowcy opracowali szczepionke, ktora posiada chronic przed atakami chorobotworczych grzybow. Moze byc ona nie mniej jednak wciaz jeszcze w fazie badan klinicznych oraz nie mozna jej na razie powszechnie stosowac.

czytajmy!

Se%20parece - Spanish To English Translation, Paracen

Translate Se%20parece To English

look alike, look

(v.) = bear + similarity ; look + alike ; take after . Ex: If one walks round a large general booskshop and carefully appraises the stock on display it becomes clear quite quickly that there are many types of books which seem to bear a strong similarity to each other . Ex: No two paper moulds of the hand-press period were ever precisely identical, and individual moulds can be identified by their paper images; even the two moulds of a pair, which were deliberately made to look alike . can be told apart by the paper made in them . Ex: Libraries are like chameleons: they take after the complexion of society .

Etrosteron, Etrosteron

CIPROFLOXACIN is a quinolone antibiotic. It can kill bacteria or stop their growth. It is used to treat many kinds of infections, like urinary, respiratory, skin, gastrointestinal, and bone infections. It will not work for colds, flu, or other viral infections.

What should my health care professional know before I take this medicine?

They need to know if you have any of these conditions: child with joint problems heart condition kidney disease liver disease seizures disorder an unusual or allergic reaction to ciprofloxacin, other antibiotics or medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding

How should I take this medicine?

Take this medicine by mouth with a glass of water. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think your are better. Do not skip doses or stop your medicine early.

You can take this medicine with food or on an empty stomach. It can be taken with a meal that contains dairy or calcium, but do not take it alone with a dairy product, like milk or yogurt or calcium-fortified juice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following: cisapride droperidol terfenadine tizanidine

This medicine may also interact with the following: antacids caffeine cyclosporin didanosine (ddI) buffered tablets or powder medicines for diabetes medicines for inflammation like ibuprofen, naproxen methotrexate multivitamins omeprazole phenytoin probenecid sucralfate theophylline warfarin

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while taking this medicine?

Tell your doctor or health care professional if your symptoms do not improve.

Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Avoid antacids, aluminum, calcium, iron, magnesium, and zinc products for 6 hours before and 2 hours after taking a dose of this medicine.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue breathing problems confusion, nightmares or hallucinations feeling faint or lightheaded, falls irregular heartbeat joint, muscle or tendon pain or swelling pain or trouble passing urine redness, blistering, peeling or loosening of the skin, including inside the mouth seizure unusual pain, numbness, tingling, or weakness

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): diarrhea nausea or stomach upset white patches or sores in the mouth

This list may not describe all possible side effects.

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

Allobeta Rezeptfrei Kaufen ? Qualitat; ? Mit Niedrigen Preisen; ? Lieferung, Allobeta

Allopurinol wird zur Behandlung von Gicht eingesetzt. Es wird verwendet, um hohen Harnsaurespiegel im Blut oder Urin von bestimmten Arten von Krebs-Chemotherapie zu behandeln. Es wird auch verwendet, um bestimmte Patienten mit Calciumoxalat Nierensteinen und hohen Mengen an Harnsaure im Urin zu behandeln. Allopurinol ist ein Xanthinoxidase-Inhibitor. Es funktioniert durch eine Senkung der korpereigenen Produktion von Harnsaure.

Verwenden Sie Allopurinol, wie von Ihrem Arzt verordnet wurde.

Nehmen Sie Allopurinol durch den Mund nach den Mahlzeiten Magenverstimmung zu verringern.

Trinken extra Flussigkeiten wahrend der Einnahme Allopurinol wird empfohlen. Fragen Sie Ihren Arzt fur Anweisungen.

Weiter zu Allopurinol, auch wenn Sie sich wohl fuhlen. Verpassen Sie keine Dosis.

Wenn Sie eine Dosis von Allopurinol, bringen Sie es so bald wie moglich. Wenn es fast Zeit fur Ihre nachste Dosis ist, uberspringen Sie die vergessene Dosis und gehen Sie zuruck zu Ihrem regelma?igen Dosierungsschema. Nehmen Sie nicht 2 Dosen auf einmal.

Fragen Sie Ihren Arzt Fragen konnen Sie sich uber die Verwendung von Allopurinol haben kann.

Shop Allopurinol bei Raumtemperatur zwischen 68 und 77 Grad F (20 und 25 Grad C). Lager weg von der Hitze, Feuchtigkeit und Licht. Nicht im Bad. Halten Sie Allopurinol au?erhalb der Reichweite von Kindern und weg von Haustieren.

Verwenden Sie KEINE Allopurinol, wenn:

Sie sind allergisch gegen jegliche Zutaten in Allopurinol.

Fragen Sie Ihren Arzt oder Ihre Arztin sofort, wenn einer dieser Punkte auf Sie zutreffen.

Einige medizinische Bedingungen konnen mit Allopurinol interagieren. Informieren Sie Ihren Arzt oder Apotheker, wenn Sie irgendwelche medizinischen Bedingungen haben, vor allem, wenn einer der folgenden Punkte auf Sie zutrifft:

wenn Sie schwanger sind, planen, schwanger zu werden, oder stillen

wenn Sie verschreibungspflichtige oder nicht verschreibungspflichtige Arzneimittel, pflanzliche Zubereitung oder Nahrungserganzungsmittel

wenn Sie Allergien gegen Medikamente, Nahrungsmittel oder andere Substanzen,

wenn Sie eine Nieren-oder Lebererkrankungen, Herz-Probleme (zB Herzinsuffizienz), Knochenmark-Probleme, Bluthochdruck oder Diabetes.

Einige Arzneimittel konnen mit Allopurinol interagieren. Informieren Sie Ihren Arzt, wenn Sie andere Arzneimittel einnehmen, vor allem einer der folgenden Eigenschaften sind:

Amoxicillin oder Ampicillin, weil das Risiko der Entwicklung eines Hautausschlag kann erhoht werden

Chlorpropamid, weil das Risiko von niedrigem Blutzucker erhoht werden kann

Dicumarol oder oralen Antikoagulanzien (zB Warfarin), weil das Risiko von Blutungen kann durch Allopurinol erhoht werden

Thiaziddiuretika (beispielsweise Hydrochlorothiazid) oder Urikosurika (beispielsweise Probenecid), weil sie das Risiko von Allopurinol der Nebenwirkungen

Cyclosporin oder Thiopurine (zB Azathioprin, Mercaptopurin), weil das Risiko der Nebenwirkungen von Allopurinol erhoht werden kann.

Dies kann nicht eine vollstandige Liste aller Interaktionen, die auftreten konnen. Fragen Sie Ihren Arzt, wenn Allopurinol mit anderen Medikamenten, die Sie einnehmen. Prufen Sie mit Ihrem Arzt, bevor Sie starten, stoppen, oder andern Sie die Dosis einer Medizin.

Wichtige Sicherheitshinweise:

Allopurinol konnen Schlafrigkeit. Dieser Effekt kann noch schlimmer, wenn Sie es mit Alkohol oder bestimmte Medikamente. Verwenden Sie Allopurinol mit Vorsicht. Nicht Auto fahren oder andere moglicherweise unsichere Aufgaben, bis Sie, wie Sie darauf reagieren.

Sie konnen zu einem Anstieg der Gicht-Attacken fur mehrere Monate nach der Einnahme von Allopurinol beginnen. Ihr Arzt kann Ihnen ein anderes Arzneimittel (Colchicin) zu helfen, verringern diese Gichtanfalle. Fragen Sie Ihren Arzt, wenn Sie haufig oder schwerer Gicht-Attacken erleben.

Es kann 2 bis 6 Wochen in den vollen Genuss von Allopurinol erhalten.

Nehmen Sie nicht mehr als die empfohlene Dosis oder Verwendung langer als ohne Rucksprache mit Ihrem Arzt verordnet.

Allopurinol ist nicht fur die Linderung einer akuten Gichtanfall nutzlich.

Befolgen Sie die Diat-und Sportprogramm, die Sie von Ihrem Arzt oder Arztin.

Lab-Tests, einschlie?lich Harnsaurespiegel und Nieren-und Leberfunktion, kann durchgefuhrt werden, wahrend Sie Allopurinol verwenden. Diese Tests konnen verwendet werden, um Ihren Zustand zu uberprufen oder auf Nebenwirkungen zu uberwachen. Achten Sie darauf, alle Arzt-und Labor-Terminen.

Schwangerschaft und Stillzeit: Wenn Sie schwanger werden, mit Ihrem Arzt. Sie mussen die Vorteile und Risiken der Verwendung von Allopurinol zu diskutieren, wahrend Sie schwanger sind. Allopurinol ist in der Muttermilch gefunden. Wenn Sie sind oder werden stillen, wahrend Sie Allopurinol, Sie bei Ihrem Arzt uberprufen. Diskutieren Sie mogliche Risiken fur Ihr Baby.

Alle Arzneimittel konnen Nebenwirkungen haben, die aber viele Menschen haben keine oder nur geringfugige, Nebenwirkungen.

Erkundigen Sie sich bei Ihrem Arzt, wenn dieser am haufigsten auftretenden Nebenwirkungen fortbestehen oder storend empfunden werden:

Arztlich behandeln lassen, sofort, wenn dieser schwere Nebenwirkungen auftreten:

Schwere allergische Reaktionen (Hautausschlag, Nesselsucht, Juckreiz, Atembeschwerden, Engegefuhl in der Brust, Schwellungen im Mund-, Gesichts-, Lippen oder Zunge), Blut im Urin oder Schmerzen beim Wasserlassen, dunkler Urin, Fieber, Schuttelfrost, oder Halsschmerzen, Reizungen der Augen, Gelenkschmerzen, Appetitlosigkeit, rot, geschwollen, Blasen, oder Schalen der Haut, Magenschmerzen, unerklarlicher Gewichtsverlust, ungewohnliche blaue Flecken oder Blutungen, ungewohnliche Muskelschmerzen oder Schwache, Gelbfarbung der Haut oder Augen.

Dies ist keine vollstandige Liste aller Nebenwirkungen, die auftreten konnen. Wenn Sie Fragen zu Nebenwirkungen haben, wenden Sie sich an Ihren Arzt.

Kunden, die diesen Artikel gekauft haben, schaffen auch folgende Artikel an.

Urheberrecht © 2004-2016 Alle Rechte vorbehalten

Valsan Of Miami In Miami, Fl 33142, Valsan

Valsan Of Miami

over a year ago

jejejeje this is a Cuban store, the usually sell to Cubans in Miami to send to Cuban in Cuba. Most of the employees don't speak English and they bring that horrible attitude from Cuba. I guess if they are cheap you have to deal with the attitude. Carmen is the owners daughter. jejejeje good luck shopping at that store.

Susie R.

over a year ago

VALSAN IN KENDALL – I have been to Valsan in Kendall Drive on two occassions. And everytime I go there, I feel like the employees are watching and following me all around. I know that their jobs are to make sure that nothing is stolen, but it is a bit annoying to know that someone is following you, when you just want to see what they have.

At first I thought it was just myself, but on my second visit, I took my 14 year old daughter, and after a while she asked me. Mom, are these people following us around, I turned to her and said. Yes they are. They want to make sure that you do not steal anything. She said to me. i want to leave. So we left empty handed.

You have cameras. So stop following people around like we are criminals. It does not feel good to be shop and have someone right next to you all the time. It is annoying and I do not think that I, or my daughter will be returning there anytime soon. I also asked a few friends of mine who also have shopped there, and they agree with me.

Juan Gutierrez

over a year ago

BAD CUSTOMER SERVICE – I WENT TO VALSAN WITH MY MOTHER TO BUY HER SOME PANTS AND BLOUSES. THE ONLY THING I

GOT BESIDES GOOD PRICES WAS A BAD ATTITUDE

AND TERRIBLE SERVICE FROM A LADY NAMED CARMEN AT THE CHECK OUT FOR THE THIRD VISIT

TO THE STORE. THE FIRST TWO TIMES I LET IT GO BECAUSE I THOUGHT MAYBE SHE WAS HAVING A BAD DAY BUT NOW I REALIZE ON MY THIRD VISIT IS,

WHAT YOU SEE IS WHAT YOU GET. THIS WAS THE NEW STORE IN KENDALL. I'M NOT GOING BACK THERE AND I WOULD'NT RECOMMEND IT TO ANYONE.

Comprar Halthrow (Flomax) Sin Receta, Halthrow

compra Halthrow (Flomax) en linea sin receta

Halthrow (Flomax) Explicacion

Halthrow es realmente un tratamiento ideal dentro de la batalla hacia asociada con HPB. El enfoque en seria para hacer frente a la hiperplasia prostatica inofensivos o prostatica aun mas grande.

Este tratamiento en particular es realmente llevando a cabo a traves de calmar los buques de sangre, asi como el tejido muscular asociados con la vejiga, asi como la creacion de prostata orinando mas simple. Realmente es bloqueador adrenergico.

Halthrow tambien puede ser referido como tamsulosina, Veltam, Halthrowtra, Urimax.

titulo general asociada con Halthrow es en realidad tamsulosina.

Marca asociada con Halthrow Halthrow es en realidad.

Halthrow (Flomax) Dosis

Halthrow viene en:

cero. Material de friccion 2mg Baja Dosis

cero. Material de friccion dosis regular 4mg

Halthrow viene en tabletas, asi como el formulario de contacto fluido.

Obtener tabletas Halthrow por la boca.

Por lo general, no moler o incluso masticar esto.

Obtener Halthrow diario de media hora despues de la cena, al mismo tiempo cada dia, junto con el agua potable.

Si usted desea lograr mejores resultados por lo general no dejar de usar Halthrow de repente.

Halthrow (Flomax) Careciendo asocia con dosis

Por lo general, no reciben doble dosis. En caso de que salte la dosis que necesita para llevar una vez se tiene en cuenta en lo que respecta a su deficiente. Cuando es hora de la dosis que necesita para llevar a cabo su propia rutina de dosificacion normal.

