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Irbehasan Description

Irbehasan is a combination angiotensin II receptor blocker and diuretic. The angiotensin II receptor blocker works by relaxing the blood vessels. It helps the kidneys to eliminate fluid and sodium from the body.

Generic name of Irbehasan is Irbesartan/Hydrochlorothiazide.

Brand name of Irbehasan is Irbehasan.

Irbehasan Dosage

Irbehasan is available in:

150mg + 12.5mg Standard Dosage

Irbehasan may be taken with or without food.

It is recommended to drink extra fluids while you are taking Irbehasan.

Irbehasan may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.

If you want to achieve most effective results do not stop taking Irbehasan suddenly.

Irbehasan Missing of dose

Do not take double dose. If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule.

Irbehasan Overdose

If you overdose Irbehasan and you don't feel good you should visit your doctor or health care provider immediately.

Irbehasan Side effects

Irbehasan has its side effects. The most common are:

Less common but more serious side effects during taking Irbehasan:

allergy reactions (urticaria, breathing difficulties, rash, and eruption)chest painconfusiondecrease in sexual abilitydepressiondrowsinessfaintingfast or irregular heartbeatfever, chills, or persistent sore throatdecreased urinationhoarsenessmuscle paintenderness, or crampsred, swollen, blistered, or peeling skinrestlessnessseizuressevere or persistent dry mouthsevere or persistent vomitingshortness of breathswelling of the arms or legsunusual bruising or bleedingunusual thirstunusual tiredness or weaknessyellowing of the skin or eyes

Side effects manifestations are not only depend on medicine you are taking but also depend on your health state and on the other factors.

Irbehasan Contra-indications

Do not take Irbehasan if you are allergic to Irbehasan components.

Do not take Irbehasan if you're pregnant or you plan to have a baby, or you are a nursing mother.

Do not take Irbehasan if you have severe kidney problems or are unable to urinate.

Do not take Irbehasan if you are taking dofetilide or ketanserin.

Your risk of lightheadedness or fainting may be increased if you experience diarrhea, vomiting, excessive sweating, if you do not drink enough fluids, or if you are on a low-salt diet.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel normal.

Diabetes patients should be careful with Irbehasan because it may affect your blood sugar. Check blood sugar levels closely. Irbehasan may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. Be careful!

Irbehasan may interfere with certain lab tests, including parathyroid function tests.

Lab tests, including kidney function, blood pressure, and blood electrolytes, may be performed while you use Irbehasan. These tests may be used to monitor your condition or check for side effects.

Be careful with Irbehasan if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.

Be careful with Irbehasan if you have allergies to medicines, foods, or other substances.

Use Irbehasan with great care in case you want to undergo an operation (dental or any other).

Irbehasan can be not safety for children and elderly patients.

Try to be careful with sunbeams. Irbehasan makes skin sensitive to sunlight. Protect skin from the sun.

Avoid machine driving.

Do not stop taking Irbehasan suddenly.

Irbehasan Frequently asked questions

Q: What is Irbehasan?

A: Irbehasan is used for treating high blood pressure. It may also be used for other conditions. Irbehasan works by relaxing the blood vessels.

Q: How should I take Irbehasan?

A: Irbehasan is available in tablets (150 mg + 12.5 mg). Irbehasan may be taken with or without food. It is recommended to drink extra fluids while you are taking Irbehasan. Irbehasan may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm. If you want to achieve most effective results do not stop taking Irbehasan suddenly.

Q: What should I do in case of overdose?

A: Do not take Irbehasan tablets in large quantities. In case of Irbehasan overdosage, you need to visit doctor or health care provider immediately.

Q: What should I avoid while taking Irbehasan?

A: Avoid alcohol. Avoid machine driving.

Baby & Childhood Illness And Pain Relief, Calpo

Designed for mums and dads

Latest health advice

Always read the label.

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CALPOL ® Infant Suspension contains Paracetamol, can be used in infants from 2 months old (weighing over 4kg and not premature). CALPOL ® SIXPLUS™ Suspension and CALPOL ® SIXPLUS ™ Fastmelts contain Paracetamol, can be used in children from 6 years old. CALPROFEN ® Ibuprofen Suspension contains Ibuprofen, can be used in infants from 3 months old (weighing over 5Kg). CALCOUGH ® Infant Syrup contains Glycerol, can be used in infants from 3 months old. CALCOUGH ® Children's Soothing Syrup contains Glycerin & Liquid Sugar, can be used in children over one year old. CALGEL ® Teething Gel contains an anaesthetic and antiseptic, can be used in infants from 3 months. CALPOL ®. CALPROFEN ®. CALGEL ® and CALCOUGH ® are registered trademarks. SIXPLUS ™ is a trademark.

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This site is published by Johnson & Johnson Limited which is solely responsible for its contents. It is intended for a UK audience.

iPhone is a registered trademark of Apple Inc. registered in the U. S. and other countries. App Store is a service mark of Apple Inc.

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Share your story! Tell us how MediGuard has helped you or someone you love. Download the MediGuard Mobile App to manage your prescription and over-the-counter medications, for free. Taking multiple medications puts you at risk for possible drug-drug interactions Monitor the medical treatment of you and your loved ones.

DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

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Mycofug, Mycofug

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History

The innovative spirit that infuses PHILOMEDICA today can be traced back to pharmacist and natural scientist Dr. Norbert Gemsch. After the studies and researches with nobelist prof. Paul Karrer at the University ETH Zurich he proved scientifically the medical effectiveness of homeopathic complex drugs with their mechanism of impact and syntehtises in 1951. Lot of different products he developed for his own company GEMSCH & CO. and other famous drug giants. His creations PARAPIC, MULTIPLEX, MYCOFUG and ZUMBA were pioneer drugs and still build our core products.

After his death in 1965 his son-on-law Dr. Adolphe E. Fischer as an analytical chemist continued the focus on discovery and development of novel formulations especially for the international markets with their different requirements of the national medical authorities. New and innovative products as CONTRAPIC, YOMBA ORO, BIO-KAWA and many others completed the assortment of PHILOMEDICA which remained at the helm until end of 2013.

Since 2014 Diane N. Fischer his daughter arriving at PHILOMEDICA she reorganized and streamlined the company to reveal its strong entrepreneurial roots. She also has re-energized the company original mission for a fast and responsive, customer-focused way of doing business. Natural science knowhow, highly effective ingredients and outstanding quality produced in Switzerland keep being the focus of PHILOMEDICA's activities.

Today PHILOMEDICA mainly cares about medical and cosmetic products, biocide and food supplements in the sectors of dermatology, potency and dietetics. These fields of specialty medicine represent a most important and potential demand of the worldwide market. Our portfolio is large and many product launchings of are in process.

Copyright © Philomedica Ltd. All Rights Reserved.

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Anacin ohne rezept

Anacin is used for treating pain including, headache, muscle aches, sprains, tooth extraction and toothache, menstrual cramps, arthritis and rheumatism, and pain and fever of the common cold. It may also be used for other conditions as determined by your doctor.

Use Anacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Anacin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Taking it with food may not decrease the risk of stomach or bowel problems (eg, bleeding, ulcers) that may occur while taking Anacin.

Take Anacin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Anacin.

Use Anacin exactly as directed on the package, unless instructed differently by your doctor. If you are taking Anacin without a prescription, follow any warnings and precautions on the label.

If you miss a dose of Anacin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Anacin.

Store Anacin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Anacin out of the reach of children and away from pets.

Anacin may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Anacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate). This includes any medicines that contain caffeine.

Anacin has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Talk to your doctor before you take Anacin or other pain relievers/fever reducers if you drink more than 3 drinks with alcohol per day. Serious stomach ulcers or bleeding can occur with the use of Anacin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Anacin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Taking more than the recommended dose or taking Anacin regularly may be habit-forming.

Anacin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

Aspirin has been linked to a serious illness called Reye syndrome. Do not give Anacin to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.

Diabetes patients - Anacin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If Anacin has a strong vinegar-like smell upon opening, do not use. It means the medicine is breaking down. Throw the bottle away safely and out of the reach of children; contact your pharmacist and replace.

Tell your doctor or dentist that you take Anacin before you receive any medical or dental care, emergency care, or surgery.

Do not take Anacin for at least 7 days after any surgery unless directed by your health care provider.

Do not take Anacin for more than 10 days for pain or for more than 3 days for fever unless directed to do so by your health care provider.

Different brands of Anacin may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.

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Paris Hilton

About Paris Hilton

Born into wealth and the American equivalent of aristocracy, Paris Hilton was the oldest of Richard Hilton and Kathy Richards' four children, and an heir to the family's hotel chain (her great-grandfather, Conrad Hilton, was the founder). Growing up in New York and L. A. Paris, though she was often seen with celebrities, didn't become a household name until her ex-boyfriend Rick Salomon released a sex tape of theirs onto the Internet in 2003, shortly before her Fox reality show, The Simple Life, was set to air. The show, which filmed Paris and (former) best friend Nicole Richie as they tried to live on an Arkansas farm without the modern conveniences they were used to (credit cards, cell phones), became a hit, and almost instantly, Paris' name and image were everywhere. Paris, now famous for being famous, began dabbling in modeling, writing, movies, and of course, music. Drawing inspiration from the lighthearted, summertime pop of Gwen Stefani and Ashlee Simpson, the album's first single, "Stars Are Blind," was released in the spring of 2006, followed by her self-titled full-length debut in August, with plans for a follow-up already on the way.

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Born into wealth and the American equivalent of aristocracy, Paris Hilton was the oldest of Richard Hilton and Kathy Richards' four children, and an heir to the family's hotel chain (her great-grandfather, Conrad Hilton, was the founder). Growing up in New York and L. A. Paris, though she was often seen with celebrities, didn't become a household name until her ex-boyfriend Rick Salomon released a sex tape of theirs onto the Internet in 2003, shortly before her Fox reality show, The Simple Life, was set to air. The show, which filmed Paris and (former) best friend Nicole Richie as they tried to live on an Arkansas farm without the modern conveniences they were used to (credit cards, cell phones), became a hit, and almost instantly, Paris' name and image were everywhere. Paris, now famous for being famous, began dabbling in modeling, writing, movies, and of course, music. Drawing inspiration from the lighthearted, summertime pop of Gwen Stefani and Ashlee Simpson, the album's first single, "Stars Are Blind," was released in the spring of 2006, followed by her self-titled full-length debut in August, with plans for a follow-up already on the way.

Marisa Brown, Rovi

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Paris Hilton opts for an edgy look in black sequins with a jewel-embellished neckline and hemline at the 2012 MTV Movie Awards.

Paris Hilton's accessories at the 56th GRAMMY Awards at Staples Center on January 26, 2014 in Los Angeles, California.

Biography

Socialite Paris Whitney Hilton was born on February 17, 1981 in New York City, into the Hilton family, and has three younger siblings, Nicky Hilton Rothschild. Barron Hilton and Conrad Hilton. She is the daughter of Kathy Hilton (nee Kathleen Elizabeth Avanzino) and businessman Rick Hilton. and a great-granddaughter of hotel magnate Conrad Hilton. She has Italian (from a maternal great-grandfather), Irish, Norwegian, German, English, Scottish, and Welsh ancestry.

Hilton is heir-apparent to the vast Hilton hotel and real estate dynasty. Her childhood was spent in palatial dwellings in the priciest neighborhoods on both coasts and featured a brief flirtation with the educational system, including high schooling at the ultra-exclusive Dwight School, from which she dropped out and ultimately earned her high school GED.

Living the glitzy socialite life from a relatively early age, attending exclusive parties and being covered by the gossip press, Hilton apparently became hooked on obtaining celebrity status, which was perhaps furthered by the example of her mother, who had a brief acting career herself, mostly on TV. Hilton began a remarkable and well-financed campaign to put herself in the public eye, on screen, on television and in music. This effort has included a substantial amount of physical alteration. A naturally pleasant-looking girl, Hilton underwent extensive plastic surgery, hair coloring and tinted contact lenses in her attempt to reinvent herself as "hot". Sadly, money could not buy alteration of the physical attribute she most dislikes about herself: her exceptionally-large feet.

Some skeptics have guessed that the endless parade of inane inter-celebrity feuds centering around Hilton are, in fact, publicity stunts, another front in the campaign to keep her exposure level high. It has even been argued that the infamous home video of Hilton with then-boyfriend Rick Salomon. in which Hilton performs explicit romantic activities with Rick Salomon. was part of this campaign as well. If it was, it worked. For better or for worse, it made Hilton a household name overnight, and was even widely marketed as a video, 1 Night in Paris (2004).

Eventually Hilton's efforts paid off and she got some modeling work, the designers presumably relying on her notoriety. She has been an increasing presence on-screen too, in TV commercials, on TV series and in the movies, at first bit parts in movies such as Zoolander (2001), Wonderland (2003), The Cat in the Hat (2003) and guest-star roles on TV shows such as The O. C. (2003) and George Lopez (2002), but later more substantial roles in horror flick House of Wax (2005), the direct-to-DVD Bottoms Up (2006) and her own TV show, the fish-out-of-water reality series The Simple Life (2003).

Hilton also has plans to become a player in the music business, has recorded an album and even started her own music label, Heiress Records, in order to release it.

Hilton is widely scorned for what some see as her narcissism, shallow intellect and materialism and for other things besides, but she seems to be aware of the old adage that there's no such thing as bad publicity and it should be evident even to her detractors that she is ambitious and driven to achieve, rather than simply basking in her family's vast fortune, as do so many other socialites. In fact, performing is only part of her many activities and she has dabbled in designing, writing (one hastens to add, with a professional writer on the team), nightclub management and even marketing video games - all of which feature Paris Hilton, front and center.

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Onderon - Wookieepedia, Ondaron

Onderon

Affiliation

Onderon was a jungle world located within the Inner Rim. During the Clone Wars. the planetary government aligned itself with the Confederacy of Independent Systems ; in the Separatist Senate. Onderon was represented by Senator Mina Bonteri and later by her son, Lux Bonteri. In response to this political posture, a rebel cell on Onderon, led by siblings Steela and Saw Gerrera. formed with aid from the Jedi. This band of rebels excised the Separatist occupation from the planet, opening the door to joining the Galactic Republic. When Supreme Chancellor Sheev Palpatine transformed the Republic into the Galactic Empire and declared himself Emperor. the planet was taken over by the Imperials. This gave the rebirth of the Onderon rebels once more, now led solely by Saw Gerrera.

Contents

History Edit

In its earliest ages of civilization, Onderon was a world marked with savage jungles that were filled with dangerous creatures. To survive, the primitive human inhabitants of the planet protected themselves behind the walls of fortified settlements. Over time, these settlements grew to become enormous walled cities, including the planet's capital, Iziz. [4]

Clone Wars Edit

In the years after the Invasion of Naboo. the political idealist Count Dooku spread political turmoil on the world along with a host of others across the galaxy such as Sullust. [8] During the time of the Clone Wars. the planet's monarch King Sanjay Rash allied Onderon with the Confederacy of Independent Systems. However, many Onderonians refused to recognize the legitimacy of Sanjay's rule, as they preferred the neutral stance championed by former monarch Ramsis Dundup. This opposition led to the formation of the Onderon rebels. a group of freedom-fighters organized by Jedi Knight Anakin Skywalker. [4]

Led by Anakin, a contingent from the Republic, including Ahsoka Tano. Obi-Wan Kenobi. and Captain Rex. helped secretly train and arm the rebels to fight against the Separatist Droid Army. Forced to hide out in the jungles of Onderon, the rebels trained how to take down droids and tanks with the help of EMP grenades. However, in the midst of the training the training camp was attacked by a droid battalion. The rebels, with the help of the Jedi, were able to defeat the droids with relative ease. Now battle-tested, the rebels felt ready to infiltrate the capital city of Iziz.

Within Iziz, the rebels continued fighting against droids, covertly and systematically destroying droid patrols and checkpoints. Thinking these actions were led by the deposed King Dendup, King Sanjay Rash ordered the former king to stop the attacks. It soon became known that King Dendup was not in charge of the rebel attacks, frustrating King Rash.

Continuing the siege, the rebels were able to take out the droids' main power supply by hijacking one of the droid battle tanks. knocking out the power grid after a skirmish. These actions were brought to the attention of Count Dooku, who was displeased with Rash for not being able to quell the insurgents. Rash blamed the droids for this and asked for reinforcements. In response, the Count sent a Super tactical droid Kalani (super tactical droid) to win where Rash had failed. With the power supply down, the rebels were able to take down more and more droids quite easily with little resistance. Some time later the leader of the resistance, Steela Gererra. was able to send a message to the people of Iziz that their true king, Dendup, was silenced by King Rash and that they would take back their city.

This message concerned Rash, so he ordered the execution of the former king. This news made its way back to the insurgency. Steela's brother, Saw Gererra, decided to rescue the former king without help but was captured by the droids. He was then brought inside the palace for interrogation overseen by Kalani and General Tandin. Kalani intended to torture Saw to death but was stopped short by Tandin who believed the droid's tactics ineffective against stopping the rebels. However, the droid believed that Tandin merely pitied Gererra. Saw and the general spoke with each other, the general explaining how Gerarry was viewed as a terrorist, and how Tandin chose to stay free by going under the Separatists' rule. Saw viewed himself not as a terrorist, but as a freedom fighter trying to free his people from Separatist occupation.

At the public execution of King Dendup, the rebels attempted to free the king, but they were apprehended by droid reinforcements. General Tandin a witness to the rebels' capture, gathered the royal guard and freed the imprisoned rebels. The resistance fighters were able to escape while the general held king Rash as hostage. The general himself was held at gunpoint, so Ahsoka Tano jumped out of the crowd watching the execution and force pushed the droids away, stunning them. The two were able to escape from the droids with the people stopping the droids going after them. Now that the king Dendup was freed, the people were more rebellious against the droids and Rash's rule.

The rebels made their way to distant mountains, where they established a base of operations. Back in the city, Lux Bonteri and Ahsoka Tano showed the insurgency's last message, now by the king Ramsis Dendup. This message finally instigated mass action across the capital, causing riots and chaos in the city. Meanwhile droid scouts were able to locate the rebels' hideout in the eastern mountains. As Rash seemed helpless, Kalani assured him that with the death of both king Dendup and the rebellion, fear would bring order back to the people. He also sent additional reinforcements to assist the droid army, droid gunships.

As the droid army made their way to the mountains, the rebels at first were able to eliminate most of the droids very easily, but as the gunships arrived, the rebels were outgunned and outmatched very quickly. The battle seemed to lost and Ahsoka was ordered to retreat back to Coruscant by Obi-Wan Kenobi, reasoning sometimes people need to fight their own battles. Back on Coruscant, Anakin Skywalker did not accept the fact that the Republic should just ignore helping the rebels, so he travelled to Florrum to make a deal with Hondo Ohnaka. hiring him to illegally deliver rocket launchers to the rebels on Onderon.

During the battle, the rebels were dealing with heavy casualties from the new gunships, but the fight took a new turn when Hondo and couple of his pirates brought them the rocket launchers Anakin ordered. The rebels were able to take down the gunships with the help of the new weapons. Back in the base, commando droids discovered the king's hideout and almost killed him, but they were destroyed by Steela in time. At the same time, Saw and the rebels blew up the remaining two gunships, one of which crashed at the side of the mountain the king was on. As a result of the crash, the mountain broke down, leaving Steela hanging on the edge. Lux came to help but was knocked down as well. Bonteri was rescued by Ahsoka Tano. With Lux safe, Ahsoka focused her attention on Steela, and levitated Steela from the edge of the cliff. The crashed droid gunship was still marginally operational and shot a blast at Tano's shoulder, interrupting her Force grip. Steela fell to her death.

With Steela's sacrifice, the rebels rallied to defeat the droid army once and for all. Back in the city King Rash was desperate, demanding more reinforcements from Count Dooku. The Count was not pleased with his lack of control, and he ordered Kalani to regroup the remaining forces and bring them back to Agamar. The droid general executed Rash as a result of his failure, and retreated from Onderon.

With the Separatist army gone, Onderon was finally freed and joined the Galactic Republic. [1]

Age of the Empire Edit

The peace bought through sacrifice during the Clone Wars was not long lasting, as the Republic was reformed into the first Galactic Empire. With the Empire in control of the planet, a rule similar to the Separatist occupation was back again.

The Imperial rule caused insurgency groups to rise, led once again by Saw Gererra. Imperial Security Bureau Agent Kallus was tasked with tracking down and stamp out the rebels. His first stormtrooper unit was ambushed by a Lasat mercenary who was working for Saw Gererra. Kallus and the unit were caught in an explosion that knocked the ISB agent away. The Lasat slowly walked through the smoke and fire and killed every Imperial but Kallus, even the ones injured in the blast who were unable to defend themselves. [7]

Appearances Edit

Sources Edit

Notes and references Edit

Gris-Peg - Fda Prescribing Information, Side Effects And Uses, Gris-Peg

Gris-PEG

Gris-PEG ® Tablets contain ultramicrosize crystals of griseofulvin, an antibiotic derived from a species of Penicillium .

The chemical name of griseofulvin, USP is 7 - Chloro - 2’,4,6 - trimethoxy - 6’β - methylspiro[benzofuran - 2(3H),1’ - [2]cyclohexene] - 3,4’ - dione. Its structural formula is:

C 17 H 17 ClO 6 M. W. 352.77

Griseofulvin, USP occurs as a white to creamy white, odorless powder which is very slightly soluble in water, soluble in acetone, dimethylformamide, and chloroform and sparingly soluble in alcohol.

Each Gris-PEG tablet contains:

griseofulvin ultramicrosize. 125 mg

Inactive Ingredients: Polyethylene Glycol 8000, Lactose Monohydrate, Colloidal Silicon Dioxide, Crospovidone, Magnesium Stearate, Methylparaben, Polyvinyl Alcohol, Titanium Dioxide, Polyethylene Glycol 3350, and Talc.

Active Ingredient: griseofulvin ultramicrosize. 250 mg

Inactive Ingredients: Polyethylene Glycol 8000, Magnesium Stearate, Sodium Lauryl Sulfate, Methylparaben, Polyvinyl Alcohol, Titanium Dioxide, Polyethylene Glycol 3350, and Talc.

Gris-PEG - Clinical Pharmacology

Microbiology

Griseofulvin is fungistatic with in vitro activity against various species of Microsporum, Epidermophyton and Trichophyton. It has no effect on bacteria or other genera of fungi.

Pharmacokinetics

Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.

The efficiency of gastrointestinal absorption of ultramicrocrystalline griseofulvin is approximately one and one-half times that of the conventional microsize griseofulvin. This factor permits the oral intake of two-thirds as much ultramicrocrystalline griseofulvin as the microsize form. However, there is currently no evidence that this lower dose confers any significant clinical differences with regard to safety and/or efficacy.

