Town Of Exeter, Ri - Town Of Exeter, Ri, Exter

Transfer Station Permits

Transfer Station Permits are available during regular Town Hall hours ​Monday-Friday 9:00 am - 4:00 pm

For privileges 9/1/2016-8/31/2017 Annual Permit $150.00 Second Permit $ 70.00 Senior Citizens (65+) $ 70.00 Single Use Permit $ 50.00 Special Needs Per mit $ 120.00

Extended Town Hall hours Aug 29, 30, & 31 9:00 a. m. – 6:00 p. m September 1 & 2 9:00 a. m. – 6:00 p. m. Sat, Sept 10 7:30 a. m. – 3:30 p. m.

Click here for Transfer Station Information

FY 2016-17 Tax Rate For fiscal year 2016-17, the Town of Exeter's Real Estate Tax Rate is $15.94.

Democratic Primary ​ Tuesday, September 13, 2016 Polls open at 7:00 A. M. and close at 8:00 P. M.

Polling Places: Precinct 1101 Blessed Kateri Tekakwith Church 84 Exeter Road

Precinct 1102 Metcalf School 30 Nooseneck Hill Road (Rt 3)

Precinct 1103 Job Corp Center 162 Main Street

Community Smart Resource Day

Saturday, September 24 10:00 A. M. - 3:00 P. M. Exeter Public Library ​ Come learn about local and state-wide resources in a welcoming and informal atmosphere.

Buy Oftasona P Betamethasone Online Without Prescriptions, Oftasona P

Betnovate is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid (cortisone-like medicine or steroid).

Use Betnovate as directed by your doctor.

Betnovate is for use on the skin only. Do not get it in your eyes.

Wash your hands with soap and water before and after using this medicine.

Apply a thin layer of this medicine to the affected area of the skin. Rub it in gently.

Do not use cosmetics or other skin care products on the treated areas.

Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.

If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.

If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems.

If you miss a dose of Betnovate, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For redness, itching, and swelling of the skin:

Adults: Apply to the affected area of the skin one to three times per day.

Children: Use and dose must be determined by your doctor.

Ask your health care provider any questions you may have about how to use Betnovate.

Store Betnovate at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Betnovate out of the reach of children and away from pets.

Active Ingredient: Betamethasone.

Do NOT use Betnovate if:

you are allergic to any ingredient in Betnovate

you are taking mifepristone

you have a systemic fungal infection

you are scheduled to have a smallpox vaccine

you have a certain bleeding disorder (idiopathic thrombocytopenic purpura).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Betnovate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of bleeding problems, heart problems (eg, congestive heart failure [CHF]), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, any mental or mood problems, or low blood potassium levels

if you have or have recently had a bacterial, fungal, malarial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; shingles; or a head or brain injury

if you have HIV infection or tuberculosis (TB), or if you have ever had a positive TB skin test

if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, infection, unexplained diarrhea, diverticulitis, ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus

if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)

if you have had any recent vaccinations (eg, smallpox)

if you have a history of joint surgery or any joint problems (eg, fracture, infection).

Some medicines may interact with Betnovate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aprepitant, clarithromycin, cyclosporine, diltiazem, erythromycin, itraconazole, ketoconazole, or troleandomycin because side effects, such as adrenal gland or nervous system problems (eg, seizures), may occur

Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), lithium, or rifampin because they may decrease Betnovate's effectiveness

Aspirin, live vaccines, mifepristone, or ritodrine because the risk of their side effects may be increased by Betnovate.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Betnovate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Betnovate may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

Tell your doctor or dentist that you take Betnovate before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Betnovate may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If you use Betnovate for an extended period of time, your body may not produce enough natural steroids for up to several months after you stop using it. Severe symptoms may occur if you experience injury, surgery, infection, or loss of blood electrolytes. Contact your doctor immediately if you experience any of these events. You may need to begin taking additional corticosteroids.

If you have had Betnovate injected into a joint and you experience increased pain along with swelling, decreased joint movement, fever, and general feeling of being unwell, contact your doctor.

Talk with your doctor before you receive any vaccine while you are using Betnovate.

Lab tests, including adrenal function tests and blood pressure monitoring, may be performed while you use Betnovate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Betnovate may have benzyl alcohol in it. Do not use it in newborns or infants. It may cause serious and sometimes fatal nervous system problems and other side effects.

Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Betnovate.

Betnovate should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Betnovate while you are pregnant. Betnovate is found in breast milk. If you are or will be breast-feeding while you use Betnovate, check with your doctor. Discuss any possible risks to your baby.

If you suddenly stop taking Betnovate, you may have withdrawal symptoms, These may include unbalanced hormones (in both men and women).

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; clumsiness; dizziness; facial flushing; general body discomfort; headache; increased appetite; increased sweating; lightheadedness; nausea; nervousness; sleeplessness; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual periods; changes in skin color; chest pain; easy bruising or bleeding; irregular heartbeat; mental or mood changes (eg, depression); muscle pain, wasting, or weakness; seizures; severe nausea or vomiting; sudden severe dizziness or headache; swelling of feet or legs; symptoms of infection (eg, chills, fever, sore throat); tendon or bone pain; thinning of the skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Fungizid Ratiopharm 200 Mg Vaginaltabletten Pzn 03292397 Versandkostenfrei In Der Online Apotheke Be

FUNGIZID ratiopharm 200 mg Vaginaltabletten 3 Stuck

Das Praparat ist ein Arzneimittel zur Behandlung von Pilzerkrankungen der Scheide. Clotrimazol, der Wirkstoff des Arzneimittels hemmt das Wachstum und die Vermehrung von Pilzzellen wie z. B. Sprosspilzen (Hefen) sowie eine Reihe weiterer Pilze und einiger Bakterien.

Es wird angewendet bei - infektiosem Ausfluss bedingt durch Candida - Entzundungen der Scheide durch Pilze (meist Candida) - Superinfektionen mit Clotrimazol-empfindlichen Bakterien

Fuhren Sie die Vaginaltabletten abends in Ruckenlage bei leicht angezogenen Beinen mit Hilfe des Applikators moglichst tief in die Scheide ein.

Hinweis: Bei gleichzeitiger Infektion der Schamlippen und angrenzender Bereiche sollte eine lokale Behandlung mit der dafur vorgesehenen Anwendungsform (z. B. Creme) erfolgen. Bei arztlich diagnostizierten Entzundungen von Eichel und Vorhaut des Partners durch Pilze sollte der Partner ebenfalls behandelt werden.

Die Behandlung sollte zweckma?igerweise nicht wahrend der Regelblutung (Menstruation) durchgefuhrt werden bzw. vor deren Beginn abgeschlossen sein. Eine Behandlung wahrend der Menstruation sollte nur bei ausgepragten Krankheitszeichen durchgefuhrt werden.

Anwendung in der Schwangerschaft: Wenn eine Behandlung wahrend der Schwangerschaft unerlasslich ist, sollte die Anwendung der Vaginaltabletten entweder ohne Applikator erfolgen oder es sollte die Behandlung durch den Arzt durchgefuhrt werden.

Wenden Sie das Praparat immer genau nach der Anweisung an. Bitte fragen Sie bei Ihrem Arzt oder Apotheker nach, wenn Sie sich nicht ganz sicher sind.

Falls vom Arzt nicht anders verordnet, ist die ubliche Dosis Fuhren Sie 1-mal taglich - und zwar abends - an 3 aufeinander folgenden Tagen 1 Vaginaltablette in die Scheide ein.

Behandlungsdauer: Sollte 4 Tage nach Behandlungsbeginn keine Besserung eingetreten sein oder sollten sich die Beschwerden verschlimmert haben, muss ein Arzt aufgesucht werden. Bitte sprechen Sie mit Ihrem Arzt oder Apotheker, wenn Sie den Eindruck haben, dass die Wirkung des Arzneimittels zu stark oder zu schwach ist.

Uberdosierung: Vergiftungen sind bei au?erlicher Anwendung nicht zu erwarten.

Vergessene Anwendung: Wenden Sie beim nachsten Mal auch nur eine Vaginaltablette an und setzen die Behandlung wie empfohlen fort.

Therapieabbruch: Wichtig fur den Behandlungserfolg ist eine regelma?ige und ausreichend lange Anwendung. Wenn Sie dies dennoch nicht tun, ist eine Wiederkehr der Beschwerden zu befurchten, da Ihre Pilzinfektion wahrscheinlich noch nicht richtig ausgeheilt ist. Wenn Sie weitere Fragen zur Anwendung des Arzneimittels haben, fragen Sie Ihren Arzt oder Apotheker.

Zusammensetzung FUNGIZID ratiopharm 200 mg Vaginaltabletten 3 Stuck bezogen auf 1 Tablette:

Es mussen keine besonderen Vorsichtsma?nahmen beachtet werden.

Verkehrstuchtigkeit und das Bedienen von Maschinen: Es sind keine besonderen Vorsichtsma?nahmen erforderlich.

Arzneimittel fur Kinder unzuganglich aufbewahren.

Gegenanzeigen FUNGIZID ratiopharm 200 mg Vaginaltabletten 3 Stuck.

Das Arzneimittel darf nicht angewendet werden, wenn Sie uberempfindlich (allergisch) gegen Clotrimazol oder einen der sonstigen Bestandteile sind.

Das Praparat darf in den folgenden Fallen nicht in der Selbstmedikation, sondern nur unter arztlicher Kontrolle angewendet werden: - in der Schwangerschaft (besondere Vorsicht ist geboten bei der vaginalen Anwendung in den ersten 3 Monaten der Schwangerschaft); wenn eine Behandlung wahrend der Schwangerschaft unerlasslich ist, sollte die Behandlung nur nach Anweisung des Arztes erfolgen und ohne Applikator durchgefuhrt werden, - bei erstmaligem Auftreten der Erkrankung - wenn die Erkrankung haufiger als 4-mal im Verlauf der vergangenen 12 Monate aufgetreten ist - bei Patientinnen unter 18 Jahren

Hinweise FUNGIZID ratiopharm 200 mg Vaginaltabletten 3 Stuck.

Es mussen keine besonderen Vorsichtsma?nahmen beachtet werden.

Verkehrstuchtigkeit und das Bedienen von Maschinen: Es sind keine besonderen Vorsichtsma?nahmen erforderlich.

Arzneimittel fur Kinder unzuganglich aufbewahren.

Nebenwirkungen FUNGIZID ratiopharm 200 mg Vaginaltabletten 3 Stuck.

Wie alle Arzneimittel kann auch dieses Nebenwirkungen haben, die aber nicht bei jedem auftreten mussen. Bei der Bewertung von Nebenwirkungen werden folgende Haufigkeitsangaben zugrunde gelegt:

Sehr haufig mehr als 1 Behandelter von 10

Haufig 1 bis 10 Behandelte von 100

Gelegentlich 1 bis 10 Behandelte von 1.000

Selten 1 bis 10 Behandelte von 10.000

Sehr selten weniger als 1 Behandelter von 10.000

Nicht bekannt Haufigkeit auf Grundlage der verfugbaren Daten nicht abschatzbar

Gelegentlich: Hautreaktionen mit Stechen, Brennen und Rotungen.

Informieren Sie bitte Ihren Arzt oder Apotheker, wenn eine der aufgefuhrten Nebenwirkungen Sie erheblich beeintrachtigt oder Sie Nebenwirkungen bemerken, die nicht angegeben sind.

Wie wirkt der Inhaltsstoff des Arzneimittels?

Der Wirkstoff schadigt die au?ere Hulle, die sog. Zellmembran von Pilzen. Diese Hulle verliert somit einen Teil ihrer Funktionen, sie wird z. B. fur Nahrstoffe undurchlassiger - die Zelle hungert, oder Zellbestandteile treten aus und die Zelle lost sich auf. Je nach Wirkstoffkonzentration werden die Pilze dadurch in ihrem Wachstum und ihrer Vermehrung gehemmt oder direkt abgetotet. Der Wirkstoff ist au?erdem gegen bestimmte Bakterien wirksam.

Bitte informieren Sie Ihren Arzt oder Apotheker, wenn Sie andere Arzneimittel einnehmen/anwenden bzw. vor kurzem eingenommen/angewendet haben, auch wenn es sich um nicht verschreibungspflichtige Arzneimittel handelt.

Das Praparat vermindert die Wirksamkeit von anderen Arzneimitteln, die ebenfalls zur Behandlung von Pilzerkrankungen angewendet werden (Amphotericin und anderen Polyenantibiotika wie Nystatin und Natamycin).

Bei bestimmungsgema?er topischer (au?erlicher), auch vaginal lokaler Anwendung (in der Scheide) von Clotrimazol sind keine weiteren Wechselwirkungen bekannt und aufgrund der geringen Resorption von Clotrimazol auch nicht zu erwarten.

Clotrimazol sollte aus Vorsicht nicht in der Fruhschwangerschaft angewendet werden. Im 2. und 3. Drittel der Schwangerschaft sowie in der Stillzeit kann das Arzneimittel auf ausdruckliche Anweisung des Arztes angewendet werden. Wenn eine Behandlung wahrend der Schwangerschaft unerlasslich ist, sollte die Behandlung nur nach Anweisung des Arztes erfolgen und ohne Applikator durchgefuhrt werden.

Wenn eine Behandlung wahrend der Schwangerschaft unerlasslich ist, sollte die Anwendung der Vaginaltabletten entweder ohne Applikator erfolgen oder es sollte die Behandlung mit dem Arzneimittel durch den Arzt durchgefuhrt werden. In der Schwangerschaft darf die Behandlung mit dem Praparat nur nach Anweisung des Arztes erfolgen.

Kaufer von FUNGIZID ratiopharm 200 mg Vaginaltabletten kauften auch:

Zu Risiken und Nebenwirkungen lesen Sie die Packungsbeilage und fragen Sie Ihren Arzt oder Apotheker.

Anwendungsgebiete NASENSPRAY ratiopharm Erwachsene kons. frei

Schnupfen

Flie?schnupfen

Allergischer Schnupfen, z. B. Heuschnupfen

Nasennebenhohlenentzundung (Sinusitis)

Tubenkatarrh, mit Schnupfen

Warnhinweise NASENSPRAY ratiopharm Erwachsene kons. frei

Bei einer Allergie gegen einen der Wirkstoffe und/oder Hilfsstoffe halten Sie bitte Rucksprache mit ihrem Arzt oder Apotheker oder kontaktieren Sie uns:

Zusammensetzung (Wirkstoffe / Hilfsstoffe) bezogen auf 1 ml Spray:

1 mg Xylometazolin hydrochlorid

0,87 mg Xylometazolin

Gegenanzeigen NASENSPRAY ratiopharm Erwachsene kons. frei

Dieses Arzneimittel durfen sie nicht anwenden:

- bei Uberempfindlichkeit (Allergie) gegenuber einem der Bestandteile dieses Arzneimittels,

- bei einer bestimmten Form eines chronischen Schnupfens (Rhinitis sicca),

- bei Zustand nach operativer Entfernung der Zirbeldruse durch die Nase (transsphenoidaler Hypophysektomie) oder anderen operativen Eingriffen, die die Hirnhaut freilegen,

- bei Kindern unter 6 Jahren.

Hinweise NASENSPRAY ratiopharm Erwachsene kons. frei

Bei den folgenden Erkrankungen und Situationen durfen Sie dieses Arzneimittel nur nach Rucksprache mit Ihrem Arzt anwenden:

- bei einem erhohten Augeninnendruck, insbesondere Engwinkelglaukom,

- schweren Herz-Kreislauf-Erkrankungen (z. B. koronarer Herzkrankheit) und Bluthochdruck (Hypertonie),

- wenn Sie mit Monoaminooxidase-Hemmern (MAO-Hemmern) und anderen potentiell blutdrucksteigernden Arzneimitteln behandelt werden,

- Tumor der Nebenniere (Phaochromozytom),

- Stoffwechselstorungen, wie z. B. Uberfunktion der Schilddruse (Hyperthyreo-se) und Zuckerkrankheit (Diabetes mellitus),

- der Dauergebrauch von schleimhautabschwellenden Nasentropfen ohne Konservierungsstoffe kann zu einer chronischen Schwellung und schlie?lich zum Schwund der Nasenschleimhaut fuhren.

Kinder und altere Menschen:

Diese Arzneimittel darf nicht angewendet werden bei Kindern unter 6 Jahren.

Verkehrstuchtigkeit und das Bedienen von Maschinen:

Bei bestimmungsgema?en Gebrauch sind keine Beeintrachtigungen zu erwarten.

Bewahren Sie dieses Arzneimittel fur Kinder unzuganglich auf.

Verwenden Sie es nicht mehr nach Ablauf des angegebenen Haltbarkeitsdatums.

Zu Risiken und Nebenwirkungen lesen Sie die Packungsbeilage und fragen Sie Ihren Arzt oder Apotheker.

Anwendungsgebiete GINKOBIL ratiopharm 120 mg Filmtabletten

Leistungsstorungen durch Veranderungen im Gehirn (Demenz), wie:

Konzentrationsschwache

Gedachtnisstorungen

Warnhinweise GINKOBIL ratiopharm 120 mg Filmtabletten

Bei einer Allergie gegen einen der Wirkstoffe und/oder Hilfsstoffe halten Sie bitte Rucksprache mit ihrem Arzt oder Apotheker oder kontaktieren Sie uns:

Zusammensetzung (Wirkstoffe / Hilfsstoffe) bezogen auf 1 Tablette:

120 mg Ginkgoblatter-Trockenextrakt, extrahiert mit Aceton-Wasser (35-67:1)

29,4 mg Ginkgo-Flavonglycoside

6,0-8,4 mg Terpenlactone

3,36-4,08 mg Ginkgolid A-Ginkgolid B-Ginkgolid C (x:y:z)

3,12-3,84 mg Bilobalid

hochstens 0,6 Mikrogramm Ginkgolsauren

Gegenanzeigen GINKOBIL ratiopharm 120 mg Filmtabletten

Das Arzneimittel darf nicht eingenommen werden - wenn Sie uberempfindlich (allergisch) gegenuber Ginkgo biloba oder einem der sonstigen Bestandteile sind, - in der Schwangerschaft.

Hinweise GINKOBIL ratiopharm 120 mg Filmtabletten

Kinder Zur Anwendung dieses Arzneimittels in dieser Altersgruppe liegen keine ausreichenden Untersuchungen vor. Es soll deshalb bei Kindern und Heranwachsenden unter 18 Jahren nicht angewendet werden.

Arzneimittel fur Kinder unzuganglich aufbewahren.

Bei krankhaft erhohter Blutungsneigung (hamorrhagische Diathese) sowie bei gleichzeitiger Behandlung mit blutgerinnungshemmenden Arzneimitteln sollte dieses Arzneimittel nur nach Rucksprache mit einem Arzt angewendet werden.

Da es einzelne Hinweise darauf gibt, dass Ginkgo-haltige Praparate die Blutungsbereitschaft erhohen konnten, sollte dieses Arzneimittel vorsichtshalber vor einer Operation abgesetzt werden. Informieren Sie bitte rechtzeitig Ihren Arzt, wenn Sie das Praparat eingenommen haben, damit er uber das weitere Vorgehen entscheiden kann. Falls bei Ihnen ein Krampfleiden (Epilepsie) bekannt ist, halten Sie vor Einnahme des Arzneimittels bitte Rucksprache mit Ihrem Arzt.

Zu Risiken und Nebenwirkungen lesen Sie die Packungsbeilage und fragen Sie Ihren Arzt oder Apotheker.

Anwendungsgebiete PARACETAMOL ratiopharm 500 mg Tabletten

Leichte bis ma?ig starke Schmerzen, wie:

Kopfschmerzen

Regelschmerzen

Zahnschmerzen

Fieber

Warnhinweise PARACETAMOL ratiopharm 500 mg Tabletten

Bei einer Allergie gegen einen der Wirkstoffe und/oder Hilfsstoffe halten Sie bitte Rucksprache mit ihrem Arzt oder Apotheker oder kontaktieren Sie uns:

Zusammensetzung (Wirkstoffe / Hilfsstoffe) bezogen auf 1 Tablette:

500 mg Paracetamol

Gegenanzeigen PARACETAMOL ratiopharm 500 mg Tabletten

Was spricht gegen eine Anwendung?

Immer: - Uberempfindlichkeit gegen die Inhaltsstoffe

Unter Umstanden - sprechen Sie hierzu mit Ihrem Arzt oder Apotheker: - Eingeschrankte Leberfunktion (z. B. durch chronischen Alkoholmissbrauch oder Leberentzundung) - Eingeschrankte Nierenfunktion - Gilbert-Syndrom (Meulengracht-Krankheit) - Alkoholmissbrauch

Welche Altersgruppe ist zu beachten? - Kinder unter 3 Jahren: Das Arzneimittel sollte in dieser Gruppe in der Regel nicht angewendet werden. Es gibt Praparate, die von der Wirkstoffstarke und/oder Darreichungsform besser geeignet sind.

Was ist mit Schwangerschaft und Stillzeit? - Schwangerschaft: Wenden Sie sich an Ihren Arzt. Es spielen verschiedene Uberlegungen eine Rolle, ob und wie das Arzneimittel in der Schwangerschaft angewendet werden kann. - Stillzeit: Es gibt nach derzeitigen Erkenntnissen keine Hinweise darauf, dass das Arzneimittel wahrend der Stillzeit nicht angewendet werden darf.

Ist Ihnen das Arzneimittel trotz einer Gegenanzeige verordnet worden, sprechen Sie mit Ihrem Arzt oder Apotheker. Der therapeutische Nutzen kann hoher sein, als das Risiko, das die Anwendung bei einer Gegenanzeige in sich birgt.

Hinweise PARACETAMOL ratiopharm 500 mg Tabletten

Was sollten Sie beachten? - Bei dauerhafter Anwendung von Schmerzmitteln konnen Kopfschmerzen auftreten, die durch das Schmerzmittel erzeugt werden. Sprechen Sie mit Ihrem Arzt, um zu verhindern, dass Ihre Kopfschmerzen chronisch werden. - Die gewohnheitsma?ige Anwendung von Schmerzmitteln kann zu einer dauerhaften Nierenschadigung fuhren. Werden mehrere Schmerzmittel kombiniert, oder sind in einem Schmerzmittel mehrere Wirkstoffe enthalten, erhoht sich das Risiko dafur. - Achtung: Bei regelma?igem bzw. hohem Alkoholgenuss kann es durch eine evtl. schon bestehende Leberschadigung zu lebensbedrohlichen Zustanden kommen, wenn das Arzneimittel noch zusatzlich angewendet wird. - Vorsicht bei Allergie gegen Schmerzmittel! - Vorsicht bei Allergie gegen Bindemittel (z. B. Carboxymethylcellulose mit der E-Nummer E 466)! - Es kann Arzneimittel geben, mit denen Wechselwirkungen auftreten. Sie sollten deswegen generell vor der Behandlung mit einem neuen Arzneimittel jedes andere, das Sie bereits anwenden, dem Arzt oder Apotheker angeben. Das gilt auch fur Arzneimittel, die Sie selbst kaufen, nur gelegentlich anwenden oder deren Anwendung schon einige Zeit zuruckliegt.

Gegenanzeigen GRIPPOSTAD C Hartkapseln

Das Arzneimittel darf NICHT eingenommen werden

wenn Sie uberempfindlich (allergisch) gegen Paracetamol, Ascorbinsaure, Coffein, Chlorphenaminmaleat oder einen der sonstigen Bestandteile von dem Arzneimittel sind

falls Sie unter schweren Nierenfunktionsstorungen leiden

wenn Sie an einer schweren Beeintrachtigung der Leberfunktion leiden

non Kindern unter 12 Jahren

wenn Sie schwanger sind

wenn Sie stillen.

Hinweise GRIPPOSTAD C Hartkapseln

Besondere Vorsicht bei der Einnahme von dem Arzneimittel ist erforderlich

Das Arzneimittel sollte nur mit besonderer Vorsicht bzw. nach Rucksprache mit dem Arzt angewendet werden:

wenn bei Ihnen eine Nierenfunktionsstorung vorliegt

wenn Sie an einer Beeintrachtigung der Leberfunktion leiden

bei angeborenem vermehrtem Bilirubin-Gehalt des Blutes (Gilbert-Syndrom oder Meulengracht-Krankheit)

wenn Sie unter Nierensteinen aus Oxalat (Oxalat-Urolithiasis) leiden

wenn Sie unter bestimmten Erkrankungen, bei denen zuviel Eisen im Korper gespeichert wird (Thalassamie, Hamochromatose, sideroblastische Anamie), leiden

wenn Sie chronisch alkoholkrank sind

wenn bei Ihnen eine Verengung des Magenausgangs (pyloroduodenale Obstruktion) und/oder eine Verengung des Blasenausgangs (Blasenhalsobstruktion) vorliegen

wenn Sie unter einer Erhohung des Augeninnendrucks (Engwinkelglaukom) leiden

wenn Sie unter Magen - und/oder Zwolffingerdarm-Geschwuren (Ulcus ventriculi bzw. Ulcus duodeni) leiden

wenn bei Ihnen eine Schilddrusenuberfunktion (Hyperthyreose) vorliegt

wenn Sie unter Herzrhythmusstorungen leiden

bei Angststorungen.

Wenn sich die Beschwerden verschlimmern, keine Besserung eintritt oder weitere Beschwerden hinzukommen sowie bei hohem Fieber muss der Arzt aufgesucht werden.

Ohne arztlichen oder zahnarztlichen Rat sollten Sie Paracetamol-haltige Arzneimittel (wie z. B. das Arzneimittel) allgemein nur wenige Tage und nicht in erhohter Menge einnehmen.

Bei langerem und hoch dosiertem, au?erhalb der empfohlenen Dosierung und der empfohlenen Dauer der Anwendung liegendem Gebrauch von Arzneimitteln, die Schmerzmittel enthalten (wie z. B. dem Arzneimittel), konnen Kopfschmerzen auftreten, die nicht durch erhohte Dosen des Arzneimittels behandelt werden durfen.

Eine Uberschreitung der empfohlenen Dosis kann, wie bei allen Arzneimitteln, die Paracetamol enthalten (wie z. B. das Arzneimittel), zu schweren Leberschaden fuhren. In diesem Fall ist eine umgehende arztliche Behandlung erforderlich.

Bei gleichzeitiger Einnahme anderer Paracetamol-haltiger Arzneimittel sollte sichergestellt werden, dass die maximale Tagesdosis an Paracetamol nicht uberschritten wird. Bitte fragen Sie Ihren Arzt oder Apotheker, ob es sich bei den von Ihnen gleichzeitig eingenommenen Arzneimitteln um Paracetamol-haltige Arzneimittel handelt und ob die Dosierung angepasst werden muss.

Bei der Einnahme hoher Dosen von dem Arzneimittel konnen durch die enthaltene Ascorbinsaure (Vitamin C) bei Patienten mit erythrozytarem Glucose-6-phosphat-Dehydrogenase-Mangel (eine erbliche Storung des Stoffwechsels der roten Blutzellen) in Einzelfallen schwere Hamolysen (Auflosung der roten Blutzellen) auftreten. Daher sollte die empfohlene Dosierung nicht uberschritten werden.

Wenn Sie zu Nierensteinen neigen besteht bei Einnahme gro?er Mengen von dem Arzneimittel durch die enthaltene Ascorbinsaure (Vitamin C) die Gefahr, dass sich Nierensteine (Calciumoxalatsteine) bilden.

Verkehrstuchtigkeit und das Bedienen von Maschinen

Dieses Arzneimittel kann auch bei Anwendung im empfohlenen Dosisbereich das Reaktionsvermogen so weit verandern, dass die Fahigkeit zur aktiven Teilnahme am Stra?enverkehr und/oder zum Bedienen von Maschinen beeintrachtigt wird. Dies gilt in verstarktem Ma?e in Zusammenwirken mit Alkohol.

Zu Risiken und Nebenwirkungen lesen Sie die Packungsbeilage und fragen Sie Ihren Arzt oder Apotheker.

Anwendungsgebiete FENISTIL Gel

Juckende Hauterkrankungen, wie:

Allergische Hauterkrankung

Ekzem

Nesselausschlag

Insektenstiche

Sonnenbrand

Verbrennungen, leichte

Warnhinweise FENISTIL Gel

Bei einer Allergie gegen einen der Wirkstoffe und/oder Hilfsstoffe halten Sie bitte Rucksprache mit ihrem Arzt oder Apotheker oder kontaktieren Sie uns:

Zusammensetzung (Wirkstoffe / Hilfsstoffe) bezogen auf 1 g Gel:

1 mg Dimetinden maleat

0,716 mg Dimetinden

Gegenanzeigen FENISTIL Gel

Das Arzneimittel darf nicht angewendet werden,

- wenn Sie uberempfindlich (allergisch) gegenuber Dimetindenmaleat oder einem der sonstigen Bestandteile des Arzneimittels sind.

- zur Behandlung einer bekannten Insektengiftallergie - hierfur stehen Arzneimittel in anderen Darreichungsformen zur Verfugung.

- zur gro?flachigen Anwendung.

- auf geschadigter Haut.

Das Praparat ist nicht zur Anwendung auf gro?en, insbesondere verletzten oder entzundeten Hautflachen vorgesehen, dies gilt speziell fur Sauglinge und Kleinkinder.

Hinweise FENISTIL Gel

Besondere Vorsicht bei der Anwendung des Arzneimittels ist erforderlich

Die behandelten Hautareale sollen nicht der direkten Sonnenstrahlung ausgesetzt werden.

Verkehrstuchtigkeit und das Bedienen von Maschinen:

Es sind keine Auswirkungen bekannt.

Zu Risiken und Nebenwirkungen lesen Sie die Packungsbeilage und fragen Sie Ihren Arzt oder Apotheker.