Halthrow (Flomax)

En el caso de una sobredosis Halthrow y que tambien se evita gran usted necesita comprobar hacia fuera su medico o incluso el medico de inmediato. Asociado con Halthrow sobredosis: desmayos, latido del corazon rapido, poros frio y la piel, migrana, mareo, fatiga, vision borrosa, fria y humeda.

Halthrow (Flomax) Espacio de almacenamiento

Tienda en temperaturas de espacio entre 10 y 30 niveles de D (59, asi como ochenta y seis niveles F) de humedad, asi como la temperatura. Fortalecer cualquier tipo de medicamento sin tocar a partir del dia de vencimiento. Mantener colocado de forma segura fuera del camino de los ninos.

Halthrow (Flomax) Efectos negativos

Halthrow ofrece los efectos negativos. El mas tipico tienden a ser:

material de friccion mareo

sensacion material de friccion con sueno

un poco de material de friccion debilidad

insomnio. material de friccion

Material encuentro molestias friccion

material de friccion climax poco comun

friccion material de dolor de espalda baja

problemas con material de friccion de estar intima

nasal o material de friccion zona nasal incluso tapada

amigdalas doloridos material de friccion

material de friccion diarrea

asociado con material de friccion contaminacion

problemas con material de friccion de la vista

efectos negativos Mucho menos tipicos y graves en todo usando Halthrow:

respuestas reaccion alergica (urticaria, inhalando y exhalando cuestiones, alergia, asi como la erupcion) material de friccion

grave material de friccion mareo

material de friccion prurito

problemas con material de friccion ereccion del pene

Los efectos negativos son indicaciones se basan en medicamentos que podrian estar utilizando pero, ademas, se basan en su condicion de bienestar y otros aspectos.

Halthrow (Flomax) Contraindicaciones

Por lo general no reciben Halthrow en caso de que son sensibles con el fin de elementos Halthrow.

Por lo general no reciben Halthrow si usted esta esperando otra manera tiene la intencion de tener un hijo, si no que realmente eres una mama medica. Danos Halthrow su hijo.

Tenga cuidado junto con Halthrow en caso de que se ven afectados y tienen una breve historia asociada con la malignidad de prostata, enfermedades del higado, la enfermedad renal.

Si usted quiere tener un tratamiento quirurgico que necesita ser cauteloso junto con Halthrow.

Juega el papel de la utilizacion prudente Halthrow para alfusozin (tales porque Uroxatral), doxazosina (como ya Cardura), prazosina (tales porque Minipress), terazosina (tales porque Hytrin), warfarina (Coumadin porque tal); antibioticos, por ejemplo, eritromicina (tales porque Electronico. Electronica. H. E-Mycin, Erythrocin, Ery-Tab), azitromicina (Zithromax porque tal), claritromicina (tales porque Biaxin), itraconazol (tales porque Sporanox), ciprofloxacina ( tales porque Cipro), ketoconazol (tales porque Nizoral); medicamentos para la presion arterial cardiovasculares o incluso bajos, por ejemplo, verapamilo (tales porque Isoptin, Calan, Verelan, Covera), diltiazem (tales porque Tiazac, Cardizem, Dilacor); cimetidina (por ejemplo, porque Tagamet); Los medicamentos contra el VIH / SIDA, por ejemplo, ritonavir (Norvir porque tal), indinavir (tales porque Crixivan), saquinavir (tales porque Fortovase, Invirase), nelfinavir (Viracept porque tal); ciclosporina (por ejemplo porque Sandimmune, Gengraf, Neoral); antidepresivos, por ejemplo, fluvoxamina (tales porque Luvox), citalopram (tales porque Celexa), paroxetina (Paxil porque tales), escitalopram (por ejemplo porque Lexapro), sertralina (Zoloft porque tales), fluoxetina (por ejemplo porque Sarafem, Prozac); metronidazol (Flagyl tales porque, Protostat).

Evite las bebidas alcoholicas.

Mantener Halthrow de ninos y no hacer esto algunas otras personas con respecto a la utilizacion.

Por lo general, no dejar de usar Halthrow de repente.

Halthrow (Flomax) Preguntas comunes

Queen: ?Que es exactamente Halthrow?

El: Halthrow es realmente un tratamiento ideal dentro de la batalla hacia asociada con HPB. El enfoque en seria para hacer frente a la hiperplasia prostatica inofensivos o prostatica aun mas grande. Este tratamiento en particular es realmente llevando a cabo a traves de calmar los buques de sangre, asi como el tejido muscular asociados con la vejiga, asi como la creacion de prostata orinando mas simple. Realmente es adrenergico blocker. A

Queen: ?Cuales son exactamente los efectos negativos de Halthrow?

El: Halthrow ofrece los tipicos efectos negativos, por ejemplo: mareos, sensacion de sueno, un poco de debilidad, insomnio, malestar asociado con el encuentro, el climax poco comun, dolor lumbar, problemas con la vida intima, nasal o incluso nasal congestionada area, dolorido amigdalas, diarrea, asociados con la contaminacion, problemas con la vista. Sin embargo en la situacion que se asocia con ser rechazado asociado con componentes Halthrow que son capaces de encontrar efectos negativos mas graves: asociado con la respuesta de reaccion alergica (urticaria, problemas con la inhalacion y la exhalacion, la alergia, la inflamacion, cierre), mareos graves, prurito, problemas con el pene ereccion. La probabilidad de efectos negativos a aparecer depende de la posicion de bienestar, asi como, naturalmente, en la receta Halthrow posterior correcta medications. A

Queen: ?Cuales son exactamente general, asi como las marcas asociadas con Halthrow?

El: titulo general asociada con Halthrow es en realidad tamsulosina. Marca asociada con Halthrow es en realidad Halthrow. A

Reina: ?Se puede realmente consumir alcohol?

El: Por supuesto que no, lo que realmente es inaceptable aprecian alcoholica beverages. A

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Anginovag Spray, Anginovag

ANGINOVAG SPRAY

Glimmer of Hope is pleased to announce the launching of Candy for the Cure. Candy for the Cure is a program developed by Glimmer of Hope to help raise funds for the nations largest under 40 breast cancer study in the country. Every dollar raised goes to support breast cancer research and the fight for a cure.

Purchase your candy bar online HERE or from any of our participating retailers listed below, then look for the unique entry code on the inside of the wrapper, and fill out the entry form that includes your unique entry code. You will be entered to win and the drawing will take place on July 1, 2009.

*Wrapper must be presented when claiming prize.

T-Bones Inc 100 Vip Drive Wexford, PA 15090

Salon Vivace Spa Treesdale Pine Township Location 620 Warrendale Road Gibsonia, PA 15044

Hair it Is and Nails Too 977 Perry Hwy Ste 4 Pittsburgh, PA 15237

Congratulations to our Winners

Grand Prize Tiah Popa

Second Prize Linda David

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Cipcal - Order Now! Canadian Pharmacy U E W D R Y W F, Adiecal

Cipcal 500mg/250IU + FREE BONUS PILLS

Bonus Policy

Free Regular Airmail (10-21 days) for orders starting with $150.00 .

Free Express Courier (US Customers Only) (8-14 days) for orders starting with $300.00 .

Free insurance (guaranteed reshipment if delivery failed) for orders starting with $200.00 .

Description

Cipcal is a vitamin and mineral supplement containing calcium carbonate and vitamin D3.

Each tablet contains 1250 mg of calcium carbonate equivalent to calcium 500 mg and vitamin D3 250 U. I.

Full product description

Recommendations

Follow the direction for using this medicine provided by your doctor.

Ingredients

Calcium Carbonate, Vitamin D3

Testimonials

I am 34 years old and unfortunately I suffer from calcium deficiency. As a result my bones are more fragile than those of other people and I am therefore limited in activities and have to think over every step in my life. I try to avoid falls, never ice skate or ski, I am carefull with stairs and so on. This life is quite as that of a disabled person, cause I seem not to have any deadly illness but I have to avoid numerous activities in order to stay ok. Recently my doctor has put me on Cipcal - a medical supplement containing enough calcium for my body. Before Cipcal I also have tried many other meds and natural remedies, used to eat tons of milk products and vitamins. It as all very difficult and bothering. With Cipcal everything is so much easier. The medication is really effective and I enjoy life greatly now.

Joe Melville, Ottawa

I buy this medication for my younger son. He is extremely fond of ice hockey and plays his favorite game every day. But it is very dangerous and traumatic sport. I want to support him in his interest to big sport, but I also want my 7-year old boy to stay healthy and successful. So I have consulted our doctor about how I can help him and protect him as well and he advised me to buy vitamins containing calcium to make the bones of my son stronger and thinker. I buy Cipcal for Joe every month and he takes it together with other kid's vitamins on a regular basis. He is a very healthy boy and almost never falls ill. Besides he is active and is one of the best ice hockey players in his school. I am very proud of him and I am also very grateful to Cipcal for the protection it provides for my boy. In addition to this I am pregnant now expecting another son and I also take Cipcal following my doctor's advice to provide calcium for the little one growing inside me. This medication is wonderful and I advice it to others.

Isabella M. Carson City

I buy Cipcal regularly for my parents. They are elderly people and they live in a neighbor state, so I can not visit them too often. But I want to make sure I do my best to protect them and make their lives easier. They are too old to keep as active as they used to be, their health is no longer that strong, and they can not take part in the activities that caused no problems before. After 60 your bones get more and more fragile, they lose calcium and such diseases as osteoporosis and other similar disorders affect their joints and ligaments. In winter when it is slippery outside I constantly worry about how they walk to the local store to buy ordinary daily products. But with Cipcal I can rest assured, my parents get enough calcium and their bones are protected. I know it because my parents feel better with the medication, their joints are not that painful as before and they can walk longer distances. In other words this supplement is excellent for elderly people with fragile bones. I would recommend to all the people who need additional dosage of calcium.

Kim Bradley, Rapid City

Bine Ati Venit La Farmacia Farmalex, Farmalex

Motto:

“Toate visele par imposibile pana cand le indeplineste cineva” – Barry Neil Kaufman

Fideli principiului potrivit caruia, intr-o familie, relatiile se construiesc pe termen nelimitat, profesionistii echipei Farm Alex s-au gandit sa consolideze legaturile create intre ei si pacientii in slujba carora si-au angajat toata pregatirea si onestitatea. Asa s-a nascut ideea infiintarii unei pagini web.

Misiune

Sanatatea este cel mai de pret lucru pe care il are fiecare individ. Noi intelegem acest lucru si suntem permanent alaturi de pacientii nostri, venind in intampinarea acestora cu solutii la problemele lor reale:

Informatii utile

Ori de cate ori aveti nevoie de informatii despre produse, cand cautati un medicament si nu-l gasiti, aveti suspiciuni legate de eventuale reactii adverse produse de tratamentul dumneavoastra, daca va intereseaza promotiile si campaniile noastre, dar si noutati din domeniul sanatatii nu ezitati sa trimiteti un email la:

Veti primi raspunsul nostru tot prin email, confidential.

Medicul dermatolog va raspunde la intrebari legate de ingrijirea tenului:

Produsele IVATHERM . cu apa termala Herculane sunt de acum si in farmacia noastra. Afla mai multe despre puterea binefacatoare a apei termale si despre cum iti poti ingriji tenul la orice varsta:

Contact:

FarmAlex Buzau

Str. Al. Marghiloman, nr 94, cod postal 120107 Tel: 0238/721027 Email: buzau@farmaciibuzau. ro

Program

Luni-Vineri: 08:00-21.00 Sambata: 08.00-18.00 Duminica: 08.00-14.00

FarmAlex Padina 1

str. Principala, comuna Padina, cladirea dispensarului tel: 0238/534900 Email: padina@farmaciibuzau. ro

Program

FarmAlex Padina 2

Programul farmaciilor de garda

Zambeste! E gratis

More Information About Ketotifen, Cipanfeno

More information about Ketotifen

3 years and Adults: Ophthalmic: Instill 1 drop into the affected eye(s) twice daily, every 8-12 hours

Patient Education

For use in eyes only. Do not let tip of applicator touch eye; do not contaminate tip of applicator (may cause eye infection, eye damage, or vision loss). Not to be used to treat contact lens-related irritation. Wait at least 10 minutes before putting soft contact lenses in. Do not wear contact lenses if eyes are red. Store at room temperature. Pregnancy/breast-feeding precautions: Inform prescriber if you are pregnant or breast-feeding.

Dental Health: Effects on Dental Treatment

Key adverse event(s) related to dental treatment: Pharyngitis.

