Dazamide, Dazamide

Dazamide

Dazamide - General Information

One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Pharmacology of Dazamide

Dazamide is a potent carbonic anhydrase inhibitor, effective in the control of fluid secretion, in the treatment of certain convulsive disorders and in the promotion of diuresis in instances of abnormal fluid retention. Dazamide is not a mercurial diuretic. Rather, it is a nonbacteriostatic sulfonamide possessing a chemical structure and pharmacological activity distinctly different from the bacteriostatic sulfonamides.

Dazamide for patients

Adverse reactions common to all sulfonamide derivatives may occur: anaphylaxis, fever, rash (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), crystalluria, renal calculus, bone marrow depression, thrombocytopenic purpura, hemolytic anemia, leukopenia. pancytopenia, and agranulocytosis. Caution is advised for early detection of such reactions and the drug should be discontinued and appropriate therapy instituted.

In patients with pulmonary obstruction or emphysema where alveolar ventilation may be impaired, DIAMOX, which may precipitate or aggravate acidosis, should be used with caution.

Gradual ascent is desirable to try to avoid acute mountain sickness. If rapid ascent is undertaken and DIAMOX is used, it should be noted that such use does not obviate the need for prompt descent if severe forms of high altitude sickness occur, ie, high altitude pulmonary edema (HAPE) or high altitude cerebral edema.

Caution is advised for patients receiving concomitant high-dose aspirin and DIAMOX, as anorexia, tachypnea, lethargy, metabolic acidosis, coma, and death have been reported.

Both increases and decreases in blood glucose levels have been described in patients treated with acetazolamide. This should be taken into consideration in patients with impaired glucose tolerance or diabetes mellitus.

Acetazolamide treatment may cause electrolyte imbalances, including hyponatremia and hypokalemia, as well as metabolic acidosis. Therefore, periodic monitoring of serum electrolytes is recommended. Particular caution is recommended in patients with conditions that are associated with, or predispose a patient to, electrolyte and acid/base imbalances, such as patients with impaired renal function (including elderly patients), patients with diabetes mellitus, and patients with impaired alveolar ventilation.

Some adverse reactions to acetazolamide, such as drowsiness, fatigue, and myopia, may impair the ability to drive and operate machinery.

Dazamide Interactions

DIAMOX®. modifies phenytoin metabolism with increased serum levels of phenytoin. This may increase or enhance the occurrence of osteomalacia in some patients receiving chronic phenytoin therapy. Caution is advised in patients receiving chronic concomitant therapy.

By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect. Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving primidone.

Because of possible additive effects with other carbonic anhydrase inhibitors, concomitant use is not advisable.

Acetazolamide may increase the effects of other folic acid antagonists.

Acetazolamide may increase or decrease blood glucose levels. Consideration should be taken in patients being treated with antidiabetic agents.

Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect.

Acetazolamide reduces urinary excretion of quinidine and may enhance its effect.

Acetazolamide may prevent the urinary antiseptic effect of methenamine.

Acetazolamide increases lithium excretion and the lithium may be decreased.

Acetazolamide and sodium bicarbonate used concurrently increases the risk of renal calculus formation.

Acetazolamide may elevate cyclosporine levels.

Dazamide Contraindications

Hypersensitivity to acetazolamide or any excipients in the formulation. Since acetazolamide is a sulfonamide derivative, cross sensitivity between acetazolamide, sulfonamides and other sulfonamide derivatives is possible.

DIAMOX therapy is contraindicated in situations in which sodium and/or potassium blood serum levels are depressed, in cases of marked kidney and liver disease or dysfunction, in suprarenal gland failure, and in hyperchloremic acidosis. It is contraindicated in patients with cirrhosis because of the risk of development of hepatic encephalopathy .

Long-term administration of DIAMOX is contraindicated in patients with chronic noncongestive angle-closure glaucoma since it may permit organic closure of the angle to occur while the worsening glaucoma is masked by lowered intraocular pressure.

Additional information about Dazamide

Dazamide Indication: For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma Mechanism Of Action: The anticonvulsant activity of Dazamide may depend on a direct inhibition of carbonic anhydrase in the CNS. which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water. Drug Interactions: Aspirin The salicylate at high dose increases the effect of the carbonic anhydrase inhibitors Salicyclic acid The salicylate at high dose increases the effect of the carbonic anhydrase inhibitors Cyclosporine Dazamide increases the effect of toxicity of cyclosporine Memantine Possible increased levels of memantine Bismuth Subsalicylate The salicylate at high dose increases the effect of the carbonic anhydrase inhibitors Food Interactions: Take with food; at least 6 hours before bedtime. Drink plenty of liquids. Generic Name: Acetazolamide Synonyms: Acetamidothiadiazolesulfonamide; Acetazolamid; Acetazolamide Sodium; Acetazolamine; Acetazoleamide; Acetozalamide; Carbonic Anhydrase Inhibitor 6063 Drug Category: Diuretics; Anticonvulsants; Carbonic Anhydrase Inhibitors Drug Type: Small Molecule; Approved Other Brand Names containing Acetazolamide: Acetamox; Acetazolam; Ak-Zol; Apo-Acetazolamide; Atenezol; Cidamex; Dazamide; Defiltran; Dehydratin; Diacarb; Diakarb; Diamox; Diamox Sequels; Didoc; Diluran; Diuramid; Diureticum-Holzinger; Diuriwas; Diutazol; Donmox; Duiramid; Edemox; Eumicton; Fonurit; Glaupax; Glupax; Natrionex; Nephramid; Nephramide; Phonurit; Sk-Acetazolamide; Storzolamide; Vetamox; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: 98% Biotransformation: Not Available Half Life: 3 to 9 hours Dosage Forms of Dazamide: Tablet Oral Chemical IUPAC Name: N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide Chemical Formula: C4H6N4O3S2 Acetazolamide on Wikipedia: http://en. wikipedia. org/wiki/Acetazolamide Organisms Affected: Humans and other mammals

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Flooring Lafayette La, Dronet

Flooring in Lafayette, LA

Shop our reputable store to find the latest flooring styles at the lowest prices. Replace the outdated and damaged floors in your home with the help of the experts at Hollier’s Flooring America. Our team is proud to provide you with affordable flooring, as well as the floor installation services you need to ensure the longevity of your new floors.

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Our contractors boast decades of experience and are equipped with the skills necessary to deliver a flawless installation in any room in your home. We remove your existing floors and replace them with the flooring material of your dreams, producing a successful and dependable new floor with every residential project. Plus, we offer exclusive guarantees and warranties on our affordable flooring services to ensure your maximum satisfaction. Ask about our tile flooring installation and carpet installation offers.

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Neo-Lotan Plus, Hydrochlorothiazide, Losartan, Neo Lotan Plus

Neo-lotan Plus

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Losartan is used to treat high blood pressure (hypertension). High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Losartan works by blocking the action of a substance in the body that causes blood vessels to tighten. As a result, losartan relaxes blood vessels. This lowers blood pressure. Losartan is also used to decrease the risk of stroke in patients with high blood pressure and a condition called left ventricular hypertrophy (LVH). LVH is an enlargement of the left pumping chamber of the heart and can cause problems with the way the heart pumps blood. Losartan is also used to treat a condition called diabetic nephropathy. Diabetic nephropathy is a complication of type 2 diabetes which causes the kidneys to not work properly.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For losartan, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to losartan or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Rare Hoarseness swelling of face, mouth, hands, or feet trouble in swallowing or breathing (sudden) Incidence not known Abdominal pain black, tarry stools bleeding gums blood in urine or stools coma confusion convulsions decreased urine output difficult breathing fast or irregular breathing headache increased thirst irregular heartbeat large, flat, bluish patches on the skin muscle pain or cramps nausea or vomiting painful knees and ankles pinpoint red spots on skin unusual bleeding or bruising unusual tiredness or weakness upper right abdominal pain weakness or heaviness of legs yellow eyes and skin Check with your doctor as soon as possible if any of the following side effects occur: Less common Cough, fever or sore throat dizziness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Headache Less common Back pain diarrhea fatigue nasal congestion Rare Cough, dry leg pain muscle cramps or pain sinus problems trouble in sleeping Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Using losartan with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Lithium Using losartan with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aceclofenac Acemetacin Alclofenac Apazone Benoxaprofen Bromfenac Bufexamac Carprofen Celecoxib Clometacin Clonixin Dexketoprofen Diclofenac Diflunisal Dipyrone Droxicam Etodolac Etofenamate Felbinac Fenbufen Fenoprofen Fentiazac Floctafenine Fluconazole Flufenamic Acid Flurbiprofen Ibuprofen Indomethacin Indoprofen Isoxicam Ketoprofen Ketorolac Lornoxicam Meclofenamate Mefenamic Acid Meloxicam Nabumetone Naproxen Niflumic Acid Nimesulide Oxaprozin Oxyphenbutazone Phenylbutazone Pirazolac Piroxicam Pirprofen Propyphenazone Proquazone Rifampin Rofecoxib Sulindac Suprofen Tenidap Tenoxicam Tiaprofenic Acid Tolmetin Valdecoxib Zomepirac

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For losartan, the following should be considered: Pediatric Studies on losartan have been done only in adult patients, and there is no specific information comparing use of losartan in children younger than 6 years of age with use in other age groups. Geriatric losartan has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults. Pregnancy Pregnancy Category D: Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Check with your doctor immediately if you think that you may be pregnant. Losartan may cause birth defects or other problems in the baby if taken during pregnancy. It is important that your doctor check your progress at regular visits to make sure that losartan is working properly and to check for unwanted effects. Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure. Dizziness or lightheadedness may occur after the first dose of losartan, especially if you have been taking a diuretic (water pill). Make sure you know how you react to losartan before you drive, use machines, or do anything else that could be dangerous if you are dizzy. Check with your doctor right away if you become sick while taking losartan, especially with severe or continuing nausea and vomiting or diarrhea. These conditions may cause you to lose too much water and lead to low blood pressure. Dizziness, lightheadedness, or fainting may also occur if you exercise or if the weather is hot. Heavy sweating can cause loss of too much water and result in low blood pressure. Use extra care during exercise or hot weather. Avoid alcoholic beverages until you have discussed their use with your doctor. Alcohol may make the low blood pressure effect worse and/or increase the possibility of dizziness or fainting.

SOLUTION FOR INJECTION

Flim And Flam - My Little Pony Friendship Is Magic Wiki, X-Flam

Flim and Flam

Contents

Development

Their names are a play on a flimflam. a confidence trick or a scam. "Skim" has various definitions and meanings.

In The Elements of Harmony guidebook. show writer M. A. Larson states, "I particularly enjoyed writing Flim and Flam. They are villains, but they are designed to be charming and disorienting. They speak very quickly. They finish each other's sentences. They're in constant motion. Everything they do is designed to dazzle and confuse people, so they can shake your hand while they're stealing your wallet. You can see their charm in action when the song ends and Apple Bloom is 100 percent ready to take their deal. This is the reaction the brothers are used to. In the midst of the song, one of the brothers confuses Applejack enough that she agrees to give them some apples for their demonstration. And when you're writing characters like that, their energy and optimism infuses the actual writing. I wrote that episode very quickly because their dialogue flew through my head as fast as it appears on-screen."

On Twitter in mid-December 2015, IDW comics writer Jeremy Whitley was asked, "Was there meant to be more done with Flim, Flam, Iron Will, and Lightning Dust that got cut? They just kinda. disappeared.", and replied, "I'd actually like to do a ff[ sic ] with LD and IW. I stand by Flim and Flam as unrepentant opportunists". [3]

Depiction in the series

Season two

"He's Flim!" "He's Flam!" "We're the world-famous Flim Flam Brothers!"

Flim and Flam first appear in The Super Speedy Cider Squeezy 6000 on their cider-making contraption of the same name and introduce themselves through song and dance. With Ponyville 's citizens faced with the dilemma of a limited quantity of manually pressed cider, they turn to Flim and Flam and their automated cider production. The brothers attempt to broker a deal with the Apple family to allow themselves business in Ponyville, calling for a 75-25 split in profits in their favor. When the Apples deny the offer, Flim declares that he and his brother will drive Sweet Apple Acres out of business.

The brothers return the next day and provoke the family into a cider-making competition to garner the rest of the town's favor, declaring that whoever produces the most barrels will be the winner. The Apple family uses manual labor to contend with the brothers, but Flim and Flam's technology overpowers them. Applejack 's friends offer their help to the Apple family, which the brothers permit, calling the Apples' tactics a lost cause. The additional help allows the family to produce barrels much faster and endanger the brothers' lead. In a panic, the brothers enhance their machine's suction and turn off its quality control setting, causing it to suck up whole trees, and pulping and mixing the apples with rocks and branches.

At the end of the competition, Flim and Flam have produced the most barrels and are declared the winners. However, their tactics have caused their cider to taste horrible, and all the ponies refuse to drink it. Realizing nobody in Ponyville wants to buy their product, Flim and Flam decide to try the next town over and beat a hasty retreat.

Season four

The Flim Flam Brothers marketing their "Miracle Curative Tonic".

The brothers return in Leap of Faith. this time selling a product called the "Flim Flam Miracle Curative Tonic", using a musical number to hype it as a panacea able to cure any ailment and injury, and even restore youth, among other outrageous claims. The tonic appears to work on a crutch-wielding volunteer in the audience, who casts off his crutches after drinking it; and later on Granny Smith. who overcomes her crippling fear of swimming.

Suspicious of Flim and Flam, Applejack visits the brothers' tent that night and discovers that the volunteer pony, Silver Shill. is part of the brothers' act to promote the tonic. When confronted by Applejack, the two partially admit that their tonic is a useless mixture of apple juice and beet leaves. However, they point out that Granny Smith's blissful ignorance of the tonic's true nature is allowing her to relive her youth as an aquapony, and guile Applejack into silence by suggesting that she would be denying her grandmother that happiness if the truth is revealed.

The next day, Flim and Flam sell their entire stock of tonic to Granny Smith for her to perform at the Ponyville Swim Meet, while Applejack unwittingly approves of its apparent beneficial effects, boosting their credibility. They set up shop at the swimming competition, promoting Silver Shill to help sell their tonic. However, Applejack realizes the bad example her dishonesty is setting for others and, after stopping Granny Smith from performing a dangerous high diving stunt, reveals that the tonic is fake. The brothers try to save face by endorsing the tonic's placebo effects, but Silver Shill, inspired by Applejack's honesty, intervenes and further confirms the brothers' schemes. Defeated again, Flim and Flam hastily flee Ponyville before anyone notices their absence.

The brothers appear in a flashback from this episode in Twilight's Kingdom - Part 1.

Season five

In one of the altered versions of the timeline, Flim and Flam change Equestria for their liking.

Season six

The Flim Flam Brothers in Viva Las Pegasus.

In Viva Las Pegasus. Flim and Flam appear as employees at Gladmane 's resort in Las Pegasus. However, the two opposingly sell performance tickets to ponies and frequently argue. When Applejack and Fluttershy are sent to Las Pegasus by the Cutie Map and find the two arguing, Fluttershy believes they were sent to help the two settle their differences, but Applejack refuses due to her past history with the brothers.

Through their individual investigations, Applejack and Fluttershy discover that resort owner Gladmane is intentionally causing arguments between the two brothers, as well as other resort employees, in order to keep them working for him. They inform Flim and Flam of Gladmane's trickery, and Flim and Flam help them expose his lies. After Gladmane is publicly disgraced and driven out of management, Flim and Flam take over ownership of the resort.

Depiction in Rainbow Rocks

The human counterparts of Flim and Flam appear in the short A Case for the Bass. where they run a pawn shop called "The Flim Flam Brothers' Everything-Under-The-Sun Emporium". The brothers try to swindle Applejack when she comes to retrieve her bass guitar that Granny Smith had accidentally sold them at a garage sale for two dollars. When Applejack proves her ownership of the bass, the two compromise her into working as their costumed spokesperson to pay off the instrument.

Depiction in comics

Flim and Flam in Friendship is Magic Issue #10.

Flim and Flam are mentioned in IDW comics ' My Little Pony Micro-Series Issue #3. having swindled characters Flax Seed and Wheat Grass into surrendering the land their spa is built on.

They also appear in My Little Pony: Friendship is Magic Issue #10. selling parasprite repellent.

Flim and Flam appear again in My Little Pony Micro-Series Issue #10. shown to have swindled Flax Seed and Wheat Grass out of their cart and another pony out of her sheep 's wool. Princess Luna has Flim and Flam return the goods to all the ponies they had conned.

On Friendship is Magic Issue #18 page 12, alternate versions of Flim and Flam appear in a stained glass window labeled "Fairness". They are depicted wearing robes with a judge's gavel and the scales of justice.

In Friends Forever Issue #9. Flim and Flam have a heated falling-out due to their fighting over a mare in Dodge Junction. At Apple Con 45, they promote their products separately. Granny Smith, initially suspicious of the brothers' motives, helps them reconcile because to her there's nothing more important or valuable than family.

In Friendship is Magic Issue #34. Flim and Flam are recruited by Radiant Hope to orchestrate an attack on the Crystal Empire. using their Super Speedy Cider Squeezy 6000 as a Trojan horse to smuggle changelings in. Over the course of the following issues, they are captured by the Mane Six and freed by King Sombra. By Issue #36. they begin to have second thoughts about their role in the invasion.

Merchandise

Flim Skim and Flam mini-figure toys and collector cards are included in the eighth wave of mystery packs, [4] which feature the brothers on their packaging; [5] the Flim Skim toy was displayed at the 2013 New York Toy Fair. [6] According to Flim Skim's collector card, "FLIM SKIM of the Flim Flam Brothers loves to sing!" And according to Flam's collector card, "FLAM of the Flim Flam Brothers loves apple cider!"

In the Friendship is Magic Collection of toy sets, a mini-figure toy of Flam is packaged in one of six Story Packs, [7] and a mini-figure toy of Flim is packaged with the Super Speedy Cider Squeezy 6000. [8]

Other depictions

In Fluttershy and the Fine Furry Friends Fair Flim and Flam run the "Farnum and Failey's Top Hat Bunny Cabaret".

In Lyra and Bon Bon and the Mares from S. M.I. L.E. . it is mentioned that Flim and Flam were briefly S. M.I. L.E. agents, but because they kept erasing each other's memories with their Reflection Deflections, they were dismissed from the agency.

HubNetwork. com description

Flim and his mustachioed brother Flam ride into town on their Super Speedy Cider Squeezy 6000. Doing a song and dance, these fast-talking salesponies challenge the Apple family to a cider-making contest. They win, but when everypony wises up to these Unicorns' wily ways -- the cider tastes awful! -- Flim and Flam hightail it out of town… perhaps to return again one day.

My Little Pony mobile game description

Flim . The brother of fellow salespony Flam, Flim sings and dances his way into Ponyville and attempts to sell low-quality cider, among other things! Flam . A traveling salespony, Flam has a mustache and can be found running the Balloon Pop Stand with his brother Flim.

According to the mobile game. Flim and Flam live in the cider machine. A promotional image posted by the official Facebook page of the game on May 27, 2014 [9] uses fanart of the two Flim Flam Brothers, [10] an edited version of the Flim part of which is to be used in the game itself. [11]

The Elements of Harmony guidebook

The FLIM FLAM BROTHERS are a pair of salespony tricksters who travel from town to town, using song and dance to trick ponies into buying their wares. But it's all just a sham—the Unicorn duo are often run right out of town when their faulty products and shady tricks are revealed!

Quotes

" Don't worry, everypony, there are plenty of apples in Equestria. We'll find some others and make more cider than all of Ponyville can drink! " — Flim, The Super Speedy Cider Squeezy 6000 " With our machine, we can make enough cider in one hour to satisfy this entire town! " — Flam, The Super Speedy Cider Squeezy 6000 " Congratulations, Granny Smith! You just made the purchase of a lifetime! " — Flim talking to Granny Smith. Leap of Faith " Hypothetically. " — Flam, Leap of Faith " Theoretically. " — Flim, Leap of Faith " Buy it now while supplies last. " — Flam, Leap of Faith " That could mean anything. " — Flam, A Case for the Bass " Flim Flam's Miracle Curative Tonic! Buy it now, while supplies last. " — Enterplay collectible card game ? #155 U card of Flim

Gallery

See also

References

Welches Image Hat Anginovag, Anetocain

?Que es, a dia de hoy, un negocio sin pagina web? ?Acaso queda alguno? Ya no es simplemente una cuestion de funcionabilidad, si no tambien de imagen. ?Cuanta fiabilidad ofrece una empresa que no se comunica por Internet? Pues cada vez menos.

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El martes me comenzo a doler la garganta pero no le di importancia pues pensaba que rea un resfriado y el miercoles apenas si podia hablar de la hinchazon de

Desde que llegue a Shanghai no he parado de tener infecciones de anginas. esta manana me he levantado con la garganta un poco rara y me ha entrado el panico!!En la ofi Sunny me ha ofrecido un jarabe de HK muy famoso en China. el packaging me ha fascinado. Su olor y.

Consejos de farmacia y algo mas, de todo un poco como en botica. Blog en el que encontraras consejos farmaceuticos sobre salud, belleza y bienestar, ademas de las farmacias de guardia

Kop Clognil (Plavix) Utan Recept, Clognil

Kopa Clognil (Plavix) Natet Utan Recept

Clognil (Plavix) Forklaring

Clognil fokuserar pa kan vara avhjalpa kardiovaskulara overgrepp samt gungor genom att stoppa blodet koagulerar. Dessutom det levereras for att undvika nagra andra kardiovaskulara eller till blodomloppet problem.

Clognil ar faktiskt utfor genom att stoppa blodet koagulerar. Det ar verkligen trombocythammande fastighetsmaklare.

Clognil kan ocksa hanvisas till som Clopidogrel, Clopitab, Caplor, Iscover Clopilet, Ceruvin.

Allmant titeln i samband med Clognil ar faktiskt Clopidogrel.

Brand i samband med Clognil ar faktiskt Clognil.

Clognil (Plavix) Dose

Clognil kommer in:

75mg Regular Dos friktionsmaterial

Get Clognil samtidigt varje dag, utan eller med maltider.

Get Clognil piller genom munnen tillsammans med dricksvatten.

Om du vill astadkomma basta resultaten brukar inte sluta med Clognil helt plotsligt.

Clognil (Plavix) I brist forknippas med doserings

Vanligtvis far inte dubbel dos. Om du hoppar over dosen du behover for att bara den nar du kom ihag nar det galler din saknas. Nar det ar dags for dosering du behover bara pa din egen normal dosering rutin.