In a bioequivalence study conducted in healthy volunteers (N=24) in the fasted state, 250 mg ultramicrocrystalline griseofulvin tablets were compared with 250 mg ultramicrocrystalline griseofulvin tablets that were physically altered (crushed) and administered with applesauce. The 250 mg ultramicrocrystalline griseofulvin tablets were found to be bioequivalent to the physically altered (crushed) 250 mg ultramicro-crystalline griseofulvin tablets (See Table 1 ).

Table 1: Mean (± SD) of the Pharmacokinetic Parameters for Griseofulvin administered in applesauce as a Single Dose of Gris-PEG® 250-mg Tablets Uncrushed and Crushed to fasted Healthy Volunteers (N=24)

250 mg Ultramicrocrystalline Griseofulvin Tablets Unaltered

250 mg Ultramicrocrystalline Griseofulvin Tablets Physically Altered (Crushed and in Applesauce)

9023.71 (± 1911.5)

Indications and Usage for Gris-PEG

Gris-PEG (griseofulvin ultramicrosize) is indicated for the treatment of the following ringworm infections; tinea corporis (ringworm of the body), tinea pedis (athlete's foot), tinea cruris (ringworm of the groin and thigh), tinea barbae (barber's itch), tinea capitis (ringworm of the scalp), and tinea unguium (onychomycosis, ringworm of the nails), when caused by one or more of the following genera of fungi: Trichophyton rubrum, Trichophyton tonsurans, Trichophyton mentagrophytes, Trichophyton interdigitalis, Trichophyton verrucosum, Trichophyton megnini, Trichophyton gallinae, Trichophyton crateriform, Trichophyton sulphureum, Trichophyton schoenleini, Microsporum audouini, Microsporum canis, Microsporum gypseum and Epidermophyton floccosum. NOTE: Prior to therapy, the type of fungi responsible for the infection should be identified. The use of the drug is not justified in minor or trivial infections which will respond to topical agents alone. Griseofulvin is not effective in the following: bacterial infections, candidiasis (moniliasis), histoplasmosis, actinomycosis, sporotrichosis, chromoblastomycosis, coccidioidomycosis, North American blastomycosis, cryptococcosis (torulosis), tinea versicolor and nocardiosis.

Contraindications

Two cases of conjoined twins have been reported since 1977 in patients taking griseofulvin during the first trimester of pregnancy. Griseofulvin should not be prescribed to pregnant patients. If the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. This drug is contraindicated in patients with porphyria or hepatocellular failure and in individuals with a history of hypersensitivity to griseofulvin.

Warnings

Prophylactic Usage

Safety and efficacy of griseofulvin for prophylaxis of fungal infections have not been established.

Serious Skin Reactions

Severe skin reactions (e. g. Stevens-Johnson syndrome, toxic epidermal necrolysis) and erythema multiforme have been reported with griseofulvin use. These reactions may be serious and may result in hospitalization or death. If severe skin reactions occur, griseofulvin should be discontinued (see ADVERSE REACTIONS section).

Hepatotoxicity

Elevations in AST, ALT, bilirubin, and jaundice have been reported with griseofulvin use. These reactions may be serious and may result in hospitalization or death. Patients should be monitored for hepatic adverse events and discontinuation of griseofulvin considered if warranted (see ADVERSE REACTIONS section).

Animal Toxicology

Chronic feeding of griseofulvin, at levels ranging from 0.5%-2.5% of the diet resulted in the development of liver tumors in several strains of mice, particularly in males. Smaller particle sizes result in an enhanced effect. Lower oral dosage levels have not been tested. Subcutaneous administration of relatively small doses of griseofulvin once a week during the first three weeks of life has also been reported to induce hepatomata in mice. Thyroid tumors, mostly adenomas but some carcinomas, have been reported in male rats receiving griseofulvin at levels of 2.0%, 1.0% and 0.2% of the diet, and in female rats receiving the two higher dose levels. Although studies in other animal species have not yielded evidence of tumorigenicity, these studies were not of adequate design to form a basis for conclusion in this regard. In subacute toxicity studies, orally administered griseofulvin produced hepatocellular necrosis in mice, but this has not been seen in other species. Disturbances in porphyrin metabolism have been reported in griseofulvin-treated laboratory animals. Griseofulvin has been reported to have a colchicine-like effect on mitosis and cocarcinogenicity with methylcholanthrene in cutaneous tumor induction in laboratory animals. Usage in Pregnancy – see CONTRAINDICATIONS section.

Animal Reproduction Studies

It has been reported in the literature that griseofulvin was found to be embryotoxic and teratogenic on oral administration to pregnant rats. Pups with abnormalities have been reported in the litters of a few bitches treated with griseofulvin. Suppression of spermatogenesis has been reported to occur in rats, but investigation in man failed to confirm this.

Precautions

Patients on prolonged therapy with any potent medication should be under close observation. Periodic monitoring of organ system function, including renal, hepatic and hematopoietic, should be done. Since griseofulvin is derived from species of Penicillium. the possibility of cross-sensitivity with penicillin exists; however, known penicillin-sensitive patients have been treated without difficulty. Since a photosensitivity reaction is occasionally associated with griseofulvin therapy, patients should be warned to avoid exposure to intense natural or artificial sunlight. Occasionally slight abnormalities in liver enzymes (irrespective of drug relationship) were reported with an incidence of less than 1%, specifically elevated ALT and/orAST. The majority of subjects with elevated liver enzymes also had concomitant medical conditions and were taking other drugs that may have increased the propensity for elevated values. When follow-up was provided, changes in elevated liver enzymes appeared to be reversible. Lupus erythematosus or lupus-like syndromes have been reported in patients receiving griseofulvin. Griseofulvin decreases the activity of warfarin-type anticoagulants so that patients receiving these drugs concomitantly may require dosage adjustment of the anticoagulant during and after griseofulvin therapy. Barbiturates usually depress griseofulvin activity and concomitant administration may require a dosage adjustment of the antifungal agent. There have been reports in the literature of possible interactions between griseofulvin and oral contraceptives. The effect of alcohol may be potentiated by griseofulvin, producing such effects as tachycardia and flush.

Adverse Reactions

There have been post-marketing reports of severe skin and hepatic adverse events associated with griseofulvin use (see WARNINGS section). When adverse reactions occur, they are most commonly of the hypersensitivity type such as skin rashes, urticaria, erythema multiforme-like drug reactions, and rarely, angioneurotic edema, and may necessitate withdrawal of therapy and appropriate countermeasures. Paresthesia of the hands and feet have been reported after extended therapy. Other side effects reported occasionally are oral thrush, nausea, vomiting, epigastric distress, diarrhea, headache, fatigue, dizziness, insomnia, mental confusion, and impairment of performance of routine activities. Proteinuria and leukopenia have been reported rarely. Administration of the drug should be discontinued if granulocytopenia occurs. When rare, serious reactions occur with griseofulvin, they are usually associated with high dosages, long periods of therapy, or both.

To report SUSPECTED ADVERSE REACTIONS, contact Valeant Pharmaceuticals North America LLC at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www. fda. gov/medwatch.

Gris-PEG Dosage and Administration

Accurate diagnosis of infecting organism is essential. Identification should be made either by direct microscopic examination of a mounting of infected tissue in a solution of potassium hydroxide or by culture on an appropriate medium. Medication must be continued until the infecting organism is completely eradicated as indicated by appropriate clinical or laboratory examination. Representative treatment periods are tinea capitis, 4 to 6 weeks; tinea corporis, 2 to 4 weeks; tinea pedis, 4 to 8 weeks; tinea unguium-depending on rate of growth-fingernails, at least 4 months; toenails, at least 6 months. General measures in regard to hygiene should be observed to control sources of infection or reinfection. Concomitant use of appropriate topical agents is usually required, particularly in treatment of tinea pedis. In some forms of athlete's foot, yeasts and bacteria may be involved as well as fungi. Griseofulvin will not eradicate the bacterial or monilial infection. Gris-PEG ® tablets may be swallowed whole or crushed and sprinkled onto 1 tablespoonful of applesauce and swallowed immediately without chewing.

Adults:

Daily administration of 375 mg (as a single dose or in divided doses) will give a satisfactory response in most patients with tinea corporis, tinea cruris, and tinea capitis. For those fungal infections more difficult to eradicate, such as tinea pedis and tinea unguium, a divided dose of 750 mg is recommended.

Pediatric Use:

Approximately 7.3 mg per kg of body weight per day of ultramicrosize griseofulvin is an effective dose for most pediatric patients. On this basis, the following dosage schedule is suggested:

16-27 kg: 125 mg to 187.5 mg daily

over 27 kg: 187.5 mg to 375 mg daily

Children and infants 2 years of age and younger – dosage has not been established. Clinical experience with griseofulvin in children with tinea capitis indicates that a single daily dose is effective. Clinical relapse will occur if the medication is not continued until the infecting organism is eradicated.

How is Gris-PEG Supplied

Gris-PEG ® (griseofulvin ultramicrosize) Tablets, 125 mg, white scored, elliptical-shaped, embossed “Gris-PEG” on one side and “125” on the other. The 125 mg strength is film-coated and is available in bottles of 100 (NDC 0884-0763-04).

Gris-PEG (griseofulvin ultramicrosize) Tablets, 250 mg, white scored, capsule-shaped, embossed “Gris-PEG” on one side and “250” on the other. The 250 mg strength is film-coated and is available in bottles of 100 (NDC 0884-0773-04).

STORAGE

Store Gris-PEG tablets at controlled room temperature 15° to 30°C (59° to 86°F) in tight, light-resistant containers.

Valeant Pharmaceuticals North America LLC

Bridgewater, NJ 08807 USA

Valeant Pharmaceuticals International, Inc.

Laval, Quebec, Canada, H7L 4A8

Gris-PEG is a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates.

© Valeant Pharmaceuticals North America LLC

PACKAGE LABEL – PRINCIPAL DISPLAY PANEL – 125 mg 100 count NDC 0884-0763-04 Rx only Gris-PEG ® (griseofulvin ultramicrosize) Tablets, USP 125 mg 100 Tablets VALEANT

PACKAGE LABEL – PRINCIPAL DISPLAY PANEL – 250 mg 100 count

NDC 0884-0773-04 Rx only Gris-PEG ® (griseofulvin ultramicrosize) Tablets, USP 250 mg 100 Tablets VALEANT

Iis 8, Dapril

The resource you are looking for has been removed, had its name changed, or is temporarily unavailable.

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Lovette, Lovette

Lovette

Awards 1997 Nightmoves Award – Best New Starlet The tiny blonde, buxom bombshell Lovette is a South Bend, Indiana native, born on January 27th, 1973. When she finally pursued the Adult Industry in 1995, she took it by storm. There wasn’t a magazine without her beautiful form on the front cover; Score, D-Cup, Score Xtra, and Gent just to name a few. The world was beholden to all of her “firsts”, which were captured on camera from girl-girl scenes to anal penetration. She also received the award, Best Anal Sex Scene . for her role and portrayal in ’Sex Freaks’. Even with all the success she’s attained during her career, she’s still maintained a down-to-Earth personality with a great sense of humor. Currently she is pursuing a career as a nurse, and hopefully she’ll find as much success there as she has in the XXX industry!

Partners & Investors - The Detrusan Value Proposition, Detrusan

Detrusan Value Proposition:

Detrusan is a proven neuromodulation technology that is minimally invasive and has been clinically shown to restore bladder muscle function in over 500 patients in hospitals in the US. The technology constitutes a compelling proposition for all Urinary Incontinence stakeholders.

For patients, it offers the opportunity of real and lasting relief from this difficult and often embarrassing condition with a therapy that enhances patient outcomes without side effects.

For doctors, it is an opportunity to effectively treat this stubborn condition and to positively enhance patient outcomes without known side effects.

For investors and other commercial partners, it is an opportunity to assist in bringing a clinically proven technology to a market of 50 million people whose clinical needs are currently unment.

Clinical Partners:

Medergie are actively seeking clinical partners that specialize in the areas of urogynecology, gynaecology or urology. If you are a potential clinical partner and are interested in learning more about the Detrusan value proposition, please contact us at: info@medergie. com

Investment / Commercial Partners:

If you are an investor or other commercial partner and are interested in helping us to deliver our revolutionary technology to the 50 million sufferers in the developed world whose clinical needs are currently unmet, please visit our corporate site www. medergie. com or contact us at: info@medergie. com

Frenagial 1 G Comprimidos Efervescentes Para Que Sirve, Frenagial

FRENAGIAL 1 g COMPRIMIDOS EFERVESCENTES

Prospecto e indicaciones

Lea todo el prospecto detenidamente porque contiene informacion importante para usted Este medicamento puede obtenerse sin receta, para el tratamiento de afecciones menores sin la intervencion de un medico. No obstante, debe usted utilizar con cuidado FRENAGIAL 1 g comprimidos efervescentes para obtener los mejores resultados. . Si necesita informacion adicional o consejo, consulte a su farmaceutico. Si los sintomas empeoran o si persiste la fiebre despues de 3 dias, o el dolor despues de 10 dias en adultos, debe consultar a un medico. En este prospecto . 1. Que es FRENAGIAL 1 g comprimidos efervescentes y para que se utiliza 2. Antes de tomar FRENAGIAL 1 g comprimidos efervescentes 3. Como tomar FRENAGIAL 1 g comprimidos efervescentes 4. Posibles efectos adversos 5. Conservacion de FRENAGIAL 1 g comprimidos efervescentes FRENAGIAL 1 g comprimidos efervescentes Paracetamol Cada comprimido efervescente contiene: 1 g de paracetamol como principio activo. Los demas componentes (excipientes) son: acido citrico anhidro, hidrogenocarbonato de sodio, carbonato de sodio anhidro, sacarina sodica, estearato de magnesio, Macrogol 6000, benzoato de sodio y acido adipico. Titular es: MCNEIL CONSUMER HEALTHCARE, S. L.U. P? de las Doce Estrellas, 5-7 28042 - MADRID El responsable de la fabricacion de este medicamento es: LUSOMEDICAMENTA SOCIEDADE TECNICA FARMACEUTICA, S. A. Estrada Consiglieri Pedroso, 69. Queluz de Baixo (Barcarena) - 2730-055 - Portugal 1. QUE ES FRENAGIAL 1g comprimidos efervescentes Y PARA QUE SE UTILIZA Son comprimidos efervescentes. Se presentan en tubos, cada envase contienen 12 comprimidos efervescentes para administracion oral. Esta indicado para el alivio sintomatico de los dolores ocasionales leves o moderados, como dolores de cabeza, dolores dentales. Estados febriles. El paracetamol es eficaz para reducir el dolor y la fiebre. 2. ANTES DE TOMAR FRENAGIAL 1g comprimidos efervescentes No tome FRENAGIAL 1g comprimidos efervescentes si: - Tiene alergia al paracetamol o a cualquiera de los componentes del medicamento. - Padece alguna enfermedad del higado. Tenga especial cuidado con FRENAGIAL 1g comprimidos efervescentes: • No se debe exceder la dosis recomendada en el apartado 3 COMO TOMAR FRENAGIAL 1 g comprimidos efervescentes • En pacientes alcoholicos cronicos, se debera tener la precaucion de no tomar mas de 2 g/dia de paracetamol. • En pacientes con enfermedades de rinon. del corazon o del pulmon y en pacientes con anemia, se debera consultar con el medico antes de tomar este medicamento. Toma de FRENAGIAL 1 g comprimidos efervescentes con los alimentos y bebidas: La utilizacion de paracetamol en pacientes que consumen habitualmente alcohol (tres o mas bebidas alcoholicas - cerveza, vino, licor. - al dia) puede provocar dano en el higado. Embarazo Consulte a su medico o farmaceutico antes de tomar un medicamento. Importante para la mujer Si esta usted embarazada o cree que pudiera estarlo, consulte a su medico antes de tomar este medicamento. El consumo de medicamentos durante el embarazo puede ser peligroso para el embrion o para el feto, y debe ser vigilado por su medico. MINISTERIO DE SANIDAD, POLITICA SOCIAL E IGUALDAD Agencia espanola de medicamentos y productos sanitarios Lactancia Consulte a su medico o farmaceutico antes de tomar un medicamento. El paracetamol pasa a la leche materna, por lo que las mujeres en periodo de lactancia deben consultar al medico antes de utilizar este medicamento. Uso en ninos y adolescentes: No utilizar en menores de 18 anos Conduccion y uso de maquinas . No se ha descrito ningun efecto en este sentido. Informacion importante sobre algunos de los componentes de Frenagial 1 g comprimidos efervescentes: Este medicamento contiene 480 mg de sodio por comprimido efervescente, lo que debe de ser tenido en cuenta en pacientes con dietas pobres en sodio.

Uso de otros medicamentos

Informe a su medico o farmaceutico si esta usando o ha usado recientemente cualquier otra medicacion, incluso los adquiridos sin receta medica, homeopaticos, plantas medicinales y otros productos relacionados con la salud. En particular si esta utilizando algunos de los siguientes medicamentos puede ser necesario modificar la dosis de algunos de ellos o la interrupcion del tratamiento: - Antibioticos (cloranfenicol) - Anticoagulantes orales (acenocumarol, warfarina) - Anticonceptivos orales y tratamientos con estrogenos - Antiepilepticos (lamotrigina, fenitoina u otras hidantoinas, fenobarbital, metilfenobarbital, primidona, carbamacepina) - Antituberculosos (isoniazida, rifampicina) - Barbituricos (utilizados como hipnoticos, sedantes y anticonvulsivantes) - Colestiramina (utilizado para disminuir los niveles de colesterol en sangre) - Medicamentos utilizados para el tratamiento de la gota (antigotosos)( probenecid y sulfinpirazona) - Algunos medicamentos utilizados para aumentar la eliminacion de orina (diureticos del asa como los del grupo furosemida) - Medicamentos usados para el alivio de espasmos o contracciones de estomago, intestino y vejiga (anticolinergicos) - Medicamentos utilizados para el corazon (glucosidos digitalicos) - Metoclopramida y domperidona (utilizados para evitar las nauseas y los vomitos) - Propranolol utilizado en el tratamiento de la tension arterial alta (hipertension) y las alteraciones del ritmo del corazon (arritmias cardiacas) - Zidovudina (utilizada en el tratamiento de los pacientes infectados por el virus de la inmunodeficiencia humana, causante del SIDA) Tampoco debe utilizarse con otros analgesicos (medicamentos que disminuyen el dolor) sin consultar con su medico. Interferencias con pruebas de diagnostico: Si le van a hacer alguna prueba diagnostica (analisis de sangre, orina, etc…) comunique a su medico que esta en tratamiento con FRENAGIAL 1 g comprimidos efervescentes ya que puede alterar los resultados. 3. COMO TOMAR FRENAGIAL 1 g comprimidos efervescentes Siga estas instrucciones a menos que su medico le haya dado otras indicaciones distintas. VIA ORAL Adultos: 1 comprimido cada 6 u 8 horas (3 o 4 veces al dia). La dosis maxima diaria sera de 4 comprimidos y debe dejarse un tiempo minimo entre cada toma de 6 horas. Pacientes con enfermedades del higado o del rinon: deben de consultar a su medico. Para la correcta administracion disuelva totalmente el comprimido efervescente en medio vaso de agua. No ingerir hasta que haya cesado completamente el burbujeo Usar siempre la dosis menor que sea efectiva. Si estima que la accion de FRENAGIAL 1 g comprimidos efervescentes es demasiado fuerte o debil, comuniqueselo a su medico o farmaceutico. La administracion del preparado esta supeditada a la aparicion de los sintomas dolorosos o febriles. A medida que estos desaparezcan, debe de suspenderse esta medicacion. Si el dolor se mantiene durante mas de 10 dias, la fiebre durante mas de 3 dias o bien el dolor o la fiebre empeoran o aparecen otros sintomas, debe de interrumpirse el tratamiento y consulta a su medico. Si usted toma mas FRENAGIAL 1 g comprimidos efervescentes del que debiera: Debe consultar inmediatamente a su medico o farmaceutico. Si se ha ingerido una sobredosis, debe acudirse rapidamente a un centro medico aunque no haya sintomas, ya que a menudo estos no se manifiestan hasta pasados 3 dias desde la ingestion de la sobredosis, aun en casos de intoxicacion grave. Los sintomas de sobredosis pueden ser: mareos, vomitos, perdida de apetito, coloracion amarillenta de la piel y los ojos (ictericia) y dolor abdominal. MINISTERIO DE SANIDAD, POLITICA SOCIAL E IGUALDAD Agencia espanola de medicamentos y productos sanitarios El tratamiento de la sobredosis es mas eficaz si se inicia dentro de las 4 horas siguientes a la ingestion del medicamento. Los pacientes en tratamiento con barbituricos o los alcoholicos cronicos, pueden ser mas susceptibles a la toxicidad de una sobredosis de paracetamol. En caso de sobredosis o ingestion accidental, acudir inmediatamente a un centro medico o llamar al Servicio de Informacion Toxicologica (Telefono 91 562 04 20), indicando el medicamento y la cantidad ingerida. Si olvido tomar FRENAGIAL 1 g comprimidos efervescentes: No tome una dosis doble para compensar las dosis olvidadas. 4. POSIBLES EFECTOS ADVERSOS Como todos los medicamentos, FRENAGIAL 1 g comprimidos efervescentes puede tener efectos adversos. En raras ocasiones (en menos de 1 por cada 1.000 pacientes pero en mas de1 por cada 10.000), se pueden producir: Trastornos del rinon, orina turbia, dermatitis alergica, ictericia (coloracion amarillenta de la piel), alteraciones sanguineas (agranulocitosis, leucopenia, neutropenia, trombocitopenia, anemia hemolitica) e hipoglucemia (bajada de azucar en sangre). El paracetamol puede danar el higado cuando se toma en dosis altas o en tratamientos prolongados. Si se observa cualquier otra reaccion no descrita en este prospecto, consulte con su medico o farmaceutico 5. CONSERVACION DE FRENAGIAL 1 g comprimidos efervescentes Mantenga FRENAGIAL 1 g comprimidos efervescentes fuera del alcance y de la vista de los ninos. No conservar a temperatura superior a 30oC. Mantenga el tubo perfectamente cerrado. Caducidad No utilizar FRENAGIAL 1 g comprimidos efervescentes despues de la fecha de caducidad indicada en el envase. Este prospecto ha sido aprobado en Mayo 2006

ICTERICIA . Es la pigmentacion amarilla del blanco de los ojos o de la piel, provocada por un exceso de bilirrubina en la sangre que acaba depositandose en los tejidos.

VEJIGA . Es la parte del aparato urinario que almacena la orina.

Celexin, Celexin

Paraguay

CELEXIN

CATEDRAL

AntibiпїЅtico cefalosporпїЅnico-bactericida de amplio espectro.

ComposiciпїЅn.