Dental Health: Vasoconstrictor/Local Anesthetic Precautions

No information available to require special precautions

Mental Health: Effects on Mental Status

Mental Health: Effects on Psychiatric Treatment

May cause dry eyes which can be exacerbated by anticholinergic agents or psychotropics with significant anticholinergic activity

Dosage Forms

Solution, ophthalmic, as fumarate: 0.025% (5 mL) [contains benzalkonium chloride]

International Brand Names

Alertax ® (DO); Alleal ® (IT); Allerket ® (IT); Apo-Ketotifen ® (CA); Asdron ® (BR); Asmafen ® (NZ); Asmalergin ® (BR); Asmanoc ® (TH); Asmax ® (BR); Asmen ® (BR); Astafen ® (TR); Asthafen ® (RU); Asumalife YSP ® (SG); Beatifen ® (SG); Bentifen ® (IT); Cetotifeno ® (BR); Chetofen ® (IT); Chetotifene Merck ® (IT); Cipanfeno ® (PT); Denerel ® (RU, SG); Dhatifen ® (SG); Difen ® (CO); Dihalar ® (HR, SI); Erliten ® (SG); Frenasma ® (RO); Fumarato de Cetotifeno ® (BR); Fumast ® (TR); H-Ketotifen ® (RO); Ibis ® (TH); Intifen ® (ID); Kasmal ® (MX); Katifen ® (TH); Kelme ® (AR); Kenaler ® (CO); Kenefen ® (TH); Ketarfen ® (RO); Ketasma ® (ES, IN); Keten ® (TH); Ketifen ® (BD, DO, TH); Ketocev ® (AR); Ketof ® (DE, LU, PL, RO, RU); Ketofen ® (TH); Ketofex ® (DE); Ketoftil ® (IT); Keto-Gal ® (RO); Ketohexal syrup ® (ZA); Keto ® (TH); Ketotifen beta ® (DE); Ketotifen ® (BG, CZ, PL, RO, YU); Ketotifen Heumann ® (DE); Ketotifen LFM ® (HU); Ketotifen Nordia ® (SG); Ketotifen Nycomed ® (AT); Ketotifeno ® (EC); Ketotifeno Ecar ® (CO); Ketotifeno Genfar ® (EC); Ketotifeno MK ® (CO, CR, DO, GT, HN, PA, SV); Ketotifen-ratiopharm ® (DE, LU); Ketotifen Sanova ® (AT); Ketotifen Stada ® (DE); Ketotifen Temmler ® (DE); Ketotifen Trom ® (DE); Ketotiphar ® (BE); Ketotisan ® (AT); Ketotisin ® (CL); Kofen ® (BD); Licoften ® (CY); Medkofen ® (TH); Medotifen ® (TH); Nemesil ® (BR); Nortifen ® (ID); Novo-Ketotifen (CA); Pädiatifen ® (DE); Pehatifen ® (ID); Politifen ® (TH); Prevas ® (ID); Profilar ® (JO, RO); Profilas ® (ID); Profilasmin-Ped ® (BR); Profiten ® (IL); Prosma ® (BD); Quefeno ® (PT); Repinox ® (CL); Respimex ® (AR); Scanditen ® (ID); Sosefen ® (IT); Stamifen ® (IT); Sykofen ® (TH); Tenerel ® (CY, JO); Tifen ® (BR, EC); Tofen ® (BD); Totinal ® (EG, JO, KW, LB, SY); Ventisol ® (MX); Xidanef ® (TH); Zadetin ® (CL); Zadino ® (TH); Zaditen ® (AR, AT, BE, BR, CA, CH, CO, DE, DK, ES, FI, FR, GB, HK, HU, ID, IE, IL, IT, LU, MT, MX, NL, NO, PL, PT, RO, RU, SE, SG, TH, TR, ZA); Zaditor™ (CA); Zasten ® (ES, NZ); Zatofug ® (DE); Zetifen ® (RU); Zidex ® (CO); Zytofen ® (TH)

Xenalon Generic Name Spironolactone Online, Xenalon

Xenalon General Information

Xenalon - Pharmacology:

Xenalon is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Xenalon causes increased amounts of sodium and water to be excreted, while potassium is retained. Xenalon acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule.

Xenalon for patients

Patients who receive Aldactone should be advised to avoid potassium supplements and foods containing high levels of potassium including salt substitutes.

This description is suitable for active ingredient Spironolactone

Xenalon Interactions

ACE inhibitors: Concomitant administration of ACE inhibitors with potassium-sparing diuretics has been associated with severe hyperkalemia.

Alcohol, barbiturates, or narcotics: Potentiation of orthostatic hypotension may occur.

Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia, may occur.

Pressor amines (eg, norepinephrine): Xenalon reduces the vascular responsiveness to norepinephrine. Therefore, caution should be exercised in the management of patients subjected to regional or general anesthesia while they are being treated with Aldactone.

Skeletal muscle relaxants, nondepolarizing (eg, tubocurarine): Possible increased responsiveness to the muscle relaxant may result.

Lithium: Lithium generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.

Nonsteroidal anti-inflammatory drugs (NSAIDs): In some patients, the administration of an NSAID can reduce the diuretic, natriuretic, and antihypertensive effect of loop, potassium-sparing and thiazide diuretics. Combination of NSAIDs, eg, indomethacin, with potassium-sparing diuretics has been associated with severe hyperkalemia. Therefore, when Aldactone and NSAIDs are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

Digoxin: Xenalon has been shown to increase the half-life of digoxin. This may result in increased serum digoxin levels and subsequent digitalis toxicity. It may be necessary to reduce the maintenance and digitalization doses when spironolactone is administered, and the patient should be carefully monitored to avoid over - or underdigitalization.

Drug/Laboratory Test Interactions

Several reports of possible interference with digoxin radioimmunoassays by spironolactone, or its metabolites, have appeared in the literature. Neither the extent nor the potential clinical significance of its interference (which may be assay-specific) has been fully established.

Xenalon Contraindications

Aldactone is contraindicated for patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, or hyperkalemia.

This description is suitable for active ingredient Spironolactone

Generic name, Overdose, Half Life Xenalon, Food Interactions, Chemical, etc..

Cimoxen, Cimoxen

Ciprofloxacin

Antibacterial: Fluoroquinolone (gyrase inhibitor)

Chemical Name

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-

Foreign Names

Generic Names

Ciprofloxacin (OS: BAN, USAN, JAN)

Ciprofloxacine (OS: DCF)

Bay q 3939 (IS)

Ciprofloxacin Betaine (IS)

Ciprofloxacin (PH: BP 2016, Ph. Eur. 8, Ph. Int. 4, USP 38)

Ciprofloxacine (PH: Ph. Eur. 8)

Ciprofloxacinum (PH: Ph. Eur. 8, Ph. Int. 4)

Ciprofloxacin Hydrochloride (OS: USAN, BANM, JAN)

Bay o 9867 monohydrate (IS: Bayer)

UNII-4BA73M5E37 (IS)

Ciprofloxacin Hydrochloride (PH: BP 2016, Ph. Int. 4, USP 38)

Ciprofloxacin hydrochloride (PH: Ph. Eur. 8)

Ciprofloxacine (chlorhydrate de) (PH: Ph. Eur. 8)

Ciprofloxacinhydrochlorid (PH: Ph. Eur. 8)

Ciprofloxacini hydrochloridum (PH: Ph. Eur. 8, Ph. Int. 4)

Ciprofloxacin sulfate (IS)

Ciprofloxacin Lactate (OS: BANM)

Brand Names

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Buy Putaren - Diclofenac - Online Without Prescriptions, Putaren

Diclofenac (Putaren)

Diclofenac is used primarily for the treatment of inflammation and pain caused by conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is also effective in treating soft tissue inflammations due to tendinitis and bursitis, and treating dysmenorrhea (menstrual cramps). Diclofenac is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Diclofenac as directed by your doctor!

Take Diclofenac by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Diclofenac with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Diclofenac, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diclofenac.

Store Diclofenac at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do NOT use Diclofenac if:

you are allergic to any ingredient in Diclofenac or to bovine (cow) protein

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you have severe kidney problems

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if this applies to you.

Some medical conditions may interact with Diclofenac. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders (eg, porphyria), bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you smoke, drink alcohol, or have a history of alcohol abuse

if you are taking an antibiotic or an anti-seizure medicine. The risk of liver problems may be increased with some of these medicines.

Some medicines may interact with Diclofenac. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), heparin and other blood thinners (eg, dalteparin), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Acetaminophen because the risk of liver problems may be increased

Probenecid because it may increase the risk of Diclofenac's side effects

Cyclosporine, lithium, metformin, methotrexate, oral NSAIDs (eg, ibuprofen), or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Diclofenac

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Diclofenac.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diclofenac may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Diclofenac may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Diclofenac. Taking it in high doses, for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Diclofenac with food will NOT reduce the risk of these effects. If you have severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling, contact your doctor or emergency room right away.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Diclofenac is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Diclofenac unless your doctor tells you to.

Check with your doctor or pharmacist before you take acetaminophen while you are taking Diclofenac. The risk of liver problems may be increased.

Do not switch between different forms of Diclofenac (eg, enteric-coated tablets, immediate-release tablets, capsules) unless your doctor tells you to. They may not provide the same amount of medicine to your body.

Lab tests, including kidney function, liver function, blood electrolyte levels, complete blood cell counts, and blood pressure, may be performed while you use Diclofenac. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Diclofenac with caution in the elderly; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.

Diclofenac should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Diclofenac may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breastfeed while taking Diclofenac.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; headache; mild stomach pain or heartburn; nausea; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; persistent flu-like symptoms; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting or diarrhea; shortness of breath; sudden or unexplained weight gain; swelling of the hands, legs, or feet; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, yellowing of the skin or eyes); unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Diclofenac (Putaren)

Diclofenac is used primarily for the treatment of inflammation and pain caused by conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is also effective in treating soft tissue inflammations due to tendinitis and bursitis, and treating dysmenorrhea (menstrual cramps). Diclofenac is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Diclofenac as directed by your doctor!

Take Diclofenac by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Diclofenac with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Diclofenac, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diclofenac.

Store Diclofenac at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do NOT use Diclofenac if:

you are allergic to any ingredient in Diclofenac or to bovine (cow) protein

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you have severe kidney problems

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if this applies to you.

Some medical conditions may interact with Diclofenac. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders (eg, porphyria), bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you smoke, drink alcohol, or have a history of alcohol abuse

if you are taking an antibiotic or an anti-seizure medicine. The risk of liver problems may be increased with some of these medicines.

Some medicines may interact with Diclofenac. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), heparin and other blood thinners (eg, dalteparin), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Acetaminophen because the risk of liver problems may be increased

Probenecid because it may increase the risk of Diclofenac's side effects

Cyclosporine, lithium, metformin, methotrexate, oral NSAIDs (eg, ibuprofen), or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Diclofenac

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Diclofenac.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diclofenac may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Diclofenac may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Diclofenac. Taking it in high doses, for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Diclofenac with food will NOT reduce the risk of these effects. If you have severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling, contact your doctor or emergency room right away.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Diclofenac is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Diclofenac unless your doctor tells you to.

Check with your doctor or pharmacist before you take acetaminophen while you are taking Diclofenac. The risk of liver problems may be increased.

Do not switch between different forms of Diclofenac (eg, enteric-coated tablets, immediate-release tablets, capsules) unless your doctor tells you to. They may not provide the same amount of medicine to your body.

Lab tests, including kidney function, liver function, blood electrolyte levels, complete blood cell counts, and blood pressure, may be performed while you use Diclofenac. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Diclofenac with caution in the elderly; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.

Diclofenac should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Diclofenac may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breastfeed while taking Diclofenac.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; headache; mild stomach pain or heartburn; nausea; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; persistent flu-like symptoms; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting or diarrhea; shortness of breath; sudden or unexplained weight gain; swelling of the hands, legs, or feet; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, yellowing of the skin or eyes); unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Buy Aciklam - Online Without Prescriptions, Aciklam

Aciclovir (Aciklam)

Aciclovir is indicated for the treatment of HSV and VZV infections, including:

Genital herpex simplex

Herpes simplex labialis

Herpes zoster (shingles)

Acute chickenpox in immunocompromised patients

Herpes simplex encephalitis

Acute mucocutaneous HSV infections in immunocompromised patients

Herpes simplex keratitis (ocular herpes)

Herpes simplex blepharitis

Bell's Palsy

Aciclovir is an antiviral. It works by stopping viral replication. However, Aciclovir does not eliminate the virus, is not a cure, and does not prevent transmission to others.

Use Aciclovir as directed by your doctor!

Take Aciclovir by mouth with or without food.

Start therapy with Aciclovir at the earliest sign or symptom of shingles or genital herpes (pain, burning, blisters).

If treating an acute outbreak, continue using Aciclovir for the full course of treatment even if you feel better in a few days.

For suppressive therapy, Aciclovir works best if it is taken at the same times each day.

If you miss a dose of Aciclovir, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Aciclovir.

Store Aciclovir at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aciclovir out of the reach of children and away from pets.

Do NOT use Aciclovir if:

you are allergic to any ingredient in Aciclovir or to valacyclovir

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Aciclovir. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney problems or a weakened immune system.

Some medicines may interact with Aciclovir. Tell your health care provider if you are taking any other medicine, especially any of the following:

Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aciclovir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Aciclovir may cause drowsiness, dizziness, vision changes, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Aciclovir with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Aciclovir may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit down or stand up slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Aciclovir may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Aciclovir. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Aciclovir is not a cure for genital herpes and will not prevent the virus from spreading. Avoid sexual intercourse when sores are present to prevent infecting your partner. You can also be contagious and spread the herpes virus but not have any signs or symptoms at all. This is called asymptomatic viral shedding.

Lab tests, including kidney function and serum urea nitrogen (BUN), may be performed while you use Aciclovir. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Aciclovir with caution in the elderly; they may be more sensitive to its effects, especially confusion, drowsiness, or hallucinations.

Aciclovir is not recommended for use in children younger than 2 years old as safety and effectiveness for children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Aciclovir while you are pregnant. Aciclovir is found in breast milk. If you are or will be breast-feeding while you use Aciclovir, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; general body discomfort; headache; nausea/vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); aggressive behavior; blood in the urine; confusion; decreased consciousness; decreased urination; hallucinations; lower back pain; mental or mood changes; red, swollen, blistered, or peeling skin; seizures; unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Aciclovir (Aciklam)

Aciclovir is indicated for the treatment of HSV and VZV infections, including:

Genital herpex simplex

Herpes simplex labialis

Herpes zoster (shingles)

Acute chickenpox in immunocompromised patients

Herpes simplex encephalitis

Acute mucocutaneous HSV infections in immunocompromised patients

Herpes simplex keratitis (ocular herpes)

Herpes simplex blepharitis

Bell's Palsy

Aciclovir is an antiviral. It works by stopping viral replication. However, Aciclovir does not eliminate the virus, is not a cure, and does not prevent transmission to others.

Use Aciclovir as directed by your doctor!

Take Aciclovir by mouth with or without food.

Start therapy with Aciclovir at the earliest sign or symptom of shingles or genital herpes (pain, burning, blisters).

If treating an acute outbreak, continue using Aciclovir for the full course of treatment even if you feel better in a few days.

For suppressive therapy, Aciclovir works best if it is taken at the same times each day.

If you miss a dose of Aciclovir, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Aciclovir.

Store Aciclovir at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aciclovir out of the reach of children and away from pets.