Clognil (Plavix) Overdosering

Om du overdoserar Clognil och du undviker ocksa stor att du behover kolla din lakare eller ens lakare omedelbart. Forknippas med Clognil overdosering: kasta upp, oregelbundna blodningar eller till och med upphojningar, problem med inandning och utandning.

Clognil (Plavix) Lagringsutrymme

Shop i rymden temperaturer mellan 10 och 30 nivaer D (59 samt 86 nivaer F) fran fukt och temperatur. Starka nagon form av orord medicinering efter utgangen dagen. Behall fran uppna av barn inom en textruta som smabarn inte kan oppna.

Clognil (Plavix) Negativa effekter

Clognil erbjuder de negativa effekterna. Den mest typiska tenderar att vara:

tappt eller ens nasal nasal omrade friktionsmaterial

magen obehag friktionsmaterial

varkande tonsiller friktionsmaterial

hosta friktionsmaterial

huvudvark friktionsmaterial

diarre friktionsmaterial

trotthet friktionsmaterial

Mycket mindre vanliga och allvarliga negativa effekter i hela anvander Clognil:

allergiska reaktion reaktioner (urtikaria, andas in och andas problem, allergi, samt utbrott) friktionsmaterial

vekling, stanna eller till och med morka barstolar friktionsmaterial

problem med intag eller inandning och utandning friktionsmaterial

hjartproblem friktionsmaterial

unstopping blodforlust friktionsmaterial

ovantad huvudvark friktionsmaterial

husky tonfall friktionsmaterial

illamaende eller krakningar friktionsmaterial

viss svaghet friktionsmaterial

svett friktionsmaterial

problem med peeing friktionsmaterial

problem med syn, tal, eller till och med stabilitetsfriktionsmaterial

enkel blodning eller blamarken friktionsmaterial

varm friktionsmaterial

missforstand friktionsmaterial

gulsot friktionsmaterial

Negativa effekter indikationer lita pa medicin du kanske anvander men dessutom lita pa ditt valbefinnande villkor och en annan aspekter.

Clognil (Plavix) Kontraindikationer

Vanligtvis inte far Clognil om du ar kanslig for att Clognil element.

Vanligtvis far inte Clognil om du vantar annars du tanker ha ett barn, annars ar du verkligen en medicinsk mamma.

Var forsiktig tillsammans med Clognil om du drabbas av och har en kort historia i samband med hjartslag, magen magsar eller ulceros kolit; lever orgel eller ens renal sjukdom, blodarsjuka.

Var forsiktig tillsammans med Clognil om du anvander denna typ av mediciner eftersom acetylsalicylsyra eller ens nagra andra NSAID (icke-steroida antiinflammatoriska lakemedel till exempel naproxen (Aleve, Naprosyn), diklofenak (Voltaren), diflunisal (Dolobid), etodolac (Jod), flurbiprofen (Ansaid), indometacin (Indocin), ibuprofen (Motrin, Alvedon), (Toradol), ketoprofen (Orudis), nabumeton (Relafen), piroxikam (Feldene), ketorolak mefenamic surhetsgrad ( Ponstel), meloxikam (Mobic) och aven andra), fenytoin (sa eftersom Dilantin); torsemid (sa eftersom Demadex); medicin anvands for att undvika att blodet koagulerar (alteplas (sa eftersom Activase), anistreplas (sa eftersom Eminase), dipyridamol (sa eftersom Persantine), streptokinas (sa eftersom Kabikinase, Streptase), tiklopidin (Ticlid) samt urokinas (sa eftersom Abbokinase). fluvastatin (t. ex. darfor att Lescol), blodomloppet smalare (warfarin (sa eftersom Waran), heparin, ardeparin (sa eftersom Normiflo), dalteparin (t. ex. darfor att Fragmin), danaparoid (sa eftersom Orgaran), enoxaparin (sa eftersom Lovenox), eller aven tinzaparin (sa eftersom Innohep), tamoxifen (sa eftersom Nolvadex). tolbutamid (sa eftersom Orinase)

Det ar langt ifran foreslog att utfora idrottsverksamhet medan du anvander Clognil eftersom det kan orsaka blodforlust eller ens gupp skador.

Om du vill ha en kirurgisk behandling som du behover for att sluta med Clognil avseende fem ganger innan den kirurgiska behandlingen.

Vanligtvis inte utnyttjar kalium kosttillskott eller ens natrium alternativ.

Om du vill astadkomma basta resultat med nagra negativa effekter ar det lampligt att undvika alkoholhaltiga drycker.

Vanligtvis inte sluta anvanda Clognil helt plotsligt.

Clognil (Plavix) Vanliga fragor

Queen: Vad exakt ar Clognil negativa effekter?

Clognil erbjuder de typiska negativa effekterna till exempel tappt eller nasal nasal omrade, magen obehag, varkande tonsiller, hosta, huvudvark, diarre, trotthet. Men i situationen i samband med att bli avvisad i samband med Clognil komponenter du har mojlighet att mota mer allvarliga negativa effekter: vekling, tjarartade eller till och med morka barstolar, problem med viktminskningar eller ens andas in och andas, hjartproblem, unstopping blodforlust, ovantad huvudvark, husky tonfall, illamaende eller krakningar, vissa svaghet, svettning, problem med peeing, problem med syn, tal, eller till och stabilitet; enkel blodning eller blamarken, varma, missforstand, allergisk reaktion reaktion, gulsot. Risk for negativa effekter dyker upp beror pa wellness stallning samt, naturligtvis, om den korrekta efterfoljande Clognil recept medications. A

Queen: Vad exakt ar allmanna och varumarken som forknippas med Clognil?

Allman titeln i samband med Clognil ar faktiskt Clopidogrel. Brand i samband med Clognil ar faktiskt Clognil. A ??

Queen: Exakt hur ska jag fa Clognil?

Clognil kommer i piller (75 mg). Fa Clognil samtidigt varje dag, utan eller med maltider. Fa Clognil piller genom munnen tillsammans med dricksvatten. Om du vill uppna basta resultat brukar inte sluta med Clognil helt sudden. A

Queen: Exakt vad ska jag fag situationen i samband med overdos?

Vanligtvis inte far Clognil piller i stora mangder. I handelse av Clognil mer an dos, maste du kolla in lakare eller ens lakare instantly. A

Queen: Kan man verkligen konsumera alkohol?

Absolut ingen, det ar verkligen oacceptabelt uppskattar alkoholhaltiga beverages. A

Kop Clognil (Plavix) natet, kop Clognil (Plavix) Utan Recept, kop Clognil (Plavix) utan recept, kop Clognil (Plavix) billig, kopa Clognil (Plavix) utan recept, kop Clognil (Plavix) fran Kanada, kop Clognil (Plavix) Kanada, kopa Clognil (Plavix) natet, kopa Clognil (Plavix) natet utan recept, kopa Clognil (Plavix) utan recept, Clognil (Plavix) orala piller

Sok

Noritate (Metronidazole) Side Effects, Interactions, Warning, Dosage & Uses, Noritate

DRUG DESCRIPTION

NORITATE™ (metronidazole cream) Cream, 1%, contains metronidazole, USP. Chemically, metronidazole is 2-methyl-5-nitro-1H-imidazole-1-ethanol.

The molecular formula for metronidazole is C 6 H 9 N 3 O 3 .

Metronidazole has a molecular weight of 171.16. It is a white to pale yellow crystalline powder. It is slightly soluble in alcohol and has a solubility in water of 10 mg/mL at 20°C. Metronidazole is a member of the imidazole class of anti-bacterial agents and is classified as an antiprotozoal and anti-bacterial agent.

NORITATE (metronidazole) is an emollient cream; each gram contains 10 mg micronized metronidazole USP, in a base of purified water USP, stearic acid NF, glyceryl monostearate NF, glycerin USP, methylparaben NF, trolamine NF and propylparaben NF.

What are the possible side effects of metronidazole topical (MetroCream, MetroGel, MetroLotion, Noritate)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor if you have severe stinging or burning when you apply metronidazole topical.

Less serious side effects may include:

mild burning or stinging when the medication is applied;

numbness or tingly feeling in your hands or feet;

cough, stuffy nose, sore throat, cold symptoms;

vaginal itching or.

What are the precautions when taking metronidazole (Noritate)?

Before using metronidazole, tell your doctor or pharmacist if you are allergic to it; or to other nitroimidazole antibiotics (such as tinidazole); or to other ingredients in this product; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood disorders (blood dyscrasias).

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

This drug passes into breast milk. Discuss the risks and benefits with your doctor before.

Last reviewed on RxList: 12/8/2004 This monograph has been modified to include the generic and brand name in many instances.

Clases De Ged En Espanol, Para-G

Portland Community College

El Programa de GED en Espanol de Portland Community College les ofrece clases en el condado de Washington, el noreste y sureste de Portland. Estas clases preparan al alumno para tomar la version en Espanol del examen de GED. Todas las clases de GED en Espanol son ensenadas en Espanol.

La mayoria de empleadores y programas de entrenamiento, colegios y universidades aceptan el certificado de GED como una equivalencia por el certificado de preparatoria.

?Donde ofrecen las clases de GED en Espanol?

El programa de GED en Espanol de Portland Community College les ofrece clases en el condado de Washington, el noreste y sureste de Portland. Las clases estan disponibles en las mananas, en las tardes y varios dias de la semana.

?Como se registra uno para las clases de GED en Espanol?

Todos los alumnos nuevos deben tomar una prueba de admision (diagnostico) antes de registrarse para las clases de GED. Para mas informacion acerca de las fechas para tomar la prueba de admision y registrarse, favor de visitar ABE Orientation & Placement Sessions calendario y buscar los siguientes eventos:

Willow Creek Spanish GED Assessment & Registration (en Beaverton)

or

SE Campus Spanish GED Assessment & Registration (en Portland)

Los alumnos pueden tambien comunicarse con la linea de GED en Espanol llamando al 971-722-6219. Tenga en cuenta que no es requisito tomar las clases de preparacion de GED para poder tomar las pruebas de GED y obtener el diploma.

?Cuanto cuestan las clases de GED en Espanol?

Las clases de GED en Espanol cuestan entre $52 y $61 dolares por un curso de diez semanas. Las clases estan disponibles por las mananas y las tardes, y varios dias a la semana. Las inscripciones se pagan en la oficina de negocios de PCC.

?Hay clases de GED en Espanol disponibles en el internet?

Actualmente, el programa de GED en Espanol no ofrece cursos de GED en Espanol por internet.

?Como se pueden tomar los examenes de GED en Espanol?

Antes de tomar los examenes de GED, un alumno tiene que:

Registrarse en linea en la siguiente pagina web asegurandose de contestar todas las preguntas cuidadosamente. Necesitara una cuenta de email para poder registrarse: https://ged. com

Despues de registrarse, puede hacer citas (en linea) para tomar las pruebas. Debe estar preparado para pagar de una vez usando una tarjeta debito, una tarjeta de credito o ingresando el codigo de su voucher (en caso de que tenga uno). Tenga en cuenta que los prueba se pueden pagar por separado y el valor de cada prueba es $38. En total son cuatro pruebaes, ya que escritura y lectura se combinan ahora en un solo examen.

Para instrucciones detalladas de como registrarse y hacer citas puede visitar: http://www. gedtestingservice. com/testers/test-on-computer-tutorials. Esta pagina tambien incluye un ejemplo del prueba de GED en computador.

Es muy importante que entienda las politicas de cambio o cancelacion de citas para pruebaes. Esta informacion estara incluida en un email de confirmacion que recibira despues de hacer su cita. Cualquier reembolso debe ser solicitado al menos 24 horas antes de la cita. Para cambios o cancelaciones debe contactar a Pearson VUE Customer Service o llamar al 1-877-392-6433, no a al centro de pruebas PCC.

A partir del 2014, ya no es necesario asistir a una orientacion en el Centro de Pruebas de PCC (GED Testing Center) antes de tomar los pruebas.

?Cuanto tiempo se tarda para realizar el examen de GED?

El tiempo para realizar los examenes de GED depende del nivel de la habilidad, asistencia en las clases y la dedicacion del alumno para estudiar. Cada alumno es unico y varia la cantidad de tiempo requerido, para pasar los examenes de GED depende del alumno.

?Hay diferencias entre los examenes de GED en Espanol e ingles?

No. Ambos certificados de GED son identicos y no se indica en cual idioma el alumno tomo el examen.

?Hay libros y cursos disponibles en el internet para estudiar GED en Espanol?

Hay libros de GED en Espanol que estan disponibles en las librerias de Rock Creek. Cascade. y SE Campus .

Tambien, los siguientes recursos en linea pueden ser utiles para ayudarle a prepararse para los examenes de GED en Espanol.

?Como se puede asistir al colegio gratis despues de conseguir el certificado de GED en Espanol?

Los alumnos que se graduan del programa de GED en Portland Community College son elegibles para recibir 12 creditos gratis de clases de colegio. Para mas informacion y detalles acerca de este programa comuniquese con: Vanessa Hernandez .

Related Pages

Irumed - Instructions For Use, Description Medicines, Irumed

IRUMED

Excipients: mannitol, Calcium phosphate dihydrate, corn starch, pregelatinized corn starch, dye iron oxide yellow (E172), iron oxide red dye (E172), colloidal silicon dioxide, magnesium stearate.

30 PC. – blisters (1) – packs cardboard.

Pharmacological action

ACE inhibitor. Antihypertensive drugs. The mechanism of action is associated with inhibition of ACE activity, which leads to suppression of the formation of angiotensin II from angiotensin I and to the direct reduction of aldosterone release. It reduces the degradation of bradykinin, and increases the synthesis of prostaglandins.

Reduces PR, FROM, preload, the pressure in the pulmonary capillaries, It causes an increase in cardiac output and increase exercise tolerance in patients with chronic heart failure. Lisinopril exerts vasodilating effects, wherein the artery expands to a greater extent, than veins. Some effects are explained by the influence on the tissue renin-angiotensin system. It improves blood flow to ischemic myocardium. Prolonged use reduces myocardial hypertrophy and arterial walls resistive type.

The use of ACE inhibitors in patients with chronic heart failure leads to an increase in life expectancy; patients, myocardial infarction, without clinical symptoms of heart failure – to slow the progression of left ventricular dysfunction.

The onset of action observed after 1 h after dosing, maximum effect through 6-7 no, duration – 24 no. When hypertension effect observed in the first days after the start of treatment, stable operation is developed through 1-2 of the month.

With a sharp lifting of the drug was not observed pronounced increase in blood pressure. In addition to lowering blood pressure, lisinopril reduces albuminuria. Patients with hyperglycemia helps normalize the function of the damaged glomerular endothelial. Lisinopril does not affect the concentration of glucose in the blood plasma of patients with diabetes, and does not lead to increased incidence of hypoglycemia.

Pharmacokinetics

After oral administration about 25% lisinopril is absorbed from the gastrointestinal tract. Food intake has no effect on the absorption of lisinopril. Absorption averages 30%. Bioavailability – 29%. C max in plasma is approximately 6-8 no.

Weakly bound to plasma proteins. Lisinopril slightly penetrate the BBB, the placental barrier.

T 1/2 – 12 no. Lisinopril is not metabolised and is excreted unchanged in the urine.

INDICATIONS

- Arterial hypertension (alone or in combination with other antihypertensives);

- Congestive heart failure (in a combination therapy for the treatment of patients, taking drugs digitalis and / or diuretics);

- Early treatment of acute myocardial infarction (as part of combination therapy in the first 24 hours in patients with stable hemodynamic parameters, to maintain these parameters and prevent left ventricular dysfunction and heart failure);

- Diabeticheskaya nephropathy (to reduce albuminuria in insulin-dependent patients with normal blood pressure and insulin dependent patients with hypertension).

DOSAGE

The drug is prescribed inside. Eating does not affect the absorption, so the drug can be taken up, during or after a meal. Multiplicity of reception 1 time / day (at about the same time).

At treatment of essential hypertension It recommended to prescribe a starting dose 10 mg. The maintenance dose is 20 mg / day. The maximum daily dose – 40 mg. For the full development of the effect may require 2-4-week course of treatment (it should be taken into account when the dose is increased). If the application of the highest dose not causing a sufficient therapeutic effect, the possible appointment of additional other agents.

Patients, taking diuretics, Treatment with diuretics should be discontinued 2-3 days before the start of treatment Irumedom ®. Patients, from which it is impossible to stop treatment with diuretics, Irumed ® administered in an initial dose of 5 mg / day.

At renovascular hypertension or other conditions with increased function of the renin-angiotensin-aldosterone system Irumed ® administered in an initial dose of 2.5-5 mg / day under the control of blood pressure, renal function, potassium concentration in blood serum. Maintenance dose is adjusted depending on the blood pressure.

In patients with renal insufficiency and patients, hemodialysis . initial dose set depending on QC. Maintenance dose is determined depending on the blood pressure (under the control of renal function, Sodium and potassium levels in the blood).

The initial daily dose

At chronic heart failure Lisinopril use may simultaneously with diuretics and / or cardiac glycosides. If possible, the diuretic dose should be reduced prior to receiving lisinopril. The initial dose is 2.5 mg 1 time / day, further gradually increased (on 2.5 mg after 3-5 days) to 5-10 mg / day. The maximum dose – 20 mg / day.

At acute myocardial infarction (as part of combination therapy in the first 24 h in patients with stable hemodynamics) first 24 h prescribed 5 mg, then – 5 mg a day, 10 mg – two days later, and then – 10 mg 1 time / day. In patients with acute myocardial infarction drug is used for 6 weeks. At the start of treatment or during the first 3 days after acute myocardial infarction patients with low systolic blood pressure (120 mmHg. or below) the drug is prescribed in a dose 2.5 mg. In case of arterial hypotension (systolic blood pressure less than or equal 100 mmHg.) daily dose 5 mg can be temporarily reduced to 2.5 mg. In the case of longer hypotension (systolic BP below 90 mmHg. more 1 no) reception Irumeda ® discontinue.

At diabetic nephropathy in patients with diabetes mellitus type 1 (insulin) Irumed ® administered at a dose of 10 mg 1 time / day. If necessary, the dose can be increased to 20 mg / day to achieve diastolic BP values ??below 75 mmHg. in the sitting position. In patients with diabetes mellitus type 2 (insulinnezavisimym) The same dose to achieve diastolic BP values ??below 90 mmHg. in the sitting position.

SIDE EFFECT

Frequently: dizziness, headache, fatigue, diarrhea, dry cough, nausea.

Cardio-vascular system: marked reduction in blood pressure, chest pain; rarely – orthostatic hypotension, tachycardia, bradycardia, worsening symptoms of heart failure, violation of AV-conduction, myocardial infarction.

From the central and peripheral nervous system: mood lability, perplexity, paresthesia, drowsiness, jerking of the limbs and lips; rarely – asthenic syndrome.

From the digestive system: dry mouth, anorexia, dyspepsia, change in taste, abdominal pain, pancreatitis, hepatocellular or cholestatic, jaundice, hepatitis, increase in liver transaminases, giper?iliru?inemija.

The respiratory system: dyspnoea, bronchospasm.

Dermatological reactions: increased perspiration, itching, alopecia, photosensitivity.

From the side of hematopoiesis: leukopenia, thrombocytopenia, neutropenia, agranulocytosis, anemia (decrease in hematocrit, Hemoglobin, erythropenia).

Metabolism: hyperkalemia, giponatriemiya, hyperuricemia, increase of blood creatinine.

From the urinary system: impairment of renal function, oligurija, anurija, uremia, proteinemiya.

Allergic reactions: hives, angioneurotic edema of the face, limbs, lips, language, epiglottis and / or larynx, skin rash, itch, fever, test positive for antinuclear antibodies, increased erythrocyte sedimentation rate, eozinofilija, leukocytosis; in some cases – Interstitial angioedema.

Other: arthralgia / arthritis, myalgia, vasculitis, reduced potency.

CONTRAINDICATIONS

- A history of angioedema (incl. the application of ACE inhibitors);

- Hereditary angioedema or idiopathic edema;

- Up to 18 years (efficacy and safety have not been established);

- Hypersensitivity to lisinopril other ACE inhibitors;

FROM caution should be prescribed the drug for aortic stenosis, cerebrovascular diseases (incl. cerebrovascular insufficiency), CHD, coronary insufficiency, severe autoimmune systemic diseases of connective tissue (incl. SLE, scleroderma), the oppression of bone marrow hematopoiesis, diabetes, hyperkalemia, bilateral renal artery stenosis, stenosis of the artery to a solitary kidney, if condition after kidney transplantation, renal failure, azotemii, primary hyperaldosteronism, hypotension, hypoplasia of the bone marrow, hypertrophic obstructive cardiomyopathy, hypotension, against a diet restricted salt, states, accompanied by a decrease in the bcc (incl. diarrhea, vomiting), elderly patients.

Pregnancy and lactation

Application Irumeda ® Pregnancy and lactation (breast-feeding) contraindicated.

Lisinopril crosses the placental barrier. In the event of pregnancy treatment Irumedom ® should cease immediately. ACE inhibitors in the II and III trimester of pregnancy can cause the death of the fetus and newborn. Newborns can develop skull hypoplasia, oligogidramnion, deformation of the bones of the skull and face, pulmonary hypoplasia, violation of kidney. For newborns and babies, whose mothers during pregnancy, ACE inhibitors, careful monitoring is recommended for early detection of significant decrease in blood pressure, oligurii, hyperkalemia.

No data on the penetration of lisinopril in breast milk. During treatment with Irumed ® breastfeeding should be abolished.

Cautions

It should be taken into account, marked reduction in blood pressure that occurs with a decrease in the volume of liquid, caused by diuretic therapy, while reducing salt in foods, during dialysis in patients with diarrhea or vomiting. Patients with chronic heart failure with simultaneous renal insufficiency or without may develop symptomatic hypotension, which is often seen in patients with severe heart failure, as a consequence of the use of high doses of diuretics, hyponatremia or impaired renal function. In these patients, treatment should start under close medical supervision (with caution in the selection of dose and diuretics). This tactic should be followed in the appointment of Irumeda ® patients with coronary artery disease, cerebrovascular insufficiency, in which the sharp decline in blood pressure can lead to heart attack or stroke.

In the case of significant decrease in blood pressure patient should be given a horizontal position and, if necessary, in / enter 0.9% sodium chloride solution. Transient hypotensive response is not a contraindication to receiving the next dose.

When using Irumeda ® in some patients with chronic heart failure, but with normal or low blood pressure may experience a decrease in blood pressure, which is usually not a cause for discontinuation of treatment. When, If hypotension becomes symptomatic, you need to decrease the dose or discontinuation of treatment Irumedom ® .