CELEXIN 1g: cada comprimido contiene: cefalexina (monohidrato) 1g. Excipientes cs. CELEXIN CAPSULAS: cada cпїЅpsula contiene: cefalexina (monohidrato) 500mg. Excipientes cs. CELEXIN 250: cada 5ml de suspensiпїЅn reconstituida contiene: cefalexina (monohidrato) 250mg. Excipientes cs. CELEXIN 500: cada 5ml de suspensiпїЅn reconstituida contiene: cefalexina (monohidrato) 500mg. Excipientes cs. CELEXIN INYECTABLE: cada frasco ampolla con polvo liofilizado contiene: cefazolina sпїЅdica eq. a cefazolina base 1g. Cada ampolla solvente x 5ml contiene: agua bidestilada para inyectables 5ml.

Indicaciones.

CELEXIN ha demostrado una gran utilidad y versatilidad en el correcto tratamiento de las infecciones bacterianas moderadas y/o severas de diversas localizaciones, tales como: tracto respiratorio: ocasionados por Diplococcus pneumoniae; Klebsiella; Haemophilus influenzae; Staphylococcus aureus; Streptococcus alfa y betahemolпїЅticos. Tracto genitourinario: Escherichia coli; Proteus mirabilis; Klebsiellas; enterobacteriпїЅceas y Enterococcus. Piel y tejidos blandos: Staphylococcus aureus; Streptococcus y otras cepas. Tejido пїЅseo y articulaciones: septicemia y endocarditis.

DosificaciпїЅn.

VпїЅa oral: cпїЅpsulas-comprimidos: 1 cпїЅpsula de 500mg o 1 comprimido de 1g cada 6 u 8 horas segпїЅn severidad del cuadro infeccioso. SuspensiпїЅn extemporпїЅnea: 250mg/5ml y 500mg/5ml: 50-100mg/kg/dпїЅa en dosis repartidas cada 6 u 8 horas. VпїЅa parenteral: IM-IV-fleboclisis: niпїЅos: 50 a 100mg/kg/dпїЅa en dosis repartidas cada 8 o 12 horas. Adultos: 1g cada 8 o 12 horas. La dosis puede aumentarse hasta 1,2g/dпїЅa, segпїЅn criterio mпїЅdico. InstrucciпїЅn para la preparaciпїЅn de la suspensiпїЅn extemporпїЅnea: agitar el polvo del frasco, agregar agua hasta alcanzar el nivel indicado, agitar enпїЅrgicamente, luego completar con agua hasta alcanzar nuevamente el nivel indicado. Una vez reconstituida la suspensiпїЅn puede conservarse por 7 dпїЅas en lugar fresco o en la heladera. Agitar el frasco antes de cada toma.

Contraindicaciones.

EstпїЅ contraindicado en pacientes con demostrada hipersensibilidad a las cefalosporinas. Puede presentarse reacciпїЅn cruzada en pacientes alпїЅrgicos a la penicilina.

Reacciones adversas.

Trastornos gastrointestinales, raramente nпїЅuseas, vпїЅmitos y colitis seudomembranosa, mпїЅs frecuentemente diarrea, dolor abdominal, dispepsia, gastritis. Hipersensibilidad, rash, urticaria y raramente eritema multiforme, sпїЅndrome de Stevens-Johnson, anafilaxia.

Precauciones.

Antes de indicar CELEXIN deben investigarse reacciones de hipersensibilidad previa a las cefalosporinas o penicilinas. El tratamiento con antibiпїЅticos de amplio espectro puede alterar la flora del colon y permitir el crecimiento del Clostridium difficile cuya toxina produce diarrea asociada con colitis seudomembranosa. Se han informado pruebas de Coombs positivas. Debe ser administrado con cuidado en presencia de insuficiencia renal. Con el uso de la cefalexina/cefazolina puede encontrarse reacciпїЅn de glucosa en orina con resultado falso positivo en las pruebas realizadas con sulfato de cobre.

Interacciones.

Puede inhibir la sпїЅntesis de vitamina K al suprimir la flora intestinal. Con diurпїЅticos de asa: potenciaciпїЅn de la nefrotoxicidad, especialmente en pacientes con disfunciпїЅn renal.

SobredosificaciпїЅn.

En caso de sobredosis recurrir al Centro Nacional de ToxicologпїЅa en el Centro de Emergencias MпїЅdicas Dr. Luis M. ArgaпїЅa, Av. Gral. Santos y Teodoro S. MongelпїЅs, Tel. 204-800 - 206-203.

PresentaciпїЅn.

CELEXIN CпїЅpsulas: caja x 8 y 16. CELEXIN 1g Comprimidos: caja x 10. CELEXIN SuspensiпїЅn extemporпїЅnea: frasco con polvo para reconstituir: 250mg/5ml: frasco x 50ml; 250mg/5ml: frasco x 100ml; 500mg/5ml: frasco x 100ml. CELEXIN Inyectable: 1 frasco ampolla + solvente x 5ml.

Beclosil, Beclosil

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Cedantron Tablet - Situs Nama Obat, Cedantron

Sembelit/susah buang air besar, sakit kepala, perasaan panas atau hangat di kepala & ulu hati.

INDEKS KEAMANAN PADA WANITA HAMIL

Baik penelitian reproduksi hewan tidak menunjukkan risiko pada janin maupun penelitian terkendali pada wanita hamil atau hewan coba tidak memperlihatkan efek merugikan (kecuali penurunan kesuburan) dimana tidak ada penelitian terkendali yang mengkonfirmasi risiko pada wanita hamil semester pertama (dan tidak ada bukti risiko pada trisemester selanjutnya).

Tablet 8 mg x 10 biji.

Pencegahan mual dan muntah setelah operasi. diawali dengan 1 tablet 1 jam sebelum pembiusan, dilanjutkan dengan 2 dosis sebesar 1 tablet tiap 8 jam.

Mual dan muntah akibat radioterapi. 8 mg tiap 8 jam.

Dosis pertama harus diberikan 1-2 jam sebelum radioterapi.

Feminac 35, Feminac 35

Cyproterone/Ethinyl Estradiol Feminac 35 (CH)

Brand names

US: CAN: Cyestra-35, Diane-35®, Novo-Cyproterone/Ethinyl Estradiol INT: Show/Hide Althea (PH), Ancea (PH), Ariane (PH), Axira (HR), Bellune (HR), Ciprane (BR), Clairette (KR), Claudia (BE), Climene (DO), Cybelle (PH), Cypestra-35 (CH), Cypress (MY, TH), Dafne 35 (TH), Daphne (BE), Diane (AT, BE, EE, FI, IN, MX, NO, RU, SE, TR, VN), Diane 35 (AR, BG, BR, CH, CL, CR, CZ, DK, DO, EC, EE, EG, FR, GT, HK, HN, HR, ID, IL, KR, MY, NI, PA, PE, PH, PK, PY, RO, SG, SI, SK, SV, TH, TW), Diane 35 Diario (ES), Diane Mite (IS), Diane-35 (AE, BB, BH, BM, BS, BZ, CO, GY, JM, JO, KW, LB, NL, PR, QA, SA, SR, TT, UY, VE, ZA), Diane-35 ED (AU, NZ), Dianette (IE), Diva-35 (ZA), Dixi-35 (CL, PE, PY), Esdian (TW), Estelle -35 (IL, MY, SG, TW), Estelle-35 (AE), Estelle-35 ED (AU, ID, NZ), Eunice-35 (MX), Evepar (FR), Facetik (CO), Femina-35 (EE), Feminac 35 (CH), Feminil (NO), Giane 35 (MY), Ginet-63 (NZ), Ginet-84 (NZ), Gynofen 35 (GR), Helen (TH), Holgyeme (FR), Jennifer 35 (DE), Juliet-35 ED (AU), Juliette (DE), Lady-E35 (TH), Lady-Ten 35 (CL), Laila-35 ED (AU), Linface (EC), Minerva-35 (ZA), Neynna (ID), Nortin (TW), OC-35 (TH), Sucee (MY), Tess (BR), Zyrona (SE)

Forms of this drug

Prescrire drugs to avoid

Anticholinergic burden

Beers criteria for older adults

Screening tool of older people's prescriptions (STOPP)

G3 Estrogens with a history of breast cancer Increased risk of recurrence

G4 Estrogens & history of venous thromboembolism Increased risk of recurrence

G5 Estrogens without progestogen in patients with intact uterus Risk of endometrial cancer

Black box warning

Cephorum 250mg Tablets For Dogs, Cephorum

Cephorum 250mg Tablets - 250mg

Please note images are for illustration purposes and may differ from the product(s) you receive

Off-white round biconvex film-coated tablets scored on one side with CX embossed above the score-line and 250 below the score-line. Each tablet contains cefalexin monohydrate Ph. Eur. Equivalent to 250 mg anhydrous cefalexin.

Cephorum Tablets 250 mg are indicated for oral antibiotic therapy in dogs. Cefalexin is a broad-spectrum cephalosporin antibiotic with bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria. The following have been shown to be sensitive to cefalexin in vitro: Staphylococcus spp (including penicillin-resistant strains), Streptococcus spp, Corynebacterium spp, Pasteur Ella multocida, Escherichia coli and Klebsiella spp.

When susceptible organisms are present, Cephorum Tablets 250 mg are indicated for the treatment of bacterial skin infections and urinary-tract infections caused by Klebsiella pneumonia.

Cephorum 250mg Tablets - 250mg

Please note images are for illustration purposes and may differ from the product(s) you receive

Off-white round biconvex film-coated tablets scored on one side with CX embossed above the score-line and 250 below the score-line. Each tablet contains cefalexin monohydrate Ph. Eur. Equivalent to 250 mg anhydrous cefalexin.

Cephorum Tablets 250 mg are indicated for oral antibiotic therapy in dogs. Cefalexin is a broad-spectrum cephalosporin antibiotic with bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria. The following have been shown to be sensitive to cefalexin in vitro: Staphylococcus spp (including penicillin-resistant strains), Streptococcus spp, Corynebacterium spp, Pasteur Ella multocida, Escherichia coli and Klebsiella spp.

When susceptible organisms are present, Cephorum Tablets 250 mg are indicated for the treatment of bacterial skin infections and urinary-tract infections caused by Klebsiella pneumonia.

Buy Kepakuru L - Nifedipine - Online Without Prescriptions, Kepakuru L

Adalat (Kepakuru l)

Adalat is used to treat hypertension (high blood pressure) and angina (chest pain). Adalat is in a class of drugs called calcium channel blockers. Adalat relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.

Take Adalat exactly as prescribed by your doctor.

Do not take in larger or smaller amounts or for longer than recommended.

Your doctor may occasionally change your dose to make sure you get the best results.

Take Adalat on an empty stomach. Do not crush, chew, or break a tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.

Do not stop taking Adalat even if you feel fine. Stopping suddenly may make your condition worse. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Your blood pressure will need to be checked often and you may need other blood tests at your doctor's office. Visit your doctor regularly.

If you miss a dose of Adalat, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Adalat.

Store Adalat at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Adalat out of the reach of children and away from pets.

Active Ingredient: Nifedipine.

you are allergic to any ingredient in Adalat.

Some medical conditions may interact with Adalat. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney or liver disease (especially cirrhosis), coronary artery disease, congestive heart failure, or digestive problems

if you have recently had or will be having surgery, or if you have recently stopped taking a beta-blocker (eg, propranolol).

Some medicines may interact with Adalat. Tell your health care provider if you are taking any other medicines, especially any of the following:

acarbose (Precose);

cimetidine (Tagamet);

fentanyl (Actiq, Duragesic, Fentora) or other narcotic pain medications;

digoxin (Lanoxin);

nefazodone;

St. John's wort;

rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate) or rifapentine (Priftin);

a blood thinner such as warfarin (Coumadin);

an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), or erythromycin (E. E.S. EryPed, Ery-Tab, Erythrocin);

antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Nizoral);

a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), timolol (Blocadren), and others;

a heart rhythm medication such as quinidine (Quin-G) or flecaininde (Tambocor);

HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), or ritonavir (Norvir, Kaletra, or saquinavir (Invirase);

medicines used to prevent organ transplant rejection, such as sirolimus (Rapamune) or tacrolimus (Prograf);

other heart or blood pressure medications such as benazepril (Lotensin), diltiazem (Cartia, Cardizem), doxazosin (Cardura), or verapamil (Calan, Covera, Isoptin, Verelan); or

seizure medication such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Solfoton), or phenytoin (Dilantin).

This list is not complete and other drugs may interact with Adalat. Tell your doctor about all medications you use.

Important safety information:

Adalat may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Adalat with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Proper dental care is important while you are taking Adalat. Brush and floss your teeth and visit the dentist regularly.

Use Adalat with caution in the elderly.

Adalat should not be used in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Adalat while you are pregnant. It is not known if Adalat is found in breast milk. If you are or will be breast-feeding while you use Adalat, check with your doctor. Discuss any possible risks to your baby.

Get emergency medical help if you have any of these signs of an allergic reaction to Adalat: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect while using Adalat such as:

worsening angina;

feeling like you might pass out;

feeling short of breath, swelling in your hands or feet;

fast or pounding heartbeats;

numbness or tingly feeling;

jaundice (yellowing of the skin or eyes); or

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

Less serious side effects may include:

headache, dizziness;

drowsiness, tired feeling;

nausea, constipation, diarrhea, stomach pain;

sleep problems (insomnia);

mild rash or itching;

joint pain, leg cramps;

warmth, redness, or tingly feeling under your skin; or

urinating more than usual.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Lovastatina (Mevacor, Lovinacor, Rextat, Tavacor) Effetti Collaterali, Controindicazioni, Posologia

Lovastatina (Mevacor, Lovinacor, Rextat, Tavacor): effetti collaterali, controindicazioni, posologia, dosaggio, indicazioni, dosi ed interazioni

Nome Generico . lovastatina Marchi . Mevacor, Lovinacor, Rextat, Tavacor Disponibilita . solo su prescrizione Categoria di Gravidanza: X . da non usare in gravidanza

Lovastatina e usato per:

Riduce il colesterolo in alcuni pazienti. Viene usato in concomitanza con una dieta appropriata. Viene usato in alcuni pazienti per ridurre il rischio di attacco di cuore e il dolore al petto causato dall ‘angina. Viene anche utilizzato per rallentare il blocco dei vasi sanguigni e riduce la necessita di interventi per aprire i vasi occlusi. Esso puo essere utilizzato anche per altre circostanze come determinato dal medico.

Lovastatina e un inibitore della HMG-CoA reduttasi, anche noti come “statine”. Agisce riducendo la produzione di alcune sostanze grasse da parte del corpo, compreso il colesterolo.

NON utilizzare lovastatina se:

e allergico a qualsiasi ingrediente di lovastatina

ha problemi al fegato o inspiegabilmente anormali risultati delle prove di funzionalita epatica

e incinta, puo rimanere incinta, o sta allattando al seno

sta assumendo alcuni antimicotici azolici (ad esempio, itraconazolo, ketoconazolo, posaconazolo), ciclosporina, gemfibrozil, antibiotici macrolidi (ad esempio alcune, claritromicina, eritromicina), mibefradil, mifepristone, nefazodone, inibitori della proteasi (ad esempio, boceprevir, ritonavir), o telitromicina

sta assumendo conivaptan o lo hanno preso negli ultimi 7 giorni

Rivolgersi al proprio medico o il fornitore di cure mediche subito se uno di questi si applicano a voi.

Prima di usare lovastatina:

Alcune condizioni mediche possono interagire con lovastatina. Informi il medico o il farmacista se avete qualunque condizioni mediche, soprattutto se una delle seguenti si applicano a voi:

se e incinta, sta pianificando una gravidanza o l’allattamento al seno

se si e in grado di rimanere incinta

se sta assumendo qualsiasi prescrizione o medicine senza ricetta medica, la preparazione a base di erbe, o del supplemento dietetico

Se avete allergie alle medicine, alimenti, o altre sostanze

se si ha la pressione bassa, problemi renali, il diabete, la funzione della tiroide bassa, problemi muscolari (ad esempio, dolore, debolezza), disturbi del metabolismo, problemi ormonali, o problemi di elettroliti

se si beve alcool o hanno una storia di convulsioni, problemi al fegato, o abuso di alcool

se si dispone di un certo tipo di colesterolo alto (ipercolesterolemia familiare omozigote)

se sono previsti per interventi di chirurgia maggiore, di recente intervento chirurgico maggiore o una lesione grave, o avere una grave infezione

se ha avuto un trapianto d’organo e sta assumendo un medicinale che sopprime una reazione di rigetto

Alcuni medicinali possono interagire con lovastatina. Dire al vostro fornitore di cure mediche se sta assumendo altri farmaci, in particolare uno dei seguenti:

Amiodarone, la colchicina, conivaptan, ciclosporina, danazolo, daptomicina, delavirdina, diltiazem, dronedarone, fibrati (es. gemfibrozil, fenofibrato), fluconazolo, voriconazolo, o altri antimicotici azolici (ad esempio, itraconazolo, ketoconazolo, posaconazolo), acido fusidico, imatinib; antibiotici macrolidi (ad esempio, claritromicina, eritromicina), mibefradil, mifepristone, nefazodone, niacina, gli inibitori della proteasi (ad esempio, boceprevir, ritonavir), ranolazina, streptogramine (ad esempio, dalfopristin), telitromicina, ticagrelor, o verapamil perche possono aumentare il rischio di lovastatina gli effetti collaterali, tra cui gravi problemi muscolari

Il bosentan, carbamazepina, erba di efavirenz, rifamicine (ad esempio, rifampicina), o di San Giovanni, perche puo diminuire l’efficacia di lovastatina

Anticoagulanti (ad esempio, warfarin), cimetidina, sirolimus, spironolattone, o tacrolimus perche il rischio dei loro effetti collaterali possono essere aumentate di lovastatina

Questo non puo essere un elenco completo di tutte le interazioni che possono verificarsi. Chiedete al vostro fornitore di assistenza sanitaria se lovastatina puo interagire con i farmaci che si stanno assumendo. Controllare con il vostro fornitore di assistenza sanitaria prima di iniziare, interrompere o modificare il dosaggio di qualsiasi medicinale.

Lovastatina Avvertenze Gravidanza

Lovastatina e stato assegnato alla gravidanza categoria X da parte della FDA. Gli studi sugli animali hanno rivelato evidenza di teratogenicita, tra cui un aumento dell’incidenza di malformazioni scheletriche. Non esistono dati controllati in donne in gravidanza. Tuttavia, gli inibitori della HMG-CoA reduttasi sono noti per inibire i processi biosintetici necessari nello sviluppo fetale. L’associazione VATER e stato riportato in un bambino esposto a lovastatina e dextroamphetamine durante l’organogenesi. Uso Lovastatina e considerato controindicato durante la gravidanza.

L’associazione VATER (anomalie vertebrali, atresia anale, fistola tracheo-esofagea con atresia esofagea, displasia renale e radiale) e stata riportata in una ragazza la cui madre ha ricevuto lovastatina 10 mg al giorno e dextroamphetamine 10 mg al giorno durante il primo trimestre di gravidanza per il trattamento di ipercolesterolemia e aumento di peso progressivo. Entrambi i farmaci sono stati sospesi cinque settimane dopo, a circa nove settimane di gestazione, quando la gravidanza e stata confermata.

Lovastatina Avvertenze allattamento

Non vi sono dati sull’escrezione di lovastatina nel latte umano. Il fabbricante ritiene lovastatina essere controindicato durante l’allattamento.

Come usare lovastatina:

Utilizzare lovastatina come indicato dal vostro medico. Controllare l’etichetta sul medicinale per esatte istruzioni per il dosaggio.

Prendere lovastatina per via orale con il cibo.

Mangiare pompelmo o bere succo di pompelmo puo aumentare la quantita di lovastatina nel sangue, che puo aumentare il rischio di gravi effetti collaterali. Il rischio puo essere maggiore con grandi quantita di pompelmo o succo di pompelmo. Evitare grandi quantita di succo di pompelmo o di pompelmo (ad esempio, piu di uno quarto di gallone britannico al giorno). Parlate con il vostro medico o il farmacista se avete domande su di includere pompelmo o succo di pompelmo nella vostra dieta mentre sta prendendo lovastatina.

Continuare a prendere lovastatina, anche se si sente bene. Da non perdere le dosi prescritte.

Se si dimentica una dose di lovastatina, prenda il piu presto possibile. Se e quasi ora per la dose successiva, salti la dose e tornare al normale orario di dosaggio. Non prendete 2 dosi in una volta.

Chiedete al vostro fornitore di cure mediche tutte le domande che potresti avere su come utilizzare lovastatina.

Importanti informazioni di sicurezza:

Lovastatina puo provocare capogiri o visione offuscata. Questi effetti possono essere peggiore se si prendono con l’alcol o di alcuni farmaci. Utilizzare con cautela lovastatina. Non guidi o svolgere altre attivita eventualmente pericolosi finche non si sa come reagire.

Lovastatina puo causare problemi al fegato. Raramente, problemi al fegato gravi e talvolta fatali sono stati riportati in pazienti in trattamento con statine “, tra cui” medicine lovastatina. Il rischio di sviluppare problemi al fegato puo essere maggiore se si beve alcol tutti i giorni o in grandi quantita con lovastatina o se avete una storia di problemi al fegato. Verificare con il proprio medico prima di bere alcool mentre sta assumendo lovastatina. Informi il medico immediatamente se si presentano sintomi di problemi al fegato (ad esempio, urine scure, feci pallide, nausea grave o persistente, perdita di appetito, o mal di stomaco, stanchezza, ingiallimento della pelle o degli occhi).

Seguire la dieta e il programma di esercizio dato a voi dal vostro fornitore di cure mediche.

Informi il medico o il dentista che si prende lovastatina prima di sottoporsi a cure mediche o dentarie, cure d’emergenza, o interventi chirurgici.

Le donne che possono rimanere incinta devono usare metodi di contraccezione durante il trattamento con lovastatina. Verificare con il proprio medico se avete domande sull’utilizzo di controllo delle nascite.

Non prenda piu della dose raccomandata, senza essersi consultato con il medico.

Problemi muscolari (miopatia) puo verificarsi con lovastatina. Relazione di dolori muscolari, tenerezza, o debolezza per il medico, soprattutto se si hanno anche febbre o malessere generale del corpo. Informi il medico se si hanno problemi muscolari che persistono anche dopo che il medico ha detto di interrompere l’assunzione di lovastatina.

I pazienti diabetici – Lovastatina possono influenzare il livello di zucchero nel sangue. Verificare i livelli di zucchero nel sangue da vicino. Chiedete al vostro medico prima di modificare la dose di medicina per il diabete.

Le prove di laboratorio, compresi i livelli di colesterolo nel sangue, funzione epatica, e creatina fosfochinasi (CPK) nel sangue i livelli, possono essere effettuati durante l’utilizzo lovastatina. Questi test possono essere utilizzati per monitorare la sua condizione o di controllo degli effetti collaterali. Essere sicuri di mantenere tutti i medici e gli appuntamenti di laboratorio.

Utilizzare lovastatina con cautela nei pazienti anziani e possono essere piu sensibili ai suoi effetti, i problemi muscolari particolarmente gravi.

Lovastatina deve essere usato con estrema cautela nei bambini di eta inferiore ai 10 anni e in quelli che non hanno raggiunto la puberta, la sicurezza e l’efficacia di questi bambini non sono state confermate.