Anwendungsgebiete CROMO RATIOPHARM Augentropfen Einzeldosis

Allergische Bindehautentzundung, z. B. Fruhjahrskatarrh (Konjunktivitis vernalis) oder bei Heuschnupfen

Warnhinweise CROMO RATIOPHARM Augentropfen Einzeldosis

Bei einer Allergie gegen einen der Wirkstoffe und/oder Hilfsstoffe halten Sie bitte Rucksprache mit ihrem Arzt oder Apotheker oder kontaktieren Sie uns:

Zusammensetzung (Wirkstoffe / Hilfsstoffe) bezogen auf 0,5 ml Losung = 1 Behaltnis:

10 mg Cromoglicinsaure, Dinatriumsalz

9,14 mg Cromoglicinsaure

+ Natronlauge zur pH-Wert-Einstellung

+ Salzsaure zur pH-Wert-Einstellung

+ Wasser fur Injektionszwecke

Gegenanzeigen CROMO RATIOPHARM Augentropfen Einzeldosis

Das Arzneimittel darf nicht angewendet werden

wenn Sie uberempfindlich (allergisch) gegen Natriumcromoglicat oder einen der sonstigen Bestandteile sind.

Auch schon bei Verdacht auf eine allergische Reaktionslage ist ein erneuter Kontakt unbedingt zu vermeiden.

Hinweise CROMO RATIOPHARM Augentropfen Einzeldosis

Bei Entzundungen, auch bei allergischer Bindehautentzundung, ist der Augenarzt zu befragen, ob trotz der Beschwerden weiterhin Kontaktlinsen getragen werden durfen. Wenn der Augenarzt das Tragen von Kontaktlinsen gestattet, ist Folgendes zu beachten:

Nehmen Sie Kontaktlinsen vor dem Eintropfen heraus, und setzen Sie diese fruhestens 15 Minuten nach dem Eintropfen wieder ein.

Verkehrstuchtigkeit und das Bedienen von Maschinen

Dieses Arzneimittel beeinflusst unmittelbar nach der Anwendung fur wenige Minuten die Sehleistung. Bevor Sie am Stra?enverkehr teilnehmen, ohne sicheren Halt arbeiten oder Maschinen bedienen, soll abgewartet werden, bis die Beeintrachtigung des Sehvermogens durch Schleiersehen vorubergegangen ist.

So konnen Sie bezahlen Wir akzeptieren als Zahlungsweisen Rechnung, Lastschrift, PayPal, Vorkasse, Amazon Payments, Sofortuberweisung und Kreditkarte.

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Diltiazem Medlineplus Drug Information, Tiazac

Diltiazem

Diltiazem is used to treat high blood pressure and to control angina (chest pain). Diltiazem is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have to pump as hard. It also increases the supply of blood and oxygen to the heart.

High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

How should this medicine be used?

Diltiazem comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. The regular tablet is usually taken three or four times a day. The extended-release capsule and tablet are usually taken one or two times a day. Ask your pharmacist if you should take diltiazem with or without food, because instructions may vary with each product. Take diltiazem at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take diltiazem exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the extended-release capsules and tablets whole; do not chew or crush them.

Your doctor will probably start you on a low dose of diltiazem and gradually increase your dose, not more than once every 7 to 14 days if you are taking the extended-release tablet or capsule and not more than once every 1 to 2 days if you are taking the regular tablet.

If taken regularly, diltiazem may control chest pain, but it does not stop chest pain once it starts. Your doctor may give you a different medication to take when you have chest pain.

Diltiazem controls high blood pressure and chest pain (angina) but does not cure them. It may take up to 2 weeks before you feel the full benefit of diltiazem. Continue to take diltiazem even if you feel well. Do not stop taking diltiazem without talking to your doctor.

Other uses for this medicine

Diltiazem is also sometimes used to treat certain types of arrhythmias (abnormal heart rhythms). Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Pehadoxin & Pehadoxin Forte, Pehadoxin

Pehadoxin & Pehadoxin Forte

Phapros, Tbk, PT offers wide range of pharmaceuticals products which includes pehadoxin & pehadoxin forte. It belongs to antituberculous category. Indication: prophylaxis and treatment of pulmonary and extra-pulmonary tuberculous. Packaging: pehadoxin bottle contains 1500 tablets; pehadoxin forte bottle contains 350 tablets. Contact us for more information.

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Bacterfin, Bacterfin

bacterin

Once the deal closes, Bacterin will change its name to Xtant Medical Holdings Inc.

The plan to have the Bacterin sales force capitalize on that gap in the market by focusing on value and relative low cost of Bacterin 's products.

Braun Melsungen, Bacterin International Holdings, Berkeley Advanced Materials, BioMimetic Therapeutics, Cryolife, Exactech, Globus Medical, Graftys SAS, Integra Life Sciences Holdings, Johnson and Johnson, LifeNet Health, Medtronic, Novabone Products, NuVasive, Olympus Biotech, Osteogenics Biomedical, RTI Surgical, Sanofi Aventis, Scient'x/Alphatec Spine, Smith & Nephew, Synthes and Tornier.

AAP Implante Allosource Alphatec Amgen Angel Biotechnology ApaTech Arthrocare Atheriocyte Medical Systems Inc Athersys Azelon Pharmaceuticals Bacterin Baxter Berkeley Advanced Biomaterials Inc Biocomposites Biocoral Biological Therapies Biomatlante Biomet BioMimetic Therapeutics BioSET BioTissue BonAlive Biomaterials Bone Biologics Bone Solutions Bone Therapeutics BoneSupport Brazilian Unified Health System (SUS) Cardium Therapeutics Celltech Centre for Devices and Radiological Health (CDRH) Ceramisys Cerapedics co.

A vaccination program has commenced using a commercial killed bacterin developed for turkeys.

Other Prominent Vendors: Aastrom Biosciences, Acologix, Advanced Cell Technology, Arteriocyte, Athersys, Avita Medical, Bacterin International, Bellicum Pharmaceuticals, Bioactive Regenerative Therapeutics, BioCardia, BioLife Solutions, CryoLife, Cynata Therapeutics, Cytomedix, Cytori Therapeutics, Fibrocell Science, Forticell Bioscience, GE Healthcare, Geron, Histogenics, Humacyte, Integra Life Sciences and more.

NYSE MKT: ASM) Bacterin International (NYSE: BONE) Bio Blast Pharma Ltd.

This is the first product Bacterin has launched since I joined the company, and I have been very pleased with the process and the results," said Dan Goldberger, Bacterin president and CEO.

WNDM], Biovista, Excelimmune, Bacterin International [BIHI], PLC Medical Systems [PLCSF], International Holdings Inc.

Bacterin International also is working to build bone with a demineralized graft material that resembles a small sponge (hence, the moniker OsteoSponge).

OTCQX: OTCM), operator of Open, Transparent and Connected financial marketplaces, today announced Bacterin International Holdings, Inc.

Among the changes, Darrel Holmes was promoted to chief operating officer, taking over from Jesus Hernandez, who left Bacterin to pursue other interests.

About

Bacterin is an accredited tissue bank and medical device company that designs, processes, manufactures, and markets advanced medical products. Using designs focused on efficacy and safety for the patient, and functionality and ease of use for the surgeon, our innovative products fulfill niche needs in the industry.

It is important that you know and trust your allograft provider. We are a specialty tissue bank focused on processing and distributing quality, cost-effective allografts to you and your patients. If you have any questions or would like to learn more about Bacterin and our products, please contact our customer service team.

We take great pride in the role we serve as stewards to the gift of donation

The Gift of Donation

Many people are aware of the ability to donate vital organs to save lives, such as donation of your heart, lungs, or liver. What many may not be aware of is that you can also donate your musculoskeletal system which includes bones, cartilage, tendons, ligaments, and skin. Unlike organ donation which requires specific cross-matching between donors and recipients, tissue donation does not involve blood cells and thus a cross-match is not required. Donated tissue also has a longer window for transplant than organs as it can be stored for a specified period of time.

Please take the time to learn about organ and tissue donation and visit donatelife. net .

Donate Life America

Bacterin is a proud supporter of Donate Life America and the Donate Life Rose Parade Float. Check out how Bacterin supported the 2014 Donate Life Rose Parade Float in Pasadena, CA!

About Bacterin

We are an accredited tissue bank and medical device company specializing in advanced medical products that are easy to use and, most of all, safe for patients.

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Contact Us

600 Cruiser Lane Belgrade, MT 59714 USA

Phone: (+1) 406.388.0480 Fax: (+1) 406.388.1354 Email: info@Bacterin. com

Customer Service Phone: (+1) 888.886.9354 Fax: (+1) 406.388.3380 Email: cs@bacterin. com

© 2016 Bacterin International, Inc. All Rights Reserved.

Spirox, Inc, Spirox

Spirox, Inc. Announces Closing of $45MM Series C Financing

March 15, 2016 07:00 AM Eastern Daylight Time

MENLO PARK, Calif.--( BUSINESS WIRE )--Spirox Inc. a privately held medical device company, announced today the closing of a $45 million Series C round of financing led by KKR, a leading global investment firm. In leading the round, KKR joins a strong syndicate of existing investors in the company. Also participating in the financing is new investor HealthQuest Capital along with major existing shareholders Aisling Capital, Aperture Venture Partners and Venrock. Spirox, which is developing a novel, minimally invasive system to be used by Ear, Nose and Throat (ENT) physicians and plastic surgeons to treat patients with nasal obstruction, looks forward to partnering with KKR to help scale the business and better serve the greater ENT community.

"In addition to being a long-term capital partner, KKR’s experience scaling businesses provides us the opportunity to build for the future and help Spirox achieve the next level of growth,” said CEO Duke Rohlen. “We have a shared vision that will enable Spirox to continue to create cutting-edge innovations in order to provide breathing relief for millions of patients who need it.”

Spirox's technology is intended to treat a significant patient population. Each year, more than three million Americans see a physician for symptoms resulting from nasal obstruction and nearly one million procedures are performed to alleviate these symptoms. Standard treatment options include surgery to treat a deviated septum, surgery to reduce the size of the turbinates, and/or surgery to prevent nasal valve collapse. Although treating the nasal valve creates the greatest improvement in airflow for patients suffering from nasal obstruction, the morbidity associated with the current surgical options has resulted in limited use. Spirox aims to remove this barrier with its minimally invasive approach.

“Nasal obstruction is one of the most common complaints among patients who see an ENT physician, and the condition takes an immense toll on patient quality-of-life,” said Brent Senior, Chief of Rhinology, Allergy, and Endoscopic Skull Base Surgery at the University of North Carolina. “Spirox will help ENTs improve results and relieve suffering for their nasal obstruction patients by addressing nasal valve collapse—a primary but often untreated contributor to symptoms.”

As part of the transaction, Jim Momtazee, KKR Member and Head of the Firm’s health care investing team, will join the company’s Board of Directors. “There is a significant need in the ENT space for the technology Duke and his talented team have created to help people breathe better without having to undergo surgery,” said Mr. Momtazee. “We look forward to supporting Spirox to address this condition.”

For KKR, the investment is part of the firm's health care growth equity strategy, which is focused on high-growth companies for which KKR can be a unique partner in helping reach scale. KKR is funding the investment primarily from the balance sheet of KKR & Co. L. P. (NYSE:KKR).

ABOUT SPIROX, INC.

Spirox is a Menlo Park, CA-based medical device company that is focused on developing minimally invasive technologies that improve the quality of life for patients with nasal obstruction.

KKR is a leading global investment firm that manages investments across multiple asset classes including private equity, energy, infrastructure, real estate, credit and hedge funds. KKR aims to generate attractive investment returns by following a patient and disciplined investment approach, employing world?class people, and driving growth and value creation at the asset level. KKR invests its own capital alongside its partners' capital and brings opportunities to others through its capital markets business. References to KKR's investments may include the activities of its sponsored funds. For additional information about KKR & Co. L. P. (NYSE:KKR), please visit KKR's website at www. kkr. com and on Twitter @KKR_Co.

Contacts

Cyclophosphamide (Cytoxan), Ledoxan

Cyclophosphamide (Cytoxan)

Contents

General information

Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA. [1] [2] Route: IV, PO Extravasation: irritant. n/a

For conciseness and simplicity, HemOnc. org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex. Lexicomp. Medscape, UpToDate (courtesy of Lexicomp). or the prescribing information. [1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

11/16/1959: initial FDA approval

Also known as

Furazosin Generic Name Prazosin Online, Furazosin

Furazosin General Information

Furazosin - Pharmacology:

Furazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.

Furazosin for patients

Dizziness or drowsiness may occur after the first dose of this medicine. Avoid driving or performing hazardous tasks for the first 24 hours after taking this medicine or when the dose is increased. Dizziness, light-headedness or fainting may occur, especially when rising from a lying or sitting position. Getting up slowly may help lessen the problem. These effects may also occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot. While taking prazosin HCl, be careful in the amount of alcohol you drink. Also, use extra care during exercise or hot weather, or if standing for long periods. Check with your physician if you have any questions.

This description is suitable for active ingredient Prazosin

Furazosin Interactions

Furazosin has been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides - digitalis and digoxin; (2) hypoglycemics - insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives - chlordiazepoxide, diazepam, and phenobarbital; (4) antigout - allopurinol, colchicine, and probenecid; (5) antiarrhythmics - procainamide, propranolol. and quinidine; and (6) analgesics, antipyretics and anti-inflammatories - propoxyphene, aspirin, indomethacin, and phenylbutazone.

Addition of a diuretic or other antihypertensive agent to prazosin HCl has been shown to cause an additive hypotensive effect. This effect can be minimized by reducing the prazosin dose to 1 to 2mg three times a day, by introducing additional antihypertensive drugs cautiously and then by retitrating prazosin based on clinical response.

Drug/Laboratory Test Interactions

In a study on five patients given from 12 to 24 mg of prazosin per day for 10 to 14 days, there was an average increase of 42% in the urinary metabolite of norepinephrine and an average increase in urinary VMA of 17%. Therefore, false positive results may occur in screening tests for pheochromocytoma in patients who are being treated with prazosin. If an elevated VMA is found, prazosin should be discontinued and the patient retested after a month.

Furazosin Contraindications

Buy Heart Disease - Furorese Comp (Brand Name Aldactone) Online - Order Spironolactone - Purchase He

Common use Magnium and potassium-sparing diuretic and aldosterone antagonist. It competitively associates with aldosterone receptors in in the distal parts of the nephron. It has a diuretic effect, increases excretion of natrium ions and decreases excretion of potassium and magnium, decreases urinary acidity. The diuretic effect of the medicine is moderate and appears usually after 2-5 days of treatment and continues during 2-3 days after discontinuance of the medicine intake. A weak hypotension effect appear usually in 2-3 weeks of treatment. Aldactone is used in combination with other drugs to treat hypertension. It also facilitates removal of excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease.

Dosage and direction

Daily dose for adults in arterial hypertension, edema syndrome is 50-100 mg for adults. It should be divided into 1-2 intakes a day. On necessity the dose maybe gradually increased up to 200 mg a day. Duration of treatment is not less than two weeks. For other conditions such as chronic congestive heart failure, cirrhosis, nephrotic syndrome and others different dosage maybe recommended. Consult your doctor before you decide to take this medicine. Aldactone should be taken after a meal and the most preferable is a single dose before bedtime.

Precautions Do not drink alcohol as it increases some of the side effects of Aldactone. Avoid eating too much salt because excess of salt may cause your body to retain water and effectiveness of Aldactone decreases. It is recommended not to take salt substitutes or low-sodium milk products which contain potassium. Avoid becoming overheated or dehydrated during exercising. Talk with your doctor about amount of liquids you should consume. Do not stop using this medicine even if you feel improvement of your health if you are being treated for high blood pressure.

Contraindication Hypersensitivity, Addison disease, hypercaliemia, hyperpotassiemia, concomitant intake with potassium supplements or other potassium-sparing diuretics such as Aldactazide, amiloride (Midamor, Moduretic), triamterene (Dyrenium, Dyazide, Maxzide), hyponatriemia, chronic kidney failure, diabetic nephropathy, anuria, liver failure, diabetes at supposed chronic kidney failure, diabetic nephropathy, pregnancy, and some others. Please take this medicine only if it is advised by your doctor.

Possible side effect Side effects of the medicine include headache, diarrhea, cramps, drowsiness, rash, nausea, vomiting, impotence, irregular menstrual periods, and irregular hair growth. Fluid and electrolytes imbalance are likely, so patients should be monitored carefully. Enlargement of the breasts may also occur depending on dose and duration of therapy. This condition is usually reversible when you discontinue to take Aldactone.

This medicine can lower blood sodium levels while raising blood potassium levels. Excessively high potassium levels in blood sometimes cause potentially life-threatening abnormalities in heart rhythm. Therefore, Aldactone usually is not administered with other agents that can raise blood potassium levels. Aldactone can cause elevation of blood digoxin (Lanoxin) to toxic levels.

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Immediate medical attention in needed in case you overdosed intake of the medicine. Overdose symptoms may include drowsiness, confusion, red skin rash, nausea, vomiting, or diarrhea.

Aldactone should be stored at room temperature, below 25 C (77 F).

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use Magnium and potassium-sparing diuretic and aldosterone antagonist. It competitively associates with aldosterone receptors in in the distal parts of the nephron. It has a diuretic effect, increases excretion of natrium ions and decreases excretion of potassium and magnium, decreases urinary acidity. The diuretic effect of the medicine is moderate and appears usually after 2-5 days of treatment and continues during 2-3 days after discontinuance of the medicine intake. A weak hypotension effect appear usually in 2-3 weeks of treatment. Aldactone is used in combination with other drugs to treat hypertension. It also facilitates removal of excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease.

Dosage and direction

Daily dose for adults in arterial hypertension, edema syndrome is 50-100 mg for adults. It should be divided into 1-2 intakes a day. On necessity the dose maybe gradually increased up to 200 mg a day. Duration of treatment is not less than two weeks. For other conditions such as chronic congestive heart failure, cirrhosis, nephrotic syndrome and others different dosage maybe recommended. Consult your doctor before you decide to take this medicine. Aldactone should be taken after a meal and the most preferable is a single dose before bedtime.

Precautions Do not drink alcohol as it increases some of the side effects of Aldactone. Avoid eating too much salt because excess of salt may cause your body to retain water and effectiveness of Aldactone decreases. It is recommended not to take salt substitutes or low-sodium milk products which contain potassium. Avoid becoming overheated or dehydrated during exercising. Talk with your doctor about amount of liquids you should consume. Do not stop using this medicine even if you feel improvement of your health if you are being treated for high blood pressure.

Contraindication Hypersensitivity, Addison disease, hypercaliemia, hyperpotassiemia, concomitant intake with potassium supplements or other potassium-sparing diuretics such as Aldactazide, amiloride (Midamor, Moduretic), triamterene (Dyrenium, Dyazide, Maxzide), hyponatriemia, chronic kidney failure, diabetic nephropathy, anuria, liver failure, diabetes at supposed chronic kidney failure, diabetic nephropathy, pregnancy, and some others. Please take this medicine only if it is advised by your doctor.

Possible side effect Side effects of the medicine include headache, diarrhea, cramps, drowsiness, rash, nausea, vomiting, impotence, irregular menstrual periods, and irregular hair growth. Fluid and electrolytes imbalance are likely, so patients should be monitored carefully. Enlargement of the breasts may also occur depending on dose and duration of therapy. This condition is usually reversible when you discontinue to take Aldactone.

This medicine can lower blood sodium levels while raising blood potassium levels. Excessively high potassium levels in blood sometimes cause potentially life-threatening abnormalities in heart rhythm. Therefore, Aldactone usually is not administered with other agents that can raise blood potassium levels. Aldactone can cause elevation of blood digoxin (Lanoxin) to toxic levels.

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Immediate medical attention in needed in case you overdosed intake of the medicine. Overdose symptoms may include drowsiness, confusion, red skin rash, nausea, vomiting, or diarrhea.

Aldactone should be stored at room temperature, below 25 C (77 F).

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Buy Chlocodemin - Betamethasone - Online Without Prescriptions, Chlocodemin

Betnovate (Chlocodemin)

Betnovate is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid (cortisone-like medicine or steroid).

Use Betnovate as directed by your doctor.

Betnovate is for use on the skin only. Do not get it in your eyes.

Wash your hands with soap and water before and after using this medicine.

Apply a thin layer of this medicine to the affected area of the skin. Rub it in gently.

Do not use cosmetics or other skin care products on the treated areas.

Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.

If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.

If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems.

If you miss a dose of Betnovate, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For redness, itching, and swelling of the skin:

Adults: Apply to the affected area of the skin one to three times per day.

Children: Use and dose must be determined by your doctor.

Ask your health care provider any questions you may have about how to use Betnovate.

Store Betnovate at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Betnovate out of the reach of children and away from pets.

Active Ingredient: Betamethasone.

Do NOT use Betnovate if:

you are allergic to any ingredient in Betnovate

you are taking mifepristone

you have a systemic fungal infection

you are scheduled to have a smallpox vaccine

you have a certain bleeding disorder (idiopathic thrombocytopenic purpura).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Betnovate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of bleeding problems, heart problems (eg, congestive heart failure [CHF]), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, any mental or mood problems, or low blood potassium levels

if you have or have recently had a bacterial, fungal, malarial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; shingles; or a head or brain injury

if you have HIV infection or tuberculosis (TB), or if you have ever had a positive TB skin test

if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, infection, unexplained diarrhea, diverticulitis, ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus

if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)

if you have had any recent vaccinations (eg, smallpox)

if you have a history of joint surgery or any joint problems (eg, fracture, infection).

Some medicines may interact with Betnovate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aprepitant, clarithromycin, cyclosporine, diltiazem, erythromycin, itraconazole, ketoconazole, or troleandomycin because side effects, such as adrenal gland or nervous system problems (eg, seizures), may occur

Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), lithium, or rifampin because they may decrease Betnovate's effectiveness

Aspirin, live vaccines, mifepristone, or ritodrine because the risk of their side effects may be increased by Betnovate.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Betnovate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Betnovate may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

Tell your doctor or dentist that you take Betnovate before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Betnovate may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If you use Betnovate for an extended period of time, your body may not produce enough natural steroids for up to several months after you stop using it. Severe symptoms may occur if you experience injury, surgery, infection, or loss of blood electrolytes. Contact your doctor immediately if you experience any of these events. You may need to begin taking additional corticosteroids.

If you have had Betnovate injected into a joint and you experience increased pain along with swelling, decreased joint movement, fever, and general feeling of being unwell, contact your doctor.

Talk with your doctor before you receive any vaccine while you are using Betnovate.

Lab tests, including adrenal function tests and blood pressure monitoring, may be performed while you use Betnovate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Betnovate may have benzyl alcohol in it. Do not use it in newborns or infants. It may cause serious and sometimes fatal nervous system problems and other side effects.

Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Betnovate.

Betnovate should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Betnovate while you are pregnant. Betnovate is found in breast milk. If you are or will be breast-feeding while you use Betnovate, check with your doctor. Discuss any possible risks to your baby.

If you suddenly stop taking Betnovate, you may have withdrawal symptoms, These may include unbalanced hormones (in both men and women).

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; clumsiness; dizziness; facial flushing; general body discomfort; headache; increased appetite; increased sweating; lightheadedness; nausea; nervousness; sleeplessness; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual periods; changes in skin color; chest pain; easy bruising or bleeding; irregular heartbeat; mental or mood changes (eg, depression); muscle pain, wasting, or weakness; seizures; severe nausea or vomiting; sudden severe dizziness or headache; swelling of feet or legs; symptoms of infection (eg, chills, fever, sore throat); tendon or bone pain; thinning of the skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Omega-3 Fish Oil Supplements Benefits, Side Effects, And Uses, Omega-3

Omega-3 Fish Oil Supplements for Heart Disease

In the past 10 years, many Americans have turned to omega-3 fish oil supplements. which have benefits for healthy people and also those with heart disease .

Omega-3 fish oil contains both docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Omega-3 fatty acids are essential nutrients that are important in preventing and managing heart disease .

Findings show omega-3 fatty acids may help to:

The American Heart Association (AHA) recommends that everyone eats fish (particularly fatty, coldwater fish) at least twice a week. Salmon, mackerel, herring, sardines, lake trout, and tuna are especially high in omega-3 fatty acids. While foods are your best bet for getting omega-3s in your diet, fish oil supplements are also available for those who do not like fish. The heart-healthy benefits of regular doses of fish oil supplements are unclear, so talk to your doctor to see if they're right for you. If you have heart disease or high triglyceride levels. you may need even more omega-3 fatty acids. Ask your doctor if you should take higher doses of fish oil supplements to get the omega-3s you need.

How much omega-3 fish oil is safe?

The AHA says taking up to 3 grams of fish oil daily in supplement form is considered safe. Don't take more than that unless you discuss it with your doctor first.

Are there side effects with omega-3 fish oil?

Side effects from omega-3 fish oil may include:

Taking more than 3 grams of fish oil daily may increase the risk of bleeding.

If you want to take higher doses of omega-3 fish oil supplements, talk to your doctor first. Your doctor can guide you in supplementing your diet with omega-3 fish oil. Also, your doctor can monitor all aspects of your health if you take higher doses of fish oil. For people with very high triglyceride levels. prescription omega-3 preparations are also available.

WebMD Medical Reference Reviewed by Elizabeth Klodas, MD, FACC on March 25, 2015

Sources

National Medicines Comprehensive Database: "Fish Oil."

American Heart Association: "Fish and Omega 3 Fatty Acids."

Geleijnse J. M. J Hypertens, 2002; vol 20: p 1493.

Oh R. The Journal of the American Board of Family Practice . 2005; vol 18: pp 28-36.

© 2015 WebMD, LLC. All rights reserved.

Next Article

Radiant Heating, Radinat

Energy. gov

Radiant heating systems supply heat directly to the floor or to panels in the wall or ceiling of a house. The systems depend largely on radiant heat transfer -- the delivery of heat directly from the hot surface to the people and objects in the room via infrared radiation. Radiant heating is the effect you feel when you can feel the warmth of a hot stovetop element from across the room. When radiant heating is located in the floor, it is often called radiant floor heating or simply floor heating.

Radiant heating has a number of advantages. It is more efficient than baseboard heating and usually more efficient than forced-air heating because it eliminates duct losses. People with allergies often prefer radiant heat because it doesn’t distribute allergens like forced air systems can. Hydronic (liquid-based) systems use little electricity, a benefit for homes off the power grid or in areas with high electricity prices. Hydronic systems can use a wide variety of energy sources to heat the liquid, including standard gas - or oil-fired boilers, wood-fired boilers, solar water heaters, or a combination of these sources. For more on the different types of energy sources and heat distribution systems for home heating, explore our Energy Saver 101 infographic on home heating .

Despite its name, radiant floor heating depends heavily on convection, the natural circulation of heat within a room as air warmed by the floor rises. Radiant floor heating systems are significantly different from the radiant panels used in walls and ceilings. For this reason, the following sections discuss radiant floor heat and radiant panels separately.

Radiant Floor Heat

There are three types of radiant floor heat -- radiant air floors (air is the heat-carrying medium), electric radiant floors, and hot water (hydronic) radiant floors. You can further categorize these types by installation. Those that make use of the large thermal mass of a concrete slab floor or lightweight concrete over a wooden subfloor are called "wet installations,” and those in which the installer "sandwiches" the radiant floor tubing between two layers of plywood or attaches the tubing under the finished floor or subfloor are called "dry installations."

Types of Radiant Floor Heat

Air-Heated Radiant Floors

Air cannot hold large amounts of heat, so radiant air floors are not cost-effective in residential applications, and are seldom installed. Although they can be combined with solar air heating systems, those systems suffer from the obvious drawback of only producing heat in the daytime, when heating loads are generally lower. The inefficiency of trying to heat a home with a conventional furnace by pumping air through the floors at night outweighs the benefits of using solar heat during the day. Although some early solar air heating systems used rocks as a heat-storage medium, this approach is not recommended (see solar air heating systems ).

Electric Radiant Floors

Electric radiant floors typically consist of electric cables built into the floor. Systems that feature mats of electrically conductive plastic mounted on the subfloor below a floor covering such as tile are also available.

Because of the relatively high cost of electricity, electric radiant floors are usually only cost-effective if they include a significant thermal mass such as a thick concrete floor and your electric utility company offers time-of-use rates. Time-of-use rates allow you to "charge" the concrete floor with heat during off-peak hours (approximately 9 p. m. to 6 a. m.). If the floor's thermal mass is large enough, the heat stored in it will keep the house comfortable for eight to ten hours without any further electrical input, particularly when daytime temperatures are significantly warmer than nighttime temperatures. This saves a considerable number of energy dollars compared to heating at peak electric rates during the day.

Electric radiant floors may also make sense for home additions if it would be impractical to extend the heating system into the new space. However, homeowners should examine other options, such as mini-split heat pumps. which operate more efficiently and have the added advantage of providing cooling.

Hydronic Radiant Floors

Hydronic (liquid) systems are the most popular and cost-effective radiant heating systems for heating-dominated climates. Hydronic radiant floor systems pump heated water from a boiler through tubing laid in a pattern under the floor. In some systems, controlling the flow of hot water through each tubing loop by using zoning valves or pumps and thermostats regulates room temperatures. The cost of installing a hydronic radiant floor varies by location and depends on the size of the home, the type of installation, the floor covering, remoteness of the site, and the cost of labor.

Types of Floor Installations

Whether you use cables or tubing, the methods of installing electric and hydronic radiant systems in floors are similar.

So-called "wet" installations embed the cables or tubing in a solid floor and are the oldest form of modern radiant floor systems. The tubing or cable can be embedded in a thick concrete foundation slab (commonly used in "slab" ranch houses that don't have basements) or in a thin layer of concrete, gypsum, or other material installed on top of a subfloor. If concrete is used and the new floor is not on solid earth, additional floor support may be necessary because of the added weight. You should consult a professional engineer to determine the floor's carrying capacity.