In acute myocardial infarction shows the use of standard therapy (thrombolytics, acetylsalicylic acid, beta-blockers). Irumed ® It can be applied in conjunction with / in the introduction or use of transdermal nitroglycerin systems.

Irumed ® should not be administered to patients with acute myocardial infarction, in which there is a risk of further deterioration of the hemodynamic expressed after application of vasodilators: patients with systolic blood pressure 100 mmHg. or below, or cardiogenic shock.

In patients with chronic heart failure, marked reduction in blood pressure after initiation of therapy with ACE inhibitors may result in further deterioration of renal function. Cases of acute renal failure. In patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney, ACE inhibitor, was an increase in urea and serum creatinine, usually reversible upon discontinuation of treatment (more frequent in patients with renal insufficiency).

Lisinopril is not indicated for acute myocardial infarction in patients with severe renal impairment with serum creatinine content 177 mmol / l or more proteinuria 500 mg / day. If renal dysfunction develops during treatment with the drug (of serum creatinine 265 mmol / l or increase in 2 times, as compared with before treatment), It should assess the need to continue therapy with Irumed ® .

Patients, taking ACE inhibitors, including lisinopril, rarely develop angioedema face, limbs, lips, language, epiglottis and / or larynx, and its development is possible at any time during treatment. In this case, treatment Irumedom ® as soon as possible to stop the sick and set up observation of complete regression of symptoms. However, in cases, When swelling occurs only on the face and lips and most of the state is normalized without treatment, possible appointment of antihistamines.

In the propagation of the language of angioedema, epiglottis or larynx may occur airway obstruction fatal, why you should immediately conduct appropriate therapy (0.3-0.5 ml 1:1000 epinephrine solution n / a) and / or measures to ensure airway. Noted, that patients with blacks, taking ACE inhibitors, angioneurotic edema develops most, than patients of other races. Patients, a history which has been angioedema, not related to previous treatment with an ACE inhibitor, It may be at increased risk of its development during treatment Irumedom ® .

Patients, taking ACE inhibitors, during desensitization to Hymenoptera venom (this, Bees, Ants), rarely may develop anaphylactoid reactions. This can be avoided, if temporarily discontinue treatment with an ACE inhibitor prior to each desensitization.

It should be taken into account, that patients, taking ACE inhibitors and undergoing hemodialysis using highly permeable dialysis membranes (eg, AN69), can develop an anaphylactic reaction. In such cases it is necessary to consider the use of another type of membrane dialysis or other antihypertensives.

When using ACE inhibitors observed cough (dry, long, which disappears after discontinuation of treatment with an ACE inhibitor). In the differential diagnosis of cough and cough should be considered, resulting from the use of an ACE inhibitor.

When using drugs, lowering blood pressure, in patients with extensive surgery or during general anesthesia lisinopril may block the formation of angiotensin II, secondary to compensatory renin release. Marked decrease in blood pressure, which is considered a consequence of this mechanism, You can eliminate the increase in BCC. Before surgery (including dental surgery) should inform the surgeon / anesthesiologist on the use of an ACE inhibitor.

In some cases, there is hyperkalemia. Risk factors for the development of hyperkalemia include renal insufficiency, diabetes mellitus, and the simultaneous use of potassium-sparing diuretics (spironolactone, triamterene or amiloride), drugs or potassium salt substitutes, containing potassium, especially in patients with impaired renal function. If necessary, the application of these combinations should regularly monitor the level of potassium in the blood serum.

Patients, in which there is a risk of symptomatic hypotension (are on a salt-free diet or malosolevoy) with / without hyponatremia, and in patients, who received high doses of diuretics, above the state before treatment is necessary to compensate (loss of fluids and salts). It is necessary to monitor the effect of the initial dose Irumed ® the value of BP.

Effects on ability to drive vehicles and management mechanisms

No data on the effect Irumeda ®. used in therapeutic doses, the ability to drive vehicles and mechanisms, However, it should be taken into account, that may cause vertigo. Therefore, during treatment, patients should be careful when driving and work, require high concentration and speed of psychomotor reactions.

OVERDOSE

Symptoms: marked reduction in blood pressure, dry mouth, drowsiness, urinary retention, constipation, anxiety, irritability.

Treatment: symptomatic therapy, in / in a saline solution and, if necessary, the use of vasopressor agents under the control of blood pressure and water and electrolyte balance. Perhaps the use of hemodialysis.

Drug Interactions

In an application Irumeda ® with potassium-sparing diuretics (spironolactone, triamterene, amilorid), potassium supplements, salt substitutes, containing potassium, increased risk of hyperkalemia, especially in patients with impaired renal function.

In an application Irumeda ® diuretics observed marked reduction of blood pressure.

In an application Irumeda ® with other antihypertensive agents observed an additive effect.

In an application Irumeda ® NSAIDs, Estrogen, adrenostimulyatorov reduced antihypertensive effect of lisinopril.

In an application Irumeda ® lithium slows excretion of lithium from the body.

In an application Irumeda ® kolestiraminom with antacids and reduced absorption from the gastrointestinal tract of lisinopril.

Ethanol enhances the effect of the drug.

Conditions of supply of pharmacies

The drug is released under the prescription.

TERMS AND CONDITIONS OF STORAGE

List B. The drug should be stored out of reach of children at a temperature of 25 ° C. Shelf life – 2 year.

This entry was postedon Tuesday, October 5th, 2010 in 20:53 and is filed under Instructions for use, Description medicines. AND. You can follow any responses to this entry through the RSS 2.0 tape. You can leave a comment. or trackback from your site.

Lovette Videos And Photos (145) At Freeones, Lovette

Lovette Dashboard

Lovette Quick Bio Info

Babe Name: Lovette Aliases: Unknown (add ) Date of Birth: January 27, 1973 (43 years old) Place of Birth: South Bend Country of Origin: United States Career Status: Retired Eye Color: Blue Hair Color: Blonde Measurements: 44EE-25-35 Fake Boobs: Yes Piercings: Clithood; navel Tattoos: None

Lovette is a Porn Star from United States. She was born in South Bend on January 27, 1973. She is listed on FreeOnes since 2001 and is currently ranked 4221th place. She currently has 145 gallery links in her own FreeOnes section.

Our records show that Lovette is currently retired which means she is not making movies, doing live shows and/or doing photo shoots at this time.

New Lovette Links (145 )

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Latest Babe Comments (Showing 10 of 10 comments)

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Uzumaki Clan - Narutopedia, Karin

Uzumaki Clan

Contents

Overview

The Uzumaki and Senju after the creation of their villages.

The Uzumaki, being descendants of Asura Otsutsuki. also shared distant blood relation with the Senju clan. [2] Through the years, the Uzumaki and Senju kept close ties, with members at times marrying between clans, as with Hashirama Senju and Mito Uzumaki. [3] Following the founding of Konohagakure at the end of the Warring States Period. the Senju chose to symoblise their clans' friendship by adding the Uzumaki's emblem to Konoha's flak jackets. Konoha and the Uzumaki's own Uzushiogakure remained close allies over the following decades, with the Uzumaki providing fuinjutsu (among other things) to Konoha whenever there was a need. [4] In time, the Uzumaki Clan's Mask Storage Temple was even constructed on Konoha's outskirts. [5]

The Uzumaki's skill with fuinjutsu earned them both respect and fear throughout the ninja world. At some point after Kushina Uzumaki immigrated to Konoha, some of the world's nations banded together to destroy Uzushiogakure, believing the village was too powerful to be allowed to continue. The survivors of Uzushio's destruction went into hiding and spread throughout the world: [3] Nagato was raised in the outskirts of Amegakure ; Karin apparently lived in Kusagakure for a time; Kushina in Konoha, who had a son, Naruto. who years later has children of his own with his wife Hinata Hyuga. Boruto and Himawari. As a result, this has strengthened the Uzumaki clan's familial relation to the Hyuga Clan (the descendants of Asura's uncle, Hamura Otsutsuki ).

Abilities

The typical appearance of an Uzumaki fuinjutsu.

Uzumaki naturally possess incredibly strong life forces, granting them very long lifespans; [6] Mito Uzumaki was born before the founding of Konoha yet lived well into the reign of the Third Hokage. This also enables them to recover from injuries and exhaustion in short periods of time, enough to survive the removal of tailed beasts. although they are still left near death afterwards. [7] Uzumaki also have the ability to heal and rejuvenate allies by having their allies bite them and suck their chakra. [8] It is dangerous however to use this ability too regularly. At least one member has displayed a unique sensory ability.

The Uzumaki were most famed for their fuinjutsu, the seal of which typically appears as a spiral crest reminiscent of the Uzumaki's symbol. They can also produce the Adamantine Sealing Chains made from their own chakra, [9] [10] but it is unknown if this technique is common amongst the Uzumaki, as only Kushina and Karin have been shown to use it.

Known Leaders

Trivia

The name "Uzumaki" can either mean "whirlpool " or "maelstrom ".

Uzumaki commonly have red hair. [11]

Tsunade and Nawaki are descendants of the Uzumaki clan through their grandmother.

Due to Naruto Uzumaki's marriage to Hinata Hyuga. his descendants have the potential to awaken the Byakugan. [12]

The anime character Honoka is hinted to be an Uzumaki, as she has red hair and fuinjutsu talents. A book found by Aoba in the same episode mentions finding a survivor of a "certain clan of ninja". [13]

Menma Namikaze. another Genjutsu World counterpart of Naruto Uzumaki, is descendant of the Uzumaki clan by his mother.

References

Start a Discussion Discussions about Uzumaki Clan

QuakingStar wrote: Or it is possible Minato has Senju in his bloodline. It's that or what you said. @Makimaki11 Ise came from Uzushiogakure al. 2016-05-12T23:48:32Z

Ashina's hair was simply effected by old age, he was almost 70yrs old. 2016-05-12T23:51:19Z

Georgio722 wrote: I mean, Wood Release is like basically manipulating the Shinju's roots, or using the Shinju as the source for the wood. 2016-03-23T16:36:16Z

Legendary Super Saiya-Jin 4 wrote: Only two members of the Uzumaki Clan have the Adamantine Sealing Chains though as far as know though, and. 2016-03-24T07:41:02Z

Nizoral - Anti Fungal, Pelikair

Anti Fungal - Pelikair (Brand name: nizoral)

Product Description Common use Nizoral is an antifungal antibiotic used to treat serious fungal or yeast infections, such as candidiasis, blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis, or paracoccidioidomycosis. Nizoral kills sensitive fungi by interfering with the formation of the fungal cell membrane. Also Nizoral is used to treat parasitic fungal infections on the skin that cannot be treated with topical medicine or griseofulvin, or for patients who cannot take griseofulvin.

Dosage and direction Take it orally with food or milk at the same time each day. The recommended starting dose for adults is 200 mg once a day. Dosage for 2-year-old children is based on body weight. A single daily dose varies from 3.3 to 6.6 mg/kg. Do not use it without doctor's permission and dose has to be prescribed just after consulting your doctor. For children under the age of 2, use it just after doctor's permission and dose has to be prescribed after consulting your doctor. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using.

Precautions Liver problems may occur while you are taking this medicine. If you experience one of this symptoms as dark urine; abdominal pain or tenderness; clay-colored stools; nausea and vomiting; decreased appetite; skin rash; fever; headache; itching; loss of appetite; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin call your doctor immediately. Nizoral should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use this drug before breast-feeding without doctor's permission.

Nizoral is not allowed to people who are hypersensitive to any components of this medication. Also it is contraindicated with terfenadine, astemizole, triazolam, cisapride.

Possible side effect They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: dizziness, fainting, fast or pounding heartbeat; easy bruising or bleeding, unusual weakness; numbness or tingly feeling; severe depression, confusion, or thoughts of hurting yourself; or nausea, stomach pain, low fever, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious include: mild nausea, vomiting, or stomach pain; mild itching or skin rash; headache; dizziness; breast swelling; or impotence or loss of interest in sex. If you experience one of them stop using Nizoral and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Nizoral interact with follow list of drugs: acetaminophen (Tylenol); cyclosporine (Gengraf, Sandimmune, Neoral); digoxin (digitalis, Lanoxin); tacrolimus ((Prograf); loratadine (Alavert, Claritin, Tavist ND); methylprednisolone (Medrol); phenytoin (Dilantin); rifampin (Rifadin, Rifater, Rifamate, Rimactane); diabetes medication you take by mouth; a sedative such as midazolam (Versed); a blood thinner such as warfarin (Coumadin); cancer medications; birth control pills or hormone replacement therapy; methotrexate (Rheumatrex, Trexall); cholesterol medications such as niacin (Advicor), atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and others; or medications to treat HIV or AIDS. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.

Symptoms of Nizoral overdose are not known well, but if you experience any unusual symptoms call your doctor immediately. Also in the event of accidental over-dosage, supportive measures, including gastric lavage with sodium bicarbonate, should be employed.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Product Description Common use Nizoral is an antifungal antibiotic used to treat serious fungal or yeast infections, such as candidiasis, blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis, or paracoccidioidomycosis. Nizoral kills sensitive fungi by interfering with the formation of the fungal cell membrane. Also Nizoral is used to treat parasitic fungal infections on the skin that cannot be treated with topical medicine or griseofulvin, or for patients who cannot take griseofulvin.

Dosage and direction Take it orally with food or milk at the same time each day. The recommended starting dose for adults is 200 mg once a day. Dosage for 2-year-old children is based on body weight. A single daily dose varies from 3.3 to 6.6 mg/kg. Do not use it without doctor's permission and dose has to be prescribed just after consulting your doctor. For children under the age of 2, use it just after doctor's permission and dose has to be prescribed after consulting your doctor. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using.

Precautions Liver problems may occur while you are taking this medicine. If you experience one of this symptoms as dark urine; abdominal pain or tenderness; clay-colored stools; nausea and vomiting; decreased appetite; skin rash; fever; headache; itching; loss of appetite; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin call your doctor immediately. Nizoral should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use this drug before breast-feeding without doctor's permission.

Nizoral is not allowed to people who are hypersensitive to any components of this medication. Also it is contraindicated with terfenadine, astemizole, triazolam, cisapride.

Possible side effect They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: dizziness, fainting, fast or pounding heartbeat; easy bruising or bleeding, unusual weakness; numbness or tingly feeling; severe depression, confusion, or thoughts of hurting yourself; or nausea, stomach pain, low fever, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious include: mild nausea, vomiting, or stomach pain; mild itching or skin rash; headache; dizziness; breast swelling; or impotence or loss of interest in sex. If you experience one of them stop using Nizoral and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Nizoral interact with follow list of drugs: acetaminophen (Tylenol); cyclosporine (Gengraf, Sandimmune, Neoral); digoxin (digitalis, Lanoxin); tacrolimus ((Prograf); loratadine (Alavert, Claritin, Tavist ND); methylprednisolone (Medrol); phenytoin (Dilantin); rifampin (Rifadin, Rifater, Rifamate, Rimactane); diabetes medication you take by mouth; a sedative such as midazolam (Versed); a blood thinner such as warfarin (Coumadin); cancer medications; birth control pills or hormone replacement therapy; methotrexate (Rheumatrex, Trexall); cholesterol medications such as niacin (Advicor), atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and others; or medications to treat HIV or AIDS. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.

Symptoms of Nizoral overdose are not known well, but if you experience any unusual symptoms call your doctor immediately. Also in the event of accidental over-dosage, supportive measures, including gastric lavage with sodium bicarbonate, should be employed.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Anti Fungal - Pelikair (Brand name: nizoral)

Product Description Common use Nizoral is an antifungal antibiotic used to treat serious fungal or yeast infections, such as candidiasis, blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis, or paracoccidioidomycosis. Nizoral kills sensitive fungi by interfering with the formation of the fungal cell membrane. Also Nizoral is used to treat parasitic fungal infections on the skin that cannot be treated with topical medicine or griseofulvin, or for patients who cannot take griseofulvin.

Dosage and direction Take it orally with food or milk at the same time each day. The recommended starting dose for adults is 200 mg once a day. Dosage for 2-year-old children is based on body weight. A single daily dose varies from 3.3 to 6.6 mg/kg. Do not use it without doctor's permission and dose has to be prescribed just after consulting your doctor. For children under the age of 2, use it just after doctor's permission and dose has to be prescribed after consulting your doctor. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using.

Precautions Liver problems may occur while you are taking this medicine. If you experience one of this symptoms as dark urine; abdominal pain or tenderness; clay-colored stools; nausea and vomiting; decreased appetite; skin rash; fever; headache; itching; loss of appetite; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin call your doctor immediately. Nizoral should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use this drug before breast-feeding without doctor's permission.

Nizoral is not allowed to people who are hypersensitive to any components of this medication. Also it is contraindicated with terfenadine, astemizole, triazolam, cisapride.

Possible side effect They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: dizziness, fainting, fast or pounding heartbeat; easy bruising or bleeding, unusual weakness; numbness or tingly feeling; severe depression, confusion, or thoughts of hurting yourself; or nausea, stomach pain, low fever, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious include: mild nausea, vomiting, or stomach pain; mild itching or skin rash; headache; dizziness; breast swelling; or impotence or loss of interest in sex. If you experience one of them stop using Nizoral and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Nizoral interact with follow list of drugs: acetaminophen (Tylenol); cyclosporine (Gengraf, Sandimmune, Neoral); digoxin (digitalis, Lanoxin); tacrolimus ((Prograf); loratadine (Alavert, Claritin, Tavist ND); methylprednisolone (Medrol); phenytoin (Dilantin); rifampin (Rifadin, Rifater, Rifamate, Rimactane); diabetes medication you take by mouth; a sedative such as midazolam (Versed); a blood thinner such as warfarin (Coumadin); cancer medications; birth control pills or hormone replacement therapy; methotrexate (Rheumatrex, Trexall); cholesterol medications such as niacin (Advicor), atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and others; or medications to treat HIV or AIDS. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.

Symptoms of Nizoral overdose are not known well, but if you experience any unusual symptoms call your doctor immediately. Also in the event of accidental over-dosage, supportive measures, including gastric lavage with sodium bicarbonate, should be employed.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Tamoxifen Medlineplus Drug Information, Tamoxifen Citrate

Tamoxifen

IMPORTANT WARNING:

Tamoxifen may cause cancer of the uterus (womb), strokes, and blood clots in the lungs. These conditions may be serious or fatal. Tell your doctor if you have ever had a blood clot in the lungs or legs, a stroke, or a heart attack. Also tell your doctor if you smoke, if you have high blood pressure or diabetes, if your ability to move around during your waking hours is limited, or if you are taking anticoagulants ('blood thinners') such as warfarin (Coumadin). If you experience any of the following symptoms during or after your treatment, call your doctor immediately: abnormal vaginal bleeding; irregular menstrual periods; changes in vaginal discharge, especially if the discharge becomes bloody, brown, or rusty; pain or pressure in the pelvis (the stomach area below the belly button); leg swelling or tenderness; chest pain; shortness of breath; coughing up blood; sudden weakness, tingling, or numbness in your face, arm, or leg, especially on one side of your body; sudden confusion; difficulty speaking or understanding; sudden difficulty seeing in one or both eyes; sudden difficulty walking; dizziness; loss of balance or coordination; or sudden severe headache.

Keep all appointments with your doctor. You will need to have gynecological examinations (examinations of the female organs) regularly to find early signs of cancer of the uterus.

If you are thinking about taking tamoxifen to reduce the chance that you will develop breast cancer, you should talk to your doctor about the risks and benefits of this treatment. You and your doctor will decide whether the possible benefit of tamoxifen treatment is worth the risks of taking the medication. If you need to take tamoxifen to treat breast cancer, the benefits of tamoxifen outweigh the risks.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with tamoxifen and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www. fda. gov/Drugs/DrugSafety/ucm085729.htm ) or the manufacturer's website to obtain the Medication Guide.

Why is this medication prescribed?

Tamoxifen is used to treat breast cancer that has spread to other parts of the body in men and women. It is used to treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. It is used to reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (DCIS; a type of breast cancer that does not spread outside of the milk duct where it forms) and who have been treated with surgery and radiation. It is used to reduce the risk of breast cancer in women who are at high risk for the disease due to their age, personal medical history, and family medical history.

Tamoxifen is in a class of medications known as antiestrogens. It blocks the activity of estrogen (a female hormone) in the breast. This may stop the growth of some breast tumors that need estrogen to grow.

How should this medicine be used?

Tamoxifen comes as a tablet to take by mouth. Tamoxifen is usually taken once or twice a day with or without food. Take tamoxifen at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain anything you do not understand. Take tamoxifen exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow tamoxifen tablets whole; do not split, chew, or crush them. Swallow the tablets with water or any other nonalcoholic drink.

If you are taking tamoxifen to prevent breast cancer, you will probably take it for five years. If you are taking tamoxifen to treat breast cancer, your doctor will decide how long your treatment will last. Do not stop taking tamoxifen without talking to your doctor.

If you forget to take a dose of tamoxifen, take the missed dose as soon as you remember it, and take your next dose as usual. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Other uses for this medicine

Tamoxifen is also used sometimes to induce ovulation (egg production) in women who do not produce eggs but wish to become pregnant. Tamoxifen is also sometimes used to treat McCune-Albright syndrome (MAS; a condition that may cause bone disease, early sexual development, and dark colored spots on the skin in children). Talk to your doctor about the possible risks of using this drug for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking tamoxifen,

tell your doctor and pharmacist if you are allergic to tamoxifen or any other medications.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglutethimide (Cytadren); anastrazole (Arimidex), bromocriptine (Parlodel); cancer chemotherapy medication such as cyclophosphamide (Cytoxan, Neosar) letrozole (Femara); medroxyprogesterone (Depo-Provera, Provera, in Prempro); phenobarbital; and rifampin (Rifadin, Rimactane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

in addition to the conditions listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had high blood levels of cholesterol.

tell your doctor if you are pregnant or plan to become pregnant. You should not plan to become pregnant while taking tamoxifen or for 2 months after your treatment. Your doctor may perform a pregnancy test or tell you to begin your treatment during your menstrual period to be sure that you are not pregnant when you begin taking tamoxifen. You will need to use a reliable nonhormonal method of birth control to prevent pregnancy while you are taking tamoxifen and for 2 months after your treatment. Talk to your doctor about the types of birth control that are right for you, and continue to use birth control even if you do not have regular menstrual periods during your treatment. Stop taking tamoxifen and call your doctor right away if you think you have become pregnant during your treatment. Tamoxifen may harm the fetus.

tell your doctor if you are breast-feeding. You should not breastfeed during your treatment with tamoxifen.

tell all of your doctors and other health care providers that you are taking tamoxifen.

you will still need to look for early signs of breast cancer since it is possible to develop breast cancer even during treatment with tamoxifen. Talk to your doctor about how often you should examine your breasts yourself, have a doctor examine your breasts, and have mammograms (x-ray examinations of the breasts). Call your doctor right away if you find a new lump in your breast.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Tamoxifen may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

increased bone or tumor pain

pain or reddening around the tumor site

hot flashes

nausea

excessive tiredness

dizziness

depression

headache

thinning of hair

weight loss

stomach cramps

constipation

loss of sexual desire or ability (in men)

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

vision problems

loss of appetite

yellowing of the skin or eyes

unusual bruising or bleeding

fever

blisters

rash

swelling of the eyes, face, lips, tongue, throat, hands, arms, feet, ankles, or lower legs

thirst

muscle weakness

restlessness

Tamoxifen may increase the risk that you will develop other cancers, including liver cancer. Talk to your doctor about this risk.

Tamoxifen may increase the risk that you will develop cataracts (clouding of the lens in the eye) that may need to be treated with surgery. Talk to your doctor about this risk.

Tamoxifen may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about storage and disposal of this medication?

Keep tamoxifen in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

uncontrollable shaking of a part of the body

unsteadiness

dizziness

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to tamoxifen.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking tamoxifen.

Do not let anyone else take your medication. Talk to your pharmacist if you have any questions about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

¶ This branded product is no longer on the market. Generic alternatives may be available.

Last Reviewed - 09/01/2010

American Society of Health-System Pharmacists, Inc. Disclaimer

AHFS ® Patient Medication Information. © Copyright, 2016. The American Society of Health-System Pharmacists, Inc. 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Lisinopril Dosage Guide With Precautions, Lisipril

Lisinopril Dosage

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 10 mg orally once a day; 5 mg orally once a day Maintenance dose: 20 to 40 mg orally once a day Maximum dose: 80 mg orally once a day

Comments : - The initial dose is 5 mg orally once a day in patients receiving a diuretic. - The 80 mg dose is used but does not appear to give greater effect. - If blood pressure is not controlled with lisinopril alone, a low dose of a diuretic may be added (e. g. hydrochlorothiazide, 12.5 mg). After the addition of a diuretic, it may be possible to reduce the dose of lisinopril.

Usual Adult Dose for Congestive Heart Failure

Initial dose: 2.5 to 5 mg orally once a day Maintenance dose: Dosage should be increased as tolerated Maximum dose: 40 mg orally once a day

Comments : - The diuretic dose may need to be adjusted to help minimize hypovolemia, which may contribute to hypotension. The appearance of hypotension after the initial dose of lisinopril does not preclude subsequent careful dose titration with the drug.

Usual Adult Dose for Myocardial Infarction

Initial dose: 5 mg orally (within 24 hours of the onset of acute myocardial infarction) Subsequent doses: 5 mg orally after 24 hours, then 10 mg orally after 48 hours. Maintenance dose: 10 mg orally once a day. Dosing should continue for at least 6 weeks.

Comments : - Therapy should be initiated at 2.5 mg in patients with a low systolic blood pressure (less than or equal to 120 mm Hg and greater than 100 mmHg) during the first 3 days after the infarct. If prolonged hypotension occurs (systolic blood pressure less than 90 mmHg for more than 1 hour) therapy should be withdrawn.

Uses: Reduction of mortality in acute myocardial infarction

Usual Adult Dose for Diabetic Nephropathy

Initial dose: 10 to 20 mg orally once a day Maintenance dose: 20 to 40 mg orally once a day Dosage may be titrated upward every 3 days

Comments : - Not an approved indication.

Usual Geriatric Dose for Hypertension

Initial dose: 2.5 to 5 mg orally once a day Maintenance dose: Dosages should be increased at 2.5 mg to 5 mg per day at 1 to 2 week intervals. Maximum dose: 40 mg orally once a day

Usual Pediatric Dose for Hypertension

Pediatric patients greater than or equal to 6 years of age : Initial dose: 0.07 mg/kg orally once a day (Maximum initial dose is 5 mg once a day) Maintenance dose: Dosage should be adjusted according to blood pressure response at 1 to 2 week intervals. Maximum dose: Doses above 0.61 mg/kg or greater than 40 mg have not been studied in pediatric patients

Comments : - This drug is not recommended in pediatric patients less than 6 years old or in pediatric patients with glomerular filtration rate less than 30 mL/min.

Renal Dose Adjustments

CrCl greater than 30 mL/min: No adjustment recommended CrCl 10 mL/min to less than or equal to 30 mL/min: Recommended initial dose is half of the usual recommended dose (i. e. hypertension, 5 mg; systolic heart failure, 2.5 mg, and acute MI, 2.5 mg. Up titrate as tolerated to a maximum of 40 mg daily) CrCl less than 10 mL/min or on hemodialysis: Recommended initial dose is 2.5 mg orally once a day

Liver Dose Adjustments

Patients who develop jaundice or marked elevations of hepatic enzymes should discontinue therapy and receive appropriate medical treatment.

Dose Adjustments

-The antihypertensive effect may diminish toward the end of the dosing interval regardless of the administered dose, but most commonly with a dose of 10 mg or less daily. This can be evaluated by measuring blood pressure just prior to dosing to determine whether satisfactory control is being maintained for 24 hours. If it is not, an increase in dose should be considered. If blood pressure is not adequately controlled with lisinopril alone, a diuretic may be added. After the addition of a diuretic, it may be possible to reduce the dose of lisinopril. - In all high risk patients, such as patients with ischemic heart or cerebrovascular disease, in whom excessive falls in blood pressure may lead to myocardial infarction or cerebrovascular accident the manufacturer advises treatment initiation at lower dosages. - Dosage adjustments in the elderly should be made with particular caution. - In patients who are currently being treated with a diuretic, symptomatic hypotension occasionally can occur following the initial dose. To reduce the likelihood of hypotension, the diuretic should, if possible, be discontinued 2 to 3 days prior to beginning therapy. Then, if blood pressure is not controlled with lisinopril alone, diuretic therapy should be resumed. If diuretic therapy cannot be discontinued, an initial dose of 5 mg should be used with careful medical supervision for several hours and until blood pressure has stabilized.

Precautions

US BOXED WARNINGS : - FETAL TOXICITY: Angiotensin converting enzyme (ACE) inhibitor use during pregnancy can cause morbidity and death to the developing fetus. When used during the second and third trimesters, ACE inhibitors have been associated with fetal and neonatal injury, including hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death. Oligohydramnios has also been reported, presumably resulting from decreased fetal renal function; oligohydramnios in this setting has been associated with fetal limb contractures, craniofacial deformation, and hypoplastic lung development. Exposure to ACE inhibitors during the first trimester of pregnancy has been associated with prematurity, intrauterine growth retardation, patent ductus arteriosus, other structural cardiac malformations, and neurological malformations. When pregnancy is detected, ACE inhibitors should be discontinued as soon as possible. If no alternative to ACE inhibitor therapy is available, patients should be made aware of the risks to their fetuses and the intra-amniotic environment should be evaluated by serial ultrasound examinations. If oligohydramnios develops, this drug should be discontinued unless it is considered lifesaving for the mother. Depending on the week of pregnancy, contraction stress testing, a nonstress test, or biophysical profiling may be appropriate. Oligohydramnios may not show until after the fetus has suffered irreversible injury.

Safety and efficacy have not been established in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

Dialysis

This drug can be removed by hemodialysis.

Other Comments

Administration advice : - Should be given as a single daily dose. - May be given with or without food. - In some patients with heart failure who have normal or low blood pressure, additional lowering of systemic blood pressure may occur with this drug. This effect is anticipated and is not usually a reason to discontinue treatment. If hypotension becomes symptomatic, a reduction of dose or discontinuation of may be necessary.

General : - This drug is indicated as adjunctive therapy with diuretics and digitalis for treating heart failure. - Following first time MI, all ACE inhibitors, at comparable appropriate dosages, appear to be equally effective for reducing mortality and recurrent MI rates. - Prior to therapy, patients at high risk of symptomatic hypotension such as patients with salt depletion with or without hyponatremia, hypovolemia or those receiving vigorous diuretic therapy should have these conditions corrected. Renal function and serum potassium should be monitored. - If it is not feasible to discontinue diuretic therapy prior to starting lisinopril, the patient should be closely monitored for several hours following the initial dose of this drug, and until the blood pressure has stabilized. The antihypertensive effects of lisinopril and diuretics used in combination are approximately additive. - Achievement of optimal blood pressure reduction may require 2 to 4 weeks of therapy. - Acute myocardial infarction: in addition to this drug, patients should receive, if appropriate, standard treatments, such as thrombolytics, aspirin, and a beta-blocker. - Antihypertensive effects of this drug are maintained during long-term therapy. Abrupt withdrawal has not been associated with a rapid increase in blood pressure, or a significant increase in blood pressure compared to pretreatment levels.

Patient advice : - This drug may be taken with or without food, but should be taken at the same time each day. - This drug may impair your ability to drive or operate machinery.

About Us, Nidelon

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Keramicke Noze Ceratio, Ceratio

Keramicke noze Ceratio

Take patrite k milovnikum domaci kuchyne, vareni je vas konicek a bavi vas vyhledavat a zkouset nove recepty? Objevili jste jiz keramicke noze . Ostry a kvalitni nuz je zakladem dobre fungujici kuchyne a kazda hospodynka nebo profesionalni kuchar povazuji sve noze za maly poklad. S keramicko - zirkoniovymi nozi vam priprava pokrmu pujde jeste lepe od ruky a vareni bude tou pravou zabavou.

Proc si keramicke noze nasly tak rychle uplatneni v ceskych domacnostech a odkud se vzaly? Sve tazeni modernimi kuchynemi zapocaly keramicke noze v Japonsku. Odtud se rychle presunuly do USA a i v CR jejich popularita rychle stoupa (jen nozu Ceratio se dosud v Ceske republice prodalo pres 200.000 ks ).

Cepel je vyrobena z oxidu zirkonia - materialu, ktery se zrodil v kosmickem prumyslu. Svou tvrdosti se blizi diamantu, je chemicky netecny (inertni) a neopotrebovava se. Cepel je prekvapive lehka, zustava po mnoho let ostra a ma nelepivy povrch. Vajicka, syr, rajcata a dalsi „problematicke potraviny“ budete s keramicko-zirkoniovym nozem krajet neuveritelne snadno. Keramicke ostri se navic snadno cisti a neabsorbuje chut ani zapach krajenych potravin.

Keramicko-zirkoniovy nuz jako prvni nuz na svete nenici vitaminy a enzymy obsazene v potravinach. Je to tedy jediny nuz, jehoz pouzivanim vlastne prospivate vasemu zdravi .

Tento web pouziva k poskytovani sluzeb, personalizaci reklam a analyze navstevnosti soubory cookie. Pouzivanim tohoto webu s tim souhlasite. V poradku Dalsi informace.

Nytol - Uses, Side Effects, Interactions, Nytol

Nytol

How does this medication work? What will it do for me?

Diphenhydramine belongs to a group of medications known as antihistamines. Antihistamines are used to treat symptoms caused by allergies, including itchy and watery eyes, sneezing, runny nose, and skin irritation. Diphenhydramine also causes drowsiness, and can be used by adults and children 12 years of age and older who occasionally have trouble sleeping (insomnia). The effects of diphenhydramine can last for up to 6 hours.

If you have trouble sleeping, do not take this medication for more than a few nights in a row. Talk to your doctor about other treatment options suitable for you if you have chronic (long-term) insomnia that persists for more than a few nights at a time.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

25 mg Each white, uncoated tablet, imprinted with an "N" on one side, contains diphenhydramine HCl 25 mg. Nonmedicinal ingredients: cornstarch, lactose, microcrystalline cellulose, silicon dioxide, and stearic acid.

50 mg Each blue, uncoated tablet, imprinted with an "N" on one side, contains diphenhydramine HCl 50 mg. Nonmedicinal ingredients: cornstarch, FD&C Blue No. 1 Aluminum Lake, lactose, microcrystalline cellulose, silicon dioxide, and stearic acid.

Caplets: Extra Strength Sleep Aid

Each blue, coated caplet, imprinted with "Nytol" on one side, contains diphenhydramine HCl 50 mg. Nonmedicinal ingredients: cornstarch, FD&C Blue No. 1 Aluminum Lake, lactose, microcrystalline cellulose, opadry light blue YS-1-4004, silicon dioxide, and stearic acid.

Capsules: Extra Strength Quickgels

Each clear, light yellow, soft gel capsule, imprinted with a white "N" on one side, contains diphenhydramine HCl 50 mg. Nonmedicinal ingredients: edible ink, gelatin, glycerin, polyethylene glycol, sorbitol, and water.

How should I use this medication?

The usual dose for adults and children 12 years of age and older to help with sleep is 25 mg to 50 mg taken by mouth at bedtime. Some people may only need to take 25 mg at bedtime if they are drowsy in the morning (e. g. they find it interferes with their daily activities) after taking the 50 mg dose.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor.

Store this medication at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e. g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Diphenhydramine should not be taken by anyone who:

is allergic to diphenhydramine or to any of the ingredients of the medication

has an enlarged prostate

has an obstructed bladder

has asthma or chronic lung disease

has certain stomach conditions (e. g. stenosing peptic ulcer or pyloroduodenal obstruction)

has glaucoma

has taken an antidepressant medication known as a MAO inhibitor (e. g. phenelzine, tranylcypromine, linezolid)

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

chest congestion

constipation

dizziness

drowsiness

dry mouth, nose, and throat

headache

inability to concentrate

increased perspiration

nausea or vomiting

restlessness

upset stomach

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

decreased muscle coordination

difficulty in passing urine

excitation (especially in children)

insomnia

muscle weakness

nervousness

rapid heart rate

vision problems

Stop taking the medication and seek immediate medical attention if any of the following occur:

chest tightness

skin rash or hives

wheezing

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Drowsiness/reduced alertness: Avoid driving or operating machinery until you have determined that you do not become drowsy during the day or experience impaired mental or physical abilities while taking this medication. Alcohol, sedatives, and pain medications can increase the side effects (e. g. drowsiness, inability to concentrate) of this medication. Do not undertake any activities that require alertness until you know how this medication affects you.

High blood pressure: People with high blood pressure should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Lung problems: People with lung problems (e. g. asthma, chronic pulmonary disease) should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Medical conditions: For some people, insomnia is caused by other medical conditions. If you have trouble sleeping for longer than 2 weeks, contact your doctor before taking this medication.

Thyroid disease: People with thyroid disease should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication may pass into breast milk. If you are a breast-feeding mother and are taking diphenhydramine, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: Diphenhydramine is not recommended to be used as a sleep aid for children under 12 years of age.

Seniors: Seniors may experience more side effects with this medication. Talk to your doctor before taking this medication.

What other drugs could interact with this medication?

There may be an interaction between diphenhydramine and any of the following:

alcohol

anticholinergic agents (e. g. atropine, scopolomine)

barbiturates (e. g. butalbital, phenobarbital)

benzodiazepines (e. g. alprazolam, diazepam, lorazepam)

chloral hydrate

narcotic analgesics (e. g. codeine, morphine, oxycodone)

neuroleptic medications (e. g. chlorpromazine, haloperidol, loxapine)

tricyclic antidepressants (e. g. amitriptyline, imipramine, nortriptyline)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,

change one of the medications to another,

change how you are taking one or both of the medications, or

leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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This site is not a substitute for medical advice. © 1996 - 2016

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Condition and disease information is written and reviewed by the MediResource Clinical Team. The contents of this site are for informational purposes only and are meant to be discussed with your physician or other qualified health care professional before being acted on. Never disregard any advice given to you by your doctor or other qualified health care professional. Always seek the advice of a physician or other licensed health care professional regarding any questions you have about your medical condition(s) and treatment(s).

This site is not a substitute for medical advice. © 1996 - 2016

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Triamterene And Hydrochlorothiazide - Fda Prescribing Information, Side Effects And Uses, Diurace

Triamterene and Hydrochlorothiazide

DESCRIPTION:

Triamterene and Hydrochlorothiazide tablets, USP, combines triamterene, a potassium-conserving diuretic, with the natriuretic agent, hydrochlorothiazide. Triamterene and Hydrochlorothiazide tablets are available in two strengths. Each Triamterene and Hydrochlorothiazide tablet, 75 mg/50 mg, contains triamterene, USP, 75 mg and hydrochlorothiazide, USP, 50 mg. Each triamterene and hydrochlorothaizide tablet, 37.5 mg/25 mg, contains triamterene, USP, 37.5 mg and hydrochlorothiazide, USP, 25 mg.

Both strengths of Triamterene and Hydrochlorothiazide tablets for oral administration contain the following inactive ingredients: anhydrous lactose, microcrystalline cellulose, polacrilin potassium, polyethylene glycol 8000, povidone, and magnesium stearate. Triamterene and Hydrochlorothiazide tablets, 37.5 mg/25 mg also contain FD&C Blue #2.

Triamterene is 2, 4, 7-triamino-6-phenylpteridine. Triamterene is practically insoluble in water, benzene, chloroform, ether and dilute alkali hydroxides. It is soluble in formic acid and sparingly soluble in methoxyethanol. Triamterene is very slightly soluble in acetic acid, alcohol and dilute mineral acids. Its molecular weight is 253.27. Its structural formula is:

Hydrochlorothiazide is 6-chloro-3, 4-dihydro-2 H -1, 2, 4-benzothiadiazine-7-sulfonamide 1, 1-dioxide. Hydrochlorothiazide is slightly soluble in water and freely soluble in sodium hydroxide solution, n-butylamine and dimethylformamide. It is sparingly soluble in methanol and insoluble in ether, chloroform and dilute mineral acids. Its molecular weight is 297.73. Its structural formula is:

CLINICAL PHARMACOLOGY:

Triamterene and Hydrochlorothiazide is a diuretic, antihypertensive drug product, principally due to its hydrochlorothiazide component; the triamterene component reduces the excessive potassium loss which may occur with hydrochlorothiazide use.

Hydrochlorothiazide:

Hydrochlorothiazide is a diuretic and antihypertensive agent. It blocks the renal tubular absorption of sodium and chloride ions. This natriuresis and diuresis is accompanied by a secondary loss of potassium and bicarbonate. Onset of hydrochlorothiazide’s diuretic effect occurs within 2 hours and the peak action takes place in 4 hours. Diuretic activity persists for approximately 6 to 12 hours.

The exact mechanism of hydrochlorothiazide’s antihypertensive action is not known, although it may relate to the excretion and redistribution of body sodium. Hydrochlorothiazide does not affect normal blood pressure. Following oral administration, peak hydrochlorothiazide plasma levels are attained in approximately 2 hours. It is excreted rapidly and unchanged in the urine.

Well-controlled studies have demonstrated that doses of hydrochlorothiazide as low as 25 mg given once daily are effective in treating hypertension, but the dose-response has not been clearly established.

Triamterene:

Triamterene is a potassium-conserving (antikaliuretic) diuretic with relatively weak natriuretic properties. It exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogen. With this action, triamterene increases sodium excretion and reduces the excessive loss of potassium and hydrogen associated with hydrochlorothiazide. Triamterene is not a competitive antagonist of the mineralocorticoids and its potassium-conserving effect is observed in patients with Addison’s disease, i. e. without aldosterone. Triamterene’s onset and duration of activity is similar to hydrochlorothiazide. No predictable antihypertensive effect has been demonstrated with triamterene.

Triamterene is rapidly absorbed following oral administration. Peak plasma levels are achieved within one hour after dosing. Triamterene is primarily metabolized to the sulfate conjugate of hydroxytriamterene. Both the plasma and urine levels of this metabolite greatly exceed triamterene levels.

The amount of triamterene added to 50 mg of hydrochlorothiazide in Triamterene and Hydrochlorothiazide tablets was determined from steady-state dose-response evaluations in which various doses of liquid preparations of triamterene were administered to hypertensive persons who developed hypokalemia with hydrochlorothiazide (50 mg given once daily). Single daily doses of 75 mg triamterene resulted in greater increases in serum potassium than lower doses (25 mg and 50 mg), while doses greater than 75 mg of triamterene resulted in no additional elevations in serum potassium levels. The amount of triamterene added to the 25 mg of hydrochlorothiazide in Triamterene and Hydrochlorothiazide tablets 37.5 mg/25 mg was also determined from steady-state dose-response evaluations in which various doses of liquid preparations of triamterene were administered to hypertensive persons who developed hypokalemia with hydrochlorothiazide (25 mg given once daily). Single daily doses of 37.5 mg triamterene resulted in greater increases in serum potassium than a lower dose (25 mg), while doses greater than 37.5 mg of triamterene, i. e. 75 mg and 100 mg, resulted in no additional elevations in serum potassium levels. The dose-response relationship of triamterene was also evaluated in patients rendered hypokalemic by hydrochlorothiazide given 25 mg twice daily. Triamterene given twice daily increased serum potassium levels in a dose-related fashion. However, the combination of Triamterene and Hydrochlorothiazide given twice daily also appeared to produce an increased frequency of elevation in serum BUN and creatinine levels. The largest increases in serum potassium, BUN and creatinine in this study were observed with 50 mg of triamterene given twice daily, the largest dose tested. Ordinarily, triamterene does not entirely compensate for the kaliuretic effect of hydrochlorothiazide and some patients may remain hypokalemic while receiving Triamterene and Hydrochlorothiazide. In some individuals, however, it may induce hyperkalemia (see WARNINGS ).

The Triamterene and Hydrochlorothiazide components of this product are well absorbed and are bioequivalent to liquid preparations of the individual components administered orally. Food does not influence the absorption of triamterene or hydrochlorothiazide from Triamterene and Hydrochlorothiazide tablets. The hydrochlorothiazide component of Triamterene and Hydrochlorothiazide tablets is bioequivalent to single entity hydrochlorothiazide tablet formulations.

INDICATIONS AND USAGE:

This fixed combination drug is not indicated for the initial therapy of edema or hypertension except in individuals in whom the development of hypokalemia cannot be risked.

Triamterene and Hydrochlorothiazide tablets are indicated for the treatment of hypertension or edema in patients who develop hypokalemia on hydrochlorothiazide alone.

Triamterene and Hydrochlorothiazide is also indicated for those patients who require a thiazide diuretic and in whom the development of hypokalemia cannot be risked (e. g. patients on concomitant digitalis preparations, or with a history of cardiac arrhythmias, etc.).

Triamterene and Hydrochlorothiazide may be used alone or in combination with other antihypertensive drugs such as beta-blockers. Since Triamterene and Hydrochlorothiazide may enhance the actions of these drugs, dosage adjustments may be necessary.

Usage in Pregnancy:

The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia in pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.

Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Thiazides are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy. Dependent edema in pregnancy, resulting from restriction of venous return by the expanded uterus, is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema, in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances, this edema may cause extreme discomfort which is not relieved by rest. In these cases, a short course of diuretics may provide relief and may be appropriate.

CONTRAINDICATIONS:

Hyperkalemia:

Triamterene and Hydrochlorothiazide should not be used in the presence of elevated serum potassium levels (greater than or equal to 5.5 mEq/liter). If hyperkalemia develops, this drug should be discontinued and a thiazide alone should be substituted.

Antikaliuretic Therapy or Potassium Supplementation:

Triamterene and Hydrochlorothiazide should not be given to patients receiving other potassium-conserving agents such as spironolactone, amiloride hydrochloride or other formulations containing triamterene. Concomitant potassium supplementation in the form of medication, potassium-containing salt substitute, or potassium-enriched diets should also not be used.

Impaired Renal Function:

Triamterene and Hydrochlorothiazide is contraindicated in patients with anuria, acute and chronic renal insufficiency or significant renal impairment.

Hypersensitivity:

Triamterene and Hydrochlorothiazide should not be used in patients who are hypersensitive to triamterene or hydrochlorothiazide or other sulfonamide-derived drugs.

WARNINGS:

Hyperkalemia: Abnormal elevation of serum potassium levels (greater than or equal to 5.5 mEq/liter) can occur with all potassium-conserving diuretic combinations, including Triamterene and Hydrochlorothiazide. Hyperkalemia is more likely to occur in patients with renal impairment, diabetes (even without evidence of renal impairment), or elderly or severely ill patients. Since uncorrected hyperkalemia may be fatal, serum potassium levels must be monitored at frequent intervals especially in patients first receiving Triamterene and Hydrochlorothiazide, when dosages are changed or with any illness that may influence renal function.

If hyperkalemia is suspected (warning signs include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia and shock), an electrocardiogram (ECG) should be obtained. However, it is important to monitor serum potassium levels because mild hyperkalemia may not be associated with ECG changes.

If hyperkalemia is present, Triamterene and Hydrochlorothiazide should be discontinued immediately and a thiazide alone should be substituted. If the serum potassium exceeds 6.5 mEq/liter, more vigorous therapy is required. The clinical situation dictates the procedures to be employed. These include the intravenous administration of calcium chloride solution, sodium bicarbonate solution and/or the oral or parenteral administration of glucose with a rapid-acting insulin preparation. Cationic exchange resins such as sodium polystyrene sulfonate may be orally or rectally administered. Persistent hyperkalemia may require dialysis.

The development of hyperkalemia associated with potassium-sparing diuretics is accentuated in the presence of renal impairment (see CONTRAINDICATIONS ). Patients with mild renal functional impairment should not receive this drug without frequent and continuing monitoring of serum electrolytes. Cumulative drug effects may be observed in patients with impaired renal function. The renal clearances of hydrochlorothiazide and the pharmacologically active metabolite of triamterene, the sulfate ester of hydroxytriamterene, have been shown to be reduced and the plasma levels increased following Triamterene and Hydrochlorothiazide administration to elderly patients and patients with impaired renal function.

Hyperkalemia has been reported in diabetic patients with the use of potassium-conserving agents even in the absence of apparent renal impairment. Accordingly, Triamterene and Hydrochlorothiazide should be avoided in diabetic patients. If it is employed, serum electrolytes must be frequently monitored.

Because of the potassium-sparing properties of angiotensin-converting enzyme (ACE) inhibitors, Triamterene and Hydrochlorothiazide should be used cautiously, if at all, with these agents (see PRECAUTIONS. Drug Interactions ).

Metabolic or Respiratory Acidosis:

Potassium-conserving therapy should also be avoided in severely ill patients in whom respiratory or metabolic acidosis may occur. Acidosis may be associated with rapid elevations in serum potassium levels. If Triamterene and Hydrochlorothiazide is employed, frequent evaluations of acid/base balance and serum electrolytes are necessary.

Acute Myopia and Secondary Angle-Closure Glaucoma:

Hydrochlorothiazide, a sulfonamide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation. Untreated acute angle-closure glaucoma can lead to permanent vision loss. The primary treatment is to discontinue hydrochlorothiazide as rapidly as possible. Prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy.

PRECAUTIONS:

General:

Electrolyte Imbalance and BUN Increases: Patients receiving Triamterene and Hydrochlorothiazide should be carefully monitored for fluid or electrolyte imbalances, i. e. hyponatremia, hypochloremic alkalosis, hypokalemia, and hypomagnesemia. Determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals. Serum and urine electrolyte determinations are especially important and should be frequently performed when the patient is vomiting or receiving parenteral fluids. Warning signs or symptoms of fluid and electrolyte imbalance include: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting.

Any chloride deficit during thiazide therapy is generally mild and usually does not require any specific treatment except under extraordinary circumstances (as in liver disease or renal disease). Dilutional hyponatremia may occur in edematous patients in hot weather; appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life threatening. In actual salt depletion, appropriate replacement is the therapy of choice.

Hypokalemia may develop with thiazide therapy, especially with brisk diuresis, when severe cirrhosis is present, or during concomitant use of corticosteroids, ACTH, amphotericin B, or after prolonged thiazide therapy. However, hypokalemia of this type is usually prevented by the triamterene component of Triamterene and Hydrochlorothiazide tablets.

Interference with adequate oral electrolyte intake will also contribute to hypokalemia. Hypokalemia can sensitize or exaggerate the response of the heart to the toxic effects of digitalis (e. g. increased ventricular irritability).

Triamterene and Hydrochlorothiazide may produce an elevated blood urea nitrogen level (BUN), creatinine level or both. This is probably not the result of renal toxicity but is secondary to a reversible reduction of the glomerular filtration rate or a depletion of the intravascular fluid volume. Elevations in BUN and creatinine levels may be more frequent in patients receiving divided dose diuretic therapy. Periodic BUN and creatinine determinations should be made especially in elderly patients, patients with suspected or confirmed hepatic disease, or renal insufficiencies. If azotemia increases, Triamterene and Hydrochlorothiazide should be discontinued.

Hepatic Coma: Triamterene and Hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

Renal Stones: Triamterene has been reported in renal stones in association with other calculus components. Triamterene and Hydrochlorothiazide should be used with caution in patients with histories of renal lithiasis.

Folic Acid Deficiency: Triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis in instances where folic acid stores are decreased. In such patients, periodic blood evaluations are recommended.

Hyperuricemia: Hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazide therapy.

Metabolic and Endocrine Effects: The thiazides may decrease serum PBI levels without signs of thyroid disturbance.

Calcium excretion is decreased by thiazides. Pathological changes in the parathyroid gland with hypercalcemia and hypophosphatemia have been observed in a few patients on prolonged thiazide therapy. The common complications of hyperparathyroidism such as renal lithiasis, bone resorption, and peptic ulceration have not been seen. Thiazides should be discontinued before carrying out tests for parathyroid function.

Insulin requirements in diabetic patients may be increased, decreased or unchanged. Diabetes mellitus which has been latent may become manifest during thiazide administration.

Hypersensitivity: Sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma.

Possible exacerbation or activation of systemic lupus erythematosus by thiazides has been reported.

Drug Interactions:

Thiazides may add to or potentiate the action of other antihypertensive drugs.

The thiazides may decrease arterial responsiveness to norepinephrine. This diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. Thiazides have also been shown to increase the responsiveness to tubocurarine.

Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. Refer to the package insert on lithium before use of such concomitant therapy.

Acute renal failure has been reported in a few patients receiving indomethacin and formulations containing Triamterene and Hydrochlorothiazide. Caution is therefore advised when administering non-steroidal anti-inflammatory agents with Triamterene and Hydrochlorothiazide.

Potassium-sparing agents should be used very cautiously, if at all, in conjunction with angiotensin-converting enzyme (ACE) inhibitors due to a greatly increased risk of hyperkalemia. Serum potassium should be monitored frequently.

Drug/Laboratory Test Interactions:

Triamterene and quinidine have similar fluorescence spectra; thus, Triamterene and Hydrochlorothiazide may interfere with the measurement of quinidine.

Carcinogenesis, Mutagenesis, Impairment of Fertility:

Carcinogenesis. Long-term studies with triamterene/hydrochlorothiazide combination have not been conducted.

Triamterene. In studies conducted under the auspices of the National Toxicology Program, groups of rats were fed diets containing 0, 150, 300 or 600 ppm triamterene and groups of mice were fed diets containing 0, 100, 200 or 400 ppm triamterene. Male and female rats exposed to the highest tested concentration received triamterene at about 25 and 30 mg/kg/day, respectively. Male and female mice exposed to the highest tested concentration received triamterene at about 45 and 60 mg/kg/day, respectively.

There was an increased incidence of hepatocellular neoplasia (primarily adenomas) in male and female mice at the highest dosage level. These doses represent 7.5 times and 10 times the MRHD of 300 mg/kg (or 6 mg/kg/day based on a 50 kg patient) for male and female mice, respectively when based on body-weight and 0.7 times and 0.9 times the MRHD when based on body-surface area. Although hepatocellular neoplasia (exclusively adenomas) in the rat study was limited to triamterene-exposed males, incidence was not dose-dependent and there was no statistically significant difference from control incidence at any dose level.

Hydrochlorothiazide. Two-year feeding studies in mice and rats, conducted under the auspices of the National Toxicology Program (NTP), treated mice and rats with doses of hydrochlorothiazide up to 600 and 100 mg/kg/day, respectively. On a body-weight basis, these doses are 600 times (in mice) and 100 times (in rats) the Maximum Recommended Human Dose (MRHD) for the hydrochlorothiazide component of Triamterene and Hydrochlorothiazide tablets (50 mg/day or 1 mg/kg/day based on a 50 kg patient). On the basis of body-surface area, these doses are 56 times (in mice) and 21 times (in rats) the MRHD. These studies uncovered no evidence of carcinogenic potential of hydrochlorothiazide in rats or female mice, but there was equivocal evidence of hepatocarcinogenicity in male mice.

Mutagenesis: Studies of the mutagenic potential of the Triamterene and Hydrochlorothiazide combination have not been performed.

Triamterene. Triamterene was not mutagenic in bacteria (S. typhimurium strains TA 98, TA 100, TA 1535 or TA 1537) with or without metabolic activation. It did not induce chromosomal aberrations in Chinese hamster ovary (CHO) cells in vitro with or without metabolic activation, but it did induce sister chromatid exchanges in CHO cells in vitro with and without metabolic activation.

Hydrochlorothiazide. Hydrochlorothiazide was not genotoxic in in vitro assays using strains TA 98, TA 100, TA 1535, TA 1537 and TA 1538 of Salmonella typhimurium (the Ames test), in the Chinese hamster ovary (CHO) test for chromosomal aberrations, or in in vivo assays using mouse germinal cell chromosomes, Chinese hamster bone marrow chromosomes, and the Drosophila sex-linked recessive lethal trait gene. Positive test results were obtained in the in vitro CHO sister chromatid exchange (clastogenicity) test, and in the mouse lymphoma cell (mutagenicity) assays, using concentrations of hydrochlorothiazide of 43 to 1300 mcg/mL. Positive test results were also obtained in the Aspergillus nidulans nondisjunction assay using an unspecified concentration of hydrochlorothiazide.

Impairment of Fertility. Studies of the effects of the triamterene/ hydrochlorothiazide combination, or of triamterene alone on animal reproductive function have not been conducted.

Hydrochlorothiazide: Hydrochlorothiazide had no adverse effects on the fertility of mice and rats of either sex in studies wherein these species were exposed, via their diet, to doses of up to 100 and 4 mg/kg/day, respectively, prior to mating and throughout gestation. Corresponding multiples of the MRHD are 100 (mice) and 4 (rats) on the basis of body-weight and 9.4 (mice) and 0.8 (rats) on the basis of body-surface area.

Pregnancy:

Teratogenic Effects: Category C: Animal reproduction studies to determine the potential for fetal harm by Triamterene and Hydrochlorothiazide tablets have not been conducted. Nevertheless, a One Generation Study in the rat approximated Triamterene and Hydrochlorothiazide’s composition by using a 1:1 ratio of triamterene to hydrochlorothiazide (30:30 mg/kg/day). There was no evidence of teratogenicity at those doses that were, on a body-weight basis, 15 and 30 times, respectively, the MRHD, and, on the basis of body-surface area, 3.1 and 6.2 times, respectively, the MRHD.

The safe use of Triamterene and Hydrochlorothiazide tablets in pregnancy has not been established since there are no adequate and well-controlled studies with Triamterene and Hydrochlorothiazide tablets in pregnant women. Triamterene and Hydrochlorothiazide tablets should be used during pregnancy only if the potential benefit justifies the risk to the fetus.

Triamterene: Reproduction studies have been performed in rats at doses as high as 20 times the Maximum Recommended Human Dose (MRHD) on the basis of body-weight, and 6 times the MRHD on the basis of body-surface area without evidence of harm to the fetus due to triamterene.

Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Hydrochlorothiazide: Hydrochlorothiazide was orally administered to pregnant mice and rats during respective periods of major organogenesis at doses up to 3000 and 1000 mg/kg/day, respectively. At these doses, which are multiples of the MRHD equal to 3000 for mice and 1000 for rats, based on body-weight, and equal to 282 for mice and 206 for rats, based on body-surface area, there was no evidence of harm to the fetus. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Nonteratogenic Effects: Thiazides and triamterene have been shown to cross the placental barrier and appear in cord blood. The use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus. These hazards include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and possibly other adverse reactions that have occurred in the adult.

Nursing Mothers:

Thiazides and triamterene in combination have not been studied in nursing mothers. Triamterene appears in animal milk and this may occur in humans. Thiazides are excreted in human breast milk. If use of the combination drug product is deemed essential, the patient should stop nursing.

Pediatric Use:

Safety and effectiveness in pediatric patients have not been established.

ADVERSE REACTIONS:

Side effects observed in association with the use of Triamterene and Hydrochlorothiazide tablets, other combination products containing triamterene/hydrochlorothiazide, and products containing triamterene or hydrochlorothiazide include the following:

Gastrointestinal: jaundice (intrahepatic cholestatic jaundice), pancreatitis, nausea, appetite disturbance, taste alteration, vomiting, diarrhea, constipation, anorexia, gastric irritation, cramping.

Central Nervous System: drowsiness and fatigue, insomnia, headache, dizziness, dry mouth, depression, anxiety, vertigo, restlessness, paresthesias.

Cardiovascular: tachycardia, shortness of breath and chest pain, orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics).

Renal: acute renal failure, acute interstitial nephritis, renal stones composed of triamterene in association with other calculus materials, urine discoloration.

Hematologic: leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia and megaloblastosis.

Ophthalmic: xanthopsia, transient blurred vision.

Hypersensitivity: anaphylaxis, photosensitivity, rash, urticaria, purpura, necrotizing angiitis (vasculitis, cutaneous vasculitis), fever, respiratory distress including pneumonitis.

Other: muscle cramps and weakness, decreased sexual performance and sialadenitis.

Whenever adverse reactions are moderate to severe, therapy should be reduced or withdrawn.

Altered Laboratory Findings:

Serum Electrolytes: hyperkalemia, hypokalemia, hyponatremia, hypomagnesemia, hypochloremia (see WARNINGS and PRECAUTIONS ).

Creatinine, Blood Urea Nitrogen: Reversible elevations in BUN and serum creatinine have been observed in hypertensive patients treated with Triamterene and Hydrochlorothiazide tablets.

Glucose: hyperglycemia, glycosuria and diabetes mellitus (see PRECAUTIONS ).

Serum Uric Acid, PBI and Calcium. (see PRECAUTIONS ).

Other: Elevated liver enzymes have been reported in patients receiving Triamterene and Hydrochlorothiazide tablets.

To report SUSPECTED ADVERSE REACTIONS, contact Actavis at 1-800-272-5525 or FDA at 1-800-FDA-1088 or www. fda. gov/medwatch.

OVERDOSAGE:

No specific data are available regarding Triamterene and Hydrochlorothiazide overdosage in humans and no specific antidote is available.

Fluid and electrolyte imbalances are the most important concern. Excessive doses of the triamterene component may elicit hyperkalemia, dehydration, nausea, vomiting and weakness and possibly hypotension. Overdosing with hydrochlorothiazide has been associated with hypokalemia, hypochloremia, hyponatremia, dehydration, lethargy (may progress to coma) and gastrointestinal irritation. Treatment is symptomatic and supportive. Therapy with Triamterene and Hydrochlorothiazide should be discontinued. Induce emesis or institute gastric lavage. Monitor serum electrolyte levels and fluid balance. Institute supportive measures as required to maintain hydration, electrolyte balance, respiratory, cardiovascular, and renal function.

DOSAGE AND ADMINISTRATION:

Note: 37.5 mg/25 mg= 37.5 mg triamterene and 25 mg hydrochlorothiazide

75 mg/50 mg= 75 mg triamterene and 50 mg hydrochlorothiazide

The usual dosage of Triamterene and Hydrochlorothiazide as a tablet is 37.5 mg/25 mg or 75 mg/50 mg daily, given as a single dose, with appropriate monitoring of serum potassium (see WARNINGS ). There is no experience with the use of more than 75 mg/50 mg daily of Triamterene and Hydrochlorothiazide. Clinical experience with the administration of 37.5 mg/25 mg of Triamterene and Hydrochlorothiazide twice daily in divided doses (rather than as a single dose) suggests an increased risk of electrolyte imbalance and renal dysfunction.

Patients receiving 50 mg of hydrochlorothiazide who become hypokalemic may be transferred to this 75 mg/50 mg product directly. Patients receiving 25 mg hydrochlorothiazide who become hypokalemic may be transferred to a 37.5 mg/25 mg product directly.

In patients requiring hydrochlorothiazide therapy and in whom hypokalemia cannot be risked, therapy may be initiated with 37.5 mg/25 mg of Triamterene and Hydrochlorothiazide. If an optimal blood pressure response is not obtained with 37.5 mg/25 mg Triamterene and Hydrochlorothiazide, the dose should be increased to 75 mg/50 mg daily as a single dose. If blood pressure still is not controlled, another antihypertensive agent may be added (see PRECAUTIONS. Drug Interactions ).

Clinical studies have shown that patients taking less bioavailable formulations of Triamterene and Hydrochlorothiazide in daily doses of 25 mg to 50 mg hydrochlorothiazide and 50 mg to 100 mg of triamterene may be safely changed to 37.5 mg/25 mg of Triamterene and Hydrochlorothiazide daily. All patients changed from less bioavailable formulations to Triamterene and Hydrochlorothiazide tablets should be monitored clinically and for serum potassium after the transfer.

HOW SUPPLIED:

Triamterene and Hydrochlorothiazide Tablets, USP, 75 mg/50 mg, are yellow, round, scored tablets, debossed with Watson 348 and are available in bottles of 30, 60, 90 COUNT.

Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Protect from light.

Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.

Slo-Phyllin Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Slo-Phyllin

Slo-Phyllin

GENERIC NAME(S): THEOPHYLLINE ANHYDROUS

Uses

Theophylline is used to treat lung diseases such as asthma and COPD (bronchitis. emphysema ). It must be used regularly to prevent wheezing and shortness of breath. This medication belongs to a class of drugs known as xanthines. It works in the airways by relaxing muscles, opening breathing passages, and decreasing the lungs' response to irritants. Controlling symptoms of breathing problems can decrease time lost from work or school.

This medication must be used regularly to be effective. It does not work right away and should not be used to relieve sudden breathing problems. If sudden shortness of breath occurs, use your quick-relief inhaler as prescribed.

How to use Slo-Phyllin

Take this medication by mouth as directed by your doctor, usually once or twice daily. Since different manufacturers have different ways to take this medication, ask your doctor or pharmacist about the best time(s) to take your brand of theophylline and if you should take the drug with or without food.

Do not crush or chew the capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

The dosage is based on your medical condition, response to treatment, age, weight. lab tests (theophylline blood levels), and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

Certain diets (such as high protein /low carbohydrate or high carbohydrate/low protein) may change the effect of theophylline. Tell your doctor if you have any major changes in your diet. Your doctor may need to adjust your dose.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking this medication even if you feel well. Do not increase your dose, take this drug more often, or stop taking it without first consulting your doctor.

Get medical help right away if your asthma symptoms worsen or if you are using your quick-relief inhaler more than usual or more often than prescribed.

Side Effects

Nausea /vomiting. stomach /abdominal pain. headache. trouble sleeping. diarrhea. irritability, restlessness, nervousness, shaking, or increased urination may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: nausea/vomiting that doesn't stop, fast/slow/irregular heartbeat. muscle cramps. fainting. confusion, dizziness .

Get medical help right away if you have any very serious side effects, including: seizures .

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using theophylline, tell your doctor or pharmacist if you are allergic to it; or to other xanthine drugs (such as aminophylline. oxtriphylline. caffeine ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach /intestinal ulcer, seizures, thyroid disease, heart problems (such as heart failure. irregular heartbeat), liver disease, high blood pressure .

If you get sick or have a fever while taking this medication, tell your doctor right away. The dose of your medicine may need to be adjusted.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially fast/irregular heartbeat, or trouble sleeping. Careful monitoring of side effects and drug blood levels is recommended.

Children may be more sensitive to the side effects of this drug. Careful monitoring of side effects and drug blood levels is recommended.

During pregnancy. this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Changes in your body during the last 3 months of pregnancy may affect the amount of this drug in your blood. Your doctor should carefully monitor the amount of drug in your blood, as well as any side effects, so that your dose may be changed if needed.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast - feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

A product that may interact with this drug is: riociguat.

Other medications can affect the removal of theophylline from your body, which may affect how theophylline works. Examples include cimetidine, disulfiram, fluvoxamine, interferon, mexiletine, propranolol, rifampin, drugs used to treat seizures (such as carbamazepine, phenytoin), St. John's wort, ticlopidine, among others.

Cigarette/marijuana smoking decreases blood levels of this medication. Tell your doctor if you smoke or if you have recently stopped smoking.

Caffeine and alcohol can increase the side effects of this medication. Avoid drinking large amounts of beverages containing alcohol or caffeine (such as coffee, tea, colas), eating large amounts of chocolate, or taking nonprescription products that contain caffeine.

Theophylline is very similar to aminophylline and oxtriphylline. Do not take medications containing aminophylline or oxtriphylline while using theophylline.

This medication may interfere with certain lab tests (such as blood sugar, cholesterol, uric acid, dipyridamole-thallium imaging tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: nausea/vomiting that doesn't stop, seizures, muscle cramps, fast/irregular heartbeat, mental/mood changes (such as agitation, confusion), vomit that looks like coffee grounds.

Notes

Do not share this medication with others.

Lab and/or medical tests (such as theophylline blood levels) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Missed Dose

If you miss a dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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ADHD Drug Side Effects

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Erio - S, Woodson Terrace, St, Erios

Itlaian Sausage Sandwich. On my second visit for lunch I tried the Italian Sausage sandwich. This was good quality Italian sausage with a nice spicy zing and best of all, they served on a soft Italian bread which made it very enjoyable to eat. The fries were perfectly cooked and nice and hot. I would definitely go back tor this!

-----11 May, 2012----- Ok, but could be better. I went in for the first time the other night to give the pizza a try. It's a nice little place with what appears to be a solid local following. The server took several minutes to finally getting around to taking my order for a dinner salad and small pizza. The dinner salad with house dressing was very good. The pizza probably belongs in the NY Style category: Thin crust, slightly crispy on the outer edge, very soft and floppy in the center. The tomato sauce seemed very basic, not much in the way of spice or flavor. There were plenty of topping ingredients (sausage, mushroom, onion) and they seemed fresh. The cheese was very stringy. When I attempted to cut a piece or pick it up and eat it, it quickly fell apart. I thought it might have been better if I had ordered it well done, as it did not seem all that hot when it was served (usually a pizza right out of the oven will burn the roof of your mouth!) I'm not crazy about the pizza, but I might go back to try one of the other dishes.

Itlaian Sausage Sandwich. On my second visit for lunch I tried the Italian Sausage sandwich. This was good quality Italian sausage with a nice spicy zing and best of all, they served on a soft Italian bread which made it very enjoyable to eat. The fries were perfectly cooked and nice and hot. I would definitely go back tor this!

-----11 May, 2012----- Ok, but could be better. I went in for the first time the other night to give the pizza a try. It's a nice little place with what appears to be a solid local following. The server took several minutes to finally getting around to taking my order for a dinner salad and small pizza. The dinner salad with house dressing was very good. The pizza probably belongs in the NY Style category: Thin crust, slightly crispy on the outer edge, very soft and floppy in the center. The tomato sauce seemed very basic, not much in the way of spice or flavor. There were plenty of topping ingredients (sausage, mushroom, onion) and. read more

El Epazote, Importante Hierba Culinaria Mexicana, Nipazol

El epazote

By Robin Grose. Comida Mexicana Expert

El epazote (nombre botanico: Dysphania ambrosioides o Teloxys ambrosioides ) es una hierba aromatica que se utiliza mucho en la cocina mexicana. Originaria de Americal Central, donde se cultiva para usos culinarios y medicinales, se ha exendido en forma silvestre (creciendo en lotes baldios y a al lado de los caminos) a gran parte del continente americano y hasta a Europa y Asia donde practicamente no se conocen sus usos.

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La planta

El epazote es una planta herbacea erecta, anual o perenne, segun el clima. La mata puede llegar, en condiciones favorables, a casi dos metros de altura y un metro de ancho. Sus hojas son de color verde oscuro y son largas, delgaldas, puntiagudas y dentadas. Las flores son pequenas y se da en forma de espiga, donde aparecen miles de pequenisimas semillas en el otono.

Usos medicinales del epazote

De la hoja y la flor del epazote se preparan infusiones (tes) para la eliminacion de parasitos intestinales en humanos y animales domesticos.

Tambien se ocupa para tratar colicos intestinales y otros males estomacales y hepaticos. En grandes cantidades, sin embargo, es toxico y ya no se acostumbra su empleo en la medicina moderna humana ni veterinaria por existir ya mejores y mas seguros remedios.

Usos culinarios del epazote

Esta hierba se utiliza casi exclusivamente en las cocinas mexicana y guatemalteca, donde se ocupan los tallos y las hojas frescas. Es un planta aroma y sabor fuertes (sin ser picante) y muy particular, por lo que muchas veces no gusta a la primera -- uno se tiene que ir acostumbrando a comerlo.

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Usa el epazote para darle sabor a los frijoles (especialmentes los frijoles negros), los caldos rusticos y los platos y sopas de hongos y de elote (granos de maiz). Es comun tambien incluir una ramita de epazote junto con el queso en el momento de preparar quesadillas.

De ser imposible conseguir epazote fresco, se puede utilizar en forma seca, aunque el sabor sera muy mas tenue.

La palabra epazote

La hierba se emplea de forma diaria en Oaxaca (al sur de Mexico) y en la Peninsula de Yucatan entre los pueblos de origen maya pero la palabra epazote deriva del nahuatl (lengua de de los antiguos aztecas) y significa sudor hedoroso . (Por cierto, el olor fuerte de la planta sirve para auyentar muchos tipos de insectos.) Se conoce tambien con los nombres pazote, ipasote, apazote, hierba hedionda, pazoli, pizate, y en el Peru, paico (vocablo que viene del idioma quechua). En ingles se llama wormseed, goosefoot . or Mexican tea .

Recetas con epazote

Saborea la hierba del epazote en los siguientes platillos mexicanos:

Flunil (Fluoxetine) Report For Patients Like You, Flunil

Flunil treatment report

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What is fluoxetine?

Fluoxetine is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Fluoxetine affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms.

Fluoxetine is used to treat major depressive disorder, bulimia nervosa (an eating disorder) obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder (PMDD).

Fluoxetine is sometimes used together with another medication called olanzapine (Zyprexa) to treat depression caused by bipolar disorder (manic depression). This combination is also used to treat depression after at least 2 other medications have been tried without successful treatment of symptoms.

Fluoxetine may also be used for purposes other than those listed in this medication guide.

Precautions

Do not use fluoxetine if you are using any of the following drugs:

pimozide (Orap);

thioridazine (Mellaril); or

an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam).

Serious and sometimes fatal reactions can occur when these medicines are taken with fluoxetine. You must wait at least 14 days after stopping an MAO inhibitor before you can take fluoxetine. You must wait 5 weeks after stopping fluoxetine before you can take thioridazine (Mellaril) or an MAOI.

Before taking fluoxetine, tell your doctor if you are allergic to any drugs, or if you have:

cirrhosis of the liver;

kidney disease;

diabetes;

seizures or epilepsy;

bipolar disorder (manic depression); or

a history of drug abuse or suicidal thoughts.

If you have any of these conditions, you may not be able to use fluoxetine, or you may need a dosage adjustment or special tests.

You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking fluoxetine, do not stop taking the medication without first talking to your doctor.

Fluoxetine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give fluoxetine to anyone younger than 18 years old without a doctor’s advice. Fluoxetine is the only antidepressant that is FDA-approved for use in children with depression.

Avoid drinking alcohol, which can increase some of the side effects of fluoxetine.

Fluoxetine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety). They can add to sleepiness caused by fluoxetine.

Instructions

Seek emergency medical attention if you think you have taken too much of this medication. Overdose may cause nausea, vomiting, fever, sleepiness, rapid or uneven heartbeat, confusion, fainting, seizures, or coma.

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose.

If you miss a dose of Prozac Weekly, take the missed dose as soon as you remember and take the next dose 7 days later. However, if it is almost time for the next regularly scheduled weekly dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

severe blistering, peeling, and red skin rash;

very stiff (rigid) muscles, high fever, sweating, fast or uneven heartbeats, tremors, overactive reflexes;

nausea, vomiting, diarrhea, loss of appetite, feeling unsteady, loss of coordination; or

headache, trouble concentrating, memory problems, weakness, confusion, hallucinations, fainting, seizure, shallow breathing or breathing that stops.

Less serious side effects may include:

cold symptoms such as stuffy nose, sneezing, sore throat;

drowsiness, dizziness, feeling nervous;

mild nausea, upset stomach, constipation;

increased appetite, weight changes;

sleep problems (insomnia);

decreased sex drive, impotence, or difficulty having an orgasm; or

dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Interactions

Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin and NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with fluoxetine may cause you to bruise or bleed easily.

Before taking fluoxetine, tell your doctor if you are using any of the following medicines:

alprazolam (Xanax);

clozapine (Clozaril, Fazaclo);

digitoxin (Crystodigin);

flecainide (Tambocor);

haloperidol (Haldol);

seizure medication such as phenytoin (Dilantin) or carbamazepine (Tegretol);

tryptophan (also called L-tryptophan);

vinblastine (Velban);

a blood thinner such as warfarin (Coumadin);

almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig); or

any other antidepressants such as amitriptyline (Elavil), escitalopram (Lexapro), imipramine (Tofranil), sertraline (Zoloft), and others.

This list is not complete and there may be other drugs that can interact with fluoxetine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

Prozac, Prozac Weekly, Rapiflux, Sarafem, fluoxetine, and Selfemra

Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

Last updated: September 19, 2016

What is the most important information I should know about fluoxetine?

Do not take fluoxetine together with pimozide (Orap), thioridazine (Mellaril), or a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking fluoxetine, do not stop taking the medication without first talking to your doctor.

Warning

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Megestron Long-Acting, Injectable Contraceptive, Megestron

Megestron: long-acting, injectable contraceptive. Guidelines for the health worker.

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Pangesic, Pangesic

Pangesic

Generic Name: Mefenamic Acid

* Description : Pangesic (Mefenamic Acid) is a non-steroidal with anti-inflammatory, analgesic and antipyretic activity. * Indications : Pangesic is indicated for : - The relief of mild to moderate pain including muscular, traumatic, dental pain, headache, post - operative and post-partum pain. - Dysmenorrhoea and menorrhagia. - For the relief of mild to moderate pain in rheumatoid arthritis and osteaorthritis. * Presentation• : Pangesic Capsules: Each capsule contains Mefenamic Acid BP, USP 250 mg. Blister packs of 20 & 100 capsules & hospital packs of different sizes are available. Pangesic-500 F/C Tablets: Each film coated tablet contains Mefenamic Acid BP, USP 500 mg. Blister packs of 20 & 100 tablets & hospital packs of different sizes are available Pangesic Suspension: Each 5 ml contains Mefenamic Acid BP, USP 50 mg. Bottles of 120 ml.

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Flutiderm, Flutiderm

Fluticasone

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Companies From India, Glucosamine-Indiabizclub, Oriforte

Companies From India - Glucosamine

Solitaire Pharmaceuticals Ahmedabad (India)

Manufacturer and supplier of various nutritional products. protein powder energy powder nutritional syrups lycopene with multivitamin syrup haematinic syrup multi vitamin mineral tonic b complex with l lysine syrup calcium supplement enzyme syrup appetizer syrupnutritional capsules multivitamins multiminerals capsules iron capsules pregabalin methylcobalamin capsulesnutritional tablets calcium tablets glucosamine chondroitin tablets ferrous ascorbate folic acid tablets

OTH Health New Delhi (India)

Ioth we source our health boosting vitamins and supplements only from the most valuable varieties across the world. our product list dietary supplements coenzyme q10 supplements ivitalise your body's best defense mechanism iresverayouth the powerful anti aging formula omega triplexpert the heart specialist pure primrose 1000 plush antioxidant benefits packed in a softgel eye wonder your way to healthy eyes imultiply the best multivitamin supplement healthy glow the richest source of vitamin e super omega triplexpert for superior heart protection cod liv vit e an incredible combination of cod liver oil and vitamin e tough and ton the most potent calcium vitamin b12 formula ioth idaily d the best possible source of vitamin d max joint triplexpert best ever formula for healthy pain free jointspharmaceutical f

Concord Drugs Limited Hyderabad (India)

We are manufacturers traders and service providers of finished pharmaceutical formulations such as injectables (small volume parenterals dry powder ) tissue bio adhesive tablets capsules and ophthalmic preparations and ready to fill pellets. albendazole tablets 400 mg levofloxacin tablets 750 mg ciprofloxacin tablets 250 mg ofloxacin tablets 400 mg divalproex sodium tablets 125 mg paracetamol tablets 500 mg paracetamol tablets 650 mg paracetamol diclofenac tablets 325mg 50mg paracetamol dicyclomine tablets 300mg 10mg paracetamol caffeine tablets 250mg 25mg paracetamol cpm tablets 325mg 2mg paracetamol phenylephrine cpm tablets 325mg 5mg 2mg paracetamol phenylephrine cetirizine tablets 325mg 10mg 5mg paracetamol nimesulide tablets 325 mg 100 mg paracetamol phenylephrine 300 mg 10mg cpm caffeine tablets 4mg 30mg paracetamol dicyclomine tablets 325mg 10mg paracetamol aceclofenac table

Anji Biosciences Hyderabad (India)

Manufacturer traders of fine specialty and pharmaceutical intermediates. our products range 4 acetylbenzeneboronic acid 3 acetyl benzonitrile 4 acetyl benzonitrile 5 acetyl 2 2 bithiophene 2 acetyl 5 bromothiophene 5 acetyl 2 (benzyloxy)benzoic acid ethyl ester 3 acetyl 2 5 dichlorothiophene 5 acetyl 2 hydroxybenzoic acid ethyl ester 3 acetylthiophene 2 aminoacetophenone hydrochloride 3 aminobenzeneboronic acid 4 aminobenzeneboronic acid 3 amino 2 cyclohexene 1 one 2 (2 aminoethyl) 1 methylpyrrolidine 5 aminoisoquinoline 2 aminomethylimidazole. Hcl 3 amino 4 methylthiophene 2 carboxylic acid met ester 3 amino 5 methylthiophene 2 carboxylic acid met. Ester 3 amino 5 phenylthiophene 2 carboxylic acid 3 aminothiophene 2 carboxylic acid methyl ester 3 aminophenylacetylene 4 aminophenylacetylene 1 4 benzene diboronic acid 2 benzimidazolepropionic acid 1

TRIMURTI DRUGS & PHARMACEUTICALS LIMITED. Hyderabad (India)

With automated processes of manufacturing and packing in place with our suppliers and meeting early to market environment and providing in time the time critical life saving drugs to sustain human life. manufacturer and trader ofservices distribution network for pharmaceutical products retail pharmacy marketing. products antibiotic/anti bacterial tricep 250/500 ciprofloxacin triflox 200mg ofloxacin troxi 150 mg roxithromycin td mox 250 mg capsules amoxycillin trispar 200mg sparfloxacin flextro norfloxacin metronidazole oriflox ofloxacin ornidizole sif 100mg tablets cefixime sif 200 mg tablets cefixime anti ulcer omidon cefixime 200mg. Tablets ulcizol pantoprozole tablets anti inflammatoryt analgesic oriforte diclo 50mg para 325mg. Chlorzoxazone 250mg. t flam diclofenac potassium 50mg. Pcm500mg. Magnesium trisilicate 100mg. painstar diclo50mg. Para500mg. trimosec tramodal h

Zeon-health Industries Navi Mumbai (India)

Welcome to the zeon health industries manufacturers exporters of standardized herbal extracts phytochemicals enzymes we are distinctly recognized amongst progressive manufacturers and exporters in various countries. our products liststandardised herbal extract ashwagandha gymnema sylvestre withania somnifera billberry extracts neem bitter triphala bhringraj bhui amla (phyllanthus niruri herb) reetha (sapindus fruit cortex) gokharu (tribulus terrestris ) guduchi (tinispora cordifolia root) guggul safad musli (asparagus racemous) kawach (mucuna prureins seed) daru haldi (berberis aristata root) muletti (glycyrrhiza glabra root ) calcium sennoside bp/usp amla (embelica officinalis) karela (momordica charantia) tulasi (ocimum sanctum herb) ginge

Chaitanya Biologicals Pvt. Ltd. Malkapur (India)

Manufacturers suppliers and exporters of nutraceuticals and pharmaceutical raw material like sodium ascorbate calcium aspartate soya isolate zinc ascorbate active pharmaceutical ingredients flavor enhancer bacteriological media ingredients cosmetic products aloe vera extract agriculture products animal feed supplements. nutraceuticals magnesium asparto ferric pyrophosphate calcium aspartate copper bis glycinate protein hydrolysate calcium caseinate sodium caseinate potassium caseinate soya isolate soya concentrate casein mineral protein complexes zinc ascorbate sodium ascorbateseasoning flavor enhancer hydrolyzed vegetable proteinactive pharmaceutical ingredients iron protein succinylate ferrous ascorbate calcium ascorbate ferrous glycine sulphate ferrous aminoate calcium fumarate calcium fumarate iron hydroxide polymaltose com

Roopa Industries Limited Hyderabad (India)

Manufacturers and suppliers of nutraceuticals bulk drugs and fine chemicals. our product glucosamine triphenyl phosphine bromine and its derivatives esomeprazole magnesium trihydrate tamsulosin

SSS BIOTIC PVT. LTD. Bhubaneswar (India)

We are manufacturers and exporters of nutraceuticals like glucosamine chitosan lutein lycopene etc spices and more than 100 different herbal products such as herbal powders extracts resins and raw herbs. We are also involved in research especially in the fields of nutrition biochemicals and seafood waste management. Our product list aloe aloe vera amla emblica officinalis arjuna terminalia arjuna ashwagandha withania somnifera asparagus asparagus racemosus bael aegle marmelos basil ocimum sanctum boswellia boswellia serrata bhumyamalaki phyllanthus amarus brahmi bacopa monnieri sweet flag acorus calamus coleus coleus forskohlii cowhage mucuna pruriens ellagic acid strawberry extract 4 hydroxyisoleucine fenugreek extract gokshura tribulus terrestris gurmar gymnema sylvestre guggul commiphora mukul guduchi tinospora cordifolia haritaki termin

Starr Healthcare Enterprises Inc. Hyderabad (India)

Starr healthcare enterprises inc. Manufacturer of herbal medicine products natural healthcare products customized packing herbal products and herbal product. Provides customized packing for natural healthcare product manufacturer of herbal medicine productsoffers a variety of herbal based products. Company and product information. our products are as follows herbalsfirst range of products prostatefirst prostatefirst super ovafirst ovafirst replace glafirst soyafirst black cohoshfirst greenteafirst hairfirst ginkgo biloba grape seed korean red ginseng romantic honeymoon milk thistle (silymarin) st. John s wort wild yam epa pure (omega 3) cod liver oil bee pollen dolomite shark cartilage super garlic adult fitness (geriatric formula) wheat germ oil vita optimus long life nopal memory aid arth aid ( glucosamine c

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Fusix Analysis - Strategic Advisers - International Ii Fund, Fusix

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Strategic Advisers ® International II Fund

Symbol: FUSIX

No Transaction Fee 1

Closed to new investors

This fund is only available to clients enrolled in Fidelity Portfolio Advisory Service ? This fund is only available to clients enrolled in Fidelity Portfolio Advisory Service ?

An interview with Portfolio Manager Wilfred Chilangwa

Reflecting challenging conditions in developed foreign markets, the fund posted a -11.70% return, but outpaced the -15.04% result of MSCI EAFE benchmark. It also beat its peer group average. The fund's relative outperformance was fueled by growth-focused managers and an aggregate tilt toward mid - and small-cap stocks.

My goal is to provide shareholders with diversified exposure across regions, sectors, market-capitalization ranges, investment styles and currencies within the broad foreign developed-markets equities universe. I work closely with our fund analysts to identify the managers I want to invest with and then build the portfolio from the bottom up. For this fund, our investment universe is limited to Fidelity mutual funds and affiliated sub-advisers. Using this group of underlying managers, I allocate assets based on my conviction in the manager's strategy, with an eye toward its risk-management role within the portfolio.

I review regional, sector, market-cap and style exposures to help ensure they are within my comfort zone relative to the MSCI EAFE Index. When I have a strong tactical view on a particular asset category, style or market, I will implement a modest tilt in the portfolio in an attempt to capitalize on the potential opportunity. I will sometimes use single-country funds to adjust the fund's aggregate exposure to a particular market, with the goal of keeping the fund's risk in line with that of the market.

As of period end, the fund's assets were allocated among 13 Fidelity mutual funds and one sub-advised strategy run by FIAM SM .

I added Fidelity Overseas Fund, and by period end it was among the fund's largest manager allocations. The manager of this fund employs a quality-oriented philosophy, looking for what he considers temporarily undervalued firms that he believes can consistently generate high returns on capital over a multiyear period. The manager seeks investment opportunities across the entire market-capitalization spectrum and had a sizable allocation to mid - and small-cap stocks.

I'm pleased to report that Fidelity Overseas was one of our top relative contributors for the period, led by strong security selection in information technology, financials, materials and consumer discretionary across Japan and Europe.

An out-of-benchmark stake in the United States provided a further boost to this manager's performance, as did underweighting Australia, which was one of the worst-performing markets for the period. Exposure to mid - and small-cap shares also proved advantageous, as stocks from these capitalization tiers outpaced larger-cap names.

Elsewhere, in July I reallocated all of the fund's assets that had been invested in FIAM's International Value strategy to managers in which I currently have greater conviction.

Fidelity International Discovery Fund and Fidelity International Capital Appreciation Fund were the two biggest relative contributors. Both of these managers use growth-oriented strategies, which worked well during a period when growth stocks significantly outperformed value stocks. Meaningful stakes in mid - and small-cap shares provided a further boost to these managers' results.

From a regional perspective, both managers benefited from stock picks in continental Europe and the United Kingdom. Fidelity International Discovery Fund also gained from selections in Japan, while Fidelity International Capital Appreciation Fund also was helped by holdings of U. S.-based multinational companies. On a sector basis, both managers did a nice job with picks in the consumer discretionary and financials sectors.

Similarly, Fidelity Diversified International Fund contributed due to its growth-focused strategy, as well as lighter-than-benchmark exposure to Australia. Sector-wise, picks in materials, financials and consumer staples added the most value.

The fund had no notable relative detractors. However, sub-adviser FIAM's International Value strategy nicked the fund's performance due to several disappointing picks in Japan and the United Kingdom.

In my view, global central banks had a disproportionate influence on market volatility during the past year. As central banks took steps to expand or fine-tune their monetary stimulus programs, market participants tried to reassess the likely efficacy of these efforts.

The European Central Bank (ECB) launched a massive bond-purchase program in January 2015. The ECB then ramped up its stimulus during the latter months of the period, including a larger-than-expected package of interest rate cuts, bond purchases and ultra-cheap loans in March 2016. The Bank of Japan stunned markets in January 2016 by setting the country's first negative interest rates in an attempt to propel Japan's economy out of deflation. While market participants are hopeful these measures will be effective at stimulating the economies in these regions, some worry that monetary policy alone won't be enough to bolster long-term growth and inflation.

Amid an environment of relatively weak economic expansion, the market has rewarded the stocks of companies exhibiting stable growth, leading to a prolonged period of growth outperforming value. As a result, growth-stock valuations appeared stretched as of period end. In a similar vein, small caps have outpaced large caps for some time. I discuss some of the reasons for this in the nearby callout box. Given this market backdrop, I have begun adjusting the portfolio to marginally rebalance the fund's aggregate exposure to growth versus value and small-caps versus large-caps. My goal is to keep the fund from becoming overextended in areas of the market that have performed well, while seeking to capitalize on areas that appear attractively valued. ■

Wilfred Chilangwa on the recent market environment:

"Outside the United States, small-cap stocks notably outpaced large-cap stocks during the past year. Small-caps within the MSCI EAFE index returned about -5%, versus -15% for the index overall. Small-cap shares of Japanese companies, with their flattish result, held up particularly well, as the recovery in Japan began to show signs of life and small-caps rebounded from low valuations.

"Within the MSCI EAFE, energy, materials and financials were the poorest-performing sectors in U. S.-dollar terms, pulled down by subpar results from many large-cap companies in those groups. Most of the global energy and commodity exporters to China are large-cap companies, and these firms struggled amid China's slower growth as well as the ongoing weakness in prices for oil and other commodities. In financials, large Australian banks were hampered partly by the country's economic ties with China, as well as by currency weakness.

"Large banks in Europe and Japan were hurt by their respective central-bank policies, particularly as rates in those regions fell to new lows, actually entering negative territory in Japan. Lower rates are weighing on bank profitability due to pressure on banks' net interest margins, or the difference between what banks pay for funds and what they can charge to lend those funds. Banks in the United Kingdom also faced difficulty due to their extensive customer networks in China and Asia generally."

Reflecting challenging conditions in developed foreign markets, the fund posted a -11.70% return for the 12 months ending February 29, 2016.

Despite its negative return, the fund outpaced the -15.04% result of its benchmark, the MSCI EAFE Index, led by growth-focused managers and an aggregate tilt toward better-performing mid - and small-cap stocks.

Fidelity ® International Discovery Fund and Fidelity ® International Capital Appreciation Fund contributed the most versus the benchmark, aided by their growth-oriented strategies and holdings of mid - and small-cap shares.

Portfolio Manager Wilfred Chilangwa added Fidelity Overseas Fund, and by period end it was among the fund's largest manager allocations. This manager employs more of a quality-oriented growth strategy and was another leading contributor.

The fund had no notable detractors, but the International Value strategy run by sub-adviser FIAM SM nicked the fund's performance.

International equities suffered a setback for the year ending February 29, 2016, held back by a collapse in commodity prices that affected resources-related sectors and geographies in particular. The non-U. S. developed-markets MSCI EAFE Index returned -15.04% for the 12-month period, hurt also by concerns about global economic growth. Stocks in developing markets fell further, with the MSCI Emerging Markets Index returning -23.13%. Commodity producers were pressured for much of the year, largely related to economic deceleration in China, the world's second-largest economy and a leading consumer of raw materials. Effects were exacerbated by U. S. dollar strength relative to global currencies, weighing on commodities priced in dollars and acutely affecting the equity returns of resources-related areas. Among regions within the MSCI EAFE Index, net energy consumer Japan (-10%) fared best; Asia Pacific ex Japan (-19%), worst. At the country level, only Denmark (+5%) and Israel (+3%) managed a gain, with several notching declines of greater than 20%. As for sectors, consumer staples (-2%) and telecommunication services (-6%) lost the least, whereas materials (-29%), financials (-22%) and energy (-21%) lost the most. Among emerging-markets countries, Hungary (+27%) proved the sole gainer. Meanwhile, Greece (-68%), Brazil (-40%), China (-29%) and India (-26%) headed the market's broad-based decline.

FISCAL PERFORMANCE SUMMARY

Periods ending FEBRUARY 29, 2016

1 Life of Fund (LOF) if performance is less than 10 years. Fund inception date: 03/08/2007.

2 This expense ratio is from the prospectus in effect as of the date shown above and generally is based on amounts incurred during that fiscal year.

Past performance is no guarantee of future results. Investment return and principal value of an investment will fluctuate; therefore, you may have a gain or loss when you sell your shares. Current performance may be higher or lower than the performance stated. Performance shown is that of the fund's Retail Class shares (if multiclass). You may own another share class of the fund with a different expense structure and, thus, have different returns. To learn more or to obtain the most recent month-end or other share-class performance, visit fidelity. com/performance. Total returns are historical and include change in share value and reinvestment of dividends and capital gains, if any. Cumulative total returns are reported as of the period indicated. Please see the last page(s) of this Q&A document for most-recent calendar-quarter performance.

Portfolio Manager Bios

Wilfred Chilangwa is a portfolio manager at Strategic Advisers, Inc. (SAI), a registered investment adviser and a Fidelity Investments company. Fidelity Investments is a leading provider of investment management, retirement planning, portfolio guidance, brokerage, benefits outsourcing and other financial products and services to more than 20 million individuals, institutions and financial intermediaries. In this role, Wilfred is responsible for managing Strategic Advisers International Fund, Strategic Advisers International II Fund, Strategic Advisers Emerging Markets Fund, Strategic Advisers International Multi-Manager Fund, Strategic Advisers Emerging Markets Fund of Funds, and the international subportfolio for Fidelity Portfolio Advisory Service® model portfolios. He also leads the Fidelity Charitable Gift Fund (CGF) investment efforts within SAI, where he is responsible for the oversight of all CGF investment pools. Prior to assuming his current position in 2006, Wilfred held various positions of increasing stature in SAI from 1997 to 2006. Previously, he was a senior fund analyst/international strategist from 2001 to 2006, and a senior fund analyst from 1997 to 2001. Before joining Fidelity in 1997, Wilfred worked as a senior research analyst and assistant vice president in new product development for global investment and asset administration at State Street Corporation from 1992 to 1997. He has been in the investments industry since 1992.Wilfred earned his bachelor of arts degree in physics and economics from Brandeis University and his master of arts degree in international economics and finance from Brandeis International Business School. He is also a Chartered Financial Analyst (CFA) charterholder.

Views of Strategic Advisers, Inc. are as of quarter end and are subject to change at any time based on market and other conditions. Data are unaudited. Information may not be representative of current or future holdings. This fund is available only to clients enrolled in Fidelity Portfolio Advisory Service ? .

Diversification/asset allocation does not ensure a profit or guarantee against loss.

You cannot invest directly in an index. The index performance includes the reinvestment of dividends and interest income. Securities indexes are not subject to fees and expenses typically associated with managed accounts or investment funds.

This presentation does not constitute an offer or solicitation to any person in any jurisdiction in which such offer or solicitation would be unlawful. Nothing contained herein constitutes investment, legal, tax, or other advice, nor is it to be relied on in making an investment or other decision. No assumptions should be made regarding the manner in which a client's account should or would be handled, as appropriate investment strategies will depend upon each client's investment objectives. None of the information contained herein takes into account the particular investment objectives, restrictions, tax or financial situation, or other needs of any specific client. Certain strategies discussed herein give rise to substantial risks and are not suitable for all investors. The information contained in this material is current only as of the date indicated, and may be superseded by subsequent market events or for other reasons. The information provided by third parties has been obtained from sources believed to be reliable, but Strategic Advisers, Inc. makes no representation as to its accuracy or completeness. Statements concerning financial market trends are based on current market conditions, which will fluctuate.

Past performance is no guarantee of future results.

Strategic Advisers is a registered service mark belonging to FMR LLC.

Fidelity Portfolio Advisory Service ? is a service of Strategic Advisers, Inc. a registered investment adviser and a Fidelity Investments company. This service provides discretionary money management for a fee.

Brokerage services provided by Fidelity Brokerage Services LLC. Custody and other services provided by National Financial Services LLC. Both are Fidelity Investments companies and members of NYSE and SIPC.

Fidelity Brokerage Services LLC, Member NYSE, SIPC, 900 Salem Street, Smithfield, RI 02917

The "Mutual Funds" area at the top of each page allows access to mutual fund holdings with individual and joint Fidelity non-retirement accounts. Individual stock positions, ETFs and 529 funds are not available through this view. For the full list of your holdings visit Portfolio Summary .

Mutual Funds are priced as of the previous business day's market close when the market is open. Mutual fund positions are priced as of the official market close (typically 4p. m.) and prices are generally available between 5 p. m. and 6p. m.

Watch a brief video to learn about using the new mutual fund library to evaluate funds

1. No Transaction Fee Fidelity funds are available without paying a trading fee to Fidelity or a sales load to the fund. However, the fund may charge a short-term trading or redemption fee to protect the interests of long-term shareholders of the fund. Shares are subject to the fund's management and operating expenses. See Expenses & Fees for more information.

Generally, data on Fidelity mutual funds is provided by FMR, LLC, Morningstar ratings and data on non-Fidelity mutual funds is provided by Morningstar, Inc. and data on non-mutual fund products is provided by the product's investment manager, trustee or issuer or the plan sponsor whose plan is offering the product to participants. Although Fidelity believes the data gathered from these third-party sources is reliable, it does not review such information and cannot warrant it to be accurate, complete or timely. Fidelity is not responsible for any damages or losses arising from any use of this third-party information.

Before investing, consider the investment objectives, risks, charges and expenses of the fund or annuity and its investment options. Contact Fidelity for a free prospectus and, if available, summary prospectus containing this information. Read it carefully.

Hapacol 500mg Extra (Paracetamol) - Rx Vietnam, Hapacol

Product Description

MÔ T? Thu?c gi?m dau có k?t h?p cafein

CÔNG TH?C Paracetamol. 500 mg Cafein. 65 mg Tá du?c v?a d?. 1 viên (Tinh b?t mì, màu erythrosin lake, PVP K30, b?t talc, magnesi stearat, aerosil, sodium starch glycolate, mùi dâu b?t) D?NG BÀO CH? Viên nén dài. QUY CÁCH DÓNG GÓI H?p 10 v? x 10 viên nén dài. TÍNH CH?T Hapacol extra k?t h?p paracetamol và cafein có tác d?ng gi?m nhanh các con dau, h? s?t v?i hi?u qu? r?t cao. Paracetamol có tác d?ng trung uong - ngo?i biên, có ho?t tính gi?m dau, h? nhi?t là do ?c ch? ho?t d?ng c?a men cyclooxygenase trong quá trình t?ng h?p prostaglandin - là ch?t gây s?t, viêm, dau trong co th?. Paracetamol h? nhi?t m?nh còn do tác d?ng lên vùng du?i d?i, do giãn m?ch và tang luu lu?ng máu ngo?i biên. Cafein có tác d?ng kích thích nh? h? th?n kinh trung uong, h? tr? gi?m dau và giúp cho ho?t d?ng c?a co du?c d? dàng. CH? D?NH Làm gi?m các con dau nh?c nhu nh?c d?u, dau rang, dau h?ng, dau b?ng kinh, dau nh?c co, gân, dau do ch?n thuong, dau do viêm kh?p, viêm xoang, dau nh?c do c?m l?nh, c?m cúm. H? s?t. CH?NG CH? D?NH M?n c?m v?i m?t trong các thành ph?n c?a thu?c. Suy ch?c nang gan. TH?N TR?NG Suy th?n n?ng. TUONG TÁC THU?C Paracetamol dùng cùng v?i thu?c ch?ng dông có th? làm tang tác d?ng c?a thu?c ch?ng dông máu. TÁC D?NG PH? Hi?m ph?n ?ng d? ?ng. Thông báo cho bác si nh?ng tác d?ng không mong mu?n g?p ph?i khi s? d?ng thu?c. CÁCH DÙNG Ngu?i l?n và tr? em trên 12 tu?i: u?ng 1-2 viên x 1 - 4 l?n / ngày. Không dùng quá 8 viên / ngày. Kho?ng cách t?i thi?u gi?a 2 l?n u?ng là 4 gi?. Ho?c theo ch? d?n c?a Th?y thu?c. D?c k? hu?ng d?n s? d?ng tru?c khi dùng. N?u c?n thêm thông tin, xin h?i ý ki?n bác si. H?N DÙNG 24 tháng k? t? ngày s?n xu?t. B?O QU?N Noi khô mát, tránh ánh sáng. TIÊU CHU?N TCCS.

DESCRIPTION Analgesic/Antipyretic COMPOSITION Paracetamol. 500 mg Caffeine. 65 mg Excipients. q.s. 1 tablet (Wheat starch, erythrosine lake color, PVP K30, talc powder, magnesium stearate, aerosil, sodium starch glycollate, strawberry flavor (powder)). DOSAGE FORM Tablets. PRESENTATION Box of 10 blisters x 10 tablets. ACTIONS Hapacol Extra is a combination of paracetamol and caffeine that is quickly, effectively analgesic and antipyretic. Paracetamol has a central-peripheral effect and analgesic, antipyretic properties due to an inhibition of cyclooxygenase action during the synthesis of prostaglandin - a substance causing fever, inflammations, and pains in the body. Paracetamol is a strong antipyretic due to action o­n hypothalamus, due to vasodilation and peripheral hypervolemia. Caffeine gently irritates o­n central nervous system, supports to relieve pains, and helps muscles act easily. INDICATIONS Relief of aches and pains e. g. headache, toothache, pharyngodynia, dysmenorrhea, myalgia, tenodynia, traumatic injuries, pains due to arthritis and sinusitis, aches and pains due to cold and flu. Antipyretic. CONTRAINDICATIONS Hypersensitivity to any components of Hapacol Extra. Impaired hepatic function. PRECAUTIONS Severe renal impairment. INTERACTIONS Concurrent use of paracetamol with anticoagulant may enhance the effect of anticoagulant. ADVERSE EFFECTS Allergic reactions have been rarely reported. Inform your physician about any adverse effects occur during the treatment. DOSAGE & ADMINISTRATION Adults and children > 12 years of age: oral dose of 1-2 tablets x 1 - 4 times daily. Do not take more than 8 tablets daily. The interval between oral doses should be at least 4 hours. Or as directed by the physician. Read the directions carefully before use. Consult the physician for more information. SHELF-LIFE 24 months from the manufacturing date. STORAGE CONDITIONS Store in cool, dry place; protected from light. SPECIFICATIONS Manufacturer's.

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Kop Carbabeta (Tegretol) Utan Recept, Carbabeta

Kopa Carbabeta (Tegretol) Natet Utan Recept

Carbabeta (Tegretol) Forklaring

Carbabeta fokus pa kan vara att avhjalpa garanterade komplicerade typer av beslag. Dessutom ar det anvands for att behandla neurala obehag fran motet till exempel trigeminusneuralgi samt diabetes skadade nerver, grupper bipolara support. Carbabeta ar faktiskt utfor genom att minska den faktiska verksamheten i samband med neurala som orsakar obehag och kramper. Det ar verkligen kramplosande.

Allmant titeln i samband med Carbabeta ar faktiskt karbamazepin.

Carbabeta kan ocksa kallas Karbamazepin, Tegrital.

Varumarke i samband med Carbabeta tenderar att vara Carbabeta, Carbabeta XR, Epitol, Equetro, Carbatrol.

Carbabeta (Tegretol) Dose

Carbabeta kommer in:

100mg lagre dos friktionsmaterial

200 mg Regular Dos friktionsmaterial

400mg Forbattrad Dos friktionsmaterial

Carbabeta kommer i piller (100 milligram, tva hundra milligram, fyra hundra mg), tuggtabletter, forlangda lanserings piller samt fordrojning, paus.

Vanligtvis inte slipa, tugga upp, eller ens knacka sjalva utdragna lanseringen piller.

Innan du tar vatske typ av Carbabeta du behover for att bli av med det.

Tugg piller borde bli biten fore intag.

terapi tillsammans med Carbabeta kunde producera ratt efter fyra veckor.

Nar det galler trigeminusneuralgi terapi

Den faktiska borjan dos i samband med Carbabeta ar faktiskt ett hundra milligram anvands tva ganger varje dag.

Nar det galler bipolar problem terapi

Den faktiska borjan dos i samband med Carbabeta ar faktiskt 200-400 milligram varje dag inom separerade doser.

Get Carbabeta samtidigt varje dag, utan eller med maltider.

Get Carbabeta piller genom munnen tillsammans med dricksvatten.

Forhindra grapefrukt samt grapefrukt juice.

Om du vill astadkomma basta resultaten brukar inte sluta med Carbabeta helt plotsligt.

Carbabeta (Tegretol) I brist forknippas med doserings

Vanligtvis far inte dubbel dos. Om du hoppar over dosen du behover for att bara den nar du kom ihag nar det galler din saknas. Nar det ar dags for dosering du behover bara pa din egen normal dosering rutin.

Carbabeta (Tegretol) Overdosering

Om du overdos Carbabeta och du ocksa undvika stora du behover kolla din lakare eller ens lakare omedelbart. Forknippas med Carbabeta overdosering: snabb hjartrytm, problem med ytlig samt inandning och utandning, illamaende eller krakningar, iver, muskelmassa ryckningar, kramper, trotthet, sluddrigt tal, skakningar, rendimiento, kasta upp, problem med peeing.

Carbabeta (Tegretol) Lagringsutrymme

Shoppa i rymdtemperaturer under trettio nivaer D (86 nivaer F) fran fukt och temperatur. Behall text ordentligt stangd. Skyddsatgarder igenom fukt. Starka nagon form av orord medicinering efter utgangen dagen. Behall placeras pa ett sakert satt ur vagen for barnen.

Carbabeta (Tegretol) Negativa effekter

Carbabeta erbjuder de negativa effekterna. Den mest typiska tenderar att vara:

trotthet friktionsmaterial

kombinerad eller ens muskelmassa obehag friktionsmaterial

ostadighet friktionsmaterial

kastar upp friktionsmaterial

missforstand friktionsmaterial

underben kramp friktionsmaterial

depressiva storningar friktionsmaterial

huvudvark friktionsmaterial

suddig syn friktionsmaterial

magen obehag friktionsmaterial

uttorkade munnen omradet friktionsmaterial

inflammerad sprakfriktionsmaterial

diarre, odem friktionsmaterial

bevarande friktions flytande material

illamaende eller krakningar friktionsmaterial

surr i orat friktionsmaterial

Mycket mindre typiska och allvarliga negativa effekter i hela anvander Carbabeta:

allergiska reaktion reaktioner (urtikaria, andas in och andas problem, allergi, samt utbrott) friktionsmaterial

varkande tonsiller friktionsmaterial

oregelbundna viss svaghet friktionsmaterial

problem med peeing friktionsmaterial

smartor i samband med hela kroppen friktionsmaterial

inflammation friktionsmaterial

roblems tillsammans med hunger friktionsmaterial

lagre temperatur friktionsmaterial

gulsot friktionsmaterial

Lerfargad barstolar friktionsmaterial

temperaturfriktionsmaterial

enkel blodning eller blamarken friktionsmaterial

Negativa effekter indikationer lita pa medicin du kanske anvander men dessutom forlita pa ditt valbefinnande villkor och en annan aspekter.

Carbabeta (Tegretol) Kontraindikationer

Vanligtvis inte far Carbabeta om du ar kanslig for att Carbabeta element.

Vanligtvis inte far Carbabeta bor du nagonsin upplevt en bra allergisk reaktion for att antidepressiva t ex desipramin (Norpramin), amitriptylin (Elavil), imipramin (Tofranil), klomipramin (Anafranil), doxepin (Sinequan). nortriptylin (Pamelor).

Vanligtvis inte far Carbabeta ifall du vantar, kommer att bli gravid och / eller ammar.

Vanligtvis inte far Carbabeta om du anvander denna typ av mediciner eftersom selegilin (sa eftersom Eldepryl, Emsam), tranylcypromin (sa eftersom Parnate), isokarboxazid (sa eftersom Marplan)), MAO-hammare (fenelzin (t. ex. pa grund Nardil), vila lakemedel.

Var forsiktig om du anvander nagon form av lakare ordinerats eller receptfria lakemedel, naturlig beredning, eller ens komplettera.

Var forsiktig langs med Carbabeta om du drabbas av och har en kort historia i samband med magert kott eller till och med hjartproblem, psykiska sjukdomar. laupus, glaukom, benvavnad marg minskningar

Seniorer bor vara forsiktig tillsammans med Carbabeta.

Var forsiktig tillsammans med solsken. Forsok att skydda huden.

Om du stoter pa somnighet samt trotthet medan du anvander Carbabeta maste du forhindra nagon form av atgarder till exempel reser eller aven arbetsutrustning.

Forhindra alkoholhaltiga drycker medan du anvander Carbabeta.

Det kan vara skadligt att forhindra Carbabeta anvander helt plotsligt.

Carbabeta (Tegretol) Vanliga fragor

Queen: Vad exakt ar Carbabeta?

Det ar verkligen anticonvulsant. A

Queen: Vad exakt ar Carbabeta fokusera pa?

Carbabeta fokuserar pa kan vara att avhjalpa garanterade komplicerade typer av beslag. Dessutom ar det anvands for att behandla neurala obehag fran motet till exempel trigeminusneuralgi samt diabetes skadade nerver, bipolar stod groups. A

Queen: Sa hur exakt gor Carbabeta funktion?

Carbabeta ar faktiskt utfor genom att minska den faktiska verksamheten i samband med neurala som orsakar obehag samt seizures. A

Queen: Exakt vad ska jag fag situationen i samband med dosering saknas?

I handelse av dosen saknar du behover for att p-piller sa fort som mojligt. Vanligtvis blir inte dubbel dos. Och nar det verkligen ar mest lyckosamma tid for dos du behover bara pa din egen vanliga rutin i samband med Carbabeta using. A

Queen: Maste vi verkligen anvander Carbabeta?

Vanligtvis inte far general Topamax om du ar kanslig for att General Topamax element. Vanligtvis inte far general Topamax om du vantar, kommer att bli gravid och / eller ammar feeding. A

Queen: May Carbabeta utlosa allergisk attack?

Carbabeta allergisk reaktion svaren tenderar att vara eccema, andas in och andas problem, allergi, liksom eruption. A

Kop Carbabeta (Tegretol) natet, kop Carbabeta (Tegretol) Utan Recept, kop Carbabeta (Tegretol) utan recept, kop Carbabeta (Tegretol) billig, kopa Carbabeta (Tegretol) utan recept, kop Carbabeta (Tegretol) fran Kanada, kop Carbabeta (Tegretol) Kanada, kopa Carbabeta (Tegretol) natet, kopa Carbabeta (Tegretol) natet utan recept, kopa Carbabeta (Tegretol) utan recept, Carbabeta (Tegretol) orala piller

Sok

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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Birth Control Continuously Taking The Pill, Femiane, Taking The Pills, Femiane

Birth Control / Continuously Taking the Pill

Question I'm 17yrs old and have been on the pill for about 6 months. After doing an ultrasound and blood tests that came back clear, my doctor placed me on the pill because I had horrible cramps, vomiting, and diarrhea whenever my period came around. I would have to miss school and spend two or three days laying in bed.

She placed me on Femiane, which is used for 21 days and then you break for 7 (which is when your period is supposed to come). The little pamphlet that comes with the package says that you can start a new set of pills right after you finish the first 21 pills if you want to skip your period.

Although, my periods have been much improved since going on the pill. they are still painful and affect how I do in school.

I'm wondering if there is any danger in continuing to take the pill without breaking for months at a time. I have already skipped two periods (I'm in my 3rd set without breaking).

I would like to take it for as long as possible, and avoid as many periods as possible. Are there any side effects that I should know about? Is this even a wise/safe thing to do?

Thanks so much in advance!

Answer Hi Jessa,

It's fine to keep taking the active pills and trying to avoid periods. Usually it only works for so long, and then you may get some bleeding. If it's slight, you can ignore it. If it's more, then you can stop the pill for 4-7 days, let your period come, and then restart the active pills. Then keep taking the pills as long as you can. It's not harmful to avoid periods in this way, and if you're lucky, you may have very few periods in a year.

Ventolin Hfa Inhalation Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Venetlin

Ventolin HFA inhalation

GENERIC NAME(S): ALBUTEROL SULFATE

Uses

Albuterol (also known as salbutamol) is used to prevent and treat wheezing and shortness of breath caused by breathing problems (such as asthma. chronic obstructive pulmonary disease ). It is also used to prevent asthma brought on by exercise. It is a quick-relief drug. Albuterol belongs to a class of drugs known as bronchodilators. It works in the airways by opening breathing passages and relaxing muscles. Controlling symptoms of breathing problems can decrease time lost from work or school.

How to use Ventolin HFA inhalation

Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. Follow the illustrated directions for the proper use of this medication and proper cleaning of the mouthpiece. If you have any questions, consult your doctor or pharmacist.

Shake the canister well before using. Follow the instructions for test sprays in the air if you are using a canister for the first time or if you have not used it for 2 weeks or more, or if the inhaler has been dropped. A fine mist is a sign that the inhaler is working properly. Avoid spraying the medication in your eyes .

Inhale this medication by mouth as directed by your doctor, usually every 4 to 6 hours as needed. Dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often than prescribed without your doctor's approval. Using too much of this medication will increase your risk of serious (possibly fatal) side effects.

If you are using this medication to prevent asthma brought on by exercise. inhale as directed by your doctor, usually 2 puffs 15 to 30 minutes before exercise.

It is recommended that you use a spacer device with this medication. Ask your doctor or pharmacist for more information.

If two inhalations are prescribed, wait at least 1 minute between them.

If you are using other inhalers at the same time, wait at least 1 minute between the use of each medication.

Always have this quick-relief inhaler with you. Keep track of the number of inhalations you use, and discard the inhaler after you have used the labeled number of inhalations on the product package. Also count test sprays used to prime the inhaler.

Learn which of your inhalers you should use every day (controller drugs) and which you should use if your breathing suddenly worsens (quick-relief drugs). Ask your doctor ahead of time what you should do if you have new or worsening cough or shortness of breath, wheezing. increased sputum, worsening peak flow meter readings, waking up at night with trouble breathing, if you use your quick-relief inhaler more often (more than 2 days a week), or if your quick-relief inhaler does not seem to be working well. Learn when you can treat sudden breathing problems by yourself and when you must get medical help right away.

Tell your doctor if your symptoms do not improve or if they worsen.

Side Effects

Nervousness, shaking (tremor), headache. mouth /throat dryness or irritation, changes in taste, cough. nausea or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: fast/pounding heartbeat.

Get medical help right away if you have any rare but very serious side effects, including: chest pain. irregular heartbeat. rapid breathing, confusion.

Rarely, this medication has caused severe (rarely fatal), sudden worsening of breathing problems/asthma (paradoxical bronchospasm). If you experience sudden wheezing, get medical help right away.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using albuterol, tell your doctor or pharmacist if you are allergic to it; or if you have had a serious reaction to similar drugs (such as levalbuterol. metaproterenol. terbutaline ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as irregular heartbeat, angina. heart attack ), high blood pressure. seizure .

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy. this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast - feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Albuterol is very similar to levalbuterol. Do not use medications containing levalbuterol while using albuterol.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fast/pounding/irregular heartbeat, severe shaking (tremors), seizures.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as a lung /breathing test, blood pressure) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Avoid allergens/irritants such as smoke, pollen. pet dander, dust, or molds that may worsen breathing problems.

Learn to use a peak flow meter, use it daily, and promptly report worsening breathing problems (such as readings in the yellow/red range, increased use of quick-relief inhalers).

Ask your doctor or pharmacist whether you should have an annual flu shot.

Missed Dose

If you are using this medication on a prescribed schedule and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. It is best to store the inhaler with the mouthpiece down. Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist.

Do not puncture the canister or expose it to high heat or open flame. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Kalnex, Kalnex

Kalnex, Obat untuk Menghentikan Kondisi Perdarahan

Kalnex termasuk golongan obat tranexamic acid. Tranexamic acid digunakan untuk membantu menghentikan kondisi perdarahan. Tranexamic acid merupakan agen antifibrinolytic. Golongan obat ini bekerja dengan menghalangi pemecahan bekuan darah, sehingga mencegah pendarahan. Obat ini hanya tersedia dengan resep dokter.

Obat ini tersedia dalam bentuk sediaan berikut: 1. Tablet 2. Kapsul 3. Infus

Kandungan Tranexamic acid

1. Fibrinolisis lokal seperti: a. Epistaksis b. Prostatectomy c. Cervical conisation

2. Herediter angioneurotic edema 3. Perdarahan abnormal setelah operasi 4. Perdarahan setelah pencabutan gigi pada pasien dengan riwayat hemofilia.

1. Gagal ginjal berat 2. Pembekuan intravaskular aktif 3. Penyakit tromboemboli 4. Gangguan penglihatan warna 5. Perdarahan subarachnoid

1. Kapsul: 1-2 kapsul 3-4 kali sehari. 2. Tablet: 1 tablet 3-4 kali sehari 3. Infus: a. 250 mg 1-2 amp/hari IV atau IM dosis terbagi 1-2 atau 2-10 amp dengan infus. b. 500 mg amp 2,5-5 mL IV atau IM setiap hari dalam 1-2 dosis. c. Selama atau setelah operasi: 5-25 mL dengan infus IV jika perlu.

Segera periksa ke dokter, jika terjadi salah satu efek samping berikut ini: 1. Kulit pucat 2. Masalah pada pernapasan 3. Perdarahan atau memar yang tidak biasa 4. Kelelahan atau kelemahan

Sumber: MayoClinic, Drugs. com

Buy Woman S Health - Dropflam (Brand Name Diclofenac) Online - Order Diclofenac - Purchase Woman S H

Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis. Diclofenac may also be used for purposes other than those listed in this medication guide.

Use Diclofenac as directed by your doctor.

Take Diclofenac by mouth with or without food. Ask your health care provider any questions you may have about how to use Diclofenac.

Drug Class and Mechanism

Diclofenac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

If you miss a dose of Diclofenac, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Store Diclofenac at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do not use Diclofenac if:

you are allergic to any ingredient in Diclofenac; you have had a severe allergic reaction (e. g. severe rash, hives, breathing difficulties, dizziness) to another NSAID (e. g. ibuprofen, naproxen, celecoxib) or aspirin. Contact your doctor or health care provider right away if any of these apply to you.

Important : Diclofenac may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Before you start any new medicine, check the label to see if it has Dropflam or another nonsteroidal anti-inflammatory drug (NSAID) medicine in it too. If it does or if you are not sure, check with your doctor or pharmacist. Diclofenac should not be used in children; safety and effectiveness in children have not been confirmed. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breast-feed while using Diclofenac.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

burning or stinging; discharge; eye redness, irritation, or itching. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred or distorted vision; eye infection; eyelid swelling or redness; sensitivity to glare or light.

Diclofenac is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

Design, Synthesis, Mechanisms Of Action, And Toxicity Of Novel 20(S)-Sulfonylamidine Derivatives Of

Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents

Mei Juan Wang ; Ying Qian Liu ; Ling Chu Chang ; Chih Ya Wang ; Yong Long Zhao ; Xiao Bo Zhao ; Keduo Qian ; Xiang Nan ; Liu Yang ; Xiao Ming Yang ; Hsin Yi Hung ; Jai Sing Yang ; Daih Huang Kuo ; Masuo Goto ; Susan L. Morris-Natschke ; Shiow Lin Pan ; Che Ming Teng ; Sheng Chu Kuo ; Tian Shung Wu ; Yang Chang Wu ; Kuo Hsiung Lee

Abstract

Twelve novel 20-sulfonylamidine derivatives (9a-9l) of camptothecin (1) were synthesized via a Cu-catalyzed three-component reaction. They showed similar or superior cytotoxicity compared with that of irinotecan (3) against A-549, DU-145, KB, and multidrug-resistant (MDR) KBvin tumor cell lines. Compound 9a demonstrated better cytotoxicity against MDR cells compared with that of 1 and 3. Mechanistically, 9a induced significant DNA damage by selectively inhibiting Topoisomerase (Topo) I and activating the ATM/Chk related DNA damage-response pathway. In xenograft models, 9a demonstrated significant activity without overt adverse effects at 5 and 10 mg/kg, comparable to 3 at 100 mg/kg. Notably, 9a at 300 mg/kg (i. p.) showed no overt toxicity in contrast to 1 (LD 50 56.2 mg/kg, i. p.) and 3 (LD 50 177.5 mg/kg, i. p.). Intact 9a inhibited Topo I activity in a cell-free assay in a manner similar to that of 1, confirming that 9a is a new class of Topo I inhibitor. 20-Sulfonylamidine 1-derivative 9a merits development as an anticancer clinical trial candidate. © 2014 American Chemical Society.

Astelin Side Effects In Detail, Astalin

Astelin Side Effects

Note: This page contains information about the side effects of azelastine nasal. Some of the dosage forms included on this document may not apply to the brand name Astelin.

In Summary

Common side effects of Astelin include: drowsiness, dysgeusia, and bitter taste. Other side effects include: epistaxis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to azelastine nasal: nasal spray

In addition to its needed effects, some unwanted effects may be caused by azelastine nasal (the active ingredient contained in Astelin). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking azelastine nasal:

Rare

Blood in the urine

blurred vision or other change in vision

cough

eye pain

eye redness

hives, itching, or skin rash

rapid heartbeat

sores in the mouth or on the lips

tightness in the chest

troubled breathing

Minor Side Effects

Some of the side effects that can occur with azelastine nasal may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

Bitter taste in the mouth

drowsiness or sleepiness

Less common:

Bloody mucus or unexplained nosebleeds

burning inside the nose

dizziness

dryness of the mouth

headache

muscle aches or pain

nausea

sore throat

sudden outbursts of sneezing

unusual tiredness or weakness

weight gain

For Healthcare Professionals

Applies to azelastine nasal: nasal spray

General

The most commonly reported adverse reactions were headache, bitter taste, sinusitis, and epistaxis. [Ref ]

Respiratory

Common (1% to 10%): Epistaxis, nasal discomfort, upper respiratory infection, sneezing, nasal mucosal ulceration, sinusitis Postmarketing reports: Nasal burning, throat irritation, dyspnea, paroxysmal sneezing [Ref ]

Hypersensitivity

Postmarketing reports: Anaphylactoid reaction [Ref ]

Local

Postmarketing reports: Application site irritation [Ref ]

Nervous system

Very common (10% or more): Bitter taste (10%) Common (1% to 10%): Headache, somnolence, dysgeusia Postmarketing reports: Sweet taste, confusion, dizziness, nervousness, paraesthesia, parosmia, involuntary muscle contractions, disturbance or loss of sense of smell and/or taste [Ref ]

Cardiovascular

Postmarketing reports: Atrial fibrillation, chest pain, hypertension, palpitations, tachycardia [Ref ]

Dermatologic

Very rare (less than 0.01%): Urticaria, pruritus, rash [Ref ]

Gastrointestinal

Postmarketing reports: Abdominal pain, nausea [Ref ]

Other

Common (1% to 10%): Fatigue Postmarketing reports: Facial edema, tolerance [Ref ]

Ocular

Postmarketing reports: Blurred vision, xerophthalmia [Ref ]

Genitourinary

Postmarketing reports: Urinary retention [Ref ]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Astepro (azelastine nasal)." Meda Pharmaceuticals, Somerset, NJ.

3. "Product Information. Astelin (azelastine)." Carter Products, Cranbury, NJ.

Not all side effects for Astelin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .

More about Astelin (azelastine nasal)

Consumer resources

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. The information is not a substitute for the knowledge and judgement of a healthcare professional. Always consult with your doctor, nurse, or pharmacist before taking medication.

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Great Planes Avistar 30cc Almost Ready-To-Fly 30cc, Avistar

This giant keeps growing with you.

Add the Avistar 30cc/EP to your hangar today for giant-scale sport training — and it will continue giving you new opportunities to try optional flaps, floats, and even sailplane towing. Easy to fly for less experienced pilots, yet with the power and maneuverability to satisfy seasoned fliers, it’s the perfect introduction to gasoline engines or large electric power.

Top-quality balsa/ply construction for strength and durability

Two-piece wing with pre-hinged control surfaces

Aerobatic but forgiving for new sport fliers

The Avistar 30cc/EP’s realistic looks are highlighted by a fiberglass cowl and wheel pants; clear side windows and windshield; and a removable, black ABS cockpit floor. Decals are included for adding an N-number, cargo door and landing lights to the preapplied covering scheme.

A spacious fuselage allows ample room for installation of your radio gear and power system components. A magnetically secured hatch makes LiPo changes fast and easy.

With gasoline power, the Avistar 30cc/EP is economical to fly and needs minimal maintenance.

With a brushless electric motor system, you’ll reduce noise and enjoy “instant” power — ideal if you plan to add floats and fly off water.

Factory-hinged flaps are built into the wing. They can easily be made operational by cutting the flaps free from the ailerons and adding the required servos. With functional flaps, your model will be capable of slower takeoff and “light as a feather” landing speeds.

GPMA1675 Wingspan: 90.5 in (2300 mm) Wing Area: 1448 in2 (93.4 dm²) Weight: 16.5-17.5 lb (7.5-7.9 kg) Length: 77.25 in (1962 mm) Wing Loading: 26-28 oz/ft² (79-85 g/dm²) Requires: 4-6 channel radio with minimum 5 high-torque servos (additional standard servo for throttle when using gas power); 30-35 cc gas engine OR 63-62-250kV electric motor, 60A ESC and two 4S 14.8V 5000mAh or two 5S 18.5V 5000mAh LiPo batteries and charger

Options available for the Avistar 30cc/EP.

The Avistar 30cc/EP includes taildragger landing gear. If you prefer a tricycle setup, use the optional Nose Gear Conversion Set (GPMA4568) and Nose Gear Wheel Pant (GPMA4561). With either configuration, ground handling is solid and predictable.

For thrilling water takeoffs, replace the landing gear with Great Planes’ optional Float Kit (GPMA1676). Twin water rudders provide precise taxiing control and “kick up” when striking obstacles to avoid damage. Each float’s servo and linkages (required) mount internally for clean looks.

Help your sailplane flying buddies quickly reach altitude. Just add a servo and the optional, machined aluminum Sailplane Tow Release (GPMA4567).

Tilex Mildew Root Penetrator And Remover With Bleach, Spray Bottle, 32 Ounces, Tilex

Tilex Mildew Root Penetrator and Remover with Bleach, Spray Bottle, 32 Ounces

About this item

Important Made in USA Origin Disclaimer: For certain items sold by Walmart on Walmart. com, the displayed country of origin information may not be accurate or consistent with manufacturer information. For updated, accurate country of origin data, it is recommended that you rely on product packaging or manufacturer information.

Tilex Mildew Root Penetrator and Remover Spray with Bleach kills mildew at its root, and cleans it away with ease. This thick foam spray formula clings tile surfaces, penetrating deeper to kill mildew at the root. Use this mildew root penetrator and remover spray on hard, nonporous surfaces such as grout, tile, tubs, sinks, counters, shower doors, vinyl curtains, glass, plastic, no wax floors and windowsills with no scrubbing required. And with this bottle's Smart Tube technology you are guaranteed to spray every drop. Killing and cleaning away mold has never been easier. Spray your way to a sparkling clean bathroom with Tilex.

About this item

Important Made in USA Origin Disclaimer: For certain items sold by Walmart on Walmart. com, the displayed country of origin information may not be accurate or consistent with manufacturer information. For updated, accurate country of origin data, it is recommended that you rely on product packaging or manufacturer information.

Tilex Mildew Root Penetrator and Remover Spray with Bleach kills mildew at its root, and cleans it away with ease. This thick foam spray formula clings tile surfaces, penetrating deeper to kill mildew at the root. Use this mildew root penetrator and remover spray on hard, nonporous surfaces such as grout, tile, tubs, sinks, counters, shower doors, vinyl curtains, glass, plastic, no wax floors and windowsills with no scrubbing required. And with this bottle's Smart Tube technology you are guaranteed to spray every drop. Killing and cleaning away mold has never been easier. Spray your way to a sparkling clean bathroom with Tilex.

One 32 ounce spray bottle of Tilex Mildew Root Penetrator and Remover with Bleach

Kills mildew at its root and cleans it away with ease

Safe for use on an array of hard, nonporous surfaces throughout your home

No scrubbing required

Smart Tube technology guarantees you will spray every drop

Warnings:

Causes substantial but temporary eye injury and can irritate skin. For sensitive skin or prolonged use, wear gloves. Avoid contact with eyes and skin. If contact occurs, rinse with water for 15 minutes. Vapors may irritate eyes, nose, throat, and lungs. Use only in well-ventilated areas. Keep out of reach of children.

Ingredients:

Water, sodium hypochlorite, alkyl dimethyl benzyl ammonium chloride, dimethicone/silica/PEG distearate antifoam, fragrance, lauramine oxide, sodium hydroxide, sodium silicate. Contains no phosphorus.

Directions:

For mildew removal, spray 6 to 8 inches from surface until thoroughly covered. Allow foam to deeply penetrate. Wipe with a wet sponge or cloth, and rinse. Heavy mildew buildup may require longer contact time or 2 cleanings. To disinfect and kill mildew on hard nonporous surfaces, spray surface until thoroughly wet, let stand 5 minutes and rinse. To kill mold and mildew on hard porous surfaces, spray surface until thoroughly wet, let stand 10 minutes and rinse. Repeat application.

Specifications

Toradol - Pain Relief, Dolotor

Toradol is used for the short-term (up to 5 days) treatment of moderate or severe pain (usually after surgery), alone or in combination with other medicines.

Use Toradol as directed by your doctor. Toradol may be taken with food if it upsets your stomach. Taking it with food may not decrease the risk of stomach or bowel problems (such as bleeding or ulcers) that may occur while taking Toradol. Talk with your doctor or pharmacist if you experience persistant stomach upset. Do not use this medication for more than 5 days. Toradol is not for the treatment of mild to moderate or chronic pain (e. g. headache). Ask your health care provider any questions you may have about how to use Toradol.

Drug Class and Mechanism

Toradol is an NSAID. It reduces inflammation by preventing certain chemicals (prostaglandins) from being produced by the injured tissue.

If you miss a dose of Toradol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Toradol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Toradol out of the reach of children and away from pets.

Do not use Toradol if: you are allergic to any ingredient in Toradol; you have had a severe allergic reaction (e. g. severe rash, hives, breathing difficulties, dizziness) to aspirin or an NSAID (e. g. ibuprofen, naproxen, celecoxib) ; you are taking an aminoglycoside (e. g. gentamicin), heparin, methotrexate, probenecid, tacrolimus, aspirin, or another NSAID (e. g. ibuprofen, celecoxib); you are breast-feeding, in labor or delivery, or you are scheduled to have surgery; you have a history of ulcers or severe stomach problems (e. g. bleeding, perforation); you are in your second or third trimester of pregnancy; you have severe kidney problems (including risk for kidney failure), or you have or are at risk for bleeding problems (e. g. stroke, hemorrhage). Contact your doctor or health care provider right away if any of these apply to you.

Important. Toradol may cause drowsiness or dizziness. Do not drive, operate machinery or do anything else that could be dangerous until you know how you react to Toradol. Using Toradol alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks. Do not take other anti-inflammatory medicines while you are taking Toradol. This includes any medicine that contains aspirin, ibuprofen, naproxen, and many prescription medicines. If you have questions about which medicines are anti-inflammatory agents, ask your doctor or pharmacist. If you are taking aspirin, prescribed by your doctor for reasons such as heart attack or stroke prevention (usually 81 to 325 mg per day), talk with your doctor before using Toradol. If you drink more than 3 alcohol-containing drinks a day, do not take Toradol without first discussing it with your doctor. Additional monitoring of your dose or condition may be necessary if you are taking amphetamines (e. g. dextroamphetamine), bisphosphonates (e. g. alendronate), or diuretics or "water pills" (e. g. hydrochlorothiazide). Lab tests may be required to monitor therapy or to check for side effects. Be sure to follow all doctor and lab appointments. Toradol is not recommended for use in children younger than 16 years of age. Safety and effectiveness have not been confirmed. Pregnancy and breast-feeding: If you become pregnant, discuss with your doctor the benefits and risks of using Toradol during pregnancy. Toradol is excreted in breast milk. Do not breast-feed while taking Toradol.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome: constipation; diarrhea; dizziness; drowsiness; gas; headache; indigestion; mouth sores; nausea; purple patches under the skin; stomach fullness; stomach pain; sweating; swelling; vomiting. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black stools; dark urine or pale stools; fainting; fluid retention; hallucinations; meningitis; persistent stomach/abdominal pain; pounding in the chest; psychosis; rectal bleeding; seizures; severe and continuing nausea; shortness of breath; stomach perforation; tightness in chest; tremors; ulcers; unusual bleeding or bruising; unusual fatigue; vomit that looks like coffee grounds; yellowing of the skin or eyes.

Toradol is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

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