Gravidanza e allattamento: Non usare lovastatina in caso di gravidanza. Essa puo causare danni al feto. Evitare la gravidanza mentre si sta prendendo. Se si pensa di poter essere incinta, contattare immediatamente il medico. Non e noto se lovastatina si trova nel latte materno. Non allattare al seno durante il trattamento con lovastatina.

Possibili effetti collaterali di lovastatina:

Tutti i farmaci possono causare effetti indesiderati, ma molte persone non hanno, o hanno minori effetti collaterali. Verificare con il proprio medico se uno qualsiasi di questi effetti indesiderati comuni piu persistono o diventano fastidiosi:

Rivolgersi ad un medico immediatamente se uno qualsiasi di questi effetti indesiderati gravi si verificano:

Gravi reazioni allergiche (rash, orticaria, prurito, difficolta di respiro, senso di oppressione al petto, gonfiore della bocca, viso, labbra o lingua; raucedine inusuale), bruciore, intorpidimento o formicolio, dolore toracico, confusione, diminuzione della minzione, febbre. brividi, persistente mal di gola, problemi di memoria, mentale o cambiamenti dell’umore (ad esempio, depressione), dolore muscolare, dolorabilita o debolezza (con o senza febbre o affaticamento), rossa, gonfia, vesciche o desquamazione della pelle, allo stomaco grave o mal di schiena (con o senza nausea o vomito), mancanza di respiro, sintomi di problemi al fegato (ad esempio, urine scure, feci pallide, nausea grave o persistente, perdita di appetito, o mal di stomaco, stanchezza, ingiallimento della pelle o degli occhi ), tremore, inusuali lividi o sanguinamento, stanchezza o debolezza insolite.

Questo non e un elenco completo degli effetti indesiderati che possono verificarsi. Se avete domande circa gli effetti collaterali, contattare il fornitore di assistenza sanitaria. Chiamate il vostro medico per un consiglio medico circa gli effetti collaterali. Per segnalare gli effetti collaterali per l’agenzia del caso, si prega di leggere la guida di Segnalazione Problemi da FDA.

Effetti collaterali nel dettaglio

Alcuni effetti collaterali di lovastatina non possono essere riportati. Consultare sempre il proprio medico o specialista sanitario per un consiglio medico. Si puo anche segnalare gli effetti collaterali a FDA.

Per il consumatore

Si applica a lovastatina: tablet, a rilascio prolungato orale in compresse per via orale

Ottenere assistenza medica di emergenza se si dispone di uno qualsiasi di questi segni di una reazione allergica durante l’assunzione di lovastatina: orticaria, difficolta respiratorie, gonfiore del viso, delle labbra, della lingua o della gola.

Smettere di prendere lovastatina e chiamare subito il medico se si dispone di uno qualsiasi di questi gravi effetti collaterali:

dolori muscolari, tenderness e debolezza;

febbre, stanchezza, e urine di colore scuro;

dolore al petto;

confusione, problemi di memoria;

gonfiore, aumento di peso, urinare meno del solito o non a tutti;

alto livello di zucchero nel sangue (aumento della sete, aumento della minzione, la fame, la bocca secca, respiro odore fruttato, sonnolenza, pelle secca, visione offuscata, perdita di peso), o

nausea, mal di stomaco superiore, prurito, perdita di appetito, urine scure, feci color argilla, ittero (ingiallimento della pelle o degli occhi).

Meno gravi effetti collaterali di lovastatina possono includere:

mal di testa;

dolore muscolare lieve;

dolore alle articolazioni;

mal di schiena;

lieve nausea;

mal di stomaco o indigestione;

stitichezza, o

problemi di sonno (insonnia).

Questa non e una lista completa degli effetti indesiderati possono verificarsi e altri. Chiamate il vostro medico per un consiglio medico circa gli effetti collaterali.

Per gli operatori sanitari

Si applica a lovastatina: tablet, a rilascio prolungato orale in compresse per via orale

Epatico

Persistenti aumenti dei test di funzionalita epatica a tre volte i valori normali sono stati riportati in piu del 2% dei pazienti trattati con lovastatina in studi clinici. Nel complesso, 1,5% dei pazienti sono stati ritirati dallo studio a causa di aumenti delle transaminasi sieriche. Mentre la maggior parte dei pazienti sono rimasti asintomatici con queste elevazioni, sono stati riportati casi di ittero colestatico ed epatite.

Test di funzionalita epatica devono essere attentamente monitorati. Lovastatina deve essere interrotto nei pazienti con persistenti aumenti significativi (tre volte il limite superiore del valore normale) dei parametri di funzionalita epatica.

Effetti collaterali epatici di lovastatina includono aumenti dei test di funzionalita epatica (al 2%). Altri epatiche effetti indesiderati rilevati con inibitori della HMG-CoA reduttasi sono epatite, compresa l’epatite cronica attiva, ittero colestatico, steatosi epatica, cirrosi, e necrosi epatica fulminante.

Gastrointestinale

Effetti indesiderati gastrointestinali sono tra i disturbi piu comuni nei pazienti trattati con lovastatina. Questi effetti tendono a essere lievi e di natura transitoria e spesso dissipare con il prosieguo della terapia.

Gastrointestinali effetti collaterali associati con la somministrazione di lovastatina hanno incluso flatulenza (al 6%), dolore addominale (al 6%), diarrea (al 6%), stipsi (al 5%), nausea (al 5%), dispepsia, e bruciore di stomaco. Altri effetti indesiderati gastrointestinali degli inibitori della HMG-CoA reduttasi hanno incluso pancreatite, anoressia e vomito.

Muscoloscheletrico

Inibitori della HMG-CoA reduttasi (statine) sono stati associati a rari casi di grave miopatia e rabdomiolisi, accompagnato da un aumento della creatin-chinasi, mioglobinuria, proteinuria e insufficienza renale. Queste condizioni sembrano essere dose correlata, di solito si verificano con dosi superiori a 30 mg al giorno. L’incidenza e la gravita della miopatia puo essere aumentato dalla somministrazione concomitante di lovastatina con farmaci che possono causare miopatia quando somministrati da soli, come il gemfibrozil ed altri fibrati, niacina, e di potenti inibitori del CYP450 3A4 (ad esempio, ciclosporina, azoli antifungini, antibiotici macrolidi, grandi quantita di succo di pompelmo). Altre variabili associate a un aumento del rischio di miopatia da statine comprendono, eta avanzata, bassa statura del corpo, il sesso femminile, renale e / o disfunzione epatica, periodi perioperatorie, ipotiroidismo, diabete mellito, e l’alcolismo.

Forme piu lievi di miotossicita (cioe, mialgia) sono comunemente riportati e si verificano in circa il 5% al ??7% dei pazienti che assumono un farmaco statina.

I pazienti devono essere istruiti a segnalare tempestivamente i sintomi di dolore muscolare, debolezza, o la tenerezza. Se tali sintomi si sviluppano, creatina chinasi deve essere misurata, e se marcatamente elevato, lovastatina deve essere interrotto. Il valore del monitoraggio di routine della creatina chinasi non e noto. In alcuni studi fino al 11% dei pazienti hanno sperimentato incrementi della creatin-chinasi, mentre sulla lovastatina. Nella maggior parte dei casi questi aumenti sono stati lievi, transitori, e non associati a sintomi clinici.

Itraconazolo usato in concomitanza con lovastatina ha portato ad un caso segnalato di grave rabdomiolisi in una donna di 63 anni. Si deve usare cautela quando HMG-CoA reduttasi e azoli antimicotici sono prescritti simultaneamente.

Effetti collaterali muscoloscheletrico di lovastatina hanno incluso aumenti della creatina chinasi, crampi muscolari, miopatia e rabdomiolisi. Altri effetti indesiderati muscoloscheletrici riportati con inibitori dell’HMG-CoA reduttasi sono inclusi artralgia, mialgia, rottura del tendine, e la dermatomiosite.

Inoltre, alcuni dati hanno suggerito che l’esposizione a inibitori della HMG-CoA reduttasi e associata ad un ridotto rischio di fratture ossee nelle persone di eta superiore ai 50 anni di eta.

Ematologica

Effetti collaterali ematologici tra cui anemia emolitica, trombocitopenia, porpora trombotica trombocitopenica (TTP), e leucopenia sono verificati con alcuni inibitori della HMG-CoA reduttasi. Questi effetti possono essere manifestazioni di una reazione di ipersensibilita.

Sistema nervoso

Nervoso effetti collaterali del sistema di lovastatina hanno incluso cefalea (9%) e vertigini (2%). Inoltre, uno studio ha dimostrato un aumento della latenza del sonno e il tempo totale di veglia nei pazienti trattati con lovastatina, rispetto ai pazienti trattati con pravastatina. Altri effetti indesiderati del sistema nervoso rilevati con inibitori della HMG-CoA reduttasi hanno incluso la disfunzione dei nervi cranici, tremori, vertigini, perdita di memoria, sonnolenza, perdita di peso, riduzione della funzione cognitiva, parestesia, neuropatia periferica, e la paralisi dei nervi periferici.

Renale

Effetti collaterali renali di lovastatina hanno incluso insufficienza renale acuta secondaria a rabdomiolisi.

Dermatologica

Dermatologici effetti collaterali associati con la somministrazione di lovastatina hanno incluso rash e prurito. Altri effetti indesiderati dermatologici rilevati con inibitori della HMG-CoA reduttasi hanno incluso eritema multiforme, sindrome di Stevens-Johnson, necrolisi epidermica tossica, fotosensibilita, porpora, e alopecia. Questi effetti possono essere manifestazioni di una reazione di ipersensibilita.

Endocrino

Effetti collaterali endocrini di lovastatina hanno incluso ipospermia. Altri effetti collaterali endocrini degli inibitori della HMG-CoA reduttasi hanno incluso ginecomastia e disfunzione della tiroide. Inoltre, la carenza di acido maltasi (la malattia genetica indicato anche come malattia di Pompe) e stato rivelato dopo terapia HMG-CoA in almeno un paziente presintomatico.

Ipersensibilita

Le reazioni di ipersensibilita sono segnalate raramente con gli inibitori della HMG-CoA reduttasi e hanno incluso anafilassi, angioedema, lupus eritematoso-simile sindrome, polimialgia reumatica, dermatomiosite, vasculite, porpora, trombocitopenia, leucopenia, anemia emolitica, ANA positivo, aumento VES, eosinofilia, artrite, artralgia, orticaria, astenia, fotosensibilita, febbre (anche grave ipertermia), brividi, vampate di calore, malessere, dispnea, e la necrolisi epidermica tossica.

Immunologici

Effetti collaterali immunologici di lovastatina hanno incluso una sindrome lupus-simile con ANA positivi e VES elevata. Altri effetti collaterali immunologici degli inibitori della HMG-CoA reduttasi hanno incluso polimialgia reumatica e vasculite.

Oculare

Effetti collaterali oculari degli inibitori della HMG-CoA reduttasi hanno incluso progressione della cataratta e oftalmoplegia. Non ci sono prove per sostenere gli effetti negativi della lovastatina sulla lente umana.

Metabolica

Effetti collaterali metabolici di lovastatina hanno incluso un caso di iperkaliemia in un paziente con insufficienza renale da lieve a lisinopril concomitante. Un rechallenge positivo lovastatina implicato come fattore di confusione in questo caso.

Psichiatrica

Effetti collaterali psichiatrici degli inibitori della HMG-CoA reduttasi hanno incluso riduzione della libido, ansia, insonnia, depressione, pensieri suicidi, manie, paranoia, agitazione, e incubi. Effetti collaterali psichiatrici segnalati postmarketing hanno incluso deterioramento cognitivo (ad esempio, perdita di memoria, la dimenticanza, amnesia, disturbi della memoria, confusione) associato all’uso di statine. Questi problemi cognitivi sono stati segnalati per tutte le statine. Le relazioni sono in genere non gravi, e reversibile con l’interruzione delle statine, con tempi variabili a comparsa dei sintomi (1 giorno per anni) e la risoluzione dei sintomi (mediana di 3 settimane).

Genito-urinario

Halkin, et al riportano un caso in cui l’uso sia di lovastatina e pravastatina in diverse occasioni nello stesso paziente ha portato alla impotenza reversibile. L’impotenza risolta entro 2 settimane dopo la sospensione del inibitore della HMG-CoA reduttasi.

Genitourinarie effetti collaterali associati con la somministrazione di inibitori della HMG-CoA reduttasi hanno incluso la disfunzione erettile, impotenza, e dolore ai testicoli.

Oncologica

Effetti collaterali oncologici sono stati associati con molti farmaci ipolipemizzanti, tra cui la crescita del tumore nei roditori. Lovastatina e stata specificamente associata a carcinomi epatocellulari e adenomi e adenomi polmonari. Sono necessari studi clinici a lungo termine per definire il rischio di cancro negli esseri umani.

Altro

Altri effetti indesiderati riportati postmarketing hanno incluso dolore addominale, dolore addominale, dispepsia, nausea, astenia, stanchezza, malessere, epatite, ittero, insufficienza epatica fatale e non fatale, vertigini, ipoestesia, insonnia, depressione, malattia polmonare interstiziale, disfunzione erettile e spasmi muscolari .

In caso di sovradosaggio e sospettato:

Contattare il 118 immediatamente.

La corretta conservazione di lovastatina:

Lovastatina Conservare a temperatura ambiente, tra i 68 ei 77 gradi F (20 e 25 gradi C). Conservare lontano da fonti di calore, umidita e luce. Non conservare a temperatura nella stanza da bagno. Tenere lovastatina fuori dalla portata dei bambini e lontano da animali domestici.

Informazioni generali:

Se avete domande su lovastatina, si prega di parlare con il medico, il farmacista, o il fornitore di assistenza sanitaria.

Lovastatina deve essere utilizzato solo da parte del paziente per i quali e prescritto. Non condividere con altre persone.

Se i sintomi non migliorano o se peggiorano, consultare il medico.

Verificate con il vostro farmacista su come eliminare i medicinali inutilizzati.

Tali informazioni non devono essere utilizzate per decidere se adottare o meno lovastatina o qualsiasi altro medicinale. Solo il medico ha la conoscenza e la formazione di decidere quali farmaci e giusto per te. Queste informazioni non sostiene alcuna medicina come sicuro, efficace, o approvato per il trattamento di ogni paziente o condizione di salute. Questo e solo un breve riassunto di informazioni di carattere generale su lovastatina. Esso non include tutte le informazioni sui possibili usi, indicazioni, avvertenze, precauzioni, interazioni, effetti collaterali o rischi che si possono applicare a lovastatina. Queste informazioni non sono un consulto medico specifico e non sostituisce le informazioni che ricevete dal vostro fornitore di cure mediche. E necessario parlare con il vostro fornitore di assistenza sanitaria per informazioni complete sui rischi e benefici dell’uso di lovastatina.

Related posts:

Lovastatina (Mevacor, Lovinacor, Rextat, Tavacor): effetti collaterali, controindicazioni, posologia, dosaggio, indicazioni, dosi ed interazioni

Nome Generico . lovastatina Marchi . Mevacor, Lovinacor, Rextat, Tavacor Disponibilita . solo su prescrizione Categoria di Gravidanza: X . da non usare in gravidanza

Lovastatina e usato per:

Riduce il colesterolo in alcuni pazienti. Viene usato in concomitanza con una dieta appropriata. Viene usato in alcuni pazienti per ridurre il rischio di attacco di cuore e il dolore al petto causato dall ‘angina. Viene anche utilizzato per rallentare il blocco dei vasi sanguigni e riduce la necessita di interventi per aprire i vasi occlusi. Esso puo essere utilizzato anche per altre circostanze come determinato dal medico.

Lovastatina e un inibitore della HMG-CoA reduttasi, anche noti come “statine”. Agisce riducendo la produzione di alcune sostanze grasse da parte del corpo, compreso il colesterolo.

NON utilizzare lovastatina se:

e allergico a qualsiasi ingrediente di lovastatina

ha problemi al fegato o inspiegabilmente anormali risultati delle prove di funzionalita epatica

e incinta, puo rimanere incinta, o sta allattando al seno

sta assumendo alcuni antimicotici azolici (ad esempio, itraconazolo, ketoconazolo, posaconazolo), ciclosporina, gemfibrozil, antibiotici macrolidi (ad esempio alcune, claritromicina, eritromicina), mibefradil, mifepristone, nefazodone, inibitori della proteasi (ad esempio, boceprevir, ritonavir), o telitromicina

sta assumendo conivaptan o lo hanno preso negli ultimi 7 giorni

Rivolgersi al proprio medico o il fornitore di cure mediche subito se uno di questi si applicano a voi.

Prima di usare lovastatina:

Alcune condizioni mediche possono interagire con lovastatina. Informi il medico o il farmacista se avete qualunque condizioni mediche, soprattutto se una delle seguenti si applicano a voi:

se e incinta, sta pianificando una gravidanza o l’allattamento al seno

se si e in grado di rimanere incinta

se sta assumendo qualsiasi prescrizione o medicine senza ricetta medica, la preparazione a base di erbe, o del supplemento dietetico

Se avete allergie alle medicine, alimenti, o altre sostanze

se si ha la pressione bassa, problemi renali, il diabete, la funzione della tiroide bassa, problemi muscolari (ad esempio, dolore, debolezza), disturbi del metabolismo, problemi ormonali, o problemi di elettroliti

se si beve alcool o hanno una storia di convulsioni, problemi al fegato, o abuso di alcool

se si dispone di un certo tipo di colesterolo alto (ipercolesterolemia familiare omozigote)

se sono previsti per interventi di chirurgia maggiore, di recente intervento chirurgico maggiore o una lesione grave, o avere una grave infezione

se ha avuto un trapianto d’organo e sta assumendo un medicinale che sopprime una reazione di rigetto

Alcuni medicinali possono interagire con lovastatina. Dire al vostro fornitore di cure mediche se sta assumendo altri farmaci, in particolare uno dei seguenti:

Amiodarone, la colchicina, conivaptan, ciclosporina, danazolo, daptomicina, delavirdina, diltiazem, dronedarone, fibrati (es. gemfibrozil, fenofibrato), fluconazolo, voriconazolo, o altri antimicotici azolici (ad esempio, itraconazolo, ketoconazolo, posaconazolo), acido fusidico, imatinib; antibiotici macrolidi (ad esempio, claritromicina, eritromicina), mibefradil, mifepristone, nefazodone, niacina, gli inibitori della proteasi (ad esempio, boceprevir, ritonavir), ranolazina, streptogramine (ad esempio, dalfopristin), telitromicina, ticagrelor, o verapamil perche possono aumentare il rischio di lovastatina gli effetti collaterali, tra cui gravi problemi muscolari

Il bosentan, carbamazepina, erba di efavirenz, rifamicine (ad esempio, rifampicina), o di San Giovanni, perche puo diminuire l’efficacia di lovastatina

Anticoagulanti (ad esempio, warfarin), cimetidina, sirolimus, spironolattone, o tacrolimus perche il rischio dei loro effetti collaterali possono essere aumentate di lovastatina

Questo non puo essere un elenco completo di tutte le interazioni che possono verificarsi. Chiedete al vostro fornitore di assistenza sanitaria se lovastatina puo interagire con i farmaci che si stanno assumendo. Controllare con il vostro fornitore di assistenza sanitaria prima di iniziare, interrompere o modificare il dosaggio di qualsiasi medicinale.

Lovastatina Avvertenze Gravidanza

Lovastatina e stato assegnato alla gravidanza categoria X da parte della FDA. Gli studi sugli animali hanno rivelato evidenza di teratogenicita, tra cui un aumento dell’incidenza di malformazioni scheletriche. Non esistono dati controllati in donne in gravidanza. Tuttavia, gli inibitori della HMG-CoA reduttasi sono noti per inibire i processi biosintetici necessari nello sviluppo fetale. L’associazione VATER e stato riportato in un bambino esposto a lovastatina e dextroamphetamine durante l’organogenesi. Uso Lovastatina e considerato controindicato durante la gravidanza.

L’associazione VATER (anomalie vertebrali, atresia anale, fistola tracheo-esofagea con atresia esofagea, displasia renale e radiale) e stata riportata in una ragazza la cui madre ha ricevuto lovastatina 10 mg al giorno e dextroamphetamine 10 mg al giorno durante il primo trimestre di gravidanza per il trattamento di ipercolesterolemia e aumento di peso progressivo. Entrambi i farmaci sono stati sospesi cinque settimane dopo, a circa nove settimane di gestazione, quando la gravidanza e stata confermata.

Lovastatina Avvertenze allattamento

Non vi sono dati sull’escrezione di lovastatina nel latte umano. Il fabbricante ritiene lovastatina essere controindicato durante l’allattamento.

Come usare lovastatina:

Utilizzare lovastatina come indicato dal vostro medico. Controllare l’etichetta sul medicinale per esatte istruzioni per il dosaggio.

Prendere lovastatina per via orale con il cibo.

Mangiare pompelmo o bere succo di pompelmo puo aumentare la quantita di lovastatina nel sangue, che puo aumentare il rischio di gravi effetti collaterali. Il rischio puo essere maggiore con grandi quantita di pompelmo o succo di pompelmo. Evitare grandi quantita di succo di pompelmo o di pompelmo (ad esempio, piu di uno quarto di gallone britannico al giorno). Parlate con il vostro medico o il farmacista se avete domande su di includere pompelmo o succo di pompelmo nella vostra dieta mentre sta prendendo lovastatina.

Continuare a prendere lovastatina, anche se si sente bene. Da non perdere le dosi prescritte.

Se si dimentica una dose di lovastatina, prenda il piu presto possibile. Se e quasi ora per la dose successiva, salti la dose e tornare al normale orario di dosaggio. Non prendete 2 dosi in una volta.

Chiedete al vostro fornitore di cure mediche tutte le domande che potresti avere su come utilizzare lovastatina.

Importanti informazioni di sicurezza:

Lovastatina puo provocare capogiri o visione offuscata. Questi effetti possono essere peggiore se si prendono con l’alcol o di alcuni farmaci. Utilizzare con cautela lovastatina. Non guidi o svolgere altre attivita eventualmente pericolosi finche non si sa come reagire.

Lovastatina puo causare problemi al fegato. Raramente, problemi al fegato gravi e talvolta fatali sono stati riportati in pazienti in trattamento con statine “, tra cui” medicine lovastatina. Il rischio di sviluppare problemi al fegato puo essere maggiore se si beve alcol tutti i giorni o in grandi quantita con lovastatina o se avete una storia di problemi al fegato. Verificare con il proprio medico prima di bere alcool mentre sta assumendo lovastatina. Informi il medico immediatamente se si presentano sintomi di problemi al fegato (ad esempio, urine scure, feci pallide, nausea grave o persistente, perdita di appetito, o mal di stomaco, stanchezza, ingiallimento della pelle o degli occhi).

Seguire la dieta e il programma di esercizio dato a voi dal vostro fornitore di cure mediche.

Informi il medico o il dentista che si prende lovastatina prima di sottoporsi a cure mediche o dentarie, cure d’emergenza, o interventi chirurgici.

Le donne che possono rimanere incinta devono usare metodi di contraccezione durante il trattamento con lovastatina. Verificare con il proprio medico se avete domande sull’utilizzo di controllo delle nascite.

Non prenda piu della dose raccomandata, senza essersi consultato con il medico.

Problemi muscolari (miopatia) puo verificarsi con lovastatina. Relazione di dolori muscolari, tenerezza, o debolezza per il medico, soprattutto se si hanno anche febbre o malessere generale del corpo. Informi il medico se si hanno problemi muscolari che persistono anche dopo che il medico ha detto di interrompere l’assunzione di lovastatina.

I pazienti diabetici – Lovastatina possono influenzare il livello di zucchero nel sangue. Verificare i livelli di zucchero nel sangue da vicino. Chiedete al vostro medico prima di modificare la dose di medicina per il diabete.

Le prove di laboratorio, compresi i livelli di colesterolo nel sangue, funzione epatica, e creatina fosfochinasi (CPK) nel sangue i livelli, possono essere effettuati durante l’utilizzo lovastatina. Questi test possono essere utilizzati per monitorare la sua condizione o di controllo degli effetti collaterali. Essere sicuri di mantenere tutti i medici e gli appuntamenti di laboratorio.

Utilizzare lovastatina con cautela nei pazienti anziani e possono essere piu sensibili ai suoi effetti, i problemi muscolari particolarmente gravi.

Lovastatina deve essere usato con estrema cautela nei bambini di eta inferiore ai 10 anni e in quelli che non hanno raggiunto la puberta, la sicurezza e l’efficacia di questi bambini non sono state confermate.

Gravidanza e allattamento: Non usare lovastatina in caso di gravidanza. Essa puo causare danni al feto. Evitare la gravidanza mentre si sta prendendo. Se si pensa di poter essere incinta, contattare immediatamente il medico. Non e noto se lovastatina si trova nel latte materno. Non allattare al seno durante il trattamento con lovastatina.

Possibili effetti collaterali di lovastatina:

Tutti i farmaci possono causare effetti indesiderati, ma molte persone non hanno, o hanno minori effetti collaterali. Verificare con il proprio medico se uno qualsiasi di questi effetti indesiderati comuni piu persistono o diventano fastidiosi:

Rivolgersi ad un medico immediatamente se uno qualsiasi di questi effetti indesiderati gravi si verificano:

Gravi reazioni allergiche (rash, orticaria, prurito, difficolta di respiro, senso di oppressione al petto, gonfiore della bocca, viso, labbra o lingua; raucedine inusuale), bruciore, intorpidimento o formicolio, dolore toracico, confusione, diminuzione della minzione, febbre. brividi, persistente mal di gola, problemi di memoria, mentale o cambiamenti dell’umore (ad esempio, depressione), dolore muscolare, dolorabilita o debolezza (con o senza febbre o affaticamento), rossa, gonfia, vesciche o desquamazione della pelle, allo stomaco grave o mal di schiena (con o senza nausea o vomito), mancanza di respiro, sintomi di problemi al fegato (ad esempio, urine scure, feci pallide, nausea grave o persistente, perdita di appetito, o mal di stomaco, stanchezza, ingiallimento della pelle o degli occhi ), tremore, inusuali lividi o sanguinamento, stanchezza o debolezza insolite.

Questo non e un elenco completo degli effetti indesiderati che possono verificarsi. Se avete domande circa gli effetti collaterali, contattare il fornitore di assistenza sanitaria. Chiamate il vostro medico per un consiglio medico circa gli effetti collaterali. Per segnalare gli effetti collaterali per l’agenzia del caso, si prega di leggere la guida di Segnalazione Problemi da FDA.

Effetti collaterali nel dettaglio

Alcuni effetti collaterali di lovastatina non possono essere riportati. Consultare sempre il proprio medico o specialista sanitario per un consiglio medico. Si puo anche segnalare gli effetti collaterali a FDA.

Per il consumatore

Si applica a lovastatina: tablet, a rilascio prolungato orale in compresse per via orale

Ottenere assistenza medica di emergenza se si dispone di uno qualsiasi di questi segni di una reazione allergica durante l’assunzione di lovastatina: orticaria, difficolta respiratorie, gonfiore del viso, delle labbra, della lingua o della gola.

Smettere di prendere lovastatina e chiamare subito il medico se si dispone di uno qualsiasi di questi gravi effetti collaterali:

dolori muscolari, tenderness e debolezza;

febbre, stanchezza, e urine di colore scuro;

dolore al petto;

confusione, problemi di memoria;

gonfiore, aumento di peso, urinare meno del solito o non a tutti;

alto livello di zucchero nel sangue (aumento della sete, aumento della minzione, la fame, la bocca secca, respiro odore fruttato, sonnolenza, pelle secca, visione offuscata, perdita di peso), o

nausea, mal di stomaco superiore, prurito, perdita di appetito, urine scure, feci color argilla, ittero (ingiallimento della pelle o degli occhi).

Meno gravi effetti collaterali di lovastatina possono includere:

mal di testa;

dolore muscolare lieve;

dolore alle articolazioni;

mal di schiena;

lieve nausea;

mal di stomaco o indigestione;

stitichezza, o

problemi di sonno (insonnia).

Questa non e una lista completa degli effetti indesiderati possono verificarsi e altri. Chiamate il vostro medico per un consiglio medico circa gli effetti collaterali.

Per gli operatori sanitari

Si applica a lovastatina: tablet, a rilascio prolungato orale in compresse per via orale

Epatico

Persistenti aumenti dei test di funzionalita epatica a tre volte i valori normali sono stati riportati in piu del 2% dei pazienti trattati con lovastatina in studi clinici. Nel complesso, 1,5% dei pazienti sono stati ritirati dallo studio a causa di aumenti delle transaminasi sieriche. Mentre la maggior parte dei pazienti sono rimasti asintomatici con queste elevazioni, sono stati riportati casi di ittero colestatico ed epatite.

Test di funzionalita epatica devono essere attentamente monitorati. Lovastatina deve essere interrotto nei pazienti con persistenti aumenti significativi (tre volte il limite superiore del valore normale) dei parametri di funzionalita epatica.

Effetti collaterali epatici di lovastatina includono aumenti dei test di funzionalita epatica (al 2%). Altri epatiche effetti indesiderati rilevati con inibitori della HMG-CoA reduttasi sono epatite, compresa l’epatite cronica attiva, ittero colestatico, steatosi epatica, cirrosi, e necrosi epatica fulminante.

Gastrointestinale

Effetti indesiderati gastrointestinali sono tra i disturbi piu comuni nei pazienti trattati con lovastatina. Questi effetti tendono a essere lievi e di natura transitoria e spesso dissipare con il prosieguo della terapia.

Gastrointestinali effetti collaterali associati con la somministrazione di lovastatina hanno incluso flatulenza (al 6%), dolore addominale (al 6%), diarrea (al 6%), stipsi (al 5%), nausea (al 5%), dispepsia, e bruciore di stomaco. Altri effetti indesiderati gastrointestinali degli inibitori della HMG-CoA reduttasi hanno incluso pancreatite, anoressia e vomito.

Muscoloscheletrico

Inibitori della HMG-CoA reduttasi (statine) sono stati associati a rari casi di grave miopatia e rabdomiolisi, accompagnato da un aumento della creatin-chinasi, mioglobinuria, proteinuria e insufficienza renale. Queste condizioni sembrano essere dose correlata, di solito si verificano con dosi superiori a 30 mg al giorno. L’incidenza e la gravita della miopatia puo essere aumentato dalla somministrazione concomitante di lovastatina con farmaci che possono causare miopatia quando somministrati da soli, come il gemfibrozil ed altri fibrati, niacina, e di potenti inibitori del CYP450 3A4 (ad esempio, ciclosporina, azoli antifungini, antibiotici macrolidi, grandi quantita di succo di pompelmo). Altre variabili associate a un aumento del rischio di miopatia da statine comprendono, eta avanzata, bassa statura del corpo, il sesso femminile, renale e / o disfunzione epatica, periodi perioperatorie, ipotiroidismo, diabete mellito, e l’alcolismo.

Forme piu lievi di miotossicita (cioe, mialgia) sono comunemente riportati e si verificano in circa il 5% al ??7% dei pazienti che assumono un farmaco statina.

I pazienti devono essere istruiti a segnalare tempestivamente i sintomi di dolore muscolare, debolezza, o la tenerezza. Se tali sintomi si sviluppano, creatina chinasi deve essere misurata, e se marcatamente elevato, lovastatina deve essere interrotto. Il valore del monitoraggio di routine della creatina chinasi non e noto. In alcuni studi fino al 11% dei pazienti hanno sperimentato incrementi della creatin-chinasi, mentre sulla lovastatina. Nella maggior parte dei casi questi aumenti sono stati lievi, transitori, e non associati a sintomi clinici.

Itraconazolo usato in concomitanza con lovastatina ha portato ad un caso segnalato di grave rabdomiolisi in una donna di 63 anni. Si deve usare cautela quando HMG-CoA reduttasi e azoli antimicotici sono prescritti simultaneamente.

Effetti collaterali muscoloscheletrico di lovastatina hanno incluso aumenti della creatina chinasi, crampi muscolari, miopatia e rabdomiolisi. Altri effetti indesiderati muscoloscheletrici riportati con inibitori dell’HMG-CoA reduttasi sono inclusi artralgia, mialgia, rottura del tendine, e la dermatomiosite.

Inoltre, alcuni dati hanno suggerito che l’esposizione a inibitori della HMG-CoA reduttasi e associata ad un ridotto rischio di fratture ossee nelle persone di eta superiore ai 50 anni di eta.

Ematologica

Effetti collaterali ematologici tra cui anemia emolitica, trombocitopenia, porpora trombotica trombocitopenica (TTP), e leucopenia sono verificati con alcuni inibitori della HMG-CoA reduttasi. Questi effetti possono essere manifestazioni di una reazione di ipersensibilita.

Sistema nervoso

Nervoso effetti collaterali del sistema di lovastatina hanno incluso cefalea (9%) e vertigini (2%). Inoltre, uno studio ha dimostrato un aumento della latenza del sonno e il tempo totale di veglia nei pazienti trattati con lovastatina, rispetto ai pazienti trattati con pravastatina. Altri effetti indesiderati del sistema nervoso rilevati con inibitori della HMG-CoA reduttasi hanno incluso la disfunzione dei nervi cranici, tremori, vertigini, perdita di memoria, sonnolenza, perdita di peso, riduzione della funzione cognitiva, parestesia, neuropatia periferica, e la paralisi dei nervi periferici.

Renale

Effetti collaterali renali di lovastatina hanno incluso insufficienza renale acuta secondaria a rabdomiolisi.

Dermatologica

Dermatologici effetti collaterali associati con la somministrazione di lovastatina hanno incluso rash e prurito. Altri effetti indesiderati dermatologici rilevati con inibitori della HMG-CoA reduttasi hanno incluso eritema multiforme, sindrome di Stevens-Johnson, necrolisi epidermica tossica, fotosensibilita, porpora, e alopecia. Questi effetti possono essere manifestazioni di una reazione di ipersensibilita.

Endocrino

Effetti collaterali endocrini di lovastatina hanno incluso ipospermia. Altri effetti collaterali endocrini degli inibitori della HMG-CoA reduttasi hanno incluso ginecomastia e disfunzione della tiroide. Inoltre, la carenza di acido maltasi (la malattia genetica indicato anche come malattia di Pompe) e stato rivelato dopo terapia HMG-CoA in almeno un paziente presintomatico.

Ipersensibilita

Le reazioni di ipersensibilita sono segnalate raramente con gli inibitori della HMG-CoA reduttasi e hanno incluso anafilassi, angioedema, lupus eritematoso-simile sindrome, polimialgia reumatica, dermatomiosite, vasculite, porpora, trombocitopenia, leucopenia, anemia emolitica, ANA positivo, aumento VES, eosinofilia, artrite, artralgia, orticaria, astenia, fotosensibilita, febbre (anche grave ipertermia), brividi, vampate di calore, malessere, dispnea, e la necrolisi epidermica tossica.

Immunologici

Effetti collaterali immunologici di lovastatina hanno incluso una sindrome lupus-simile con ANA positivi e VES elevata. Altri effetti collaterali immunologici degli inibitori della HMG-CoA reduttasi hanno incluso polimialgia reumatica e vasculite.

Oculare

Effetti collaterali oculari degli inibitori della HMG-CoA reduttasi hanno incluso progressione della cataratta e oftalmoplegia. Non ci sono prove per sostenere gli effetti negativi della lovastatina sulla lente umana.

Metabolica

Effetti collaterali metabolici di lovastatina hanno incluso un caso di iperkaliemia in un paziente con insufficienza renale da lieve a lisinopril concomitante. Un rechallenge positivo lovastatina implicato come fattore di confusione in questo caso.

Psichiatrica

Effetti collaterali psichiatrici degli inibitori della HMG-CoA reduttasi hanno incluso riduzione della libido, ansia, insonnia, depressione, pensieri suicidi, manie, paranoia, agitazione, e incubi. Effetti collaterali psichiatrici segnalati postmarketing hanno incluso deterioramento cognitivo (ad esempio, perdita di memoria, la dimenticanza, amnesia, disturbi della memoria, confusione) associato all’uso di statine. Questi problemi cognitivi sono stati segnalati per tutte le statine. Le relazioni sono in genere non gravi, e reversibile con l’interruzione delle statine, con tempi variabili a comparsa dei sintomi (1 giorno per anni) e la risoluzione dei sintomi (mediana di 3 settimane).

Genito-urinario

Halkin, et al riportano un caso in cui l’uso sia di lovastatina e pravastatina in diverse occasioni nello stesso paziente ha portato alla impotenza reversibile. L’impotenza risolta entro 2 settimane dopo la sospensione del inibitore della HMG-CoA reduttasi.

Genitourinarie effetti collaterali associati con la somministrazione di inibitori della HMG-CoA reduttasi hanno incluso la disfunzione erettile, impotenza, e dolore ai testicoli.

Oncologica

Effetti collaterali oncologici sono stati associati con molti farmaci ipolipemizzanti, tra cui la crescita del tumore nei roditori. Lovastatina e stata specificamente associata a carcinomi epatocellulari e adenomi e adenomi polmonari. Sono necessari studi clinici a lungo termine per definire il rischio di cancro negli esseri umani.

Altro

Altri effetti indesiderati riportati postmarketing hanno incluso dolore addominale, dolore addominale, dispepsia, nausea, astenia, stanchezza, malessere, epatite, ittero, insufficienza epatica fatale e non fatale, vertigini, ipoestesia, insonnia, depressione, malattia polmonare interstiziale, disfunzione erettile e spasmi muscolari .

In caso di sovradosaggio e sospettato:

Contattare il 118 immediatamente.

La corretta conservazione di lovastatina:

Lovastatina Conservare a temperatura ambiente, tra i 68 ei 77 gradi F (20 e 25 gradi C). Conservare lontano da fonti di calore, umidita e luce. Non conservare a temperatura nella stanza da bagno. Tenere lovastatina fuori dalla portata dei bambini e lontano da animali domestici.

Informazioni generali:

Se avete domande su lovastatina, si prega di parlare con il medico, il farmacista, o il fornitore di assistenza sanitaria.

Lovastatina deve essere utilizzato solo da parte del paziente per i quali e prescritto. Non condividere con altre persone.

Se i sintomi non migliorano o se peggiorano, consultare il medico.

Verificate con il vostro farmacista su come eliminare i medicinali inutilizzati.

Tali informazioni non devono essere utilizzate per decidere se adottare o meno lovastatina o qualsiasi altro medicinale. Solo il medico ha la conoscenza e la formazione di decidere quali farmaci e giusto per te. Queste informazioni non sostiene alcuna medicina come sicuro, efficace, o approvato per il trattamento di ogni paziente o condizione di salute. Questo e solo un breve riassunto di informazioni di carattere generale su lovastatina. Esso non include tutte le informazioni sui possibili usi, indicazioni, avvertenze, precauzioni, interazioni, effetti collaterali o rischi che si possono applicare a lovastatina. Queste informazioni non sono un consulto medico specifico e non sostituisce le informazioni che ricevete dal vostro fornitore di cure mediche. E necessario parlare con il vostro fornitore di assistenza sanitaria per informazioni complete sui rischi e benefici dell’uso di lovastatina.

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Regular Bleach, Clorilex

Clorox® Regular-Bleach 1

Dirt Stains

To Remove Stains and Clean: If bleach dispenser is available, fill to the maximum level. Add laundry. If you don't have a dispenser, for best results add ? cup Clorox® Regular-Bleach 5 minutes after the wash cycle has begun. To Sanitize: Add ? cup of Clorox® Regular-Bleach to a standard-size washer following the laundry use directions.

*Always read and follow precautions and usage directions before using cleaning products. Store out of reach of children.

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*Always read and follow precautions and usage directions before using cleaning products. Store out of reach of children.

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*Always read and follow precautions and usage directions before using cleaning products. Store out of reach of children.

Can I safely use Clorox® Regular-Bleach around children, pets and pregnant women?

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Rated 5 out of 5 by KKISHA CLOROX YES I LOVE USING CLOROX IT MAKES THINGS SMELL CLEAN AND FRESH IT ALSO GETS MY WHITES WHITE AND I LOVE CLEANING MY BATHROOMS WITH IT. ITS A GREAT PRODUCT TO USE AND I WILL RECOMEND IT ANYTIME. August 8, 2016

2016-09-18 T09:05:28.030-05:00

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Cataflam Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Catafast

Cataflam

GENERIC NAME(S): DICLOFENAC POTASSIUM

Warnings

Nonsteroidal anti-inflammatory drugs (including diclofenac ) may rarely increase the risk for a heart attack or stroke. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking. family history of heart disease. or conditions such as high blood pressure or diabetes ), or with longer use. This drug should not be taken right before or after heart bypass surgery (CABG).

Also, this drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning symptoms at any time while taking this drug. Older adults may be at higher risk for this effect. (See also Precautions and Drug Interactions sections.)

Stop taking diclofenac and get medical help right away if you notice any of the following rare but serious side effects: bloody or black/tarry stools, persistent stomach /abdominal pain. vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating. weakness on one side of the body, sudden vision changes, slurred speech.

Talk with your doctor or pharmacist about the risks and benefits of treatment with this medication .

Uses

Diclofenac is used to relieve pain and swelling (inflammation ) from various mild to moderate painful conditions. It is used to treat muscle aches, backaches, dental pain, menstrual cramps. and sports injuries. It also reduces pain, swelling, and joint stiffness caused by arthritis. Reducing these symptoms helps you do more of your normal daily activities. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID).

If you are treating a chronic condition such as arthritis. ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat gout attacks.

How to use Cataflam

Read the Medication Guide provided by your pharmacist before you start using diclofenac and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with a full glass of water (8 ounces /240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this drug. To prevent stomach upset, take this medication with food, milk, or an antacid.

There are different brands and forms of this medication available. Because different brands deliver different amounts of medication, do not switch brands of diclofenac without your doctor's permission and directions.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To minimize side effect risks (such as stomach bleeding), use this medication at the lowest effective dose for the shortest possible length of time. Do not increase your dose or take it more often than prescribed. For chronic conditions such as arthritis, continue taking it as directed by your doctor. Discuss the risks and benefits with your doctor or pharmacist.

For certain conditions (such as arthritis), it may take up to 2 weeks of regular use before the full benefits of this drug take effect.

If you are taking this drug on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Tell your doctor if your condition worsens.

Side Effects

See also Warning section.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if any of these unlikely but serious side effects occur: swelling of the hands or feet (edema ), sudden or unexplained weight gain. hearing changes (such as ringing in the ears ), mental/mood changes, difficult/painful swallowing, unusual tiredness.

Get medical help right away if any of these rare but very serious side effects occur: signs of kidney problems (such as change in the amount of urine), unexplained stiff neck .

This drug may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, including: dark urine, persistent nausea/vomiting/loss of appetite, stomach/abdominal pain, yellowing eyes or skin .

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

See also Warning section.

Before taking diclofenac, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), bleeding or clotting problems, growths in the nose (nasal polyps), heart disease (such as previous heart attack), high blood pressure, liver disease, stomach/intestinal/esophagus problems (such as bleeding, ulcers, recurring heartburn), stroke.

Kidney problems can sometimes occur with the use of NSAID medications, including diclofenac. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have any unusual change in the amount of urine.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths or sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Older adults may be more sensitive to the side effects of this drug, especially stomach/intestinal bleeding, kidney problems, and worsening heart problems.

Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

This drug passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, lithium, methotrexate, "water pills" (diuretics such as furosemide), corticosteroids (such as prednisone).

This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as celecoxib, ibuprofen, or ketorolac). These drugs are similar to diclofenac and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe stomach pain, vomit that looks like coffee grounds, extreme drowsiness, slow/shallow breathing, seizures.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as blood pressure, complete blood count, liver and kidney function tests) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Non-drug treatment that is approved by your doctor for arthritis (such as weight loss if needed, strengthening and conditioning exercises) may help improve your flexibility, range of motion, and joint function. Consult your doctor for specific instructions.

Missed Dose

If you are prescribed this drug on a regular schedule (not just "as needed") and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

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Medamet Rezeptfrei Kaufen ? Qualitat; ? Mit Niedrigen Preisen; ? Lieferung, Medamet

Flagyl ER wird zur Behandlung von bestimmten bakteriellen Infektionen der Vagina (bakterielle Vaginose) verwendet. Flagyl ER ist ein orales antiprotozoal und antibakteriell. Es wird angenommen, dass durch die Eingabe der Bakterienzelle, die auf einige Komponenten der Zelle, und zerstoren die Bakterien arbeiten.

Verwenden Sie Flagyl ER wie von Ihrem Arzt verordnet wurde.

Nehmen Sie Flagyl ER durch den Mund auf leeren Magen mindestens 1 Stunde vor oder 2 Stunden nach dem Essen.

Schlucken Flagyl ER Ganzes. Nicht brechen, zerdrucken, kauen oder vor dem Schlucken.

Zur Klarung Ihrer Infektion vollstandig nehmen Flagyl ER fur das gesamte Verlauf der Behandlung. Halten Sie dabei, selbst wenn Sie sich besser in ein paar Tagen zu spuren.

Wenn Sie eine Dosis von Flagyl ER, bringen Sie es so bald wie moglich. Wenn es fast Zeit fur Ihre nachste Dosis ist, uberspringen Sie die vergessene Dosis und gehen Sie zuruck zu Ihrem regelma?igen Dosierungsschema. Nehmen Sie nicht 2 Dosen auf einmal.

Fragen Sie Ihren Arzt Fragen konnen Sie sich daruber, wie Sie Flagyl ER verwenden haben kann.

Shop Flagyl ER bei 77 Grad F (25 Grad C). Kurze Lagerung bei Temperaturen zwischen 59 und 86 Grad F (15 und 30 Grad C) ist nicht gestattet. Lager weg von der Hitze, Feuchtigkeit und Licht. Nicht im Bad. Halten Sie Flagyl ER aus der Reichweite von Kindern und weg von Haustieren.

Verwenden Sie KEINE Flagyl ER wenn:

Sie sind allergisch gegen jegliche Zutaten in Flagyl ER oder zu einem anderen nitroimidazole (zB Tinidazol)

Sie sind in der ersten trimestr der Schwangerschaft

Sie nehmen Busulfan, ein Mutterkornalkaloid (zB Ergotamin), oder Sie haben Disulfiram innerhalb der letzten 2 Wochen eingenommen

Sie nehmen ein HIV-Protease-Inhibitor, der Alkohol enthalt (z. B. Amprenavir Losung); uberprufen Sie mit Ihrem Apotheker, wenn Sie unsicher sind, ob das Arzneimittel enthalt Alkohol

Sie Alkohol trinken.

Fragen Sie Ihren Arzt oder Ihre Arztin sofort, wenn einer dieser Punkte auf Sie zutreffen.

Einige medizinische Bedingungen konnen mit Flagyl ER interagieren. Informieren Sie Ihren Arzt oder Apotheker, wenn Sie irgendwelche medizinischen Bedingungen haben, vor allem, wenn einer der folgenden Punkte auf Sie zutrifft:

wenn Sie schwanger sind, planen, schwanger zu werden, oder stillen

wenn Sie verschreibungspflichtige oder nicht verschreibungspflichtige Arzneimittel, pflanzliche Zubereitung oder Nahrungserganzungsmittel

wenn Sie Allergien gegen Medikamente, Nahrungsmittel oder andere Substanzen,

wenn Sie Nerven, Gehirn, Blut oder Probleme, Morbus Crohn, oder eine Geschichte von Leberproblemen oder Anfalle.

Einige Arzneimittel konnen mit Flagyl ER interagieren. Informieren Sie Ihren Arzt, wenn Sie andere Arzneimittel einnehmen, vor allem einer der folgenden Eigenschaften sind:

Disulfiram, da Nebenwirkungen wie psychische oder Stimmungsschwankungen auftreten konnen

Amiodaron, weil das Risiko von Herzrhythmusstorungen erhoht werden kann

Barbiturate (zB Phenobarbital) oder Phenytoin, weil sie verringern kann Flagyl ER die Wirksamkeit

Antikoagulantien (zB Warfarin), Busulfan, Cyclosporin, Mutterkorn-Alkaloide (zB Ergotamin), HIV-Protease-Inhibitoren die Alkohol enthalten (z. B. Amprenavir Losung), Lithium oder Makrolid-Immunsuppressiva (zB Tacrolimus), weil das Risiko der Nebenwirkungen konnen stieg um Flagyl ER.

Dies kann nicht eine vollstandige Liste aller Interaktionen, die auftreten konnen. Fragen Sie Ihren Arzt, wenn Flagyl ER mit anderen Medikamenten, die Sie einnehmen. Prufen Sie mit Ihrem Arzt, bevor Sie starten, stoppen, oder andern Sie die Dosis einer Medizin.

Wichtige Sicherheitshinweise:

Flagyl ER kann Schwindel verursachen. Dieser Effekt kann noch schlimmer, wenn Sie es mit Alkohol oder bestimmte Medikamente. Verwenden Sie Flagyl ER mit Vorsicht. Nicht Auto fahren oder andere, moglicherweise unsichere Aufgaben, bis Sie, wie Sie darauf reagieren.

Trinken Sie keinen Alkohol wahrend der Einnahme von Flagyl ER und fur mindestens 3 Tage nach der letzten Dosis.

Fragen Sie Ihren Arzt sofort, wenn Bauchschmerzen oder Krampfe, schwerer Durchfall oder Blut im Stuhl auftreten. Behandeln Sie Durchfall nicht, ohne vorher Rucksprache mit Ihrem Arzt.

Flagyl ER funktioniert nur gegen Bakterien, es nicht zu behandeln virale Infektionen (zB eine Erkaltung).

Achten Sie darauf, Flagyl ER fur das gesamte Verlauf der Behandlung zu verwenden. Wenn Sie das nicht tun, kann die Medizin nicht klar, bis Ihre Infektion vollstandig. Die Bakterien konnten auch weniger anfallig fur diese oder andere Arzneimittel. Dies konnte die Infektion schwerer zu behandeln in der Zukunft.

Langfristige oder wiederholte Verwendung von Flagyl ER kann eine zweite Infektion. Informieren Sie Ihren Arzt, wenn Sie Anzeichen einer zweiten Infektion auftreten. Ihr Arzneimittel mussen geandert werden, um diese zu behandeln.

Flagyl ER kann mit bestimmten Labortests. Achten Sie darauf, Ihren Arzt und Labor-Mitarbeiter wissen, dass Sie nehmen Flagyl ER.

Labortests, einschlie?lich der Leberfunktion und wei?en Blutkorperchen, kann durchgefuhrt werden, wahrend Sie Flagyl ER verwenden. Diese Tests konnen verwendet werden, um Ihren Zustand zu uberprufen oder auf Nebenwirkungen zu uberwachen. Achten Sie darauf, alle Arzt-und Labor-Terminen.

Verwenden Sie Flagyl ER mit Vorsicht bei alteren Menschen, sie kann mehr empfindlich auf ihre Auswirkungen.

Flagyl ER sollte mit au?erster Vorsicht bei Kindern angewendet werden, Sicherheit und Wirksamkeit bei Kindern wurden nicht bestatigt.

Schwangerschaft und Stillzeit: Wenn Sie schwanger werden, wenden Sie sich an Ihren Arzt. Sie mussen die Vorteile und Risiken der Verwendung von Flagyl ER zu diskutieren, wahrend Sie schwanger sind. Verwenden Sie keine Flagyl ER in den ersten 3 Monaten der Schwangerschaft. Flagyl ER ist in der Muttermilch gefunden. Nicht stillen wahrend der Einnahme von Flagyl ER.

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Macs / Teniss – ATP – Challenger – Kenitra

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Macs / Teniss – ATP – ITF Dubultspeles – Egipte

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Macs / Teniss – WTA – ITF Dubultspeles – Brno

Sold Out, Biolan

Introducing the Envirolet® Greywater BIOLAN 125 . This system compliments your Envirolet® Composting Toilet System as solution to handle your sink, shower, dishwasher, etc. water.

Features • Handles greywater (sink, shower, etc.) filter • 125 Gallons (500L) a day capacity • Installs above ground • Ecological filter material • Insulated, so can be used in winter

How it works The operation of the Envirolet® Greywater BIOLAN 125 works on the innovative mechanical and biological filtration of wastewater. Organic filter material in the filter catches the particulate in the wastewater. The micro-organisms living on the surface of the filter material use the impurities as their nutrition.

The Envirolet® Greywater BIOLAN 125 consists of ten filter boxes placed one on top of the other. The wastewater enters through the uppermost filter box. Inside the filter, the wastewater flows by gravity from one filter layer to the other through the openings in the end of the box. The circulation of air inside the unit is natural: air flows in through the lower air valve in the rear wall and out through the upper valve. The oxygen supply to the micro-organisms is essential for the operation of the unit.

Specifications Weight: 165 lbs. (75kg) Dimensions (H x W x D): 48" x 24" x 39.5" (123cm x 60cm x 100cm) Pipe Connection: for ? 75 mm sewer pipes Height difference of inlet and outlet connectors: 104cm (height of fall) Capacity: 125 Gallons (500L) a day

Includes Greywater Filter Material for one years use.

Phenazopyridine Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Phenazopyridin

phenazopyridine

GENERIC NAME(S): PHENAZOPYRIDINE HCL

Uses

This medication is used to relieve symptoms caused by irritation of the urinary tract such as pain, burning, and the feeling of needing to urinate urgently or frequently. This drug does not treat the cause of the urinary irritation, but it can help relieve the symptoms while other treatments take effect. Phenazopyridine is a dye that works as a painkiller to soothe the lining of the urinary tract.

How to use phenazopyridine

Take this medication by mouth. usually 3 times daily after meals or as directed by your doctor. If you are taking this medication along with antibiotics for symptoms related to a urinary tract infection. or are self-treating, do not take it for more than 2 days without talking to your doctor.

Dosage is based on your medical condition and response to therapy.

Inform your doctor if your condition persists or worsens.

Side Effects

Headache. dizziness. or stomach upset may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these rare but very serious side effects occur: yellowing skin /eyes. dark urine, signs of kidney problems (such as change in the amount of urine, bloody urine), stomach /abdominal pain. vomiting. fever, chills, easy bruising/bleeding, unusual tiredness, shortness of breath, fast heartbeat, seizures .

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking phenazopyridine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: kidney disease. liver disease, blood disorders (e. g. G6PD deficiency. hemolytic anemia ).

Before using this medication, tell your doctor or pharmacist your medical history.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Phenazopyridine can dye your urine and tears orange-red. This may stain clothing and contact lenses. Do not wear contact lenses while using this medication. Urine and tears will return to normal color after the medication is stopped.

Tell your doctor if you are pregnant before using this medication.

It is not known whether this drug passes into breast milk. Consult your doctor before breast - feeding.

Interactions

Your healthcare professionals (e. g. doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

Phenazopyridine can interfere with certain laboratory tests (including urine tests for kidney function, bilirubin. and sugar levels ), possibly causing false test results. Home urine tests (including diabetic tests) may be affected. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include unusual tiredness, skin color changes, change in the amount of urine, shortness of breath, fast heartbeat, yellowing skin/eyes. easy bleeding/bruising, or seizures.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not take it later for another pain-related condition of the urinary tract unless told to do so by your doctor. A different medication may be necessary in those cases.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised April 2016. Copyright(c) 2016 First Databank, Inc.

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Lamisil - Anti Fungal, Skinabin

Product Description Common use Lamisil is an anti-fungal antibiotic used to treat tinea versicolor, a fungal infection that produces brown, tan, white spots on the trunk of the body or other fungal infections such as athlete's foot, jock itch, and ringworm. Lamisil works by killing sensitive fungi by interfering with the formation of the fungal cell membrane.

Dosage and direction Take it orally with full glass of water. Swallow it without chewing. Usually it taken for 6 to 12 weeks. The recommended dose is different from type of infection: 1. For onychomycosis: Adults and teenagers 250 mg once a day for 6 to 12 weeks. Lamisil is used in children just after doctor's permission. 2. For tinea corporis: Adults and teenagers 250 mg once a day for 2 to 4 weeks. Lamisil is used in children just after doctor's permission. 3. For tinea cruris (ringworm of the groin; jock itch): Adults and teenagers 250 mg once a day for 2 to 4 weeks. Lamisil is used in children just after doctor's permission. 4. For tinea pedis: Adults and teenagers 250 mg once a day for 2 to 6 weeks. Lamisil is used in children just after doctor's permission. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using.

Precautions Before using this medicine, consult your doctor or pharmacist if you have a certain blood disorder or severe liver disease. Don't forget to tell your medical history, especially if it includes lupus. Driving is not recommended while you are taking this medication because it may cause dizziness or less alertness. Drinking alcohol during treatment may cause a fast heartbeat and flushing of the skin. Avoid sun, tanning booths, and sunlamps and use a sunscreen and wear protective clothing when going outdoors. Lamisil should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use before breast-feeding without doctor's advice.

Contraindications Lamisil is not allowed to people who have problems with their liver or kidneys, hypersensitive to any component of this dug.

Possible side effect They may include an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: joint pain or swelling, swollen glands, patchy skin color, or a butterfly-shaped skin rash over your cheeks and nose fever, chills, body aches, flu symptoms; changes in your vision; weight loss due to taste changes; scaly, itchy, and flaky skin rash; fever, sore throat, and headache with a severe blistering, peeling, and red skin rash. Less serious include: stomach pain, heartburn, diarrhea; headache; tired feeling; runny or stuffy nose, sore throat, cold symptoms; mild skin rash or itching; unusual or unpleasant taste in your mouth; or decreased taste sensation. If you experience one of them stop using Lamisil and tell your doctor as soon as possible. Also consult your doctor about any side effect that seems unusual.

Drug interaction Lamisil interacts with the following medications: Cyclosporine Metoprolol Nortriptyline Warfarin Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the effect of drugs, so consult your doctor about its interactions.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usual dose next day at the same time regularly.

Overdose Symptoms of Lamisil overdose may include: dizziness, stomach pain, nausea, vomiting, skin rash, or urinating more than usual. If you experience one of them call your doctor immediately.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration date.

Disclaimer We provide only general information about medications that does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Product Description Common use Lamisil is an anti-fungal antibiotic used to treat tinea versicolor, a fungal infection that produces brown, tan, white spots on the trunk of the body or other fungal infections such as athlete's foot, jock itch, and ringworm. Lamisil works by killing sensitive fungi by interfering with the formation of the fungal cell membrane.

Dosage and direction Take it orally with full glass of water. Swallow it without chewing. Usually it taken for 6 to 12 weeks. The recommended dose is different from type of infection: 1. For onychomycosis: Adults and teenagers 250 mg once a day for 6 to 12 weeks. Lamisil is used in children just after doctor's permission. 2. For tinea corporis: Adults and teenagers 250 mg once a day for 2 to 4 weeks. Lamisil is used in children just after doctor's permission. 3. For tinea cruris (ringworm of the groin; jock itch): Adults and teenagers 250 mg once a day for 2 to 4 weeks. Lamisil is used in children just after doctor's permission. 4. For tinea pedis: Adults and teenagers 250 mg once a day for 2 to 6 weeks. Lamisil is used in children just after doctor's permission. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using.

Precautions Before using this medicine, consult your doctor or pharmacist if you have a certain blood disorder or severe liver disease. Don't forget to tell your medical history, especially if it includes lupus. Driving is not recommended while you are taking this medication because it may cause dizziness or less alertness. Drinking alcohol during treatment may cause a fast heartbeat and flushing of the skin. Avoid sun, tanning booths, and sunlamps and use a sunscreen and wear protective clothing when going outdoors. Lamisil should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use before breast-feeding without doctor's advice.

Contraindications Lamisil is not allowed to people who have problems with their liver or kidneys, hypersensitive to any component of this dug.

Possible side effect They may include an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: joint pain or swelling, swollen glands, patchy skin color, or a butterfly-shaped skin rash over your cheeks and nose fever, chills, body aches, flu symptoms; changes in your vision; weight loss due to taste changes; scaly, itchy, and flaky skin rash; fever, sore throat, and headache with a severe blistering, peeling, and red skin rash. Less serious include: stomach pain, heartburn, diarrhea; headache; tired feeling; runny or stuffy nose, sore throat, cold symptoms; mild skin rash or itching; unusual or unpleasant taste in your mouth; or decreased taste sensation. If you experience one of them stop using Lamisil and tell your doctor as soon as possible. Also consult your doctor about any side effect that seems unusual.

Drug interaction Lamisil interacts with the following medications: Cyclosporine Metoprolol Nortriptyline Warfarin Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the effect of drugs, so consult your doctor about its interactions.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usual dose next day at the same time regularly.

Overdose Symptoms of Lamisil overdose may include: dizziness, stomach pain, nausea, vomiting, skin rash, or urinating more than usual. If you experience one of them call your doctor immediately.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration date.

Disclaimer We provide only general information about medications that does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Product Description Common use Lamisil is an anti-fungal antibiotic used to treat tinea versicolor, a fungal infection that produces brown, tan, white spots on the trunk of the body or other fungal infections such as athlete's foot, jock itch, and ringworm. Lamisil works by killing sensitive fungi by interfering with the formation of the fungal cell membrane.

Dosage and direction Take it orally with full glass of water. Swallow it without chewing. Usually it taken for 6 to 12 weeks. The recommended dose is different from type of infection: 1. For onychomycosis: Adults and teenagers 250 mg once a day for 6 to 12 weeks. Lamisil is used in children just after doctor's permission. 2. For tinea corporis: Adults and teenagers 250 mg once a day for 2 to 4 weeks. Lamisil is used in children just after doctor's permission. 3. For tinea cruris (ringworm of the groin; jock itch): Adults and teenagers 250 mg once a day for 2 to 4 weeks. Lamisil is used in children just after doctor's permission. 4. For tinea pedis: Adults and teenagers 250 mg once a day for 2 to 6 weeks. Lamisil is used in children just after doctor's permission. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using.

Precautions Before using this medicine, consult your doctor or pharmacist if you have a certain blood disorder or severe liver disease. Don't forget to tell your medical history, especially if it includes lupus. Driving is not recommended while you are taking this medication because it may cause dizziness or less alertness. Drinking alcohol during treatment may cause a fast heartbeat and flushing of the skin. Avoid sun, tanning booths, and sunlamps and use a sunscreen and wear protective clothing when going outdoors. Lamisil should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use before breast-feeding without doctor's advice.

Contraindications Lamisil is not allowed to people who have problems with their liver or kidneys, hypersensitive to any component of this dug.

Possible side effect They may include an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: joint pain or swelling, swollen glands, patchy skin color, or a butterfly-shaped skin rash over your cheeks and nose fever, chills, body aches, flu symptoms; changes in your vision; weight loss due to taste changes; scaly, itchy, and flaky skin rash; fever, sore throat, and headache with a severe blistering, peeling, and red skin rash. Less serious include: stomach pain, heartburn, diarrhea; headache; tired feeling; runny or stuffy nose, sore throat, cold symptoms; mild skin rash or itching; unusual or unpleasant taste in your mouth; or decreased taste sensation. If you experience one of them stop using Lamisil and tell your doctor as soon as possible. Also consult your doctor about any side effect that seems unusual.

Drug interaction Lamisil interacts with the following medications: Cyclosporine Metoprolol Nortriptyline Warfarin Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the effect of drugs, so consult your doctor about its interactions.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usual dose next day at the same time regularly.

Overdose Symptoms of Lamisil overdose may include: dizziness, stomach pain, nausea, vomiting, skin rash, or urinating more than usual. If you experience one of them call your doctor immediately.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration date.

Disclaimer We provide only general information about medications that does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Nitazoxanide (Alinia) Drug Information - Indications, Dosage, Side Effects And Precautions, Netazox

Nitazoxanide - Drug Information

Category B :

Animal studies have failed to demonstrate a risk to the fetus and appropriate studies on pregnant women are lacking.

Dosage & When it is to be taken (Indications):

Oral - Cryptosporidiosis, Giardiasis - Adult: 500 mg every 12 hour for 3 days. Child: 1-3 year: 100 mg every 12 hour; 4-11 year: 200 mg every 12 hour; ≥12 years: 500 mg every 12 hour. All doses to be taken for 3 days.

How it should be taken :

It comes as a tablet and a suspension (liquid) to take by mouth. It is usually taken with food every 12 hours for 3 days.

Warnings and Precautions :

Caution needed for patients with history of HIV, kidney or liver impairment, problems with immune system, children less than 1 year, during pregnancy and breastfeeding.

Side Effects :

Central Nervous System - Headache. Gastrointestinal - Abdominal pain, diarrhea, nausea, vomiting.

Other Precautions :

Take prescribed dose correctly and not to change the dose or discontinue therapy unless advised by your health care provider.

Storage Conditions :

Oral: Suspension: Store it at 15-30?C (59-86?F). Tablet: Store it at room temperature.

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.

What is Nizonide DT. I want to know what is DT? Mintu881 Wednesday, September 25, 2013

Just started taking drug this am and have had my 2nd dose. I'm feeling flu-like. I vomited once and my skin is very sensitive and I have been having wierd pains or feelings. I feel feverish but my husband says I'm not. I feel very physically sensitive. day 1 (pain feelings resemble slightly electrical charges of shingles) Roxannehess Friday, October 15, 2010

Galvus 50 Mg Tablets - Summary Of Product Characteristics (Spc), Galvumet

Description of selected adverse reactions

In controlled clinical trials with the combination of vildagliptin 100 mg daily + metformin, no withdrawal due to adverse reactions was reported in either the vildagliptin 100 mg daily + metformin or the placebo + metformin treatment groups.

In clinical trials, the incidence of hypoglycaemia was common in patients receiving vildagliptin 100 mg daily in combination with metformin (1%) and uncommon in patients receiving placebo + metformin (0.4%). No severe hypoglycaemic events were reported in the vildagliptin arms.

In clinical trials, weight did not change from baseline when vildagliptin 100 mg daily was added to metformin (+0.2 kg and -1.0 kg for vildagliptin and placebo, respectively).

Clinical trials of up to more than 2 years' duration did not show any additional safety signals or unforeseen risks when vildagliptin was added on to metformin.

Combination with a sulphonylurea

Table 2 Adverse reactions reported in patients who received Galvus 50 mg in combination with a sulphonylurea in double-blind studies (N=170)

Infections and infestations

Metabolism and nutrition disorders

Nervous system disorders

Description of selected adverse reactions

In controlled clinical trials with the combination of vildagliptin 50 mg + a sulphonylurea, the overall incidence of withdrawals due to adverse reactions was 0.6% in the vildagliptin 50 mg + sulphonylurea vs 0% in the placebo + sulphonylurea treatment group.

In clinical trials, the incidence of hypoglycaemia when vildagliptin 50 mg once daily was added to glimepiride was 1.2% versus 0.6% for placebo + glimepiride. No severe hypoglycaemic events were reported in the vildagliptin arms.

In clinical trials, weight did not change from baseline when vildagliptin 50 mg daily was added to glimepiride (-0.1 kg and -0.4 kg for vildagliptin and placebo, respectively).

Combination with a thiazolidinedione

Table 3 Adverse reactions reported in patients who received Galvus 100 mg daily in combination with a thiazolidinedione in double-blind studies (N=158)

Metabolism and nutrition disorders

Nervous system disorders

Description of selected adverse reactions

In controlled clinical trials with the combination of vildagliptin 100 mg daily+ a thiazolidinedione, no withdrawal due to adverse reactions was reported in either the vildagliptin 100 mg daily + thiazolidinedione or the placebo + thiazolidinedione treatment groups.

In clinical trials, the incidence of hypoglycaemia was uncommon in patients receiving vildagliptin + pioglitazone (0.6%) but common in patients receiving placebo + pioglitazone (1.9%). No severe hypoglycaemic events were reported in the vildagliptin arms.

In the pioglitazone add-on study, the absolute weight increases with placebo, Galvus 100 mg daily were 1.4 and 2.7 kg, respectively.

The incidence of peripheral oedema when vildagliptin 100 mg daily was added to a maximum dose of background pioglitazone (45 mg once daily) was 7.0%, compared to 2.5% for background pioglitazone alone.

Table 4 Adverse reactions reported in patients who received Galvus 100 mg daily as monotherapy in double-blind studies (N=1,855)

Infections and infestations

Upper respiratory tract infection

Metabolism and nutrition disorders

Nervous system disorders

Musculoskeletal and connective tissue disorders

Description of selected adverse reactions

In addition, in controlled monotherapy trials with vildagliptin the overall incidence of withdrawals due to adverse reactions was no greater for patients treated with vildagliptin at doses of 100 mg daily (0.3%) than for placebo (0.6%) or comparators (0.5%).