Thick concrete slabs are ideal for storing heat from solar energy systems, which have a fluctuating heat output. The downside of thick slabs is their slow thermal response time, which makes strategies such as night or daytime setbacks difficult if not impossible. Most experts recommend maintaining a constant temperature in homes with these heating systems.

Due to recent innovations in floor technology, so-called "dry" floors, in which the cables or tubing run in an air space beneath the floor, have been gaining in popularity, mainly because a dry floor is faster and less expensive to build. But because dry floors involve heating an air space, the radiant heating system needs to operate at a higher temperature.

Some dry installations involve suspending the tubing or cables under the subfloor between the joists. This method usually requires drilling through the floor joists to install the tubing. Reflective insulation must also be installed under the tubes to direct the heat upward. Tubing or cables may also be installed from above the floor, between two layers of subfloor. In these instances, liquid tubing is often fitted into aluminum diffusers that spread the water's heat across the floor in order to heat the floor more evenly. The tubing and heat diffusers are secured between furring strips (sleepers), which carry the weight of the new subfloor and finished floor surface.

At least one company has improved on this idea by making a plywood subfloor material manufactured with tubing grooves and aluminum heat diffuser plates built into them. The manufacturer claims that this product makes a radiant floor system (for new construction) considerably less expensive to install and faster to react to room temperature changes. Such products also allow for the use of half as much tubing or cabling, because the heat transfer of the floor is greatly improved compared with more traditional dry or wet floors.

Floor Coverings

Ceramic tile is the most common and effective floor covering for radiant floor heating, because it conducts heat well and adds thermal storage. Common floor coverings like vinyl and linoleum sheet goods, carpeting, or wood can also be used, but any covering that insulates the floor from the room will decrease the efficiency of the system.

If you want carpeting, use a thin carpet with dense padding and install as little carpeting as possible. If some rooms, but not all, will have a floor covering, then those rooms should have a separate tubing loop to make the system heat these spaces more efficiently. This is because the water flowing under the covered floor will need to be hotter to compensate for the floor covering. Wood flooring should be laminated wood flooring instead of solid wood to reduce the possibility of the wood shrinking and cracking from the drying effects of the heat.

Radiant Panels

Wall - and ceiling-mounted radiant panels are usually made of aluminum and can be heated with either electricity or with tubing that carries hot water, although the latter creates concerns about leakage in wall - or ceiling-mounted systems. Most commercially available radiant panels for homes are electrically heated.

Like any type of electric heat, radiant panels can be expensive to operate, but they can provide supplemental heating in some rooms or can provide heat to a home addition when extending the conventional heating system is impractical.

Radiant panels have the quickest response time of any heating technology and -- because the panels can be individually controlled for each room—the quick response feature can result in cost and energy savings compared with other systems when rooms are infrequently occupied. When entering a room, the occupant can increase the temperature setting and be comfortable within minutes. As with any heating system, set the thermostat to a minimum temperature that will prevent pipes from freezing.

Radiant heating panels operate on a line-of-sight basis -- you'll be most comfortable if you're close to the panel. Some people find ceiling-mounted systems uncomfortable because the panels heat the top of their heads and shoulders more effectively than the rest of their bodies.

Learn More

Vista Amadores - Review Of Holiday Club Vista Amadores, Puerto Rico, Spain, Gamamax

just got back from a week at jardin amadores and got to say one of the best exchanges we have done. don't get me wrong its not perfect as its on a very steep hill and I wouldn't take my grandkids there as not enough to do but for a couple or a group who wants no hassle lovely spotless apartments it is spot on. we have stayed at vista a few years and enjoyed it there but the difference in places is massive. we had a two bed which was huge, but the best bit is the balcony. the sun gets on balcony around 12 and stays on till the sun goes down looking over amadores beach and watching the sun go down with a glass of wine was amazing. the place is well run nothing was to much trouble left us alone at the end of the day if I wanted to buy one I would go and see them! wish some of the restaurants would leave you alone when looking at the menu!

“ Nearly as good as it could be - just. ”

Gamamax (1 review)

Greater London, United Kingdom

Helpful staff when not bored. Better than expected food. Roomy apartment. Mediocre kitchen. Great views if higher than lower levels. Obtrusive selling schedules from reps. Not recommended for those with walking problems. Slightly tired property but fine for a week or two at m most. Worth a visit.

“ Fantastic sea views ”

whetstoneview (142 reviews)

Walsall, United Kingdom

We spent a week in a two bedroomed apartment 205. The bedrooms were both a good size, at either side of the living area. Each had a bathroom, one with bath and separate shower and the other with a large walk-in shower. One room had twin beds and the other had a double bed. Both had lots of storage space and there was a safe in the double room. The living area was large with a well fitted kitchen area with dishwasher, large fridge freezer, 4 ring electric hob and a combination microwave. There was also a toaster, coffee maker and electric kettle. The disappointing features were no conventional oven or grill and limited cutlery, crockery and cooking receptacles for the microwave. The quality of the fixtures was high - IKEA style, with a full range of glasses. The seating furniture was rather low with a large coffee table and a glass dining table with 5 chairs. The balcony was a fair size with a table, four chairs, 2 sunbeds, a small table and a clothes airer. The higher the room the better the view of the full expanse of the bay below. All rooms have a sea view and most get the sun in the afternoon. The resort is at the top of a steep hill which is ok if you like exercise, have a car or are happy to pay for taxis. There is a courtesy bus from the report to the bay twice each morning and afternoon. You can also go further up the hill, five minutes walk away to a shopping centre which has a range of restaurants, bars and small shops. There is also a Hiperdino supermarket which is reasonably priced and has a good range of products. There are no extra charges at the resort. A small welcome pack comprising a bottle of water, a litre of milk and tea, coffee etc was also supplied. Dishwasher tablets are provided as required but there was no washing up liquid or dishcloth. The room was cleaned twice during our week's stay with change of bed linen and towels. One drawback was the proximity of the resort to a busy road which did impact on sitting on the balcony and leaving the patio windows open at certain times of the day. There is a range of facilities including a gym, pool, squash court and sauna. The gym is somewhat dated so I got my exercise by running down the hill and walking back up each morning - a distance of around 1 kilometre each way. The pool was also in need of renovation but was quiet and surrounded by a good number of sunbeds. The resort is starting a period of refurbishment from April with new fittings, bathrooms, kitchens and furniture. I assume the public areas will also have a facelift. Free wifi is available in reception and the restaurant. Barbecue and tapas nights alternate each Thursday. We went to the tapas night which had a selection of dishes, including Beef Goulash, Meatballs and Paella. Not my idea of proper tapas but tasty. One disappointment was that all the different dishes were served at the same time onto one plate. The meal cost 12.50 euros which was a good price but not sure if I would recommend it because of presentation. I look forward to returning in the future to see what alterations are made.

Aleve - Pain Relief, Apromed

Pain Relief - Apromed (Brand name: aleve)

Aleve (naproxen) is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen works by reducing hormones that cause inflammation and pain in the body. It commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as:

osteoarthritis

kidney stones

rheumatoid arthritis

psoriatic arthritis

gout

ankylosing spondylitis

menstrual cramps

tendinitis

bursitis

Aleve is commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as:

osteoarthritis

kidney stones

rheumatoid arthritis

psoriatic arthritis

gout

ankylosing spondylitis

menstrual cramps

tendinitis

bursitis

Take Aleve exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Do not crush, chew, or break an extended-release or enteric-coated tablet. Swallow the pill whole. The extended-release pill is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time. The enteric-coated pill has a special coating to protect your stomach. Breaking the pill could damage this coating. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you take Aleve for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.

Since Aleve is sometimes taken only when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to Aleve (such as ibuprofen or ketoprofen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, or ketoprofen. Do not drink alcohol while taking Aleve. Alcohol can increase the risk of stomach bleeding caused by Aleve. Avoid prolonged exposure to sunlight.

Aleve can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF 15 or higher) when you are outdoors.

Store Aleve at room temperature away from moisture and heat.

Before taking Aleve:

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use Aleve just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Do not use this medication if you are allergic to Aleve, or if you have a history of allergic reaction to aspirin or other NSAIDs.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use Aleve:

a history of heart attack, stroke, or blood clot;

heart disease, congestive heart failure, high blood pressure;

a history of stomach ulcers or bleeding;

liver or kidney disease;

asthma;

polyps in your nose;

a bleeding or blood clotting disorder; or

if you smoke.

FDA pregnancy category C. Before using Aleve, tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking Aleve during the last 3 months of pregnancy may result in birth defects. Do not take Aleve during pregnancy unless your doctor has told you to. Aleve can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child younger than 2 years old without the advice of a doctor.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to Aleve (such as ibuprofen or ketoprofen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, or ketoprofen. Do not drink alcohol while taking Aleve. Alcohol can increase the risk of stomach bleeding caused by Aleve. Avoid prolonged exposure to sunlight. Aleve may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Aleve and seek medical attention or call your doctor at once if you have any of these serious side effects:

chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;

black, bloody, or tarry stools;

coughing up blood or vomit that looks like coffee grounds;

swelling or rapid weight gain;

urinating less than usual or not at all;

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

bruising, severe tingling, numbness, pain, muscle weakness; or

fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions).

Less serious Aleve side effects may include:

upset stomach, mild heartburn or stomach pain, diarrhea, constipation;

bloating, gas;

dizziness, headache, nervousness;

skin itching or rash;

blurred vision; or

ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Indomethacin, Indocin Drug Facts, Side Effects And Dosing, Indocap

indomethacin, Indocin, Indocin-SR (Discontinued Brand in U. S.)

GENERIC NAME: indomethacin

BRAND NAME: Indocin, Indocin-SR (Discontinued Brand in U. S.)

DRUG CLASS AND MECHANISM: Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever. pain and inflammation. It is similar to ibuprofen (Motrin ) and naproxen (Naprosyn. Aleve ). Indomethacin works by reducing the production of prostaglandins. Prostaglandins are chemicals that the body produces and which cause the fever and pain that are associated with inflammation. Indomethacin blocks the enzymes that make prostaglandins (cyclooxygenase 1 and 2) and thereby reduces the levels of prostaglandins. As a result, fever, pain and inflammation are reduced. Indomethacin is available in an extended release form. The FDA first approved indomethacin in January 1965.

PRESCRIBED FOR: Indomethacin is used for the treatment of inflammation caused by rheumatoid arthritis. ankylosing spondylitis. gouty arthritis. osteoarthritis. and soft tissue injuries such as tendinitis and bursitis .

SIDE EFFECTS . Common side effects of indomethacin are:

Medically Reviewed by a Doctor on 12/26/2014

Quick Guide Rheumatoid Arthritis Symptoms and Treatment

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Ezentius Para Que Sirve, E-Zentius

EZENTIUS

PROPIEDADES FARMACOLOGICAS

ACCIÓN FARMACOLÓGICA: E-ZENTIUS es un antidepresivo que actúa por inhibición potente y selectiva de la recaptación de serotonina a nivel central. El escitalopran es el enantiómero S del citalopram racémico y ha demostrado ser cien veces más potente que el enantiómero R. Se ha demostrado que carece o tiene muy poca afinidad por los receptores de la serotonina, los receptores alfa y beta adrenérgicos, dopaminérgicos, histaminérgicos, muscarínicos y benzodiazepínicos. Tampoco se une ni tiene afinidad por los canales celulares de sodio, potasio, cloro y calcio. Farmacocinética: La absorción de escitalopram por vía oral es casi completa y no es alterada por los alimentos. La concentración plasmática máxima se alcanza a las 5 horas. La vida media terminal es de alrededor de 27 a 32 horas y la unión a las proteínas plasmáticas es de 56%. Con la administración de escitalopram una vez al día se logra la concentración plasmática de equilibrio en aproximadamente 7 días de tratamiento, siendo ésta alrededor del doble de la observada después de una dosis única. La eliminación se realiza principalmente por metabolismo hepático a través de las isoenzimas CYP3A4 y CYP2C19, siendo los metabolitos principales el sdemetilcitalopram y el sdidemetilcitalopram, con poca o nula actividad farmacológica. En los pacientes ancianos se ha informado un aumento del área bajo la curva de concentración plasmática/ tiempo (AUC) y de la vida media. Por tal motivo, en estos pacientes la dosis diaria recomendada de escitalopram es de 10 mg. En la insuficiencia hepática se ha observado una disminución de la eliminación con aumento de la vida media del citalopram racémico. Por lo tanto, en estos pacientes la dosis diaria recomendada de escitalopram es de 10 mg. En la insuficiencia renal leve a moderada no es necesario modificar la dosis. No existen datos farmacocinéticos en pacientes con insuficiencia renal severa (clearance de creatinina >= mayor significancia clínica). Riesgo/beneficio debe ser considerado si existen los siguientes problemas medicos: Alteración del metabolismo o de la respuesta hemodinámica (se debe tener cuidado en pacientes con patologías o condiciones médicas que produzcan alteración del metabolismo o de la respuesta hemodinámica). Abuso de drogas, historia de (pacientes con historia previa de abuso de drogas deben ser supervisados muy estrechamente para observar signos de uso incorrecto o abuso de este fármaco, como el desarrollo de tolerancia, incremento de la dosis, y /o ansiedad por el medicamento). . Hepática, insuficiencia (la depuración del citalopram racemico disminuye y la concentración plasmática se incrementa. La dosis recomendada de escritalopram en pacientes con insuficiencia hepática es de 10mg por día). . Manía o hipomanía, historia de (esta condición médica puede ser activada por el escritalopram. Debe ser utilizado con cuidado en pacientes con historia de manía o hipomanía). . Insuficiencia renal, severa (hasta que un número significativo de pacientes con insuficiencia renal severa (depuración de creatinina

PRECAUCIONES Y ADVERTENCIAS ESPECIALES

ADVERTENCIAS: Se han informado interacciones graves con el uso simultáneo de otros inhibidores de la recaptación de serotonina e inhibidores de la MAO (ver Contraindicaciones). En los adultos que utilizan antidepresivos, particularmente aquellos que reciben tratamiento para la depresión, se debe prestar atención si aparece o se incrementa tanto el pensamiento como comportamiento suicida. Esta observación es muy importante para instalar un tratamiento temprano, o realizar cambios y/o ajustes en la dosificación. Si se observan estas manifestaciones, el paciente debe ser inmediatamente evaluado por el médico tratante. Estos antidepresivos no deben de utilizarse en niños y adolescentes, excepto en las indicaciones terapéuticas específicamente autorizadas en dicho grupo de pacientes. PRECAUCIONES El riesgo de intento de suicidio es inherente a la depresión y, como sucede con todos los antidepresivos, puede persistir en las etapas iniciales del tratamiento. Se supervisará estrechamente a los pacientes con riesgo elevado durante las fases iniciales del tratamiento. Existen antecedentes de hiponatremia o síndrome de secreción inapropiada de hormona antidiurética con la administración de escitalopram, citalopram racémico y otras drogas eficaces en el tratamiento de la depresión. En general, estos casos responden a la interrupción de la administración del medicamento y/o al tratamiento médico. Como sucede con todos los antidepresivos, E-ZENTIUS debe administrarse con precaución a los pacientes con antecedentes de manía. E-ZENTIUS se administrará con precaución a los pacientes con antecedentes de epilepsia o convulsiones. Aunque no se han informado interacciones entre el citalopram y el alcohol, como sucede con todos los medicamentos psicotrópicos, se evitará el consumo de bebidas alcohólicas durante el tratamiento con E-ZENTIUS. Tal como es habitual en toda administración de drogas que actúan sobre el Sistema Nervioso Central, quienes reciban E-ZENTIUS deben evitar la conducción de vehículos y la operación de maquinarias peligrosas, hasta tener la certeza de que el medicamento no afecta la habilidad para llevar a cabo esas actividades. No existe suficiente experiencia acerca del tratamiento con escitalopram en pacientes con ciertas enfermedades. E-ZENTIUS se administrará con precaución a los pacientes con enfermedades que alteren el metabolismo o la hemodinamia o que presenten antecedentes recientes de infarto de miocardio o de enfermedad cardíaca inestable. Como el escitalopram es el isómero activo del citalopram racémico, estas drogas no deben administrarse concomitantemente. Embarazo: Aunque los estudios toxicológicos preclínicos no han evidenciado efectos teratogénicos, no existe experiencia suficiente con escitalopram ni con citalopram racémico en mujeres embarazadas. Por lo tanto, E-ZENTIUS sólo debería ser administrado durante el embarazo cuando, después de una cuidadosa evaluación por parte del médico, los beneficios potenciales para la madre justifiquen los riesgos potenciales para la gestación. Lactancia: El citalopram racémico se excreta en la leche. Luego de haber evaluado la relación riesgo/beneficio de la utilización de E-ZENTIUS durante la lactancia y si su indicación se juzgara beneficiosa para la madre, deberá considerarse la discontinuación de la lactancia. Uso pediátrico: No se dispone de estudios sobre la seguridad del escitalopram en niños, por lo tanto su uso está contraindicado en ellos. Uso geriátrico: La vida media puede estar aumentada y los valores de clearance del escitalopram pueden estar disminuidos. La dosis de E-ZENTIUS en los ancianos es de 10 mg/día.

EFECTOS ADVERSOS

REACCIONES ADVERSAS Se ha informado que alrededor de un 6% de los pacientes ha interrumpido el tratamiento por la aparición de reacciones adversas, siendo la interrupción significativamente más frecuente entre los pacientes tratados con las dosis más altas (20 mg/día). Las reacciones adversas más frecuentes (2% o más) fueron: náuseas, insomnio, trastornos de la eyaculación (principalmente retraso), diarrea, sequedad bucal, somnolencia, aumento de la sudoración, vértigo, síndrome gripal, fatiga, rinitis, constipación, trastornos digestivos, disminución del apetito, disminución de la libido, impotencia, dolor abdominal, anorgasmia. No se han informado cambios en los signos vitales, trastornos ortostáticos, modificación del peso corporal, ni cambios clínicamente importantes en los datos de laboratorio durante el tratamiento con escitalopram. Excepto una leve disminución de la frecuencia cardíaca y un leve aumento del intervalo QTc, no se han informado cambios clínicamente significativos en el electrocardiograma con escitalopram ni con citalopram racémico. A continuación se mencionan las reacciones adversas informadas en por lo menos un 1% de los pacientes tratados con escitalopram, aunque la reacción no fuera necesariamente causada por la droga: Cardiovasculares: Palpitaciones, hipertensión. Neurológicas: Parestesias, embotamiento, migraña, temblor, vértigo. Gastrointestinales: Vómitos, flatulencia, pirosis, odontalgia, gastroenteritis, cólicos abdominales, reflujo gastroesofágico. Generales: Alergia, dolor en las extremidades, tuforadas, fiebre, dolor torácico. Metabólicas y nutricionales: Aumento de peso, disminución de peso. Osteomusculares: Artralgia, dolor cervical o dorsal, calambres musculares, mialgia. Psiquiátricas: Sueños anormales, bostezos, aumento del apetito, letargo, irritabilidad, alteración de la concentración. Ginecológicas: Cólicos menstruales. Respiratorias: Bronquitis, congestión sinusal, tos, dolor sinusal, congestión nasal. Dermatológicas: Rash. Sensoriales: Visión borrosa, otalgia, tinnitus. Urológicas: Infección urinaria, aumento de la frecuencia urinaria.

INTERACCIONES MEDICAMENTOSAS

Alcohol: Aunque se ha demostrado en la clínica que el citalopram racémico no aumenta los efectos del alcohol, como sucede con todos los medicamentos psicotrópicos, se evitará el consumo de bebidas alcohólicas durante el tratamiento con E-ZENTIUS. Drogas con acción sobre el SNC: E-ZENTIUS debe administrarse con precaución a pacientes que se encuentren en tratamiento con otras drogas que actúen sobre el SNC. Inhibidores de la monoaminooxidasa (IMAO): La administración concomitante de otros antidepresivos inhibidores de la recaptación de serotonina e IMAO ha dado lugar a reacciones adversas graves (síndrome serotoninérgico). Ver Contraindicaciones y Advertencias. Litio: Se recomienda controlar la concentración plasmática de litio y efectuar los ajustes necesarios. El litio puede aumentar el efecto serotoninérgico del escitalopram, por lo tanto se recomienda precaución cuando se los administre concomitantemente. Digoxina: La administración simultánea de citalopram racémico y digoxina no afectó la farmacocinética de ninguna de las dos drogas. Carbamazepina: Teniendo en cuenta la propiedad inductora enzimática de la carbamazepina sobre el citocromo P450 3A4 (del cual el escitalopram es substrato) se debe tener en cuenta la posibilidad de aumento del clearance de escitalopram con disminución de la concentración plasmática y la vida media, cuando ambas drogas son administradas simultaneamente. Sumatriptán: Se recomienda control clínico pues se han informado raros casos de debilidad, hiperreflexia e incoordinación con el uso simultáneo de inhibidores de la recaptación de serotonina y sumatriptán. Teofilina: No se observó alteración de la farmacocinética de la teofilina cuando se la administró concomitantemente con citalopram racémico. Warfarina: La administración de citalopram racémico no modificó la farmacocinética de la warfarina (sustrato CYP3A4), aunque se observó un aumento del 5% del tiempo de protrombina, sin conocerse su significación clínica. Triazolam: La adminstración simultánea de esta droga (sustrato CYP3A4) con citalopram racémico no alteró la farmacocinética de ninguna de la dos drogas. Ketoconazol: La asociación de citalopram racémico y ketoconazol disminuyó la concentración plasmática máxima y la AUC del ketoconazol y no alteró la cinética del citalopram. Ritonavir: La adminstración conjunta de este inhibidor y sustrato del CYP3A4 y escitalopram, no afectó la farmacocinética de ninguna de las dos drogas. Inhibidores de los CYP 3A4 y 2C19: El escitalopram es primariamente substrato de las isoenzimas 3A4 y 2C19 del citocromo P450. Sin embargo, teniendo en cuenta los resultados observados con el ritonavir y considerando que en el metabolismo del escitalopram intervienen múltiples sistemas enzimáticos, la inhibición de una enzima aislada no debería alterar significativamente la depuración del escitalopram. Drogas metabolizadas por el CYP2D6: Se ha informado que los estudios in vitro no mostraron efecto inhibidor del escitalopram sobre el CYP2D6. Sin embargo, se han informado aumentos significativos de la concentración plasmática máxima y la AUC del antidepresivo tricíclico desipramina (sustrato del CYP2D6). Por este motivo se recomienda precaución cuando se administre escitalopram simultaneamente con drogas metabolizadas por el CYP2D6. Cimetidina: En sujetos que han recibido tratamiento con citalopram racémico conjuntamente con cimetidina se han observado aumentos del área bajo la curva (AUC) y de la concentración plasmática máxima (Cmáx.) del citalopram. Se desconoce la significación clínica de estos hallazgos. Metoprolol: La administración concomitante de escitalopram y metoprolol resultó en un aumento de la concentración plasmática máxima y del AUC del betabloqueante. Esta interacción puede disminuir la cardioselectividad de metoprolol. No se observaron efectos sobre la presión arterial ni sobre la frecuencia cardíaca. Terapia electroconvulsiva: No existen estudios clínicos del tratamiento conjunto con escitalopram y terapia electroconvulsiva.

SOBREDOSIFICACION

Se han informado tres casos de sobredosis de hasta 600 mg de escitalopram, sin informarse síntomas específicos y con recuperación completa. Los síntomas más frecuentemente informados tras la sobredosis de citalopram racémico, sólo o asociado con otras drogas y/o alcohol fueron: vértigo, sudoración, náuseas, vómitos, temblor, somnolencia, taquicardia sinusal y convulsiones. Más raramente se han informado: amnesia, confusión, coma, hiperventilación, cianosis, rabdomiólisis, cambios en el ECG (incluyendo prolongación del intervalo QTc, ritmo nodal, arritmia ventricular y un caso de posible torsión de las puntas). No existen antídotos específicos. La diuresis forzada, la diálisis y la hemoperfusión no resultan eficaces debido al elevado volumen de distribución del escitalopram. Establecer y mantener una adecuada ventilación y oxigenación. Considerar la conveniencia de realizar lavado gástrico y administración de carbón activado. Efectuar control clínico cuidadoso con monitoreo de los signos vitales y cardíacos y tratamiento sintomático y de soporte. Considerar la posibilidad de sobredosis de varias drogas. Ante la eventualidad de una sobredosificación, concurrir al hospital más cercano o comunicarse con los Centros de Toxicología.

Como tomar Y POSOLOGIA

POSOLOGÍA Y FORMA DE ADMINISTRACIÓN La posología de E-ZENTIUS deberá adaptarse a cada caso en particular. Adultos. Dosis inicial: 10 mg una vez por día. Si es necesario, se puede aumentar la dosis a 20 mg por día, después de un mínimo de una semana de tratamiento. . Dosis de mantenimiento: El tratamiento de la depresión requiere continuar con la terapia farmacológica durante varios meses o más, después de obtener la respuesta del episodio agudo. Se recomienda evaluar periódicamente al paciente para determinar la necesidad de la continuación del tratamiento de mantenimiento y la dosis necesaria para el mismo. E-ZENTIUS debe administrarse una vez por día, a la mañana o a la noche, con las comidas o fuera de ellas. En los pacientes ancianos o con insuficiencia hepática la dosis recomendada es de 10 mg por día. En los pacientes con insuficiencia renal leve a moderada no es necesario ajustar la dosis. E-ZENTIUS debe administrarse con precaución a los pacientes con insuficiencia renal severa. . Dosis mínimas y máximas: La dosis mínima de E-ZENTIUS es de 5 mg por día y la dosis máxima es de 20 mg por día.

PRESENTACION

E-ZENTIUS 10 mg: Envases conteniendo 14 y 28 comprimidos recubiertos. E-ZENTIUS 20 mg: Envases conteniendo 14 y 28 comprimidos recubiertos. Producto medicinal. Manténgase fuera del alcance de los niños. Conservar a 25 ?C variación permitida entre 15 y 30 ?C. Expendio bajo receta médica. Elaborado por H. Lundbeck A/S Dinamarca Acondicionado en ROEMMERS S. A. Montevideo, Uruguay LABORATORIOS ROEMMERS S. A. Jr. Faustino Sánchez Carrión 425, Magdalena del Mar, Telf: 462-1616 Lima 17-Perú

ELECTROCARDIOGRAMA . Constituye una util ayuda para el diagnostico o para excluir la posibilidad que un dolor en el pecho tenga su origen en un ataque cardiaco.

INFARTO DE MIOCARDIO . Es el nombre cientifico del ataque al corazon. Se debe a la obstruccion del riego sanguineo (trombosis) en parte de musculo (mio) del corazon(cardio), que produce su destruccion (infarto).

Opiniones

Unicontin-E Tablet Modi-Mundi Pharma Use, Composition, Dosage, Side Effect, Price And Review - Table

Unicontin-E

Unicontin-E Tablet - Uses, Composition, Dosage, Side Effects & Reviews

Asthma is a chronic inflammatory disease portrayed by airflow obstruction and bronchial hyper-reactivity. Most of asthma symptoms result from airflow obstruction caused by airway lumen narrowing. Unicontin-E is used for the prevention and treatment of bronchial smooth muscle constriction in patients with asthma and chronic bronchitis. This drug work in two ways that are smooth muscle relaxation and suppression of the response of the airways to stimuli. The constriction of the airways in the lungs occurs due to the tightening of surrounding smooth muscle with consequent wheezing, coughing and shortness of breath.

Get the benefits from the Unicontin-E tablet. It is available online at low price at the Tablet Tree.

Unicontin-E Tablet Uses

Theophylline belongs to a drug class called xanthines. It works in the airways by relaxing muscles, opening air passages to improve breathing, and decreasing the lung's response to irritants.

Unicontin-E Tablet Composition

Each Unicontin-E 400 tablet contains:

Theophylline………. 400 mg

Each Unicontin-E 600 tablet contains:

Theophylline………. 600 mg

Unicontin-E Tablet Dosage

The starting dosage for children < 45 kg is 12-14 mg/kg/day up to a maximum of 300 mg/day administered once daily.

The starting dosage for children > 45 kg and adults is 300-400 mg/day administered once daily.

Please consult your doctor and follow his or her recommendations. Please do not self medicate.

Unicontin-E Tablet Side Effects

Unicontin-E can cause following side effects:

Nausea, vomiting, headache, insomnia, diarrhoea, irritability, restlessness, palpitations, hypotension, fine skeletal muscle tremors, tachypnea

Pharmaceutical Form

Precautions

Do not use machinery or drive a vehicle that requires alertness

While taking this drug, if you develop a fever/flu-like symptoms then you should tell your doctor

Do not drink or eat foods that have high in caffeine, like coffee, tea, cocoa, and chocolate, because it may increase the side effects

Do not take this drug if you are allergic to theophylline or its other ingredients

Consult your doctor before starting this drug if you are pregnant, planning to have pregnant or are breast-feeding

Drug–Drug Interaction

Unicontin-E interact with the following given drugs:

Adenosine, Allopurinol, Diazepam, Enoxacin, Estrogen, Lithium containing drugs, Lorazepam, Tacrine, Verapamil, Erythromycin, Fluvoxamine

Contraindications

This drug is contraindicated in the following conditions:

History of hypersensitivity of this drug or its components

Patients with porphyria

Package content

Each strip of Unicontin-E 400 contains 10 tablets

Each strip of Unicontin-E 600 contains 10 tablets

Manufacturer

Modi Mundi Pharma

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Prochlorperazine - Fda Prescribing Information, Side Effects And Uses, Prochlorperazin

Prochlorperazine

Increased Mortality in Elderly Patients with Dementia-Related Psychosis

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e. g. heart failure, sudden death) or infectious (e. g. pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. Prochlorperazine Edisylate Injection, USP is not approved for the treatment of patients with dementia-related psychosis (see WARNINGS ).

Prochlorperazine Description

Prochlorperazine edisylate, 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine 1,2-ethanedisulfonate (1:1), has the following structural formula:

C 20 H 24 ClN 3 S C 2 H 6 O 6 S 2 MW 564.14

Prochlorperazine Edisylate Injection, an antiemetic and antipsychotic, is a sterile solution intended for intramuscular or intravenous administration.

Each mL contains Prochlorperazine 5 mg as the edisylate, monobasic sodium phosphate monohydrate 5 mg, sodium tartrate dihydrate 12 mg, saccharin sodium 0.9 mg and benzyl alcohol 7.5 mg in Water for Injection. pH 4.2-6.2.

Prochlorperazine - Clinical Pharmacology

Prochlorperazine is a propylpiperazine derivative of phenothiazine. Like other phenothiazines, it exerts an antiemetic effect through a depressant action on the chemoreceptor trigger zone. It also has a clinically useful antipsychotic effect. Following intramuscular administration of Prochlorperazine edisylate, the drug has an onset of action within ten to twenty minutes and a duration of action of three to four hours.

Indications and Usage for Prochlorperazine

To control severe nausea and vomiting. For the treatment of schizophrenia.

Prochlorperazine has not been shown effective in the management of behavioral complications in patients with mental retardation.

Contraindications

Do not use in patients with known hypersensitivity to phenothiazines.

Do not use in comatose states or in the presence of large amounts of central nervous system depressants (alcohol, barbiturates, narcotics, etc.).

Do not use in pediatric surgery.

Do not use in pediatric patients under 2 years of age or under 20 lbs. Do not use in children for conditions for which dosage has not been established.

Warnings

Increased Mortality in Elderly Patients with Dementia-Related Psychosis

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Prochlorperazine Edisylate Injection, USP is not approved for the treatment of patients with dementia-related psychosis (see BOXED WARNING ).

The extrapyramidal symptoms which can occur secondary to Prochlorperazine may be confused with the central nervous system signs of an undiagnosed primary disease responsible for the vomiting, e. g. Reye's syndrome or other encephalopathy. The use of Prochlorperazine and other potential hepatotoxins should be avoided in children and adolescents whose signs and symptoms suggest Reye's syndrome.

Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with antipsychotic drugs. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic drug treatment, which patients are likely to develop the syndrome. Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown.

Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase. However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses.

There is no known treatment for established cases of tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic drug treatment is withdrawn. Antipsychotic drug treatment, itself, however, may suppress (or partially suppress) the signs and symptoms of the syndrome and thereby may possibly mask the underlying disease process. The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown.

Given these considerations, antipsychotic drugs should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia. Chronic antipsychotic treatment should generally be reserved for patients who suffer from a chronic illness that, 1) is known to respond to antipsychotic drugs, and, 2) for whom alternative, equally effective, but potentially less harmful treatments are not available or appropriate. In patients who do require chronic treatment, the smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be sought. The need for continued treatment should be reassessed periodically.

If signs and symptoms of tardive dyskinesia appear in a patient on antipsychotics, drug discontinuation should be considered. However, some patients may require treatment despite the presence of the syndrome.

For further information about the description of tardive dyskinesia and its clinical detection, please refer to the sections on PRECAUTIONS and ADVERSE REACTIONS .

Neuroleptic Malignant Syndrome (NMS)

A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias).

The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (e. g. pneumonia, systemic infection, etc.) and untreated or inadequately treated extrapyramidal signs and symptoms (EPS).Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system (CNS) pathology.

The management of NMS should include 1) immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy, 2) intensive symptomatic treatment and medical monitoring and 3) treatment of any concomitant serious medical problems for which specific treatments are available. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS.

If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered. The patient should be carefully monitored, since recurrences of NMS have been reported.

An encephalopathic syndrome (characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN and FBS) has occurred in a few patients treated with lithium plus an antipsychotic. In some instances, the syndrome was followed by irreversible brain damage. Because of a possible causal relationship between these events and the concomitant administration of lithium and antipsychotics, patients receiving such combined therapy should be monitored closely for early evidence of neurologic toxicity and treatment discontinued promptly if such signs appear. This encephalopathic syndrome may be similar to or the same as neuroleptic malignant syndrome (NMS).

Patients with bone marrow depression or who have previously demonstrated a hypersensitivity reaction (e. g. blood dyscrasias, jaundice) with a phenothiazine should not receive any phenothiazine, including Prochlorperazine, unless in the judgment of the physician the potential benefits of treatment outweigh the possible hazards.

Prochlorperazine may impair mental and/or physical abilities, especially during the first few days of therapy. Therefore, caution patients about activities requiring alertness (e. g. operating vehicles or machinery).

Phenothiazines may intensify or prolong the action of central nervous system depressants (e. g. alcohol, anesthetics, narcotics).

Neonates exposed to antipsychotic drugs, during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery. There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress and feeding disorder in these neonates. These complications have varied in severity; while in some cases symptoms have been self-limited, in other cases neonates have required intensive care unit support and prolonged hospitalization.

Prochlorperazine Edisylate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Usage in Pregnancy

Safety for the use of Prochlorperazine during pregnancy has not been established. Therefore, Prochlorperazine is not recommended for use in pregnant patients except in cases of severe nausea and vomiting that are so serious and intractable that, in the judgment of the physician, drug intervention is required and potential benefits outweigh possible hazards.

There have been reported instances of prolonged jaundice, extrapyramidal signs, hyperreflexia or hyporeflexia in newborn infants whose mothers received phenothiazines.

There is evidence that phenothiazines are excreted in the breast milk of nursing mothers. Caution should be exercised when Prochlorperazine is administered to a nursing woman.

Precautions

Leukopenia, Neutropenia and Agranulocytosis

In clinical trial and postmarketing experience, events of leukopenia/neutropenia and agranulocytosis have been reported temporally related to antipsychotic agents.

Possible risk factors for leukopenia/neutropenia include preexisting low white blood cell count (WBC) and history of drug induced leukopenia/neutropenia. Patients with a preexisting low WBC or a history of drug induced leukopenia/neutropenia should have their complete blood count (CBC) monitored frequently during the first few months of therapy and should discontinue Prochlorperazine Edisylate Injection USP at the first sign of a decline in WBC in the absence of other causative factors.

Patients with neutropenia should be carefully monitored for fever or other symptoms or signs of infection and treated promptly if such symptoms or signs occur. Patients with severe neutropenia (absolute neutrophil count <1000/mm 3 ) should discontinue Prochlorperazine Edisylate Injection USP and have their WBC followed until recovery.

Prochlorperazine's antiemetic action may mask signs and symptoms of overdosage of other drugs and may obscure the diagnosis and treatment of other conditions such as intestinal obstruction, brain tumor and Reye's syndrome (see WARNINGS ).

When Prochlorperazine is used with cancer chemotherapeutic drugs, vomiting as a sign of toxicity of these agents may be obscured by the antiemetic effect of Prochlorperazine.

Because hypotension may occur, large doses and parenteral administration should be used cautiously in patients with impaired cardiovascular systems. To minimize the occurrence of hypotension after injection, keep patient lying down and observe for at least 1/2 hour. If hypotension occurs after parenteral dosing, place patient in head-low position with legs raised. If a vasoconstrictor is required, norepinephrine and phenylephrine are suitable. Other pressor agents, including epinephrine, should not be used because they may cause a paradoxical further lowering of blood pressure.

Aspiration of vomitus has occurred in a few postsurgical patients who have received Prochlorperazine as an antiemetic. Although no causal relationship has been established, this possibility should be borne in mind during surgical aftercare.

Deep sleep, from which patients can be aroused, and coma have been reported, usually with overdosage.

Antipsychotic drugs elevate prolactin levels; the elevation persists during chronic administration. Tissue culture experiments indicate that approximately one-third of human breast cancers are prolactin-dependent in vitro, a factor of potential importance if the prescription of these drugs is contemplated in a patient with a previously detected breast cancer. Although disturbances such as galactorrhea, amenorrhea, gynecomastia, and impotence have been reported, the clinical significance of elevated serum prolactin levels is unknown for most patients. An increase in mammary neoplasms has been found in rodents after chronic administration of antipsychotic drugs. Neither clinical studies nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is considered too limited to be conclusive at this time.

Chromosomal aberrations in spermatocytes and abnormal sperm have been demonstrated in rodents tested with certain antipsychotics.

As with all drugs which exert an anticholinergic effect, and/or cause mydriasis, Prochlorperazine should be used with caution in patients with glaucoma.

Because phenothiazines may interfere with thermoregulatory mechanisms, use with caution in persons who will be exposed to extreme heat.

Phenothiazines can diminish the effect of oral anticoagulants.

Phenothiazines can produce alpha-adrenergic blockade.

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines.

Antihypertensive effects of guanethidine and related compounds may be counteracted when phenothiazines are used concomitantly.

Concomitant administration of propranolol with phenothiazines results in increased plasma levels of both drugs.

Phenothiazines may lower the convulsive threshold; dosage adjustments of anticonvulsants may be necessary. Potentiation of anticonvulsant effects does not occur.

However, it has been reported that phenothiazines may interfere with the metabolism of phenytoin and thus precipitate phenytoin toxicity.

The presence of phenothiazines may produce false-positive phenylketonuria (PKU) test results.

Given the likelihood that some patients exposed chronically to antipsychotics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk. The decision to inform patients and/or their guardians must obviously take into account the clinical circumstances and the competency of the patient to understand the information provided.

To lessen the likelihood of adverse reactions related to cumulative drug effect, patients with a history of long-term therapy with Prochlorperazine and/or other antipsychotics should be evaluated periodically to decide whether the maintenance dosage could be lowered or drug therapy discontinued.

Children with acute illnesses (e. g. chickenpox, CNS infections, measles, gastroenteritis) or dehydration seem to be much more susceptible to neuromuscular reactions, particularly dystonias, than are adults. In such patients, the drug should be used only under close supervision.

Drugs which lower the seizure threshold, including phenothiazine derivatives, should not be used with metrizamide. As with other phenothiazine derivatives, Prochlorperazine should be discontinued at least 48 hours before myelography, should not be resumed for at least 24 hours postprocedure, and should not be used for the control of nausea and vomiting occurring either prior to myelography with metrizamide or postprocedure.

Adverse Reactions

Drowsiness, dizziness, amenorrhea, blurred vision, skin reactions and hypotension may occur. Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs (see WARNINGS ).

Cholestatic jaundice has occurred. If fever with grippe-like symptoms occurs, appropriate liver studies should be conducted. If tests indicate an abnormality, stop treatment. There have been a few observations of fatty changes in the livers of patients who have died while receiving the drug. No causal relationship has been established.

Leukopenia and agranulocytosis have occurred. Warn patients to report the sudden appearance of sore throat or other signs of infection. If white blood cell and differential counts indicate leukocyte depression, stop treatment and start antibiotic and other suitable therapy.

Neuromuscular (Extrapyramidal) Reactions

These symptoms are seen in a significant number of hospitalized mental patients. They may be characterized by motor restlessness, be of the dystonic type, or they may resemble parkinsonism.

Depending on the severity of symptoms, dosage should be reduced or discontinued. If therapy is reinstituted, it should be at a lower dosage. Should these symptoms occur in children or pregnant patients, the drug should be stopped and not reinstituted. In most cases barbiturates by suitable route of administration will suffice, or injectable diphenhydramine may be useful.

In more severe cases, the administration of an antiparkinsonism agent, except levodopa, usually produces rapid reversal of symptoms. Suitable supportive measures such as maintaining a clear airway and adequate hydration should be employed.

Motor Restlessness

Symptoms may include agitation or jitteriness and sometimes insomnia. These symptoms often disappear spontaneously. At times these symptoms may be similar to the original neurotic or psychotic symptoms. Dosage should not be increased until these side effects have subsided.

If these symptoms become too troublesome, they can usually be controlled by a reduction of dosage or change of drug. Treatment with antiparkinsonian agents, benzodiazepines or propranolol may be helpful.

Dystonia

Class effect. Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue. While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. An elevated risk of acute dystonia is observed in males and younger age groups.

Pseudoparkinsonism

Symptoms may include mask-like facies, drooling, tremors, pillrolling motion, cogwheel rigidity, and shuffling gait. Reassurance and sedation are important. In most cases, these symptoms are readily controlled when an antiparkinsonism agent is administered concomitantly. Antiparkinsonism agents should be used only when required. Generally, therapy of a few weeks to two or three months will suffice. After this time, patients should be evaluated to determine their need for continued treatment. (Note: Levodopa has not been found effective in pseudoparkinsonism.) Occasionally, it is necessary to lower the dosage of Prochlorperazine or to discontinue the drug.

Tardive Dyskinesia

As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or may appear after drug therapy has been discontinued. The syndrome can also develop, although much less frequently, after relatively brief treatment periods at low doses. This syndrome appears in all age groups. Although its prevalence appears to be highest among elderly patients, especially elderly women, it is impossible to rely upon prevalence estimates to predict at the inception of antipsychotic treatment which patients are likely to develop the syndrome. The symptoms are persistent and in some patients appear to be irreversible. The syndrome is characterized by rhythmical involuntary movements of the tongue, face, mouth or jaw (e. g. protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements). Sometimes these may be accompanied by involuntary movements of extremities. In rare instances, these involuntary movements of the extremities are the only manifestations of tardive dyskinesia. A variant of tardive dyskinesia, tardive dystonia, has also been described.

There is no known effective treatment for tardive dyskinesia; antiparkinsonism agents do not alleviate the symptoms of this syndrome. It is suggested that all antipsychotic agents be discontinued if these symptoms appear. Should it be necessary to reinstitute treatment or increase the dosage of the agent or switch to a different antipsychotic agent, the syndrome may be masked.

It has been reported that fine vermicular movements of the tongue may be an early sign of the syndrome, and if the medication is stopped at that time, the syndrome may not develop.

Contact Dermatitis

Avoid getting the injection solution on hands or clothing because of the possibility of contact dermatitis.

Adverse Reactions Reported with Prochlorperazine or Other Phenothiazine Derivatives

Adverse reactions with different phenothiazines vary in type, frequency, and the mechanism of occurrence, i. e. some are dose-related, while others involve individual patient sensitivity.

Some adverse reactions may be more likely to occur, or occur with greater intensity, in patients with special medical problems, e. g. patients with mitral insufficiency or pheochromocytoma have experienced severe hypotension following recommended doses of certain phenothiazines.

Not all of the following adverse reactions have been observed with every phenothiazine derivative but they have been reported with one or more and should be borne in mind when drugs of this class are administered: extrapyramidal symptoms (opisthotonos, oculogyric crisis, hyperreflexia, dystonias, akathisia, dyskinesia, parkinsonism), some of which have lasted months and even years, particularly in elderly patients with previous brain damage; grand mal and petit mal convulsions, particularly in patients with EEG abnormalities or history of such disorders; altered cerebrospinal fluid proteins; cerebral edema; intensification and prolongation of the action of central nervous system depressants (opiates, analgesics, antihistamines, barbiturates, alcohol), atropine, heat, organophosphorus insecticides; autonomic reactions (dryness of mouth, nasal congestion, headache, nausea, constipation, obstipation, adynamic ileus, ejaculatory disorders/impotence, priapism, atonic colon, urinary retention, miosis and mydriasis); reactivation of psychotic processes, catatonic-like states; hypotension (sometimes fatal); cardiac arrest; blood dyscrasias (pancytopenia, thrombocytopenic purpura, leukopenia, agranulocytosis, eosinophilia, hemolytic anemia, aplastic anemia); liver damage (jaundice, biliary stasis); endocrine disturbances (hyperglycemia, hypoglycemia, glycosuria, lactation, galactorrhea, gynecomastia, menstrual irregularities, false-positive pregnancy tests); skin disorders (photosensitivity, itching, erythema, urticaria, eczema up to exfoliative dermatitis); other allergic reactions (asthma, laryngeal edema, angioneurotic edema, anaphylactoid reactions); peripheral edema; reversed epinephrine effect; hyperpyrexia; mild fever after large IM doses; increased appetite; increased weight; a systemic lupus erythematosus-like syndrome; pigmentary retinopathy; with prolonged administration of substantial doses, skin pigmentation, epithelial keratopathy, and lenticular and corneal deposits.

EKG changes—particularly nonspecific, usually reversible Q - and T-wave distortions—have been observed in some patients receiving phenothiazines.

Although phenothiazines cause neither psychic nor physical dependence, sudden discontinuation in long-term psychiatric patients may cause temporary symptoms, e. g. nausea and vomiting, dizziness, tremulousness.

NOTE: There have been occasional reports of sudden death in patients receiving phenothiazines. In some cases, the cause appeared to be cardiac arrest or asphyxia due to failure of the cough reflex.

Overdosage

Primarily involvement of the extrapyramidal mechanism producing some of the dystonic reactions described above. Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever, and autonomic reactions such as hypotension, dry mouth and ileus.

It is important to determine other medications taken by the patient since multiple drug therapy is common in overdosage situations. Treatment is essentially symptomatic and supportive. Keep patient under observation and maintain an open airway, since involvement of the extrapyramidal mechanism may produce dysphagia and respiratory difficulty in severe overdosage.

Extrapyramidal symptoms may be treated with antiparkinsonism drugs, barbiturates, or diphenhydramine. See prescribing information for these products. Care should be taken to avoid increasing respiratory depression.

If administration of a stimulant is desirable, amphetamine, dextroamphetamine, or caffeine and sodium benzoate is recommended. Stimulants that may cause convulsions (e. g. picrotoxin or pentylenetetrazol) should be avoided.

If hypotension occurs, the standard measures for managing circulatory shock should be initiated. If it is desirable to administer a vasoconstrictor, norepinephrine or phenylephrine are most suitable. Other pressor agents, including epinephrine, are not recommended, because phenothiazine derivatives may reverse the usual elevating action of these agents and cause a further lowering of blood pressure.

Limited experience indicates that phenothiazines are not dialyzable.

Prochlorperazine Dosage and Administration

NOTE ON INJECTION: For intramuscular administration, inject deeply into the upper, outer quadrant of the buttock.

Subcutaneous administration is not advisable because of local irritation.

This solution should be protected from light. Slight yellowish discoloration will not alter potency. If markedly discolored, solution should be discarded.

It is recommended that Prochlorperazine Edisylate Injection not be mixed with other agents in the syringe.

(For children's dosage and administration, see below.) Dosage should be increased more gradually in debilitated or emaciated patients.

In general, dosages in the lower range are sufficient for most elderly patients. Since they appear to be more susceptible to hypotension and neuromuscular reactions, such patients should be observed closely. Dosage should be tailored to the individual, response carefully monitored, and dosage adjusted accordingly. Dosage should be increased more gradually in elderly patients.

TO CONTROL SEVERE NAUSEA AND VOMITING

Adjust dosage to the response of the individual. Begin with lowest recommended dosage.

Initially 5 mg to 10 mg (1 to 2 mL) injected deeply into the upper, outer quadrant of the buttock. If necessary, repeat every 3 or 4 hours. Total IM dosage should not exceed 40 mg per day.

2.5 mg to 10 mg (0.5 to 2 mL) by slow IV injection or infusion at a rate not to exceed 5 mg per minute. Prochlorperazine Edisylate Injection may be administered either undiluted or diluted in isotonic solution. A single dose of the drug should not exceed 10 mg; total IV dosage should not exceed 40 mg per day. When administered IV, do not use bolus injection. Hypotension is a possibility if the drug is given by IV injection or infusion.

Subcutaneous administration is not advisable because of local irritation.

ADULT SURGERY (FOR SEVERE NAUSEA AND VOMITING)

Total parenteral dosage should not exceed 40 mg per day. Hypotension is a possibility if the drug is given by IV injection or infusion.

5 mg to 10 mg (1 to 2 mL) 1 to 2 hours before induction of anesthesia (repeat once in 30 minutes, if necessary), or to control acute symptoms during and after surgery (repeat once if necessary).

5 mg to 10 mg (1 to 2 mL) as a slow IV injection or infusion 15 to 30 minutes before induction of anesthesia, or to control acute symptoms during or after surgery. Repeat once if necessary. Prochlorperazine may be administered either undiluted or diluted in isotonic solution, but a single dose of the drug should not exceed 10 mg. The rate of administration should not exceed 5 mg per minute. When administered IV, do not use bolus injection.

IN ADULT PSYCHIATRIC DISORDERS

Adjust dosage to the response of the individual and according to the severity of the condition. Begin with the lowest recommended dose. Although response ordinarily is seen within a day or two, longer treatment is usually required before maximal improvement is seen.

For immediate control of adult schizophrenic patients with severe symptomatology, inject an initial dose of 10 mg to 20 mg (2 to 4 mL) deeply into the upper, outer quadrant of the buttock. Many patients respond shortly after the first injection. If necessary, however, repeat the initial dose every 2 to 4 hours (or, in resistant cases, every hour) to gain control of the patient. More than 3 or 4 doses are seldom necessary. After control is achieved, switch patient to an oral form of the drug at the same dosage level or higher. If, in rare cases, parenteral therapy is needed for a prolonged period, give 10 mg to 20 mg (2 to 4 mL) every 4 to 6 hours. Pain and irritation at the site of injection have seldom occurred.

Subcutaneous administration is not advisable because of local irritation.

DO NOT USE IN PEDIATRIC SURGERY

Children seem more prone to develop extrapyramidal reactions, even on moderate doses. Therefore, use lowest effective dosage. Tell parents not to exceed prescribed dosage, since the possibility of adverse reactions increases as dosage rises.

Occasionally the patient may react to the drug with signs of restlessness and excitement; if this occurs, do not administer additional doses. Take particular precaution in administering the drug to children with acute illnesses or dehydration (see under PRECAUTIONS and Dystonia ).

SEVERE NAUSEA AND VOMITING IN CHILDREN

Prochlorperazine should not be used in pediatric patients under 20 pounds in weight or two years of age. It should not be used in conditions for which children's dosages have not been established. Dosage and frequency of administration should be adjusted according to the severity of the symptoms and the response of the patient. The duration of activity following intramuscular administration may last up to 12 hours. Subsequent doses may be given by the same route if necessary.

Calculate each dose on the basis of 0.06 mg of the drug per lb of body weight; give by deep IM injection. Control is usually obtained with one dose.

CHILDREN WITH SCHIZOPHRENIA

For ages under 12, calculate each dose on the basis of 0.06 mg of Prochlorperazine per lb of body weight; give by deep IM injection. Control is usually obtained with one dose. After control is achieved, switch the patient to an oral form of the drug at the same dosage level or higher.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

How is Prochlorperazine Supplied

Prochlorperazine Edisylate Injection, USP 5 mg/mL is a colorless to slightly yellowish solution.

Prochlorperazine Edisylate Injection, USP is supplied as follows:

NDC 23155- 523 -41

FOR DEEP IM OR IV USE ONLY

NOT FOR SUBCUTANEOUS USE

PROTECT FROM LIGHT: Keep covered in carton until time of use.

Discard contents if markedly discolored.

Each mL contains Prochlorperazine, USP 5 mg as the Edisylate, Monobasic Sodium Phosphate Monohydrate, USP 5 mg, Sodium Tartrate Dihydrate, NF 12 mg, Saccharin Sodium, USP 0.9 mg and Benzyl Alcohol, NF 7.5 mg in Water for Injection, USP. pH 4.2-6.2.

USUAL DOSAGE: See package insert for complete prescribing information for children and adults.

DO NOT USE IN PEDIATRIC SURGERY.

Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].

Manufactured by. Emcure Pharmaceuticals Ltd.

Hinjwadi, Pune, India.

Manufactured for. Heritage Pharmaceuticals Inc.

Eatontown, NJ 07724

PREMIER Pro Rx TM

Arthritis - National Library Of Medicine - Pubmed Health, Artritin

Arthritis

About Arthritis

Arthritis is a general term for conditions that affect the joints and surrounding tissues. Joints are places in the body where bones come together, such as the knees. wrists. fingers. toes, and hips. The two most common types of arthritis are osteoarthritis and rheumatoid arthritis .

Osteoarthritis (OA) is a painful, degenerative joint disease that often involves the hips, knees. neck. lower back, or small joints of the hands. OA usually develops in joints that are injured by repeated overuse from performing a particular task or playing a favorite sport or from carrying around excess body weight.

Eventually this injury or repeated impact thins or wears away the cartilage that cushions the ends of the bones in the joint. As a result, the bones rub together, causing a grating sensation. Joint flexibility is reduced, bony spurs develop, and the joint swells. Usually, the first symptom of OA is pain that worsens following exercise or immobility.

Treatment usually includes analgesics, topical creams, or nonsteroidal anti-inflammatory drugs (known as NSAIDs); appropriate exercises or physical therapy ; joint splinting; or joint replacement surgery for seriously damaged larger joints. such as the knee or hip.

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that usually involves various joints in the fingers. thumbs. wrists. elbows, shoulders. knees. feet, and ankles. An autoimmune disease is one in which the body releases enzymes that attack its own healthy tissues. In RA, these enzymes destroy the linings of joints. This causes pain, swelling, stiffness, malformation, and reduced movement and function.

Although osteoporosis and osteoarthritis are two very different medical conditions with little in common, the similarity of their names causes great confusion. These conditions develop differently, have different symptoms, are diagnosed differently, and are treated differently. NIH - National Institute of Arthritis and Musculoskeletal and Skin Diseases

What works? Research summarized

Evidence reviews

Antimalarials have been used for the treatment of rheumatoid arthritis (RA) for several decades. This review found four trials, with 300 patients receiving hydrochloroquine and 292 receiving placebo. A benefit was observed in the patients taking hydroxychloroquine compared to placebo. There was no difference between the two groups in terms of those who had to withdraw from trials due to side effects.

The purpose was to examine the effectiveness of patient education interventions on health status (pain, functional disability, psychological well?being and disease activity) in patients with rheumatoid arthritis (RA). Patient education had a small beneficial effect at first follow?up for disability, joint counts, patient global assessment, psychological status, and depression. At final follow?up (3?14 months) no evidence of significant benefits was found.

In rheumatoid arthritis (RA), the joints are swollen, stiff and painful. Nonsteroidal anti?inflammatory drugs (NSAIDs) such as ibuprofen are often recommended to ease the pain and swelling in the joints. Paracetamol (also known as acetaminophen) is another type of medication to relieve pain in RA.

Summaries for consumers

Antimalarials have been used for the treatment of rheumatoid arthritis (RA) for several decades. This review found four trials, with 300 patients receiving hydrochloroquine and 292 receiving placebo. A benefit was observed in the patients taking hydroxychloroquine compared to placebo. There was no difference between the two groups in terms of those who had to withdraw from trials due to side effects.

It can be difficult to diagnose rheumatoid arthritis early on in the disease. In the first few weeks and months, the symptoms are often mild and not always typical. But it's still important to try to diagnose and treat rheumatoid arthritis as soon as possible. It is thought that early treatment helps to stop the progression of the disease. Some of the non-specific symptoms include general weakness, exhaustion, tiredness and weight loss. Other early signs include a slight fever, as well as achy bones and muscles. But people might also experience more typical rheumatoid arthritis symptoms such as swollen joints. If you're concerned about non-specific symptoms, you can see a doctor. Tests specifically for rheumatoid arthritis will be recommended at the latest ifthree or more joints have been swollen for at least six weeks, the same joints are swollen on both sides of the body, and/oryour joints feel stiff for at least one hour each morning.

The purpose was to examine the effectiveness of patient education interventions on health status (pain, functional disability, psychological well?being and disease activity) in patients with rheumatoid arthritis (RA). Patient education had a small beneficial effect at first follow?up for disability, joint counts, patient global assessment, psychological status, and depression. At final follow?up (3?14 months) no evidence of significant benefits was found.

Terms to know

Inflammation Redness, swelling, pain, and/or a feeling of heat in an area of the body. This is a protective reaction to injury, disease, or irritation of the tissues. Joints In medicine, the place where two or more bones are connected. Examples include the shoulder, elbow, knee, and jaw. Osteoporosis Literally means "porous bone." This disease is characterized by too little bone formation, excessive bone loss, or a combination of both, leading to bone fragility and an increased risk of fractures of the hip, spine and wrist. Paget Disease A bone disease that causes bones to grow larger and weaker than normal. Rheumatologist Doctors who diagnose and treat diseases of the bones, joints, muscles, and tendons, including arthritis and collagen diseases. Tissue A group of cells that act together to carry out a specific function in the body. Examples include muscle tissue, nervous system tissue (including the brain, spinal cord, and nerves), and connective tissue (including ligaments, tendons, bones, and fat). Organs are made up of tissues.

More about Arthritis

About Apresia, Apresia

About Apresia ? / Skintactix ?

Apresia and Skintactix are part of a larger corporation that develops and produces skin care products for medical and clinical skin care professionals. Under various labels our products are distributed in the USA, Canada, Europe, Asia and Australia.

The Apresia and Skintactix labels and websites were introduced in June of 2001, giving the public easy access to highly effective skin care products and treatment. Information and education have been an emphasis within our corporation since 1997 and we hope this website has been a valuable and complete resource.

Following are photographs and descriptions of our personnel participating in professional skin care activities in various parts of the world.

Left: G. Lockhart (biologist) and T. Compton (educator) participate in an international conference for skin care professionals, where Lockhart was one of several key-note speakers. (Orlando, Florida, October 2002)

Right: S. Tan, M. D. (dermatologist) poses for the camera after a presentation on variations in treating acne on Asian skin at an international conference of dernatology. (Paris, France, March 2001)

Above: A group of medical and paramedical clinicians from Latvia, Lithuania and Poland attends our seminar on the biochemistry of acne and eczema, and methods of control and remission. (Vilnius, Lithuania, September 2004)

Above: At a trade show/conference in the USA medical and aesthetics professionals look for information and more effective forms of treatment. We provide information at our booth as well as educational classrooms. (Las Vegas, Nevada, May 2004)

Apresia / Skintactix 4891-A Ronson Court San Diego, CA 92111 Fax (858)715-0206 Questions should be submitted on the Feedback form . which allows us the opportunity to respond by e-mail as time is available during the day, and reply with written information that is more complete and useful. Because our staff must perform many functions and personnel who answer technical questions may be in other parts of the country or world, we appreciate your cooperation in submitting questions via the Feedback form.

Orders may not be placed by telephone. Our Order Form is completely automated and it eliminates the possibility of errors that can occur with verbal orders. The Order Form is secured for your complete protection.

Apresia and Skintactix comply with local, state and federal regulations pursuant to the manufacture of skin care products. The products are certified by the State of California, Department of Health Services for good manufacturing practices and product sales in the USA and abroad. Apresia and Skintactix do not participate in animal testing and elect not to use any ingredients that may have undesirable side effects.

Apresia ? and Skintactix ? are registered trademarks. The contents of this website are protected by copyright. Some skin care products are patented and patent pending. Any party requiring specific trademark, copyright or patent details may contact our trademark, copyright, patent attorney .

? 2006 Apresia / Skintactix

Diclosulam (145701-21-9), Diclocular

Body Weight Decrease Kidney Liver

CLASS ACTION: 29 Texas peanut farmers argued that during the 2000 growing season Dow's newly marketed fluorinated diclosulam herbicide called Strongarm severely damaged their crops. In their efforts to create a Class Action suit, the farmers lost their case in two courts. They then appealed to the U. S. Supreme Court. On April 27, 2005, the Supreme Court ruled that farmers whose crops are damaged by federally approved pesticides or herbicides may pursue damage claims against the manufacturers in state court.

See FAN's Index to Class Action News Reports and Timeline relating to the Class Action.

Regulatory Information (only comprehensive for the US)

US EPA Registered:

Strongarm herbicide. Application for Emergency Exemption for use on peanut fields in Texas. EPA has received a specific exemption request from the Texas Department of Agriculture to use the new chemical diclosulam (Strongarm Agriculture Herbicide, EPA File Symbol 62719-EII) to treat up to 184,000 acres of peanuts, to control broadleaf weeds. The Applicant proposes the use of a new chemical which has not been registered by the EPA.

DOW ELANCO - Issuance of Experimental Use Permit (62719-EUP-31). This experimental use permit allows the use of 2.67 pounds of the herbicide on 86 acres of soybeans to evaluate the control of broadleaf weeds and sedges. The program is authorized only in the States of AL, AR, GA, KY, LA, MS, MO, NC, SC, TN, and VA. The experimental use permit is effective from July 18, 1995 to March 1, 1997. This permit is issued with the limitation that all treated crops are destroyed or used for research purposes only.

Amarel, Amarel

AMAREL - It means "The Message or Word of God"

NOTE: Brand New Versions - 3-23-16 This is a MAJOR UPDATE

Subsequent books will be posted as they are completed.

Re-Thinking The New Covenant in its entirety is available with a new cover and revised title.

These two volumes add a whole new dimension to the study of Scripture. They’re designed to be read out loud . and at a slower pace than usual to enable you to obtain a far richer experience of the text. A new format causes you to think about what you’re reading. In column notes give you ready access to helpful information.

These versions of Scripture are for “ SEEKERS ” . those who are seriously interested in learning The Truth. If you’re not serious about your study of The Word of YAHWEH then perhaps you’ll find other versions of The Bible of more interest to you. But if you long for The Truth of Scripture you’re invited to begin a fascinating journey into whole new understandings of the text. Scripture For Seekers will be noted by ( S4S Version ).

The ??, aleph-tau . has provided a challenge for many for centuries. Now you can discover why it’ s in the text and what it means . Scholars have debated this issue for a very long time, and have traditionally agreed that it represents a “marker” for the direct-object of a verb. This is absolutely not true! There is a real purpose for its inclusion. Each time it occurs it impacts the text. Find out today how it works.

All the books of The New Covenant are available.

Work has begun on the rest of The Old Covenant books and each book will be posted as it’s completed.

Discover facts you’ve never been taught before.

Dedicated to seeking The Truth. The result of over 50 years of study and reflection. This is the AGE OF DECEPTION . Be very careful about what you accept as “ truth”. _____________________________________________________________________________________

Note: New pages are added and updated frequently. Check the following links often.

THINK about what you're reading - don't just "read" it.

Test whatever you read against Scripture.

Look up the definition of every word . so you understand what each one means.

Understand that the context is crucial to your understanding. If you take something out of context it changes the meaning in many cases. [Context means, what is being talked about, to whom, by whom, and under what circumstances.]

Do your own homework! Do not trust others to do it for you!

YAHWEH is not a man that He should lie. Numbers 23.19.

NOTE . These pages are a "work in progress". They're updated fairly often as new information or insights are provided that require a change in what's presented. Please check back regularly to see what may have changed since your last visit. Scripture verses used on the site are from Scripture For Seekers (see the Home Page) where the text has been completed . All of the books of Re-Thinking The New Covenant are completed. Work on The Old Covenant Revisited has been started. New books will be added as they're completed. They're not always presented on these pages in exactly the same format as they occur in the book due to space considerations but the text is the same. Every available book is in PDF format. Download or print your own copy today. Personal use is free . but these are not to be used for any commercial purpose. Please contact the site owner if you have an interest in commercial usage.

Aug 26, 2016, 12:01 PM

Decadron Side Effects In Detail, Dexadreson

Decadron Side Effects

For the Consumer

Applies to dexamethasone: oral elixir, oral solution, oral tablet

In addition to its needed effects, some unwanted effects may be caused by dexamethasone (the active ingredient contained in Decadron). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking dexamethasone:

More common:

Aggression

agitation

anxiety

blurred vision

decrease in the amount of urine

dizziness

fast, slow, pounding, or irregular heartbeat or pulse

headache

irritability

mental depression

mood changes

nervousness

noisy, rattling breathing

numbness or tingling in the arms or legs

pounding in the ears

shortness of breath

swelling of the fingers, hands, feet, or lower legs

trouble thinking, speaking, or walking

troubled breathing at rest

weight gain

Incidence not known:

Abdominal cramping and/or burning (severe)

abdominal pain

backache

bloody, black, or tarry stools

cough or hoarseness

darkening of skin

decrease in height

decreased vision

diarrhea

dry mouth

eye pain

eye tearing

facial hair growth in females

fainting

fatigue

fever or chills

flushed, dry skin

fractures

fruit-like breath odor

full or round face, neck, or trunk

heartburn and/or indigestion (severe and continuous)

increased hunger

increased thirst

increased urination

loss of appetite

loss of sexual desire or ability

lower back or side pain

menstrual irregularities

muscle pain or tenderness

muscle wasting or weakness

nausea

pain in back, ribs, arms, or legs

painful or difficult urination

skin rash

sleeplessness

sweating

trouble healing

trouble sleeping

unexplained weight loss

unusual tiredness or weakness

vision changes

vomiting

vomiting of material that looks like coffee grounds

Minor Side Effects

Some of the side effects that can occur with dexamethasone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

Increased appetite

Incidence not known:

Abnormal fat deposits on the face, neck, and trunk

acne

dry scalp

lightening of normal skin color

red face

reddish purple lines on the arms, face, legs, trunk, or groin

swelling of the stomach area

thinning of the scalp hair

For Healthcare Professionals

Applies to dexamethasone: compounding powder, inhalation aerosol with adapter, injectable solution, injectable suspension, intravenous solution, oral concentrate, oral liquid, oral tablet

Cardiovascular

Cardiovascular side effects have included bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, myocardial rupture following recent myocardial infarction, edema, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis and vasculitis. [Ref ]

Musculoskeletal

Musculoskeletal side effects have included muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humoral heads, pathologic fracture of long bones, and tendon rupture. [Ref ]

Gastrointestinal

Gastrointestinal side effects have included peptic ulcer with potential perforation and hemorrhage, perforation of small and large bowel, pancreatitis, abdominal distention, nausea, increased appetite, and ulcerative esophagitis. [Ref ]

Endocrine

Endocrine side effects have included development of cushingoid state, suppression of growth in children, and secondary adrenocortical and pituitary unresponsiveness. [Ref ]

Nervous system

Nervous system side effects have included convulsions, increased intracranial pressure with papilledema, vertigo, myalgia, arthralgia, malaise, headache, hiccups, and psychic disturbances. [Ref ]

Metabolic

Metabolic side effects have included negative nitrogen balance due to protein catabolism, decreased carbohydrate and glucose tolerance, weight gain, hirsutism, hypokalemic alkalosis, and increased requirements for insulin or oral hypoglycemic agents in diabetics. [Ref ]

Ocular

Ocular side effects have included posterior subcapsular cataracts, increased intraocular pressure, glaucoma, and exophthalmos. [Ref ]

Dermatologic

Dermatologic side effects have included impaired wound healing, thin fragile skin, petechiae and ecchymoses, dry scaly skin, erythema, acne, thinning scalp hair, urticaria, increased sweating, rash, striae, allergic dermatitis, urticaria, angioneurotic edema, and suppression of skin test reactions. [Ref ]

Psychiatric

Psychiatric side effects have included euphoria, insomnia, mood swings, personality changes, severe depression, and psychotic manifestations. [Ref ]

Hematologic

Hematologic side effects have included rare reports of thromboembolism. [Ref ]

Genitourinary

Genitourinary effects have included increase/decrease in motility and number of spermatozoa in men and menstrual irregularities in women. [Ref ]

Hepatic

Hepatic side effects have included reports of reversible hepatomegaly. Three case reports of children treated with high dose dexamethasone (the active ingredient contained in Decadron) describe the earliest diagnosis of hepatomegaly as early as 8 days from the start of therapy. [Ref ]

Hypersensitivity

Hypersensitivity side effects have included anaphylactoid reactions, anaphylaxis and angioedema. [Ref ]

Renal

Renal side effects have included fluid retention, sodium retention, and potassium loss, [Ref ]

References

1. Schmidt GB, Meier MA, Sadove MS "Sudden appearance of cardiac arrhythmias after dexamethasone." JAMA 221 (1972): 1402-4

2. New MI, Peterson RE, Saenger P, Levine LS "Evidence for an unidentified ACTH-induced steroid hormone causing hypertension." J Clin Endocrinol Metab 43 (1976): 1283-93

3. "Product Information. Decadron (dexamethasone)." Merck & Co, Inc, West Point, PA.

4. Rao G, Zikria EA, Miller WH, Samadani SR, Ford WB "Cardiac arrhythmias after dexamethasone." JAMA 222 (1972): 1185

5. Fadul CE, Lemann W, Thaler HT, Posner JB "Perforation of the gastrointestinal tract in patients receiving steroids for neurologic disease." Neurology 38 (1988): 348-52

6. McDonnell M, Evans N "Upper and lower gastrointestinal complications with dexamethasone despite H2 antagonists." J Paediatr Child Health 31 (1995): 152-4

7. Ludvik B, Clodi M, Kautzky-Willer A, Capek M, Hartter E, Pacini G, Prager R "Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans." Diabetologia 36 (1993): 84-7

8. Tsoi WW "Cushing's syndrome caused by analgesic/dexamethasone preparation." Ann Pharmacother 28 (1994): 1411

9. Spenney JG, Eure CA, Kreisberg RA "Hyperglycemic, hyperosmolar, nonketoacidotic diabetes. A complication of steroid and immunosupressive therapy." Diabetes 18 (1969): 107-10

10. Jaime Vazquez J "Persistent hiccup as a side-effect of dexamethasone treatment." Hum Exp Toxicol 12 (1993): 52

11. Kanwar AJ, Kaur S, Dhar S, Ghosh S "Hiccup--a side-effect of pulse therapy." Dermatology 187 (1993): 279

12. Francois J "Corticosteroid glaucoma." Ann Ophthalmol 9 (1977): 1075-80

13. Godel V, Regenbogen L, Stein R "On the mechanism of corticosteroid-induced ocular hypertension." Ann Ophthalmol 10 (1978): 191-6

14. Bluming AZ, Zeegen P "Cataracts induced by intermittent Decadron used as an antiemetic." J Clin Oncol 4 (1986): 221-3

15. Kobayashi Y, Akaishi K, Nishio T, Kobayashi Y, Kimura Y "Posterior subcapsular cataract in nephrotic children receiving steroid therapy." Am J Dis Child 128 (1974): 671-3

16. Whitmore SE "Dexamethasone injection-induced generalized dermatitis." Br J Dermatol 131 (1994): 296-7

17. Sechi GP, Piras MR, Demurtas A, Tanca S, Rosati G "Dexamethasone-induced schizoaffective-like state in multiple sclerosis: prophylaxis and treatment with carbamazepine." Clin Neuropharmacol 10 (1987): 453-7

18. Carroll BJ, Schroeder K, Mukhopadhyay S, Greden JF, Feinberg M, Ritchie J, Tarika J "Plasma dexamethasone concentrations and cortisol suppression response in patients with endogenous depression." J Clin Endocrinol Metab 51 (1980): 433-7

Not all side effects for Decadron may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .

Ponstan Forte Tablets 500mg, Opistan

PONSTAN FORTE TABLETS 500MG

Transcript

Ponstan Forte 500mg Tablets Mefenamic acid

Read all of this leaflet carefully before you start using this medicine. ?Keep this leaflet. You may need to read it again. ?If you have any further questions, ask your doctor or pharmacist. ?This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours. ?If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. In this leaflet: 1. What this medicine is and what it is used for 2. Before you take 3. How to take 4. Possible side effects 5. How to store 6. Further information

1. What this medicine is and what it is used for Ponstan Forte tablets contain mefenamic acid which is a non-steroidal anti-inflammatory drug (NSAID). They can help to relieve: ?symptoms of inflammation, such as redness and swelling ?pain and discomfort caused by arthritis, muscular or rheumatic disorders ?headache, muscle ache or toothache ?pain after operations, trauma ?childbirth pain ?painful or heavy periods.

2. Before you take Do NOT take Ponstan Forte if you: ?are allergic to mefenamic acid, to any other anti-inflammatory medicines (such as aspirin, ibuprofen, celecoxib), or to any of the other ingredients (see Section 6) ?have, or have ever had, stomach or intestinal conditions such as peptic ulcer, bleeding in the stomach or severe gastritis ?have an inflammatory bowel disease (e. g. ulcerative colitis, Crohn's disease) ?have severe heart, liver or kidney problems ?have just had heart bypass surgery ?are more than 6 months pregnant. If any of the above apply to you, speak to your doctor or pharmacist. Take special care with Ponstan Forte Before taking the tablets, tell your doctor if you: ?are taking any other NSAIDs (e. g. ibuprofen, diclofenac) ?are taking any other anti-inflammatory medicines including steroids (e. g. prednisolone) ?are taking aspirin or medicines that thin the blood (e. g. warfarin, clopidogrel) ?are taking antidepressants called selective serotonin re-uptake inhibitors (SSRIs) (e. g. paroxetine) ?have kidney or liver problems. Your doctor may check your kidney or liver function before and during treatment ?are elderly (see Section 3) ?are trying to become pregnant (see Section on Fertility) ?have stomach or digestive tract problems or if you ever had an upset stomach after taking pain killers such as aspirin. Bleeding in the stomach or gut can occur in patients taking Ponstan Forte ?have a bleeding disorder or if you are going to have a major operation. Ponstan Forte can affect the clotting of your blood. It can make you bleed more and for longer than usual ?have asthma, or a history of asthma, as this medicine may cause breathing difficulties ?have a connective tissue disorder, e. g. Systemic Lupus Erythematosus (SLE) ?have epilepsy ?are dehydrated (thirsty with dry skin, dark urine, dry mouth, headache) ?have heart problems, previous stroke or think that you might be at risk of these conditions (e. g. if you have high blood pressure, diabetes or high cholesterol or are a smoker). Additional monitoring may be carried out by your doctor. Medicines such as Ponstan Forte may be associated with a small increased risk of heart attack or stroke. Any risk is more likely with high doses and prolonged treatment. Do not exceed the recommended dose or duration of treatment. Taking other medicines Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription, and herbal preparations.

Some medicines may be affected by Ponstan Forte or they may affect how well Ponstan Forte will work. Tell your doctor or pharmacist if you are taking: ?medicines that can increase the chance of getting ulcers or a bleed in the stomach or gut, such as: - corticosteroids used to treat arthritis and inflammation - medicines such as anti-platelet agents, used to thin the blood (e. g. warfarin, aspirin, clopidogrel) - antidepressants called selective serotonin re-uptake inhibitors (SSRIs) (e. g. paroxetine) - any other anti-inflammatory medicines (e. g. diclofenac, celecoxib) ?aspirin including low doses of aspirin used to prevent your blood from clotting in certain heart conditions ?medicines used for high blood pressure (e. g. atenolol, ramipril, valsartan) ?diuretics (water tablets) or heart medicines (e. g. digoxin, sotalol, diltiazem) ?some diabetic medicines (e. g. glipizide, glibenclamide) ?medicines which suppress the immune system (e. g. ciclosporin, tacrolimus, methotrexate) ?lithium, a medicine used to treat mood swings and some types of depression ?a medicine usually prescribed through hospitals, called mifepristone (taken within the last 12 days) ?quinolone antibiotics (antibiotics used to treat infections) ?aminoglycoside antibiotics, used under medical supervision in hospitals ?zidovudine, a medicine used for HIV ?probenecid, a medicine used in special cases, to protect the kidneys ?medicines which bind to protein in the blood - (check with your pharmacist).

Blood tests Your doctor may test your blood during treatment. Pregnancy and breast-feeding Pregnancy Mefenamic acid will be passed to your unborn baby. It is not known how much it will affect your unborn baby in the first 6 months of pregnancy. DO NOT take the tablets in the last 3 months of pregnancy as they may delay the onset of labour and prolong its duration. They may also increase the likelihood of bleeding in the mother and in the baby. If you need to take these tablets, your doctor can help you decide whether or not to take them during the first 6 months of pregnancy. Breast-feeding Mefenamic acid passes into breast milk and can affect the baby. You should not take the tablets while breast-feeding unless advised by your doctor. Fertility DO NOT take the tablets if you are trying to become pregnant, as they may make it more difficult to get pregnant. You should inform your doctor if you are planning to become pregnant or if you have problems becoming pregnant. Ask your doctor for advice before taking any medicine. Driving and using machines Ponstan Forte may cause drowsiness, dizziness, fatigue or affect your vision. If any of these occur do not drive, use machinery, or perform any tasks that may require you to be alert. Important information about some of the ingredients of Ponstan Forte tablets ?lactose If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine. ?sunset yellow This may cause allergic reactions.

Always take Ponstan Forte tablets exactly as your doctor has told you and always read the label. Your doctor will decide on the appropriate dose to suit your condition. Ask your doctor or pharmacist if you are not sure. ?Take the tablets with or immediately after a meal. ?Do NOT drink alcohol while taking Ponstan Forte. Alcohol and smoking can irritate the stomach and make some of the side effects worse. Doses Adults and the elderly: the usual dose is 1 tablet three times a day. Elderly patients are at a higher risk of side effects and should take the lowest effective dose for the shortest possible time, with additional monitoring carried out by their doctor. Children: this medicine is NOT suitable for children under 12 years. If you take more than you should If you take more tablets than you should you may harm your stomach, kidneys and you may get seizures (fits). 1. Tell your doctor, pharmacist or nearest hospital casualty department immediately. 2. Take the container and any remaining tablets with you so that people can see what you have taken. 3. Do this even if you feel well. If you forget to take If you forget to take a dose take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue as usual. Do not use a double dose to make up for a missed dose. If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. Possible side effects Like all medicines, Ponstan Forte tablets can cause side effects, although not everybody gets them. Do not be alarmed by this list of possible side effects. You may not experience any of them.

STOP taking the tablets and seek medical help immediately if you have any of the following allergic reactions: ?difficulty breathing or swallowing, swelling of the face, lips, tongue or throat ?severe itching of the skin, with a red rash or raised lumps ?blistering of the mouth, eyes, and genital region, and patchy areas of rash, peeling skin or any of the following reactions ?diarrhoea ?passing blood in your stools (faeces/motions) ?passing black tarry stools ?vomiting any blood or dark particles that look like coffee grounds. Seek immediate medical attention if you have any of the following symptoms: ?indigestion or heartburn, abdominal pain (pain in your stomach) or other abnormal stomach symptoms, nausea (feeling sick), vomiting ?any unusual bruising or bleeding, for example nose-bleeds, pinpoint red spots on the skin, unusual purple bruise-like rash on the skin or in the mouth ?signs of anaemia such as feeling tired, breathless, and looking pale ?fever, sore throat, mouth ulcers, repeated infections or infections that will not go away. This may be due to a low level of white blood cells ?seizures (fits) ?signs of low sodium levels such as headache, nausea, vomiting, tiredness, muscle cramps ?sudden headache, stiff neck, fever, sensitivity to bright light, drowsiness and muscle pain, with or without a rash ?fever, rash, nausea, aches and pains, passing more or less urine than usual, passing red urine or passing urine at night. This may be due to changes in your kidneys ?sudden loss or blurring of vision, loss of colour vision, eye pain which worsens with eye movement ?headache, in particular on waking in the morning. This may be due to high blood pressure ?pain behind the ribs radiating towards the back, often worse when lying down, nausea, vomiting, fever. This may be due to inflammation of your pancreas ?yellowing of your skin or eyes, pale faeces and dark urine, unexplained persistent nausea, stomach problems, loss of appetite or unusual tiredness. This may be due to changes in your liver.

Continued over page 7/L/e/7

Tell your doctor if you get any of the following side effects: ?depression ?head-spins (vertigo) ?inability to sleep ?fatty stools ?hallucinations ?sweating ?nervousness ?rapid heartbeat (palpitations) ?ear pain ?mental confusion ?loss of appetite ?constipation or bloating ?blurred vision, eye irritation ?feeling ill (malaise) ?ringing or buzzing in the ears (tinnitus) ?numbness or tingling in hands or feet ?sudden poor blood sugar control if you have diabetes. Your doctor or pharmacist can measure your sugar levels ?asthma or asthma that is worse than usual ?swelling of your hands and feet (around the ankles) ?sore mouth (pain or ulcers on the tongue, cheeks, lips, throat or gums) ?dizziness, drowsiness, feeling lethargic and tired ?signs of low blood pressure such as light-headedness ?reactions to the sun. Your skin may become red, painful and swollen - do not sunbathe, use a sun bed, or expose your skin to artificial UV light. Medicines such as Ponstan Forte may be associated with a small increased risk of heart attack or stroke. (See Section 2 - end of 'Take special care'). Urine tests: Tell the doctor if you are having urine tests, as your medicine may affect the results. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard By reporting side effects you can help provide more information on the safety of this medicine.

5. How to store ?Keep out of the reach and sight of children. ?Do not take after the expiry date which is stated on the blister, carton/bottle/container. The expiry date refers to the last day of that month. ?Store below 30?C. ?Do not throw it away with your household waste or in water. Return all the unwanted medicine to your pharmacist. This will help to protect the environment.

6. Further information What Ponstan Forte Tablets contain ?The active ingredient is mefenamic acid (500 mg). ?The other ingredients are: lactose monohydrate, maize starch, pregelatinised maize starch, povidone, silicon dioxide, talc, magnesium stearate, croscarmellose sodium type A, sodium laurilsulfate, purified water. The film coating contains: hypromellose, titanium dioxide, lactose monohydrate, macrogol 4000, vanillin, quinoline yellow, sunset yellow (E110). The polish contains: purified water, beeswax white, carnauba wax yellow, polysorbate 20, sorbic acid. (See end of Section 2 for further information on lactose and sunset yellow). What Ponstan Forte Tablets look like and contents of the pack Ponstan Forte Tablets are yellow, film-coated tablets, marked 'Ponstan Forte' on one side. They are available in blister packs of 100 tablets, plastic containers of 100 or 500 tablets, and in plastic bottles of 6, 12, 84, 100 and 500 tablets. Not all types and pack sizes may be marketed. Marketing Authorisation Holder Chemidex Pharma Ltd, Chemidex House, Egham Business Village, Crabtree Road, Egham, Surrey TW20 8RB. Manufacturer Dales Pharmaceuticals Ltd, Snaygill Industrial Estate, Keighley Road, Skipton BD23 2RW. This leaflet was last revised in April 2015 'Ponstan' and 'Chemidex' are trade marks.

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Akamin Tablets, Akamin

Akamin

contains the active ingredient minocycline (hydrochloride)

Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about Akamin.

It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.

All medicines have benefits and risks. Your doctor has weighed the risks of you taking Akamin against the benefits expected for you.

If you have any concerns about taking this medicine, talk to your doctor or pharmacist.

Keep this leaflet with your medicine. You may need to read it again.

What Akamin is used for

Akamin is used to:

treat certain infections caused by bacteria

control acne.

Akamin is an antibiotic that belongs to a group of medicines called tetracyclines. These medicines work by stopping the growth of bacteria which cause infections or make acne worse.

Akamin will not work against infections caused by viruses, such as colds or flu.

Ask your doctor if you have any questions about why Akamin has been prescribed for you. Your doctor may have prescribed Akamin for another reason.

Akamin is available only with a doctor's prescription.

There is no evidence that Akamin is addictive.

Before you take Akamin

When you must not take it

Do not take Akamin if you are allergic to:

medicines containing minocycline (e. g. Minomycin)

medicines containing any other tetracycline antibiotic (e. g. Doryx, Doxylin, Vibramycin, Vibra-Tabs)

any of the ingredients listed at the end of this leaflet.

Some of the symptoms of an allergic reaction may include skin rash, itching or hives; swelling of the face, lips, tongue or other parts of the body; shortness of breath, wheezing or difficulty breathing.

Do not take Akamin if you are taking preparations containing:

vitamin A

retinoids, which are medicines used to treat - skin problems such as isotretinoin (Roaccutane, Oratane) and acitretin (Neotigason) - a certain type of leukaemia such as tretinoin (Vesanoid).

Taking Akamin with any of these preparations may lead to serious unwanted side effects.

Ask your doctor or pharmacist if you are not sure if you are taking one of these medicines.

Do not take Akamin if you are pregnant. Akamin is not recommended in the second and third terms of pregnancy as it may harm your developing baby. This may include enamel loss and staining of your baby's teeth.

Do not take Akamin if you are breastfeeding. Akamin passes into breast milk and may cause enamel loss and staining of your baby's teeth.

Do not take Akamin if you have any of the following medical conditions:

severe kidney disease

systemic lupus erythematosus (SLE).

Do not give Akamin to a child aged 8 years and under unless directed by the child's doctor. Tetracycline medicines, including Akamin, may cause permanent staining and enamel loss in developing teeth, and reduced bone growth.

Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.

If it has expired or is damaged, return it to your pharmacist for disposal.

If you are not sure whether you should start taking this medicine, talk to your doctor.

Before you start to take it

Tell your doctor if you have allergies to any other medicines, foods, dyes or preservatives.

Tell your doctor if you have or have had any of the following medical conditions:

Your doctor may want to take special care if you have any of these conditions.

Tell your doctor if you plan to have surgery, including dental surgery, especially if it requires a general anaesthetic.

If you have not told your doctor about any of the above, tell him/her before you start taking Akamin.

Taking other medicines

Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop. Some medicines and Akamin may interfere with each other. These include:

preparations containing vitamin A including vitamin supplements

retinoids used for skin problems, such as isotretinoin (Roaccutane, Oratane), acitretin (Neotigason) or for leukaemia such as tretinoin (Vesanoid)

medicines used to prevent blood clots, such as warfarin (Coumadin, Marevan)

penicillins, another group of antibiotics (e. g. Amoxil)

diuretics, also called fluid or water tablets (e. g. Lasix, Moduretic, Aldactone)

methoxyflurane (Penthrax), an inhalation general anaesthetic

the contraceptive pill (birth control pill).

Talk to your doctor about the additional need for a barrier method of contraception (e. g. condom or diaphragm) while taking Akamin. Akamin may decrease the effectiveness of some birth control pills.

Medicines which interfere with the absorption of Akamin include:

antacids (containing aluminium, calcium or magnesium) used for indigestion

preparations containing iron including vitamin supplements.

You can still take these medicines while you are taking Akamin. However, you must take Akamin at least 2 hours before or 2 hours after taking any of these medicines to make sure there is no problem with absorption.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine.

How to take Akamin

Follow all directions given to you by your doctor and pharmacist carefully. They may differ from the information contained in this leaflet.

If you do not understand the instructions on the bottle, ask your doctor or pharmacist.

How much to take

For treating infections, the usual dose for adults is 200 mg initially, followed by 100 mg every 12 hours.

For controlling acne, the usual dose is 50 mg twice a day.

However, depending on your condition and your response to this medicine, your doctor may ask you to take a different dose.

People with kidney problems may require smaller doses.

How to take it

Swallow the tablets or capsules whole with a full glass of water or milk while sitting or standing upright.

Stay upright for at least 30 minutes. Do not lie down immediately after taking Akamin. This is to help avoid irritation to your oesophagus (food pipe), which you may feel as heartburn or indigestion.

When to take it

Take Akamin during or immediately after a meal. This will reduce the chances of stomach upset.

Take Akamin at about the same time each day. Taking it at the same time each day will have the best effect. It will also help you remember when to take it.

How long to take it for

Keep taking Akamin until you finish the tablets or capsules, or for as long as your doctor recommends.

For infections, your doctor will tell you when to stop taking Akamin, as the length of treatment varies depending on the condition you have. This is usually 24 to 48 hours after the fever and signs of infection have gone.

Do not stop taking Akamin, even if you feel better after a few days, unless advised by your doctor. Your infection may not clear completely if you stop taking your medicine too soon.

For controlling acne, Akamin is normally taken for a few months.

If you forget to take it

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Otherwise, take the missed dose as soon as you remember, and then go back to taking your tablets or capsules as you would normally.

Do not take a double dose to make up for the dose you missed.

If you are not sure what to do, ask your doctor or pharmacist.

If you take too much (overdose)

Immediately telephone your doctor, or the Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency at the nearest hospital, if you think you or anyone else may have taken too much Akamin. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

If you take too much Akamin you may experience the following symptoms: nausea, vomiting, stomach pain, fall in blood pressure, tiredness.

While you are taking Akamin

Things you must do

If you develop a persistent headache with one or more of the following symptoms - nausea, vomiting, blurred vision or dizziness; see your doctor immediately. These may be signs of a rare condition associated with the use of minocycline called benign intracranial hypertension (increased pressure within the skull).

If you are taking Akamin for an infection and your symptoms do not improve within a few days, or if they become worse, tell your doctor.

If you become pregnant while you are taking Akamin, tell your doctor immediately.

If you get severe diarrhoea, tell your doctor or pharmacist immediately. Do this even if it occurs several weeks after you have stopped taking Akamin.

Diarrhoea may mean that you have a serious condition affecting your bowel. You may need urgent medical care. Do not take any medicines for the diarrhoea without checking with your doctor.

If you get a sore, white mouth or tongue while taking or soon after stopping Akamin, tell your doctor. Also tell your doctor if you get vaginal itching or discharge. This may mean you have a fungal infection called thrush. Sometimes the use of Akamin allows fungi to grow and the above symptoms to occur. Akamin does not work against fungi.

Before starting any new medicine, tell your doctor or pharmacist that you are taking Akamin.

Tell all the doctors, dentists and pharmacists who are treating you that you are taking Akamin.

If you are taking Akamin for a long time, visit your doctor regularly so that they can check on your progress. Your doctor may want you to have some blood tests from time to time.

Things you must not do

Do not stop taking Akamin or change the dose, without checking with your doctor. If you do not complete the full course prescribed by your doctor, all of the bacteria causing your infection may not be killed. Your infection may not clear completely or may return.

Do not let yourself run out of Akamin over the weekend or on holidays.

Do not use Akamin to treat any other conditions unless your doctor tells you to.

Do not give Akamin to anyone else, even if they have the same condition as you.

Things to be careful of

Protect your skin when you are in the sun, especially between 10 am and 3 pm. If outdoors, wear protective clothing and use a SPF 30+ sunscreen. Akamin may cause your skin to be much more sensitive to sunlight than it is normally. This may cause a skin rash, itching, redness or severe sunburn.

If your skin does appear to be burning, stop taking Akamin and tell your doctor.

Be careful driving or operating machinery until you know how Akamin affects you.

Akamin may cause dizziness or lightheadedness in some people. If you have any of these symptoms, do not drive, operate machinery or do anything else that could be dangerous.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Akamin. Akamin helps most people with their infections or acne, but it may have unwanted side effects in some people.

All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor if you notice any of the following and they worry you:

dizziness, lightheadedness, unsteadiness

headache

blurred vision, hearing loss

feeling sick (nausea), vomiting, diarrhoea

loss of appetite

sore mouth or tongue

difficulty in swallowing

oral thrush (white, furry sore tongue and mouth)

vaginal thrush (sore and itchy vagina, vaginal discharge)

swelling and itching in the anal and genital areas

heartburn, which may be due to irritation and ulceration of the oesophagus (food pipe).

The above list includes the milder side effects of Akamin.

Tell your doctor immediately or go to Accident and Emergency at the nearest hospital if you notice any of the following:

symptoms of a rare condition called benign intracranial hypertension (increased pressure within the skull) such as persistent headache along with one or more of the following - nausea, vomiting, blurred vision or dizziness

severe diarrhoea, usually with blood and mucus, stomach pain and fever

severe upper stomach pains, often with nausea and vomiting

signs of frequent infections such as fever, chills, sore throat or mouth ulcers

bruising or bleeding more easily than normal

being short of breath when exercising, often with tiredness, headaches, dizziness and looking pale and yellowing of the skin and/or eyes

swollen, stiff or painful joints

passing less urine than normal

signs of liver disease such as feeling generally unwell, loss of appetite, yellowing of the eyes or skin (jaundice), fever, itching and dark coloured urine

skin rash, itching, redness, flaking or blistering

symptoms of severe sunburn (such as redness, itching, swelling, blistering) that may occur more quickly than normal

convulsions or seizures

sudden signs of allergy such as rash, itching or hives on the skin, swelling of the face, lips, tongue or other parts of the body, shortness of breath, wheezing or trouble breathing.

The above list includes very serious side effects. You may need urgent medical attention or hospitalisation.

Contact your doctor if you notice any staining of your skin, teeth, tongue, lips, gums or nails.

Slight blue-black colour staining of the skin, teeth, nails, inside of the mouth, eyes, tears, breast milk or sweat has been reported. Staining may appear at any time during Akamin therapy but is more common during long-term treatment. Inform your doctor without delay if you notice any staining so that your treatment can be reviewed.

After finishing Akamin

Tell your doctor immediately if you notice any of the following, even if they occur several weeks after stopping treatment with Akamin:

watery and severe diarrhoea, which may also be bloody

severe stomach cramps.

These may be signs of a serious condition affecting your bowel.

After taking Akamin

Storage

Keep your tablets/capsules in the bottle until it is time to take them. If you take the tablets/capsules out of the bottle they may not keep well.

Keep your tablets or capsules in a cool dry place where the temperature stays below 25 °C.

Do not store Akamin or any other medicine in the bathroom or near a sink. Do not leave Akamin in the car or on window sills. Heat and dampness can destroy some medicines.

Keep Akamin where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Disposal

If your doctor tells you to stop taking Akamin, or your tablets or capsules have passed their expiry date, ask your pharmacist what to do with any that are left over.

Product description

What it looks like

Akamin is available in two strengths:

Akamin 50 mg - round, gold coloured, film-coated tablet, marked MC on one side and a Greek alpha symbol on the other side. Each bottle contains 60 tablets.

Akamin 100 mg - white and grey capsule, marked MC 100 on the white half and a Greek alpha symbol on the grey half. Each bottle contains 11 capsules.

Ingredients

The active ingredient in Akamin tablets and capsules is minocycline (as minocycline hydrochloride).

Akamin 50 tablets Each Akamin 50 mg tablet contains 50 mg of minocycline.

The tablets also contain:

lactose

sodium starch glycollate

povidone

microcrystalline cellulose

sodium lauryl sulfate

magnesium stearate

hypromellose

titanium dioxide CI77891 (E171)

macrogol 400

quinoline yellow CI47005 (E104)

sunset yellow FCF CI15985 (E110)

indigo carmine CI73015 (E132).

Akamin 100 capsules Each Akamin 100 capsule contains 100 mg of minocycline.

The capsules also contain:

lactose

maize starch

magnesium stearate

titanium dioxide CI77891(E171)

iron oxide black CI77499 (E172)

sodium lauryl sulfate

colloidal anhydrous silica

potable water

gelatin

shellac

propylene glycol

ammonium hydroxide

potassium hydroxide.

Akamin tablets and capsules are gluten free.

Manufacturer

Akamin is made in Australia by: Alphapharm Pty Limited (ABN 93 002 359 739) Chase Building 2 Wentworth Park Road Glebe NSW 2037 Phone: (02) 9298 3999

Medical Information Phone: 1800 028 365 www. alphapharm. com. au

Australian registration numbers:

50 mg tablets - AUST R 70852 100 mg capsules - AUST R 53641

This leaflet was prepared on 22 August 2008.

Published by MIMS November 2008

Consumers should be aware that the information provided by the Consumer Medicines Information (CMI) search (CMI Search) is for information purposes only and consumers should continue to obtain professional advice from a qualified healthcare professional regarding any condition for which they have searched for CMI. CMIs are provided by MIMS Australia. CMI is supplied by the relevant pharmaceutical company for each consumer medical product. All copyright and responsibility for CMI is that of the relevant pharmaceutical company. MIMS Australia uses its best endeavours to ensure that at the time of publishing, as indicated on the publishing date for each resource (e. g. Published by MIMS/myDr January 2007), the CMI provided was complete to the best of MIMS Australia's knowledge. The CMI and the CMI Search are not intended to be used by consumers to diagnose, treat, cure or prevent any disease or for any therapeutic purpose. Cirrus Media Pty Limited, its servants and agents shall not be responsible for the continued currency of the CMI, or for any errors, omissions or inaccuracies in the CMI and/or the CMI Search whether arising from negligence or otherwise or from any other consequence arising there from.

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Voltaren (Diclofenac Sodium) Drug Information Clinical Pharmacology - Prescribing Information At Rxl

CLINICAL PHARMACOLOGY

Mechanism Of Action

Diclofenac has analgesic. anti-inflammatory, and antipyretic properties.

The mechanism of action of VOLTAREN, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2 ).

Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro. Diclofenac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because diclofenac is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.

Pharmacokinetics

Absorption

Diclofenac is 100% absorbed after oral administration compared to IV administration as measured by urine recovery. However, due to first-pass metabolism. only about 50% of the absorbed dose is systemically available (see Table 1). Food has no significant effect on the extent of diclofenac absorption. However, there is usually a delay in the onset of absorption of 1 to 4.5 hours and a reduction in peak plasma levels of <20%.

Table 1. Pharmacokinetic Parameters for Diclofenac

Normal Healthy Adults (20-48 years)

Distribution

The apparent volume of distribution (V/F) of diclofenac sodium is 1.4 L/kg.

Diclofenac is more than 99% bound to human serum proteins, primarily to albumin. Serum protein binding is constant over the concentration range (0.15-105 mcg/mL) achieved with recommended doses.

Diclofenac diffuses into and out of the synovial fluid. Diffusion into the joint occurs when plasma levels are higher than those in the synovial fluid, after which the process reverses and synovial fluid levels are higher than plasma levels. It is not known whether diffusion into the joint plays a role in the effectiveness of diclofenac.

Elimination

Five diclofenac metabolites have been identified in human plasma and urine. The metabolites include 4'hydroxy-, 5-hydroxy-, 3'-hydroxy-, 4',5-dihydroxy - and 3'-hydroxy-4'-methoxy-diclofenac. The major diclofenac metabolite, 4'-hydroxy-diclofenac, has very weak pharmacologic activity. The formation of 4’-hydroxy - diclofenac is primarily mediated by CYP2C9. Both diclofenac and its oxidative metabolites undergo glucuronidation or sulfation followed by biliary excretion. Acylglucuronidation mediated by UGT2B7 and oxidation mediated by CYP2C8 may also play a role in diclofenac metabolism. CYP3A4 is responsible for the formation of minor metabolites, 5-hydroxy - and 3’-hydroxy-diclofenac. In patients with renal dysfunction, peak concentrations of metabolites 4'-hydroxy - and 5-hydroxy-diclofenac were approximately 50% and 4% of the parent compound after single oral dosing compared to 27% and 1% in normal healthy subjects.

Diclofenac is eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulfate conjugates of the metabolites. Little or no free unchanged diclofenac is excreted in the urine. Approximately 65% of the dose is excreted in the urine and approximately 35% in the bile as conjugates of unchanged diclofenac plus metabolites. Because renal elimination is not a significant pathway of elimination for unchanged diclofenac, dosing adjustment in patients with mild to moderate renal dysfunction is not necessary. The terminal half-life of unchanged diclofenac is approximately 2 hours.

Special Populations

Pediatric : The pharmacokinetics of VOLTAREN has not been investigated in pediatric patients.

Race : Pharmacokinetic differences due to race have not been identified.

Hepatic Impairment : Hepatic metabolism accounts for almost 100% of VOLTAREN elimination, so patients with hepatic disease may require reduced doses of VOLTAREN compared to patients with normal hepatic function.

Renal Impairment : Diclofenac pharmacokinetics has been investigated in subjects with renal insufficiency. No differences in the pharmacokinetics of diclofenac have been detected in studies of patients with renal impairment. In patients with renal impairment (inulin clearance 60-90, 30-60, and <30 mL/min; N=6 in each group), AUC values and elimination rate were comparable to those in healthy subjects.

Drug Interactions Studies

Voriconazole : When co-administered with voriconazole (inhibitor of CYP2C9, 2C19 and 3A4 enzyme), the Cmax and AUC of diclofenac increased by 114% and 78%, respectively (see DRUG INTERACTIONS ).

Aspirin : When NSAIDs were administered with aspirin, the protein binding of NSAIDs were reduced, although the clearance of free NSAID was not altered. The clinical significance of this interaction is not known. See Table 2 for clinically significant drug interactions of NSAIDs with aspirin (see DRUG INTERACTIONS ).

Last reviewed on RxList: 7/18/2016 This monograph has been modified to include the generic and brand name in many instances.

CLINICAL PHARMACOLOGY

Mechanism Of Action

Diclofenac has analgesic. anti-inflammatory, and antipyretic properties.

The mechanism of action of VOLTAREN, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2 ).

Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro. Diclofenac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because diclofenac is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.

Pharmacokinetics

Absorption

Diclofenac is 100% absorbed after oral administration compared to IV administration as measured by urine recovery. However, due to first-pass metabolism. only about 50% of the absorbed dose is systemically available (see Table 1). Food has no significant effect on the extent of diclofenac absorption. However, there is usually a delay in the onset of absorption of 1 to 4.5 hours and a reduction in peak plasma levels of <20%.

Table 1. Pharmacokinetic Parameters for Diclofenac

Normal Healthy Adults (20-48 years)

Distribution

The apparent volume of distribution (V/F) of diclofenac sodium is 1.4 L/kg.

Diclofenac is more than 99% bound to human serum proteins, primarily to albumin. Serum protein binding is constant over the concentration range (0.15-105 mcg/mL) achieved with recommended doses.

Diclofenac diffuses into and out of the synovial fluid. Diffusion into the joint occurs when plasma levels are higher than those in the synovial fluid, after which the process reverses and synovial fluid levels are higher than plasma levels. It is not known whether diffusion into the joint plays a role in the effectiveness of diclofenac.

Elimination

Five diclofenac metabolites have been identified in human plasma and urine. The metabolites include 4'hydroxy-, 5-hydroxy-, 3'-hydroxy-, 4',5-dihydroxy - and 3'-hydroxy-4'-methoxy-diclofenac. The major diclofenac metabolite, 4'-hydroxy-diclofenac, has very weak pharmacologic activity. The formation of 4’-hydroxy - diclofenac is primarily mediated by CYP2C9. Both diclofenac and its oxidative metabolites undergo glucuronidation or sulfation followed by biliary excretion. Acylglucuronidation mediated by UGT2B7 and oxidation mediated by CYP2C8 may also play a role in diclofenac metabolism. CYP3A4 is responsible for the formation of minor metabolites, 5-hydroxy - and 3’-hydroxy-diclofenac. In patients with renal dysfunction, peak concentrations of metabolites 4'-hydroxy - and 5-hydroxy-diclofenac were approximately 50% and 4% of the parent compound after single oral dosing compared to 27% and 1% in normal healthy subjects.

Diclofenac is eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulfate conjugates of the metabolites. Little or no free unchanged diclofenac is excreted in the urine. Approximately 65% of the dose is excreted in the urine and approximately 35% in the bile as conjugates of unchanged diclofenac plus metabolites. Because renal elimination is not a significant pathway of elimination for unchanged diclofenac, dosing adjustment in patients with mild to moderate renal dysfunction is not necessary. The terminal half-life of unchanged diclofenac is approximately 2 hours.

Special Populations

Pediatric : The pharmacokinetics of VOLTAREN has not been investigated in pediatric patients.

Race : Pharmacokinetic differences due to race have not been identified.

Hepatic Impairment : Hepatic metabolism accounts for almost 100% of VOLTAREN elimination, so patients with hepatic disease may require reduced doses of VOLTAREN compared to patients with normal hepatic function.

Renal Impairment : Diclofenac pharmacokinetics has been investigated in subjects with renal insufficiency. No differences in the pharmacokinetics of diclofenac have been detected in studies of patients with renal impairment. In patients with renal impairment (inulin clearance 60-90, 30-60, and <30 mL/min; N=6 in each group), AUC values and elimination rate were comparable to those in healthy subjects.

Drug Interactions Studies

Voriconazole : When co-administered with voriconazole (inhibitor of CYP2C9, 2C19 and 3A4 enzyme), the Cmax and AUC of diclofenac increased by 114% and 78%, respectively (see DRUG INTERACTIONS ).

Aspirin : When NSAIDs were administered with aspirin, the protein binding of NSAIDs were reduced, although the clearance of free NSAID was not altered. The clinical significance of this interaction is not known. See Table 2 for clinically significant drug interactions of NSAIDs with aspirin (see DRUG INTERACTIONS ).

Last reviewed on RxList: 7/18/2016 This monograph has been modified to include the generic and brand name in many instances.

Comprar Espimax (Aldactone) Sin Receta, Espimax

compra Espimax (Aldactone) en linea sin receta

Espimax (Aldactone) Explicacion

Espimax es realmente un tratamiento ideal, que le ayuda a la batalla junto con hiperaldosteronismo, hipocalemia, edema, ascitis, hirsutismo, calvicie (calvicie), los brotes de acne. Tambien se utiliza junto con otros medicamentos para tratar la miastenia gravis, brillante crecimiento, hipertension.

Espimax trabaja a traves de la manipulacion del grado de agua, asi como de sodio potable a traves de la reduccion de la reduccion de potasio real de todo el cuerpo.

Espimax tambien puede ser referido como espironolactona, Spirotone, Spiractin, Osyrol, Spiroctan, Spirolon, Verospiron.

Es realmente enemigos de radio de la aldosterona.

titulo general asociada con Espimax es en realidad espironolactona.

Marcas asociadas con Espimax Espimax tienden a ser, Spiractin, Spirotone, Spironol, Berlactone, Novo-Spiroton.

Espimax (Aldactone) Dosis

Espimax viene en:

25 mg Baja Dosis material de friccion

100mg material de friccion dosis regular

Usted es capaz de tener la asocia con Espimax justo despues de noches asociados con la terapia. Esto dependera dentro de la condicion de bienestar junto con otros aspectos de la persona.

Get Espimax pastillas por via oral junto con el agua potable, al mismo tiempo cada dia.

Por lo general, no moler o incluso masticar esto.

Get Espimax tan pronto como sea (por la manana real) o incluso dos veces al dia.

Si usted desea lograr mejores resultados por lo general no dejar de usar Espimax, de repente.

Espimax (Aldactone) Careciendo asocia con dosis

Por lo general, no reciben doble dosis. En caso de que salte la dosis que necesita para llevar una vez se tiene en cuenta en lo que respecta a su deficiente. Cuando es hora de la dosis que necesita para llevar a cabo su propia rutina de dosificacion normal.

Espimax (Aldactone)

En el caso de que la sobredosis de Espimax y que tambien se evita gran usted necesita comprobar hacia fuera su medico o incluso el medico de inmediato. Asociado con Espimax sobredosis: diarrea, vomitos, nauseas o vomitos, los poros de color rojo y alergias en la piel, falta de poder, mas lento el latido del corazon, alguna debilidad en la cadera y las piernas, sensacion de sueno, malos entendidos.

Espimax (Aldactone) Espacio de almacenamiento

La tienda debajo de veinticinco niveles D (77 niveles F). Fortalecer cualquier tipo de medicamento sin tocar a partir del dia de vencimiento. Mantener desde el lograr de los ninos.

Espimax (Aldactone) Efectos negativos

Espimax ofrece los efectos negativos. El mas tipico tienden a ser:

material de friccion diarrea

sensacion material de friccion con sueno

Material vientre molestias friccion

migrana material de friccion

problemas con el material de friccion ereccion del pene

mejorado el crecimiento de material de friccion del pelo

material de friccion mareo

poros y alergias en la piel de friccion materiales

material de friccion calambres

material de friccion area de la boca malestar dentro de las mujeres o los hombres bobos material de friccion

seca

material de friccion de combustible

nauseas o vomito moderado material de friccion

deseo friccion

material de friccion inestabilidad

tono de voz mas grave material de friccion

material de friccion fatiga

material de friccion menstruacion anormal

material de friccion afan

vomitando material de friccion

sangrado de la vagina justo despues material de friccion perimenopausia

Mucho menos tipicos y graves efectos negativos en todo el uso de Espimax:

respuestas reaccion alergica (urticaria, inhalando y exhalando, cuestiones de alergia, asi como erupcion) material de friccion

nauseas o vomitos material de friccion

debilucho o incluso arcilla de color material de heces friccion

problemas con la ingestion de material de friccion

material de friccion ictericia

alguna debilidad o incluso las molestias asociadas con material de friccion del tejido muscular

material de friccion malentendidos

material de friccion temblores

desmayos material de friccion

material de friccion hambre insuficiente

material de friccion caliente

problemas con pis material de friccion

material de friccion vision borrosa

frias, las amigdalas dolor, tos material de friccion

material de friccion escalofrios

ardiendo, hormigueo dentro del material de friccion pies o incluso los dedos

Los efectos negativos son indicaciones dependen de la medicacion que pueda estar utilizando, pero, ademas, confiar en su condicion de bienestar y otros aspectos.

Espimax (Aldactone) Contraindicaciones

Por lo general no reciben Espimax si usted es sensible a fin de elementos Espimax.

Por lo general no reciben Espimax si usted esta esperando otra manera tiene la intencion de tener un hijo, si no que realmente eres una mama medica. Danos Espimax su hijo.

Por lo general no reciben Espimax en caso de que usted esta usando diureticos ahorradores de potasio (por ejemplo, porque Aldactazide, amilorida (Moduretic, Midamor)), triamtereno (tales porque Maxzide, Dyazide, Dyrenium)).

Tenga cuidado con la utilizacion de inhibidores de Espimax (enalapril (Vasotec porque tal), fosinopril (tales porque Monopril), captopril (tales porque Capoten), benazepril (Lotensin porque tal), lisinopril (Zestril tales porque, Prinivil). quinapril (Accupril, porque tal), moexipril (tales porque Univasc), ramipril (tales porque Altace), trandolapril (tales porque Mavik)); farmacos esteroides dentales (dexametasona (Decadron tales porque, Dexone), prednisona (Deltasone porque tales), metilprednisolona (por ejemplo, porque Medrol)); aspirina junto con otros medicamentos anti-inflamatorios no esteroideos (naproxeno (por ejemplo porque alevoso, Naprosyn), el ibuprofeno (por ejemplo, porque Advil, Motrin), indometacina (Indocin tales porque)); diureticos; barbituricos, fenobarbital; digoxina (tales porque Digitek, Lanoxicaps, Lanoxin)); medicamentos para la hipertension, de litio (por ejemplo porque Lithobid, Eskalith); perindopril (tal porque Aceon). Puede ser danino para hacer uso de Espimax en caso de que se ven afectados por y tienen una breve historia asociada con enfermedades en el higado, enfermedad renal, potasio cantidades mas altas dentro de su torrente sanguineo, problemas con pis.

Tenga cuidado con esta medicacion particular, si usted quiere tener un tratamiento quirurgico.

Evitar las comidas con un buen grado de sodio.

Evitar medicamentos que pueden causar mareo.

?Tienes que ser cauteloso si usted esta viajando o incluso equipos de trabajo.

Por lo general, no dejar de usar Espimax, de repente.

Espimax (Aldactone) Preguntas comunes

Queen: Exactamente ?que implica Espimax?

El: Espimax es un medicamento eficaz que le ayuda a la batalla junto con hiperaldosteronismo, hipocalemia, edema, ascitis, hirsutismo, calvicie (calvicie), los brotes de acne. Se puede utilizar, ademas, junto con algunos otros medicamentos para tratar la miastenia gravis, brillante crecimiento, hipertension. Espimax trabaja a traves de la manipulacion del grado de agua potable, asi como la reduccion de sodio a traves de la reduccion de potasio real de toda cuerpo. Rara vez ocurre

Queen: ?Cuales son exactamente los efectos negativos Espimax?

El: Espimax ofrece los tipicos efectos negativos, por ejemplo, diarrea, sensacion de sueno, malestar vientre, migrana, problemas con la ereccion del pene, mejora el crecimiento del cabello, mareos, poros y alergias en la piel, calambres, molestias en las mujeres o piqueros hombres, secos area de la boca, el combustible, las nauseas o vomitos moderados, el deseo, la inestabilidad, el tono de voz mas grave, la fatiga, la menstruacion anormal, afan, vomitos, sangrado de la vagina justo despues de la perimenopausia. Sin embargo en la situacion que se asocia con ser rechazado asociado con componentes Espimax que son capaces de encontrar efectos negativos mas graves: nauseas o vomitos, debil o heces de color arcilla, incluso, problemas con la ingestion, la ictericia, alguna debilidad o incluso las molestias asociadas con el tejido muscular, alergias. Tingley, sangrado irregular o moretones, modificaciones latido del corazon, fatiga severa, malentendidos, temblores, sensacion de desmayo, hambre insuficiente, calidos, problemas con orinar, vision borrosa, frio, dolor de amigdalas, tos, escalofrios, asociado con la reaccion alergica (dificultad junto con inhalacion y la exhalacion, cerrando de las amigdalas, inflamacion, urticaria), quemando, hormigueo en el pie o incluso los dedos. La probabilidad de efectos negativos a aparecer depende de la posicion de bienestar, asi como, naturalmente, en la receta Espimax posterior correcta medications. A

Queen: ?Cuales son exactamente general, asi como las marcas asociadas con Espimax?

El: titulo general asociada con Espimax es en realidad espironolactona. Marcas asociadas con Espimax Espimax tienden a ser, Spiractin, Spirotone, Spironol, Berlactone, Novo-Spiroton. A

Reina: ?Se puede realmente consumir alcohol?

El: Por supuesto que no, lo que realmente es inaceptable aprecian alcoholica beverages. A

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Hydrochlorothiazide is used for treating high blood pressure. It is also used to treat fluid buildup in the body caused by certain conditions (eg, heart failure, liver cirrhosis, kidney problems) or medicines (eg, corticosteroids, estrogen). It may be used alone or with other medicines. Hydrochlorothiazide is a thiazide diuretic. It helps the kidneys to remove fluid from the body.

Use Hydrochlorothiazide as directed by your doctor.

Take Hydrochlorothiazide by mouth with or without food.

Hydrochlorothiazide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.

If you miss a dose of Hydrochlorothiazide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Hydrochlorothiazide.

Store Hydrochlorothiazide at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hydrochlorothiazide out of the reach of children and away from pets.

Do NOT use Hydrochlorothiazide if:

you are allergic to any ingredient in Hydrochlorothiazide

you are unable to urinate

you are taking dofetilide or ketanserin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Hydrochlorothiazide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have had a severe allergic reaction (eg, rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) to a sulfonamide medicine (eg, sulfamethoxazole)

if you have gout, liver problems, (eg, cirrhosis), lupus, kidney problems, diabetes, asthma, parathyroid gland problems, or high blood cholesterol or lipid levels

if you have high or low blood electrolyte levels (eg, sodium, potassium, magnesium, calcium)

if you are taking another medicine for high blood pressure.

Some medicines may interact with Hydrochlorothiazide. Tell your health care provider if you are taking any other medicines, especially any of the following:

Digoxin, dofetilide, or ketanserin because the risk of irregular heartbeat may be increased

Barbiturates (eg, phenobarbital), corticotropin, corticosteroids (eg, prednisone), or narcotic pain medicines (eg, codeine) because they may increase the risk of Hydrochlorothiazide's side effects

Cholestyramine, colestipol, or nonsteroidal anti-inflammatory medicines (NSAIDs) (eg, ibuprofen) because they may decrease Hydrochlorothiazide's effectiveness

Diazoxide or lithium because the risk of their side effects may be increased by Hydrochlorothiazide

Diabetes medicines (eg, glipizide, metformin) or insulin because their effectiveness may be decreased by Hydrochlorothiazide.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hydrochlorothiazide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Hydrochlorothiazide may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Hydrochlorothiazide with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Hydrochlorothiazide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Your doctor may also prescribe a potassium supplement for you. If so, take the potassium supplement exactly as prescribed. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.

Tell your doctor or dentist that you take Hydrochlorothiazide before you receive any medical or dental care, emergency care, or surgery.

Tell your doctor if you will be exposed to high temperatures. The risk of certain side effects (eg, low blood sodium levels) may be increased in hot weather.

Hydrochlorothiazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Hydrochlorothiazide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

Hydrochlorothiazide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.

Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Hydrochlorothiazide may interfere with certain lab tests, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking Hydrochlorothiazide.

Lab tests, including kidney function, blood pressure, and electrolyte levels, may be performed while you use Hydrochlorothiazide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Hydrochlorothiazide with caution in the elderly; they may be more sensitive to its effects, especially dizziness.

Pregnancy and breast-feeding: Hydrochlorothiazide may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hydrochlorothiazide while you are pregnant. Hydrochlorothiazide is found in breast milk. If you are or will be breast-feeding while you use Hydrochlorothiazide, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; lightheadedness (especially when sitting up or standing); loss of appetite; nausea; temporary blurred vision.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dark urine; decreased urination; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; increased thirst; joint pain, swelling, warmth, or redness (especially of the big toe joint); mental or mood changes; muscle pain or cramps; numbness or tingling; red, swollen, blistered, or peeling skin; seizures; severe or persistent dizziness; severe or persistent nausea or stomach pain; shortness of breath; unusual bruising or bleeding; unusual drowsiness, restlessness, tiredness, or weakness; unusually dry mouth; vomiting; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Avastin Intravenous Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Avastin

Avastin intravenous

GENERIC NAME(S): BEVACIZUMAB

Warnings

This medication can rarely cause a tear in the stomach /intestines (gastrointestinal perforation). It may also increase the risk of serious (possibly fatal) bleeding, such as bleeding from the stomach /intestines or in the brain. You should not receive this medication if you have any serious bleeding problems. Get medical help right away if you have any signs of these serious side effects, including bloody or black/tarry stools, persistent or severe stomach/abdominal pain. constipation with vomiting. vomit that is bloody or looks like coffee grounds, coughing up blood. shortness of breath, dizziness /fainting. unusual or persistent tiredness/weakness. severe headache. fever.

This medication may also cause wounds to heal slowly or poorly or cause the wounds to break open. It can also rarely cause very serious (possibly fatal) skin and tissue infections that spread quickly. Get medical help right away if you have wounds that are not healing well, a fever, severe pain/redness/heat/swelling at the surgery site or other areas on the skin, fluid-filled blisters in the skin, discolored/scaling/peeling skin, confusion, dizziness, or fainting. You should not receive this medication for at least 4 weeks before and after a major surgery and until the wound from the surgery is fully healed.

Uses

This medication is a man-made antibody (IgG1) used to treat kidney. cervical, ovarian, colon. and rectal cancer. Bevacizumab is also used to treat lung cancer (non-small cell type), certain types of brain tumors. and cancer found in the fallopian tube or lining of the abdominal wall (peritoneal). This drug works by blocking a certain protein (vascular endothelial growth factor-VEGF) thereby decreasing the blood supply to the tumor and slowing tumor growth.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat certain serious eye conditions (such as age-related macular degeneration. macular edema ).

How to use Avastin intravenous

This medication is given by infusion into a vein by a health care professional. The first dose is usually given over 90 minutes. If you tolerate the first dose well, then later infusions may be given over a shorter time (60 or 30 minutes).

The dosage is based on your medical condition, response to previous therapy, and your weight. Tell your doctor if your weight changes.

Use this medication regularly in order to get the most benefit from it. Try not to miss any doses.

Side Effects

See also Warning section.

Dry mouth. cough. voice changes, loss of appetite, diarrhea. vomiting. constipation. mouth sores, nausea, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist right away.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: swelling of ankles /feet, sudden weight gain. fast heartbeat, signs of infection (e. g. fever, persistent sore throat ), muscle cramps. muscle loss, yellowing eyes /skin, dark urine, difficulty urinating, signs of kidney problems (such as change in the amount of urine, frothy urine).

Symptoms of a severe infusion reaction that may occur during bevacizumab treatment include difficulty breathing, flushing, severe dizziness, nausea/vomiting, shaking, or chest pain. Tell your healthcare professional if you have any of these symptoms during your treatment. Your doctor will monitor you closely and will temporarily stop your treatment if a reaction occurs.

Bevacizumab may rarely cause blood clots (such as pulmonary embolism. stroke, heart attack. deep vein thrombosis ). You may be at increased risk for blood clots if you have a history of blood clots, heart/blood vessel disease, or if you are immobile (such as on very long plane flights or being bedridden). If you use estrogen-containing products, these may also increase your risk. Before using this medication, if you have any of these conditions report them to your doctor or pharmacist. Get medical help right away if any of these side effects occur: shortness of breath/rapid breathing, chest/jaw/left arm pain, unusual sweating, confusion, sudden dizziness/fainting, pain/swelling/warmth in groin/calf, sudden/severe headaches, slurred speech, weakness on one side of the body, sudden vision changes.

This medication can cause bleeding. Some episodes may be minor including nosebleeds, minor gum bleeding, and vaginal bleeding. If these persist or worsen, notify your doctor or pharmacist promptly. Other episodes may be more serious including stomach bleeding or bleeding in the lungs (see also Warning section).

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Your doctor may control your blood pressure with medication.

Rarely, bevacizumab may cause a condition called PRES (posterior reversible encephalopathy syndrome). Get medical help right away if you develop persistent headache, seizures, sudden vision changes, mental/mood changes (e. g. confusion).

This medication may affect the ovaries, possibly reducing fertility and causing hormone changes. Talk to your doctor for more details.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

See also Warning and Side Effects sections.

Before using bevacizumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal ulcers, bleeding problems (such as recent bloody vomiting or coughing up blood), recent major surgery, recent injuries/wounds, high blood pressure, kidney disease, diabetes.

Before having surgery or any medical procedure, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Bevacizumab can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Caution is advised when using this drug in the elderly because they may be at greater risk for side effects (e. g. blood clots, kidney effects such as protein in the urine). See also Side Effects section.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor. Women of child-bearing age should use reliable forms of birth control while using this medication and for 6 months after stopping treatment. If you become pregnant or think you may be pregnant, tell your doctor right away.

Based on information from related drugs, this medication may pass into breast milk. Therefore, breast-feeding while using this medication is not recommended. Also, do not breast-feed for extended period after stopping this drug. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

A product that may interact with this drug is: sunitinib.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe headache.

Notes

Laboratory and/or medical tests (e. g. blood pressure monitoring, urine tests for protein, kidney function tests, bilirubin levels, complete blood counts-CBC) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule.

Storage

Not applicable. This medication is given in a clinic and will not be stored at home.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised April 2016. Copyright(c) 2016 First Databank, Inc.

Images

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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ADHD Drug Side Effects

Drug Overdose

Intalsolone, Intalsolone

Prednisolone is used for treating allergies, arthritis, breathing problems (e. g. asthma), certain blood disorders, collagen diseases (e. g. lupus), certain eye diseases (e. g. keratitis), cancer (e. g. leukemia), endocrine problems (e. g. adrenocortical insufficiency), intestinal problems (e. g. ulcerative colitis), swelling due to certain conditions, or skin conditions (e. g. psoriasis).

Availability: In Stock (34 packs)

Prednisolone is used for treating allergies, arthritis, breathing problems (e. g. asthma), certain blood disorders, collagen diseases (e. g. lupus), certain eye diseases (e. g. keratitis), cancer (e. g. leukemia), endocrine problems (e. g. adrenocortical insufficiency), intestinal problems (e. g. ulcerative colitis), swelling due to certain conditions, or skin conditions (e. g. psoriasis). It may also be used for other conditions as determined by your doctor.

Use Prednisolone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Prednisolone by mouth with or without food. Swallow Prednisolone whole. Do not break, crush, or chew before swallowing. Continue taking Prednisolone even if you feel good. Do not miss any doses.

Drug Class and Mechanism

Prednisolone is a corticosteroid. It works by modifying the body's immune response to various conditions and decreasing inflammation.

If you miss a dose of Prednisolone, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Store Prednisolone at 77 degrees F (25 degrees C). Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prednisolone out of the reach of children and away from pets.

Do not use Prednisolone if:

you are allergic to any ingredient of Prednisolone; you have a systemic fungal infection, a certain type of malaria, inflammation of the optic nerve, or herpes infection of the eye; you are scheduled to have a live or attenuated live vaccination (eg, smallpox); you are taking mifepristone. Contact your doctor or health care provider right away if any of these apply to you.

Important: Prednisolone may lower the ability of your body to fight infection. Avoid contacts with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills. If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does. If you are taking Prednisolone regularly over a long period of time, carry an ID card at all times that says you take Prednisolone. Do not receive a live vaccine (eg, measles, mumps) while you are taking Prednisolone. Talk with your doctor before you receive any vaccine. Tell your doctor or dentist that you take Prednisolone before you receive any medical or dental care, emergency care, or surgery. Diabetes patients - Prednisolone may affect your blood sugar. Check blood sugar levels. Ask your doctor before you change the dose of your diabetes medicine. Lab tests, including adrenal function tests, may be performed while you use Prednisolone. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Caution is advised when using Prednisolone in children; they may be more sensitive to its effects. Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they take Prednisolone. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prednisolone while you are pregnant. Prednisolone is found in breast milk. If you are or will be breast-feeding while you use Prednisolone, check with your doctor. Discuss any possible risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

acne; clumsiness; dizziness; facial flushing; feeling of a whirling motion; general body discomfort; headache; increased appetite; increased sweating; nausea; nervousness; sleeplessness; upset stomach. Seek medical attention right away if any of these severe side effects occur: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual period; changes in skin color; chest pain; easy bruising or bleeding; infection (e. g. fever, chills, sore throat); mental or mood changes (e. g. depression); muscle pain, weakness, or wasting; seizures; severe nausea or vomiting; sudden severe dizziness or headache; swelling of feet or legs; tendon or bone pain; thinning of skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

Prednisolone is to be used only by the patient for whom it is prescribed. Do not share it with other people.

Uricelax? Uric Acid Support - Alleviate High Uric Acid Level Symptoms Naturally, Uricnol

Healthy Uric Acid Levels

Uricelax™ is comprised of powerful ingredients (Tumeric, Cherry Extract, & Rutin) that have been shown in studies to help balance and maintain healthy levels of uric acid.* Uricelax™ can help with the following:

1. Helps Balance and Maintain Healthy Uric Acid Levels* 2. Promotes Normal Uric Acid Metabolism* 3. Helps Optimize Healthy Kidney Function* 4. Helps Manage Joint Discomfort and Provides Optimal Joint Support for Flexibility (Mobility/Movement) 5. Helps Support a Healthy Immune System*

Uricelax™ is the #1 choice for maintaining and balancing optimal uric acid levels. It also supports joint health and enhances your overall well-bing and quality of life.*

What is Uric Acid Metabolism?

Uric acid is produced after the breakdown of purine, an ingredient that is found in many foods. After the production of uric acid, it navigates through the blood and travels to the kidneys and passes through. Once you urinate, most of the uric acid production is released from the body.

When specific foods are ingested or the natural break down of cells occurs, the body may produce excessive amounts of uric acid. It may be challenging for the kidneys to reduce uric acid from the blood when this happens. This promotes higher levels of uric acid in the blood.

The gut is responsible for a portion of the elimination of uric acid, while the kidneys are responsible for one third of the elimination. Deficiencies in the kidneys may be hereditarily determined and are common in many people who have unbalanced levels of uric acid.

Who May Be At Risk of Unbalanced Levels of Uric Acid

Uric acid mostly affects men who are between the ages of 40 and 50. There is some evidence through studies that show this may be genetically predisposed with many individuals having a family history. After menopause women may find that they may need to support a healthy balance of uric acid as well.

Monthly Autoship Program

By joining our convenient AutoShip Program, you won’t have to worry about your supply of Uricelax™ running out, or the inconvenience of re-ordering the product. You may select the option of receiving one bottle every thirty (30) days, or three (3) bottles every 90 days. It’s easy, hassle-free, and you may cancel at anytime!

How Long is Uricelax™ taken for?

Uricelax™ is a dietary supplement that delivers nutrients you may be missing in your diet. Individuals should take Uricelax daily, as directed. The Buy 2, Get 1 FREE Special is recommended for daily dosage and helps provide a special discount on the purchase of the product.

1. http://www. mayoclinic. com/health/high-uric-acid-level/MY00160 2. http://www. webmd. com/a-to-z-guides/uric-acid-in-blood

Alejandro Queral, Alendro-Q

United Way of the Columbia-Willamette

Alejandro Queral

Bio

What I do at United Way: I lead the talented Systems Planning and Performance team in developing and implementing organizational systems that will allow United Way to make data-informed investments, learn about what what we can do better and share the resulting knowledge to spur effective action in the community.

My favorite thing about United Way: My favorite thing about United Way is the passion and commitment of staff to the critical mission of breaking the cycle of childhood poverty, and the desire to innovate and take risks in the pursuit of best outcomes.

I volunteer at: Oregon Environmental Council

A book (or book series): "Che: A Revolutionary Life" by Jon Lee Anderson

A hobby: Guitar playing

A karaoke song: "Tangled Up In Blue" by Bob Dylan

A time of day: Late night

A favorite food: Tacos de lo que sea

Words to live by: "Life is what happens while you're busy making other plans."

United Way of the Columbia-Willamette

Alejandro Queral

Bio

What I do at United Way: I lead the talented Systems Planning and Performance team in developing and implementing organizational systems that will allow United Way to make data-informed investments, learn about what what we can do better and share the resulting knowledge to spur effective action in the community.

My favorite thing about United Way: My favorite thing about United Way is the passion and commitment of staff to the critical mission of breaking the cycle of childhood poverty, and the desire to innovate and take risks in the pursuit of best outcomes.

I volunteer at: Oregon Environmental Council

A book (or book series): "Che: A Revolutionary Life" by Jon Lee Anderson

A hobby: Guitar playing

A karaoke song: "Tangled Up In Blue" by Bob Dylan

A time of day: Late night

A favorite food: Tacos de lo que sea

Words to live by: "Life is what happens while you're busy making other plans."

Hofcomant, Hofcomant

Amantadine

Chemical Name

Foreign Names

Generic Names

Amantadina (OS: DCIT)

Amantadine (OS: BAN, DCF)

1-Adamantanamine (IS: WHO)

1-Adamantylazan (IS)

GP 38026 (IS)

Ly 38982 (IS)

Amantadine Hydrochloride (OS: USAN, BANM, JAN)

1-Adamantanamine hydrochloride (IS)

EXP 105-1 (IS)

Ly 37407 (IS)

Amantadine (chlorhydrate d') (PH: Ph. Eur. 8)

Amantadine Hydrochloride (PH: BP 2016, JP XVI, USP 38)

Amantadine hydrochloride (PH: Ph. Eur. 8)

Amantadinhydrochlorid (PH: Ph. Eur. 8)

Amantadini hydrochloridum (PH: Ph. Eur. 8)

1-Adamantanamine sulfate (IS)

Amantadinhemisulfat (IS)

Brand Names

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

Why register with MediGuard?

We are a free monitoring service designed for patients like you who want to be in the driver seat of your medical treatment. We have a community of more than 2.6 million members and offer the services below.

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Actison (Amantadine)

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DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

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Gatilox Plus; Eye Drop, Sun Pharmaceutical Industries Ltd, Gatilox

GATILOX PLUS - Eye Drop, Sun Pharmaceutical Industries Ltd.

Composit uses/ indication of GATILOX PLUS :

Maintenance in schizophrenia and other psychoses, Moderate to severe pain, Ocular inflammation, Resistant schizophrenia, and can also be given in adjunctive therapy as an alternative drug of choice in Allergic conjunctivitis, Migraine, Short term managment of moderate to severe acute post-operative pain.

Antibiotic, bacterial infections such as conjunctivitis, sinusitis, skin and skin structure infections, cystitis. It kills the bacteria that cause infection.

Bladder irrigation, Ear, eye, nose and throat irrigation, Gingivitis, Perodontal diseases, Preoperative disinfection of unbroken skin, Stomatitis, Thrush, Tonsillitis, Urethral irrigation, Burns, Wounds.

Composit contra indication of GATILOX PLUS :

Fornax

Fornax Chemica

First named the Chemical Furnace . this constellation was formed by Nicolas Louis de Lacaille, 1752, in honor of the accomplishments of his good friend and famous chemist Antoine Laurent Lavoisier who leaves us the Metric System, modern chemistry, and Fornax - his combustion furnace. Lacaille created Fornax out of several faint stars in the constellation Eridanus.

In ancient Rome, Fornax was the goddess of bread and baking, her festival was the Fornacalia . It was held in the Forum by the Curia, or ancient unions of kinsmen, under the superintendence of the Curio Maximus . or president of the masters of the curia. Corn was baked in ovens in the ancient fashion. All who missed the festival were called fools ( stulti ), as being supposed not to know which was their curia . and had to make an offering at the so-called Feast of Fools ( stultorum feria ) on the 17th February, the day of the Quirinalia [1 ].

The word Fornax comes from the Indo-European * gwher - 'To heat, warm'. Derivatives include: burn? . brimstone (Middle English brinnen . 'to burn', and ston . 'stone', hence the word literally means 'burnstone'), brindled (tawny or grayish with streaks or spots of a darker color, brindled cats are tabby cats, from Old Norse brenna . to burn), brand (from Old French brand, sword), firebrand (a burning stick carried as a torch or a weapon, also somebody with a strong or aggressive personality who encourages unrest), brandy . brandish . therm . - therm . thermo -, thermos . - thermy . hypothermia . thermometer . (these words from Greek thermos ), forceps (from *formi-caps . from formus . 'hot', and capere . 'to catch'), fornicate (brothels were called fornices . i. e. 'arches', because prostitutes used to gather 'under the arches' of certain buildings of ancient Rome), Fornax . furnace . hornito (an oven-shaped mound in volcanic regions, sometimes emitting smoke or vapor, from Spanish horno . 'oven', from Latin furnus ), fornix (a structure or fold in the shape of an arch, especially either of two bands of white fibers that meet at the base of the brain), ghee (Sanskrit ghrtam . ghee, clarified butter). [Pokorny gwher - 493, bh(e)reu - 143. Watkins ] California from ' calida fornax ', 'hot furnace'.

'Therma' (hot) is from the town in Greece called Therma . known for its hot springs. Therma ( Therme ) was a town in ancient Mygdonia (which was later incorporated into Macedon), situated at the northeastern extremity of a great gulf of the Aegean Sea, the Thermaic Gulf. Therma was later renamed Thessalonica (alternative name Salonica) by Cassander [2 ].

Pokorny links the two Indo-European roots; * gwher - (Pokarny 493) and * bhreue - (Pokarny 143). Chambers ( Dictionary of Etymology ) says the word burn (from * gwher -) is related to brew (from * bhreue - ) through an Indo-European present stem * bhre-n-u - to the root * bhreu - of Old English breowan . to brew . Klein ( Comprehensive Etymological Dictionary ) also gives an explanation of how the words burn . brew . and bread . are related to each other. This gives a link between the two words Fornax and bread . Fornax was the goddess of bread and the furnace . Indo-European root * bhreue - Also bhreu -, bhreeu -. 'To boil, bubble, effervesce, burn, with derivatives referring to cooking and brewing': brew (from Old English breowan . to brew), bread (from Old English bread ), blaff . broth (from Old English broth ), broil? (a rowdy argument, a brawl), embroil . imbroglio (a difficult or intricate situation, from Vulgar Latin * brodum . broth), brood (keep eggs warm, from Old English brod ), breed (to beget or cherish offspring, breed, 'a warming,' hatching), braise (simmer), braze? (to solder two pieces of metal together), brazier? (a metal pan for holding burning coals or charcoal), breeze? (the refuse left when coke or charcoal is made, from Old French brese . burning coal, ember), yeast . barm (the yeasty foam that rises to the surface of fermenting malt liquors), barmy (full of barm, foamy, or eccentric, daft), ferment . fervent . fervid (marked by great passion or zeal), fervor (from Latin febris, fever), defervescence (the abatement of a fever), effervesce (from Latin fervere . to be boiling or fermenting), bourn? (also bourne . a small stream, a brook), burn? (a small stream, a brook, from Old English burn . burna . spring, stream), phreatic (relating to ground water, from Greek phrear . spring, the Greek word phreatos meaning well or underground water, this term refers to types of plants with extensive root systems that utilize water from the underlying water table). [Pokorny bh(e)reu - 143, 2. bher - 132. Watkins ] Perhaps Brazil from Portuguese brassa . or a derivative of Old French breze ( whence French braise) . 'glowing charcoal' [Klein ].

John Ayto explains that the word breath comes ultimately from the Indo-European base * bhreue - 'burn, heat' (source also of braise . breed . brood . and probably brawn ), and in its original Indo-European form * bhretos appears to have meant something like the 'steam, vapor, etc given off by something burning or cooking.'. [John Ayto, Dictionary of Word Origins ]

The word broth (from * bhreue - ) resembles the word brothel . Brothels were called fornices (hence fornication ), i. e. 'arches', because prostitutes used to gather 'under the arches' of certain buildings of ancient Rome [3 ]. The word brothel comes from another * bhreu - root: * bhreu - Also bhreue -. 'To cut, break up'. Derivatives: brittle . brothel (from Old English breothan . to deteriorate, from Germanic * breuthan . to be broken up), bruise . frustule (the hard, siliceous bivalve shell of a diatom), frustum (the portion of a solid – normally a cone or pyramid – which lies between two parallel planes cutting the solid). [Pokorny 1. bhreu - 169, 2. bhreu - s - 171. Watkins ]

The word brand from Old French brand . and Old Norse brandr . also meant a 'sword, or sword-blade.'

"In alchemical terms, 'the Philosopher's Sword' is the fire in the furnace" [ Penguin Symbols ].

An athanor, or alchemists' furnace, is an Arabic word ' al-tannur ', Hebrew tannur . related to Akkadian tinnuru . meaning an furnace or oven, usually shaped like an egg [4 ]. Built of brick or clay, it was designed to keep an even heat over long periods of time. The alchemists considered it an incubator and sometimes referred to it as the 'House of the Chick.' [5 ] The making of the Philosopher's Stone (also referred to as the Philosopher's Egg) requires the combination of the purest possible sulfur and the purest possible mercury, to be combined in the athanor [6 ].

Alchemists regarded the athanor, in which the process of transmutation took place, [as] an egg-shaped matrix, like the world itself, which is a gigantic egg, the Orphic egg which may be found at the base of all initiatory rites both in Egypt and in Greece. And just as Ruah Elohim, the Spirit of the Lord, floats upon the waters, so ought the spirit of the world, the spirit of life, to float above the waters of the athanor. The alchemist needed the skill to make this spirit his own.(GRIM p. 392) [ Penguin Symbols ]

English translations of the Bible commonly refer to sulfur as brimstone ( brim - from * gwher -, means 'burnstone', from the same root as the word fornax ). The 'smell of sulfur' usually refers to the odor of hydrogen sulfide, e. g. from rotten eggs. [Alchemically, the eagle (Aquila ) was a symbol of purified sulfur and Greek aetos . eagle, is cognate with the words avis and egg ]. The words brood . meaning keeping eggs warm, and breed meaning to give birth or hatch (from * bhreue - ), suggests something to do with eggs. There is a likeness between the word 'oven' (which the Latins called fornax), and the Latin word for egg; 'ovum'? The furnace is often likened to the womb in alchemy and symbolism; but I suggest the ovary is more appropriate (one in birds, two in mammals; there is a two-headed eagle symbol?). [The shell of the egg (and seashells) might be adjacent Sculptor ; the words sculpt - and shell are related.]

The Latin word fornix means an arch, a vaulted ceiling, and a brothel . In ancient Rome prostitutes were restricted to soliciting only under the archways, or fornixes of the outer city gates. The fornix in the brain is an arch-like shape like a vaulted ceiling. A fornix is also found at the superior end of the vagina, described as a 'vaulted ceiling' surrounding the cervix of the uterus. Both fornixes in the body have only architectural purposes [7 ].

“ Fornicator ( fornicarius ). Prostitute ( fornicatrix ), a woman whose body is public and common. Such bodies would lie prostrate under arches, places that they call fornices - hence also the term 'female fornicator ' ( fornicaria ). (Vergil Aen . 6.631: And with the archway ( fornix ) opposite)” [ The Etymologies of Isidore of Seville . 7th century AD, 219.]

Latin far is cognate with the word 'barley' (not 'spelt'):

“An oven ( furnus ) is a term derived from 'spelt' ( far ), because bread made from spelt is baked there” [ The Etymologies of Isidore of Seville . 7th century AD, 311.]

The name California ( calida fornax . Latin for hot furnace ) is most commonly believed to have derived from a fictional character, Queen Califia . in a 1510 book The Exploits of Esplandian . about a fictional paradise peopled by black Amazons and ruled by Queen Califia [8 ]. There might be a resemblance in mythology to the capital of the Amazons, Themiscyra, on the river Thermodon (maybe related to therm ?), where Hercules encountered the Amazons, his ninth labor was to retrieve the girdle of Hippolyte, queen of the Amazons. The Amazon river runs mostly through Brazil (the word Brazil is possibly from * bhreue - ).

© Anne Wright 2008.

Fornax Chemica . or Fornax Chymiae . the Chemical Furnace was formed by La Caille from stars within the southern bend of the River (Eridanus ); but modem astronomers, by whom it is still recognized, have abbreviated the title to Fornax .

The Chinese know it as Tien Yu . Heaven's Temporary Granary.

Bode changed the early name in 1782 to Apparatus chemicus . and translated it as the Chemische Apparat . Chymische Ofen . and l’A pparat Chimique . an alteration in honor of the celebrated chemist Antoine Laurent Lavoisier. These titles, however, have fallen into disuse. Gould assigns to it no stars, from 3.6 to 7th magnitudes. alpha, the lucida . is a double of 4th and 7th magnitudes, 3" apart, with a position angle of 320°, and may be binary. It comes to the meridian on the 19th of December.

[ Star Names : Their Lore and Meaning . Richard H. Allen, 1889.]

Viagra - Erectile Dysfunction, Betnoval G

Common use The main component of Viagra is Sildenafil Citrate. Sildenafil Citrate affects the response to sexual stimulation. It acts by enhancing smooth muscle relaxation using nitric oxide, a chemical that is normally released in response to sexual stimulation. This smooth muscle relaxation allows increased blood flow into certain areas of the penis, which leads to an erection. Sildenafil Citrate is applied for the treatment of erectile dysfunction (impotence) in men and pulmonary arterial hypertension. Sildenafil Citrate may also be used for other purposes not listed above.

Dosage and direction Usually the recommended dose is 50 mg. It is taken approximately 0,5-1 hour before sexual activity. Do not take Viagra more then once a day. A high fat meal may delay the time of the effect of this drug. Try not to eat grapefruit or drink grapefruit juice while you are being treated with Sildenafil Citrate .

Precautions Before you start taking Sildenafil Citrate. tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Aged people may be more sensitive to the side effects of the drug.

Viagra is contraindicated in patients who take another medicine to treat impotence or using a nitrate drug for chest pain or heart problems. This medicine should not be taken by women and children as well as in patients with a known hypersensitivity to any component of the tablet.

Possible side effect The most common side effects are headache, flushing, heartburn, stomach upset, nasal stuffiness, lightheadedness, dizziness or diarrhea. A serious allergic reaction to this drug is very rare, but seek immediate medical help if it occurs. Many people who use this medicine do not have serious side effects. In case you notice any side effects not listed above, contact your doctor or pharmacist.

Drug interaction This drug should not be used with nitrates and recreational drugs called "poppers" containing amyl or butyl nitrite; alpha-blocker medications; other medications for impotence; high blood pressure medicines, etc. Consult your doctor or pharmacist for more details.

Missed dose Viagra is used as needed, so you are unlikely to be on a dosing schedule.

Overdose If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store the drugs in the bathroom. Keep all drugs away from reach of children and pets.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clomiphene - Fda Prescribing Information, Side Effects And Uses, Clomifene

Clomiphene

* Includes 28 ectopic pregnancies, 4 hydatiform moles, and 1 fetus papyraceous. † Indicates percentage of surviving infants from these pregnancies.

The overall survival of infants from multiple pregnancies including spontaneous abortions, stillbirths, and neonatal deaths is 73%.

Fetal/Neonatal Anomalies and Mortality. The following fetal abnormalities have been reported subsequent to pregnancies following ovulation induction therapy with Clomiphene citrate tablets USP during clinical trials. Each of the following fetal abnormalities were reported at a rate of <1% (experiences are listed in order of decreasing frequency): Congenital heart lesions, Down syndrome, club foot, congenital gut lesions, hypospadias, microcephaly, harelip and cleft palate, congenital hip, hemangioma, undescended testicles, polydactyly, conjoined twins and teratomatous malformation, patent ductus arteriosus, amaurosis, arteriovenous fistula, inguinal hernia, umbilical hernia, syndactyly, pectus excavatum, myopathy, dermoid cyst of scalp, omphalocele, spina bifida occulta, ichthyosis, and persistent lingual frenulum. Neonatal death and fetal death/stillbirth in infants with birth defects have also been reported at a rate of <1%. The overall incidence of reported congenital anomalies from pregnancies associated with maternal Clomiphene citrate tablets USP ingestion during clinical studies was within the range of that reported for the general population.

In addition, reports of congenital anomalies have been received during postmarketing surveillance of Clomiphene citrate (see ADVERSE REACTIONS ).

Indications and Usage for Clomiphene

Clomiphene citrate tablets USP is indicated for the treatment of ovulatory dysfunction in women desiring pregnancy. Impediments to achieving pregnancy must be excluded or adequately treated before beginning Clomiphene citrate tablets USP therapy. Those patients most likely to achieve success with Clomiphene therapy include patients with polycystic ovary syndrome (see WARNINGS: Ovarian Hyperstimulation Syndrome ), amenorrhea-galactorrhea syndrome, psychogenic amenorrhea, post-oral-contraceptive amenorrhea, and certain cases of secondary amenorrhea of undetermined etiology.

Properly timed coitus in relationship to ovulation is important. A basal body temperature graph or other appropriate tests may help the patient and her physician determine if ovulation occurred. Once ovulation has been established, each course of Clomiphene citrate tablets USP should be started on or about the 5th day of the cycle. Long-term cyclic therapy is not recommended beyond a total of about six cycles (including three ovulatory cycles). (See DOSAGE AND ADMINISTRATION and PRECAUTIONS .)

Clomiphene citrate tablets USP is indicated only in patients with demonstrated ovulatory dysfunction who meet the conditions described below:

Patients who are not pregnant.

Patients without ovarian cysts. Clomiphene citrate tablets USP should not be used in patients with ovarian enlargement except those with polycystic ovary syndrome. Pelvic examination is necessary prior to the first and each subsequent course of Clomiphene citrate tablets USP treatment.

Patients without abnormal vaginal bleeding. If abnormal vaginal bleeding is present, the patient should be carefully evaluated to ensure that neoplastic lesions are not present.

Patients with normal liver function.