Do NOT use Aciclovir if:

you are allergic to any ingredient in Aciclovir or to valacyclovir

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Aciclovir. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney problems or a weakened immune system.

Some medicines may interact with Aciclovir. Tell your health care provider if you are taking any other medicine, especially any of the following:

Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aciclovir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Aciclovir may cause drowsiness, dizziness, vision changes, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Aciclovir with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Aciclovir may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit down or stand up slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Aciclovir may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Aciclovir. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Aciclovir is not a cure for genital herpes and will not prevent the virus from spreading. Avoid sexual intercourse when sores are present to prevent infecting your partner. You can also be contagious and spread the herpes virus but not have any signs or symptoms at all. This is called asymptomatic viral shedding.

Lab tests, including kidney function and serum urea nitrogen (BUN), may be performed while you use Aciclovir. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Aciclovir with caution in the elderly; they may be more sensitive to its effects, especially confusion, drowsiness, or hallucinations.

Aciclovir is not recommended for use in children younger than 2 years old as safety and effectiveness for children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Aciclovir while you are pregnant. Aciclovir is found in breast milk. If you are or will be breast-feeding while you use Aciclovir, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; general body discomfort; headache; nausea/vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); aggressive behavior; blood in the urine; confusion; decreased consciousness; decreased urination; hallucinations; lower back pain; mental or mood changes; red, swollen, blistered, or peeling skin; seizures; unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Arimidex Uses, Dosage, Side Effects, Imidex

Arimidex

What is Arimidex?

Arimidex (anastrozole) lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

Arimidex is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).

Arimidex may also be used for purposes not listed in this medication guide.

Important information

Do not use Arimidex if you are pregnant. It could harm the unborn baby.

Arimidex may not work as well if you take it together with estrogen medication (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings).

Arimidex may increase your risk of a stroke or blood clot. Call your doctor at once if you have sudden numbness or weakness, (especially on one side of the body), sudden severe headache, slurred speech, or problems with vision or balance.

Before taking this medicine

You should not use Arimidex if you are allergic to anastrozole, if you are breast-feeding a baby, or if you have not yet completed menopause. Arimidex is not for use in men or children.

To make sure Arimidex is safe for you, tell your doctor if you have:

a history of stroke or blood clot;

severe liver disease;

high cholesterol; or

osteoporosis or low bone mineral density.

Arimidex can decrease bone mineral density, which may increase your risk of developing osteoporosis. Your bone mineral density may need to be tested before and during treatment with anastrozole.

Although it is not likely that a postmenopausal woman would be pregnant, anastrozole could harm an unborn baby. Do not take this medicine if you are pregnant or may become pregnant. Use effective birth control if you are not past menopause, and tell your doctor right away if you become pregnant during treatment.

It is not known whether anastrozole passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using Arimidex.

You may need to take a pregnancy test before using Arimidex, to make sure you are not pregnant.

How should I take Arimidex?

Arimidex is usually taken once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take Arimidex with or without food.

You may need to keep taking this medication for up to 5 years. Follow your doctor's instructions.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Anastrozole can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Arimidex side effects

Get emergency medical help if you have any signs of an allergic reaction to Arimidex: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

shortness of breath (even with mild exertion), swelling, rapid weight gain;

a bone fracture;

liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; or

severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Arimidex side effects may include:

weakness, hot flashes;

numbness or tingly feeling in your skin;

swelling in your ankles or feet;

joint pain or stiffness, problems with your fingers while gripping;

sore throat, headache, back pain, bone pain;

depression, mood changes, sleep problems (insomnia);

high blood pressure (severe headache, blurred vision, pounding in your neck or ears);

nausea, vomiting; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Arimidex?

Arimidex may not work as well if you take it together with an estrogen medication (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings). Before you start taking Arimidex, tell your doctor if you also take tamoxifen or estrogen.

Other drugs may interact with Arimidex, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

More about Arimidex (anastrozole)

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about Arimidex.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Arimidex only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 6.07. Revision Date: 2015-10-21, 9:18:58 AM.

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Fosinopril - Side Effects, Dosage, Interactions, Fosinopril

Fosinopril

Fosinopril is a prescription medicine used to treat high blood pressure and heart failure.

The drug used to be sold under the brand name Monopril, but this brand is no longer available.

Lowering your blood pressure can reduce your risk of having a heart attack, a stroke, or another heart complication.

Fosinopril belongs to a class of drugs called angiotensin converting enzyme (ACE) inhibitors. It works by helping relax blood vessels.

The U. S. Food and Drug Administration (FDA) approved fosinopril in 1991. It's made and marketed by various pharmaceutical companies.

Fosinopril Warnings

Before taking fosinopril, tell your doctor if you have, or have ever had:

Heart disease, heart failure, a heart attack, or other heart problems

Liver disease

Kidney disease or a kidney transplant

Stroke

Lupus (an autoimmune disease characterized by inflammation and a variety of symptoms)

Bone marrow problems

Diabetes

Scleroderma (a skin condition)

Rheumatoid arthritis

An electrolyte imbalance

Angioedema (swelling of the face, lips, tongue, throat, arms, or legs)

Allergies to medication (especially ACE inhibitors)

Also, let your doctor know if you have diabetes and are taking the medicine Tekturna (aliskiren) or Amturnide (aliskiren, amlodipine, and hydrochlorothiazide).

Fosinopril may affect your blood sugar levels if you have diabetes. Be sure to monitor your condition carefully.

Tell your healthcare provider you're using fosinopril before having any type of medical test or surgery, including a dental procedure.

Excessive sweating, vomiting, diarrhea, or dehydration could increase your risk of low blood pressure. Tell your doctor if you experience any of these conditions.

Use caution when exercising or experiencing hot weather.

Fosinopril may cause you to sunburn more easily. Avoid unnecessary exposure to sunlight, and use sunscreen and wear protective clothing when outdoors.

Your doctor may recommend following a diet and exercise plan while taking fosinopril. You may also be told to drink more fluids. Follow these instructions carefully.

Don't take potassium or salt substitutes while using fosinopril unless your healthcare provider tells you to do so.

Keep all appointments with your doctor and laboratory while taking this medicine. You'll need to undergo frequent tests, including blood pressure checks.

This medicine may be less effective and increase the risk of angioedema in people of African descent. Talk to your doctor if this is a concern.

Pregnancy and Fosinopril

Fosinopril contains a black box warning because it may cause harm or death to an unborn baby if taken during pregnancy.

Tell your doctor right away if you become pregnant while taking fosinopril.

Use an effective form of birth control to prevent pregnancy while taking this medicine.

This drug passes into breast milk. Don't breastfeed a baby while using fosinopril.

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Not only that, but your sites get cached, speeding it up quite a bit. Interested? Visit https://sucuri. net/website-firewall

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Phylobid-200mg Tab Price, Side-Effects, Uses Generic-Alternatives & Dosage Of Phylobid-200mg Tab In

LIPAGLYN 4 mg. Pack of 10 Tablets

Side Effects of Phylobid-200mg Tab:

Nausea, vomiting, abdominal pain, diarrhoea, headache, insomnia, dizziness, anxiety, restlessness, tremor, palpitations. Potentially Fatal: Convulsions, cardiac arrhythmias, hypotension and sudden death after too rapid IV inj.

Drug Interactions of Phylobid-200mg Tab:

Other xanthines. Theophylline clearance reduced by high dose allopurinol, some antiarrhythmics, cimetidine, disulfiram, propranolol, methotrexate, aciclovir, mexiletine, pentoxifylline, tacrine, ticlopidine, fluvoxamine, interferon-?, macrolide antibiotics, quinolones, oral contraceptives, thiabendazole and viloxazine. Theophylline clearance increased by phenytoin, anticonvulsants, ritonavir, rifampicin, sulfinpyrazone, aminoglutethimide, barbiturates, ipriflavone, cigarette smoking. Concurrent use decreased lithium, alprazolam levels. Increased risk of arrhythmias with ephedrine, sympathomimetic, general anaesthetics. Increased heart rate with tadalafil.

Contraindications of Phylobid-200mg Tab:

Hypersensitivity to xanthine derivatives, porphyria

Mechanism of Action of Phylobid-200mg Tab:

Theophylline competitively blocks phosphodiesterase which increases cAMP tissue concentrations causing bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion. Absorption: Rapid and completely absorbed following oral and rectal (enemas) administration, slow after rectal (suppositories) and IM administration. Food delays rate but not extent of absorption. Peak serum concentrations: 1-2 hr (liquid, capsules or uncoated tablets); 4 hr (modified-release preparations). Distribution: Rapidly distributed throughout extracellular fluids and body tissues. Crosses the placenta and enters breast milk. Protein binding: 40%. Metabolism: Hepatic metabolism via cytochrome P450 isoenzyme CYP1A2, CYP2E1 and CYP3A3. Serum half-life: 6-12 hr (healthy, non-smoking asthmatic adult); 1-5 hr (children); 4-5 hr (cigarette smokers); 10-45 hr (neonates and premature infants). Excretion: Via urine as metabolites and unchanged drug; small amount via faeces as unchanged drug

Special Precautions for Phylobid-200mg Tab:

Admin IV inj very slowly to avoid direct stimulation of the CNS and CVS. Cardiac failure, hypertension, epilepsy, hyperthyroidism, history of peptic ulcer disease, renal or hepatic dysfunction, glaucoma, DM, severe hypoxaemia, chronic alcoholism, acute febrile illness. On influenza immunization or active influenza infection, COPD and cor pulmonale. Smokers may need higher dose. Pregnancy, lactation, children and elderly.

Categories

Progerin, Telomeres And New Clues About Aging, Progeron

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A new study offers insights about the interaction between a toxic protein called progerin and telomeres, which cap the ends of chromosomes like aglets, the plastic tips that bind the ends of shoelaces.

Telomeres wear away during cell division. When they degrade sufficiently, the cell stops dividing and dies. The researchers have found that short or dysfunctional telomeres activate production of progerin, which is associated with age-related cell damage. As the telomeres shorten, the cell produces more progerin.

Progerin is a mutated version of a normal cellular protein called lamin A, which is encoded by the normal LMNA gene. Lamin A helps to maintain the normal structure of a cell's nucleus, the cellular repository of genetic information.

In 2003, NHGRI researchers discovered that a mutation in LMNA causes the rare premature aging condition, progeria, formally known as known as Hutchinson-Gilford progeria syndrome. Progeria is an extremely rare disease in which children experience symptoms normally associated with advanced age, including hair loss, diminished subcutaneous fat, premature atherosclerosis and skeletal abnormalities. These children typically die from cardiovascular complications in their teens.

"Connecting this rare disease phenomenon and normal aging is bearing fruit in an important way," said NIH Director Francis S. Collins, M. D. Ph. D. a senior author of the current paper. "This study highlights that valuable biological insights are gained by studying rare genetic disorders such as progeria. Our sense from the start was that progeria had a lot to teach us about the normal aging process and clues about more general biochemical and molecular mechanisms."

Collins led the earlier discovery of the gene mutation responsible for progeria and subsequent advances at NIH in understanding the biochemical and molecular underpinnings of the disease.

In a 2007 study, NIH researchers showed that normal cells of healthy people can produce a small amount of progerin, the toxic protein, even when they do not carry the mutation. The more cell divisions the cell underwent, the shorter the telomeres and the greater the production of progerin. But a mystery remained: What was triggering the production of the toxic progerin protein?

The current study shows that the mutation that causes progeria strongly activates the splicing of lamin A to produce the toxic progerin protein, leading to all of the features of premature aging suffered by children with this disease. But modifications in the splicing of LMNA are also at play in the presence of the normal gene.

The research suggests that the shortening of telomeres during normal cell division in individuals with normal LMNA genes somehow alters the way a normal cell processes genetic information when turning it into a protein, a process called RNA splicing. To build proteins, RNA is transcribed from genetic instructions embedded in DNA. RNA does not carry all of the linear information embedded in the ribbon of DNA; rather, the cell splices together segments of genetic information called exons that contain the code for building proteins, and removes the intervening letters of unused genetic information called introns. This mechanism appears to be altered by telomere shortening, and affects protein production for multiple proteins that are important for cytoskeleton integrity. Most importantly, this alteration in RNA splicing affects the processing of the LMNA messenger RNA, leading to an accumulation of the toxic progerin protein.

Cells age as part of the normal cell cycle process called senescence, which progressively advances through a limited number of divisions in the cell lifetime. "Telomere shortening during cellular senescence plays a causative role in activating progerin production and leads to extensive change in alternative splicing in multiple other genes," said lead author Kan Cao, Ph. D. an assistant professor of cell biology and molecular genetics at the University of Maryland, College Park.

Telomerase is an enzyme that can extend the structure of telomeres so that cells continue to maintain the ability to divide. The study supplied support for the telomere-progerin link, showing that cells that have a perpetual supply of telomerase, known as immortalized cells, produce very little progerin RNA. Most cells of this kind are cancer cells, which do not reach a normal cell cycle end point, and instead replicate out of control.

The researchers also conducted laboratory tests on normal cells from healthy individuals using biochemical markers to indicate the occurrence of progerin-generating RNA splicing in cells. The cell donors ranged in age from 10 to 92 years. Regardless of age, cells that passed through many cell cycles had progressively higher progerin production. Normal cells that produce higher concentrations of progerin also displayed shortened and dysfunctional telomeres, the tell-tale indication of many cell divisions.

In addition to their focus on progerin, the researchers conducted the first systematic analysis across the genome of alternative splicing during cellular aging, considering which other protein products are affected by jumbled instructions as RNA molecules assemble proteins through splicing. Using laboratory techniques that analyze the order of chemical units of RNA, called nucleotides, the researchers found that splicing is altered by short telomeres, affecting lamin A and a number of other genes, including those that encode proteins that play a role in the structure of the cell.

The researchers suggest that the combination of telomere fraying and loss with progerin production together induces cell aging and may lend insights into how progerin may participate in the normal aging process.

Journal of Clinical Investigation

Niacin Detox – Niacin For Drug Detoxification, Fiacin

Drug Detox Rehab and Program

Niacin is an organic compound made up of chemical substances which have the ability to dilate blood vessels and help improve blood circulation. Not only can Niacin help lower cholesterol, but it can also help in the detoxification of the body. Niacin detox can be a very effective method of ridding the body of all its toxins. When toxins accumulate in a person’s body, they are usually stored in the fat cells. Their several different ways the body can be exposed to toxins. Over exposure to the sun can actually be toxic. There are toxins in water and food that the body will absorb and store. Any sort of drugs, whether they are legal or illegal, contain toxins which will be stored in the body. These toxins will build up in the fatty tissues and removing the toxins can be very difficult. The Nicotinic acid in niacin has the ability to dilate the capillaries, surrounding the fatty tissues. When these capillaries are dilated, they can reach the fatty tissue and possibly flush out the toxins which are stored in the fat cells. This process is known as the niacin drug detox program.

In the niacin for drug detox program, individuals are giving large amounts of niacin, followed by a brief period of exercise. The exercise is used to increase the body’s heart rate which helps spread the niacin throughout the body. After a brief period of exercise, the individual then enters a sauna. In the sauna, a person’s body will sweat heavily. The person should stay in the sauna for approximately three to four hours a day. While in the sauna, a person should drink plenty of water to replace the water they will be sweating out. A person should periodically take showers to wash away the sweat. This helps prevent the toxins in the sweat from being reabsorbed into the body. As the Niacin breaks down the toxins stored in the fatty tissue, the sauna will force the toxins out of the body by way of sweating. The person should ingest different types of healthy, high quality oils which will help replace the toxic fat cells being removed. Releasing the toxins from the fat cells is made easier when given these oils. A person going through a niacin detoxification program should have a healthy diet consisting of large amounts of fruits and vegetables. The Niacin detoxification program can be a very effective way to rid the body of and toxins. Before taking part in a niacin for detox program, a person should check with a doctor to make sure that they are healthy enough to partake in these strenuous activities.

A lifetime of exposure to toxic materials and chemicals can cause the human body to become unhealthy and unclean. A person’s body can be ridded of all toxins by taking part in a niacin detox. A niacin detox is a healthy, natural way to rid the body of any toxins stored in the fatty tissues.

Saas Application To Detect And Resolve Suspicious Activityfintel, Fintel

How It Works

Why should my financial institution use Fintel?

Fintel should be used if your financial institution desires to engage in greater information sharing of data related to fraud, money laundering, cyber threats and terrorist financing, particularly by using legal protections from any civil liability for disclosing information to another financial institution. Fintel allows your financial institution to exchange information more efficiently and gain greater insight and value from the data that both you and other users already capture and retain. Your financial institution will be part of a network so that other institutions may efficiently contact you and potentially alert you to information and intelligence you may otherwise have not been aware of, and vice versa.

How do we sign up for Fintel?

Fintel is currently in private beta. To learn more about how you can participate please click here .

How is Fintel compliant with bank secrecy and privacy laws?

Fintel software is engineered to help ensure compliance with all laws and regulations, and where applicable, leverage the safe harbor protections afforded under federal law.

How is my financial institution’s data protected?

We maintain appropriate administrative, physical, and technical safeguards for protection of the security, confidentiality and integrity of your data.

Can we share information about fraud, including customer information, using Fintel?

Yes. Although typically the Gramm-Leach-Bliley Act (GLBA) protects the privacy of customer financial information and restricts when financial institutions may disclose personal financial information to nonaffiliated third parties the GLBA also provides exceptions under which financial institutions may share customer information with a nonaffiliated third party.

GLBA provides that the privacy requirements for initial notice, opt out, and for service providers and joint marketing do not apply when a financial institution discloses nonpublic personal information “to protect against or prevent actual or potential fraud, unauthorized transactions, claims, or other liabilities.”

Can we share information about money laundering or terrorist financing, including customer information, using Fintel?

Yes. Financial institutions may share customer information about money laundering and terrorist financing with nonaffiliated third parties to protect against, actually or potentially, engaging in unauthorized transaction or customer relationships that may expose a financial institution to liability under the Bank Secrecy Act or USA PATRIOT Act.

What type of information is protected by the USA PATRIOT Act Section 314(b) through use of Fintel?

In order for the communication with any third party to be covered by the USA PATRIOT Act civil liability safe harbor protections a number of factors must be met that the Fintel application assists you in navigating: 1) All parties sharing consumer information must either a financial institutions or associations of financial institutions; 2) All parties must be registered with FinCEN to participate in voluntary information sharing; 3) The information must be related to actual or potential money laundering or terrorist. This includes fraud related transactions involving the proceeds of specified unlawful activity.

Who makes the final decision about whether information can be shared?

Fintel’s software is designed to provide guidance about what may or may not be shared and what is covered under the safe harbor. Ultimately, the parties to the communication need to make the decisions.

What type of liability might my financial institution face by using Fintel?

You should consult with your legal and compliance department before beginning to use Fintel, but generally you are exposed to the same type of risks that would occur anytime your institution engages in the sharing of data with an unaffiliated third party financial institution and/or through a relationship with a service or technology provider.

Tractonorm Lax, Tractonorm Lax

Duphalac is used to treat chronic constipation.

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

The liquid form of lactulose may become slightly darken in color, but this is a harmless effect. However, do not use the medicine if it becomes very dark, or if it gets thicker or thinner in texture.

Lactulose powder should be mixed with at least 4 ounces of water. You may also use fruit juice or milk to make the medication better.

It may take up to 48 hours before you have a bowel movement after taking lactulose.

If you use lactulose over a long period of time, your doctor may want you to have occasional blood tests. Do not miss any scheduled appointments.

If you missed a dose - take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

Take this medication exactly as prescribed by your Health Provider.

Store at the room temperature away from moisture and sunlight. Keep out of reach of children and pets.

Lactulose is a type of sugar. It is broken down in the large intestine into mild acids that draw water into the colon, which helps soften the stools.

You should not use this medication if you are on a special diet low in galactose (milk sugar).

Before taking lactulose, tell your doctor if you have diabetes or if you need to have any type of intestinal test using a scope (such as a colonoscopy).

Stop using lactulose and call your doctor at once if you have severe or ongoing diarrhea.

The liquid form of lactulose may become slightly darken in color, but this is a harmless effect. However, do not use the medicine if it becomes very dark, or if it gets thicker or thinner in texture.

If you use lactulose over a long period of time, your doctor may want you to have occasional blood tests. Do not miss any scheduled appointments.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether lactulose passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Avoid using antacids without your doctor's advice. Use only the specific type of antacid your doctor recommends. Antacids contain different medicines and some types can make it harder for your body to absorb lactulose.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using lactulose and call your doctor at once if you have severe or ongoing diarrhea.

Less serious side effects may include: bloating, gas; stomach pain; diarrhea; or nausea, vomiting.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

Carvedilol Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Carvid

carvedilol

GENERIC NAME(S): CARVEDILOL

Warnings

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when you suddenly stop this drug. Some people who have suddenly stopped taking similar drugs have had chest pain. heart attack. and irregular heartbeat. If your doctor decides you should no longer use this drug, he or she may direct you to gradually decrease your dose over 1 to 2 weeks.

When gradually stopping this medication, it is recommended that you temporarily limit physical activity to decrease strain on the heart. Get medical help right away if you develop chest pain/tightness/pressure, chest pain spreading to the jaw/neck/arm, unusual sweating. trouble breathing. or fast/irregular heartbeat.

Uses

This drug works by blocking the action of certain natural substances in your body, such as epinephrine. on the heart and blood vessels. This effect lowers your heart rate. blood pressure. and strain on your heart. Carvedilol belongs to a class of drugs known as alpha and beta blockers .

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat a certain type of irregular heartbeat (atrial fibrillation ).

How to use carvedilol

See also Warning section.

Read the Patient Information Leaflet if available from your pharmacist before you start taking carvedilol and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with food as directed by your doctor, usually twice daily.

The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

For the treatment of high blood pressure. it may take 1 to 2 weeks before you get the full benefit of this drug. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings remain high or increase, or you have worsening symptoms of heart failure like increased shortness of breath).

Side Effects

See also Warning and Precautions sections.

Dizziness. lightheadedness, drowsiness, diarrhea. impotence, or tiredness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. The risk of dizziness is highest within 1 hour after you take your dose. Taking this medication with food and starting treatment with a low dose and slowly increasing your dose as directed by your doctor help to reduce the risk of dizziness.

This drug may reduce blood flow to your hands and feet, causing them to feel cold. Smoking may worsen this effect. Dress warmly and avoid tobacco use.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: very slow heartbeat, severe dizziness, fainting. unusual weakness. signs of kidney problems (such as change in the amount of urine), numbness/tingling of the hands/feet, blue fingers/toes, easy bruising/bleeding, mental/mood changes (such as confusion, depression ), seizures .

Although this medication may be used to treat heart failure, some people may rarely develop new or worsening symptoms of heart failure, especially at the start of carvedilol treatment. Tell your doctor right away if you develop any of these serious side effects: swelling of the hands/ankles /feet, severe tiredness, shortness of breath, unexplained/sudden weight gain .

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking carvedilol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain types of heartbeat/heart rhythm problems (such as slow/irregular heartbeat, sick sinus syndrome. second - or third-degree atrioventricular block), breathing problems (such as asthma, chronic bronchitis. emphysema), severe heart failure requiring hospitalization, liver disease, kidney disease, blood circulation problems (such as Raynaud's disease, peripheral vascular disease), serious allergic reactions including those needing treatment with epinephrine, overactive thyroid disease (hyperthyroidism), a certain type of tumor (pheochromocytoma), other heart problems (such as Prinzmetal's variant angina), a certain muscle disease (myasthenia gravis), certain eye problems (cataracts, glaucoma).

This drug may make you dizzy, drowsy, or cause you to faint. This is most likely to occur within 1 hour after taking your dose, especially when you start carvedilol treatment or any time your doctor increases your dose. During these periods, avoid driving and doing hazardous tasks. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

If you have diabetes, this product may prevent the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness and sweating, are unaffected by this drug. This product also may make it harder to control your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst, hunger, and urination. Your doctor may need to adjust your diabetes medication or diet.

People who wear contact lenses may have dry eyes while taking this medication.

Before having surgery (including cataract/glaucoma eye surgery), tell your doctor or dentist if you are taking or have ever taken this medication, and about all the other products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially dizziness and lightheadedness.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details.

It is unknown if carvedilol passes into breast milk. However, it is unlikely to pass into breast milk in large amounts. There is a low risk that it may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

One product that may interact with this drug is: fingolimod.

Check the labels on all your medicines (such as cough-and-cold products, diet aids, or NSAIDs such as ibuprofen, naproxen) because they may contain ingredients that could increase your blood pressure/heart rate or worsen your heart failure. Ask your pharmacist for more details.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: very slow heartbeat, severe dizziness, fainting, slow/shallow breathing, seizures.

Notes

Do not share this medication with others.

Lifestyle changes that may help this medication work better include exercising, stopping smoking, and eating a low-cholesterol/low-fat diet. Consult your doctor for more details.

Have your blood pressure and pulse (heart rate) checked regularly while taking this medication. Learn how to monitor your own blood pressure and pulse at home, and share the results with your doctor.

Laboratory and/or medical tests (such as kidney and liver function tests) should be performed periodically to monitor your progress or check for side effects.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised April 2016. Copyright(c) 2016 First Databank, Inc.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Doxazosin (Cardura) Uses, Dosage, Side Effects, Dozozin

Doxazosin

Doxazosin is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. It relaxes your veins and arteries so that blood can more easily pass through them. It also relaxes the muscles in the prostate and bladder neck, making it easier to urinate.

Doxazosin is used to treat hypertension (high blood pressure), or to improve urination in men with benign prostatic hyperplasia (enlarged prostate).

Doxazosin may also be used for purposes not listed in this medication guide.

Important information

Doxazosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using doxazosin. Do not stop using this medicine before surgery unless your surgeon tells you.

You should not use this medication if you are allergic to doxazosin or similar medicines such as alfuzosin (Uroxatral), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin). Doxazosin may cause dizziness or fainting, especially when you first start taking it or when you start taking it again. Be careful if you drive or do anything that requires you to be alert. Avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Tell your doctor about all other medications you use, especially other blood pressure medications including diuretics (water pills).

Before taking this medicine

You should not use this medicine if you are allergic to doxazosin or similar medicines such as alfuzosin (Uroxatral), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin).

To make sure doxazosin is safe for you, tell your doctor if you have:

a blockage in your digestive tract (stomach or intestines);

liver disease; or

low blood pressure.

Doxazosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using this medicine before surgery unless your surgeon tells you to.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether doxazosin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take doxazosin?

Take doxazosin exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Doxazosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it, or when you start taking it again.

You may feel very dizzy when you first wake up. Be careful when standing or sitting up from a lying position.

Call your doctor if you have severe dizziness or feel like you might pass out.

While using doxazosin, your blood pressure or prostate may need to be checked often.

If you stop taking doxazosin for any reason, ask your doctor before you start taking it again. You may need a dose adjustment.

If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

If you miss your doses for several days in a row, call your doctor before restarting the medication. You may need a lower dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme dizziness or fainting.

What should I avoid while taking doxazosin?

Doxazosin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

To prevent dizziness, avoid standing for long periods of time or becoming overheated during exercise and in hot weather.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Drinking alcohol with this medicine can cause side effects.

Doxazosin side effects

Get emergency medical help if you have signs of an allergic reaction to doxazosin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

severe ongoing stomach pain or bloating;

new or worsening chest pain;

trouble breathing; or

a penis erection that is painful or lasts 4 hours or longer.

Common doxazosin side effects may include:

low blood pressure, dizziness;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Doxazosin dosing information

Usual Adult Dose for Hypertension:

Initial dose: 1 mg orally once a day. Maintenance dose: 1 to 16 mg orally once a day.

Usual Adult Dose for Benign Prostatic Hyperplasia:

Initial dose: Immediate-release: 1 mg orally once a day. Extended-release: 4 mg orally once a day with breakfast

Maintenance dose: Immediate-release: 1 to 8 mg orally once a day. Extended-release: 4 to 8 mg orally once a day with breakfast. Depending on the patient's symptomatic response and tolerability, the dose may be increased to 8 mg (the maximum recommended dose). The recommended titration interval is 3 to 4 weeks.

If switching from immediate-release doxazosin tablets to extended-release tablets, therapy should be initiated with the lowest dose (4 mg once daily). Prior to starting therapy with doxazosin extended-release tablets, the final evening dose of immediate-release tablets should not be taken. If doxazosin extended-release tablets are discontinued for several days, therapy should be restarted using the 4 mg once daily dose.

Usual Geriatric Dose for Hypertension:

Initial dose: 0.5 mg orally once a day.

What other drugs will affect doxazosin?

Tell your doctor about all your current medicines and any you start or stop using, especially:

medicine to treat HIV or AIDS; or

sildenafil (Viagra) or other erectile dysfunction medicines.

This list is not complete. Other drugs may interact with doxazosin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

More about doxazosin

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about doxazosin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use doxazosin only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 8.01. Revision Date: 2015-11-16, 3:09:59 PM.

Drug Status

Capace 25 - Mg Tablets, Capace

PROPRIETARY NAME: (and dosage form)

CAPACE 25 mg Tablets

COMPOSITION: CAPACE 25 mg tablets contain 25 mg D-3-mercapto-2-methylpropanoyl-L-proline ( Captopril ).

PHARMACOLOGICAL CLASSIFICATION: Category A 7 1 Vasodilator, hypotensive medicine.

PHARMACOLOGICAL ACTION: Although the mechanism of action of CAPACE has not yet been fully elucidated, its effects appear to result primarily from suppression of the renin-angiotensin-aldosterone system. However, there is no consistent correlation between renin levels and response to the drug. Renin, an enzyme synthesised by the kidney into the circulation where it acts on a plasma globulin substrate to produce angiotensin I, a relatively inactive decapeptide. Angiotensin I is then converted enzymatically by angiotensin-converting enzyme (ACE) to the octapeptide angiotensin II, one of the most potent endogenous vasoconstrictor substances. Angiotensin II also stimulates aldosterone secretion from the adrenal cortex, thereby contributing to sodium and fluid retention and potassium loss. CAPACE prevents the conversion of angiotensin I to angiotensin II by inhibition of ACE and this is reflected by a decrease in the pressor substance, angiotensin II, and an increase in plasma renin activity (PRA). The latter is due to the relative lack of negative feedback on the renin release caused by reduction in angiotensin II. Decreased concentrations of aldosterone are found in blood and urine, and as a result, small increases in serum potassium may occur along with sodium and fluid loss. Following oral administration of CAPACE, rapid absorption occurs with peak blood levels at about one hour. The average minimal absorption is approximately 75 percent. The presence of food in the gastro-intestinal tract reduces absorption by about 30 to 40 percent. Only 25 to 30 percent of the drug is bound to plasma proteins. The apparent elimination half-life in blood is about 4 hours for the 4 to 12-hour time interval. The half-life of unchanged drug is approximately 2 hours. About 75 percent of a dose of CAPACE is excreted in the urine (of which 50 percent is unchanged drug and the remainder conjugates with endogenous thiol compounds, e. g. captopril-cysteine and the disulfide dimer of the parent compound). CAPACE produces a reduction in peripheral arterial resistance in hypertensive patients with either no change or an increase in cardiac output. The effects of CAPACE and of thiazide diuretics on the renin-angiotensin-aldosterone system are complementary.

INDICATIONS: CAPACE is indicated for the treatment of mild to moderate hypertension in adult patients. It may be used alone or in combination with other antihypertensive agents, especially thiazide-type diuretics. The blood pressure lowering effects of CAPACE and thiazides are additive. CAPACE is indicated for the treatment of patients with congestive heart failure who have not responded adequately to, or cannot be controlled by conventional therapy with diuretics and/or digitalis and in whom vasodilatation is indicated. CAPACE has been used with diuretics and digitalis.

CONTRAINDICATIONS: Hypersensitivity to the product or its components, or other angiotensin-converting enzyme inhibitors. Safety and effectiveness in individuals less than 18 years of age have not been established. Patients with a history of angioneurotic oedema relating to previous treatment with an ACE-inhibitor. (See SPECIAL PRECAUTIONS .)

Should a woman become pregnant while receiving an ACE inhibitor the treatment must be stopped promptly and switched to a different medicine. Should a woman contemplate pregnancy, the doctor should consider alternative medication.

ACE-inhibitors pass through the placenta and can be presumed to cause disturbances in foetal blood pressure regulatory mechanisms. Oligohydramnios as well as hypotension, oliguria and anuria in newborns have been reported after administration of ACE-inhibitors in the second and third trimester. Cases of defective skull ossification have been observed. Prematurity and low birth mass can occur. Angioedema involving the extremities, face, eyes, lips, mucous membranes, tongue, glottis or larynx has been in patients treated with CAPACE. Patients should be advised to immediately report to their physician any signs or symptoms suggesting angioedema (e. g. swelling of face, eyes, lips, tongue, larynx and extremities; difficulty in swallowing or breathing; hoarseness) and to discontinue therapy. If angioedema involves the tongue, glottis or larynx, airway obstruction may occur and be fatal. Emergency therapy including but not necessarily limited to, subcutaneous administration of a 1:1000 solution of adrenaline should be promptly instituted. Swelling confined to the face, mucous membranes of the mouth, lips and extremities has usually resolved with discontinuation of CAPA CE, some cases required medical therapy. (See SIDE-EFFECTS AND SPECIAL PRECAUTIONS). Proteinuria has been seen in patients receiving CAPACE, but this has been predominantly in those who had prior renal disease or in those receiving relatively high doses (in excess of 150 mg per day), or both. Alterations in renal function (as assessed by blood urea and serum creatinine) were infrequent in these patients and did not occur in those who had prior renal disease. Nephritic syndrome (hypoalbuminemia, edema and protein excretion greater than 3 grams per day) has also occurred. In most cases, proteinuria subsided or cleared within 6 months whether or not CAPACE was continued. Membranous glomerulopthy was found in biopsies taken from some proteinuric patients. A causal relationship to CAPACE has not been established. For patients with prior renal disease or those receiving CAPACE at doses greater than 150 mg per day, urinary estimations (dipstick) should be done prior to treatment and monthly during the first 9 months of therapy. If these show increasing amounts of urinary protein, a 24-hour quantitative determination of urinary protein should be done. It this exceeds one gram per day, the benefits and risks of continuing CAPACE should be evaluated. Neutropenia has occurred in some patients receiving CAPACE especially in those who had pre-existing impaired renal function, collagen vascular disease, immunosuppressant therapy, concomitant allopurinol or a combination of these complicating factors. All patients receiving CAPACE should be told to report any signs of infection (e. g. sore throat, fever). Serious infections resulting from the neutropenia and which proved fatal occurred only in patients with impaired renal function. A complete white blood cell count should be done immediately when infection is present. If the infection occurs during the first three months of therapy, CAPACE should be discontinued until the results of the blood count are known. Neutropenia was noted 2½ to 13 weeks after CAPACE had been started. Thus, for patients with impaired renal function, collagen vascular disease, or who are receiving immunosuppressant drugs, white blood cell and differential counts should be performed prior to therapy, every 2 weeks during the first three months of CAPACE therapy and periodically thereafter. If the neutrophil count falls below 1 000/mm 3 CAPACE should be discontinued and the patient’s course should be followed. Bone marrow examinations in patients with neutropenia consistently showed myeloid hypoplasia and decreased numbers of megakaryocytes. Neutropenia was associated with significant alterations of peripheral red blood cell or platelet counts in some patients. Since CAPACE decreases aldosterone production, elevation of serum potassium may occur especially in patients with renal failure, or diabetes mellitus. Potassium sparing diuretics (spironolactone, triamterene and amiloride) or potassium supplements or other drugs associated with increases in serum potassium (e. g. heparin), if needed, should be used with caution since they may lead to a significant increase of serum potassium. Patients already on diuretic therapy may occasionally experience dizziness or light-headedness, indicative of hypotension, that may occur within one hour of the first dose. In patients who are receiving aggressive diuretic therapy, particularly those with either severe renin dependent hypertension (e. g. renovascular hypertension) or severe congestive heart failure, exaggerated hypotensive responses have occurred, again usually within one hour of the initial dose of captopril. The possibility of this occurrence can be lessened in these patients by discontinuing diuretic therapy or significantly reducing the diuretic dose for 4 to 7 days prior to initiating captopril. By commencing captopril therapy with small doses (6,25 or 12,5 mg) the duration of any hypotensive effect is reduced. An exaggerated hypotensive response can be anticipated by medical supervision during the first hour after initial dosing; it can be rapidly reversed by intravenous infusion of normal saline if necessary. A hypotensive episode following the initial dose of CAPACE does not preclude further episodes. In heart failure, where the blood pressure was either normal or low, decreases in mean blood pressure greater than 20 percent were recorded in about half the patients. This transient fall in blood pressure may occur after any of the first several doses and may be associated with arrhythmia or conduction defects. Patients should be followed closely for the first 2 weeks of treatment and whenever the dose of CAPACE or diuretic or both is increased. Some patients with renal disease, particularly those with bilateral renal artery stenosis, have developed increases in blood urea and serum creatinine after reduction of blood pressure with CAPACE, usually along with a diuretic. CAPACE dosage reduction or discontinuation of a diuretic, or both may be required. For some of these patients, it may not be possible to normalise blood pressure and maintain adequate renal perfusion. Some patients with heart failure experienced a reduction in renal function during long term treatment.

DOSAGE AND DIRECTIONS FOR USE: Dosages must be individualised. See WARNINGS regarding hypotension in salt and volume depleted patients. CAPACE should be taken one hour before food intake. Hypertension: The initial dose of CAPACE is 25 mg two or three times a day. If a satisfactory reduction of blood pressure has not been achieved after two weeks the dose of CAPACE may be increased to 50 mg two or three times a day. If after an additional two weeks a further reduction in blood pressure is desirable, a diuretic may be added. For patients already receiving a diuretic, the initial dose of CAPACE should be lower and administered with care. The dose of CAPACE in mild to moderate hypertension must not exceed 150 mg per day. When CAPACE is used alone, concomitant sodium restriction may be beneficial. CAPACE may be used advantageously in conjunction with other antihypertensive agents. Congestive Heart Failure: CAPACE therapy must be started under close medical supervision. It should be added to conventional treatment with diuretic (and digitalis where indicated). A starting dose of 6,25 mg or 12,5 mg three times a day may minimise the duration of any transient hypotensive effect. (See WARNINGS). This dosage may be increased over a period of one to two weeks to 75 - 300 mg per day. Patients with renal impairment: CAPACE excretion is reduced in the presence of impaired renal function. After the desired therapeutic effect has been achieved the total daily dose should be reduced or the dose intervals increased. The following maximum daily doses are suggested as a guide to minimise drug accumulation.

CREATININE CLEARANCE (mL/min/1,75 m 3 )

MINIMUM TOTAL DAILY DOSE (mg)

CAPACE is removed by haemodialysis. When concomitant diuretic therapy is required, a loop diuretic (e. g. furosemide), rather than a thiazide diuretic, is preferred in these patients with impaired renal function.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS: Skin: A rash may occur which is dose related the rash is usually pruritic and maculopapular, but rarely urticarial and generally occurs during the first 4 weeks of treatment. It usually is self-limited and reversible and may respond to antihistamine therapy. Pruritus, flushing, a reversible pemphigoid-like lesion, photosensitivity and angioedema have also been reported. Gastro-Intestinal: A reversible taste impairment has occurred. Loss of mass may be associated with loss of taste. Stomatitis, resembling aphthous ulcers, have been reported. Elevation of liver enzymes has been noted in patients receiving the drug although no causal relationship has been found. Cases of hepatocellular injury with secondary cholestasis have been reported in association with CAPACE administration. Gastric irritation and abdominal pain may occur. Renal: Proteinuria (see WARNINGS). Transient elevations of blood urea and creatinine (See PRECAUTIONS). Increase in the serum potassium concentrations and acidosis. (See WARNINGS). Haematologic: Neutropenia, anemia and thrombocytopenia. (See WARNINGS). Respiratory: Irritating cough. Cardiovascular: Hypotension may occur after initiation of CAPACE therapy in patients with heart failure, renin-dependent hypertension or who are significantly volume depleted. (See WARNINGS). Tachycardia has been observed in volume-depleted patients. Anaphylactoid Reactions: Recent clinical observations have shown an association of hypersensitivity-like (anaphylactoid) reactions during hemodialysis with high-flux dialysis membranes (e. g. AN69) in patients receiving ACE inhibitors as medication. Therefore, special attention should be given to these patients; and in particular, to those having already shown similar reactions. Other: Paraesthesias of the hands, serum sickness, bronchospasm and lymphadenopathy have been reported. Angioedema of the face, eyes, lips, mucous membranes, tongue, glottis or larynx and the extremities may occur. CAPACE should be used only with extreme caution in patients with aortic stenosis because of the potentially harmful consequences of reduced coronary perfusion secondary to the reduced blood pressure. CAPACE may cause a false-positive urine test for acetone. Nursing mothers: Concentrations of unchanged captopril appear in human breast milk. Caution should be exercised when CAPACE is administered for a nursing woman. Surgery/Anaesthesia: In patients undergoing major surgery or during anaesthesia with agents that produce hypotension, CAPACE will block angiotensin II formation secondary to compensatory renin release. This may lead to hypotension which can be corrected by volume expansion. Agents Having Vasodilator Activity: Data on the effect of concomitant use of other vasodilators in patients receiving CAPACE for heart failure are not available; therefore, nitroglycerin or other nitrates (as used for management of angina) or other drugs having vasodilator activity should, if possible, be discontinued before starting CAPACE. If resumed during CAPACE therapy, such agents should be administered cautiously, and perhaps at low dosage. Agents Affecting Sympathetic Activity: The sympathetic nervous system may be especially important in supporting blood pressure in patients receiving captopril alone or with diuretics. Therefore, agents affecting sympathetic activity (e. g. ganglionic blocking agents or adrenergic neuron blocking agents) should be used with caution. Inhibitors of endogenous prostaglandin synthesis: It has been reported that indomethacin may reduce the antihypertensive effect of CAPACE, especially in cases of low renin hypertension. Other nonsteroidal anti-inflammatory agents (e. g. aspirin) may also have this effect. Lithium: Increased serum lithium levels and symptoms of lithium nephrotoxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. These drugs should be coadministered with caution and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, it may increase the risk of lithium toxicity.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT: In the event of overdosage, hypotension would be the most important problem. Volume expansion with an intravenous infusion of normal saline is the treatment of choice. Captopril is removed by haemodialysis. Treatment is symptomatic and supportive.

IDENTIFICATION: CAPACE 25 mg: A slightly mottled, white 6,5 mm square tablet, biconvex, quadrisected on one face.

PRESENTATION: CAPACE 25 mg is available in blister packs of 60 tablets.

STORAGE INSTRUCTIONS: Store at room temperature not exceeding 25°C. Protect from excessive moisture, heat and light. KEEP OUT OF REACH OF CHILDREN.

REGISTRATION NUMBER: CAPACE 25 mg - 27/7.1/0398

NAME AND BUSINESS ADDRESS OF APPLICANT: GAREC (Pty) Ltd PO Box 1123 Halfway House 1685

DATE OF PUBLICATION OF THIS PACKAGE INSERT: 18 January 1993

Current: May 2004 Source: Community Pharmacy SAEPI HOME PAGE TRADE NAME INDEX GENERIC NAME INDEX FEEDBACK Information presented by Malahyde Information Systems © Copyright 1996-2005

Nexadron, Nexadron

Skincare - Nexadron (Brand name: decadron)

Decadron is used to treat conditions such as arthritis, blood/hormone/immune system disorders, allergic reactions, certain skin and eye conditions, breathing problems, certain bowel disorders. Also it is used in the treatment of cancers of the white blood cells (leukemias), and lymph gland cancers (lymphomas).

Active Ingredient: Dexamethasone

Availability: In Stock (34 Packages)

Product Description Common use Decadron is used to treat conditions such as arthritis, blood/hormone/immune system disorders, allergic reactions, certain skin and eye conditions, breathing problems, certain bowel disorders. Also it is used in the treatment of cancers of the white blood cells (leukemias), and lymph gland cancers (lymphomas). Finally, Decadron is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of corticosteroids.

Dosage and direction Take this medication by mouth as directed by your doctor. The initial oral dose is 0.75 to 9 mg daily depending on the disease. The initial dose should be adjusted according to the response to therapy. Take with food or milk to prevent stomach upset. Take this medication by mouth with food or a full glass of water or milk unless your doctor directs you otherwise. If you take this medication once daily, take it in the morning before 9 AM. Use this medication regularly in order to get the most benefit from it. Take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Follow the dosing schedule carefully, and take this medication exactly as prescribed. Do not stop taking this medication without consulting your doctor. Inform your doctor if your condition does not improve or worsens.

Precautions Do not get immunizations, vaccinations, or skin tests unless specifically directed by your doctor. Before taking Decadron, tell your doctor or pharmacist if you have any allergies, your medical history: active fungal infections, kidney or liver disease, mental/mood conditions, low blood minerals, thyroid disease, stomach/intestinal problems, high blood pressure, heart problems, diabetes, eye diseases, brittle bones, history of blood clots. If you have been taking this medication for a long time, your body may not make enough natural hormones while you are under physical stress. Your dose may need to be adjusted. If you have stopped taking this drug within the past 12 months, you may need to start taking it again if your body is under physical stress. Before having surgery, tell your doctor or dentist that you are using this medication or have taken it within the last 12 months. If you have a history of ulcers or take large doses of aspirin or other arthritis medication. Limit alcoholic beverages while taking this medication to decrease the risk of stomach/intestinal bleeding. If you have diabetes, this drug may make it harder to control your blood sugar levels. Monitor your blood sugar levels regularly and inform your doctor of the results. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. This drug may pass into breast milk and could have undesirable effects on a nursing infant. Therefore, breast-feeding is not recommended while using this medication. Avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose, chickenpox or measles unless you have previously had these diseases (in childhood). If you are exposed to one of these infections and you have not previously had it, seek immediate medical attention.

Contraindications Do NOT use Decadron if you are allergic to any ingredient in Decadron, you have a systemic fungal infection, you are taking mifepristone. Contact your doctor or health care provider immediately if any of these apply to you.

Possible side effects

Side effects of Decadron depend on the dose, the duration and the frequency of administration. Short courses of dexamethasone usually are well tolerated with few and mild side effects. Long term, high dose dexamethasone usually will produce predictable and potentially serious side effects. Whenever possible, the lowest effective dose of dexamethasone should be used for the shortest possible length of time to minimize side effects. Alternate day dosing also can help reduce side effects. Side effects include fluid retention, weight gain, high blood pressure, loss of potassium, headache, muscle weakness, puffiness, and hair growth on the face, thinning and easy bruising of skin, glaucoma, cataracts, peptic ulceration, worsening of diabetes, irregular menses, growth retardation in children, convulsions, stomach upset, headache, dizziness, menstrual changes, trouble sleeping, increased appetite, or weight gain may occur, depression, euphoria, insomnia, mood swings, personality changes, and even psychotic behavior. A very serious allergic reaction to this drug is rare. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Drug interactions Drugs such as phenobarbital, ephedrine, phenytoin (Dilantin), and rifampin (Rifadin, Rimactane) may increase the breakdown of corticosteroids by the liver. As a result it may be lower blood levels and reduced effects. Therefore, the dose of corticosteroid may need to be increased if treatment with any of these agents is begun.

Missed dose If you are taking this medication daily and on a regular schedule, and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Overdose Seek emergency medical attention if you think you have used too much of this medicine.

Storage Decadron should be stored at 68-77 F (20-25 C) and not frozen

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Product Description Common use Decadron is used to treat conditions such as arthritis, blood/hormone/immune system disorders, allergic reactions, certain skin and eye conditions, breathing problems, certain bowel disorders. Also it is used in the treatment of cancers of the white blood cells (leukemias), and lymph gland cancers (lymphomas). Finally, Decadron is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of corticosteroids.

Dosage and direction Take this medication by mouth as directed by your doctor. The initial oral dose is 0.75 to 9 mg daily depending on the disease. The initial dose should be adjusted according to the response to therapy. Take with food or milk to prevent stomach upset. Take this medication by mouth with food or a full glass of water or milk unless your doctor directs you otherwise. If you take this medication once daily, take it in the morning before 9 AM. Use this medication regularly in order to get the most benefit from it. Take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Follow the dosing schedule carefully, and take this medication exactly as prescribed. Do not stop taking this medication without consulting your doctor. Inform your doctor if your condition does not improve or worsens.

Precautions Do not get immunizations, vaccinations, or skin tests unless specifically directed by your doctor. Before taking Decadron, tell your doctor or pharmacist if you have any allergies, your medical history: active fungal infections, kidney or liver disease, mental/mood conditions, low blood minerals, thyroid disease, stomach/intestinal problems, high blood pressure, heart problems, diabetes, eye diseases, brittle bones, history of blood clots. If you have been taking this medication for a long time, your body may not make enough natural hormones while you are under physical stress. Your dose may need to be adjusted. If you have stopped taking this drug within the past 12 months, you may need to start taking it again if your body is under physical stress. Before having surgery, tell your doctor or dentist that you are using this medication or have taken it within the last 12 months. If you have a history of ulcers or take large doses of aspirin or other arthritis medication. Limit alcoholic beverages while taking this medication to decrease the risk of stomach/intestinal bleeding. If you have diabetes, this drug may make it harder to control your blood sugar levels. Monitor your blood sugar levels regularly and inform your doctor of the results. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. This drug may pass into breast milk and could have undesirable effects on a nursing infant. Therefore, breast-feeding is not recommended while using this medication. Avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose, chickenpox or measles unless you have previously had these diseases (in childhood). If you are exposed to one of these infections and you have not previously had it, seek immediate medical attention.

Contraindications Do NOT use Decadron if you are allergic to any ingredient in Decadron, you have a systemic fungal infection, you are taking mifepristone. Contact your doctor or health care provider immediately if any of these apply to you.

Possible side effects

Side effects of Decadron depend on the dose, the duration and the frequency of administration. Short courses of dexamethasone usually are well tolerated with few and mild side effects. Long term, high dose dexamethasone usually will produce predictable and potentially serious side effects. Whenever possible, the lowest effective dose of dexamethasone should be used for the shortest possible length of time to minimize side effects. Alternate day dosing also can help reduce side effects. Side effects include fluid retention, weight gain, high blood pressure, loss of potassium, headache, muscle weakness, puffiness, and hair growth on the face, thinning and easy bruising of skin, glaucoma, cataracts, peptic ulceration, worsening of diabetes, irregular menses, growth retardation in children, convulsions, stomach upset, headache, dizziness, menstrual changes, trouble sleeping, increased appetite, or weight gain may occur, depression, euphoria, insomnia, mood swings, personality changes, and even psychotic behavior. A very serious allergic reaction to this drug is rare. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Drug interactions Drugs such as phenobarbital, ephedrine, phenytoin (Dilantin), and rifampin (Rifadin, Rimactane) may increase the breakdown of corticosteroids by the liver. As a result it may be lower blood levels and reduced effects. Therefore, the dose of corticosteroid may need to be increased if treatment with any of these agents is begun.

Missed dose If you are taking this medication daily and on a regular schedule, and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Overdose Seek emergency medical attention if you think you have used too much of this medicine.

Storage Decadron should be stored at 68-77 F (20-25 C) and not frozen

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Primadex Forte Tablet - Situs Nama Obat, Primadex

Primadex Forte Tablet . Informasi obat kali ini akan menjelaskan jenis obat Infeksi saluran kemih, saluran pencernaan Kotrimoksazol. yang diantaranya menjelaskan dosis obat, komposisi atau kandungan obat, manfaat atau kegunaan dan khasiat atau dalam bahasa medis indikasi, aturan pakai Primadex Forte Tablet, cara minum/makan atau cara menggunakannya, juga akan menerangkan efek samping atau kerugian, pantangan atau kontra indikasi serta bahayanya, over dosis atau keracunan, dan farmakologi serta meknisme kerja dan harga dari obat Primadex Forte Tablet, dan inilah penjelasannya:

PRIMADEX FORTE TABLET GOLONGAN K Merah

KANDUNGAN Per tablet. Kotrimoksazol. Trimetoprim 160 mg, Sulfametoks

INDIKASI Infeksi saluran kemih, saluran pencernaan, & saluran napas yang disebabkan oleh bakteri Gram positif & Gram negatif yang sensitif terhadap Kotrimoksazol.

KONTRA INDIKASI Anemia megaloblastik. Hamil & menyusui. Bayi berusia kurang dari 2 bulan.

PERHATIAN Kerusakan hati & ginjal, reaksi alergi atau asma bronkhial.

EFEK SAMPING Anemia megaloblastik, leukopenia, trombositopenia, reaksi kulit, gangguan saluran pencernaan, sakit kepala, depresi, reaksi hematologis.

INDEKS KEAMANAN PADA WANITA HAMIL Penelitian pada hewan menunjukkan efek samping pada janin ( teratogenik atau embriosidal atau lainnya) dan belum ada penelitian yang terkendali pada wanita atau penelitian pada wanita dan hewan belum tersedia. Obat seharusnya diberikan bila hanya keuntungan potensial memberikan alasan terhadap bahaya potensial pada janin.

KEMASAN Tablet forte 100 biji.

DOSIS 2 kali sehari 1 tablet.

PENYAJIAN Dikonsumsi bersamaan dengan makanan

HARGA Harga M. Rp. 49.644/kemasan

PABRIK Dexa Medica.

Chicago Aveda Hair Salon, Xex

a love of life

your favorite products

Barbershop at XEX

In the Community

XEX is Chicago’s premier hair salon. We offer a variety of hair and make up services and are conveniently located in the Chicago Loop. Visit our services page to learn more about are extensive list of services.

We are also devoted to our community and are pleased to donate a portion of the profits from the services you receive to Feeding America. Visit our community page to learn more about our ongoing community efforts, both in Chicago and abroad.

XEX is the exclusive gallery in North America to represent renowned Venetian Murano glass artist Darra. We have an assortment of one of a kind pieces in various functional art interpretations. We invite you to learn more about Darra .

We look forward to sharing your company.

From our Blog

Prince Dado Ruspoli, Ryspolit

Prince Dado Ruspoli

Prince Dado Ruspoli, who has died in Rome aged 80, was one of the leading figures of Italy's "Dolce Vita" - the circle of beautiful people immortalised by Federico Fellini in his film about high society in 1950s Rome - and a byword for aristocratic dissipation, extravagance and charm.

In his handsome prime, the Maserati-driving prince was the toast of his haunts on the Via Veneto, at St Tropez and on Capri. Men, particularly actors, imitated his careless dress sense – going barefoot in summer when it was a novelty. The most celebrated anecdote about him was that he used to promenade with a parrot on his shoulder. Although he always insisted it was merely a wounded raven he had found on the tennis court, the image inspired the comic Toto's screen portrayal of The Emperor of Capri (1949).

Ruspoli's friends were all the right people; he shared a villa with Roger Vadim and Jane Fonda, while Brigitte Bardot came to the baptism of his son. He knew Truman Capote, Willem de Kooning and Balthus, and took lessons in hypnotism from Orson Welles. Ruspoli developed a life-long interest in magic and the occult after witnessing a demonstration of Welles's powers.

While sitting in a cafe, Welles asked him what he would like to see happen. Ruspoli told him that nothing would please him more than that a pretty girl at a neighbouring table drop her Bloody Mary down the front of her shirt. The glass duly obliged.

This taste for the exotic naturally led Ruspoli in the 1960s to Asia, where he became a student of yoga and transcendentalism. His travels in the region also coincided with his taste for opium, and the first of several scandals concerning him came in 1953 when he was caught with 5lb of the drug hidden in his car.

He had first become hooked at 17, but had been rescued by Jean Cocteau. The respite, however, was only temporary. His other weakness was for women. Ruspoli, claimed his sometime fellow orgiast, Salvador Dali, had "the biggest limousine in Europe". His first two marriages were ruptured by his unabashed infidelity. The first, in 1947, to another aristocrat, Francesca Blanc, ended after six years. A decade later she took her own life. The second, in 1964, to a French painter, Nancy de Girard de Charbonnieres, also failed, though it produced an heir. He was not brought to heel until his seventies, when he married a French model 40 years his junior.

He fathered his second child by her at the age of 73, and by then was content in the role of family man. Nonetheless, he was proud of his continued vitality. "I am a tree still full of fruit," he liked to say, "when all around me I see so many withered vines."

Alessandro (Dado) Maria Galeazzo Ruspoli, 9th Prince of Cerveteri, 9th Marquis of Riano and 14th Count of Vignanello, was born in the family palazzo by the Via del Corso, Rome, on December 9 1924. His father wrote poetry, while his Neapolitan mother was the heiress to the largest industrial fortune in Latin America. His younger brother was a somewhat eccentric figure on the fringes of politics.

The Ruspolis originally hailed from Siena, but moved to Rome in the mid-15th century, acquiring the palazzo some 300 years later. Its treasures include a 120-step staircase made from antique marble. The family's other possessions included Vignanello, a castle 40 miles north of the capital built by Benedictines in the 9th century. It has one of the finest Renaissance gardens in Italy, and its maintenance was long Dado Ruspoli's concern. For, despite his wayward tendencies, he was not simply a wastrel, enjoying as he did writing poetry and cultivating an informed interest in the arts.

He funded ballet and musical companies, and gave to charitable causes with a generosity that was, as in all things, almost boundless. Perhaps too boundless, for by the time he reached pensionable age he began to feel the pinch. In 1990, the Palazzo Ruspoli was sold to a financier and is now a museum.

"Haven't you ever worked?" he was once asked. "No," came the riposte, "I've never had time." Now, however, he began to accept parts in European art films, and landed a minor role in The Godfather: Part III (1990). He could have made a fortune from his contacts when younger, but he took more pleasure in enhancing the lives of others, and was at his happiest when in good company.

Dado Ruspoli died in Rome on January 11. His funeral was held in the family church, San Lorenzo in Lucina. He is survived by his wife Patricia, and by the son of his second marriage and the son and daughter of the third. He also had two sons with an actress, Debra Berger.

He was a firm believer in reincarnation.

Mithra In The World - Mithra Pharmaceuticals, Gestodelle

Mithra aims to emulate its successful commercial model internationally in France, Germany and Brazil, as the size of the Women’s Health market in these countries is significant. According to Datamonitor, Brazil is the second largest market for contraception behind the United States and Germany and France are among the biggest markets in Europe. Over the last two years, the Company has established local representation offices in these countries, led by seasoned local women’s healthcare professionals. By being present as a local pharmaceutical company and based on its strong image with large pharmaceutical companies and its focus on the women’s healthcare market, Mithra Pharmaceuticals believes it is well positioned to in-license drug portfolios or to make targeted acquisitions to start building a commercial franchise in these countries.

Once a commercial activity is established in these countries, Mithra Pharmaceuticals will pursue a strategy of further developing these activities by seeking to obtain marketing authorisation for its own pharmaceutical dossiers, possibly followed by the commercialisation of its own innovative products and complex generics.

Mithra Pharmaceuticals

Rue Saint-Georges 5 4000 Liege Belgium

Tel. +32 (0)4 349 28 22 Fax. +32 (0)4 349 28 21 Email. info@mithra. com

Awards

Ltv® 1000 Ventilator, Portable Hospital Ventilator, Pulmovent

LTV ® 1000 ventilator

Use a portable ventilation system approved for transport and military use

Much smaller than comparably equipped ventilators, the LTV ® 1000 ventilator is a conveniently portable advanced ventilation system for patients weighing at least 5 kg. This hospital ventilator is diagnostic-ready with Auto-PEEP and static compliance features and capable of utilizing the LTM™ II Graphics Monitor for full-color, user-selectable ventilator waveform displays and diagnostics.

The ventilator innovatively provides variable rise time, sensitivity flow trigger, flow termination, variable time termination and leak compensation.

Enhanced patient care

O 2 Flush, O 2 Cylinder Duration and Automatic O 2 Switchover features on the hospital ventilator enhance patient care.

The ventilator features an internal oxygen blending system, connected to a high or low pressure O 2 source, including pressure control, pressure support, volume control, adjustable flow triggering and invasive or noninvasive ventilation with apnea backup mode.

Ciproheptadina Medlineplus Medicinas, Complamin

Ciproheptadina

Plan de la FDA para retirar del mercado algunos medicamentos no aprobados para la tos, el resfriado y la alergia

Esta alerta de seguridad no se aplica a este medicamento, sino solo a algunos productos que contienen esta droga. Ademas, es importante que usted sepa que no existen problemas con la mayoria de los productos descriptos en esta monografia. Asimismo, algunas companias farmaceuticas pueden decidir solicitar la aprobacion completa de la FDA para poder seguir vendiendo sus productos.

El 2 de marzo de 2011, la Administracion de Drogas y Alimentos (FDA, por sus siglas en ingles) emitio una alerta de seguridad acerca de algunos medicamentos de receta para la tos, el resfriado y las alergias que no estan aprobados y contienen este medicamento en combinacion con otros farmacos. La seguridad, eficacia y calidad de estos productos no esta aprobada por la FDA. La FDA pidio a las companias farmaceuticas dejar de enviar la mayoria de estos productos a la venta en los EE. UU. en los proximos 6 meses. Aunque algunos de estos productos se venden desde hace muchos anos, las leyes acerca de lo que una empresa debe demostrar a la FDA para la aprobacion de un medicamento son mas duras y la aplicacion de estas leyes se esta llevando a cabo hoy en dia. La FDA tomo esta accion debido a las preocupaciones acerca de ciertos riesgos potenciales asociados con el uso de estos medicamentos. Estos riesgos pueden incluir:

la posibilidad del uso indebido en bebes y ninos pequenos

posibles riesgos en la combinacion de ingredientes

problemas con la liberacion prolongada que puede incrementar el riesgo en pacientes al recibir demasiada o muy poca medicacion

Si le preocupa que el medicamento que usted esta tomando para la tos, el resfriado o la alergia no este aprobado por la FDA, usted debe hablar con su medico o farmaceutico. Si la medicacion que esta tomando no esta aprobada, su medico puede recetarle otro medicamento o puede recomendarle un medicamento de venta sin receta para la tos, el resfriado o la alergia. Hay muchos productos alternativos aprobados seguros y efectivos que se pueden tomar en su lugar. Probablemente su medico le receto el medicamento sin saber que la FDA no lo habia aprobado. Esto se debe a que ha sido muy dificil para los medicos y farmaceuticos saber si estos productos estan aprobados o no por la FDA. Para informacion adicional:

Usted puede visitar el sitio web de la FDA (en ingles) para obtener mas informacion sobre este retiro del mercado de medicamentos no aprobados para la tos, el resfriado y la alergia (http://www. fda. gov/ForConsumers/ConsumerUpdates/ucm244852.htm ).

Puede encontrar una lista de productos no aprobados aqui (en ingles) (http://www. fda. gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm245279.htm .

Para informacion sobre como desechar de los medicamentos no utilizados, vaya a http://www. fda. gov/ForConsumers/ConsumerUpdates/ucm162971.htm .

?Para cuales condiciones o enfermedades se prescribe este medicamento?

La ciproheptadina alivia el enrojecimiento, la irritacion, la picazon y el lagrimeo de los ojos; los estornudos; y la secrecion nasal ocasionados por las alergias, las sustancias irritantes presentes en el aire y la fiebre del heno. Tambien puede usarse para aliviar la comezon de las afecciones alergicas de la piel, y para tratar la urticaria, incluso la urticaria ocasionada por exposicion al frio y por frotarse la piel. La ciproheptadina tambien se usa a veces para tratar las reacciones alergicas en personas que recibieron derivados sanguineos como parte de un tratamiento medico, y para tratar reacciones alergicas que pudieran ser mortales, una vez que los sintomas estan en control mediante el uso de otros medicamentos. La ciproheptadina ayudara a aliviar los sintomas, pero no tratara la causa de los mismos ni acelerara la recuperacion. La ciproheptadina pertenece a una clase de medicamentos llamados antihistaminicos. Actua al bloquear la accion de la histamina, una sustancia del cuerpo que provoca los sintomas de alergia.

?Como se debe usar este medicamento?

La ciproheptadina se presenta en forma de tabletas y de una solucion (liquido) para administrarse por via oral. Suele tomarse dos o tres veces al dia. Tome la ciproheptadina aproximadamente a la(s) misma(s) hora(s) todos los dias. Siga atentamente las instrucciones de la etiqueta de la receta y pidales a su medico o a su farmaceutico que le expliquen cualquier cosa que no entienda. Tome la ciproheptadina segun lo indicado. No aumente ni disminuya la dosis, ni la tome con mas frecuencia que la indicada por su medico.

Si esta tomando la solucion, no use una cuchara de cocina para medir la dosis. Use la cuchara o la taza medidora que viene con el medicamento, o use una cuchara disenada especialmente para medir medicamentos.

?Que otro uso se le da a este medicamento?

La ciproheptadina tambien se usa para el tratamiento del sindrome de Cushing (una condicion anormal que se debe a un exceso de hormonas [corticosteroides]) y para tratar ciertos tipos de dolor de cabeza, como la migrana. Consulte a su medico sobre los posibles riesgos de usar este medicamento en su caso.

A veces se receta este medicamento para otros usos. Pidale mas informacion a su medico o a su farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes de tomar ciproheptadina,

digales a su medico y a su farmaceutico si es alergico a la ciproheptadina, a otros antihistaminicos o a otros medicamentos.

digales a su medico y a su farmaceutico que medicamentos con y sin receta, vitaminas, suplementos nutricionales y productos medicinales a base de hierbas esta tomando o piensa tomar. No olvide mencionar ninguno de los siguientes: otros medicamentos contra las alergias o el resfriado; medicamentos para la ansiedad, la depresion o las convulsiones; relajantes musculares; analgesicos opiaceos; sedantes; pildoras para dormir y tranquilizantes. Es posible que su medico deba cambiar la dosis de sus medicamentos o vigilarle estrechamente por si presentara efectos secundarios.

digale a su medico si tiene o ha tenido asma, glaucoma (una enfermedad en la que el aumento de la presion del ojo puede causar perdida gradual de la vision), ulceras, dificultad para orinar (debido al agrandamiento de la prostata), enfermedad cardiaca, presion arterial alta, convulsiones, o una glandula tiroides demasiado activa.

digale a su medico si esta embarazada, planea quedar embarazada o si esta lactando. Si queda embarazada mientras esta tomando ciproheptadina, llame a su medico.

hable con su medico sobre los riesgos y beneficios de tomar esta medicina si usted tiene 65 anos de edad o mas. Los adultos mayores no suelen tener ciproheptadina porque no es tan seguro y efectivo que otro medicamentos que pueden usarse para tratar la misma condicion.

si le van a hacer una cirugia, incluyendo una cirugia dental, digales al medico o al dentista que esta tomando ciproheptadina.

tenga en cuenta que este medicamento puede causarle somnolencia. Evite conducir vehiculos u operar maquinarias hasta que sepa como le afecta este medicamento.

preguntele a su medico si es prudente beber alcohol mientras este tomando este medicamento. El alcohol puede empeorar los efectos secundarios de la ciproheptadina.

?Que dieta especial debo seguir mientras tomo este medicamento?

Thu?c Glucofine 500mg, Glucofine

Glucofine 500mg

THÀNH PH?N: M?i viên nén bao phim ch?a:

- Metformin hydrochlorid (tuong duong Metformin base 390 mg). 500 mg. - Tá du?c v?a d? 1 viên nén bao phim.

CH? D?NH: - Di?u tr? b?nh dái tháo du?ng không ph? thu?c insulin (typ II): Don tr? li?u, khi không th? di?u tr? tang glucose huy?t b?ng ch? d? an don thu?n. - Có th? dùng metformin d?ng th?i v?i m?t sulfonylurê khi ch? d? an và khi dùng metformin ho?c sulfonylurê don thu?n không có hi?u qu? ki?m soát glucose huy?t m?t cách d?y d?.

CH?NG CH? D?NH: - Quá m?n v?i metformin và các thành ph?n khác. - Ngu?i b?nh có tr?ng thái d? hóa c?p tính, nhi?m khu?n, ch?n thuong (ph?i du?c di?u tr? dái tháo du?ng b?ng insulin). - Gi?m ch?c nang th?n do b?nh th?n, ho?c r?i lo?n ch?c nang th?n (creatinin huy?t thanh ³1,5 mg/decilít ? nam gi?i, ho?c ³1,4 mg/decilít ? ph? n?), ho?c có th? do nh?ng tình tr?ng b?nh lý nhu tr?y tim m?ch, nh?i máu co tim c?p tính và nhi?m khu?n huy?t gây nên. - Nhi?m acid chuy?n hóa c?p tính và m?n tính, có ho?c không có hôn mê (k? c? nhi?m acid – ceton do dái tháo du?ng). - Suy gi?m ch?c nang gan, b?nh gan n?ng, b?nh tim m?ch n?ng, b?nh hô h?p n?ng v?i gi?m oxygen huy?t. - Suy tim sung huy?t, tr?y tim m?ch, nh?i máu co tim c?p tính. - B?nh ph?i thi?u oxygen m?n tính.

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