In comparative controlled monotherapy studies, hypoglycaemia was uncommon, reported in 0.4% (7 of 1,855) of patients treated with vildagliptin 100 mg daily compared to 0.2% (2 of 1,082) of patients in the groups treated with an active comparator or placebo, with no serious or severe events reported.

In clinical trials, weight did not change from baseline when vildagliptin 100 mg daily was administered as monotherapy (-0.3 kg and -1.3 kg for vildagliptin and placebo, respectively).

Clinical trials of up to 2 years' duration did not show any additional safety signals or unforeseen risks with vildagliptin monotherapy.

Combination with metformin and a sulphonylurea

Table 5 Adverse reactions reported in patients who received Galvus 50 mg twice daily in combination with metformin and a sulphonylurea (N=157)

Metabolism and nutritional disorders

Description of selected adverse reactions

There were no withdrawals due to adverse reactions reported in the vildagliptin + metformin + glimepiride treatment group versus 0.6% in the placebo + metformin + glimepiride treatment group.

The incidence of hypoglycaemia was common in both treatment groups (5.1% for the vildagliptin + metformin + glimepiride group versus 1.9% for the placebo + metformin + glimepiride group). One severe hypoglycaemic event was reported in the vildagliptin group.

At the end of the study, effect on mean body weight was neutral (+0.6 kg in the vildagliptin group and -0.1 kg in the placebo group).

Combination with insulin

Table 6 Adverse reactions reported in patients who received Galvus 100 mg daily in combination with insulin (with or without metformin) in double-blind studies (N=371)

Metabolism and nutrition disorders

Bullous or exfoliative skin lesions

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard.

Information regarding overdose with vildagliptin is limited.

Information on the likely symptoms of overdose was taken from a rising dose tolerability study in healthy subjects given Galvus for 10 days. At 400 mg, there were three cases of muscle pain, and individual cases of mild and transient paraesthesia, fever, oedema and a transient increase in lipase levels. At 600 mg, one subject experienced oedema of the feet and hands, and increases in creatine phosphokinase (CPK), aspartate aminotransferase (AST), C-reactive protein (CRP) and myoglobin levels. Three other subjects experienced oedema of the feet, with paraesthesia in two cases. All symptoms and laboratory abnormalities resolved without treatment after discontinuation of the study medicinal product.

In the event of an overdose, supportive management is recommended. Vildagliptin cannot be removed by haemodialysis. However, the major hydrolysis metabolite (LAY 151) can be removed by haemodialysis.

5. Pharmacological properties

5.1 Pharmacodynamic properties

Pharmacotherapeutic group: Drugs used in diabetes, dipeptidyl peptidase 4 (DPP-4) inhibitors, ATC code: A10BH02

Vildagliptin, a member of the islet enhancer class, is a potent and selective DPP-4 inhibitor.

Mechanism of action

The administration of vildagliptin results in a rapid and complete inhibition of DPP-4 activity, resulting in increased fasting and postprandial endogenous levels of the incretin hormones GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide).

By increasing the endogenous levels of these incretin hormones, vildagliptin enhances the sensitivity of beta cells to glucose, resulting in improved glucose-dependent insulin secretion. Treatment with vildagliptin 50-100 mg daily in patients with type 2 diabetes significantly improved markers of beta cell function including HOMA-β (Homeostasis Model Assessment–β), proinsulin to insulin ratio and measures of beta cell responsiveness from the frequently-sampled meal tolerance test. In non-diabetic (normal glycaemic) individuals, vildagliptin does not stimulate insulin secretion or reduce glucose levels.

By increasing endogenous GLP-1 levels, vildagliptin also enhances the sensitivity of alpha cells to glucose, resulting in more glucose-appropriate glucagon secretion.

The enhanced increase in the insulin/glucagon ratio during hyperglycaemia due to increased incretin hormone levels results in a decrease in fasting and postprandial hepatic glucose production, leading to reduced glycaemia.

The known effect of increased GLP-1 levels delaying gastric emptying is not observed with vildagliptin treatment.

Clinical efficacy and safety

More than 15,000 patients with type 2 diabetes participated in double-blind placebo - or active-controlled clinical trials of up to more than 2 years' treatment duration. In these studies, vildagliptin was administered to more than 9,000 patients at daily doses of 50 mg once daily, 50 mg twice daily or 100 mg once daily. More than 5,000 male and more than 4,000 female patients received vildagliptin 50 mg once daily or 100 mg daily. More than 1,900 patients receiving vildagliptin 50 mg once daily or 100 mg daily were ≥ 65 years. In these trials, vildagliptin was administered as monotherapy in drug-naïve patients with type 2 diabetes or in combination in patients not adequately controlled by other antidiabetic medicinal products.

Overall, vildagliptin improved glycaemic control when given as monotherapy or when used in combination with metformin, a sulphonylurea, and a thiazolidinedione, as measured by clinically relevant reductions in HbA 1c from baseline at study endpoint (see Table 8).

In clinical trials, the magnitude of HbA 1c reductions with vildagliptin was greater in patients with higher baseline HbA 1c .

In a 52-week double-blind controlled trial, vildagliptin (50 mg twice daily) reduced baseline HbA 1c by -1% compared to -1.6% for metformin (titrated to 2 g/day) statistical non-inferiority was not achieved. Patients treated with vildagliptin reported significantly lower incidences of gastrointestinal adverse reactions versus those treated with metformin.

In a 24-week double-blind controlled trial, vildagliptin (50 mg twice daily) was compared to rosiglitazone (8 mg once daily). Mean reductions were -1.20% with vildagliptin and -1.48% with rosiglitazone in patients with mean baseline HbA 1c of 8.7%. Patients receiving rosiglitazone experienced a mean increase in weight (+1.6 kg) while those receiving vildagliptin experienced no weight gain (-0.3 kg). The incidence of peripheral oedema was lower in the vildagliptin group than in the rosiglitazone group (2.1% vs. 4.1% respectively).

In a clinical trial of 2 years' duration, vildagliptin (50 mg twice daily) was compared to gliclazide (up to 320 mg/day). After two years, mean reduction in HbA 1c was -0.5% for vildagliptin and -0.6% for gliclazide, from a mean baseline HBA 1c of 8.6%. Statistical non-inferiority was not achieved. Vildagliptin was associated with fewer hypoglycaemic events (0.7%) than gliclazide (1.7%).

In a 24-week trial, vildagliptin (50 mg twice daily) was compared to pioglitazone (30 mg once daily) in patients inadequately controlled with metformin (mean daily dose: 2020 mg). Mean reductions from baseline HbA 1c of 8.4% were -0.9% with vildagliptin added to metformin and -1.0% with pioglitazone added to metformin. A mean weight gain of +1.9 kg was observed in patients receiving pioglitazone added to metformin compared to +0.3 kg in those receiving vildagliptin added to metformin.

In a clinical trial of 2 years' duration, vildagliptin (50 mg twice daily) was compared to glimepiride (up to 6 mg/day – mean dose at 2 years: 4.6 mg) in patients treated with metformin (mean daily dose: 1894 mg). After 1 year mean reductions in HbA 1c were -0.4% with vildagliptin added to metformin and -0.5% with glimepiride added to metformin, from a mean baseline HbA 1c of 7.3%. Body weight change with vildagliptin was -0.2 kg vs +1.6 kg with glimepiride. The incidence of hypoglycaemia was significantly lower in the vildagliptin group (1.7%) than in the glimepiride group (16.2%). At study endpoint (2 years), the HbA 1c was similar to baseline values in both treatment groups and the body weight changes and hypoglycaemia differences were maintained.

In a 52-week trial, vildagliptin (50 mg twice daily) was compared to gliclazide (mean daily dose: 229.5 mg) in patients inadequately controlled with metformin (metformin dose at baseline 1928 mg/day). After 1 year, mean reductions in HbA 1c were -0.81% with vildagliptin added to metformin (mean baseline HbA 1c 8.4%) and -0.85% with gliclazide added to metformin (mean baseline HbA 1c 8.5%); statistical non-inferiority was achieved (95% CI -0.11 – 0.20). Body weight change with vildagliptin was +0.1 kg compared to a weight gain of +1.4 kg with gliclazide.

In a 24-week trial the efficacy of the fixed dose combination of vildagliptin and metformin (gradually titrated to a dose of 50 mg/500 mg twice daily or 50 mg/1000 mg twice daily) as initial therapy in drug-naïve patients was evaluated. Vildagliptin/metformin 50 mg/1000 mg twice daily reduced HbA 1c by -1.82%, vildagliptin/metformin 50 mg/500 mg twice daily by -1.61%, metformin 1000 mg twice daily by -1.36% and vildagliptin 50 mg twice daily by -1.09% from a mean baseline HbA 1c of 8.6%. The decrease in HbA 1c observed in patients with a baseline ≥10.0% was greater.

A 24-week, multi-centre, randomised, double-blind, placebo-controlled trial was conducted to evaluate the treatment effect of vildagliptin 50 mg once daily compared to placebo in 515 patients with type 2 diabetes and moderate renal impairment (N=294) or severe renal impairment (N=221). 68.8% and 80.5% of the patients with moderate and severe renal impairment respectively were treated with insulin (mean daily dose of 56 units and 51.6 units respectively) at baseline. In patients with moderate renal impairment vildagliptin significantly decreased HbA 1c compared with placebo (difference of -0.53%) from a mean baseline of 7.9%. In patients with severe renal impairment, vildagliptin significantly decreased HbA 1c compared with placebo (difference of -0.56%) from a mean baseline of 7.7%.

A 24-week randomised, double-blind, placebo-controlled trial was conducted in 318 patients to evaluate the efficacy and safety of vildagliptin (50 mg twice daily) in combination with metformin (≥1500 mg daily) and glimepiride (≥4 mg daily). Vildagliptin in combination with metformin and glimepiride significantly decreased HbA 1c compared with placebo. The placebo-adjusted mean reduction from a mean baseline HbA 1c of 8.8% was -0.76%.

A 24-week randomised, double-blind, placebo-controlled trial was conducted in 449 patients to evaluate the efficacy and safety of vildagliptin (50 mg twice daily) in combination with a stable dose of basal or premixed insulin (mean daily dose 41 units), with concomitant use of metformin (N=276) or without concomitant metformin (N=173). Vildagliptin in combination with insulin significantly decreased HbA 1c compared with placebo. In the overall population, the placebo-adjusted mean reduction from a mean baseline HbA 1c 8.8% was -0.72%. In the subgroups treated with insulin with or without concomitant metformin the placebo-adjusted mean reduction in HbA 1c was -0.63% and -0.84%, respectively. The incidence of hypoglycaemia in the overall population was 8.4% and 7.2% in the vildagliptin and placebo groups, respectively. Patients receiving vildagliptin experienced no weight gain (+0.2 kg) while those receiving placebo experienced weight reduction (-0.7 kg).

In another 24-week study in patients with more advanced type 2 diabetes not adequately controlled on insulin (short and longer acting, average insulin dose 80 IU/day), the mean reduction in HbA 1c when vildagliptin (50 mg twice daily) was added to insulin was statistically significantly greater than with placebo plus insulin (0.5% vs. 0.2%). The incidence of hypoglycaemia was lower in the vildagliptin group than in the placebo group (22.9% vs. 29.6%).

A 52-week multi-centre, randomised, double-blind trial was conducted in patients with type 2 diabetes and congestive heart failure (NYHA functional class I-III) to evaluate the effect of vildagliptin 50 mg twice daily (N=128) compared to placebo (N=126) on left-ventricular ejection fraction (LVEF). Vildagliptin was not associated with a change in left-ventricular function or worsening of pre-existing CHF. Adjudicated cardiovascular events were balanced overall. There were more cardiac events in vildagliptin treated patients with NYHA class III heart failure compared to placebo. However, there were imbalances in baseline cardiovascular risk favouring placebo and the number of events was low, precluding firm conclusions. Vildagliptin significantly decreased HbA1c compared with placebo (difference of 0.6%) from a mean baseline of 7.8% at week 16. In the subgroup with NYHA class III, the decrease in HbA1c compared to placebo was lower (difference 0.3%) but this conclusion is limited by the small number of patients (n=44). The incidence of hypoglycaemia in the overall population was 4.7% and 5.6% in the vildagliptin and placebo groups, respectively.

A meta-analysis of independently and prospectively adjudicated cardiovascular events from 25 phase III clinical studies of up to more than 2 years duration was performed and showed that vildagliptin treatment was not associated with an increase in cardiovascular risk versus comparators. The composite endpoint of adjudicated cardiovascular and cerebrovascular (CCV) events [acute coronary syndrome (ACS), transient ischaemic attack (with imaging evidence of infarction), stroke or CCV death], was similar for vildagliptin versus combined active and placebo comparators [Mantel–Haenszel risk ratio 0.84 (95% confidence interval 0.63-1.12)]. In total, 99 out of 8956 patients reported an event in the vildagliptin group vs 91 out of 6061 patients in the comparator group.

Table 8 Key efficacy results of vildagliptin in placebo-controlled monotherapy trials and in add-on combination therapy trials (primary efficacy ITT population)

Monotherapy placebo controlled studies

The European Medicines Agency has waived the obligation to submit the results of studies with vildagliptin in all subsets of the paediatric population with type 2 diabetes mellitus (see section 4.2 for information on paediatric use).

5.2 Pharmacokinetic properties

Following oral administration in the fasting state, vildagliptin is rapidly absorbed, with peak plasma concentrations observed at 1.7 hours. Food slightly delays the time to peak plasma concentration to 2.5 hours, but does not alter the overall exposure (AUC). Administration of vildagliptin with food resulted in a decreased C max (19%). However, the magnitude of change is not clinically significant, so that Galvus can be given with or without food. The absolute bioavailability is 85%.

The plasma protein binding of vildagliptin is low (9.3%) and vildagliptin distributes equally between plasma and red blood cells. The mean volume of distribution of vildagliptin at steady-state after intravenous administration (V ss ) is 71 litres, suggesting extravascular distribution.

Metabolism is the major elimination pathway for vildagliptin in humans, accounting for 69% of the dose. The major metabolite (LAY 151) is pharmacologically inactive and is the hydrolysis product of the cyano moiety, accounting for 57% of the dose, followed by the glucuronide (BQS867) and the amide hydrolysis products (4% of dose). In vitro data in human kidney microsomes suggest that the kidney may be one of the major organs contributing to the hydrolysis of vildagliptin to its major inactive metabolite, LAY151. DPP-4 contributes partially to the hydrolysis of vildagliptin based on an in vivo study using DPP-4 deficient rats. Vildagliptin is not metabolised by CYP 450 enzymes to any quantifiable extent. Accordingly, the metabolic clearance of vildagliptin is not anticipated to be affected by co-medications that are CYP 450 inhibitors and/or inducers. In vitro studies demonstrated that vildagliptin does not inhibit/induce CYP 450 enzymes. Therefore, vildagliptin is not likely to affect metabolic clearance of co-medications metabolised by CYP 1A2, CYP 2C8, CYP 2C9, CYP 2C19, CYP 2D6, CYP 2E1 or CYP 3A4/5.

Following oral administration of [ 14 C] vildagliptin, approximately 85% of the dose was excreted into the urine and 15% of the dose is recovered in the faeces. Renal excretion of the unchanged vildagliptin accounted for 23% of the dose after oral administration. After intravenous administration to healthy subjects, the total plasma and renal clearances of vildagliptin are 41 and 13 l/h, respectively. The mean elimination half-life after intravenous administration is approximately 2 hours. The elimination half-life after oral administration is approximately 3 hours.

The C max for vildagliptin and the area under the plasma concentrations versus time curves (AUC) increased in an approximately dose proportional manner over the therapeutic dose range.

Characteristics in specific groups of patients

No clinically relevant differences in the pharmacokinetics of vildagliptin were observed between male and female healthy subjects within a wide range of age and body mass index (BMI). DPP-4 inhibition by vildagliptin is not affected by gender.

In healthy elderly subjects (≥ 70 years), the overall exposure of vildagliptin (100 mg once daily) was increased by 32%, with an 18% increase in peak plasma concentration as compared to young healthy subjects (18-40 years). These changes are, however, not considered to be clinically relevant. DPP-4 inhibition by vildagliptin is not affected by age.

The effect of impaired hepatic function on the pharmacokinetics of vildagliptin was studied in patients with mild, moderate and severe hepatic impairment based on the Child-Pugh scores (ranging from 6 for mild to 12 for severe) in comparison with healthy subjects. The exposure to vildagliptin after a single dose in patients with mild and moderate hepatic impairment was decreased (20% and 8%, respectively), while the exposure to vildagliptin for patients with severe impairment was increased by 22%. The maximum change (increase or decrease) in the exposure to vildagliptin is

30%, which is not considered to be clinically relevant. There was no correlation between the severity of the hepatic disease and changes in the exposure to vildagliptin.

A multiple-dose, open-label trial was conducted to evaluate the pharmacokinetics of the lower therapeutic dose of vildagliptin (50 mg once daily) in patients with varying degrees of chronic renal impairment defined by creatinine clearance (mild: 50 to <80 ml/min, moderate: 30 to <50 ml/min and severe: <30 ml/min) compared to normal healthy control subjects.

Vildagliptin AUC increased on average 1.4, 1.7 and 2-fold in patients with mild, moderate and severe renal impairment, respectively, compared to normal healthy subjects. AUC of the metabolites LAY151 and BQS867 increased on average about 1.5, 3 and 7-fold in patients with mild, moderate and severe renal impairment, respectively. Limited data from patients with end stage renal disease (ESRD) indicate that vildagliptin exposure is similar to that in patients with severe renal impairment. LAY151 concentrations were approximately 2-3-fold higher than in patients with severe renal impairment.

Vildagliptin was removed by haemodialysis to a limited extent (3% over a 3-4 hour haemodialysis session starting 4 hours post dose).

Limited data suggest that race does not have any major influence on vildagliptin pharmacokinetics.

5.3 Preclinical safety data

Intra-cardiac impulse conduction delays were observed in dogs with a no-effect dose of 15 mg/kg (7-fold human exposure based on C max ).

Accumulation of foamy alveolar macrophages in the lung was observed in rats and mice. The no-effect dose in rats was 25 mg/kg (5-fold human exposure based on AUC) and in mice 750 mg/kg (142-fold human exposure).

Gastrointestinal symptoms, particularly soft faeces, mucoid faeces, diarrhoea and, at higher doses, faecal blood were observed in dogs. A no-effect level was not established.

Vildagliptin was not mutagenic in conventional in vitro and in vivo tests for genotoxicity.

A fertility and early embryonic development study in rats revealed no evidence of impaired fertility, reproductive performance or early embryonic development due to vildagliptin. Embryo-foetal toxicity was evaluated in rats and rabbits. An increased incidence of wavy ribs was observed in rats in association with reduced maternal body weight parameters, with a no-effect dose of 75 mg/kg (10-fold human exposure). In rabbits, decreased foetal weight and skeletal variations indicative of developmental delays were noted only in the presence of severe maternal toxicity, with a no-effect dose of 50 mg/kg (9-fold human exposure). A pre - and postnatal development study was performed in rats. Findings were only observed in association with maternal toxicity at ≥ 150 mg/kg and included a transient decrease in body weight and reduced motor activity in the F1 generation.

A two-year carcinogenicity study was conducted in rats at oral doses up to 900 mg/kg (approximately 200 times human exposure at the maximum recommended dose). No increases in tumour incidence attributable to vildagliptin were observed. Another two-year carcinogenicity study was conducted in mice at oral doses up to 1,000 mg/kg. An increased incidence of mammary adenocarcinomas and haemangiosarcomas was observed with a no-effect dose of 500 mg/kg (59-fold human exposure) and 100 mg/kg (16-fold human exposure), respectively. The increased incidence of these tumours in mice is considered not to represent a significant risk to humans based on the lack of genotoxicity of vildagliptin and its principal metabolite, the occurrence of tumours only in one species and the high systemic exposure ratios at which tumours were observed.

In a 13-week toxicology study in cynomolgus monkeys, skin lesions have been recorded at doses ≥ 5 mg/kg/day. These were consistently located on the extremities (hands, feet, ears and tail). At 5 mg/kg/day (approximately equivalent to human AUC exposure at the 100 mg dose), only blisters were observed. They were reversible despite continued treatment and were not associated with histopathological abnormalities. Flaking skin, peeling skin, scabs and tail sores with correlating histopathological changes were noted at doses ≥ 20 mg/kg/day (approximately 3 times human AUC exposure at the 100 mg dose). Necrotic lesions of the tail were observed at ≥ 80 mg/kg/day. Skin lesions were not reversible in the monkeys treated at 160 mg/kg/day during a 4-week recovery period.

6. Pharmaceutical particulars

6.1 List of excipients

Neovisc - Help Prevent The Pain Of Osteoarthritis, Neovisc

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has written 480 post in this blog.

NeoVisc (Sodium Hyaluronate) injections are one way to prevent the pain caused by osteoarthritis in your knees. NeoVisc is a viscosupplement (lubricant) that can be injected into your knee to reduce the pain that occurs when your knee moves. NeoVisc is a 1.0% solution of high-purity sodium hyaluronate. To explain it in the simplest terms, NeoVisc is the WD-40 you add to a rusty hinge.

Osteoarthritis is a type of arthritis that occurs when the cartilage between your joints breaks down. Cartilage acts as the cushion between your joints. As the cartilage breaks down, your joints start rubbing together causing inflammation and pain. The most common areas affected by osteoarthritis are your hands, feet, spine, and large weight-bearing joints, like your knees or hips. Unfortunately, there is no cure for osteoarthritis. but with treatment you can prevent the pain and suffering.

Directions for using NeoVisc

NeoVisc should be injected by a trained professional at a clinic or hospital. All orders of NeoVisc come with an information pamphlet. Please read the pamphlet and ask any questions prior receiving NeoVisc injection treatments.

NeoVisc treatments consist of three injections into the synocial space of your knee joint. These injections are called intra-articular injections. You will receive one injection per week for three weeks.

Optimal results are usually seen within thirty days after the last NeoVisc injection, but some patients experience improvements after the second injection. Patients experience up to eight months of pain relief. In some cases, the NeoVisc injections can stimulate the growth of natural healthy hyaluronate.

General guidelines for NeoVisc

Store NeoVisc below 86 degrees F (30 degrees C).

Store NeoVisc in the original packaging.

Store NeoVisc away from light.

Do not freeze NeoVisc.

Take NeoVisc on time (If you miss an appointment, notify your doctor as soon as possible).

Side Effects of NeoVisc

All patients should complete the full treatment course, even if you are start feeling better. It is important to keep a regular schedule for your NeoVisc injections.

Avoid using certain skin disinfectants (containing ammonium salts).

Pregnant females should discuss NeoVisc with a physician. It is unknown if this medicine is excreted in breast milk.

Is a Prescription needed for NeoVisc?

Why would I choose NeoVisc over other viscosupplements?

Tests show that there are no significant differences in treatment outcome with NeoVisc as compared to other hyaluronate products, but NeoVisc can cost up to 50% less than other products.

DoctorSolve Healthcare Solutions Inc. a Canadian Internet-based pharmacy intermediary (license #BC X23), offers low cost, long-term prescription drugs. A professionally registered pharmacist fills all Canadian prescriptions. A certified member of the Canadian International Pharmacy Association, DoctorSolve is ranked as one of the best online Canadian pharmacies by PharmacyChecker. com. For more information on how to order Canada drugs safely and securely call 1-866-732-0305 or visit http://www. doctorsolve. com/ – a trusted and reliable Canadian online pharmacy since 1999.

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Cdc - Lithium Carbonate - International Chemical Safety Cards, Hypnorex

LITHIUM CARBONATE

PHYSICAL STATE; APPEARANCE: WHITE POWDER

CHEMICAL DANGERS: The solution in water is a weak base. Reacts violently with fluorine.

OCCUPATIONAL EXPOSURE LIMITS: TLV not established.

ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

EFFECTS OF SHORT-TERM EXPOSURE: The substance irritates the eyes, the skin and the respiratory tract. The substance may cause effects on the central nervous system.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the central nervous system and the kidneys. May cause reproductive toxicity in humans.

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Singulair (Astmirex)

Singulair is used for prevention and long-term treatment of asthma. It is also used in certain patients to relieve runny nose caused by allergies and to prevent asthma attacks caused by exercise. Singulair is a leukotriene receptor antagonist. It works by blocking a substance called leukotriene, which helps to decrease certain asthma and allergy symptoms.

Use Singulair as directed by your doctor.

Take Singulair by mouth with or without food.

Continue to use Singulair even if you feel well. Do not miss any doses.

If you miss a dose of Singulair, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Singulair.

Store Singulair at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Singulair out of the reach of children and away from pets.

Active Ingredient: Montelukast sodium.

Do NOT use Singulair if:

you are allergic to any ingredient in Singulair.

Contact your doctor right away if any of these apply to you.

Some medical conditions may interact with Singulair. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have liver problems

if you have a history of mental or mood problems, or suicidal thoughts or actions.

Some medicines may interact with Singulair. Tell your health care provider if you are taking any other medicines, especially any of the following:

Certain anticonvulsants (eg, phenobarbital) or rifampin because they may decrease Singulair's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Singulair may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Singulair may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Singulair with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Singulair will not stop an asthma attack once one has started. Be sure you always carry appropriate medicine (eg, bronchodilator inhalers) with you in case of an asthma attack.

Contact your doctor promptly if your short-acting inhaler use increases or if use exceeds the 24-hour maximum prescribed by your doctor. Contact your doctor if your asthma worsens.

Do not decrease your dose or stop using Singulair or other asthma medicines without first checking with your doctor.

If your asthma is sensitive to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), continue to avoid those medicines as directed by your doctor.

Some patients taking Singulair have developed mental or mood changes, including suicidal thoughts or actions. Contact your doctor immediately if you experience symptoms such as agitation, aggression, hostility, anxiety, depression, strange dreams, trouble sleeping, sleepwalking, tremor, hallucinations, restlessness, irritability, or any unusual change in mood or behavior. Contact your doctor immediately if any signs of suicidal thoughts or actions occur.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor right away. You will need to discuss the benefits and risks of using Singulair while you are pregnant. It is not known if Singulair is found in breast milk. If you are or will be breast-feeding while you use Singulair, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Cough; dizziness; headache; indigestion; nausea; stomach upset or pain; stuffy nose; tiredness; trouble sleeping; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); aggressive behavior; agitation; chest pain; dark urine; fever; flu-like symptoms; hallucinations; irregular heartbeat; mental or mood changes; new or worsening wheezing or other breathing problems; numbness or tingling of the hands or feet; seizures; severe or persistent stomach pain; severe sinus inflammation; suicidal thoughts or actions; swelling; tremor; unusual bruising or bleeding; upper respiratory tract infection; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Tenormin (Docatone)

Tenormin is used to treat angina (chest pain) and hypertension (high blood pressure). Tenormin is used for decreasing death due to heart problems after a heart attack. Tenormin is a beta-blocker. Exactly how Tenormin works to decrease heart problems after a heart attack is not known.

Use Tenormin as directed by your doctor.

Do not take Tenormin in larger amounts or for longer than recommended by your doctor.

Take Tenormin with a full glass of water.

Take Tenormin at the same time every day.

Do not skip doses or stop taking Tenormin without first talking to your doctor. Stopping suddenly may make your condition worse.

To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. It is important that you not miss any scheduled visits to your doctor.

If you need to have any type of surgery, tell the surgeon that you are using Tenormin. You may need to briefly stop using Tenormin before having surgery.

Tenormin is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.

Hypertension often has no symptoms, so you may not even feel that you have high blood pressure. Continue using this medicine as directed, even if you feel well. You may need to use blood pressure medication for the rest of your life.

Ask your health care provider any questions you may have about how to use Tenormin.

Store Tenormin at room temperature away from moisture and heat. Keep Tenormin out of the reach of children and away from pets.

Active Ingredient: Atenolol.

Do NOT use Tenormin if:

you are allergic to any ingredient in Tenormin

you have a very slow heartbeat, heart block, uncontrolled heart failure, shock caused by serious heart problems, or low blood pressure after a heart attack

you have an untreated adrenal gland tumor (pheochromocytoma)

you are taking mibefradil.

Contact your doctor or health care provider right away if any of these apply to you.

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of any severe allergic reaction

if you have a history of lung or breathing problems (eg, asthma, chronic bronchitis, chronic obstructive pulmonary disease [COPD], emphysema), heart problems (eg, heart failure, conduction problems, left ventricle problems), blood vessel problems, diabetes, kidney problems, an adrenal gland tumor, or an overactive thyroid.

Some medicines may interact with Tenormin. Tell your health care provider if you are taking any of the following medicines.

Clonidine because the risk of severe high blood pressure may be increased

Mefloquine because the risk of irregular heartbeat may be increased

Amiodarone, calcium channel blockers (eg, diltiazem, verapamil), catecholamine-depleting medicines (eg, reserpine), digoxin, disopyramide, flecainide, ketanserin, mibefradil, or quinidine because they may increase the risk of Tenormin's side effects

Indomethacin or phenylpropanolamine because it may decrease Tenormin's effectiveness

Bupivacaine, lidocaine, or quinazolines (eg, alfuzosin) because the risk of their side effects may be increased by Tenormin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tenormin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Tenormin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Tenormin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Tenormin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Tell your doctor or dentist that you take Tenormin before you receive any medical or dental care, emergency care, or surgery.

Tenormin may reduce the amount of blood that flows to your feet and hands. This may cause them to feel cold and make you more sensitive to the cold. Dress warmly in cold weather. Be careful when you are out in the cold for long periods of time. Ask you doctor for more information.

If you have a history of any severe allergic reaction, talk with your doctor. You may be at risk for an even more severe allergic reaction if you come into contact with the substance that caused your allergy. Some medicines used to treat severe allergies may also not work as well while you are using Tenormin.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

Diabetes patients - Tenormin may hide signs of low blood sugar such as a rapid heartbeat. Other symptoms, such as sweating, may still occur. Check your blood sugar levels regularly. Ask your doctor before you change the dose of your diabetes medicine.

Check your blood pressure and pulse regularly, as directed by your doctor. Ask your doctor or pharmacist for help if you are unsure how to properly measure your blood pressure or pulse.

Lifestyle changes may also help reduce your blood pressure. Talk with your doctor about appropriate diet and exercise programs that may be helpful to you.

Lab tests, including blood pressure and heart function tests, may be performed while you use Tenormin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Tenormin with caution in the elderly; they may be more sensitive to its effects, especially dizziness.

Tenormin should be used with extreme caution in children; safety and effectiveness in children have not been determined.

Pregnancy and breast-feeding: Tenormin has been shown to cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tenormin while you are pregnant. Tenormin is found in breast milk. If you are or will be breast-feeding while you use Tenormin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Cold fingers and toes; diarrhea; dizziness; drowsiness; nausea; tiredness or weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blue fingernails, toenails, or palms; decreased sexual ability; fainting; mental or mood problems; persistent dizziness or lightheadedness; shortness of breath; sudden, unusual weight gain; swelling of hands, ankles, or feet; unusual bruising or bleeding; unusually slow heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Tizanidina Medlineplus Medicinas, Tizanidina

Tizanidina

?Para cuales condiciones o enfermedades se prescribe este medicamento?

La tizanidina se usa para aliviar los espasmos y el aumento del tono muscular ocasionado por los accidentes cerebrovasculares, las lesiones cerebrales o de la medula espinal y la esclerosis multiple (MS, por sus siglas en ingles, una enfermedad en la que los nervios no funcionan adecuadamente y los pacientes pueden sufrir debilidad, entumecimiento, perdida de la coordinacion muscular y problemas de la vista, del habla y del control urinario). La tizanidina pertenece a una clase de medicamentos llamados relajantes del musculo esqueletico. Funciona al hacer mas lenta la accion del cerebro y del sistema nervioso para permitir que los musculos se relajen.

?Como se debe usar este medicamento?

La presentacion de la tizanidina son tabletas y capsulas para administrarse por via oral. Suele tomarse dos o tres veces al dia, ya sea siempre con alimentos o siempre sin ellos. Siga cuidadosamente las instrucciones de la receta y pidales a su medico o farmaceutico que le expliquen cualquier cosa que no entienda. Tome la tizanidina segun lo indicado. No aumente ni disminuya la dosis, ni la tome con mas frecuencia que la indicada por su medico.

Las capsulas de tizanidina pueden abrirse y espolvorearse su contenido sobre alimentos blandos como la compota de manzana. Hable con su medico antes de abrir las capsulas, pues los efectos del medicamento cuando se toma de esta manera pueden ser diferentes que cuando se traga la capsula entera.

El cuerpo absorbe el medicamento de la capsula de modo distinto que el de la tableta, asi que no debe tomarse un producto por otro. Cada vez que le surtan su receta, vea si el frasco contiene tabletas o capsulas y cerciorese de que le hayan dado el producto correcto. Si cree que le dieron un medicamento por otro, consulte de inmediato a su medico o farmaceutico.

Probablemente el medico le recete al principio una dosis baja de tizanidina y luego la aumente de manera gradual, dependiendo de su respuesta a este medicamento.

No deje de tomar la tizanidina sin consultar antes a su medico. Si deja de tomar subitamente la tizanidina, es posible que el corazon le palpite mas rapido y aumente su presion arterial o los musculos se contraigan. Es probable que el medico opte por disminuir gradualmente la dosis.

?Que otro uso se le da a este medicamento?

A veces se receta este medicamento para otros usos; pidales mas informacion a su medico o farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes de tomar tizanidina,

digales a su medico y a su farmaceutico si es alergico a la tizanidina o a cualquier otro medicamento.

avisele a su medico si esta tomando ciprofloxacina (Cipro) o fluvoxamina. Probablemente su medico le dira que no tome tizanidina si esta tomando cualquiera de esos medicamentos.

digales a su medico y a su farmaceutico que otros medicamentos con y sin receta, vitaminas, suplementos nutricionales y productos herbales esta tomando o piensa tomar. No olvide mencionar ninguno de los siguientes: aciclovir (Zovirax); amiodarona (Cordarone, Pacerone); baclofeno; cimetidina (Tagamet); clonidina (Catapres, Catapres-TTS); dantroleno (Dantrium); diazepam (Valium); famotidina (Pepcid, Pepcid AC); medicamentos contra la ansiedad, las convulsiones o la presion arterial alta; mexiletina (Mexitil); anticonceptivos orales (pildoras anticonceptivas); propafenona (Rythmol); fluoroquinolonas como gemifloxacina (Factive), levofloxacina (Levaquin), moxifloxacina (Avelox), norfloxacina (Noroxin) y ofloxacina (Floxin); ticlopidina (Ticlid); sedantes; pastillas para dormir; tranquilizantes; verapamilo (Calan, Covera, Isoptin, Verelan); y zileuton (Zyflo). Es posible que su medico deba cambiar la dosis de sus medicamentos o vigilarle estrechamente por si presentara efectos secundarios. Hay otros medicamentos que pueden interactuar con la tizanidina, asi que no olvide decirle a su medico todos los medicamentos que esta tomando, inclusive los que no aparecen en esta lista.

digale a su medico si tiene o ha tenido alguna enfermedad del rinon o del higado.

digale a su medico si esta embarazada, planea estarlo o esta dando el pecho. Si queda embarazada mientras esta tomando tizanidina, llame a su medico.

si le van a hacer una cirugia, incluyendo una cirugia dental, digale al medico o al dentista que esta tomando tizanidina.

tenga en cuenta que este medicamento puede causar somnolencia. Evite conducir vehiculos u operar maquinaria hasta que no sepa como le afecta este medicamento.

recuerde que el alcohol puede aumentar la somnolencia que este medicamento provoca.

tenga presente que la tizanidina puede provocarle mareo, vertigo y desmayos si se levanta demasiado rapido despues de estar acostado. Esto es mas comun cuando se empieza a tomar la tizanidina. Para evitar este problema, levantese de la cama lentamente y apoye los pies en el piso unos minutos antes de ponerse de pie. la tizanidina puede disminuir el tono muscular, asi que debe tener cuidado al caminar o hacer otras actividades que dependen del tono muscular para ayudarle a mantener la postura o el equilibrio.

?Que dieta especial debo seguir mientras tomo este medicamento?

A menos que su medico le indique lo contrario, continue con su dieta normal.

?Que tengo que hacer si me olvido de tomar una dosis?

Si su medico le dijo que tomara tizanidina con regularidad, cuando olvide una dosis tomela en cuanto se acuerde. No obstante, si ya casi es hora de la dosis siguiente, salte la que olvido y continue con su horario de medicacion normal. No tome una dosis doble para compensar la que olvido.

?Cuales son los efectos secundarios que podria provocar este medicamento?

La tizanidina puede provocar efectos secundarios. Avisele a su medico si cualquiera de estos sintomas es grave o no desaparece:

mareo

somnolencia

debilidad

nerviosismo

depresion

vomito

sensacion de hormigueo en los brazos, las piernas, las manos y los pies

boca seca

estrenimiento

diarrea

dolor de estomago

acidez estomacal

aumento de los espasmos musculares

dolor de espalda

sarpullido

sudoracion

Algunos efectos secundarios pueden ser graves. Si presenta alguno de estos sintomas, llame a su medico de inmediato:

nausea

cansancio extremo

sangrado o moretones anormales

falta de energia

perdida del apetito

dolor en la parte superior derecha del estomago

coloracion amarilla de la piel o los ojos

sintomas parecidos a los de la gripe, sin razon aparente

ver cosas o escuchar voces que no existen

latidos cardiacos lentos

cambios en la vista

La tizanidina puede provocar otros efectos secundarios. Llame a su medico si tiene algun problema inesperado mientras toma este medicamento.

Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgacion de efectos adversos 'MedWatch' de la Administracion de Alimentos y Medicamentos (FDA, por su sigla en ingles) en la pagina de Internet (http://www. fda. gov/Safety/MedWatch ) o por telefono al 1-800-332-1088.

?Como debo almacenar o desechar este medicamento?

Mantenga este producto en su envase original, perfectamente cerrado y fuera del alcance de los ninos. Guardelo a temperatura ambiente y en un lugar alejado del exceso de calor y humedad (nunca en el cuarto de bano).

Los medicamentos que ya no son necesarios se deben desechar de una manera apropiada para asegurarse de que las mascotas, los ninos y otras personas no puedan consumirlos. Sin embargo, no debe desechar estos medicamentos por el inodoro. En su lugar, la mejor manera de deshacerse de sus medicamentos es a traves de un programa de devolucion de medicamentos. Hable con su farmaceutico o pongase en contacto con su departamento de basura/reciclaje local para conocer acerca de los programas de devolucion de medicamentos de su comunidad. Consulte el sitio web de la Administracion de Medicamentos y Alimentos (FDA), (http://goo. gl/c4Rm4p ) para obtener mas informacion de como desechar de forma segura los medicamentos, si no tiene acceso al programa de devolucion de medicamentos.

?Que debo hacer en caso de una sobredosis?

En caso de una sobredosis, llame a la oficina local de control de envenenamiento al 1-800-222-1222. Si la victima esta inconsciente, o no respira, llame inmediatamente al 911.

Los sintomas de sobredosis son, entre otros:

somnolencia

cansancio extremo

confusion

latidos cardiacos lentos

desvanecimiento

mareo

respiracion lenta o superficial

perdida del conocimiento

?Que otra informacion de importancia deberia saber?

No falte a ninguna cita con su medico y con el laboratorio. Su medico ordenara ciertas pruebas de laboratorio para ver como responde a la tizanidina.

No deje que ninguna otra persona use sus medicamentos. Preguntele a su farmaceutico como puede volver a surtir su receta.

Es importante que Ud. mantenga una lista escrita de todas las medicinas que Ud. esta tomando, incluyendo las que recibio con receta medica y las que Ud. compro sin receta, incluyendo vitaminas y suplementos de dieta. Ud. debe tener la lista cada vez que visita su medico o cuando es admitido a un hospital. Tambien es una informacion importante en casos de emergencia.

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Farlac Rezeptfrei Kaufen ? Qualitat; ? Mit Niedrigen Preisen; ? Lieferung, Farlac

Duphalac wird verwendet, um chronische Verstopfung behandeln.

Nehmen Sie dieses Medikament genau wie von Ihrem Arzt verordnet. Nehmen Sie es nicht in gro?eren Mengen oder langer als empfohlen. Befolgen Sie die Anweisungen auf dem Etikett Verschreibung.

Messen flussiger Medizin mit einer speziellen Dosis-Messloffel oder Tasse, nicht regelma?ig Tafelloffel. Wenn Sie nicht uber eine Dosis-Messgerat, fragen Sie Ihren Apotheker fur einen.

Die flussige Form von Lactulose kann etwas dunkler in der Farbe geworden, aber das ist eine harmlose Wirkung. Allerdings mussen Sie das Medikament nicht, wenn es sehr dunkel ist, oder wenn es dicker oder dunner in der Textur.

Lactulose Pulver sollte mit mindestens 4 Unzen Wasser gemischt werden. Sie konnen auch Fruchtsaft oder Milch, um die Medikamente besser.

Es kann bis zu 48 Stunden, bevor Sie einen Stuhlgang nach der Einnahme von Lactulose haben.

Wenn Sie Lactulose uber einen langeren Zeitraum verwenden, kann Ihr Arzt mochte, dass du gelegentlich Blutuntersuchungen haben. Verpassen Sie keine Termine geplant.

Wenn Sie eine Dosis verpasst haben - nehmen Sie die vergessene Dosis so bald wie Sie sich erinnern. Wenn es fast Zeit fur Ihre nachste Dosis ist, warten, bis dann die Medizin zu nehmen und die verpasste Dosis. Nehmen Sie keine zusatzlichen Medikamente, um die vergessene Dosis.

Nehmen Sie dieses Medikament genau wie von Ihrem Health Provider vorgeschrieben.

Store an der Raumtemperatur weg von der Feuchtigkeit und Sonneneinstrahlung. Halten Sie au?erhalb der Reichweite von Kindern und Haustieren.

Lactulose ist ein Typ von Zucker. Es sich im Dickdarm in leichte Sauren, Wasser zu schopfen in den Dickdarm gebrochen, hilft die erweichen die Stuhle.

Sie sollten nicht diese Medikation, wenn Sie eine besondere Diat Galactose (Milchzucker).

Vor der Einnahme von Lactulose, informieren Sie Ihren Arzt, wenn Sie Diabetes haben, oder wenn Sie brauchen, um jede Art von Darm-Test mit einem Umfang (wie eine Koloskopie) haben.

Stop mit Lactulose und rufen Sie Ihren Arzt auf, wenn Sie an einer schweren oder anhaltenden Durchfall haben.

Die flussige Form von Lactulose kann etwas dunkler in der Farbe geworden, aber das ist eine harmlose Wirkung. Allerdings mussen Sie das Medikament nicht, wenn es sehr dunkel ist, oder wenn es dicker oder dunner in der Textur.

Wenn Sie Lactulose uber einen langeren Zeitraum verwenden, kann Ihr Arzt mochte, dass du gelegentlich Blutuntersuchungen haben. Verpassen Sie keine Termine geplant.

FDA Schwangerschaft Kategorie B. Dieses Medikament ist nicht zu erwarten, als schadlich fur ein ungeborenes Kind. Informieren Sie Ihren Arzt, wenn Sie schwanger sind oder planen, wahrend der Behandlung schwanger werden. Es ist nicht bekannt, ob Lactulose in die Muttermilch ubergeht oder ob es ein Saugling schaden. Verwenden Sie nicht diese Medikation ohne erzahlen Sie Ihren Arzt, wenn Sie stillen ein Baby.

Vermeiden Sie die Verwendung Antazida ohne den Rat Ihres Arztes. Verwenden Sie nur die spezifische Art von Antazida Ihr Arzt empfiehlt. Antazida enthalten verschiedene Medikamente und einige Arten kann es schwieriger fur den Korper zu Lactulose absorbieren.

Erhalten Sie Notfall medizinische Hilfe, wenn Sie eines dieser Anzeichen einer allergischen Reaktion: Nesselsucht, Atembeschwerden, Schwellungen von Gesicht, Lippen, Zunge oder Rachen. Stop mit Lactulose und rufen Sie Ihren Arzt auf, wenn Sie an einer schweren oder anhaltenden Durchfall haben.

Weniger schwerwiegende Nebenwirkungen gehoren: Blahungen, Bauchschmerzen, Durchfall, Ubelkeit oder Erbrechen.

Dies ist keine vollstandige Liste der Nebenwirkungen und andere auftreten. Informieren Sie Ihren Arzt uber alle ungewohnlichen oder lastigen Nebeneffekt.

Kunden, die diesen Artikel gekauft haben, schaffen auch folgende Artikel an.

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Buy Hyaludermin - Hyaluronic Acid - Online Without Prescriptions, Hyaludermin

Hyaluronic Acid (Hyaludermin)

Hyaluronic Acid enhances proteoglycans in the joint matrix, thereby providing support for healthy joint function and maintaining joint shock absorption and cushioning.

As a dietary supplement, take 2 capsules daily, or as directed by a health care practitioner. Take with 8-10 ounces of water, with or without food.

Consult your Health Provider about the dosage appropriate for you.

If you miss a dose of Hyaluronic Acid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Hyaluronic Acid at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Hyaluronic Acid out of the reach of children and away from pets.

Do not take hyaluronic acid unless administered by a healthcare professional if:

You are pregnant or breast-feeding.

Hyaluronic Acid is not known to have any side effects if taken as per the prescribed dosage.

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