In addition, patients selected for Clomiphene citrate tablets USP therapy should be evaluated in regard to the following:

Estrogen Levels. Patients should have adequate levels of endogenous estrogen (as estimated from vaginal smears, endometrial biopsy, assay of urinary estrogen, or from bleeding in response to progesterone). Reduced estrogen levels, while less favorable, do not preclude successful therapy.

Primary Pituitary or Ovarian Failure. Clomiphene citrate tablets USP therapy cannot be expected to substitute for specific treatment of other causes of ovulatory failure.

Endometriosis and Endometrial Carcinoma. The incidence of endometriosis and endometrial carcinoma increases with age as does the incidence of ovulatory disorders. Endometrial biopsy should always be performed prior to Clomiphene citrate tablets USP therapy in this population.

Other Impediments to Pregnancy. Impediments to pregnancy can include thyroid disorders, adrenal disorders, hyperprolactinemia, and male factor infertility.

Uterine Fibroids. Caution should be exercised when using Clomiphene citrate tablets USP in patients with uterine fibroids due to the potential for further enlargement of the fibroids.

There are no adequate or well-controlled studies that demonstrate the effectiveness of Clomiphene citrate tablets USP in the treatment of male infertility. In addition, testicular tumors and gynecomastia have been reported in males using Clomiphene. The cause and effect relationship between reports of testicular tumors and the administration of Clomiphene citrate tablets USP is not known.

Although the medical literature suggests various methods, there is no universally accepted standard regimen for combined therapy (ie, Clomiphene citrate tablets USP in conjunction with other ovulation-inducing drugs). Similarly, there is no standard Clomiphene citrate tablets USP regimen for ovulation induction in in vitro fertilization programs to produce ova for fertilization and reintroduction. Therefore, Clomiphene citrate tablets USP is not recommended for these uses.

Contraindications

Hypersensitivity

Clomiphene citrate tablets USP is contraindicated in patients with a known hypersensitivity or allergy to Clomiphene citrate or to any of its ingredients.

Pregnancy

Pregnancy Category X. Clomiphene citrate tablets USP use in pregnant women is contraindicated, as Clomiphene citrate does not offer benefit in this population.

Available human data do not suggest an increased risk for congenital anomalies above the background population risk when used as indicated. However, animal reproductive toxicology studies showed increased embryo-fetal loss and structural malformations in offspring. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential risks to the fetus. (See PRECAUTIONS: Pregnancy .)

Liver Disease. Clomiphene citrate tablets USP therapy is contraindicated in patients with liver disease or a history of liver dysfunction (see also INDICATIONS AND USAGE and ADVERSE REACTIONS ).

Abnormal Uterine Bleeding. Clomiphene citrate tablets USP is contraindicated in patients with abnormal uterine bleeding of undetermined origin (see INDICATIONS AND USAGE ).

Ovarian Cysts. Clomiphene citrate tablets USP is contraindicated in patients with ovarian cysts or enlargement not due to polycystic ovarian syndrome (see INDICATIONS AND USAGE and WARNINGS ).

Other. Clomiphene citrate tablets USP is contraindicated in patients with uncontrolled thyroid or adrenal dysfunction or in the presence of an organic intracranial lesion such as pituitary tumor (see INDICATIONS AND USAGE ).

Warnings

Visual Symptoms

Patients should be advised that blurring or other visual symptoms such as spots or flashes (scintillating scotomata) may occasionally occur during therapy with Clomiphene citrate tablets USP. These visual symptoms increase in incidence with increasing total dose or therapy duration. These visual disturbances are usually reversible; however, cases of prolonged visual disturbance have been reported with some occurring after Clomiphene citrate tablets USP discontinuation. The visual disturbances may be irreversible, especially with increased dosage or duration of therapy. Patients should be warned that these visual symptoms may render such activities as driving a car or operating machinery more hazardous than usual, particularly under conditions of variable lighting.

These visual symptoms appear to be due to intensification and prolongation of afterimages. Symptoms often first appear or are accentuated with exposure to a brightly lit environment. While measured visual acuity usually has not been affected, a study patient taking 200 mg Clomiphene citrate tablets USP daily developed visual blurring on the 7th day of treatment, which progressed to severe diminution of visual acuity by the 10th day. No other abnormality was found, and the visual acuity returned to normal on the 3rd day after treatment was stopped.

Ophthalmologically definable scotomata and retinal cell function (electroretinographic) changes have also been reported. A patient treated during clinical studies developed phosphenes and scotomata during prolonged Clomiphene citrate tablets USP administration, which disappeared by the 32nd day after stopping therapy.

Postmarketing surveillance of adverse events has also revealed other visual signs and symptoms during Clomiphene citrate tablets USP therapy (see ADVERSE REACTIONS ).

While the etiology of these visual symptoms is not yet understood, patients with any visual symptoms should discontinue treatment and have a complete ophthalmological evaluation carried out promptly.

Ovarian Hyperstimulation Syndrome

The ovarian hyperstimulation syndrome (OHSS) has been reported to occur in patients receiving Clomiphene citrate therapy for ovulation induction. OHSS may progress rapidly (within 24 hours to several days) and become a serious medical disorder. In some cases, OHSS occurred following cyclic use of Clomiphene citrate therapy or when Clomiphene citrate was used in combination with gonadotropins. Transient liver function test abnormalities suggestive of hepatic dysfunction, which may be accompanied by morphologic changes on liver biopsy, have been reported in association with OHSS.

OHSS is a medical event distinct from uncomplicated ovarian enlargement. The clinical signs of this syndrome in severe cases can include gross ovarian enlargement, gastrointestinal symptoms, ascites, dyspnea, oliguria, and pleural effusion. In addition, the following symptoms have been reported in association with this syndrome: pericardial effusion, anasarca, hydrothorax, acute abdomen, hypotension, renal failure, pulmonary edema, intraperitoneal and ovarian hemorrhage, deep venous thrombosis, torsion of the ovary, and acute respiratory distress. The early warning signs of OHSS are abdominal pain and distention, nausea, vomiting, diarrhea, and weight gain. Elevated urinary steroid levels, varying degrees of electrolyte imbalance, hypovolemia, hemoconcentration, and hypoproteinemia may occur. Death due to hypovolemic shock, hemoconcentration, or thromboembolism has occurred. Due to fragility of enlarged ovaries in severe cases, abdominal and pelvic examination should be performed very cautiously. If conception results, rapid progression to the severe form of the syndrome may occur.

To minimize the hazard associated with occasional abnormal ovarian enlargement associated with Clomiphene citrate tablets USP therapy, the lowest dose consistent with expected clinical results should be used. Maximal enlargement of the ovary, whether physiologic or abnormal, may not occur until several days after discontinuation of the recommended dose of Clomiphene citrate tablets USP. Some patients with polycystic ovary syndrome who are unusually sensitive to gonadotropin may have an exaggerated response to usual doses of Clomiphene citrate tablets USP. Therefore, patients with polycystic ovary syndrome should be started on the lowest recommended dose and shortest treatment duration for the first course of therapy (see DOSAGE AND ADMINISTRATION ).

If enlargement of the ovary occurs, additional Clomiphene citrate tablets USP therapy should not be given until the ovaries have returned to pretreatment size, and the dosage or duration of the next course should be reduced. Ovarian enlargement and cyst formation associated with Clomiphene citrate tablets USP therapy usually regress spontaneously within a few days or weeks after discontinuing treatment. The potential benefit of subsequent Clomiphene citrate tablets USP therapy in these cases should exceed the risk. Unless surgical indication for laparotomy exists, such cystic enlargement should always be managed conservatively.

A causal relationship between ovarian hyperstimulation and ovarian cancer has not been determined. However, because a correlation between ovarian cancer and nulliparity, infertility, and age has been suggested, if ovarian cysts do not regress spontaneously, a thorough evaluation should be performed to rule out the presence of ovarian neoplasia.

Precautions

General

Careful attention should be given to the selection of candidates for Clomiphene citrate tablets USP therapy. Pelvic examination is necessary prior to Clomiphene citrate tablets USP treatment and before each subsequent course (see CONTRAINDICATIONS and WARNINGS ).

Information for Patients

The purpose and risks of Clomiphene citrate tablets USP therapy should be presented to the patient before starting treatment. It should be emphasized that the goal of Clomiphene citrate tablets USP therapy is ovulation for subsequent pregnancy. The physician should counsel the patient with special regard to the following potential risks:

Visual Symptoms: Advise that blurring or other visual symptoms occasionally may occur during or shortly after Clomiphene citrate tablets USP therapy. It should be made clear to the patient that, in some instances, visual disturbances may be prolonged, and possibly irreversible, especially with increased dosage or duration of therapy. Warn that visual symptoms may render such activities as driving a car or operating machinery more hazardous than usual, particularly under conditions of variable lighting (see WARNINGS ).

The patient should be instructed to inform the physician whenever any unusual visual symptoms occur. If the patient has any visual symptoms, treatment should be discontinued and complete ophthalmologic evaluation performed.

Abdominal/Pelvic Pain or Distention: Ovarian enlargement may occur during or shortly after therapy with Clomiphene citrate tablets USP. To minimize the risks associated with ovarian enlargement, the patient should be instructed to inform the physician of any abdominal or pelvic pain, weight gain, discomfort, or distention after taking Clomiphene citrate tablets USP (see WARNINGS ).

Metabolism Disorders: Cases of hypertriglyceridemia have been reported. Preexisting or family history of hyperlipidemia and use of higher than recommended dose and/or longer duration of treatment with Clomiphene citrate are associated with a risk of hypertriglyceridemia. Periodic monitoring of plasma triglycerides is recommended in patients with preexisting or family history of hyperlipidemia (see ADVERSE REACTIONS ). Please refer to the DOSAGE AND ADMINISTRATION section for recommended dosage and treatment duration.

Multiple Pregnancy: Inform the patient that there is an increased chance of multiple pregnancy, including bilateral tubal pregnancy and coexisting tubal and intrauterine pregnancy, when conception occurs in relation to Clomiphene citrate tablets USP therapy. The potential complications and hazards of multiple pregnancy should be explained.

Spontaneous Abortion and Congenital Anomalies: Inform the patient that the available data suggest no increase in the rates of spontaneous abortion (miscarriage) or congenital anomalies with maternal Clomiphene citrate tablets USP use compared to rates in the general population.

During clinical investigation, the experience from patients with known pregnancy outcome (Table 1) shows a spontaneous abortion rate of 20.4% and stillbirth rate of 1.0%. (See CLINICAL STUDIES ). Among the birth anomalies spontaneously reported as individual cases since commercial availability of Clomiphene citrate tablets USP, the proportion of neural tube defects has been high among pregnancies associated with ovulation induced by Clomiphene citrate tablets USP, but this has not been supported by data from population-based studies.

Drug Interactions

Drug interactions with Clomiphene citrate tablets USP have not been documented.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term toxicity studies in animals have not been performed to evaluate the carcinogenic or mutagenic potential of Clomiphene citrate.

Oral administration of Clomiphene citrate tablets USP to male rats at doses of 0.3 or 1 mg/kg/day caused decreased fertility, while higher doses caused temporary infertility. Oral doses of 0.1 mg/kg/day in female rats temporarily interrupted the normal cyclic vaginal smear pattern and prevented conception. Doses of 0.3 mg/kg/day slightly reduced the number of ovulated ova and corpora lutea, while 3 mg/kg/day inhibited ovulation.

Pregnancy

Fetal Risk Summary

Pregnancy Category X. (See CONTRAINDICATIONS .) Clomiphene citrate use in pregnant women is contraindicated, as Clomiphene citrate tablets USP treatment does not offer benefit in this population.

Available human data do not suggest an increased risk for congenital anomalies above the background population risk. However, animal reproductive toxicology studies showed increased embryo-fetal loss and structural malformations in offspring. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential risks to the fetus.

To avoid inadvertent Clomiphene citrate tablets USP administration during early pregnancy, appropriate tests should be utilized during each treatment cycle to determine whether ovulation and/or pregnancy occurs. Patients should be evaluated carefully to exclude ovarian enlargement or ovarian cyst formation between each treatment cycle. The next course of Clomiphene citrate tablets USP therapy should be delayed until these conditions have been excluded.

The available human data from epidemiologic studies do not show any apparent cause and effect relationship between Clomiphene citrate periconceptual exposure and an increased risk of overall birth defects, or any specific anomaly. However, due to the small number of cases of congenital anomalies occurring in Clomiphene citrate treated women, these epidemiologic studies were only able to rule out large differences in risk. The studies did not consider factors associated with female subfertility and were unable to adjust for other important confounders.

In addition, available data do not support an increased rate of spontaneous abortion among subfertile women treated with Clomiphene citrate for ovulation induction.

Oral administration of Clomiphene citrate to pregnant rats during organogenesis at doses of 1 to 2 mg/kg/day resulted in hydramnion and weak, edematous fetuses with wavy ribs and other temporary bone changes. Doses of 8 mg/kg/day or more also caused increased resorptions and dead fetuses, dystocia, and delayed parturition, and 40 mg/kg/day resulted in increased maternal mortality. Single doses of 50 mg/kg caused fetal cataracts, while 200 mg/kg caused cleft palate. Following injection of Clomiphene citrate 2 mg/kg to mice and rats during pregnancy, the offspring exhibited metaplastic changes of the reproductive tract. Newborn mice and rats injected during the first few days of life also developed metaplastic changes in uterine and vaginal mucosa, as well as premature vaginal opening and anovulatory ovaries. These findings are similar to the abnormal reproductive behavior and sterility described with other estrogens and antiestrogens.

In rabbits, some temporary bone alterations were seen in fetuses from dams given oral doses of 20 or 40 mg/kg/day during pregnancy, but not following 8 mg/kg/day. No permanent malformations were observed in those studies. Also, rhesus monkeys given oral doses of 1.5 to 4.5 mg/kg/day for various periods during pregnancy did not have any abnormal offspring.

Nursing Mothers

It is not known whether Clomiphene citrate tablets USP is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised if Clomiphene citrate tablets USP is administered to a nursing woman. In some patients, Clomiphene citrate tablets USP may reduce lactation.

Ovarian Cancer

Prolonged use of Clomiphene citrate tablets USP may increase the risk of a borderline or invasive ovarian tumor (see ADVERSE REACTIONS ).

Adverse Reactions

Clinical Trial Adverse Events. Clomiphene citrate tablets USP, at recommended dosages, is generally well tolerated. Adverse reactions usually have been mild and transient and most have disappeared promptly after treatment has been discontinued. Adverse experiences reported in patients treated with Clomiphene citrate during clinical studies are shown in Table 2.

Table 2. Incidence of Adverse Events in Clinical Studies (Events Greater than 1%) (n = 8029*)

* Includes 498 patients whose reports may have been duplicated in the event totals and could not be distinguished as such. Also, excludes 47 patients who did not report symptom data.

The following adverse events have been reported in fewer than 1% of patients in clinical trails: Acute abdomen, appetite increase, constipation, dermatitis or rash, depression, diarrhea, dizziness, fatigue, hair loss/dry hair, increased urinary frequency/volume, insomnia, light-headedness, nervous tension, vaginal dryness, vertigo, weight gain/loss.

Patients on prolonged Clomiphene citrate tablets USP therapy may show elevated serum levels of desmosterol. This is most likely due to a direct interference with cholesterol synthesis. However, the serum sterols in patients receiving the recommended dose of Clomiphene citrate tablets USP are not significantly altered. Ovarian cancer has been infrequently reported in patients who have received fertility drugs. Infertility is a primary risk factor for ovarian cancer; however, epidemiology data suggest that prolonged use of Clomiphene may increase the risk of a borderline or invasive ovarian tumor.

Postmarketing Adverse Events

The following adverse reactions have been identified during post approval use of Clomiphene citrate. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Body as a Whole: Fever, tinnitus, weakness

Cardiovascular: Arrhythmia, chest pain, edema, hypertension, palpitation, phlebitis, pulmonary embolism, shortness of breath, tachycardia, thrombophlebitis

Central Nervous System: Migraine headache, paresthesia, seizure, stroke, syncope

Dermatologic: Acne, allergic reaction, erythema, erythema multiforme, erythema nodosum, hypertrichosis, pruritus, urticaria

• Abnormal bone development: skeletal malformations of the skull, face, nasal passages, jaw, hand, limb (ectromelia including amelia, hemimelia, and phocomelia), foot (clubfoot), spine, and joints

• Cardiac abnormalities: septal heart defects, muscular ventricular septal defect, patent ductus arteriosus, tetralogy of Fallot, and coarctation of the aorta

• Chromosomal disorders: Downs syndrome

• Ear abnormalities and deafness

• Gastrointestinal tract abnormalities: cleft lip and palate, imperforate anus, tracheoesophageal fistula, diaphragmatic hernia, omphalocele

• Genitalia abnormalities: hypospadias, cloacal exstrophy

• Lung tissue malformations

• Malformations of the eye and lens (cataract)

• Neoplasms: neuroectodermal tumor, thyroid tumor, hepatoblastoma, lymphocytic leukemia

• Nervous system abnormalities: neural tube defects (anencephaly, meningomyelocele), microcephaly, and hydrocephalus

• Renal abnormalities: renal agenesis and renal dysgenesis

• Others: dwarfism, mental retardation

Genitourinary: Endometriosis, ovarian cyst (ovarian enlargement or cysts could, as such, be complicated by adnexal torsion), ovarian hemorrhage, tubal pregnancy, uterine hemorrhage, reduced endometrial thickness

Hepatic: Transaminases increased, hepatitis

Metabolism Disorders: Hypertriglyceridemia, in some cases with pancreatitis

Musculoskeletal: Arthralgia, back pain, myalgia

Neoplasms: Liver (hepatic hemangiosarcoma, liver cell adenoma, hepatocellular carcinoma); breast (fibrocystic disease, breast carcinoma); endometrium (endometrial carcinoma); nervous system (astrocytoma, pituitary tumor, prolactinoma, neurofibromatosis, glioblastoma multiforme, brain abcess); ovary (luteoma of pregnancy, dermoid cyst of the ovary, ovarian carcinoma); trophoblastic (hydatiform mole, choriocarcinoma); miscellaneous (melanoma, myeloma, perianal cysts, renal cell carcinoma, Hodgkin's lymphoma, tongue carcinoma, bladder carcinoma)

Psychiatric: Anxiety, irritability, mood changes, psychosis -

Visual Disorders: Abnormal accommodation, cataract, eye pain, macular edema, optic neuritis, photopsia, posterior vitreous detachment, retinal hemorrhage, retinal thrombosis, retinal vascular spasm, temporary or prolonged loss of vision, possibly irreversible

Other: Leukocytosis, thyroid disorder

Drug Abuse and Dependence

Tolerance, abuse, or dependence with Clomiphene citrate tablets USP has not been reported.

Overdosage

Signs and Symptoms

Toxic effects accompanying acute overdosage of Clomiphene citrate tablets USP have not been reported. Signs and symptoms of overdosage as a result of the use of more than the recommended dose during Clomiphene citrate tablets USP therapy include nausea, vomiting, vasomotor flushes, visual blurring, spots or flashes, scotomata, ovarian enlargement with pelvic or abdominal pain. (See CONTRAINDICATIONS: Ovarian Cyst .)

Oral LD 50. The acute oral LD 50 of Clomiphene citrate tablets USP is 1700 mg/kg in mice and 5750 mg/kg in rats. The toxic dose in humans is not known.

Dialysis. It is not known if Clomiphene citrate tablets USP is dialyzable.

Treatment

In the event of overdose, appropriate supportive measures should be employed in addition to gastrointestinal decontamination.

Clomiphene Dosage and Administration

General Considerations

The workup and treatment of candidates for Clomiphene citrate tablets USP therapy should be supervised by physicians experienced in management of gynecologic or endocrine disorders. Patients should be chosen for therapy with Clomiphene citrate tablets USP only after careful diagnostic evaluation (see INDICATIONS AND USAGE ). The plan of therapy should be outlined in advance. Impediments to achieving the goal of therapy must be excluded or adequately treated before beginning Clomiphene citrate tablets USP. The therapeutic objective should be balanced with potential risks and discussed with the patient and others involved in the achievement of a pregnancy.

Ovulation most often occurs from 5 to 10 days after a course of Clomiphene citrate tablets USP. Coitus should be timed to coincide with the expected time of ovulation. Appropriate tests to determine ovulation may be useful during this time.

Recommended Dosage

Treatment of the selected patient should begin with a low dose, 50 mg daily (1 tablet) for 5 days. The dose should be increased only in those patients who do not ovulate in response to cyclic 50 mg Clomiphene citrate tablets USP. A low dosage or duration of treatment course is particularly recommended if unusual sensitivity to pituitary gonadotropin is suspected, such as in patients with polycystic ovary syndrome (see WARNINGS; Ovarian Hyperstimulation Syndrome ).

The patient should be evaluated carefully to exclude pregnancy, ovarian enlargement, or ovarian cyst formation between each treatment cycle.

If progestin-induced bleeding is planned, or if spontaneous uterine bleeding occurs prior to therapy, the regimen of 50 mg daily for 5 days should be started on or about the 5th day of the cycle. Therapy may be started at any time in the patient who has had no recent uterine bleeding. When ovulation occurs at this dosage, there is no advantage to increasing the dose in subsequent cycles of treatment.

If ovulation does not appear to occur after the first course of therapy, a second course of 100 mg daily (two 50 mg tablets given as a single daily dose) for 5 days should be given. This course may be started as early as 30 days after the previous one after precautions are taken to exclude the presence of pregnancy. Increasing the dosage or duration of therapy beyond 100 mg/day for 5 days is not recommended.

The majority of patients who are going to ovulate will do so after the first course of therapy. If ovulation does not occur after three courses of therapy, further treatment with Clomiphene citrate tablets USP is not recommended and the patient should be reevaluated. If three ovulatory responses occur, but pregnancy has not been achieved, further treatment is not recommended. If menses does not occur after an ovulatory response, the patient should be reevaluated. Long-term cyclic therapy is not recommended beyond a total of about 6 cycles (see PRECAUTIONS ).

How is Clomiphene Supplied

NDC 0591-0781-30: 50 mg tablets in cartons of 30

Tablets are round, white, scored, and debossed Watson over 781 .

Store tablets at controlled room temperature 59°-86°F (15°-30°C). Protect from heat, light, and excessive humidity, and store in closed containers.

Manufactured for: Watson Laboratories, Inc. Corona, CA 92880 USA

Manufactured by: Patheon Pharmaceuticals Inc. Cincinnati, OH 45215 USA

Revised: July 2013 70025264

PRINCIPAL DISPLAY PANEL

NDC: 0591-0781-30 Clomiphene Citrate Tablets USP 50 mg Watson Rx only Unit Dose - 30 Tablets

What Is Ciprapine Used For, Ciprapine

What is ciprapine used for?

Basic Idea: It is a very common mistake to say things like 'could of', 'should of', 'might of', or 'would of'. When talking with friends this isn't so bad, but in written Engl … ish or in more formal settings, it sounds very bad. You should say 'could have', should have', might have' or 'would have'. They can be abbreviated with 've when writing dialogue or when quoting someone, as in should've. The abbreviation is probably what leads to the 'of' error. In the cases above, the word have is a helping verb; it helps to clarify the verb's tense. "If I had known that you were coming, I would have baked a cake." At that past time, I did not know that you were coming. But if I HAD known [had is the past tense of have], if I could go back and change the past, I would have baked a cake. The word 'of' is never used to help express a verb's tense. Check the link for a helpful site on helping verbs! [NOTE: NOT for the faint of heart. If the above is enough, you should go to your next question.] You might ask if it would be ok to say "If I knew you were coming, I would have baked a cake." The difference is subtle. Saying "If I knew" implies that perhaps I knew, and perhaps I did not; it is unclear to me at this time whether or not I knew. And that might be exactly what you want to say. But if you are interested in the clearest language this leads to a logical conflict, doesn't it? It is unclear to me at this time whether or not I knew you were coming, but we can use the baking of a cake as a partial proof. If no cake was baked, then certainly I did not know you were coming. Assuming for a moment there was no cake, I am saying that I'm certain I did not know, but I'm expressing it with a verb that implies uncertainty. If a cake was baked, there is still ambiguity. "If I had known" implies that I in fact did not know, but would have taken action if I had. (MORE)

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"He" is a nominative Pronoun (Subjective) and "Him" is accussative pronoun (Objective) so subject always comes before verb and object always comes after verb. Thus … He is used as the subject of the sentence and him is used as the object of the sentence. He is eating an apple. (He-Subject) An apple is eaten by him. (Him - Object) (MORE)

21 people found this useful

Was is a simple past tense of the verb "to be" used with singular nouns as in "The boy was angry," meaning at some point in the past the male in question was angry. Were is th … e correct past tense form to use when addressing more than one subject as in "The boys were angry." Along with the noun, it helps establish whether the referent is singular or plural. (MORE)

Answer A general working rule is to remove the 'other person'. The sentence, 'You and I went to town' should make just as much sense when you remove the 'y … ou': 'I went to town'. If you had said, 'You and me went to town' then you would be left with, 'Me went to town,' which is obviously wrong! What about this: 'He brought cake for you and me' 'He brought cake for me' which is correct. 'He brought cake for you and I' 'He brought cake for I'. is incorrect. Make sense? (MORE)

You use 'an' before a vowel: - an apple, an orange - you use 'a' before a consonant: - a bridge, a spanner. You use the word 'a' if the word after it starts with a consonant ( … any letter in the alphabet except a, e, i, o and u) - for example; Johnny was playing with a ball. Johnny wanted a snack However, you use the 'an' if the word after it starts with a vowel (a, e, i, o or u) - for example; Johnny was playing with an animal. Johnny wanted an ice-cream (MORE)

Answered by The WikiAnswers ® Community

Making the world better, one answer at a time.

Present Perfect Tense: I have; You have; he, she, it has; we have, you have, they have Past Perfect Tense: I had; you had; he, she, it had; we had; you ha … d; they had Future Perfect Tense: I shall have; you will have; he, she, it will have; we shall have; you will have; they will have Note: has is used in the third person, singular present perfect tense. (MORE)

There is one B in the word about. There is one student in the class who answered all 20 questions correctly. There is is singular, agreeing with one B and one student. There … are twelve donuts in one dozen. There are many ways to make good pizza. TUse "there is" when the subject of the verb is singular and "there are" when the subject is plural. Sometimes there are grey areas. Crowd, group, class, tribe, audience. "The audience came to their feet" "The group discussed the matter among themselves". Sometimes there are grey areas. Crowd, group, class, tribe, audience. "The audience came to their feet" "The group discussed the matter among themselves". (MORE)

Buy Vera-Lich Verapamil Online Without Prescriptions, Vera-Lich

Calan (Vera-lich)

Calan is used for treating supraventricular tachycardia, a rhythm disturbance of the heart. It is also used for controlling heart rate response to other rhythm disturbances, specifically atrial fibrillation and atrial flutter. Calan is a calcium channel blocker. It works by slowing the electrical conduction in the heart, slowing heart rate, and/or normalizing heart rhythm.

Use Calan as directed by your doctor.

Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Do not crush, chew, break, or open Calan. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

Do not stop taking this medication without first talking to your doctor. If you stop taking Calan suddenly, your condition may become worse.

If you miss a dose of Calan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Calan.

Store Calan at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Calan out of the reach of children and away from pets.

Active Ingredient . Verapamil hydrochloride.

Do NOT use Calan if:

you are allergic to any ingredient in Calan

you have certain heart problems (eg, left ventricular dysfunction, sick sinus syndrome, second - or third-degree heart block and do not have a pacemaker), very low blood pressure, or moderate to severe congestive heart failure (CHF)

you have atrial fibrillation or flutter and a pre-excitation syndrome (extra conduction pathway in the heart), such as Wolff-Parkinson-White (WPW) syndrome or Lown-Ganong-Levine (LGL) syndrome

you have shock due to serious heart problems

you are taking dofetilide, or you have taken disopyramide within the past 48 hours.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Calan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have heart failure or a recent heart attack with lung congestion, low blood pressure, or heart problems (eg, a very slow heart rate, heart block, heart valve disease)

if you have kidney or liver problems, muscular dystrophy, or a neuromuscular disease

if you are taking another blood pressure medicine or you are being treated for cancer.

Some medicines may interact with Calan. Tell your health care provider if you are taking any other medicines, especially any of the following:

Beta-blockers (eg, propranolol), clonidine, disopyramide, ketolides (eg, telithromycin), macrolides (eg, erythromycin), or ritonavir because they may increase the risk of Calan's side effects

Phenobarbital, rifampin, or St. John's wort because they may decrease Calan's effectiveness

Aldosterone blockers (eg, eplerenone), aspirin, carbamazepine, colchicine, cyclosporine, digoxin, dofetilide, doxorubicin, dronedarone, eletriptan, erythromycin, everolimus, flecainide, HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), lithium, narcotic pain relievers (eg, fentanyl), paclitaxel, quinazolines (eg, terazosin), quinidine, ranolazine, theophyllines, or tolvaptan because the risk of their side effects may be increased by Calan.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Calan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Calan may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Calan with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Calan; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Calan may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Tell your doctor or dentist that you take Calan before you receive any medical or dental care, emergency care, or surgery.

Lab tests, including liver function, kidney function, complete blood cell counts, electrocardiogram (ECG), and blood pressure, may be performed while you use Calan. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Calan with caution in the elderly; they may be more sensitive to its effects.

Calan should not be used in childen; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Calan while you are pregnant. Calan is found in breast milk. If you are or will be breast-feeding while you use Calan, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Dizziness; fatigue; headache; lightheadedness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; lightheadedness, especially when standing; severe dizziness; shortness of breath; swelling of the feet or hands; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools, severe or persistent stomach pain, fever, general feeling of being unwell); unusually fast, slow, or irregular heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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