Ranimerck [in more detail]
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranimerck Mechanism Of Action:
The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.
Ranimerck Drug Interactions:
Anisindione The anti-H2 increases the anticoagulant effect Dicumarol The anti-H2 increases the anticoagulant effect Acenocoumarol The anti-H2 increases the anticoagulant effect Warfarin The anti-H2 increases the anticoagulant effect Itraconazole The anti-H2 decreases the absorption of the imidazole Ketoconazole The anti-H2 decreases the absorption of the imidazole Procainamide The histamine H2-receptor antagonist increases the effect of procainamide Dasatinib Possible decreased levels of dasatinib Atazanavir This gastric pH modifier decreases the levels/effects of atazanaivr Tolazoline Anticipated loss of efficacy of tolazoline
Avoid alcohol. Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication. Avoid excessive quantities of coffee or tea (Caffeine).
Ranimerck Chemical Formula: